CN106924378B - Chinese herbal medicine lipstick for preventing and/or treating chronic cheilitis - Google Patents

Abstract

The invention relates to a Chinese herbal lip balm for preventing and/or treating chronic cheilitis. The Chinese herbal lip balm is prepared by the following method: (1) taking 1.5 parts of beeswax and 2.0 parts of vaseline, heating and melting in a water bath to obtain a mixed solution 1 (2) Take 1.0 parts of lanolin and 5.0 parts of Chinese medicine extract, heat and melt in a water bath to obtain mixed solution 2; (3) mix mixed solution 1 and mixed solution 2, add 0.5 part of azone and mix well, place 50- Add peppermint essential oil at 60°C, mix and pack. The invention combines traditional Chinese medicine and daily skin care products, combines theory with practice, and derives a new type of Chinese herbal lip balm with therapeutic effect. It has high market promotion and application value.

Description

A Chinese herbal lip balm for preventing and/or treating chronic cheilitis

technical field

The invention relates to the technical field of traditional Chinese medicines, in particular to a Chinese herbal lip balm for preventing and/or treating chronic cheilitis.

Background technique

Chronic cheilitis is a chronic disease with the main clinical manifestations of redness, swelling, erosion, crusting, chapping, and gray scales on the lips. In recent years, the clinical prevalence has been increasing year by year. According to statistics, in 2010, about 0.21% of patients in the United States suffered from this disease. In 2013, the prevalence of chronic cheilitis in France reached 0.35%. As of 2014, there were 4,800 patients in China. About 10,000 patients suffer from chronic cheilitis. It can be seen that this disease has had a great impact on human health. How to find effective treatment measures for this disease has great clinical research significance and market value. Because the etiology and pathogenesis of chronic cheilitis is still unclear, there is no definite and effective targeted treatment drugs. Western medicine mainly uses antibiotics, hormone drugs, supplemented by vitamins and other daily nursing care. Although these methods can achieve certain results, they are all It cannot be cured, and it can truly relieve the suffering of patients. The course of chronic cheilitis is lingering, the symptoms are easy to recur, and the patient suffers from extreme pain. Therefore, patients have extremely high demands for the development of practical and effective pure natural protective products.

"The Yellow Emperor's Classic of Internal Medicine" has a cloud: "The spleen opens its orifices in the mouth, and its beauty is in the lips", "The lips are the official of the spleen." As early as the Ming Dynasty, our country recognized in the "Surgical Authenticity: Lip Wind": "Lip wind, Yang Ming's stomach fire attack, the lower lip is itchy, swollen, ruptured and watery, and it is difficult to heal without pain." The disease is due to the accumulation of heat in the spleen and stomach, re-sensation of exogenous pathogens, wind and heat fighting each other, smoked on the lips, and the lips are red and itchy. When the wind prevails, it is exposed, and when the heat prevails, it becomes dry, so it is seen that the lips are cracked, dry and painful. It can be seen that the spleen and stomach are closely related to the pathogenesis of lip wind. Therefore, in the treatment, while dispelling external pathogens, it should also take care of the spleen and stomach, and treat both inside and outside. External therapy is a characteristic therapy of TCM surgery. Compared with the internal treatment method that regulates the internal organs and six fu-organs, the external treatment method is more targeted and more effective because it directly acts on the skin lesions of the affected area. In different stages of the disease, different therapeutic dosage forms are used, and different Chinese herbal medicines are used in combination and application of syndrome differentiation and treatment. With the change of the disease, the drug can be selected flexibly and dynamically, and it has strong pertinence for the treatment of the disease.

Lip balm has become one of the essential skin care products in the daily life of modern people. It has a huge market size in the mass market at home and abroad, in various regions, in various age groups, in various occupations, and at various levels of consumption. As the public's demand for lip balm gradually increases steadily, major brand merchants are also doing more and more research on the product composition, characteristics and efficacy of lip balm, hoping to meet the different needs of the public and create a larger market platform. At present, the lip balms available on the market at home and abroad only have basic functions such as moisturizing, moisturizing, and sun protection, and are suitable for the public who are prone to dry and chapped lips. For those who have been plagued by lip balm for a long time, these ordinary lip balms cannot provide protection. Therefore, a new type of lip balm that is convenient and easy to carry and has a therapeutic effect is urgently needed to relieve the lip skin lesions of lip balm patients. Traditional Chinese medicine is a complementary and alternative therapy that has received more and more attention at home and abroad, and the results are satisfactory. The present invention adds Chinese herbal medicine elements into traditional lip balm, and selects corresponding traditional Chinese medicines and preparations for targeted treatment according to the disease characteristics of chronic cheilitis. It embodies the characteristics of syndrome differentiation and treatment of traditional Chinese medicine. It can not only effectively treat patients with chronic cheilitis, but also prevent the recurrence of cheilitis, so that the lingering and difficult course of the disease can be controlled, and it can truly solve the difficult clinical problems. The invention combines Chinese herbal medicine with daily skin care products, combines theory with practice, and derives a new type of lip balm with both preventive and therapeutic effects, which has high popularization and application value.

SUMMARY OF THE INVENTION

The first object of the present invention is to provide a traditional Chinese medicine extract for preventing and/or treating chronic cheilitis in view of the deficiencies in the prior art.

The second object of the present invention is to provide the use of the above-mentioned traditional Chinese medicine extract in view of the deficiencies in the prior art.

The third object of the present invention is to provide a Chinese herbal lip balm for preventing and/or treating chronic cheilitis in view of the deficiencies in the prior art.

For realizing above-mentioned first purpose, the technical scheme that the present invention takes is:

A traditional Chinese medicine extract for preventing and/or treating chronic cheilitis, the medicinal active ingredient of the traditional Chinese medicine extract is extracted from the following raw materials by weight: 35-45 parts of comfrey, 15-25 parts of madder, raw licorice 15-25 servings.

Further, the active components of the traditional Chinese medicine extract are extracted from the following raw materials by weight: 38-42 parts of comfrey, 18-22 parts of madder, and 18-22 parts of raw licorice.

Further, the active components of the traditional Chinese medicine extract are extracted from the following raw materials by weight: 40 parts of comfrey, 20 parts of madder, and 20 parts of raw licorice.

Further, the preparation method of the traditional Chinese medicine extract is as follows: take the bulk drug according to the weight portion described in claim 1, add 30 times of boiling water for 2h for the first time, and add 20 times of boiling water for 2h for the second time, Filter, combine the filtrates, and concentrate the filtrate into a traditional Chinese medicine extract with a density of 1.05-1.10 g/cm ³ at 60°C.

For realizing the above-mentioned second purpose, the technical scheme that the present invention takes is:

The application of any one of the above Chinese medicine extracts in the preparation of medicines for preventing and/or treating chronic cheilitis.

Further, the medicine also includes pharmaceutically acceptable excipients, including but not limited to: mannitol, sorbitol, sodium metabisulfite, sodium bisulfite, sodium thiosulfate, cysteine hydrochloride, Thioglycolic acid, methionine, vitamin C, disodium EDTA, calcium sodium EDTA, monovalent alkali metal carbonate, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, chlorine Potassium, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon derivatives, cellulose and its derivatives, alginate, gelatin, polyethylene Pyrrolidone, Glycerin, Tween 80, Agar, Calcium Carbonate, Calcium Bicarbonate, Surfactant, Polyethylene Glycol, Cyclodextrin, β-Cyclodextrin, Phospholipids, Kaolin, Talc, Calcium Stearate, Magnesium stearate, paraffin, petrolatum.

Further, the chronic cheilitis is chronic chapped cheilitis.

For realizing the above-mentioned third purpose, the technical scheme that the present invention takes is:

A Chinese herbal lip balm for preventing and/or treating chronic cheilitis, the Chinese herbal lip balm is prepared by the following method:

(1) take by weighing 1.5 parts of beeswax, 2.0 parts of vaseline, heat and melt in a water bath to obtain mixed solution 1;

(2) take by weighing 1.0 parts of lanolin, 5.0 parts of Chinese herbal extracts as described in any one above, and heat and melt in a water bath to obtain mixed solution 2;

(3) Mix mixed solution 1 and mixed solution 2, add 0.5 part of azone and mix evenly, place at 50-60°C, add peppermint essential oil, mix and pack.

Further, the addition amount of the peppermint essential oil is 0.1-50 parts.

Further, the chronic cheilitis is chronic chapped cheilitis.

The advantages of the present invention are:

1. The Chinese herbal lip balm of the present invention has few flavors, easy-to-obtain raw materials, simple preparation process, and low cost, has remarkable effect on chronic cheilitis, and is not easy to relapse after being cured.

2. In the Chinese herbal lip balm of the present invention, the madder and comfrey have a significant synergistic effect, greatly improving the therapeutic effect of the Chinese herbal medicine on inflammation, and the curative effect is more significant.

3. In the Chinese herbal lip balm of the present invention, the proportion of the Chinese medicine raw materials is obtained through a large number of experimental screening, and has the advantages of good curative effect and remarkable effect.

Detailed ways

The present invention will be further described below in conjunction with specific embodiments. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that those skilled in the art can make various changes or modifications to the present invention after reading the contents described in the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

Embodiment 1 Chinese medicine composition (1) for preventing or treating chronic cheilitis

Weigh the raw materials according to parts by weight: 40 parts of comfrey, 20 parts of madder, and 20 parts of raw licorice.

The traditional Chinese medicine composition (two) of embodiment 2 prevention or treatment of chronic cheilitis

Weigh the raw materials according to parts by weight: 35 parts of comfrey, 15 parts of madder, and 15 parts of raw licorice.

The traditional Chinese medicine composition (three) of embodiment 3 prevention or treatment of chronic cheilitis

Weigh the raw materials according to parts by weight: 45 parts of comfrey, 25 parts of madder, and 25 parts of raw licorice.

The traditional Chinese medicine composition (four) of embodiment 4 prevention or treatment of chronic cheilitis

The raw materials were weighed in parts by weight: 45 parts of comfrey, 25 parts of madder, and 15 parts of raw licorice.

The traditional Chinese medicine composition (5) of embodiment 5 prevention or treatment of chronic cheilitis

Weigh the raw materials according to parts by weight: 45 parts of comfrey, 15 parts of madder, and 15 parts of raw licorice.

The traditional Chinese medicine composition (six) of embodiment 6 prevention or treatment of chronic cheilitis

Weigh the raw materials according to parts by weight: 38 parts of comfrey, 18 parts of madder, and 18 parts of raw licorice.

The traditional Chinese medicine composition (seven) of embodiment 7 prevention or treatment of chronic cheilitis

The raw materials were weighed in parts by weight: 42 parts of comfrey, 18 parts of madder, and 18 parts of raw licorice.

Embodiment 8 Chinese medicine composition (eight) for preventing or treating chronic cheilitis

The raw materials were weighed in parts by weight: 42 parts of comfrey, 22 parts of madder, and 18 parts of raw licorice.

Embodiment 9 Chinese medicine composition (nine) for preventing or treating chronic cheilitis

Weigh the raw materials according to parts by weight: 42 parts of comfrey, 22 parts of madder, and 22 parts of raw licorice.

Embodiment 10 The preparation of Chinese medicine extract for preventing or treating chronic cheilitis (1)

Weigh the traditional Chinese medicine raw materials according to the weight parts described in Example 1, add 30 times of boiling water for 2 hours for the first time, add 20 times of boiling water for 2 hours for the second time, filter, and combine the filtrate, and the filtrate is in the environment of 60 ° C. It is concentrated into a traditional Chinese medicine extract with a density of 1.05-1.10 g/cm ³ .

Embodiment 11 The preparation of Chinese medicine extract for preventing or treating chronic cheilitis (two)

Weigh the traditional Chinese medicine raw materials according to the weight parts described in Example 2, add 30 times of boiling water for 2 hours for the first time, add 20 times of boiling water for 2 hours for the second time, filter, combine the filtrates, and the filtrate is heated at 60 ℃. It is concentrated into a traditional Chinese medicine extract with a density of 1.05-1.10 g/cm ³ .

Embodiment 12 The preparation of Chinese medicine extract for preventing or treating chronic cheilitis (three)

Weigh the traditional Chinese medicine raw materials according to the weight parts described in Example 3, add 30 times of boiling water for 2 hours for the first time, add 20 times of boiling water for 2 hours for the second time, filter, combine the filtrates, and the filtrate is heated at 60 ° C. It is concentrated into a traditional Chinese medicine extract with a density of 1.05-1.10 g/cm ³ .

Embodiment 13 The preparation of Chinese herbal balm for preventing or treating chronic cheilitis (1)

(1) take by weighing 1.5 parts of beeswax, 2.0 parts of vaseline, heat and melt in a water bath to obtain mixed solution 1;

(2) Weigh 1.0 parts of lanolin and 5.0 parts of Chinese medicine extract prepared in Example 10, heat and melt in a water bath to obtain mixed solution 2;

(3) Mix the mixed solution 1 and the mixed solution 2, add 0.5 part of azone and mix evenly, place it at 50-60° C. and add 10 parts of peppermint essential oil, and then canning after mixing.

Embodiment 14 The preparation of Chinese herbal balm for preventing or treating chronic cheilitis (two)

(1) take by weighing 1.5 parts of beeswax, 2.0 parts of vaseline, heat and melt in a water bath to obtain mixed solution 1;

(2) Weigh 1.0 parts of lanolin and 5.0 parts of the Chinese medicine extract prepared in Example 11, heat and melt in a water bath to obtain mixed solution 2;

(3) Mix the mixed solution 1 and the mixed solution 2, add 0.5 part of azone and mix evenly, place it at 50-60° C. and add 10 parts of peppermint essential oil, and then canning after mixing.

The preparation of embodiment 15 prevention or treatment of chronic cheilitis Chinese herbal balm (three)

(1) take by weighing 1.5 parts of beeswax, 2.0 parts of vaseline, heat and melt in a water bath to obtain mixed solution 1;

(2) Weigh 1.0 parts of lanolin and 5.0 parts of Chinese medicine extract prepared in Example 12, heat and melt in a water bath to obtain mixed solution 2;

(3) Mix the mixed solution 1 and the mixed solution 2, add 0.5 part of azone and mix evenly, place it at 50-60° C. and add 10 parts of peppermint essential oil, and then canning after mixing.

Example 16

(1) Weigh raw materials according to parts by weight: 30 parts of comfrey, 30 parts of madder, 30 parts of raw licorice; add 30 times of boiling water for 2h for the first time, add 20 times of boiling water for 2h for the second time, filter, The filtrate was combined, and the filtrate was concentrated into a traditional Chinese medicine extract with a density of 1.05-1.10 g/cm ³ under the environment of 60 °C;

(2) take by weighing 1.5 parts of beeswax and 2.0 parts of vaseline, heat and melt in a water bath to obtain mixed solution 1;

(3) take by weighing 1.0 parts of lanolin and 5.0 parts of traditional Chinese medicine extracts, heat and melt in a water bath to obtain mixed solution 2;

(4) Mix the mixed solution 1 and the mixed solution 2, add 0.5 part of azone and mix evenly, place it at 50-60° C. and add 10 parts of peppermint essential oil, and pack it in a can after mixing.

Example 17

(1) Weigh raw materials according to parts by weight: 50 parts of comfrey, 10 parts of madder, 10 parts of raw licorice; add 30 times of boiling water for 2h for the first time, add 20 times of boiling water for 2h for the second time, filter, The filtrate was combined, and the filtrate was concentrated into a traditional Chinese medicine extract with a density of 1.05-1.10 g/cm ³ under the environment of 60 °C;

(2) take by weighing 1.5 parts of beeswax and 2.0 parts of vaseline, heat and melt in a water bath to obtain mixed solution 1;

(3) take by weighing 1.0 parts of lanolin and 5.0 parts of traditional Chinese medicine extracts, heat and melt in a water bath to obtain mixed solution 2;

(4) Mix the mixed solution 1 and the mixed solution 2, add 0.5 part of azone and mix evenly, place it at 50-60° C. and add 10 parts of peppermint essential oil, and pack it in a can after mixing.

Example 18 Animal test for treating chronic cheilitis

A total of 50 Kunming mice, half female, were randomly divided into 5 groups with 10 mice in each group. Apply xylene 0.03mL/mouse to the right ear of the mice. After 0.5 h of inflammation, an equal amount of the Chinese herbal lip balm of the present invention was evenly applied to the inflammation site of the right ear of the mice respectively. After 4 hours, the mice were sacrificed by cervical dislocation, the left and right auricles were cut off, and the drug remaining in the right auricle was removed, and the left and right ears of the mice were punched with a punch. The ear swelling rate was calculated by weighing with an analytical balance. Ear swelling rate=(weight of right ear piece-weight of left ear piece)/weight of left ear piece×100%. The statistical results are shown in the table below.

test group n (only) ear swelling rate Example 13 10 44.85±21.60 Example 14 10 65.40±35.55 Example 15 10 62.60±32.25 Example 16 10 93.95±39.65 Example 17 10 96.45±38.80

The above results show that, in the mouse group coated with the same dose of Chinese herbal lip balm, the ear swelling rate of Example 13, Example 14, and Example 15 is lower than that of the experimental groups of Example 16 and Example 17, indicating the Chinese herbal medicine of the present invention. Lip balm can significantly reduce and subside the inflammation caused by xylene. In-group comparison, the ear swelling rate of the drug group of Example 13 was significantly lower than that of Example 14 and Example 15 (P<0.05), which indicated that Example 13 (ie, 40 parts of comfrey, 20 parts of madder, and 20 parts of raw licorice) ) is the best combination.

Example 19 Clinical experiment for treating chronic cheilitis

1 case

A total of 180 patients with chronic nonspecific cheilitis who were treated in Yueyang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from October 2014 to July 2016 were selected, including 83 males and 97 females, aged 12-55 years, with an average age of 23.55 years.

1.1 Diagnostic criteria

Chronic chapped cheilitis: The lip mucosa is slightly swollen, dry and shrunken, with a few thin white scabs, and the mucosa lacks elasticity. There may be 2-3 chapped cracks that can penetrate deep into the mucosa and cause bleeding and form blood scabs.

1.2 Inclusion criteria

Meet the diagnostic criteria and have not received relevant treatment within 1 month before the visit. Patients were informed and voluntarily enrolled in the clinical study.

1.3 Exclusion criteria

(1) Women who are pregnant, planning to become pregnant or breastfeeding;

(2) Complicated with severe cardiovascular and cerebrovascular, liver, kidney and hematopoietic system diseases, moderate or above diabetes mellitus, and osteoporosis;

(3) Patients with mental illness;

(4) Patients with poor compliance, refusal by subjects, and patients who are considered unsuitable to participate in clinical trials by investigators.

1.4 Rejection Criteria

(1) Patients who do not cooperate, do not take medication on time, or use other methods to treat themselves during the study;

(2) Those who have serious adverse reactions and cannot continue treatment;

(3) Those who need to take other drugs during treatment, which may interfere with the research results.

2 treatment methods

2.1 Oral education: quit bad habits such as licking and biting lips; drink more water, eat more fruits and vegetables, avoid hot, spicy and spicy food, quit smoking and alcohol; do not use cosmetics indiscriminately; in cold, dry and windy environments Wear a mask when in the middle; avoid sun exposure.

2.2 Drug therapy

The patients were divided into 6 groups on average, which were control group, treatment group 1, treatment group 2, treatment group 3, treatment group 4, treatment group 5. The 6 groups were compared in pairs, in terms of gender, age, course of disease and clinical manifestations. There was no significant difference in other aspects (P>0.05), which was comparable.

Control group: Oral 21 Jinweita multi-dimensional element tablets, 1 tablet each time, 2 times a day, 1 week as a course of treatment, and the curative effect will be determined after four courses of treatment.

Treatment group 1: The Chinese herbal lip balm of Example 13 was given, and 2-4 g of the lip balm was evenly applied to the affected part of the lips every day, once in the morning and once in the evening, and the curative effect was judged after 2 months of treatment.

Treatment group 2: The Chinese herbal lip balm of Example 14 was given, and 2-4 g of the lip balm was evenly applied to the affected part of the lips every day, once in the morning and once in the evening, and the curative effect was determined after 2 months of treatment.

Treatment group 3: The Chinese herbal lip balm of Example 15 was given, and 2-4 g of the lip balm was evenly applied to the affected part of the lips every day, once in the morning and once in the evening, and the curative effect was judged after 2 months of treatment.

Treatment group 4: The Chinese herbal lip balm of Example 16 was given, and 2-4 g of the lip balm was evenly applied to the affected part of the lips every day, once in the morning and once in the evening, and the curative effect was determined after 2 months of treatment.

Treatment group 5: The Chinese herbal lip balm of Example 17 was given, and 2-4 g of the lip balm was evenly applied to the affected part of the lips every day, once in the morning and once in the evening, and the curative effect was judged after 2 months of treatment.

3 Efficacy criteria

3.1 Observation Metrics and Scoring

Objectively record the subjective symptoms and signs of patients before treatment, at the end of treatment, and at 3 months, 6 months, 9 months, and 12 months after treatment, and divide them into 0, 1, 2 according to mild, moderate, and severe. , Level 3.

(1) According to the patient's autonomous feeling, it is divided into: 0 is no itching and dryness, 1 is slightly dry and occasional itching and discomfort, 2 is paroxysmal itching or pain, obvious dryness, 3 is severe dryness, persistent Restricted opening due to itching.

(2) Hyperemia/swelling: 0 means none, 1 means involving 1/3 of the vermilion, 2 means involving 2/3 of the vermilion, and 3 means involving the entire vermilion.

(3) desquamation/scrubbing: 0 is none, 1 is a small amount of desquamation or a small amount of scabbing, 2 is obvious desquamation, scabbing and involves the entire vermilion, 3 is severe desquamation, blood scabbing and involving the mouth week skin.

(4) Chapped: 0 is no, 1 is a little dry, no obvious cracks are seen, 2 is obviously dry and longitudinal cracks appear when moving, 3 is obvious cracks with a little bleeding.

(5) Erosion: 0 for none, 1 for erosion surface less than 2 mm, 2 for erosion surface larger than 2 mm and less than half lip, 3 for large erosion of upper or lower lip, and 4 for large erosion of both lips.

(6) Skin around the lips: 0 is none, 1 is slightly dry and desquamated, 2 is large-scale desquamation with small cracks, and the skin is flushed, and 3 is the skin with obvious cracks, skin flushing, crusting, and pigmentation.

3.2 Criteria for clinical diagnosis, cure and improvement:

With reference to the "Clinical Disease Diagnosis Based on Cure and Improvement Criteria", the efficacy evaluation criteria:

Efficacy index=(score before treatment-score after treatment)/score before treatment*100%.

Recovery: The vermilion mucosa returned to normal, and the curative effect index was 95% to 100%;

Significantly effective: The symptoms and signs of vermilion are significantly relieved, and the curative effect index is 61% to 95%;

Improvement: the symptoms and signs of the vermilion area were slightly reduced, and the efficacy index was 20% to 60%;

Invalid: the symptoms and signs of vermilion are not relieved or aggravated, and the curative effect index is less than 20%;

The recovery and marked effects are summed up, and the effective rate is calculated = (number of recoveries + number of marked effects)/total number.

4 results

The results of follow-up at the end of treatment and after the end of treatment are shown in the following table.

group effective rate after treatment Effective in the 3rd month 6th month effective 9th month effective 12th month effective control group 73.3% (22/30) 70.00% (21/30) 53.3% (16/30) 53.3% (16/30) 53.3% (16/30) treatment group one 96.7% (29/30) 96.7% (29/30) 96.7% (29/30) 96.7% (29/30) 96.7% (29/30) Treatment group two 83.3% (25/30) 80.0% (24/30) 80.0% (24/30) 80.0% (24/30) 80.0% (24/30) Treatment group three 86.6% (26/30) 83.3% (25/30) 83.3% (25/30) 83.3% (25/30) 83.3% (25/30) Treatment group four 66.7% (20/30) 66.7% (20/30) 50.0% (15/30) 50.0% (15/30) 50.0% (15/30) Treatment group five 63.3% (19/30) 63.3% (19/30) 53.3% (16/30) 53.3% (16/30) 53.3% (16/30)

It can be seen from the above results that the Chinese herbal lip balm of the present invention has a good curative effect on chronic cheilitis. Compared with the control group, the therapeutic effect of the Chinese herbal lip balm of the present invention is significantly improved in treatment group 1, treatment group 2 and treatment group 3; Compared with the treatment group 4 and treatment group 5, the therapeutic effect of the treatment group 1, treatment group 2 and treatment group 3 was significantly improved; within the group comparison, the curative effect of treatment group 1 was significantly higher than that of treatment group 2 and treatment group 3, and The long-term efficacy (months 3-12) of treatment group 1 was also significantly better than that of other treatment groups, indicating that the composition of Example 13 (ie, 40 parts of comfrey, 20 parts of madder, and 20 parts of raw licorice) was the best combination.

The above are only the preferred embodiments of the present invention. It should be pointed out that for those skilled in the art, without departing from the method of the present invention, several improvements and supplements can be made, and these improvements and supplements should also be regarded as It is the protection scope of the present invention.

Claims (4)

1. a Chinese herbal balm for the treatment of chronic chapped cheilitis, is characterized in that, described Chinese herbal lip balm is prepared by the following method: (1) Weigh 1.5 parts of beeswax and 2.0 parts of vaseline, heat and melt in a water bath to obtain mixed solution 1; (2) Weigh 1.0 parts of lanolin and 5.0 parts of traditional Chinese medicine extracts, heat and melt in a water bath to obtain mixed solution 2; (3) Mix mixture 1 and mixture 2, add 0.5 part of azone and mix well, place at 50-60°C, add peppermint essential oil, mix and pack; The preparation method of the traditional Chinese medicine extract is as follows: take raw materials: 35-45 parts of comfrey, 15-25 parts of madder, 15-25 parts of raw licorice, add 30 times of boiling water for 2 hours for the first time, and add 30 times of boiling water for 2 hours for the second time. Extracted with 20 times of boiling water for 2 hours, filtered, combined the filtrate, and concentrated the filtrate into a traditional Chinese medicine extract with a density of 1.05-1.10 g/cm ³ at 60°C. 2. Chinese herbal lip balm according to claim 1, is characterized in that, the add-on of described peppermint essential oil is 0.1-50 part. 3. Chinese herbal lip balm according to claim 1, is characterized in that, the active ingredient of described Chinese medicine extract is extracted by the raw material medicine of following parts by weight: 38-42 parts of comfrey, 18-22 parts of madder, raw licorice 18-22 servings. 4. Chinese herbal lip balm according to claim 1, is characterized in that, the active ingredient of described Chinese medicine extract is extracted by the following raw material medicines in parts by weight: 40 parts of comfrey, 20 parts of madder, 20 parts of raw licorice.