KR102469315B1 - Hand sanitizer based on biocompatible MPC polymer and its manufacturing method - Google Patents

Abstract

The present invention relates to a hand sanitizer based on a biocompatible MPC polymer and a method for manufacturing the same, and more particularly, to a hand sanitizer containing purified water and methylacryloyloxyethyl phosphorylcholine (MPC), containing natural substances to have antibacterial and antiviral effects. It relates to a biocompatible MPC polymer-based hand sanitizer that can significantly improve and a manufacturing method thereof.

Description

Hand sanitizer based on biocompatible MPC polymer and its manufacturing method {Hand sanitizer based on biocompatible MPC polymer and its manufacturing method}

The present invention relates to a biocompatible MPC polymer-based hand sanitizer and a manufacturing method thereof, and more particularly to a biocompatible MPC polymer-based hand sanitizer containing a natural extract having antibacterial and antiviral effects and a manufacturing method thereof.

Bacteria or viruses that exist on human skin cause problems of various immune diseases in the human body. Usually, there are resident bacteria and transient bacteria, and about 90% of the resident bacteria cause food poisoning as Staphylococci.

In addition, in the case of viruses, they are infected through the nasal cavity through the hands, and cause various problems such as fever, vomiting, diarrhea and cough to people who are immune-deficient regardless of age or gender. Since these viruses survive for a long time on the skin surface and up to 4 hours on the hands, it can be said that virus infection is easy by contact.

Therefore, hand sanitizer is more important than anything else in order to prevent bacterial or viral diseases by preventing the spread of bacteria or viruses that reside on the hands. Currently, various personal hand sanitizers are sold to prevent the spread of infectious diseases around the world.

Hand sanitizers are generally prepared by containing 60% or more of alcohol, which causes a decrease in consumer preference due to a pungent scent. In addition, it is necessary to manufacture a hand sanitizer by adjusting the alcohol concentration to 60% or less because it is in violation of the Fire Protection Act of Korea. do. Therefore, various technologies have been proposed to solve this problem.

The proposed prior art is a hand sanitizer composition for antibacterial activity and alcohol deodorization containing a natural substance extract (Korean Patent Publication No. 10-2011-0030992). It includes an extract of any one selected natural substance, and the natural substance extract is obtained by adding each natural substance to alcohol 5 to 10 times the volume of the natural substance, leaving it for 20 to 28 hours, filtering, and concentrating under reduced pressure. provides antibacterial activity to

However, the prior art is different from the present invention in its specific configuration and manufacturing method, and compared to the detergents prepared in one embodiment and manufactured according to conventional hand sanitizers, the fragrance is still irritating and the antibacterial activity effect is not excellent. there is

Korean Patent Publication No. 10-2011-0030992: Antibacterial activity and alcohol deodorant hand sanitizer composition containing natural substance extracts

The present invention has been made to solve the above problems, and relates to a hand sanitizer based on a biocompatible MPC polymer that can significantly improve antibacterial and antiviral effects by containing natural substances and a method for manufacturing the same.

A hand sanitizer based on a biocompatible MPC polymer according to an embodiment of the present invention for achieving the above object includes purified water and methylacryloyloxyethyl phosphorylcholine (MPC).

The MPC is added by preparing an MPC aqueous solution in which MPC is mixed in a solvent, and then mixing the MPC aqueous solution with the purified water. Purified water is mixed, and the MPC aqueous solution further contains a natural antibacterial agent that prevents the growth of bacteria. manufactured by doing

The natural antibacterial agent is prepared by adding Nandina domestica Thunb to the cypress extract produced in the manufacturing process of the cypress extract oil, immersing and heating to extract the cypress extract.

On the other hand, the method for manufacturing a hand sanitizer based on a biocompatible MPC polymer according to an embodiment of the present invention is a cypress extract extraction step of extracting cypress extract water and cypress extract oil from a cypress tree, after the cypress extract extraction step, MPC aqueous solution MPC aqueous solution preparation step for producing, a mixed solution preparation step of preparing a mixed solution by mixing the MPC aqueous solution with purified water, an additive addition step of adding an additive to the prepared mixed solution, and filtering the mixed solution to which the additive is added. It includes a filtration step, and the step of extracting the cypress tree extract is heated by adding a solvent to the cypress tree, and cooling the water vapor generated by the heating to separate the cypress tree extract and the cypress tree extract oil, respectively.

The MPC aqueous solution preparation step is the step of preparing a cypress extract oil phase solution by dissolving a surfactant in the cypress extract oil extracted in the cypress tree extract extraction step to prepare a cypress extract oil phase solution, dissolving the MPC and a water-soluble crosslinking agent in purified water It includes an MPC solution preparation step of preparing an MPC solution and a mixing step of mixing the cypress extract oil phase solution and the MPC solution to prepare the MPC aqueous solution.

The MPC solution preparation step further includes a natural antimicrobial agent mixing step of mixing a natural antibacterial agent prepared by adding a mixed solvent to the cypress extract water extracted in the cypress tree extract extraction step and extracting the burdock extract by immersing and heating the burdock root.

In the step of mixing the natural antimicrobial agent, the Namcheon extract is extracted by adding Namcheon to the cypress extract in which the burdock is immersed, followed by immersion and heating.

Biocompatible MPC polymer-based hand sanitizer and method for manufacturing the same according to the present invention

It contains natural substances such as cypress tree extract, burdock extract and namcheon extract, which can significantly improve antibacterial and antiviral effects.

1 is a block diagram showing a method for manufacturing a hand sanitizer based on a biocompatible MPC polymer according to a preferred embodiment of the present invention.
Figure 2 is a block diagram showing the MPC solution manufacturing step of the biocompatible MPC polymer-based hand sanitizer manufacturing method according to a preferred embodiment of the present invention.
3 is a block diagram showing a natural antibacterial agent mixing step of a method for manufacturing a hand sanitizer based on a biocompatible MPC polymer according to a preferred embodiment of the present invention.

Hereinafter, a "hand sanitizer based on a biocompatible MPC polymer and a manufacturing method thereof" according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. Since the present invention can have various changes and various forms, specific embodiments will be illustrated in the drawings and described in detail in the text. However, this is not intended to limit the present invention to a specific form disclosed, and should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention. Like reference numerals have been used for like elements throughout the description of each figure. In the accompanying drawings, the dimensions of the structures are shown enlarged than actual for clarity of the present invention.

Terms such as first and second may be used to describe various components, but the components should not be limited by the terms. These terms are only used for the purpose of distinguishing one component from another. For example, a first element may be termed a second element, and similarly, a second element may be termed a first element, without departing from the scope of the present invention.

Terms used in this application are only used to describe specific embodiments, and are not intended to limit the present invention. Singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, terms such as "comprise" or "have" are intended to designate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, but one or more other features It should be understood that it does not preclude the possibility of the presence or addition of numbers, steps, operations, components, parts, or combinations thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which the present invention belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having a meaning consistent with the meaning in the context of the related art, and unless explicitly defined in the present application, they should not be interpreted in an ideal or excessively formal meaning. don't

The biocompatible MPC polymer-based hand sanitizer according to an embodiment of the present invention includes purified water and methylacryloyloxyethyl phosphorylcholine (Methacryloyl phosphoryl choline, MPC).

The purified water is a solvent that occupies most of the volume of the present invention, and it is preferable to use sterilized purified water effective for maintaining a sterilization or antibacterial state in the final product.

The MPC is methylacryloyloxyethyl phosphoryl choline, a substance in which a methacrylate group and a phosphorylcholine group are combined, and has the same structural formula as human cell membranes and is physically synthesized , which is a hydrophilic substance. As a moisturizer in the present invention, it provides lubricity to the skin surface.

The MPC is preferably mixed in an amount of 0.7 to 1.2 parts by weight based on 100 parts by weight of the purified water. When mixed with the above 0.7 or less, the skin moisturizing power may be lowered, and when mixed with the above 1.2 or more, there is a concern that the viscosity of the MPC aqueous solution described below may increase.

The MPC is added by preparing an aqueous solution in which MPC is mixed in a solvent, and then mixing and adding the MPC aqueous solution to the purified water. Purified water is mixed.

Therefore, spherical MPC hydrogel particles are dispersed and formed by the water-soluble crosslinking agent and MPC in the MPC aqueous solution, thereby increasing the feeling of moisture and improving lubricity, unlike the conventional technique of simply adding MPC.

The MPC aqueous solution further contains a natural antibacterial agent that prevents the growth of bacteria. The natural antibacterial agent is prepared by extracting the burdock extract by immersing and heating the burdock in the cypress extract water generated in the manufacturing process of the cypress extract oil.

The cypress extract can inhibit the growth of antibiotic-resistant strains, and the burdock extract is a natural substance that inhibits Staphylococcus aureus, a gram-positive bacterium as a bacterium, and maintains antibacterial activity even under acidic conditions of pH. As a compound, it is toxic and replaces antibacterial agents that could not guarantee the safety of the human body.

In addition, the natural antibacterial agent can be extracted by adding Nandina domestica Thunb to the cypress extract in which burdock is immersed, followed by immersion and heating.

The Namcheon is called Namcheon bamboo leaf, and has a therapeutic effect on whooping cough, hematuria, and bruises. In winter, the green leaves turn red, and in spring they turn blue again. The fruit of Namcheon is a round berry, about 050 to 100 cm, ripens in October and turns red. The fruit of Namcheon is called Namcheonsil, Namcheon, or Namcheonjukja in the private sector and is used as a medicine. It is known to be used in the treatment of chronic cough, syphilis, uterine bleeding, asthma, whooping cough, etc., and in one embodiment of the present invention, it has anti-allergic activity, so it can suppress allergic bacteria.

On the other hand, the biocompatible MPC polymer-based hand sanitizer manufacturing method includes cypress extract extraction step (S100), MPC aqueous solution manufacturing step (S200), mixed solution manufacturing step (S300), additive addition step (S400) and filtration step (S500). includes

In the cypress tree extract extraction step (S100), cypress tree and cypress oil are extracted, and a solvent is added to the cypress tree, heated, and the water vapor generated by the heating is cooled to separate into cypress tree extract and cypress tree extract oil, respectively do.

In the MPC aqueous solution preparation step (S200), an MPC aqueous solution is prepared after the cypress extract extraction step (S100), and the cypress extract oil phase solution preparation step (S210), MPC solution preparation step (S220), mixing step (S230), and A disinfectant addition step (S240) is included.

In the cypress extract oil phase solution preparation step (S210), a cypress extract oil phase solution is prepared by dissolving a surfactant in the cypress extract oil. The surfactant is Cetyl PEG/PPG-10/1 dimethicone (ABIL EM-90), sorbitan sesquioleate (ARLACEL 83), polyethylene glycol dipoly Hydroxy stearate (Polyethylene glycol dipolyhydroxy stearate (ARLACEL P135)) and the like can be used.

In the MPC solution preparation step (S220), an MPC solution is prepared by dissolving MPC and a water-soluble crosslinking agent in purified water. In the present invention, the MPC and the water-soluble crosslinking agent are preferably mixed in a weight ratio of 1:9.

The water-soluble crosslinking agent is preferably polypropylene glycol diacrylate (PPG-DA) or polyethylene glycol diacrylate (PEG-DA).

In addition, the MPC solution preparation step (S220) further includes a natural antimicrobial agent mixing step (S221). In the natural antimicrobial agent mixing step 221, a mixed solvent is added to the cypress extract water extracted in the cypress tree extract extraction step (S100), and burdock is immersed and heated to extract the burdock extract. Mixing the natural antibacterial agent with the MPC solution do.

The natural antimicrobial agent mixing step (S221) is a burdock washing and cutting step (S222), a burdock drying step (S223), a burdock roasting step (S224), a soaking step (S225), a base addition step (S226), a mixed solvent addition step ( S227), heating step (S228) and MPC solution mixing step (S229).

In the burdock washing and cutting step (S222), the leaves and stems of burdock are mixed in a weight ratio of 1:3, washed, and cut into sizes within the range of 0.1 mm to 20.0 mm. In the step of drying the burdock (S223), it is dried with hot air having a temperature in the range of 70 to 80 ° C.

In the burdock roasting step (S224), the dried burdock is steamed for 20 to 30 minutes in a vacuum state. In the immersion step (S225), the soaked burdock is immersed in the cypress extract water extracted in the cypress tree extraction step. At this time, it can be immersed by adding Namcheon to the cypress extract. The Namcheon can be immersed in several parts, but preferably any one selected from the leaves, stems and fruits of the Namcheon is immersed.

In the base addition step (S226), 0.1 to 10 parts by weight of a base is added based on 100 parts by weight of the cypress extract. The base may be sodium hydroxide (NaOH) or potassium hydroxide (KOH).

The base increases the extraction yield of flavonoids, which are antibacterial substances, from burdock. If it is less than the above range, the degree of increase in the extraction yield is insignificant, and if it exceeds the above range, antibacterial substances are hydrolyzed, which is not preferable.

In the mixed solvent addition step (S227), a mixed solvent is added to the cypress extract water in which burdock or burdock and Namcheon are immersed. The mixed solvent is purified water, carbon number, and C1 to C4 lower alcohol, polyhydric alcohol, or a mixture thereof.

In the heating step (S228), the cypress extract water in which the burdock or burdock root and namcheon are immersed in the mixed solvent addition step (S227) is heated, and heated to a temperature within the range of 100 to 150 ° C., so that a natural antibacterial agent is finally prepared.

In the MPC solution mixing step (S229), the natural antibacterial agent prepared by heating in the heating step (S228) is mixed with the MPC solution.

In the mixing step (S230), the cypress extract oil phase solution and the MPC solution are mixed to prepare an MPC aqueous solution. At this time, the cypress extract oil phase solution and the MPC solution are mixed in a weight ratio of 1:1 to 8:3. It is desirable to do

In the disinfectant adding step (S240), a disinfectant for sterilizing microorganisms, bacteria and organic matter is added to the MPC aqueous solution. The disinfectant is any one selected from silicon dioxide, titanium dioxide and nanosilver.

In the mixed solution preparation step (S300), a mixed solution is prepared by mixing the MPC aqueous solution with purified water, and a small amount of the MPC aqueous solution is added so that the MPC is 0.7 to 1.2 parts by weight based on 100 parts by weight of the purified water occupying the majority of the volume. Prepare a mixed solution.

In the additive adding step (S400), an additive is added to the mixed solution. The additive may be selected from among isotonic agents, excipients, stabilizers, buffers, solvents, viscosity control agents and pH control agents and added according to the user's needs. In the filtration step (S500), foreign substances present in the mixed solution are filtered, and finally, a hand sanitizer based on a biocompatible MPC polymer is prepared.

Example 1: Hand sanitizer based on biocompatible MPC polymer

Example 1 mixes methylacryloyloxyethyl phosphorylcholine (MPC) with purified water. At this time, the MPC is added by preparing an MPC aqueous solution in which MPC is mixed in a solvent, and then mixing the MPC aqueous solution with the purified water, but the MPC aqueous solution is a solution of cypress extract oil phase in which a surfactant is dissolved, MPC and a water-soluble crosslinking agent A hand sanitizer based on biocompatible MPC polymer mixed with dissolved purified water was prepared.

Example 2: Hand sanitizer based on biocompatible MPC polymer-2

In Example 2, the MPC aqueous solution of Example 1 further includes a natural antibacterial agent that prevents the growth of bacteria, and the natural antibacterial agent is immersed and heated in the cypress extract water produced in the process of preparing the cypress extract oil. Thus, a hand sanitizer based on a biocompatible MPC polymer with burdock extract and namcheon extract was manufactured.

Comparative Example 1: Hand Sanitizer-1

Comparative Example 1 prepared a hand sanitizer in which lotus leaf extract, purified water, alcohol and additives were mixed as a hand sanitizer of the prior art.

Comparative Example 2: Hand Sanitizer-2

Comparative Example 2 prepared a hand sanitizer in which ethanol, citrus extract, plum extract, tangerine extract, and additives were mixed as a conventional hand sanitizer.

Comparative Example 3: Hand Sanitizer-3

Comparative Example 3 prepared a hand sanitizer mixed with cinnamon, cloves, barberry, ethanol and additives as a prior art hand sanitizer.

Test Example 1: Antimicrobial activity

Antimicrobial activity tests of Examples 1 and 2 and Comparative Examples 1 to 3 were conducted. Organisms were inoculated into the samples of each Example and Comparative Example to test the antimicrobial activity over a period of time. The test results are shown in Tables 1 to 5 below.

Organisms Used: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida Albicans, Aspergillus niger Gilus Niger)

Example 1 organisms (microorganisms) Viability (cfu/ml) 1 day 7 days 14 days 28 days Escherichia coli 0 0 0 0 Staphylococcus aureus 0 0 0 0 Pseudomonas aeruginosa 0.2 x 10 ² 0 0 0 Candida Albicans 0.2 x 10 ² 0 0 0 Aspergillus niger 0.2 x 10 ² 0.2 x 10 ² 0 0

Example 2 organisms (microorganisms) Viability (cfu/ml) 1 day 7 days 14 days 28 days Escherichia coli 0 0 0 0 Staphylococcus aureus 0 0 0 0 Pseudomonas aeruginosa 0 0 0 0 Candida Albicans 0 0 0 0 Aspergillus niger 0.1 x 10 ² 0.2 x 10 ² 0 0

Comparative Example 1 organisms (microorganisms) Viability (cfu/ml) 1 day 7 days 14 days 28 days Escherichia coli 0 0 0 0 Staphylococcus aureus 0.5 x 10 ² 0 0 0 Pseudomonas aeruginosa 0.8 x 10 ² 0 0 0 Candida Albicans 0.4 x 10 ² 0.8 x 10 ² 0 0 Aspergillus niger 0.2 x 10 ² 0.2 x 10 ² 0 0

Comparative Example 2 organisms (microorganisms) Viability (cfu/ml) 1 day 7 days 14 days 28 days Escherichia coli 0 0 0 0 Staphylococcus aureus 0.2 x 10 ² 0 0 0 Pseudomonas aeruginosa 0.4 x 10 ² 0.2 x 10 ² 0 0 Candida Albicans 0.4 x 10 ² 0.1 x 10 ² 0 0 Aspergillus niger 0.6 x 10 ² 0.2 x 10 ² 0 0

Comparative Example 3 organisms (microorganisms) Viability (cfu/ml) 1 day 7 days 14 days 28 days Escherichia coli 0 0 0 0 Staphylococcus aureus 0.4 x 10 ² 0 0 0 Pseudomonas aeruginosa 0.4 x 10 ² 0.8 x 10 ² 0 0 Candida Albicans 0.2 x 10 ² 0.7 x 10 ² 0 0 Aspergillus niger 0.2 x 10 ² 0.2 x 10 ² 0 0

As shown in Tables 1 to 5, it can be confirmed that Examples 1 and 2 exhibited better antimicrobial activity than Comparative Examples 1 to 3. These results can be said to prove that the natural substances of one embodiment of the present invention are excellent in antimicrobial activity while securing safety.

Test Example 2: Storage stability test

Examples 1 and 2 and Comparative Examples 1 to 3 were placed in a bottle made of HDPE, sealed, and then stored in a thermo-hygrostat at a temperature of 40° C. and a relative humidity of 75%, while the degree of impurity generation was compared for 8 weeks. At this time, the content of impurities was measured by adding each disinfectant to a mixture of methanol 0.0375 mol/L 1-decanesulfonate sodium solution and perchloric acid (600:400:1), thoroughly dissolving through ultrasonic treatment, and filtering with a 0.45㎛ membrane filter to obtain a liquid chromatograph. Measured according to the law. The content of the impurities is shown in Table 6.

storage institution immediately after manufacturing 2 weeks 4 weeks 8 weeks Example 1 0.05 0.09 0.06 0.12 Example 2 ND ND 0.08 0.15 Comparative Example 1 0.12 0.14 0.20 0.31 Comparative Example 2 0.14 0.19 0.26 0.40 Comparative Example 3 0.21 0.26 0.36 0.45

In the case of the samples prepared in Examples 1 and 2, the impurity content after aging for 8 weeks was 0.16% by weight or less. Therefore, it was confirmed that the storage stability was improved as a disinfectant. However, in the case of Comparative Examples 1 to 3, the content of impurities after 8 weeks of aging showed lower storage stability than that of Examples.

In particular, in Example 2, the burdock extract and the Namcheon extract were included by immersing and heating the burdock and Namcheon in the cypress extract produced during the manufacturing process of the Cypress extract oil, and showed a better effect in the storage stability test. In particular, it can be seen that there is an advantage in maintaining stability according to pH and chemical changes by the chlorogenic acid contained in the burdock extract.

Test Example 3: Evaluation of user satisfaction

Twenty healthy adults evaluated each sample of Examples 1 and 2 and Comparative Examples 1 to 3 on a scale of 1 (poor) to 5 (excellent) for the feeling of use and the feeling after use when touched and rubbed by hand. The average value was calculated and the results are shown in Table 7 below.

ingredient Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Satisfaction with the feeling of use 5 5 3 2 2 Formulation state 4 5 2 3 2

It was found that Examples 1 and 2 had a better effect than the most conventional comparative example in terms of satisfaction with use and formulation state. It is believed that this is due to the inclusion of methylethylacryloyloxyethyl phosphorylcholine, which has a moisturizing effect as well as a role of lubrication.

Test Example 4: Sensory evaluation

In order to evaluate the alcohol deodorizing effect, the sensory properties of Examples 1 and 2 and Comparative Examples 1 to 3 containing alcohol were evaluated. For this evaluation, 100 evaluation groups without any health problems were randomly selected, the purpose of this experiment was explained, and the sensory test was conducted after familiarizing themselves with the experiment method.

The evaluation score was set to 5 when the unpleasant odor was reduced the most (when the deodorizing effect was excellent) (when there was no alcohol smell) and 1 when the deodorizing effect was the least satisfactory, and the evaluation results are shown in Table 8 below.

division Evaluation results Example 1 4.88 Example 2 4.79 Comparative Example 1 4.15 Comparative Example 2 4.23 Comparative Example 3 4.33

Evaluation Results Examples 1 and 2 had better evaluation results than Comparative Examples, and through this, it can be seen that the pungent flavor of ethanol was significantly reduced by the cypress tree extract, burdock extract and Namcheon extract.

The description of the presented embodiments is provided to enable any person skilled in the art to use or practice the present invention. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be applied to other embodiments without departing from the scope of the present invention. Thus, the present invention is not to be limited to the embodiments presented herein, but is to be interpreted in the widest scope consistent with the principles and novel features presented herein.

S100: Cypress extract extraction step
S200: MPC aqueous solution manufacturing step
S210: Cypress extract oil phase solution preparation step
S220: MPC solution manufacturing step
S221: Natural antibacterial agent mixing step
S222: Burdock washing and cutting step
S223: Burdock drying step
S224: Burdock roasting step
S225: immersion step
S226: base addition step
S227: mixed solvent addition step
S228: heating step
S229: MPC solution mixing step
S230: mixing step
S240: disinfectant addition step
S300: Mixed solution manufacturing step
S400: additive addition step

Claims (7)

Contains purified water and methylacryloyloxyethyl phosphorylcholine (MPC),
The MPC is added by preparing an MPC aqueous solution in which MPC is mixed in a solvent, and then mixing the MPC aqueous solution with the purified water,
The MPC aqueous solution is a mixture of a solution of cypress extract oil in which a surfactant is dissolved and purified water in which MPC and a water-soluble crosslinking agent are dissolved,
The MPC aqueous solution further includes a natural antibacterial agent that prevents the growth of bacteria,
The natural antibacterial agent is characterized in that it is prepared by extracting the burdock extract by immersing and heating the burdock in the cypress extract produced in the manufacturing process of the cypress extract oil.
Hand sanitizer composition based on biocompatible MPC polymer.
delete According to claim 1,
The natural antibacterial agent is characterized in that it is prepared by adding Nandina domestica Thunb to the cypress extract produced in the manufacturing process of the cypress extract oil, immersing and heating to extract the cypress extract.
Hand sanitizer composition based on biocompatible MPC polymer.
A cypress tree extract extraction step of extracting cypress extract water and cypress extract oil from cypress trees;
After the cypress tree extract extraction step, MPC aqueous solution preparation step of preparing an MPC aqueous solution;
Mixed solution preparation step of preparing a mixed solution by mixing purified water with the MPC aqueous solution;
An additive adding step of adding an additive to the prepared mixed solution; and
And a filtration step of filtering the mixed solution to which the additive is added,
The cypress tree extract extraction step is characterized in that a solvent is added to the cypress tree, heated, and the water vapor generated by the heating is cooled to separate the cypress extract water and the cypress extract oil, respectively.
Method for manufacturing a hand sanitizer composition based on biocompatible MPC polymer.
According to claim 4,
The step of preparing the MPC aqueous solution
A cypress extract oil phase solution preparation step of preparing a cypress extract oil phase solution by dissolving a surfactant in the cypress extract oil extracted in the cypress extract extraction step;
An MPC solution preparation step of preparing an MPC solution by dissolving MPC and a water-soluble crosslinking agent in purified water; and
Characterized in that it comprises a mixing step of mixing the cypress extract oil phase solution and the MPC solution to prepare the MPC aqueous solution
Method for manufacturing a hand sanitizer composition based on biocompatible MPC polymer.
According to claim 5,
The MPC solution preparation step further comprises a natural antimicrobial agent mixing step of mixing a natural antibacterial agent prepared by adding a mixed solvent to the cypress extract water extracted in the cypress tree extract extraction step and extracting the burdock extract by immersing and heating the burdock. characterized
Method for manufacturing a hand sanitizer composition based on biocompatible MPC polymer.
According to claim 6,
In the natural antimicrobial agent mixing step, the burdock is added to the cypress extract in which the burdock is immersed, characterized in that the extract is extracted by immersion and heating.
Method for manufacturing a hand sanitizer composition based on biocompatible MPC polymer.

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