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CN112771045A - 喹啉并吡咯烷-2-酮类衍生物及其应用 - Google Patents

喹啉并吡咯烷-2-酮类衍生物及其应用 Download PDF

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CN112771045A
CN112771045A CN201980064561.9A CN201980064561A CN112771045A CN 112771045 A CN112771045 A CN 112771045A CN 201980064561 A CN201980064561 A CN 201980064561A CN 112771045 A CN112771045 A CN 112771045A
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CN112771045B (zh
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钱文远
杨纯道
代国强
黎健
陈曙辉
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Medshine Discovery Inc
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    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20—Spiro-condensed systems

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

公开了一系列喹啉并吡咯烷‑2‑酮类的化合物，及其在制备ATM抑制剂相关疾病的药物中的应用。具体涉及了式(Ι)所示衍生化合物、其互变异构体或其药学上可接受的组合物。
Figure DDA0003000032560000011

Description

PCT国内申请，说明书已公开。

Claims (24)

  1. PCT国内申请，权利要求书已公开。
CN201980064561.9A 2018-09-30 2019-09-27 喹啉并吡咯烷-2-酮类衍生物及其应用 Active CN112771045B (zh)

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CN201811157825 2018-09-30
CN2018111578259 2018-09-30
PCT/CN2019/108520 WO2020063855A1 (zh) 2018-09-30 2019-09-27 喹啉并吡咯烷-2-酮类衍生物及其应用

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JP (1) JP6997358B2 (zh)
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AU (1) AU2019348132B2 (zh)
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RU (1) RU2771314C1 (zh)
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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112469720A (zh) * 2018-04-20 2021-03-09 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
CN115380031A (zh) * 2020-03-30 2022-11-22 南京明德新药研发有限公司 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用
CN117355528A (zh) * 2021-05-08 2024-01-05 成都嘉葆药银医药科技有限公司 吡咯并三嗪类化合物的盐型、其晶型及其制备方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021098734A1 (zh) * 2019-11-19 2021-05-27 南京明德新药研发有限公司 作为atm抑制剂的有取代的喹啉吡咯酮类合物及其应用

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WO2009155527A2 (en) * 2008-06-19 2009-12-23 Progenics Pharmaceuticals, Inc. Phosphatidylinositol 3 kinase inhibitors
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
WO2017194632A1 (en) * 2016-05-11 2017-11-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
CN107889488A (zh) * 2015-04-02 2018-04-06 默克专利股份公司 咪唑酮基喹啉和其作为atm激酶抑制剂的用途
CN108349971A (zh) * 2015-11-03 2018-07-31 阿斯利康(瑞典)有限公司 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途
CN108348515A (zh) * 2015-11-05 2018-07-31 阿斯利康(瑞典)有限公司 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途

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MX2008013428A (es) 2006-04-18 2008-11-04 Abbott Lab Antagonistas del receptor de vanilloides del subtipo (vr1) y usos de los mismos.
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009155527A2 (en) * 2008-06-19 2009-12-23 Progenics Pharmaceuticals, Inc. Phosphatidylinositol 3 kinase inhibitors
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
CN107889488A (zh) * 2015-04-02 2018-04-06 默克专利股份公司 咪唑酮基喹啉和其作为atm激酶抑制剂的用途
CN108349971A (zh) * 2015-11-03 2018-07-31 阿斯利康(瑞典)有限公司 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途
CN108348515A (zh) * 2015-11-05 2018-07-31 阿斯利康(瑞典)有限公司 咪唑并[4,5-c]喹啉-2-酮化合物以及它们在治疗癌症中的用途
WO2017194632A1 (en) * 2016-05-11 2017-11-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112469720A (zh) * 2018-04-20 2021-03-09 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
CN112469720B (zh) * 2018-04-20 2024-03-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
CN115380031A (zh) * 2020-03-30 2022-11-22 南京明德新药研发有限公司 作为atm抑制剂的喹啉并吡咯烷-2-酮类化合物的晶型及其应用
CN117355528A (zh) * 2021-05-08 2024-01-05 成都嘉葆药银医药科技有限公司 吡咯并三嗪类化合物的盐型、其晶型及其制备方法

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US11230549B2 (en) 2022-01-25
US20210380599A1 (en) 2021-12-09
JP6997358B2 (ja) 2022-01-17
AU2019348132A1 (en) 2021-05-20
CN112771045B (zh) 2022-04-19
JP2021529214A (ja) 2021-10-28
CA3114646A1 (en) 2020-04-02
BR112021005989A2 (pt) 2021-06-29
AU2019348132B2 (en) 2022-03-31
WO2020063855A1 (zh) 2020-04-02
CA3114646C (en) 2022-03-08
KR20210060613A (ko) 2021-05-26
EP3845532A1 (en) 2021-07-07
MX391410B (es) 2025-03-21
KR102345208B1 (ko) 2021-12-30
EP3845532B1 (en) 2022-12-21
EP3845532A4 (en) 2021-11-17
MX2021003739A (es) 2022-04-07

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