CN115554335B - Protective essential oil and preparation method thereof - Google Patents
Protective essential oil and preparation method thereof Download PDFInfo
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- CN115554335B CN115554335B CN202210319000.2A CN202210319000A CN115554335B CN 115554335 B CN115554335 B CN 115554335B CN 202210319000 A CN202210319000 A CN 202210319000A CN 115554335 B CN115554335 B CN 115554335B
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- UWKAYLJWKGQEPM-LBPRGKRZSA-N Linaloyl acetate Natural products CC(C)=CCC[C@](C)(C=C)OC(C)=O UWKAYLJWKGQEPM-LBPRGKRZSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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Abstract
The invention discloses a protective essential oil for mother and infant, which comprises the following preparation raw materials in parts by weight: 30-50 parts of violet essential oil, 20-30 parts of tea tree essential oil, 10-30 parts of thyme essential oil and 10-30 parts of Uganli essential oil. The invention adopts the whole flowers of the agalloch eaglewood to extract the agalloch eaglewood to obtain the agalloch eaglewood thyme essential oil, improves the sterilization effect of the protective essential oil, ensures that the protective essential oil can resist invasion of viruses, bacteria and fungi after volatilizing in the environment, simultaneously has the effect of relieving cold and cough, and adopts (21-27) by adopting the synergistic effect of the Australia tea essential oil and the blue gel especially well essential oil: the weight ratio of (15-20) can alleviate the sterilization stimulation of the protective essential oil, so that the protective essential oil has a mild sterilization effect and is especially suitable for pregnant women and children.
Description
Technical Field
The invention relates to protective essential oil for a mother and an infant, relates to A61K, and particularly relates to the field of medical, dental or dressing preparations.
Background
With the development of society, more and more bacteria, viruses and other invisible harmful organisms are filled in our living environment, and the microbial infection symptoms such as cold, cough and the like are more and more common, especially for children and pregnant women with weak resistance and lack of exercise, the risk of being infected by the microbes in daily environments is extremely high. Once the medicine is infected by microorganisms such as bacteria and viruses, the medicine needs to be used for treatment, the medicine can reach the lesion part through the digestive circulatory system of the whole body, the medicine treatment has slow effect, the medicine is easy to remain in the body, and the medicine which is not metabolized can cause discomfort of the body in the body, so that the medicine has certain side effect.
Chinese patent No. 202010152776.0 discloses a compound essential oil for treating rhinitis and cold, which has the effects of isolating viruses and inhibiting the invasion of the viruses into human bodies by compounding eight kinds of essential oils of perfume with base oil, but the eight kinds of essential oils of perfume have strong taste irritation, and the fragrance is woody fragrance, so that the olfactory sensation and the irritation of the essential oils are not suitable for pregnant women and infants. Chinese patent No. 02812047.7 discloses a composition with antiviral activity for treating and preventing common cold, which can achieve the effects of killing bacteria and common cold virus by adopting various traditional Chinese medicine extracts, alcohol aromatic, water and surfactant for combination and compounding, but the composition needs to be used in a fixed time period by means of a gasification device, and cannot achieve the protection effect for a long time in a full period.
Disclosure of Invention
In order to improve the action mildness of the protective essential oil and improve the olfactory sensation of the essential oil, the first aspect of the invention provides the protective essential oil for the mother and the infant, which is prepared from the following raw materials in parts by weight: 30-50 parts of violet essential oil, 20-30 parts of tea tree essential oil, 10-30 parts of thyme essential oil and 10-30 parts of Uganli essential oil.
As a preferred embodiment, the preparation raw materials comprise, in parts by weight: 35-40 parts of violet essential oil, 21-27 parts of tea tree essential oil, 18-25 parts of thyme essential oil and 15-20 parts of Uganli essential oil.
As a preferred embodiment, the preparation raw materials comprise, in parts by weight: 38 parts of violet essential oil, 25 parts of tea tree essential oil, 21 parts of thyme essential oil and 17 parts of eucalyptus essential oil.
As a preferred embodiment, the thyme essential oil is selected from one or a combination of several of thyme essential oil of golden selvedge, thyme essential oil of broadleaf, thyme essential oil of small leaf, thyme essential oil of lemon, thyme essential oil of uk, thyme essential oil of creeping, thyme essential oil of peach flower, thyme essential oil of linalool.
As a preferred embodiment, the thyme essential oil is linalool thyme essential oil.
As a preferred embodiment, the linalool thyme essential oil is an essential oil prepared by a whole flower distillation extraction process.
The applicant finds that the sterilization and anti-inflammation effects of the protective essential oil can be improved by adopting the compound synergistic effect of the linalool thyme essential oil and other essential oils in the experimental process, and the protective essential oil has remarkable improvement effects on symptoms of cold and cough. The possible reasons for the guess are: the main component in the linaloe thyme essential oil is monoterpene alcohol linaloe and linaloe acetate, the linaloe thyme belongs to a multi-molecular structure, has multiple treatment effects, has good effects on sterilization and anti-inflammation, has good affinity with skin, is easy to volatilize and diffuse around the skin, can achieve a purification effect on surrounding air through the diffusion of the monoterpene alcohol linaloe alcohol and the linaloe acetate, and plays a role in preventing influenza. In addition, the good volatility of the monoterpene alcohol and the agilawood acetate can directly enter the lung through the nasal respiratory tract, so that the effect of quick sterilization is achieved, meanwhile, the essential oil is not easy to remain in the body due to the strong volatility, and the exhaled gas is discharged after the essential oil plays a role, so that the side effect of the protective essential oil on the body is reduced.
As a preferred embodiment, the violet essential oil is selected from one or a combination of several of idazo essential oil, karman violet essential oil, francisco violet essential oil, abbe violet essential oil, and incana violet essential oil.
As a preferred embodiment, the violet essential oil is an abbe violet essential oil.
As a preferred embodiment, the abbe violet essential oil is selected from one or a combination of several of violet flower extraction essential oil, violet leaf extraction essential oil and violet leaf extraction essential oil.
As a preferred embodiment, the abbe violet essential oil is an violet leaf extract essential oil.
The applicant finds that the storage stability and the effect stability of the protective essential oil can be improved by adopting the violet flowers and leaves to extract the essential oil in the experimental process, and the essential oils in each batch have smaller difference. The possible reasons for the guess are: the extract of the violet leaves contains alpha-ionone, has a certain anti-inflammatory and antioxidant effect, and can reduce the oxidative deterioration of other components in the essential oil and increase the storage stability of the protective essential oil by introducing the violet leaf essential oil. The violet leaf essential oil has weaker volatility, can play a certain weakening effect on volatilization of the essential oil in the use process, prevents the volatilization rate of the protective essential oil from being too fast, and avoids the difference of components, so that the protective essential oil has a stable use effect.
And the extraction efficiency of the violet leaf extraction essential oil is higher, and the production cost of the protection essential oil can be reduced when the violet leaf extraction essential oil is applied while the good use effect is kept.
As a preferred embodiment, the eucalyptus essential oil is one or a combination of several selected from Shi Taige eucalyptus essential oil, multi-bud eucalyptus essential oil, blue gum eucalyptus essential oil, peppermint eucalyptus essential oil, australian eucalyptus essential oil and lemon eucalyptus essential oil.
As a preferred embodiment, the essential oil of eugenia is a blue gum eugenia essential oil.
As a preferred embodiment, the blue gel eugenia essential oil is a steam distillation extraction process, and the refractive index of the blue gel eugenia essential oil is 1.458-1.47.
As a preferred embodiment, the tea tree essential oil is Australian tea tree essential oil, the refractive index of the Australian tea tree essential oil is 1.475-1.482, and the relative density at 25 ℃ is 0.885-0.906g/mL.
The applicant found in experiments that the use of tea tree essential oil in australia and euglene essential oil in blue was (21-27): the weight ratio of (15-20) is synergistic, so that the irritation of the protective essential oil can be alleviated on the basis of further improving the antibacterial effect of the protective essential oil, the protective essential oil has a mild sterilization effect, and the protective essential oil is especially suitable for pregnant women and infants. The possible reasons for the guess are: the 4-isopropyl toluene and eucalyptus She Shuchun contained in the Australian tea tree essential oil and the blue gum especially-welt essential oil have good three-bacterium killing effect, and can realize good protection and killing effects on bacteria, fungi and viruses at the same time, so that the sterilizing effect of the protection essential oil is further improved. And 4-isopropyl toluene in the Australian tea tree essential oil and the blue gel euganli essential oil has milder effect of eucalyptol than linalool and linaloyl acetate, the Australian tea tree essential oil and the blue gel euganli essential oil are prepared from (21-27): the introduction of the weight ratio of (15-20) can relieve the strong action and effect of the linalool thyme essential oil and can also keep good balance of sterilization effect.
The applicant finds that during the experimental process, the violet essential oil of the flower leaves, the tea tree essential oil of the Australia, the thyme essential oil of the linalool and the euglena essential oil of the blue gel adopt (35-40): (21-27): (18-25): the weight ratio of (15-20) can improve the olfactory effect of the protective essential oil, and the acceptance of the baby on the protective essential oil is obviously improved. The possible reasons for the guess are: the three kinds of essential oils, namely the Australian tea tree essential oil, the linalol thyme essential oil and the blue gum euganli essential oil, present woody Chinese herbal medicine fragrance, present astringent taste for babies and olfactory sensitive pregnant women, have more pungent smell and lower acceptance for the protection essential oil, but can blend the fragrance of the protection essential oil by introducing the violet essential oil of the flower leaves and adopting a proper weight ratio, so that the taste of the protection essential oil is converted into flower and fruit fragrance, and is easy to be accepted by the babies and the pregnant women.
The second aspect of the invention provides a preparation method of protective essential oil for mother and infant, which comprises the following steps:
(1) Sequentially adding violet essential oil, tea tree essential oil, thyme essential oil and eucalyptus essential oil according to parts by weight;
(2) Standing for 6-10h, bottling, and packaging.
The applicant finds that the protective essential oil can exert stable storage and protective effects by sequentially adding the violet essential oil, the tea tree essential oil, the thyme essential oil and the eucalyptus essential oil according to parts by weight and then adopting non-stirring standing. The possible reason is hypothesized that the essential oils slowly permeate, the essential oils have synergistic effect, and compared with the essential oils after stirring, air is introduced during stirring, so that oxidation reaction among essential oil components is accelerated, and the storage stability of the protective essential oil is reduced.
The third aspect of the invention provides a use method of protective essential oil for mother and infant, which comprises the following steps:
the protective essential oil is dripped on the felt cotton piece with the dripping amount of 2-3 drops, and the felt cotton piece is placed on a fixing device and worn with the user.
Compared with the prior art, the invention has the following beneficial effects:
(1) According to the protective essential oil for the mother and infant, the linalool thyme essential oil is obtained by extracting the whole flowers of the linalool thyme, so that the sterilization effect of the protective essential oil is improved, the protective essential oil can resist invasion of viruses, bacteria and fungi after volatilizing in the environment, and meanwhile, the protective essential oil has the effect of relieving cold and cough.
(2) The protective essential oil for the mother and infant adopts the synergistic effect of the Australian tea tree essential oil and the blue gum especially-welfare essential oil, wherein the Australian tea tree essential oil and the blue gum especially-welfare essential oil are as follows (21-27): the weight ratio of (15-20) can alleviate the sterilization stimulation of the protective essential oil, so that the protective essential oil has a mild sterilization effect and is especially suitable for pregnant women and children.
(3) According to the essential oil for the mother and infant, the essential oil prepared from the violet flower leaf extract has good storage stability and effect stability, and the effect difference among different batches of essential oils is reduced.
(4) The invention relates to a protective essential oil for mother and infant, which adopts (35-40) violet essential oil, australian tea tree essential oil, linalool thyme essential oil and blue gum especially welfare essential oil: (21-27): (18-25): the weight ratio of (15-20) improves the olfactory sensation of the protective essential oil, so that the protective essential oil presents an acceptable flower and fruit fragrance, and increases the acceptance degree of babies on the protective essential oil.
(5) The protective essential oil for the mother and infant provided by the invention directly enters the respiratory system through the nasal mucosa of a human body in an air volatilizing way, directly reaches the affected part, has a high effect taking speed, can be discharged out of the body through volatilizing, avoids residues in the body, and increases the metabolic burden of organs.
Detailed Description
The present invention will be specifically described below by way of examples. It is noted herein that the following examples are given solely for the purpose of further illustration and are not to be construed as limitations on the scope of the invention, as will be apparent to those skilled in the art in light of the foregoing disclosure.
In addition, the raw materials used are commercially available unless otherwise indicated.
Example 1
The essential oil for protecting the mother and the infant comprises the following raw materials in parts by weight: 38 parts of violet essential oil, 25 parts of tea tree essential oil, 21 parts of thyme essential oil and 17 parts of eucalyptus essential oil.
The thyme essential oil is linalool thyme essential oil and is prepared by a whole flower distillation and extraction process. Purchased from the chinese herbal medicine biological factory, jean Hua Tianbao.
The violet essential oil is Abbe violet essential oil, and is extracted from violet leaves. Purchased from the chinese herbal medicine biological factory, jean Hua Tianbao.
The Uganilli essential oil is blue gum Uganilli essential oil, and is a steam distillation extraction process, and the refractive index of the blue gum Uganilli essential oil is 1.458-1.47. Purchased from the chinese herbal medicine biological factory, jean Hua Tianbao.
The tea tree essential oil is Australian tea tree essential oil, the refractive index is 1.475-1.482, and the relative density at 25 ℃ is 0.878g/mL. Purchased from the chinese herbal medicine biological factory, jean Hua Tianbao.
A preparation method of protective essential oil for mother and infant comprises the following steps:
(1) Sequentially adding violet essential oil, tea tree essential oil, thyme essential oil and eucalyptus essential oil according to parts by weight;
(2) Standing for 8 hr, bottling, and packaging.
The application method of the protective essential oil for the mother and infant comprises the following steps of:
the protective essential oil is dripped on the felt cotton piece with the dripping amount of 3 drops, and the felt cotton piece is placed on a fixing device and worn with the user.
Example 2
The specific steps of the protective essential oil for mother and infant and the preparation and use method are the same as those of the embodiment 1, except that stirring is carried out in the step 2 of the preparation method, and then the protective essential oil is kept stand for 4 hours.
Example 3
The specific steps of the protective essential oil for mother and infant and the preparation and use method are the same as those of the embodiment 1, except that the preparation raw materials comprise the following components in parts by weight: 25 parts of green flower cajeput essential oil, 10 parts of atlantic cedar essential oil, 15 parts of thyme essential oil, 30 parts of tea tree essential oil and 21 parts of lavender essential oil. Purchased from the chinese herbal medicine biological factory, jean Hua Tianbao.
Example 4
The specific steps of the protective essential oil for mother and infant and the preparation and use method are the same as those of the embodiment 1, except that the preparation raw materials comprise the following components in parts by weight: 43 parts of biotone thyme essential oil, 15 parts of lavender essential oil, 29 parts of neroli essential oil and 14 parts of emulsifiable concentrate.
Example 5
The specific steps of the protective essential oil for mother and infant and the preparation and use method are the same as those of the embodiment 1, except that the preparation raw materials comprise the following components in parts by weight: 25 parts of violet essential oil, 25 parts of tea tree essential oil, 25 parts of thyme essential oil and 26 parts of eucalyptus essential oil.
Performance testing
1. Component analysis: the protective essential oil prepared in example 1 was subjected to GC-MS test, and the main components and contents were analyzed, and the test results are shown in table 1.
2. Antibacterial performance test: experimental strain: coli (8099), provided by the food safety engineering technology research and development center in Guangdong province, cultured for 3 rd generation; staphylococcus aureus (ATCC 6538), offered by the north na alliance biotechnology company, ltd, cultured for the third generation; candida albicans (ATCC 10231), offered by the north na alliance biotechnology company, ltd, cultures for the third generation; pseudomonas aeruginosa (ATCC 15442), offered by North Narah Biotechnology Co., ltd, was cultured for the third generation.
Culture medium: NA/20220107 (E.coli, staphylococcus aureus, pseudomonas aeruginosa), SDA/20220107 (Candida albicans).
The experimental basis is as follows: according to QB/T2738-2012, 7.3 of evaluation method of antibacterial and bacteriostatic effects of daily chemical products. Detection environment: temperature: 23.2 ℃, humidity: % RH (escherichia coli, staphylococcus aureus, candida albicans) temperature: 19.9 ℃, humidity: 58% RH (Pseudomonas aeruginosa)
Antibacterial effect: example 1 the essential oil protection was applied for 30min and the experiment was repeated 3 times.
The antibacterial effect of the escherichia coli is shown in table 2, the antibacterial effect of staphylococcus aureus is shown in table 3, the antibacterial effect of candida albicans is shown in table 4, and the antibacterial effect of pseudomonas aeruginosa is shown in table 5.
H1n1 influenza virus inactivation test: the influenza virus inactivating effect of the essential oil for protection of example 1 was tested in an environment with a temperature of 20.5 ℃ and a humidity of 45% rh by reference to "disinfection technical Specification" (2002 edition), the essential oil for protection of example 1 was absent from the control group, and the remaining parameters were identical, and the test results are shown in Table 6.
4. Stability test: the appearance of the essential oil was observed after the essential oil prepared in examples 1 to 3 was stored in an environment of 35 ℃ for 3 months. The test results are shown in Table 7.
5. Olfactory test: selecting 50 volunteers which are children with symptoms of cough, nasal discharge and thick phlegm and age 8-15, evaluating and testing the taste of the protective essential oil in the examples 1-3, wherein more than or equal to 40 volunteers consider that the taste is acceptable and is marked as excellent; 15-40 volunteers considered acceptable taste as good; less than or equal to 15 volunteers considered acceptable taste as poor. The test results are shown in Table 7. For the essential oils of examples 1-3
6. The using effect is as follows: 50 volunteers, 8-15 years old, were selected and children with cough, nasal discharge, and thick phlegm symptoms were tested for the relieving effect of the essential oil for protection of examples 1-3 on cough, nasal discharge, and thick phlegm symptoms. Symptom occurrence relief is marked to be excellent in 5-10 min; remission of symptoms occurring for 10-30min is marked as good; symptoms with or without relief over 30min were noted as poor.
TABLE 1
TABLE 2
TABLE 3 Table 3
TABLE 4 Table 4
TABLE 5
TABLE 6
TABLE 7
Claims (5)
1. The protective essential oil is characterized by comprising the following preparation raw materials in parts by weight: 35-40 parts of violet essential oil, 21-27 parts of tea tree essential oil, 18-25 parts of thyme essential oil and 15-20 parts of Uganli essential oil;
the thyme essential oil is linalool thyme essential oil and is prepared by a whole flower distillation and extraction process;
the violet essential oil is extracted from violet leaves;
the tea tree essential oil is Australian tea tree essential oil; the UGANLI essential oil is blue gum UGANLI essential oil.
2. The protective essential oil according to claim 1, wherein the violet essential oil is selected from one or a combination of several of ida violet essential oil, karman violet essential oil, francisco violet essential oil, abbe violet essential oil, and incana violet essential oil.
3. The protective essential oil according to claim 1, wherein the blue gel eugenia essential oil is prepared by a steam distillation extraction process, and the refractive index of the blue gel eugenia essential oil is 1.458-1.47.
4. The protective essential oil of claim 1, wherein the refractive index of the tea tree essential oil is 1.475-1.482 and the relative density at 25 ℃ is 0.878g/mL.
5. A process for the preparation of a protective essential oil according to any one of claims 1 to 4, characterized by the following steps:
(1) Sequentially adding violet essential oil, tea tree essential oil, thyme essential oil and eucalyptus essential oil according to parts by weight;
(2) Standing for 6-10h, bottling, and packaging.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998056395A1 (en) * | 1997-06-12 | 1998-12-17 | Antonio Sacchetti | Natural broad-spectrum antibiotic |
| CN109805038A (en) * | 2019-03-05 | 2019-05-28 | 天津中澳嘉喜诺生物科技有限公司 | A kind of Australia tea tree essential oil disinfection agent and its preparation method and application |
| CN111588748A (en) * | 2020-04-16 | 2020-08-28 | 云南绿新生物药业有限公司 | A thyme essential oil soft capsule for treating bronchitis and its treatment method |
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- 2022-03-29 CN CN202210319000.2A patent/CN115554335B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998056395A1 (en) * | 1997-06-12 | 1998-12-17 | Antonio Sacchetti | Natural broad-spectrum antibiotic |
| CN109805038A (en) * | 2019-03-05 | 2019-05-28 | 天津中澳嘉喜诺生物科技有限公司 | A kind of Australia tea tree essential oil disinfection agent and its preparation method and application |
| CN111588748A (en) * | 2020-04-16 | 2020-08-28 | 云南绿新生物药业有限公司 | A thyme essential oil soft capsule for treating bronchitis and its treatment method |
Non-Patent Citations (1)
| Title |
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| 金韵蓉.精油全书 珍藏版 30年芳疗经验集成.漓江出版社,2020,317-319. * |
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