CN114791502B - Sample detection method and sample analyzer - Google Patents
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Abstract
The application discloses a sample detection method and a sample analyzer. The sample detection method comprises the following steps: responding to a sample detection instruction based on a first detection mode, and performing detection on the blood sample to obtain a first detection result; switching the sample analyzer from a first detection mode to a second detection mode in response to a received switching instruction, and determining whether the sample analyzer needs to execute a first cleaning process based on a first detection result, wherein the first cleaning process at least comprises a process of cleaning a part of the device components and the pipelines which are shared when the second detection mode executes detection and the first detection mode executes detection; and under the condition that the sample analyzer does not need to execute the first cleaning process, responding to a sample detection instruction based on the second detection mode, and detecting the body fluid sample to obtain a second detection result. According to the embodiment, the detection speed of the body fluid detection can be improved while the accuracy of the body fluid detection is ensured.
Description
Technical Field
The present application relates to the field of medical detection and analysis technologies, and in particular, to a sample detection method and a sample analyzer.
Background
The sample analyzer comprises a blood cell analyzer, the blood cell analyzer is one of the sample analyzers commonly used for medical detection, and is an instrument for detecting parameters such as the number, the proportion and the like of blood cells (red blood cells, white blood cells and blood platelets) in blood, and the functions of microbial infection type, anemia diagnosis and treatment, blood disease diagnosis and the like of a detected sample are realized through the analysis of the blood. With the progress of technology and the development of science and technology, the function of the blood cell analyzer is continuously expanded, the performance is continuously improved, the automation degree is continuously improved, and the blood cell analyzer is widely applied clinically. Blood cell analyzers can also be used to measure cells in body fluids.
When a sample analyzer detects a blood sample and a body fluid sample, the sample analyzer generally needs to react with a reaction reagent in a reaction cell, and after the test is completed, part of reactants remain in the reaction cell. The residual reactant accumulated in the reaction tank to a certain amount affects the accuracy of the subsequent measurement value, so the residual reactant needs to be cleaned.
Common cleaning methods include cleaning of the instrument components and tubing used in the testing process after each test and periodic cleaning at intervals. Cleaning and regular cleaning after each detection have a certain cleaning effect, but the current requirement on the detection speed of the instrument is still difficult to meet.
Disclosure of Invention
In order to solve the problem that a sample analyzer in the prior art is difficult to meet the requirement on the detection speed of the analyzer, the application provides the sample analyzer and the sample detection method.
In order to solve the above problem, an embodiment of the present application provides a sample detection method, which is applied to a sample analyzer having a first detection mode and a second detection mode, wherein the first detection mode is used for detecting a blood sample, and the second detection mode is used for detecting a body fluid sample, and the body fluid sample is different from the blood sample, and the sample detection method includes: responding to a sample detection instruction based on the first detection mode, and performing detection on the blood sample to obtain a first detection result; switching the sample analyzer from the first detection mode to the second detection mode in response to a received switching instruction, and determining whether the sample analyzer needs to perform a first cleaning flow based on the first detection result, wherein the first cleaning flow at least comprises a flow for cleaning a part of parts and pipelines which are shared when detection is performed in the second detection mode and detection is performed in the first detection mode; and under the condition that the sample analyzer does not need to execute a first cleaning process, responding to a sample detection instruction based on the second detection mode, and detecting the body fluid sample to obtain a second detection result.
In an embodiment, after performing the test on the blood sample and obtaining the first test result, the method further includes: after the first detection result is obtained, a second cleaning process is performed on the device part and/or the pipeline through which the blood sample flows, wherein the cleaning grade of the second cleaning process is lower than the cleaning grade corresponding to the first cleaning process.
In one embodiment, the determining whether the sample analyzer needs to perform a first wash procedure based on the first detection result includes: obtaining a blood cell test result from the first test result; comparing the blood cell detection result with a first comparison threshold; determining that the sample analyzer executes the first cleaning process if the blood cell detection result is greater than or equal to the first comparison threshold; determining that the sample analyzer does not need to perform the first wash procedure if the blood cell detection result is less than the first comparison threshold.
In an embodiment, the determining that the sample analyzer does not need to perform the first washing procedure if the blood cell detection result is less than the first comparison threshold includes: comparing the blood cell detection result with the second comparison threshold value if the blood cell detection result is less than the first comparison threshold value; wherein the first comparison threshold is greater than the second comparison threshold; performing background detection in the second detection mode to obtain a background detection result under the condition that the blood cell detection result is greater than the second comparison threshold value; and determining that the sample analyzer does not need to execute the first cleaning process under the condition that the background detection result is qualified.
In an embodiment, after performing the background detection in the second detection mode to obtain a background detection result, the method includes: executing the first cleaning process under the condition that the background detection result is unqualified; and returning to the step: and performing background detection in the second detection mode to obtain a background detection result.
In an embodiment, in the case that the blood cell detection result is greater than or equal to the first comparison threshold, after determining that the sample analyzer performs the first washing procedure, the method includes: executing the first cleaning process; performing background detection in the second detection mode to obtain a background detection result; determining whether the first cleaning process needs to be executed again based on the background detection result; and under the condition that the background detection result is unqualified, returning to the step: executing the first cleaning process; and determining that the sample analyzer does not need to execute the first cleaning process under the condition that the background detection result is qualified.
In one embodiment, the obtaining the blood cell test result from the first test result includes: obtaining a white blood cell detection result and a red blood cell detection result from the first detection result; the comparing the blood cell detection result with a first comparison threshold comprises: comparing the leukocyte detection result with a third comparison threshold; comparing the red blood cell detection result with a fourth comparison threshold; determining that the sample analyzer executes the first washing procedure if the blood cell detection result is greater than or equal to the first comparison threshold, including: determining that the sample analyzer executes the first washing procedure when the white blood cell detection result is greater than or equal to the third comparison threshold and/or the red blood cell detection result is greater than or equal to the fourth comparison threshold.
In an embodiment, the detecting the body fluid sample in response to the sample detection instruction based on the second detection mode without executing the first washing procedure by the sample analyzer to obtain a second detection result includes: responding to an operation instruction of a user, and performing background detection in the second detection mode to obtain a background detection result; determining whether the first cleaning process needs to be executed based on the background detection result; and detecting the body fluid sample to obtain a second detection result under the condition that the background detection result is qualified.
In one embodiment, the determining whether the sample analyzer needs to perform a first wash procedure based on the first detection result includes: acquiring the detection times of the blood sample in the first detection mode, wherein the detection times are the times of detecting the blood sample in the first detection mode after a cleaning process is executed; and determining whether the sample analyzer needs to execute a cleaning process based on the first detection result and the detection times.
In order to solve the above problems, embodiments of the present application provide a sample analyzer having a first detection mode for detecting a blood sample and a second detection mode for detecting a body fluid sample, wherein the body fluid sample is different from the blood sample, and the sample analyzer is configured to perform the above sample detection method.
Compared with the prior art, the sample detection method comprises the following steps: responding to a sample detection instruction based on a first detection mode, and performing detection on the blood sample to obtain a first detection result; switching the sample analyzer from a first detection mode to a second detection mode in response to a received switching instruction, and determining whether the sample analyzer needs to execute a first cleaning process based on a first detection result, wherein the first cleaning process at least comprises a process of cleaning a part of the device components and the pipelines which are shared when the second detection mode executes detection and the first detection mode executes detection; and under the condition that the sample analyzer does not need to execute the first cleaning process, responding to a sample detection instruction based on the second detection mode, and detecting the body fluid sample to obtain a second detection result. Through the embodiment, compared with the situation that the blood sample is detected and before body fluid is detected, the body fluid detection device directly enters the cleaning process, the first cleaning process does not need to be immediately entered, whether the first cleaning process needs to be executed or not is judged by analyzing the first detection result, and when the first cleaning process does not need to be executed, the body fluid sample can be directly entered into the detection process, so that the body fluid detection accuracy is ensured, and meanwhile, the detection speed of body fluid detection of the device can be improved.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the application.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required in the embodiments will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic flow chart of one embodiment of a sample detection method provided herein;
FIG. 2 is a schematic flow chart illustrating one embodiment of determining whether a first cleaning process is required for a sample analyzer based on a first test result;
FIG. 3 is a flowchart illustrating an embodiment of step S204 shown in FIG. 2;
FIG. 4 is a flowchart illustrating an embodiment after step S204 shown in FIG. 2;
fig. 5 is a schematic flow chart illustrating another embodiment of determining whether the sample analyzer needs to perform the first washing process based on the first detection result.
Detailed Description
The present application will be described in further detail with reference to the following drawings and examples. It is to be noted that the following examples are only illustrative of the present application, and do not limit the scope of the present application. Likewise, the following examples are only some examples and not all examples of the present application, and all other examples obtained by a person of ordinary skill in the art without any inventive step are within the scope of the present application.
Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments. It is explicitly and implicitly understood by one skilled in the art that the embodiments described herein can be combined with other embodiments.
Throughout the description of the present application, it is intended that the terms "mounted," "disposed," "connected," and "connected" be construed broadly and encompass, for example, fixed connections, removable connections, or integral connections unless expressly stated or limited otherwise; can be mechanically connected or electrically connected; they may be directly connected or may be connected via an intermediate medium. To one of ordinary skill in the art, the foregoing may be combined in any suitable manner with the specific meaning ascribed to the present application.
The application provides a sample detection method, which is applied to a sample analyzer, the sample analyzer is applied to the field of medical or biochemical analysis and is used for detecting a sample, and a relatively common sample analyzer can be a blood cell analyzer; the sample analyzer may also be other non-blood-ball clinical laboratory equipment. The present application provides a sample analyzer having a first detection mode and a second detection mode. In a first test mode, the sample analyzer may be used to test a blood sample, and in a second test mode, the sample analyzer may be used to test a bodily fluid sample, wherein the bodily fluid sample is different from the blood sample.
Blood sample testing may include blood routine testing and specific protein testing. Blood routine tests include, but are not limited to, WBC (White Blood Cell) tests, HGB (Hemoglobin) tests, RBC tests, DIFF (DIFFerential, five White Cell classification) tests, or RET (reticulocyte) tests. The specific protein includes one of SAA (serum amyloid A protein), CRP (C-reactive protein), TRF (transferrin), hs-CRP (hypersensitive C-reactive protein), PCT (procalcitonin ) and D-Dimer (D-Dimer).
Body fluid refers to bodily fluids present within a body cavity. In particular, the body fluid may include: CSF (cerebrospinal-spinal fluid, fluid filling the ventricles of the brain and subarachnoid space), PE (Pleural Effusion ), ascites (peritoneal Effusion), pericardial fluid (pericardial Effusion), synovial fluid (synovial fluid: fluid present in the joints, synovial capsule, and tendon sheath), and the like. For example, the blood cell analyzer is a blood routine, SAA, CRP and body fluid combined-examination machine.
Referring to fig. 1, fig. 1 is a schematic flow chart of an embodiment of a sample detection method provided in the present application. Specifically, the method includes the following steps S101 to S103.
Step S101: in response to a sample detection instruction based on the first detection mode, detection is performed on the blood sample, and a first detection result is obtained.
The sample analyzer can comprise a first detection mode and a second detection mode, and when a specific item needs to be detected, the sample analyzer can obtain a corresponding sample detection instruction so as to realize switching between the first detection mode and the second detection mode. For example, the sample analyzer may provide a visual display panel to the user, and the user may touch the corresponding control button on the display panel to make the sample analyzer receive the corresponding sample detection instruction; or the master control module in the sample analyzer can be connected with mobile terminals such as a mobile phone or a tablet personal computer through communication modes such as Bluetooth, WIFI and NFC, and sample detection instructions sent by the mobile terminals such as the mobile phone and the tablet personal computer are received.
After receiving a sample detection instruction based on the first detection mode, the sample analyzer starts to perform a detection operation on the blood sample to obtain a first detection result. In particular, the sample analyzer of the present application may include a sample collection module, a reagent supply module, a reaction module, and a sample detection module.
The sample collection module is used for collecting and providing a sample to be detected. Specifically, before blood sample detection, blood at a specific part of a patient can be collected through the blood collection tube, the test tube rack on which the collection tube is placed is further placed in the sample analyzer, and when detection is needed, the sample collection module can further collect the blood in the blood collection tube, and further provide the collected blood to the reaction module under the control of a certain means. It should be noted that, in general, the blood sample used in the blood test is not directly tested by using blood extracted from a patient, but the collected blood needs to be processed by a certain means, such as dilution, incubation, dissolution, etc., according to the test item to be tested, so as to obtain the blood sample for testing.
The reagent providing module is used for providing reagents used for analyzing blood. In this embodiment, a specific reagent is supplied from the reagent supply module and is transferred to the reaction module to process blood with the reagent. The reaction module is used for receiving the blood provided by the sample collection module and the reagent provided by the reagent providing module, and mixing and reacting the blood and the reagent to obtain a reacted blood sample. And then conveying the blood sample to a sample detection module, and performing detection operation on the blood sample by using the sample detection module to obtain a first detection result.
The sample collection module may be implemented by various means when providing blood to the reaction module, providing a reagent to the reaction module by the reagent providing module, and providing a blood sample to the sample detection module by the reaction module, for example, the sample collection module or the reagent providing module may be driven to a corresponding position and then release the blood or the reagent in the corresponding reaction module, or may be implemented by other means.
Step S102: and switching the sample analyzer from the first detection mode to the second detection mode in response to the received switching instruction, and determining whether the sample analyzer needs to execute the first cleaning process based on the first detection result. Wherein the first cleaning flow includes at least a flow of performing cleaning of a part of the device parts and the piping which are common when the detection is performed in the second detection mode and the detection is performed in the first detection mode.
The acquisition operation of the switching instruction comprises the following steps: the sample analyzer provides a visual display panel for a user, and the user touches a corresponding control button on the display panel to enable the sample analyzer to receive a corresponding switching instruction; or the master control module in the sample analyzer can be connected with a mobile terminal such as a mobile phone or a tablet personal computer through communication modes such as Bluetooth, WIFI and NFC, and switching instructions sent by the mobile phone or the tablet personal computer are received. After receiving the switching instruction, the sample analyzer can be switched from the first detection mode to the second detection mode to complete the initial operation of the body fluid detection process.
After the blood sample testing operation is performed in the first testing mode, it is necessary to collect a body fluid from the patient in some specific cases to perform the body fluid testing operation using the collected body fluid to obtain a body fluid sample. In some feasible schemes, the body fluid test item and the blood test item respectively perform test operations by using different sample analyzers, but in this way, the economic cost is undoubtedly high; in the present embodiment, the sample analyzer includes both a first detection mode for detecting a blood sample and a second detection mode for detecting a sample of a body fluid. In an embodiment, the sample testing in the first testing mode and the sample testing in the second testing mode may share at least a portion of the sample analyzer components and tubing. Compared with a sample analyzer which is respectively used for detecting by two instruments, the sample analyzer in the embodiment can reduce the use cost.
However, since almost no cells are present in body fluids, when a tumor or an injury is present in a diseased or related organ, blood cells, abnormal cells, bacteria and the like may be contained. Such as cerebrospinal fluid, the following clinical inferences can be made from the analysis: for example, subarachnoid hemorrhage may be if red blood cells are increased, meningitis may be suspected if neutrophils are increased, infectious diseases (parasites and fungi) may be suspected if eosinophils are increased, tuberculous and viral meningitis may be suspected if monocytes are increased, and metastasis of the tumor to the medulla membrane may be suspected if other cells are increased. In the case of ascites and pleural fluid, if nucleated cells such as mesothelial cells, macrophages and tumor cells are contained in addition to blood cells, they can be used as an index for diseases such as cancer, and these indices can be obtained by analyzing nucleated cells other than blood cells.
Therefore, before the body fluid is detected, in order to show the accuracy of the body fluid detection result, the cleanness of a part through which the body fluid flows needs to be kept, and for a sample analyzer which can be used for detecting a blood sample and a body fluid sample at the same time, after the blood sample is detected, the problem of influence of the blood detection on the body fluid detection result can be further reduced by directly executing a cleaning process. However, after the blood test, the cleaning process before the body fluid test takes a lot of time, and the way of directly starting the cleaning process is undoubtedly not good in practicability for the case that the body fluid test result needs to be quickly obtained in emergency treatment and the like.
With the continuous improvement of sample analyzers, the part through which the blood sample flows can greatly reduce the possibility of being adhered by the blood sample in the process of detecting the blood sample, and when the content of certain substances in the blood sample is low, the detection result of the body fluid sample cannot be influenced even if a cleaning process is not required to be performed before the body fluid detection. In this embodiment, the first detection result includes relevant parameters corresponding to the detection result of the blood sample, and the first detection result may be analyzed from the parameters of the detection result of the blood sample to determine whether the first cleaning process needs to be performed before the body fluid detection is performed, and the first cleaning process is performed only when the first cleaning process needs to be performed, and the body fluid detection is directly performed without performing the first cleaning process, so that the sample detection efficiency of the apparatus may be greatly improved without affecting the test result under specific conditions.
Also, the first cleaning flow includes at least a flow of performing cleaning of a part of the device parts and the piping which are common when the detection is performed in the second detection mode and the detection is performed in the first detection mode. That is, when the first cleaning process is performed, only the parts and the piping in the sample analyzer that are common to both the blood test and the body fluid test can be cleaned, and the cleaning efficiency can be improved even when the first cleaning process needs to be performed.
Step S103: and under the condition that the sample analyzer does not need to execute the first cleaning process, responding to a sample detection instruction based on the second detection mode, and detecting the body fluid sample to obtain a second detection result.
In this embodiment, under the condition that the sample analyzer obtains the first detection result without executing the first cleaning process, the body fluid sample can be directly detected in response to the sample detection instruction based on the second detection mode, and the second detection result including the body fluid detection result is obtained. The obtaining manner of the sample detection instruction based on the second detection mode may be the same as the obtaining manner of the sample detection instruction based on the first detection mode, and is not described herein again.
Through above-mentioned embodiment, for after blood sample detection, directly get into before the body fluid detects and wash the flow, this scheme need not to get into first washing flow immediately, but judges whether need carry out first washing flow through the first testing result of analysis, when need not to carry out first washing flow, can directly get into the detection flow of body fluid sample to can also improve the instrument and carry out the sample detection speed that the body fluid detected when guaranteeing the body fluid detection accuracy.
In an embodiment, after performing the test on the blood sample to obtain the first test result, the method further comprises: after the first detection result is obtained, a second cleaning process is performed on the device component and/or the pipeline through which the blood sample flows, wherein the cleaning grade of the second cleaning process is lower than that of the first cleaning process. In this embodiment, after the blood sample is obtained, there may be a short period of inactivity of the sample analyzer, such as an idle period during which a body fluid sample needs to be prepared, during which a second cleaning procedure may be performed on the device component and/or tubing through which the blood sample flows. The cleaning grade of the second cleaning process is lower than the cleaning grade corresponding to the first cleaning process, namely the cleaning time required by the second cleaning process is shorter than the cleaning time required by the first cleaning process, when the blood sample is detected, the body fluid sample is required to be detected, and the instrument parts and/or pipelines through which the blood sample flows are rapidly and pertinently cleaned by using the second cleaning process, so that the accuracy of a body fluid detection result can be further improved on the basis of not consuming the body fluid detection time.
Referring to fig. 2, fig. 2 is a schematic flow chart illustrating an embodiment of determining whether the sample analyzer needs to perform the first washing process based on the first detection result. Specifically, the method includes the following steps S201 to S204.
Step S201: and obtaining a blood cell detection result from the first detection result.
Blood cells, also called "blood cells", are cells present in the blood and can be distributed throughout the body along with the flow of blood. In mammals, blood cells are mainly three types, red blood cells, white blood cells, and platelets. The primary function of red blood cells is to transport oxygen. Leukocytes play a major role in immunity. When germs invade the human body, white blood cells can penetrate through the capillary wall and concentrate to the invaded part of the germs to be phagocytized after being surrounded by the germs. Platelets play an important role in the process of hemostasis. Blood cells account for approximately 45% of the blood volume and include red blood cells, white blood cells, and platelets.
Step S202: the blood cell detection result is compared to a first comparison threshold.
The first comparison threshold may be a value obtained through trial and error. By comparing the parameter in the blood cell detection result with the first comparison threshold, a comparison result in which the blood cell detection result is equal to or greater than the first comparison threshold, or a comparison result in which the blood cell detection result is smaller than the first comparison threshold can be obtained.
Step S203: and determining that the sample analyzer executes the first cleaning process when the blood cell detection result is greater than or equal to the first comparison threshold.
Under the condition that the blood cell detection result is greater than or equal to the first comparison threshold, the content of blood cells in the blood sample is high, and it can be judged that the blood sample is more likely to pollute a component through which the blood sample flows in the sample analyzer when the sample analyzer detects the blood sample.
Step S204: in the case where the blood cell detection result is less than the first comparison threshold, it is determined that the sample analyzer does not need to perform the first washing procedure.
Under the condition that the blood cell detection result is smaller than the first comparison threshold, the content of blood cells in the blood sample is low, at the moment, it can be judged that when the sample analyzer detects the blood sample, the blood sample has high possibility of not polluting a part through which the blood sample in the sample analyzer flows, at the moment, the sample analyzer is directly used for detecting the body fluid sample, and the accuracy of body fluid sample detection is still not influenced. In order to ensure the efficiency of the body fluid sample detection, the sample analyzer can be controlled to directly perform the body fluid sample detection process without performing the first cleaning process.
In one embodiment, the step of obtaining the blood cell test result from the first test result (step S201) includes: and obtaining a white blood cell detection result and a red blood cell detection result from the first detection result. The step of comparing the blood cell detection result with a first comparison threshold (step S202) includes: comparing the white blood cell detection result with a third comparison threshold and the red blood cell detection result with a fourth comparison threshold. And a step (S203) of determining that the sample analyzer executes the first washing process when the blood cell detection result is equal to or greater than the first comparison threshold, the method including: and determining that the sample analyzer executes the first cleaning process under the condition that the white blood cell detection result is greater than or equal to the third comparison threshold value and/or the red blood cell detection result is greater than or equal to the fourth comparison threshold value.
Since the volume and the number of the white blood cells and the red blood cells are much larger than those of the platelets in the blood sample, when the sample analyzer performs the blood sample detection and detects the white blood cell detection result and the red blood cell detection result, the comparison between the blood cell detection and the first comparison threshold is divided into the comparison between the white blood cell detection result and the third comparison threshold and the comparison between the red blood cell detection result and the fourth comparison threshold, so that whether the sample analyzer needs to perform the first cleaning process before performing the body fluid detection can be more accurately judged. Wherein the third comparison threshold and the fourth comparison threshold may be the same or different in magnitude.
In other embodiments, the blood cell detection result further includes a platelet detection result, and the comparison of the blood cell detection with the first comparison threshold may be further divided into a comparison of a white blood cell detection result with a third comparison threshold, a comparison of a red blood cell detection result with a fourth comparison threshold, and a comparison of a platelet detection result with a fifth comparison threshold, wherein the third comparison threshold, the fourth comparison threshold, and the fifth comparison threshold may be the same or different in magnitude. It is further possible to accurately determine whether the first washing process is required before the body fluid is detected by the sample analyzer.
Referring to fig. 3, fig. 3 is a flowchart illustrating an embodiment of step S204 shown in fig. 2. Specifically, the method includes the following steps S301 to S303.
Step S301: comparing the blood cell detection result with a second comparison threshold value in the case where the blood cell detection result is smaller than the first comparison threshold value; wherein the first comparison threshold is greater than the second comparison threshold.
When the blood cell detection result is smaller than the first comparison threshold, it indicates that the content of blood cells in the blood sample is low, and at this time, it can be determined that the blood sample is more likely to not contaminate a component through which the blood sample flows in the sample analyzer when the sample analyzer detects the blood sample. However, if the blood cell detection result is smaller than the first comparison threshold but very close to the first comparison threshold, it cannot be determined that the body fluid detection is performed without cleaning, and the accuracy of the body fluid detection is not affected. In this case, the blood cell detection result may be compared with the second comparison threshold by setting the second comparison threshold, and the first comparison threshold is larger than the second comparison threshold, to determine whether the blood cell detection result is between the first comparison threshold and the second comparison threshold.
Step S302: and under the condition that the blood cell detection result is greater than the second comparison threshold value, performing background detection in a second detection mode to obtain a background detection result.
And under the condition that the blood cell detection result is greater than the second comparison threshold value, namely the blood cell detection result is between the first comparison threshold value and the second comparison threshold value, background detection can be carried out in the second detection mode to obtain a background detection result.
Background detection refers to the measurement of a blank sample containing no cells instead of the sample. For example, the background measured is the wash solution. After background detection, if more cells are found in the detection result, the cells are considered to be remained in the sample analyzer, and the accuracy of sample detection is affected by sample detection at the moment. The method is not limited to the use of a washing solution as the background, and any liquid containing no components of the cells may be used as the background, and various liquids such as a diluent, water, and the like may be used.
Step S303: and under the condition that the background detection result is qualified, determining that the sample analyzer does not need to execute the first cleaning process.
And under the condition that the background detection is qualified, namely, more cells do not appear in the detection result of the background detection, the sample analyzer can be determined not to have enough impurities which influence the detection result, and the sample analyzer can be determined to directly carry out the body fluid detection process in the second detection mode without executing the first cleaning process.
Step S304: executing a first cleaning process under the condition that a background detection result is unqualified; and returning to the step: and carrying out background detection in a second detection mode to obtain a background detection result.
And under the condition that the background detection is unqualified, namely more cells appear in the detection result of the background detection, determining that impurities which can affect the detection result are remained in the sample analyzer, determining that the sample analyzer needs to execute the first cleaning process, returning to the step of carrying out the background detection again after the first cleaning process is executed, and repeating the steps to obtain the cleaned sample analyzer.
In the above embodiment, under the condition that the sample analyzer does not need to execute the first cleaning process, the blood cell detection result is compared with the second comparison threshold, and then whether the background detection is needed or not is automatically selected according to the comparison result. In other embodiments, background detection may also be performed by acquiring operating instructions prior to performing body fluid detection without the need for the sample analyzer to perform a first wash procedure. Specifically, step S103 includes: responding to an operation instruction of a user, and performing background detection in a second detection mode to obtain a background detection result; determining whether a first cleaning process needs to be executed based on a background detection result; and detecting the body fluid sample to obtain a second detection result under the condition that the background detection result is qualified.
And under the condition that the background detection is qualified, namely more cells do not appear in the detection result of the background detection, determining that impurities which are enough to influence the detection result do not remain in the sample analyzer, and determining that the sample analyzer does not need to execute a first cleaning process and directly performs a body fluid detection process in a second detection mode to obtain a second detection result. In this embodiment, whether to perform background detection is selected before performing body fluid detection in a semi-automatic manner, so that it can be further ensured that the result of body fluid detection is not affected by blood detection, and the accuracy of the detection result of body fluid detection output of the sample analyzer can be improved while the sample detection speed of the sample analyzer is satisfied. In other embodiments, the first cleaning process can be manually operated in a semi-automatic manner in case of a failure of the background detection, for example, by manually setting the cleaning level of the first cleaning process or setting the cleaning parameters, etc.
Referring to fig. 4, fig. 4 is a schematic flowchart of an embodiment after step S204 shown in fig. 2. Specifically, the method includes steps S401 to S403.
Step S401: a first cleaning process is performed.
Under the condition that the blood cell detection result is greater than or equal to the first comparison threshold, the content of blood cells in the blood sample is high, and it can be judged that the blood sample is more likely to pollute a component through which the blood sample flows in the sample analyzer when the sample analyzer detects the blood sample.
Step S402: and carrying out background detection in a second detection mode to obtain a background detection result.
After the first cleaning process is executed, background detection can be performed in the second detection mode to obtain a result of the background detection.
Step S403: it is determined whether the first cleaning process needs to be performed again based on the background detection result.
Determining whether the sample analyzer has been cleaned by the last performed first cleaning procedure based on the content of cells in the background detection result.
Step S404: and under the condition that the background detection result is unqualified, returning to the step: a first cleaning process is performed.
And under the condition that the background detection is unqualified, namely more cells appear in the detection result of the background detection, determining that impurities which are enough to influence the detection result remain in the sample analyzer, determining that the sample analyzer needs to execute the first cleaning process again, returning to the step of carrying out the background detection again after the first cleaning process is executed, and repeating the steps to obtain the cleaned sample analyzer.
Step S405: and under the condition that the background detection result is qualified, determining that the sample analyzer does not need to execute the first cleaning process.
And under the condition that the background detection is qualified, namely more cells do not appear in the detection result of the background detection, determining that impurities which can influence the detection result do not remain in the sample analyzer, and determining that the sample analyzer does not need to execute the first cleaning process and can directly carry out the body fluid detection process in the second detection mode.
Referring to fig. 5, fig. 5 is a schematic flow chart illustrating another embodiment of determining whether the sample analyzer needs to perform the first cleaning process based on the first detection result. Specifically, the method includes the following steps S501 to S502.
Step S501: and acquiring the detection times of the blood sample in the first detection mode, wherein the detection times are the times of detecting the blood sample in the first detection mode after the cleaning process is executed.
The sample analyzer is maintained in the first detection mode to detect a plurality of blood samples, and the first cleaning process and/or the second cleaning process need not be executed when the blood sample is detected within a preset number of times. When the number of blood sample tests reaches a certain number, the first cleaning procedure and/or the second cleaning procedure can be automatically or manually performed on the sample analyzer.
Step S502: and determining whether the sample analyzer needs to execute a cleaning process based on the first detection result and the detection times.
The priority of determining whether the sample analyzer needs to perform the washing process using the first detection result may be higher than the priority of determining whether the sample analyzer needs to perform the washing process using the first detection result. For example, when it is determined from the first detection result that the sample analyzer needs to perform the washing process, the first washing process and/or the second washing process may be directly entered without assisting in determining whether the sample analyzer needs to perform the washing process according to the number of detections. When it is determined from the first detection result that the sample analyzer does not need to perform the cleaning process, in order to improve accuracy of the body fluid detection, it may be assisted to determine whether the sample analyzer needs to perform the cleaning process according to the number of times of detection, and when the number of times of detection is greater than a preset number threshold, the cleaning process is performed.
In one embodiment, the step of determining whether the sample analyzer needs to perform the washing process based on the first detection result and the number of detections (step S502) includes: and under the condition that the sample analyzer is determined to need to execute the cleaning process, determining the cleaning degree of the cleaning process according to the detection times.
The cleaning intensity of the cleaning process may include: selection of the type and/or amount of cleaning fluid, number of cleanings, time of cleanings, intensity of cleanings, and the like. The intensity of the cleaning process can be increased along with the increase of the detection times, and when the detection times meet a specific gradient threshold, the cleaning intensity corresponding to the specific gradient threshold is selected. For example, the gradient threshold may include a first gradient threshold and a second gradient threshold, the number of detections corresponding to the first gradient threshold is less than the number of detections corresponding to the second gradient threshold, the kind of the wash solution of the first gradient threshold may include a buffer, and the kind of the wash solution of the second gradient threshold may include a buffer and a hemolytic agent; the volume, the washing times and the washing time of the washing liquid with the first gradient threshold are smaller than those of the washing liquid with the second gradient threshold, so that the washing strength can be selected according to actual conditions, for example, the washing strength is selected according to the detection times of the blood sample between body fluid detections, and the accuracy of subsequent body fluid sample detection is improved.
The application also provides a sample analyzer, which has a first detection mode and a second detection mode, wherein the first detection mode is used for detecting a blood sample, and the second detection mode is used for detecting a body fluid sample, wherein the body fluid sample is different from the blood sample, and the sample analyzer is used for the sample detection method of any one of the embodiments.
In addition, if the above functions are implemented in the form of software functions and sold or used as a standalone product, the functions may be stored in a storage medium readable by a mobile terminal, that is, the present application also provides a storage device storing program data, which can be executed to implement the method of the above embodiments, the storage device may be, for example, a usb disk, an optical disk, a server, etc. That is, the present application may be embodied as a software product, which includes several instructions for causing an intelligent terminal to perform all or part of the steps of the methods described in the embodiments.
In the description of the present application, reference to the description of the terms "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the present application. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of the present application, "plurality" means at least two, e.g., two, three, etc., unless specifically limited otherwise.
Any process or method descriptions in flow charts or otherwise described herein may be understood as representing modules, segments, or portions of code which include one or more executable instructions for implementing specific logical functions or steps in the process, and alternate implementations are included within the scope of the preferred embodiment of the present application in which functions may be executed out of order from that shown or discussed, including substantially concurrently or in reverse order, depending on the functionality involved, as would be understood by those reasonably skilled in the art of the present application.
The logic and/or steps represented in the flowcharts or otherwise described herein, such as an ordered listing of executable instructions that can be viewed as implementing logical functions, can be embodied in any computer-readable medium for use by or in connection with an instruction execution system, apparatus, or device (e.g., a personal computer, server, network device, or other system that can fetch the instructions from the instruction execution system, apparatus, or device and execute the instructions). For the purposes of this description, a "computer-readable medium" can be any means that can contain, store, communicate, propagate, or transport the program for use by or in connection with the instruction execution system, apparatus, or device. More specific examples (a non-exhaustive list) of the computer-readable medium would include the following: an electrical connection (electronic device) having one or more wires, a portable computer diskette (magnetic device), a Random Access Memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), an optical fiber device, and a portable compact disc read-only memory (CDROM). Additionally, the computer-readable medium could even be paper or another suitable medium upon which the program is printed, as the program can be electronically captured, via for instance optical scanning of the paper or other medium, then compiled, interpreted or otherwise processed in a suitable manner if necessary, and then stored in a computer memory.
The above description is only an embodiment of the present application, and is not intended to limit the scope of the present application, and all equivalent structures or equivalent processes performed by the present application and the contents of the attached drawings, which are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (9)
1. A method for testing a sample, the method being applied to a sample analyzer having a first testing mode for testing a blood sample and a second testing mode for testing a body fluid sample, wherein the body fluid sample is different from the blood sample, the method comprising:
responding to a sample detection instruction based on the first detection mode, and performing detection on the blood sample to obtain a first detection result;
switching the sample analyzer from the first detection mode to the second detection mode in response to a received switching instruction, and determining whether the sample analyzer needs to perform a first cleaning process based on the first detection result, wherein the first cleaning process at least includes a process of performing cleaning on a part of the unit parts and the pipelines that are common when the second detection mode performs detection and the first detection mode performs detection;
under the condition that the sample analyzer does not need to execute a first cleaning process, responding to a sample detection instruction based on the second detection mode, and detecting the body fluid sample to obtain a second detection result;
wherein the determining whether the sample analyzer needs to perform a first wash procedure based on the first detection result comprises:
acquiring the detection times of the blood sample in the first detection mode, wherein the detection times are the times of detecting the blood sample in the first detection mode after a cleaning process is executed;
determining whether the sample analyzer needs to execute a cleaning process based on the first detection result and the detection times;
the determining whether the sample analyzer needs to perform a washing process based on the first detection result and the detection times includes:
determining the cleaning degree of the cleaning process according to the detection times under the condition that the sample analyzer needs to execute the cleaning process, wherein the cleaning degree and the detection times both correspond to corresponding gradient thresholds, the cleaning degree at least comprises the types of cleaning liquids, the gradient thresholds comprise a first gradient threshold and a second gradient threshold, the detection times corresponding to the first gradient threshold are smaller than the detection times corresponding to the second gradient threshold, the types of the cleaning liquids corresponding to the first gradient threshold comprise buffer solutions, and the types of the cleaning liquids corresponding to the second gradient threshold comprise buffer solutions and hemolytic agents.
2. The method for testing a sample according to claim 1, wherein the testing the blood sample after obtaining the first test result further comprises:
after the first detection result is obtained, a second cleaning process is performed on the device part and/or the pipeline through which the blood sample flows, wherein the cleaning grade of the second cleaning process is lower than the cleaning grade corresponding to the first cleaning process.
3. The method of claim 1, wherein the determining whether the sample analyzer needs to perform a first washing procedure based on the first detection result comprises:
obtaining a blood cell test result from the first test result;
comparing the blood cell detection result with a first comparison threshold;
determining that the sample analyzer executes the first washing procedure if the blood cell detection result is greater than or equal to the first comparison threshold;
determining that the sample analyzer does not need to perform the first wash procedure if the blood cell detection result is less than the first comparison threshold.
4. The method according to claim 3, wherein the determining that the sample analyzer does not need to perform the first washing procedure if the blood cell detection result is less than the first comparison threshold comprises:
comparing the blood cell detection result with a second comparison threshold value if the blood cell detection result is less than the first comparison threshold value; wherein the first comparison threshold is greater than the second comparison threshold;
under the condition that the blood cell detection result is larger than the second comparison threshold value, performing background detection in the second detection mode to obtain a background detection result;
and determining that the sample analyzer does not need to execute the first cleaning process under the condition that the background detection result is qualified.
5. The method for detecting samples according to claim 4, wherein after performing background detection in the second detection mode to obtain a background detection result, the method comprises:
executing the first cleaning process under the condition that the background detection result is unqualified;
and returning to the step: and performing background detection in the second detection mode to obtain a background detection result.
6. The method according to claim 3, wherein the method includes, after determining that the sample analyzer performs the first washing process if the blood cell detection result is equal to or greater than the first comparison threshold value:
executing the first cleaning process;
performing background detection in the second detection mode to obtain a background detection result;
determining whether the first cleaning process needs to be executed again based on the background detection result;
and under the condition that the background detection result is unqualified, returning to the step: executing the first cleaning process;
and determining that the sample analyzer does not need to execute the first cleaning process under the condition that the background detection result is qualified.
7. The method for detecting a specimen according to claim 3,
the obtaining of the blood cell test result from the first test result comprises: obtaining a white blood cell detection result and a red blood cell detection result from the first detection result;
the comparing the blood cell detection result with a first comparison threshold comprises:
comparing the leukocyte detection result with a third comparison threshold;
comparing the red blood cell detection result with a fourth comparison threshold;
the determining that the sample analyzer executes the first washing procedure when the blood cell detection result is greater than or equal to the first comparison threshold includes:
determining that the sample analyzer executes the first washing procedure when the white blood cell detection result is greater than or equal to the third comparison threshold and/or the red blood cell detection result is greater than or equal to the fourth comparison threshold.
8. The method for testing a sample according to claim 1, wherein the testing the body fluid sample in response to the sample testing instruction based on the second testing mode without executing the first washing procedure to obtain the sample analyzer to obtain the second testing result comprises:
responding to an operation instruction of a user, and performing background detection in the second detection mode to obtain a background detection result;
determining whether the first cleaning process needs to be executed based on the background detection result;
and detecting the body fluid sample to obtain a second detection result under the condition that the background detection result is qualified.
9. A sample analyzer having a first detection mode for detecting a blood sample and a second detection mode for detecting a body fluid sample, wherein the body fluid sample is different from the blood sample, the sample analyzer being adapted to perform the sample detection method of any one of claims 1-8.
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