CN115282370A - Dialysate preparation system, dialysate preparation and degassing method thereof - Google Patents

Abstract

The invention relates to the technical field of hemodialysis treatment, in particular to a dialysate preparation system, a dialysate preparation and a degassing method thereof. The first concentrated liquid input line, the second concentrated liquid input line and the reverse osmosis water input line, by mixing the first concentrated liquid, the second concentrated liquid and the reverse osmosis water in the second mixing tank, so that the first concentrated liquid , The air bubbles in the second concentrated solution are separated out in the second mixing tank, and then the gas in the second mixing tank is eliminated by the degassing device arranged on the second mixing tank, and the dialysate preparation system, The dialysate preparation and its degassing method can greatly simplify the equipment composition of the dialysate preparation system, but it can still remove a small amount of gas that may exist in the A concentrate and the B concentrate to ensure the safety and efficiency of dialysis treatment.

Description

Dialysate preparation system, dialysate preparation and degassing method thereof

technical field

The invention relates to the technical field of hemodialysis treatment, in particular to a dialysate preparation system, dialysate preparation and a degassing method thereof.

Background technique

The process of hemodialysis treatment is to drain the blood from the patient's body to the outside of the body, and pass through a dialyzer composed of many hollow fiber membranes. The blood and the dialysate generated by the dialysis machine exchange materials through diffusion/convection inside and outside the hollow fiber membranes. , remove metabolic waste in the patient's blood, maintain electrolyte and acid-base balance, remove excess water in the body at the same time, and then return the purified blood to the human body. The dialysate of the commonly used dialysis machine is composed of A concentrated solution, B concentrated solution and reverse osmosis water according to a certain proportion of online continuous configuration, A concentrated solution generally contains sodium chloride, potassium chloride, calcium chloride, magnesium chloride, ice Acetic or citric acid, sodium acetate, B concentrate generally contains sodium bicarbonate or sodium bicarbonate and sodium chloride. During the dialysis treatment, it is necessary to ensure that the concentration of various components of the dialysate is continuously stable, otherwise the dialysate will change the concentration of chemical components in the blood through diffusion in the dialyzer, endangering the safety of the patient. Therefore, only by ensuring a constant output flow rate of concentrated liquid A, concentrated liquid B, and the dialysate controlled by the balance system, can the concentration of each component in the continuously configured dialysate be stable, and it is also required that concentrated liquid A, concentrated liquid B, and reverse osmosis water There should be no air to avoid fluctuations in dialysate concentration caused by air and possible air embolism caused by air in the dialysate.

Due to the above reasons, the current hemodialysis machines generally have a negative pressure degassing system, which can remove the gas in the reverse osmosis water through negative pressure, but almost no dialysis equipment is specially equipped with a device for degassing the A concentrate and the B concentrate . During the actual treatment process, the dissolved gas in the concentrated solution A and the concentrated solution B will also produce a small amount of air bubbles due to temperature changes, resulting in a small amount of air bubbles in the dialysate, which reduces the safety of dialysis treatment. Therefore, in order to ensure the safety of dialysis treatment, the currently commonly used dialysate preparation system is generally shown in Figure 1. The system is provided with a first conductivity sensor and a second conductivity sensor. The process of preparing dialysate by using the dialysate preparation system Generally as follows: Firstly, the B concentrate pump sucks the B concentrate and reverse osmosis water, and then enters the first mixing tank for mixing to form the first mixed liquid, and then passes the first mixed liquid through the first-stage conductivity sensor and transports it to the second mixing tank , and then the A concentrate pump sucks the A concentrate into the second mixing tank, and realizes the remixing of the first mix and the A concentrate in the second mixing tank, thereby forming a dialysate, which is again After being detected by the second conductivity sensor, it is sent to the balance system, and finally sent to the dialyzer for use. During this process, when the bubbles of concentrated liquid A or concentrated liquid B pass through the first conductivity sensor and the second conductivity sensor, the conductance value of the first conductivity sensor and the second conductivity sensor will decrease, thereby triggering a system alarm. The safety of the treatment, at this time, the hemodialysis equipment during the treatment will generally enter the bypass state and suspend the treatment. Real-time monitoring of the air bubbles can effectively ensure the safety of dialysis treatment. However, the dialysate preparation system cannot directly deal with the air bubbles in the dialysate, and the first conductivity sensor and the second conductivity sensor will frequently An alarm occurs and causes the suspension of the treatment process, which greatly reduces the treatment efficiency.

In order to solve the defects in the above-mentioned dialysate preparation system, some dialysis machines are designed with separate A concentrated liquid degassing device and B concentrated liquid degassing device before the A concentrated liquid pump and B concentrated liquid pump, and through the A concentrated liquid degassing device and B concentrated liquid degassing device to remove the gas in the A concentrated liquid and the B concentrated liquid respectively, so as to ensure the complete removal of the gas in the A concentrated liquid and the B concentrated liquid. The possibility of mixing air bubbles in the dialysate prepared online is greatly reduced, and the safety of treatment is further improved. But for this kind of dialysate preparation system, since it is provided with A concentrated liquid degassing device and B concentrated liquid degassing device separately, therefore, it is necessary to add multiple degassing devices and control valve bodies, resulting in the overall control method is complicated, in the treatment It takes a long time to rinse the whole dosing system clean during the pre-flushing stage before treatment and the cleaning and disinfection process after treatment, which will waste a lot of time and water resources, and greatly increase the economic cost and time cost of treatment.

Contents of the invention

In order to solve the above technical problems, the object of the present invention is to provide a dialysate preparation system, dialysate preparation and degassing method thereof, the dialysate preparation system, dialysate preparation and its degassing method can realize the automatic preparation of dialysate Automatic degassing during the process, while ensuring the quality of the dialysate and the safety of the dialysis treatment.

In order to achieve the above technical effects, the present invention adopts the following technical solutions:

In a first aspect, a dialysate preparation system provided by the present invention includes:

The first concentrated liquid input pipeline is used for inputting the first concentrated liquid;

The second concentrated solution input pipeline is used for inputting the second concentrated solution;

The reverse osmosis water input pipeline is used for inputting reverse osmosis water;

The second mixing tank, the second mixing tank is used to mix the first concentrated liquid, the second concentrated liquid and the reverse osmosis water to form a dialysate, and the second mixed tank outputs the dialysate through the dialysate output line, And the dialysate output pipeline is also provided with a second conductivity sensor;

A degassing device connected to the top of the second mixing tank and used to remove the gas in the second mixing tank.

Preferably, at least one reverse osmosis water degassing device is provided in the reverse osmosis water input pipeline to remove a large number of air bubbles existing in the reverse osmosis water, and the reverse osmosis water degassing device can be selected from the prior art.

Further, the dialysate preparation system also includes:

The first mixing tank, the first mixing tank is arranged downstream of the first concentrated liquid input line and the reverse osmosis water input line, and the first mixing tank is used to premix the first concentrated liquid and reverse osmosis water, so as to A premix is formed, and the first mixing tank delivers the premix to the second mixing tank through a premix passage.

Further, the purpose of the first mixing tank and the second mixing tank is to mix the liquids input into them, and their internal structures can be selected and designed according to needs.

Further, the top of the first mixing tank is provided with an upper outlet, and the bottom of the first mixing tank is provided with a lower outlet, and the premixed liquid passage includes a first passage and a second passage, and the first passage is used for The upper outlet is communicated with the second mixing tank, the second passage is used to communicate with the lower outlet and the second mixing tank, and the second passage is provided with a first conductance sensor, and the first conductance sensor uses For the preliminary measurement of the conductivity of the premixed liquid, the first path can pass through the liquid at the top of the first mixing tank and the air bubbles that may collect at the top of the first mixing tank. At the same time, since there is no conductivity in the first path The sensor can avoid false alarms of the dialysate preparation system.

Further, the first concentrated solution is B concentrated solution, the second concentrated solution is A concentrated solution, and the A concentrated solution and B concentrated solution can be prepared according to existing preparation standards, and have relatively stable electrical conductivity .

Further, the bottom of the second mixing tank is provided with a dialysate outlet, and the liquid inlet end of the dialysate output line is connected to the dialysate outlet, so as to prevent air bubbles in the second mixing tank from entering the dialysate output line In addition, a gas outlet is provided on the top of the second mixing tank, and one end of the degassing device is connected to the gas outlet, so as to discharge the air bubbles in the second mixing tank to the outside.

Preferably, the top of the second mixing tank is provided with a gas collection part, and the top of the gas collection part is provided with a gas outlet, and the cross-sectional area of the gas collection part gradually shrinks from bottom to top, thus, due to the The arrangement of the gas collection part makes it easy for the gas in the second mixing tank to collect to the top of the second mixing tank, so that the gas in the second mixing tank is easy to be completely discharged outside through the degassing device.

Preferably, the outlet end of the dialysate output line is connected to the balance system of the dialysis treatment equipment, and the dialysate prepared by the dialysate preparation system can be transported to the dialysis treatment equipment for use through the balance system. The balance system, The structure and connection mode of the dialysis treatment equipment belong to the prior art, so details are not described here.

Further, the degassing device includes a negative pressure exhaust pipeline, and a degassing solenoid valve and a negative pressure degassing pump are arranged on the negative pressure exhaust pipeline.

Further, a liquid level sensor is provided inside the second mixing tank, and the liquid level sensor is used to monitor the liquid level in the second mixing tank in real time, so as to obtain the real-time liquid level height in the second mixing tank .

Further, the dialysate preparation system also includes a control unit, a first output pump and a second output pump are respectively arranged on the first concentrate input line and the second concentrate input line, and the first output pump, The second output pump, the second conductivity sensor and the degassing device are all electrically or signally connected to the control unit, so as to realize the automatic preparation of dialysate.

In a second aspect, the present invention also provides a dialysate degassing method, the degassing method comprising:

S21: detection step, detecting and obtaining the real-time liquid level in the second mixing tank;

S22: Judging step, judging whether the real-time liquid level height is lower than the preset liquid level height;

S23: Execution step, when the judgment step is judged to be yes, start the degassing device to perform an exhaust operation to remove the gas in the second mixing tank.

Further, in the supply process, the first concentrated liquid is mixed with the reverse osmosis water prior to the second concentrated liquid to form a premixed liquid, and the second concentrated liquid is mixed with the premixed liquid and delivered to The second mixing tank or the second concentrated liquid and the premixed liquid are separately delivered to the second mixing tank.

Further, the S23 is specifically: when the judging step is judged to be yes, start the degassing device to perform an exhaust operation to at least partially remove the gas in the second mixing tank or completely remove the gas in the second mixing tank. Exhaust outward.

Preferably, when the real-time liquid level in the second mixing tank is lower than the preset liquid level, the degassing device is activated to remove the gas in the second mixing tank, and when the liquid level in the second mixing tank Stop the exhaust operation when returning to H1, said H1 is greater than the preset liquid level height, and said H1 is less than or equal to the maximum liquid level height in the second mixing tank.

Further, the exhaust operation is intermittent exhaust.

Further, the exhaust operation is intermittent exhaust, and the single maximum exhaust volume is Vmax, and the Vmax is less than or equal to the maximum volume of reverse osmosis water added to the dialysate preparation system in a single time, and the single The maximum volume of supplementary reverse osmosis water refers to the maximum volume of supplementary reverse osmosis water that is allowed to supplement a certain volume of reverse osmosis water in the dialysate preparation system without causing the detection value of the second conductivity sensor to exceed the set threshold range. Preferably, the Vmax is equal to The maximum volume of reverse osmosis water added to the dialysate preparation system for a single time. During this process, since the volumes of the tanks and pipelines that make up the dialysate preparation system are constant, the volume of gas discharged from the second mixing tank is supplemented by adding reaction to the dialysate preparation system. Seep water is supplemented so that the concentration and conductivity of the prepared dialysate meet the requirements. Therefore, in the present invention, by controlling the single maximum exhaust volume, the reverse fluid that enters the dialysate preparation system during each exhaust is The seepage water volume is controllable, which avoids the system alarm caused by the excessive fluctuation of the dialysate concentration caused by the excessive volume of reverse osmosis water replenishment in a single time, and can ensure the safety of the treatment process.

Specifically, the set threshold range of the detection value of the second conductivity sensor is ±0.1-5% of the conductivity of the standard dialysate, and the standard dialysate can be prepared according to relevant standards to obtain the standard dialysate conductivity.

Further, the present invention also provides a specific calculation method for a single maximum exhaust volume, specifically, the single maximum exhaust volume is Vmax, and the Vmax is calculated in the following manner:

Vmax=Vtotal*x%

Wherein, the V total is the total volume between the mixing point of the first concentrated solution and reverse osmosis water in the dialysate preparation system to the second concentrated solution and reverse osmosis water mixing point, and the x% is the allowable volume during the dialysate preparation process. The maximum fluctuation percentage of the real-time conductivity of the dialysate relative to the standard conductivity of the dialysate, the value range of x% is ±0.1 to ±5%.

Further, the exhaust operation is intermittent exhaust, and the single maximum exhaust volume is Vmax, and the intermittent exhaust is realized by intermittently opening and closing the degassing solenoid valve.

Preferably, in order to control the Vmax, the exhaust operation is intermittent exhaust, and the intermittent exhaust is realized by intermittently opening and closing the degassing electromagnetic valve, and the single opening time of the degassing electromagnetic valve is the longest is T1, and the T1 is calculated according to the following method:

T1=Vmax/F1

Among them, F1 is the degassing flow rate, and Vmax is the single maximum exhaust volume. In the specific implementation, by controlling each exhaust time to be less than or equal to T1, to ensure that the single exhaust volume is less than or equal to the single maximum exhaust volume Vmax, so as to avoid large fluctuations in the conductivity of the dialysate.

Further, the venting operation is intermittent venting, and the minimum interval between two venting processes is T0, and the T0 is determined according to the volume of the dialysate preparation system and the dialysate output flow in the dialysate preparation system.

Preferably, the minimum interval between two exhaust processes of the intermittent exhaust is T0, and the calculation method of T0 is as follows:

T0=V total/F0

Wherein, V is the total volume between the mixing point of the first concentrate and reverse osmosis water in the dialysate preparation system to the second concentrate and reverse osmosis water mixing point, and F0 is the dialysate output flow in the dialysate preparation system .

In a third aspect, the present invention also provides a dialysate preparation method, which includes a simultaneous preparation step and a degassing step, wherein the degassing step adopts the above-mentioned degassing method for the second mixing tank. The gas is removed, and the preparation steps specifically include:

The supply process is to transport the first concentrated liquid, the second concentrated liquid and the reverse osmosis water individually or in combination to the second mixing tank, wherein the first concentrated liquid and the second concentrated liquid are respectively supplied at a constant first flow rate and a second flow rate Transport to the direction of the second mixing tank;

A mixing process, mixing the first concentrated solution, the second concentrated solution and the reverse osmosis water delivered to the second mixing tank to form a dialysate;

The output process is to output the dialysate formed in the second mixing tank through the dialysate output pipeline at a constant output flow rate;

A detection process, using a second conductivity sensor to detect the conductivity of the dialysate output through the dialysate output pipeline to obtain the real-time conductivity of the dialysate;

Judging the execution process, judging whether the real-time conductivity is within the set threshold range, and suspending or terminating the output step when the real-time conductivity exceeds the set threshold range;

Compared with prior art, the beneficial effect of the present invention is:

In the first aspect, in the dialysate preparation system provided by the present invention, a degassing device is arranged on the top of the second mixing tank, and the first concentrated solution, the second concentrated solution and reverse osmosis water are processed in the second mixing tank. Mix and remove the air bubbles generated in the second mixing tank through the degassing device, so as to prevent the air bubbles from being output together with the dialysate, which can effectively improve the quality of the dialysate and ensure the safety of treatment. In addition, through Removing the air bubbles can also avoid the alarm of the dialysate system triggered by the air bubbles in the dialysate, and avoid the suspension or termination of treatment caused by it.

In the second aspect, a method for degassing dialysate provided by this aspect uses intermittent exhaust to remove the gas generated during the mixing process of the first concentrated liquid, the second concentrated liquid and reverse osmosis water, so that the gas can be removed while being excluded. Ensure that the concentration and conductivity of the dialysate meet the requirements, so as to ensure the quality of the dialysate.

In the third aspect, in the dialysate preparation method provided by the present invention, the liquid level in the second mixing tank is detected by a liquid level sensor installed in the second mixing tank to obtain the real-time liquid level, and the The real-time liquid level is monitored. When the real-time liquid level is lower than the preset liquid level, the exhaust operation is triggered, and part or all of the gas in the second mixing tank is emptied by intermittent exhaust. In order to achieve the exhaust effect.

By adopting a dialysate preparation system, dialysate preparation and degassing method provided by the present invention, the equipment composition of the dialysate preparation system can be greatly simplified, but it is still possible to treat a small amount of possible presence in the A concentrate and the B concentrate. Gas is removed to ensure the safety and efficiency of dialysis treatment.

Description of drawings

Fig. 1 is the overall structure schematic diagram of the dialysate preparation system in the prior art provided by the background technology of the present invention;

2 is a schematic diagram of the overall structure of a dialysate preparation system provided in Embodiment 1 of the present invention;

3 is a schematic diagram of the overall structure of a dialysate preparation system provided in Embodiment 3 of the present invention;

4 is a schematic diagram of the overall structure of a dialysate preparation system provided in Embodiment 4 of the present invention;

Reference numerals are: 10, the first concentrated liquid input pipeline, 11, the first output pump, 13, the first concentrated liquid storage tank, 20, the second concentrated liquid input pipeline, 21, the second output pump, 23, the second Concentrate storage tank, 30, reverse osmosis water input pipeline, 40, dialysate output pipeline, 41, dialysate output pump, 42, second conductivity sensor, 50, first mixing tank, 51, first liquid inlet port, 521, Upper outlet, 522, lower outlet, 53, premix liquid passage, 531, first passage, 532, second passage, 532a, first conductivity sensor, 60, second mixing tank, 61, second liquid inlet port, 62, Dialysate outlet, 63, gas collection part, 631, gas outlet, 70, negative pressure exhaust pipeline, 71, degassing solenoid valve, 72, negative pressure degassing pump, 73, liquid level sensor.

Detailed ways

Embodiments of the technical solutions of the present invention will be described in detail below in conjunction with the accompanying drawings. The following examples are only used to illustrate the technical solutions of the present invention more clearly, and therefore are only examples, rather than limiting the protection scope of the present invention.

Unless otherwise specified, in the present invention, if there are terms "length", "width", "upper", "lower", "front", "back", "left", "right", "vertical", Orientation or positional relationship indicated by "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. It is based on the orientation or positional relationship shown in the drawings, which are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, so this The terms describing the orientation or positional relationship in the invention are only used for illustrative purposes, and should not be construed as limitations on this patent. Those of ordinary skill in the art can understand the specific meanings of the above terms according to specific situations in conjunction with the accompanying drawings.

It should be noted that, in the present invention, the terms "inlet end" and "upstream" refer to the direction from which the fluid flows, and "downstream" and "outlet end" both refer to the direction to which the fluid flows.

Example 1

As shown in Figure 2, the present embodiment provides a dialysate preparation system, the dialysate preparation system includes a first concentrate input line 10, a first concentrate storage tank 13 arranged at the inlet end of the first concentrate input line 10 , the second concentrated liquid input line 20, the second concentrated liquid storage tank 23 arranged at the liquid inlet end of the second concentrated liquid input line 20, the reverse osmosis water input line 30, the second mixing tank 60 and the control unit, wherein the first The concentrated solution input line 10 is used to input the first concentrated solution to the second mixing tank 60, the second concentrated solution input line 20 is used to input the second concentrated solution to the second mixing tank 60, and the reverse osmosis water input line 30 is used to input the second concentrated solution to the second mixing tank 60. The reverse osmosis water is input into the mixing tank 60, and the first concentrated liquid is mixed with the reverse osmosis water before the second concentrated liquid to form a premixed liquid, and then the second concentrated liquid and the premixed liquid are mixed together and sent to the second mixing tank 60 The dialysate is mixed in the second mixing tank 60 to form a dialysate, and the dialysate is output through the dialysate output line 40. Specifically, the end of the dialysate output line 40 is connected to the dialysis treatment device. balance system. Here, it needs to be particularly noted that the internal structure of the second mixing tank 60 can be selected and set from the prior art to achieve uniform mixing of the first concentrate, the second concentrate and the reverse osmosis water. Therefore, the second The internal structure of the second mixing tank 60 will not be repeated in this embodiment and subsequent embodiments.

In this embodiment, in order to control the concentration of the dialysate prepared by the dialysate preparation system to meet the requirements, the first concentrated liquid input line 10 is provided with a first output pump 11, and the second concentrated liquid input line 20 A second output pump 21 is arranged on the top, and the first output pump 11 and the second output pump 21 are both electrically connected or signal connected to the control unit to control the output rates of the first concentrated liquid and the second concentrated liquid respectively, At the same time, in order to make the output rate of the dialysate controllable, the dialysate output line 40 is provided with a dialysate output pump 41, and the dialysate output pump 41 is electrically connected or signal-connected to the control unit to control the output of the dialysate. output flow. In addition, in order to control the quality of the dialysate, the dialysate output line 40 is also provided with a second conductivity sensor 42, the second conductivity sensor 42 is electrically or signally connected to the control unit, the second conductivity sensor 42 is used to detect the conductivity of the dialysate prepared in the dialysate preparation system to obtain the real-time conductivity. When the real-time conductivity is within the set threshold range, the dialysate prepared by the dialysate preparation system complies with Requirements, can be input into the balance system for use.

In this embodiment, since there may be a large number of air bubbles in the reverse osmosis water without degassing treatment, it is easy to cause the conductivity and concentration fluctuations in the dialysate preparation process to be too large. Therefore, the reverse osmosis water input pipeline input in this system 30 is provided with at least one reverse osmosis water degassing device (not shown in the accompanying drawings), thereby removing a large number of air bubbles existing in the reverse osmosis water, this reverse osmosis water degassing device can be selected from the prior art, and will not be carried out here repeat. At the same time, since a small amount of bubbles that may exist in the first concentrated solution and the second concentrated solution may be precipitated during the dialysate preparation process, in order to remove the above-mentioned bubbles, the dialysate preparation system is also provided with a degassing device. The device is connected to the top of the second mixing tank 60 and is used to remove the gas in the second mixing tank 60, so as to prevent the air bubbles in the second mixing tank 60 from following the dialysate and outputting into the balance system. Specifically, the bottom of the second mixing tank 60 is provided with a second liquid inlet port 61 to realize the input of the first concentrate, the second concentrate and reverse osmosis water, and the bottom of the second mixing tank 60 is provided with a dialysate outlet 62, the liquid inlet end of the dialysate output pipeline 40 is connected to the dialysate outlet 62, and at the same time, the top of the second mixing tank 60 is provided with a gas collection part 63, and the top of the gas collection part 63 is provided with a gas outlet 631 , the degassing device includes a negative pressure exhaust pipeline 70, and the negative pressure exhaust pipeline 70 is provided with a degassing solenoid valve 71 and a negative pressure degassing pump 72, and the degassing solenoid valve 71 and the negative pressure degassing pump The air pumps 72 are each electrically or signally connected to the control unit. The intake end of the negative pressure exhaust pipeline 70 is connected to the gas outlet 631 so as to discharge the gas in the second mixing tank 60 to the outside. More specifically, the cross-sectional area of the gas collection part 63 gradually decreases from bottom to top. Due to the setting of the gas collection part 63, the gas in the second mixing tank 60 is easy to collect into the second mixing tank 60. The top of the tank, so that the gas in the second mixing tank 60 can be easily discharged outside through the degassing device. During specific implementation, when air bubbles are generated in the second mixing tank 60, the air bubbles can float up and gather at the top of the gas collection part 63, and enter the negative pressure exhaust pipeline 70 through the gas outlet 631 to carry out exclude.

Example 2

Please refer to Figure 2. This embodiment provides a dialysate preparation method and a degassing method. The dialysate preparation method is implemented based on the dialysate preparation system provided in Example 1. The dialysate preparation method specifically includes simultaneous Preparation step and degassing step, wherein, the preparation step specifically includes:

Supply process: transport the first concentrated liquid, the second concentrated liquid and the reverse osmosis water to the second mixing tank 60 through the first concentrated liquid input pipeline 10 , the second concentrated liquid input pipeline 20 and the reverse osmosis water input pipeline 30 respectively, and The first concentrate and the second concentrate are transported at a constant first flow rate and a second flow rate respectively;

Mixing process: in the second mixing tank 60, the first concentrated solution, the second concentrated solution and the reverse osmosis water delivered to the second mixing tank 60 are mixed to form a dialysate with a relatively constant concentration and conductivity;

Output process: the dialysate formed in the second mixing tank 60 is exported at a constant output flow rate through the dialysate output line 40;

Detection process: in the dialysate output process, the second conductivity sensor 42 is used to detect the conductivity of the dialysate output through the dialysate output line 40 to obtain the real-time conductivity of the dialysate;

Judging the execution process; in the output process of the dialysate, it is judged whether the real-time conductivity of the dialysate is within the set threshold range, and when the real-time conductivity exceeds the set threshold range, it means that the dialysate prepared by the dialysate preparation system The dialysate does not meet the use standard, therefore, the control unit controls the dialysate output pump 41 to suspend or terminate the output step, so that the treatment process is suspended to ensure the safety of the dialysis treatment.

The degassing step is carried out according to the following degassing method:

S21: a detection step, detecting and obtaining the real-time liquid level height in the second mixing tank 60 in real time through the liquid level sensor 73 in the second mixing tank 60;

S22: Judging step, judging whether the real-time liquid level height is lower than the preset liquid level height;

S23: Execution step, judged by the judging step as the starting time point of the exhaust operation, at this time, the control unit controls the degassing device to work to perform the exhaust operation to eliminate the gas in the second mixing tank 60 until the When the liquid level in the second mixing tank 60 returns to H1, the exhaust operation is terminated. At this time, the exhaust operation is stopped. Specifically, the H1 is greater than the preset liquid level height, and the H1 is less than or equal to the maximum liquid level height in the second mixing tank 60, and the H1 is also passed through the second liquid level sensor 73 located in the second mixing tank 60 Monitor.

More specifically, after the gas in the second mixing tank 60 is discharged outwards, since the pressure in the second mixing tank 60 decreases, the reverse osmosis water is automatically replenished into the second mixing tank 60, when the When the reverse osmosis water replenishment volume is too large at a time, the dialysate concentration output by the second mixing tank 60 may not meet the requirements, thus causing the real-time conductivity detected by the second conductivity sensor 42 to exceed the set threshold range, and Terminate the dialysis treatment process. Therefore, the present embodiment uses the intermittent exhaust method to remove the gas in the second mixing tank 60. Specifically, the single maximum exhaust volume of the intermittent exhaust is Vmax, and the minimum interval time is T0, wherein the Vmax less than the maximum volume of a single supply of reverse osmosis water to the dialysate preparation system, the maximum volume refers to the replenishment of a certain volume of reverse osmosis water in the dialysate preparation system without causing the detection value of the second conductivity sensor 42 to exceed the set threshold range At the same time, in order to avoid the situation that the conductivity fluctuation of the dialysate exceeds the set threshold range caused by the short interval between the two exhausting processes, the intermittent exhausting needs to be controlled twice. The time interval between air processes is greater than or equal to the minimum interval time TO.

In this embodiment, a calculation method for a single maximum exhaust volume Vmax and a minimum time interval T0 is also provided, respectively as follows:

Vmax=Vtotal*x%

Wherein, V total should be the total volume of the pipeline between the mixing point of the first concentrated solution and reverse osmosis water in the dialysate preparation system to the mixing point of the second concentrated solution and reverse osmosis water, and the x% is according to the preparation standard of dialysate It is set that the value range is ±0.1-±5%, and preferably ±2.5%, so as to ensure that the sodium ion concentration and other solute concentrations in the prepared dialysate meet the use standards. Specifically, the intermittent exhaust is realized by intermittently controlling the opening and closing of the degassing solenoid valve 71. When the degassing solenoid valve 71 is opened, it cooperates with the negative pressure degassing pump 72 to work from the second mixing A certain volume of gas is discharged outwards from the tank 60. During this process, the maximum time for a single opening of the degassing solenoid valve 71 is , which is calculated according to the following method:

T1=Vmax/F1

Among them, F1 is the degassing flow rate, which is determined by the negative pressure degassing pump 72. Specifically, in the actual implementation process, the degassing flow rate F1 can be controlled to be constant, and then the degassing solenoid valve 71 is controlled to open each time. The time is less than or equal to T1, so as to ensure that the single exhaust volume during intermittent exhaust is less than or equal to the single maximum exhaust volume Vmax, so as to avoid large fluctuations in the conductivity of the dialysate, so that the degassing can be guaranteed at the same time The conductivity of the dialysate fluctuates within a set threshold to ensure the safety of the treatment without interrupting or discontinuing the treatment process.

During this process, in order to avoid excessive fluctuations in the conductivity of the dialysate caused by frequent degassing, this embodiment also provides a calculation method for T0, specifically:

T0=V total/F0

Wherein, V is the total volume of the pipeline between the mixing point of the first concentrate and reverse osmosis water in the dialysate preparation system to the second concentrate and reverse osmosis water mixing point, and F0 is the dialysis volume in the dialysate preparation system. Liquid output flow.

In the dialysate preparation method provided in this embodiment, during the preparation process of the dialysate, since the ratio of solute and solvent in the dialysate used for treatment is relatively constant, the first delivery pump, the second delivery pump and the dialysis The liquid output pumps 41 all operate at a constant flow rate, and at the same time, since the volumes of the tanks and pipelines that make up the dialysate preparation system are constant, the volume of gas discharged from the second mixing tank 60 passes through to all Reverse osmosis water is supplemented in the above-mentioned dialysate preparation system, so that the prepared dialysate concentration and conductivity meet the requirements. Therefore, in this embodiment, by adopting the method of intermittent exhaust, and controlling the single maximum exhaust volume and The minimum time interval between two adjacent degassing processes makes the volume of reverse osmosis water entering the dialysate preparation system reasonable during each degassing, avoiding the concentration of dialysate caused by a single replenishment of reverse osmosis water volume too large The system alarms caused by excessive fluctuations and the treatment process is interrupted, and the safety of the treatment process can be guaranteed.

Example 3

As shown in Figure 3, this embodiment provides a dialysate preparation system, the difference between the dialysate preparation system and the dialysate preparation system provided in Example 1 is that:

A dialysate preparation system provided in this embodiment further includes a first mixing tank 50, the first mixing tank 50 is arranged downstream of the first concentrate input line 10 and the reverse osmosis water input line 30, and is located in the The upstream of the second concentrated liquid input line 20 and the second mixing tank 60, the first mixing tank 50 is used to premix the first concentrated liquid and reverse osmosis water to form a premixed liquid, and the first mixing tank 50 passes The premixed liquid channel 53 transports the premixed liquid to the second mixing tank 60 to be mixed with the second concentrated liquid again.

In this embodiment, due to the setting of the first mixing tank 50, the first concentrated liquid can be pre-mixed with the reverse osmosis water in the first mixing tank 50, thereby improving the mixing effect.

Example 4

As shown in Figure 3, this embodiment provides a dialysate preparation system, which differs from the dialysate preparation system provided in Example 1 in that the dialysate preparation system provided by this embodiment also includes a first mixing The tank 50, the first conductance sensor 532a, the premix liquid passage 53 composed of the first passage 531 and the second passage 532, and the control unit. In this dialysate preparation system, the first output pump 11, the second output pump 21, the dialysis The liquid output pump 41, the first conductance sensor 532a, the second conductance sensor 42, the degassing solenoid valve 71 and the negative pressure degassing pump 72 are all electrically or signally connected to the control unit to realize the automatic preparation and degassing of the dialysate .

In this embodiment, the first mixing tank 50 is used to realize the primary mixing of the first concentrated liquid and the reverse osmosis water, specifically, the bottom of the first mixing tank 50 is provided with a first liquid inlet port 51, the first The liquid inlet interface 51 is used to realize the input of the first concentrate and reverse osmosis water. The top of the first mixing tank 50 is provided with an upper outlet 521, and the bottom of the first mixing tank 50 is provided with a lower outlet 522. The premixed liquid The passage 53 includes a first passage 531 and a second passage 532, the first passage 531 is used to connect the upper outlet 521 and the second mixing tank 60, and the second passage 532 is used to communicate with the lower outlet 522 and the second mixing tank 60. In the second mixing tank 60 , the first conductivity sensor 532 a is disposed on the second passage 532 . In addition, the diameter of the lower outlet 522 of the first mixing tank 50 is larger than that of the upper outlet 521 , so that the liquid in the first mixing tank 50 can easily enter the second passage 532 . In a specific implementation, in the first mixing tank 50, the first concentrate and reverse osmosis water are mixed to form a premixed solution, and most of the premixed solution is delivered to the second mixing tank 60 through the second passage 532, while A small part of the premixed liquid and the air bubbles generated in the first mixing tank 50 are delivered to the second mixing tank 60 through the first passage 531. In the process, in order to further avoid residual gas in the first mixing tank 50 and make the The air bubbles in the first mixing tank 50 are more likely to enter the first passage 531, and the top of the first mixing tank 50 is also provided with a gas collection part 63 with the same structure as the second mixing tank 60, so that the air bubbles are mixed by the first mixing tank 50. During the transfer of the tank 50 to the second mixing tank 60, the monitoring of the first conductivity sensor 532a can be skipped, so as to avoid the output suspension of the dialysate preparation system caused by the abnormal detection value of the first conductivity sensor 532a. At this time, due to the setting of the first conductivity sensor 532a, the conductivity of the premixed liquid formed in the first mixing tank 50 can be preliminarily detected. The conductivity sensor 532a initially monitors the conductivity of the premixed solution, so as to more accurately control the ratio of the B concentrated solution in the dialysate.

In this embodiment, in order to control the degassing process, a liquid level sensor 73 is provided inside the second mixing tank 60, and the liquid level sensor 73 is used to monitor the liquid in the second mixing tank 60 in real time. position to obtain the real-time liquid level height.

Example 5

Please refer to Figure 4. This embodiment provides a dialysate preparation method and a degassing method. The dialysate preparation method is implemented based on the dialysate preparation system provided in Example 4. The dialysate preparation method specifically includes simultaneous Preparation step and degassing step, wherein, the preparation step specifically includes:

Supply process: transport the first concentrated liquid and reverse osmosis water to the first mixing tank 50 for premixing to form a premixed liquid, most of the premixed liquid in the first mixing tank 50 is sent to the second mixing tank through the second passage 532 60 and in this process, the conductivity of the premixed liquid is monitored by the first conductivity sensor 532a to improve the precision of liquid distribution, and a small part of the premixed liquid in the first mixing tank 50 and the first mixing tank 50 A small amount of air bubbles in the gas are transported to the second mixing tank 60 through the first passage 531, and during this process, both the first output pump 11 and the second output pump 21 are transported at a constant flow rate;

Mixing process: in the second mixing tank 60, the second concentrated solution and the premixed solution delivered to the second mixing tank 60 are mixed again to form a dialysate with a relatively constant concentration and conductivity;

Output process: the dialysate formed in the second mixing tank 60 is exported at a constant output flow rate through the dialysate output line 40;

Detection process: in the dialysate output process, the second conductivity sensor 42 is used to detect the conductivity of the dialysate output through the dialysate output line 40 to obtain the real-time conductivity of the dialysate;

Judging the execution process; in the output process of the dialysate, it is judged whether the real-time conductivity is within the set threshold range. When the real-time conductivity exceeds the set threshold range, it means that the dialysate prepared by the dialysate preparation system is not suitable for use. Standard, therefore, the control unit controls the dialysate output pump 41 to suspend or terminate the output step, so that the treatment process is suspended to ensure the safety of the dialysis treatment.

In the dialysate preparation method provided in this embodiment, the preparation steps are summarized as follows: the first concentrated liquid and reverse osmosis water are transported to the first mixing tank 50 for mixing, and most of the premixed liquid formed after mixing is obtained from the The bottom of the first mixing tank 50 flows out and is delivered to the second mixing tank 60 through the second passage 532. During this process, the first conductivity sensor 532a can monitor the conductivity of the premix in real time. When the first When the detection value of the conductance sensor 532a is abnormal, it means that the proportion of the reverse osmosis water and the first concentrated solution is improper. At this time, the control unit controls the output process of the dialysate to suspend or stop to ensure the safety of treatment; when the first conductance sensor When the detection value of 532a is normal, each liquid in the system flows normally and the premixed liquid and the second concentrated liquid are mixed again in the second mixing tank to prepare it as a dialysate, which is passed through the dialysate When the output pipeline 40 is exported, the conductivity of the dialysate is monitored again by the second conductivity sensor 42 to ensure the safety of treatment. In the above-mentioned preparation steps, when the detection value of any one of the first conductivity sensor 532a and the second conductivity sensor 42 is abnormal, the control unit controls the dialysate output pump 41 to suspend or terminate the output step, so that the treatment process Pause or discontinue to ensure safe treatment.

In order to further improve the safety of the dialysate preparation system, the dialysate preparation system also includes an alarm, the alarm is electrically or signally connected to the control unit, when the first conductance sensor 532a and the second conductance sensor When any of the detected values in 42 is abnormal, the control unit controls the alarm to send out prompt information, and the prompt information can be any one of sound and light signals.

The degassing step is carried out according to the following degassing method:

S21: a detection step, detecting and obtaining the real-time liquid level height in the second mixing tank 60 in real time through the liquid level sensor 73 in the second mixing tank 60;

S22: Judging step, judging whether the real-time liquid level height is lower than the preset liquid level height;

S23: Execution step, judged by the judging step as the starting time point of the exhaust operation, at this time, the control unit controls the degassing device to work to perform the exhaust operation to eliminate the gas in the second mixing tank 60 until the When the liquid level in the second mixing tank 60 returns to H1, the exhaust operation is terminated. At this time, the exhaust operation is stopped. Specifically, the H1 is greater than the preset liquid level height, and the H1 is less than or equal to the maximum liquid level height in the second mixing tank 60, and the H1 is also passed through the second liquid level sensor 73 located in the second mixing tank 60 Monitor.

More specifically, when the gas in the second mixing tank 60 is discharged to the outside, since the pressure in the second mixing tank 60 decreases, the reverse osmosis water in the system is automatically replenished to the second mixing tank 60 In this case, when the reverse osmosis water replenishment volume is too large, the dialysate concentration output by the second mixing tank 60 may not meet the requirements, thus causing the real-time conductivity detected by the second conductivity sensor 42 to exceed the set value. Threshold range, and the dialysis treatment process is terminated. Therefore, the present embodiment adopts the intermittent exhaust method to remove the gas in the second mixing tank 60. Specifically, the single maximum exhaust volume of the intermittent exhaust is Vmax, and its minimum interval is, wherein, the Vmax is less than The maximum volume of reverse osmosis water added to the dialysate preparation system for a single time, the maximum volume refers to when a certain volume of reverse osmosis water is added to the dialysate preparation system without causing the detection value of the second conductivity sensor 42 to exceed the set threshold range The maximum volume of reverse osmosis water that is allowed to be replenished. At the same time, in order to avoid the situation that the conductivity fluctuation of the dialysate exceeds the set threshold range caused by the short interval between the two exhaust processes, the intermittent exhaust also needs to be controlled twice. The time interval between processes is greater than or equal to the minimum interval time T0.

In this embodiment, a method for calculating the sum is also specifically provided, which are as follows:

Vmax=Vtotal*x%

Wherein, the V total is the total volume of the pipeline between the mixing point of the first concentrated liquid and reverse osmosis water to the mixing point of the second concentrated liquid and reverse osmosis water and the first mixing tank 50 in the dialysate preparation system, and the x % is set according to the preparation standard of the dialysate, the value range of this x% is ±0.1～±5%, and preferably ±2.5%, to ensure that the sodium ion concentration and the concentration of other solutes in the prepared dialysate are uniform Comply with usage standards.

In this embodiment, the intermittent exhaust is realized by intermittently controlling the opening and closing time of the degassing solenoid valve 71. When the degassing solenoid valve 71 is opened, it cooperates with the negative pressure degassing pump 72 to work from A certain volume of gas is discharged from the second mixing tank 60, and then the degassing solenoid valve 71 is closed to form an exhaust cycle. In this intermittent exhaust method, a plurality of exhaust cycles are cycled until the second The liquid level in the mixing tank 60 returns to H1, and at this time, the exhaust operation is stopped. In this process, the longest single opening time of the degassing solenoid valve 71 is T1, which is calculated according to the following method:

T1=Vmax/F1

Among them, F1 is the degassing flow rate, which is determined by the negative pressure degassing pump 72. Specifically, in the actual implementation process, it can be controlled by controlling the degassing flow rate to be constant, and then controlling the opening of the degassing solenoid valve 71 each time. The time is less than or equal to T1 to ensure that the single exhaust volume during intermittent exhaust is less than or equal to the single maximum exhaust volume Vmax, so as to avoid large fluctuations in the conductivity of the dialysate, so that dialysis can be guaranteed while degassing The conductivity of the fluid fluctuates within a set threshold to ensure the safety of the treatment without interrupting or discontinuing the treatment process.

During this process, in order to avoid excessive fluctuations in the conductivity of the dialysate caused by frequent degassing and replenishment of reverse osmosis water, this embodiment also provides a calculation method for the minimum time interval T0, specifically:

T0=V total/F0

Wherein, V is always the total volume of the pipeline between the mixing point of the first concentrated solution and reverse osmosis water to the mixing point of the second concentrated solution and reverse osmosis water in the dialysate preparation system and the first mixing tank 50, and F0 is The dialysate output flow in the dialysate preparation system is determined by the dialysate output pump 41 .

In the dialysate preparation method provided in this embodiment, the degassing steps are summarized as follows: During the treatment process, the dialysate preparation system is in the liquid preparation mode, and when the air enters the second mixing tank 60, the liquid level drops until the The real-time liquid level in the second mixing tank 60 is lower than the preset liquid level. At this time, the control unit controls the degassing device to work to enter the exhaust operation, so as to ensure the preparation quality of the dialysate in the exhaust operation. , the exhaust operation is intermittent exhaust, and the single maximum exhaust volume is controlled as Vmax during the intermittent exhaust process. When the single exhaust process ends, start counting at this time until the exhaust time interval is equal to or greater than the minimum At intervals, degassing can be performed again until the liquid level in the second mixing tank 60 returns to H1, then the degassing is stopped.

When the dialysate preparation system is in the non-dispensing mode, since there is no need to ensure the stability of the solute concentration in the dialysate preparation system, it is necessary to discharge the gas in the mixing tank in time, and the exhaust process can adopt continuous exhaust instead of Use the above method for intermittent exhaust to improve exhaust efficiency.

The above embodiments are only used to illustrate the technical solutions of the present invention without limitation. Although the present invention has been described in detail with reference to preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present invention can be modified or equivalently replaced. Without departing from the purpose and scope of the technical solutions of the present invention, all of them should be included in the scope of the claims of the present invention. The technologies, shapes and construction parts not described in detail in the present invention are all known technologies.

Claims (18)

1. A dialysate preparation system, characterized in that, comprising: The first concentrated liquid input pipeline (10), is used for inputting the first concentrated liquid; The second concentrated solution input pipeline (20), is used for inputting the second concentrated solution; Reverse osmosis water input pipeline (30), used for inputting reverse osmosis water; The second mixing tank (60), the second mixing tank (60) is used to mix the first concentrated solution, the second concentrated solution and reverse osmosis water to form a dialysate, and the second mixing tank (60) is used for dialysis The liquid output pipeline (40) outputs the dialysate to the outside; The degassing device is connected to the top of the second mixing tank (60) and used for removing the gas in the second mixing tank (60). 2. A dialysate preparation system according to claim 1, characterized in that: the dialysate output line (40) is provided with a second conductivity sensor (42). 3. A kind of dialysate preparation system as claimed in claim 1, is characterized in that, also comprises: The first mixing tank (50), the first mixing tank (50) is located at the downstream of the first concentrate input line (10) and reverse osmosis water input line (30), the first mixing tank (50) It is used for premixing the first concentrated liquid and reverse osmosis water to form a premixed liquid, and the first mixing tank (50) sends the premixed liquid to the second mixing tank (60) through the premixed liquid channel (53). 4. A kind of dialysate preparation system as claimed in claim 3, is characterized in that: the top of described first mixing tank (50) is provided with upper end outlet (521), and the bottom of described first mixing tank (50) A lower outlet (522) is provided, and the premix passage (53) includes a first passage (531) and a second passage (532), and the first passage (531) is used to communicate with the upper outlet (521) and The second mixing tank (60), the second passage (532) is used to communicate with the lower outlet (522) and the second mixing tank (60), and the second passage (532) is provided with a first conductivity sensor (532a). 5. A kind of dialysate preparation system as claimed in claim 1, is characterized in that: the bottom of described second mixing tank (60) is provided with dialysate outlet (62), and the dialysate output line (40) The liquid inlet end is connected to the dialysate outlet (62); the top of the second mixing tank (60) is provided with a gas outlet (631), and one end of the degassing device is connected to the gas outlet (631). 6. A kind of dialysate preparation system as claimed in claim 1, is characterized in that: described degassing device comprises negative pressure exhaust pipeline (70), and described negative pressure exhaust pipeline (70) is provided with Degassing solenoid valve (71) and negative pressure degassing pump (72). 7. The dialysate preparation system according to claim 1, characterized in that: a liquid level sensor (73) is arranged inside the second mixing tank (60). 8. A kind of dialysate preparation system as claimed in claim 1, is characterized in that: also comprise control unit, described first concentrated solution input pipeline (10) and the second concentrated solution input pipeline (20) are respectively provided with The first output pump (11) and the second output pump (21), the first output pump (11), the second output pump (21), the second conductivity sensor (42) and the degassing device are all electrically connected or signal connected to the control unit. 9. A dialysate degassing method, characterized in that: S21: detection step, detecting and acquiring the real-time liquid level in the second mixing tank (60); S22: Judging step, judging whether the real-time liquid level height is lower than the preset liquid level height; S23: Execution step, when the judgment step is judged to be yes, start the degassing device to perform an exhaust operation to remove the gas in the second mixing tank (60). 10. A kind of dialysate degassing method as claimed in claim 9, it is characterized in that, described S23 is specifically: when described judging step is judged to be, start degassing device and carry out exhaust operation to get rid of the second mixing The gas in the tank (60) until the liquid level in the second mixing tank (60) returns to H1, and the H1 is greater than the preset liquid level. 11. A dialysate degassing method as claimed in claim 9, characterized in that: the exhaust operation is intermittent exhaust. 12. A dialysate degassing method as claimed in claim 11, characterized in that: the exhaust operation is intermittent exhaust, and the single maximum exhaust volume is Vmax, and the Vmax is less than or equal to the The maximum volume of a single replenishment of reverse osmosis water in the dialysate preparation system, the maximum volume of the single replenishment of reverse osmosis water refers to the replenishment of a certain volume of reverse osmosis water in the dialysate preparation system without causing the detection value of the second conductivity sensor (42) The maximum volume of reverse osmosis water that is allowed to be replenished when the set threshold range is exceeded. 13. A kind of dialysate degassing method as claimed in claim 11, is characterized in that: described exhaust operation is intermittent exhaust, and single maximum exhaust volume is Vmax, and described Vmax is calculated by the following manner: Vmax=Vtotal*x% Wherein, the V total is the total volume between the mixing point of the first concentrated solution and reverse osmosis water in the dialysate preparation system to the second concentrated solution and reverse osmosis water mixing point, and the x% is the allowable volume during the dialysate preparation process. The maximum fluctuation percentage of the real-time conductivity of the dialysate relative to the standard conductivity of the dialysate, the value range of x% is ±0.1 to ±5%. 14. a kind of dialysate degassing method as claimed in claim 13, is characterized in that: described exhaust operation is intermittent exhaust, and single maximum exhaust volume is Vmax, and described intermittent exhaust is passed intermittently The opening and closing of the degassing solenoid valve is realized. 15. A kind of dialysate degassing method as claimed in claim 14, is characterized in that: described exhaust operation is intermittent exhaust, and described intermittent exhaust is realized by intermittently opening and closing degassing electromagnetic valve, and single The second maximum displacement is Vmax, and the longest single opening time of the degassing solenoid valve is T1, and the T1 is calculated according to the following method: T1=Vmax/F1 Among them, F1 is the degassing flow rate, and Vmax is the single maximum exhaust volume. 16. A dialysate degassing method as claimed in claim 9, characterized in that: the exhaust operation is intermittent exhaust, and the minimum interval between two exhaust processes is T0, and the T0 is based on The dialysate preparation system volume and the dialysate output flow in the dialysate preparation system are determined. 17. A kind of dialysate degassing method as claimed in claim 16, it is characterized in that: described exhaust operation is intermittent exhaust, and the minimum interval time between two exhaust processes is T0, and the T0 The calculation method is as follows: T0=V total/F0 Wherein, V is the total volume between the mixing point of the first concentrate and reverse osmosis water in the dialysate preparation system to the second concentrate and reverse osmosis water mixing point, and F0 is the dialysate output flow in the dialysate preparation system . 18. A dialysate preparation method, characterized in that it comprises a simultaneous preparation step and a degassing step, wherein the degassing step adopts the degassing method described in any one of claims 9-17 to mix the second The gas in the tank (60) is removed, and the preparation step specifically includes: The supply process is to transport the first concentrated liquid, the second concentrated liquid and the reverse osmosis water to the second mixing tank (60) individually or in combination, wherein the first concentrated liquid and the second concentrated liquid are respectively supplied at a constant first flow rate and The second flow rate is delivered to the direction of the second mixing tank (60); A mixing process, mixing the first concentrated solution, the second concentrated solution and the reverse osmosis water delivered to the second mixing tank (60) to form a dialysate; Output process, the dialysate formed in the second mixing tank (60) is exported to the outside at a constant output flow rate through the dialysate output pipeline (40); The detection process is to detect the conductivity of the dialysate outputted through the dialysate output pipeline (40) to obtain the real-time conductivity of the dialysate; Judging the execution process, judging whether the real-time conductivity is within the set threshold range, and suspending or terminating the output step when the real-time conductivity exceeds the set threshold range.

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