CN115380031A - 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用 - Google Patents
作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用 Download PDFInfo
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- CN115380031A CN115380031A CN202180025093.1A CN202180025093A CN115380031A CN 115380031 A CN115380031 A CN 115380031A CN 202180025093 A CN202180025093 A CN 202180025093A CN 115380031 A CN115380031 A CN 115380031A
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- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract
提供了一种作为ATM抑制剂的喹啉并吡咯烷‑2‑酮类化合物(I)的晶型及其制备方法，及其在制备治疗与实体瘤相关疾病的药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (21)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2020102379234 | 2020-03-30 | ||
| CN202010237923 | 2020-03-30 | ||
| PCT/CN2021/084062 WO2021197339A1 (zh) | 2020-03-30 | 2021-03-30 | 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN115380031A true CN115380031A (zh) | 2022-11-22 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| CN202180025093.1A Pending CN115380031A (zh) | 2020-03-30 | 2021-03-30 | 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN115380031A (zh) |
| WO (1) | WO2021197339A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102399218A (zh) * | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
| WO2017194632A1 (en) * | 2016-05-11 | 2017-11-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| CN107889488A (zh) * | 2015-04-02 | 2018-04-06 | 默克专利股份公司 | 咪唑酮基喹啉和其作为atm激酶抑制剂的用途 |
| CN108349971A (zh) * | 2015-11-03 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
| CN108348515A (zh) * | 2015-11-05 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
| CN110386932A (zh) * | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
| CN112771045A (zh) * | 2018-09-30 | 2021-05-07 | 南京明德新药研发有限公司 | 喹啉并吡咯烷-2-酮类衍生物及其应用 |
-
2021
- 2021-03-30 CN CN202180025093.1A patent/CN115380031A/zh active Pending
- 2021-03-30 WO PCT/CN2021/084062 patent/WO2021197339A1/zh active Application Filing
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102399218A (zh) * | 2010-09-16 | 2012-04-04 | 和记黄埔医药（上海）有限公司 | 一类并合三杂环及其作为pi3k抑制剂的用途 |
| CN107889488A (zh) * | 2015-04-02 | 2018-04-06 | 默克专利股份公司 | 咪唑酮基喹啉和其作为atm激酶抑制剂的用途 |
| CN108349971A (zh) * | 2015-11-03 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
| CN108348515A (zh) * | 2015-11-05 | 2018-07-31 | 阿斯利康(瑞典)有限公司 | 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途 |
| WO2017194632A1 (en) * | 2016-05-11 | 2017-11-16 | Astrazeneca Ab | Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer |
| CN110386932A (zh) * | 2018-04-20 | 2019-10-29 | 艾科思莱德制药公司 | 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂 |
| CN112771045A (zh) * | 2018-09-30 | 2021-05-07 | 南京明德新药研发有限公司 | 喹啉并吡咯烷-2-酮类衍生物及其应用 |
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| WO2021197339A1 (zh) | 2021-10-07 |
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