CN114949147B - A traditional Chinese medicine composition for treating chronic pharyngitis, its preparation method and application - Google Patents

Abstract

The invention provides a traditional Chinese medicine composition for treating chronic pharyngitis, which includes the following raw materials in parts by mass: 10 to 30 parts of Scrophulariaceae, 5 to 15 parts of Platycodon, 8 to 10 parts of Pediculus, 8 to 10 parts of Malinda root, and licorice. 8 to 10 parts, Pinellia 8 to 10 parts, Trachelospermia 10 to 20 parts, Magnolia officinalis 5 to 9 parts, Perilla stems 8 to 10 parts, Burdock 8 to 10 parts, Trichosanthes 10 to 20 parts, 10 to 20 parts of Zedoary, 5 to 9 parts of Shegan, 8 to 10 parts of Poria, and 3 to 6 parts of Wood Butterfly. The present invention combines the above components and proportions with a specific extraction method to create a traditional Chinese medicine composition for treating chronic pharyngitis, which has the technical effects of simple formula, quick effect, strong medicinal effect, and no toxic or side effects.

Description

A traditional Chinese medicine composition for treating chronic pharyngitis, its preparation method and application

Technical field

The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating chronic pharyngitis, its preparation method and application.

Background technique

Chronic pharyngitis is a chronic inflammation of the pharyngeal mucosa, submucosal and lymphoid tissues. Diffuse pharyngeal inflammation is often part of the chronic inflammation of the upper respiratory tract; localized pharyngeal inflammation is mostly inflammation of the pharyngeal lymphoid tissue. This disease is common in clinical practice, has a long course, and is prone to recurring symptoms.

Chronic pharyngitis is more common in adults but can also occur in children. The systemic symptoms are not obvious, and local symptoms are the main ones. The symptoms of various types of chronic pharyngitis are similar and varied, such as pharyngeal discomfort, foreign body sensation, difficulty in spitting out pharyngeal secretions, pharyngeal itching, burning, dryness or irritation, and even slight pain. Because thicker secretions usually adhere to the posterior pharyngeal wall due to chronic inflammation of the pharynx, and mouth breathing occurs at night due to lesions in the nose, sinuses, and nasopharynx, irritating coughs and nausea often occur in the morning. Foreign body sensation in the pharynx may manifest as frequent swallowing. People with few pharyngeal secretions that are difficult to cough up often manifest themselves as habitual dry coughs and throat-clearing movements to expectorate phlegm. Coughing or clearing the throat forcefully can cause bleeding of the pharyngeal mucosa, causing blood in the secretions.

Therefore, it is very necessary to provide a traditional Chinese medicine composition that has good curative effect, quick effect, strong medicinal effect, is not easy to relapse, and can effectively solve the problem of chronic pharyngitis.

Contents of the invention

In view of this, the technical problem to be solved by the present invention is to provide a traditional Chinese medicine composition for treating chronic pharyngitis. The composition provided by the present invention has quick effect, strong medicinal effect and no toxic or side effects.

The invention provides a traditional Chinese medicine composition for treating chronic pharyngitis, including the following raw materials in parts by mass:

10 to 30 parts of Scrophulariaceae, 5 to 15 parts of Platycodon, 8 to 10 parts of Pediculus, 8 to 10 parts of Malinda root, 8 to 10 parts of licorice, 8 to 10 parts of Pinellia ternata, 10 to 20 parts of Trachelospermia. 5 to 9 parts of Magnolia officinalis, 8 to 10 parts of Perilla stalks, 8 to 10 parts of Arctium lappa, 10 to 20 parts of Trichosanthes rhizome, 10 to 20 parts of Curcuma zedoary, 5 to 9 parts of Radix Scutellariae, 8 to 10 parts of Poria, and 3 parts of Poria. ~6 servings.

Preferably, the traditional Chinese medicine composition for treating chronic pharyngitis includes the following parts by mass of raw materials:

10 parts of Scrophulariaceae, 5 parts of Platycodon, 8 parts of Pediculus, 8 parts of Malinda root, 8 parts of Licorice, 8 parts of Pinellia, 10 parts of Trachelospermia, 5 parts of Magnolia officinalis, 8 parts of Perilla stems, 8 parts of Arctium lappa. 10 parts of Trigonella striata, 10 parts of Curcuma zedoaria, 5 parts of Shegan, 8 parts of Poria cocos, and 3 parts of Wood Butterfly.

Preferably, the traditional Chinese medicine composition for treating chronic pharyngitis includes the following parts by mass of raw materials:

20 parts of Scrophulariaceae, 10 parts of Platycodon, 9 parts of Pediculus, 9 parts of Malinda root, 9 parts of Licorice, 9 parts of Pinellia ternata, 15 parts of Trachelospermia, 6 parts of Magnolia officinalis, 9 parts of Perilla stems, 9 parts of Arctium lappa. There are 15 parts of Trigonella striata, 15 parts of Curcuma zedoaria, 6 parts of Shegan, 9 parts of Poria cocos and 5 parts of Wood butterfly.

Preferably, the traditional Chinese medicine composition for treating chronic pharyngitis includes the following parts by mass of raw materials:

30 parts of Scrophulariaceae, 15 parts of Platycodon, 10 parts of Frontendax, 10 parts of Malinda root, 10 parts of Licorice, 10 parts of Pinellia ternata, 20 parts of Trachelospermia, 9 parts of Magnolia officinalis, 10 parts of Perilla stems, 10 parts of Burdock. 20 parts of Trigonella striata, 20 parts of Curcuma zedoaria, 9 parts of Shegan, 10 parts of Poria cocos, and 6 parts of Wood butterfly.

The present invention provides a method for preparing a traditional Chinese medicine composition for treating chronic pharyngitis according to any one of the above technical solutions, which includes the following steps:

Mix Scrophulariaceae, Platycodon, Pediculus, Maltroot, Licorice, Pinellia, Trachelospermia, Magnolia officinalis, Perilla stalk, Arctium lappa, Trigonella, Curcuma, Shegan, Poria and Wood butterfly, heat for the first time Decoct and filter to obtain the first medicinal liquid. Decoct again and combine the medicinal liquids to get it.

Preferably, the sum of Scrophulariaceae, Platycodon, Pediculus, Malinda root, licorice, Pinellia pinellia, Trachelospermia, Magnolia officinalis, Perilla stalk, Arctium lappa, Trigonella, Curcuma, Shegan, Poria and Wood butterfly. The mass ratio to water is 1:5.

Preferably, the first decoction time is 1 to 1.5 hours; the second decoction time is 30 to 40 minutes.

The present invention provides the use of any of the above-mentioned traditional Chinese medicine compositions in preparing products for treating chronic pharyngitis.

The invention provides a product for treating chronic pharyngitis, including the traditional Chinese medicine composition described in any one of the above technical solutions.

Preferably, the dosage form of the product is decoction, tablet, capsule, granule or pill.

Compared with the existing technology, the present invention provides a traditional Chinese medicine composition for treating chronic pharyngitis, including the following raw materials in parts by mass: 10 to 30 parts of Scrophulariaceae, 5 to 15 parts of Platycodon, 8 to 10 parts of Pediculus, and Malin. 8 to 10 parts of root, 8 to 10 parts of licorice, 8 to 10 parts of Pinellia ternata, 10 to 20 parts of Trachelospermia vine, 5 to 9 parts of Magnolia officinalis, 8 to 10 parts of perilla stems, 8 to 10 parts of burdock. 10 to 20 parts of Trigonella, 10 to 20 parts of Curcuma, 5 to 9 parts of Shegan, 8 to 10 parts of Poria, and 3 to 6 parts of Wood Butterfly. The present invention combines the above components and proportions with a specific extraction method to create a traditional Chinese medicine composition for treating chronic pharyngitis, which has the technical effects of simple formula, quick effect, strong medicinal effect, and no toxic or side effects.

Detailed ways

The present invention provides a traditional Chinese medicine composition for treating chronic pharyngitis, its preparation method and application. Those skilled in the art can learn from the contents of this article and appropriately improve the process parameters to achieve it. It should be pointed out in particular that all similar substitutions and modifications are obvious to those skilled in the art, and they all fall within the protection scope of the present invention. The methods and applications of the present invention have been described through preferred embodiments. Relevant persons can obviously modify or appropriately change and combine the methods and applications herein without departing from the content, spirit and scope of the present invention to implement and apply the present invention. Invent technology.

The invention provides a traditional Chinese medicine composition for treating chronic pharyngitis, including the following raw materials in parts by mass:

10 to 30 parts of Scrophulariaceae, 5 to 15 parts of Platycodon, 8 to 10 parts of Pediculus, 8 to 10 parts of Malinda root, 8 to 10 parts of licorice, 8 to 10 parts of Pinellia ternata, 10 to 20 parts of Trachelospermia. 5 to 9 parts of Magnolia officinalis, 8 to 10 parts of Perilla stalks, 8 to 10 parts of Arctium lappa, 10 to 20 parts of Trichosanthes rhizome, 10 to 20 parts of Curcuma zedoary, 5 to 9 parts of Radix Scutellariae, 8 to 10 parts of Poria, and 3 parts of Poria. ~6 servings.

Note: The traditional Chinese medicine of the present invention uses the stems of perilla, namely perilla stems, instead of perilla leaves.

In some preferred embodiments of the present invention, the traditional Chinese medicine composition for treating chronic pharyngitis includes the following raw materials in parts by mass:

10 parts of Scrophulariaceae, 5 parts of Platycodon, 8 parts of Pediculus, 8 parts of Malinda root, 8 parts of Licorice, 8 parts of Pinellia, 10 parts of Trachelospermia, 5 parts of Magnolia officinalis, 8 parts of Perilla stems, 8 parts of Arctium lappa. 10 parts of Trigonella striata, 10 parts of Curcuma zedoaria, 5 parts of Shegan, 8 parts of Poria cocos, and 3 parts of Wood Butterfly.

In some preferred embodiments of the present invention, the traditional Chinese medicine composition for treating chronic pharyngitis includes the following raw materials in parts by mass:

20 parts of Scrophulariaceae, 10 parts of Platycodon, 9 parts of Pediculus, 9 parts of Malinda root, 9 parts of Licorice, 9 parts of Pinellia ternata, 15 parts of Trachelospermia, 6 parts of Magnolia officinalis, 9 parts of Perilla stems, 9 parts of Arctium lappa. There are 15 parts of Trigonella striata, 15 parts of Curcuma zedoaria, 6 parts of Shegan, 9 parts of Poria cocos and 5 parts of Wood butterfly.

In some preferred embodiments of the present invention, the traditional Chinese medicine composition for treating chronic pharyngitis includes the following raw materials in parts by mass:

30 parts of Scrophulariaceae, 15 parts of Platycodon, 10 parts of Frontendax, 10 parts of Malinda root, 10 parts of Licorice, 10 parts of Pinellia ternata, 20 parts of Trachelospermia, 9 parts of Magnolia officinalis, 10 parts of Perilla stems, 10 parts of Burdock. 20 parts of Trigonella striata, 20 parts of Curcuma zedoaria, 9 parts of Shegan, 10 parts of Poria cocos, and 6 parts of Wood butterfly.

The invention is rich in raw materials and has a scientific and reasonable formula. By combining the raw materials with specific proportions and synergistically functioning, the invention can treat both the symptoms and the root causes, clearing the lungs and regulating qi, resolving phlegm and relieving coughs, warming the body and soothing the throat, and has no toxic or side effects. In terms of chronic pharyngitis, it has many advantages such as good curative effect, quick effect, strong medicinal effect, and difficulty in recurrence. It can effectively solve the problem of treatment and medication of chronic pharyngitis.

The inventor's prescription uses Scrophulariaceae and Arctium lappa as the royal medicines. The combination of burdock and scrophulariaceae is a royal medicine. Pediculus, Malingen, and Pinellia are all ministerial drugs. Magnolia officinalis combined with perilla stalk, Trigonellae combined with Curcuma zedoaria, Shegan combined with wood butterfly, this prescription is Sasuke's medicine. Trigonellae combined with Curcuma zedoaria is used to treat blood. The medicine from blood is used to treat blood, and the medicine from qi is used to treat qi. Trachelospermia and Poria are also used as adjuvant medicines, and platycodon and licorice are used as envoy medicines. The above-mentioned raw materials are combined with a specific ratio to make the configuration reasonable and balanced. Each raw material works synergistically to treat both the root cause and the root cause. It can disseminate the lungs and regulate qi, resolve phlegm and relieve cough, warm the middle and relieve the throat, and has no toxic or side effects. It has good curative effect in the treatment of chronic pharyngitis. It has many advantages such as fast, strong efficacy, and low recurrence rate. It can effectively solve the problem of treatment and medication for chronic pharyngitis.

The invention provides a preparation method of a traditional Chinese medicine composition for treating chronic pharyngitis, which includes the following steps:

Mix Scrophulariaceae, Platycodon, Pediculus, Maltroot, Licorice, Pinellia, Trachelospermia, Magnolia officinalis, Perilla stalk, Arctium lappa, Trigonella, Curcuma, Shegan, Poria and Wood butterfly, heat for the first time Decoct and filter to obtain the first medicinal liquid. Decoct again and combine the medicinal liquids to get it.

The present invention is based on the weight portion of the above-mentioned Scrophulariaceae, Platycodon, Pediculus, Malinda root, Licorice, Pinellia pinellia, Trachelospermia, Magnolia officinalis, Perilla stalk, Arctium lappa, Trigonella striata, Curcuma, Shegan, Poria and Wood butterfly. The above has been clearly defined and will not be repeated here.

Take the above-mentioned traditional Chinese medicine components in parts by weight, add an appropriate amount of water and boil for 1 to 1.5 hours, filter, and obtain the first medicinal liquid; add an appropriate amount of water to the filter residue, continue to decoct for 30 to 40 minutes, and filter to obtain the second medicinal liquid. , the two medicinal solutions can be combined.

According to the present invention, the said Scrophulariaceae, Platycodon, Pediculus, Malinda root, licorice, Pinellia ternata, Trachelospermia, Magnolia officinalis, Perilla stalk, Arctium lappa, Trigonellae, Curcuma, Shegan, Poria and Wood butterfly. The mass ratio of the total to water is (1): (5).

The present invention provides the use of any of the above-mentioned traditional Chinese medicine compositions in preparing products for treating chronic pharyngitis.

The chronic pharyngitis of the present invention is chronic pharyngitis well known to those skilled in the art.

The invention provides a product for treating chronic pharyngitis, including the traditional Chinese medicine composition described in any one of the above technical solutions.

Preferably, the dosage form of the product is decoction, tablet, capsule, granule or pill.

The traditional Chinese medicine composition of the present invention can be prepared into specific traditional Chinese medicine preparations such as decoctions, tablets, capsules, granules or dropping pills using conventional preparation methods in pharmacy. When preparing these dosage forms, pharmaceutically acceptable excipients may be added according to actual needs, including but not limited to fillers, emulsifiers, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, and preservatives. agents and substrates, etc.

The invention provides a traditional Chinese medicine composition for treating chronic pharyngitis, including the following raw materials in parts by mass: 10 to 30 parts of Scrophulariaceae, 5 to 15 parts of Platycodon, 8 to 10 parts of Pediculus, 8 to 10 parts of Malinda root, and licorice. 8 to 10 parts, Pinellia 8 to 10 parts, Trachelospermia 10 to 20 parts, Magnolia officinalis 5 to 9 parts, Perilla stems 8 to 10 parts, Burdock 8 to 10 parts, Trichosanthes 10 to 20 parts, 10 to 20 parts of Zedoary, 5 to 9 parts of Shegan, 8 to 10 parts of Poria, and 3 to 6 parts of Wood Butterfly. The present invention has a synergistic effect through the compatibility of the above-mentioned components and proportions. The above-mentioned pharmaceutical compositions and dosage proportions of the present invention are interrelated to form an organic whole. The traditional Chinese medicine composition for treating chronic pharyngitis has the advantages of simple formula, quick effect, and high medicinal value. Technical effect with strong efficacy and no toxic side effects.

In order to further illustrate the present invention, a traditional Chinese medicine composition for treating chronic pharyngitis provided by the present invention, its preparation method and application are described in detail below with reference to the examples.

Example 1:

In the specific implementation of the present invention, the traditional Chinese medicine composition of the present invention is made of the following traditional Chinese medicines: 10 parts by weight of Scrophulariaceae, 5 parts of Platycodon, 8 parts of Pediculus, 8 parts of Malinda root, 8 parts of licorice, and 8 parts of Pinellia ternata. , 10 parts of Trachelospermia vine, 5 parts of Magnolia officinalis, 8 parts of Perilla stems, 8 parts of Arctium lappa, 10 parts of Trigonella trigonatum, 10 parts of Curcuma zedoary, 5 parts of Shegan, 8 parts of Poria, and 3 parts of Wood butterfly.

Example 2:

In the specific implementation of the present invention, the traditional Chinese medicine composition of the present invention is made of the following traditional Chinese medicines: 20 parts by weight of Scrophulariaceae, 10 parts of Platycodon, 9 parts of Pediculus, 9 parts of Malinda root, 9 parts of licorice, and 9 parts of Pinellia ternata. , Trachelospermia 15 parts, Magnolia officinalis 6 parts, Perilla stalk 9 parts, Burdock 9 parts, Trigonella 15 parts, Curcuma zedoary 15 parts, Shegan 6 parts, Poria cocos 9 parts, Wood butterfly 5 parts.

Example 3:

In the specific implementation of the present invention, the traditional Chinese medicine composition of the present invention is made of the following traditional Chinese medicines: 30 parts by weight of Scrophulariaceae, 15 parts of Platycodon, 10 parts of Pediculus, 10 parts of Malinda root, 10 parts of licorice, and 10 parts of Pinellia ternata. , 20 parts Trachelospermia vine, 9 parts Magnolia officinalis, 10 parts Perilla stems, 10 parts Arctium lappa, 20 parts Trigonella trigonatum, 20 parts Curcuma zedoary, 9 parts Shegan, 10 parts Poria, and 6 parts Wood butterfly.

The traditional Chinese medicine formed by the effective compatibility of the above-mentioned drugs is effective in treating chronic pharyngitis, and has been proven by clinical trials. Preferred Embodiment 2 of the present invention: The traditional Chinese medicine composition is made of the following traditional Chinese medicines: 20 parts by weight of Scrophulariaceae, 10 parts of Platycodon, 9 parts of Pediculus, 9 parts of Malinda root, 9 parts of Licorice, and 9 parts of Pinellia ternata. 15 parts of Trachelospermia vine, 6 parts of Magnolia officinalis, 9 parts of Perilla stalk, 9 parts of Arctium lappa, 15 parts of Trigonella trigonatum, 15 parts of Curcuma zedoary, 6 parts of Shegan, 9 parts of Poria, and 5 parts of Wood butterfly.

Comparative example 1:

Excluding the king medicine burdock, the traditional Chinese medicine composition is made of the following traditional Chinese medicines: 20 parts by weight of Scrophulariaceae, 10 parts of Platycodon, 9 parts of Pediculus, 9 parts of Horsetail root, 9 parts of licorice, 9 parts of Pinellia ternata, Trachelospermum. 15 parts of rattan, 6 parts of Magnolia officinalis, 9 parts of Perilla stalks, 15 parts of Trigonella striata, 15 parts of Curcuma zedoary, 6 parts of Shegan, 9 parts of Poria, and 5 parts of Wood butterfly.

Comparative example 2:

Use bamboo root instead of pinellia, 20 parts of Scrophulariaceae, 10 parts of Platycodon, 9 parts of Pediculus, 9 parts of Malinda root, 9 parts of licorice, 9 parts of Bamboo root, 15 parts of Trachelospermia, 6 parts of Magnolia officinalis, 9 parts of Purple Root. 9 parts of Su Geng, 9 parts of Arctium lappa, 15 parts of Trigonella, 15 parts of Zedoary, 6 parts of Shegan, 9 parts of Poria, and 5 parts of Wood Butterfly.

Comparative example 3:

Change the drug ratio, 9 parts Scrophulariaceae, 4 parts Platycodon, 7 parts Pediculus, 7 parts Malinda root, 7 parts Licorice, 7 parts Pinellia, 9 parts Trachelospermia, 4 parts Magnolia officinalis, 7 parts Perilla stems There are 7 parts of burdock, 9 parts of Trigonella, 9 parts of Curcuma, 4 parts of Shegan, 7 parts of Poria, and 2 parts of Wood Butterfly.

Preparation:

Take the above-mentioned traditional Chinese medicine components in parts by weight, add an appropriate amount of water and boil for 1-1.5 hours, filter to get the first medicinal solution; add an appropriate amount of water to the filter residue, continue to decoct for 30-40 minutes, filter and obtain the second medicinal solution. , the two medicinal solutions can be combined.

Example 4 Toxicity Test

Toxicity test

Select 20 adult female and male mice of similar weight and divide them into a control group and a drug administration group. The feeding conditions are the same. The control group is not fed drugs, and the drug group is fed drugs once a day. The physical condition of each mouse is recorded every day. , food intake, drinking water, and body weight. The test lasted for six months. Compared with the control group, the physical condition, food intake, drinking water, and weight gain of the mice in the administration group were all normal, and no mice were sick or died. It is suggested that the medicinal powder is safe and has no toxic or side effects.

Safety assessment

Monitor the patient's adverse reactions during the medication process. If serious adverse reactions of grade three or above occur, the medication process will be terminated immediately.

After observation, 100 patients did not experience serious adverse events during the administration period, and the incidence of grade 3 adverse reactions in each group was 0. The statistical results are shown in the table below.

Table 1 Safety evaluation

Example 2 Typical cases

Case 1: Yan Moumou, female, 56 years old, teacher. He went to the respiratory department outpatient clinic of our hospital on November 11, 2019. His main complaint was: repeated dry throat and itchy throat, which worsened for 5 days in half a year. History of current illness: The patient has had repeated dry throat and itchy throat in the past six months, which are often aggravated by external infection or excessive use of the throat. Five days ago, he developed dry throat and itchy throat due to external wind evil, accompanied by cough, expectoration, white sputum, and nausea. , dry and hard stool. Physical examination: The pharyngeal mucosa is congested, dark red, and thick, with white secretions attached. Red tongue, yellow and greasy coating, rapid pulse. The patient self-administered Western medicine cephalosporins, but the effect was not obvious. Western medicine diagnosis: chronic pharyngitis; Chinese medicine diagnosis: chronic laryngitis (phlegm-heat accumulation type); treatment principle: clearing away heat and detoxifying, resolving phlegm and soothing the throat. Instructions for use: Decoction in water, take 1 dose orally each time, three times a day, 20 days as a course of treatment. After 4 consecutive courses of treatment, the patient is cured and the patient reports that the symptoms have disappeared. There was no recurrence after six months of follow-up.

Case 2: Li Moumou, male, 32 years old. He went to the respiratory department outpatient clinic of our hospital in December 2019 with the main complaint of recurring pharyngeal discomfort for more than a year. History of current illness: Itchy throat, follicles on the posterior wall of the pharynx, red and swollen side walls, accompanied by cough, recent cold, no chills or fever, no headache, dizziness and other discomforts, dry stool, normal urine, red tongue with yellow and sticky coating, tip of the tongue The patient had red edges and a slippery and stringy pulse. He denied other medical history, and denied any history of drug or food allergies. He was diagnosed with chronic pharyngitis. Antibiotics were used repeatedly, but the effect was not obvious. Western medicine diagnosis: chronic pharyngitis; Chinese medicine diagnosis: chronic laryngitis (phlegm-heat accumulation type); treatment principle: clearing away heat and detoxifying, resolving phlegm and soothing the throat. How to take: Decoction in water, take 1 dose orally each time, three times a day, 20 days as a course of treatment. After taking 3 consecutive courses, observe symptoms such as throat, itching, follicles on the posterior pharyngeal wall, redness and swelling of the side wall, cough and other symptoms. disappear. There was no recurrence after six months of follow-up.

Case 3: Ren Moumou, female, 66 years old. In April 2019, he went to the respiratory department outpatient clinic of our hospital with the main complaint: recurring itchy and sore throat for more than a year, accompanied by cough and phlegm, yellow and sticky phlegm, and throat redness and swelling. History of current illness: Dark red congestion in the pharyngeal mucosa, aggravated by a recent cold and spicy food, poor sleep, difficulty falling asleep at night, no headache, dizziness or other discomforts, normal bowel movements, red tongue, yellow coating, and red tip of the tongue. She had a slippery and rapid pulse, and was in good health in the past. She denied other medical history, and denied any history of drug or food allergies. Due to repeated symptoms of acute pharyngitis, she was treated with antibiotics intravenously in the emergency outpatient department of our hospital many times, but the effect was not good. Western medicine diagnosis: chronic pharyngitis; Chinese medicine diagnosis: chronic laryngitis (phlegm-heat accumulation type); treatment principle: clearing away heat and detoxifying, resolving phlegm and soothing the throat. How to take: Decoction in water, take 1 dose orally each time, three times a day, 20 days as a course of treatment. After taking 4 consecutive courses, observe symptoms such as throat, itching, follicles on the posterior pharyngeal wall, redness and swelling of the side wall, cough and other symptoms. were significantly reduced. There was no recurrence after six months of follow-up.

The present invention will be further elaborated below in conjunction with the clinical trials conducted by our hospital, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine:

1. Case selection: The selected cases were all patients with chronic pharyngitis in our hospital. 100 patients with chronic pharyngitis were selected, 36 males and 64 females; the duration of the disease was 30 days to 2 years; 44 cases were chronic simple pharyngitis and chronic hypertrophic pharyngitis. 35 cases, 21 cases of chronic sicca pharyngitis,

2. Diagnostic criteria: According to the National Administration of Traditional Chinese Medicine, TCM disease and syndrome diagnosis and efficacy standards, the diagnosis is based on the patient's medical history, symptoms, and signs.

3. Treatment method: Take it every day according to the taking method of the present invention, take one dose orally each time, three times a day, 20 days as a course of treatment, a total of 3 to 5 courses of treatment, until the clinical symptoms and signs disappear, and then take to consolidate the curative effect. 2 courses of treatment and a follow-up visit every 3 months. During the treatment, the patient was instructed to refrain from smoking and drinking, avoid eating spicy and irritating foods, pay attention to voice fatigue, and stop using various lozenges.

4. Efficacy evaluation criteria:

Cure: Pharyngeal symptoms disappear, examination is normal, hyperplasia of lymphoid tissue on the throat wall disappears, and there is no swelling of the lateral pharyngeal cords. During the 6-month follow-up, the patient's condition was stable without recurrence.

Improvement: Pharyngeal symptoms and signs are significantly reduced, and the proliferation of lymphoid tissue on the throat wall is reduced. During the 3-month follow-up, the patient's condition was stable without recurrence.

Not healed: There is no obvious change in symptoms and signs.

5. Curative effect observation indicators:

Total score of symptoms and signs: Based on the main symptom score sheet, the patient's common symptoms, such as dry throat, itchy throat, sore throat, foreign body sensation in the throat, dry cough with phlegm, congestion of the pharyngeal mucosa, dry mucosa, less fluid, and lymphoid follicle hyperplasia, are evaluated. Observe and inquire, and record in detail. The total score is the sum of the patient's symptoms and signs. The higher the score, the more serious the symptoms and signs.

6. Therapeutic effect: 100 patients with chronic pharyngitis were treated with the present invention for 3 to 5 courses in clinical practice. After the clinical symptoms and signs disappeared, the curative effect was consolidated and taken for 2 courses. The therapeutic effect was evaluated using the efficacy evaluation standards: 78 cases were cured. , accounting for about 78%; 19 cases improved, accounting for about 19%; 3 cases did not recover, accounting for about 3%. The overall effectiveness is approximately 97%. The treatment effects are shown in Table 2 and Table 3.

6.1 Comparison of clinical efficacy

As shown in Table 2, the clinical effective rates of Examples 1-3 of the invention are 90%, 97%, and 92%, which are higher than those of the comparative group.

Table 2 Comparison of clinical efficacy of each group after treatment

6.2 Comparison of total scores of symptoms and signs

As shown in Table 3, compared with those before treatment and the Examples and Comparative Examples, Examples 1-3 of the invention can reduce the total score of symptoms and signs, and the difference is statistically significant.

Table 3 Comparison of the total scores of symptoms and signs in each group before and after treatment

Note: *After treatment, compared with the example group, P＜0.05, #After treatment, compared with the control group, P＜0.05.

7. Safety evaluation: Through follow-up visits, the inventor found that during the medication period, no patients who took the preparations of the embodiments of the present application had any side effects such as dry mouth, dizziness, headache, skin itching, diarrhea, etc., and only one patient had such side effects. There was slight nausea, and no other patients had any obvious nausea. When tracking and investigating the recurrence of patients one year after stopping the drug, it was found that none of the patients who took the preparations of the embodiments of the present invention had recurring episodes of chronic pharyngitis within one year. The statistical results are shown in Table 4. To sum up, the preparation of the present invention has quick effect, strong medicinal effect, is not easy to relapse, and has no toxic or side effects.

Table 4 Number of side effects occurring during medication and recurrence within one year after discontinuation of medication

Note: Recurrence rate = (number of people who relapse)/(total number of people)х100%

The above are only preferred embodiments of the present invention. It should be noted that those skilled in the art can make several improvements and modifications without departing from the principles of the present invention. These improvements and modifications can also be made. should be regarded as the protection scope of the present invention.

Claims (7)

1. A traditional Chinese medicine composition for treating chronic pharyngitis, which is characterized in that it consists of the following raw materials in parts by mass: 20 parts of Scrophulariaceae, 10 parts of Platycodon, 9 parts of Pediculus, 9 parts of Malinda root, 9 parts of Licorice, 9 parts of Pinellia ternata, 15 parts of Trachelospermia, 6 parts of Magnolia officinalis, 9 parts of Perilla stems, 9 parts of Arctium lappa. There are 15 parts of Trigonella striata, 15 parts of Curcuma zedoaria, 6 parts of Shegan, 9 parts of Poria cocos and 5 parts of Wood butterfly. 2. A preparation method of a traditional Chinese medicine composition for treating chronic pharyngitis according to claim 1, characterized in that it includes the following steps: Mix Scrophulariaceae, Platycodon, Pediculus, Maltroot, Licorice, Pinellia, Trachelospermia, Magnolia officinalis, Perilla stalk, Arctium lappa, Trigonella, Curcuma, Shegan, Poria and Wood butterfly, heat for the first time Decoct and filter to obtain the first medicinal liquid. Decoct again and combine the medicinal liquids to get it. 3. The preparation method according to claim 2, characterized in that the Scrophulariaceae, Platycodon, Pediculus, Malinda root, Licorice, Pinellia ternata, Trachelospermia, Magnolia officinalis, Perilla stalk, Arctium lappa, The mass ratio of the sum of Trigonella, Curcuma, Shegan, Poria and Wood Butterfly to water is 1:5. 4. The preparation method according to claim 2, characterized in that the first decoction time is 1 to 1.5 hours; the second decoction time is 30 to 40 minutes. 5. Application of the traditional Chinese medicine composition according to claim 1 in the preparation of products for treating chronic pharyngitis. 6. A product for treating chronic pharyngitis, characterized by comprising the traditional Chinese medicine composition according to claim 1. 7. The product according to claim 6, characterized in that the dosage form of the product is decoction, tablet, capsule, granule or pill.