CN114344372B - Traditional Chinese medicine composition for treating primary liver cancer and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating primary liver cancer, which is prepared by decocting senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati in water, and has the obvious effects of quick response, good curative effect, small side effect and obvious inhibition effect on tumors.

Description

Traditional Chinese medicine composition for treating primary liver cancer and preparation method thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating primary liver cancer.

Technical Field

Primary liver cancer, abbreviated as liver cancer, usually occurs in hepatocytes or intrahepatic bile duct epithelial cells, which is one of the common malignant tumors in our country. Typical symptoms and signs of the liver cancer are usually in middle and late stages, and symptoms such as hypochondriac pain, hypodynamia, emaciation, jaundice, ascites and the like are mainly caused, on one hand, cancer pain accompanied by liver cancer is caused by that liver capsule is easily pulled to cause pain due to infiltration of liver cancer cells, and along with further development of cancer, adjacent blood vessels, peripheral nerves, lymphatic vessels, soft tissues and the like of the liver are sequentially invaded, pressed or stimulated by the liver cancer cells, so that the pain of the body and the mind is aggravated; at present, the three-step drug analgesic method recommended by WHO is generally adopted, and although pain can be relieved to a certain extent, adverse reactions caused by long-term use of the analgesic are large, so that the application process is also limited to different degrees.

In the latest diagnosis and treatment standard of primary liver cancer (2019 edition), the advantages of the traditional Chinese medicine, such as good curative effect and improvement of life quality, in the aspect of preventing and treating tumor diseases are pointed out, and the traditional Chinese medicine has become one of important means for treating liver cancer. On the basis, it is one direction of current research to find a traditional Chinese medicine composition which has the advantages of quick response, good curative effect, small side effect and obvious inhibition effect on tumors.

The invention comprises the following steps:

aiming at the defects of the prior art, the invention provides a traditional Chinese medicine composition for treating primary liver cancer, which has the obvious effects of quick response, good curative effect, small side effect and obvious inhibition effect on tumors.

The specific technical scheme of the invention is realized as follows:

a traditional Chinese medicine composition for treating primary liver cancer consists of the following components in parts by weight: 30-50 parts of senecio scandens, 20-40 parts of white snake grass, 10-30 parts of ground grass, 10-30 parts of Japanese ardisia herb, 10-30 parts of cortex albiziae, 10-30 parts of fevervine, 10-30 parts of radix bupleuri, 10-30 parts of dried orange peel and 20-40 parts of semen astragali complanati.

Preferably, the traditional Chinese medicine composition for treating primary liver cancer comprises the following components in parts by weight: 40-50 parts of senecio scandens, 30-40 parts of white snake grass, 20-30 parts of ground grass, 25-30 parts of Japanese ardisia herb, 10-15 parts of cortex albiziae, 10-20 parts of fevervine, 10-15 parts of radix bupleuri, 10-20 parts of dried orange peel and 20-30 parts of semen astragali complanati.

Preferably, the traditional Chinese medicine composition for treating primary liver cancer comprises the following components in parts by weight: 50 parts of senecio scandens, 40 parts of white snake grass, 30 parts of ground grass, 30 parts of Japanese ardisia herb, 10 parts of cortex albiziae, 10 parts of fevervine, 25 parts of radix bupleuri, 15 parts of dried orange peel and 20 parts of semen astragali complanati.

In the formulation, the composition may be in the form of a gel,

herba Senecionis Scandentis, bitter and cold; enter lung and liver meridians; clear away heat and toxic materials, improve eyesight, and promote diuresis. The main indications are: carbuncle, sore, cold, fever, conjunctival congestion, swelling and pain, diarrhea, dysentery and skin eczema.

White snake grass is cool in nature and slightly bitter and sweet in taste; enter stomach meridian, large intestine meridian and small intestine meridian. Clearing heat, promoting diuresis, removing toxic substances, and resisting cancer.

Di Yu Cao is cool in nature, sweet and slightly bitter in flavor. Enter liver meridian, gallbladder meridian and large intestine meridian. Clearing heat and promoting diuresis, removing toxic substance, removing blood stasis and detumescence, and relieving pain.

Herba Ardisiae Japonicae is neutral in nature, bitter and pungent in flavor. Enter lung meridian and liver meridian. Relieving cough, eliminating phlegm, promoting blood circulation, promoting urination, and removing toxic substances.

Albizzia bark, cortex Albizziae, has flat property and sweet taste. It enters heart meridian, liver meridian and lung meridian. Resolving stagnation, tranquillizing, promoting blood circulation and detumescence.

Paederia scandens is neutral in nature, sweet and bitter in taste. It enters spleen meridian, stomach meridian, liver meridian and lung meridian. Dispelling pathogenic wind, promoting blood circulation, relieving pain, removing toxic substance, resolving food stagnation, removing dampness, and relieving swelling.

Chai Hu is slightly cold in nature and bitter in taste. It enters liver meridian, gallbladder meridian and lung meridian. Relieving exterior and interior syndrome, soothing liver, and elevating yang.

Chen Pi is pungent in flavor, bitter in flavor and warm in nature. Enter spleen meridian and lung meridian. Regulating qi-flowing, stimulating appetite, eliminating dampness and resolving phlegm, and treating spleen and stomach diseases.

Semen astragali Complanati is warm in nature and sweet in taste. Enter liver meridian and kidney meridian. Warming and nourishing liver and kidney, securing essence, reducing urination and improving eyesight.

In the present invention: the senecio scandens, the white snake grass and the hypericum japonicum are monarch drugs for clearing heat and detoxicating; herba Ardisiae Japonicae, cortex Albiziae, herba Paederiae, and has effects of promoting blood circulation and removing blood stasis, and can be used as ministerial drug; bupleurum, dried orange peel and semen astragali complanati are used as adjuvant drugs for soothing liver, invigorating yang, strengthening spleen and tonifying kidney and harmonizing various drugs. The medicines are combined to play the roles of strengthening body resistance, eliminating evil and balancing yin and yang. Therefore, the traditional Chinese medicine can inhibit the growth of tumors, and obviously improve the symptoms of fever, tumor enlargement and the like of tumor patients, thereby achieving the effect of inhibiting the tumors.

The method for preparing the traditional Chinese medicine composition for treating primary liver cancer comprises the following steps:

weighing the prescription amount of senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati; adding 5-10 times of water, decocting until one fifth of water is left, and filtering to obtain decoction.

The administration method of the medicine soup comprises the following steps: the adult can take 500ml each time three times a day.

The traditional Chinese medicine composition for treating the primary liver cancer adopts dialectical theory to screen the traditional Chinese medicine composition, and the provided traditional Chinese medicine composition has the advantages of quick response, good curative effect, small side effect and obvious inhibition effect on primary tumors. The decoction is simple to prepare, convenient to take clinically, safe to use and high in operability.

Drawings

FIG. 1 is a time-tumor volume plot;

fig. 2 is a time-tumor weight plot.

Detailed Description

Example 1

The traditional Chinese medicine composition for treating primary liver cancer comprises the following components in parts by weight: 50 parts of senecio scandens, 40 parts of white snake grass, 30 parts of ground grass, 30 parts of Japanese ardisia herb, 10 parts of cortex albiziae, 10 parts of fevervine, 25 parts of radix bupleuri, 15 parts of dried orange peel and 20 parts of semen astragali complanati.

Weighing the prescription amount of senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati; adding 5-10 times of water, decocting until one fifth of water is left, and filtering to obtain decoction;

the administration method of the medicine soup comprises the following steps: the adult can take 500ml each time three times a day.

Example 2

The traditional Chinese medicine composition for treating primary liver cancer comprises the following components in parts by weight: 30 parts of senecio scandens, 20 parts of white snake grass, 10 parts of ground otope herb, 10 parts of Japanese ardisia herb, 10 parts of cortex albiziae, 10 parts of fevervine, 10 parts of radix bupleuri, 10 parts of dried orange peel and 25 parts of semen astragali complanati.

Weighing the prescription amount of senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati; adding 5-10 times of water, decocting until one fifth of water is left, and filtering to obtain decoction;

the administration method of the medicine soup comprises the following steps: the adult can take 500ml each time three times a day.

Example 3

The traditional Chinese medicine composition for treating primary liver cancer comprises the following components in parts by weight: 45 parts of senecio scandens, 35 parts of white snake grass, 25 parts of ground grass, 25 parts of Japanese ardisia herb, 15 parts of cortex albiziae, 20 parts of fevervine, 15 parts of radix bupleuri, 20 parts of dried orange peel and 30 parts of semen astragali complanati.

Weighing the prescription amount of senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati; adding 5-10 times of water, decocting until one fifth of water is left, and filtering to obtain decoction;

the administration method of the medicine soup comprises the following steps: the adult can take 500ml each time three times a day.

Example 4

The traditional Chinese medicine composition for treating primary liver cancer comprises the following components in parts by weight: 40 parts of senecio scandens, 30 parts of white snake grass, 20 parts of ground grass, 20 parts of Japanese ardisia herb, 12 parts of cortex albiziae, 30 parts of fevervine, 30 parts of radix bupleuri, 30 parts of dried orange peel and 40 parts of semen astragali complanati;

weighing the prescription amount of senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati; adding 5-10 times of water, decocting until one fifth of water is left, and filtering to obtain decoction;

the administration method of the medicine soup comprises the following steps: the adult can take 500ml each time three times a day.

Test examples

1. Preparing a mouse liver cancer model, and testing whether the mouse liver cancer model has the effect of reducing the tumor volume and the tumor weight

(1) After passage of tumor strain through Kunming mouse for 6d, cervical dislocation is treated to kill the mouse, the milky ascites of the mouse is aseptically taken, and diluted into tumor cell suspension with sterile physiological saline according to a ratio of 1:3.5; the tumor cell suspension is extracted, and 0.2 ml/mouse is inoculated under the skin of the armpit of the right forelimb after conventional disinfection, so that an animal model of solid tumor is prepared.

(2) Weighing after inoculation, dividing the mice into 2 groups according to Latin method, wherein each group comprises 10 mice, namely (1) a control group (2) a dosing group; the formulation described in example 1 was administered to the lavage at 13.5g/kg (0.2 ml/10 g) and the control group was administered the same volume of potable water; the body weight of the mice was measured at the beginning and end of the experiment, respectively, and attention was paid to observing the general condition of the mice.

(3) The method comprises the steps of weighing the volume of a mouse every day, weighing the mouse after stopping taking the medicine, killing the mouse after cervical dislocation, forceps the skin of the growing part of the right armpit tumor of the mouse, then cutting the skin by using a surgical scissors, exposing the tumor, blunt peeling the tumor by using the surgical scissors, and weighing the tumor by using an electronic balance. The specific time-tumor volume and time-tumor weight effect are shown in fig. 1 and 2, and it can be seen from fig. 1 and 2 that the tumor volume and tumor weight are obviously reduced after 6 weeks with the lapse of the administration time, which shows that the decoction has the effect of inhibiting the growth of tumor.

2. Clinical efficacy study

(1) 200 patients with primary liver cancer which are clinically diagnosed are randomly selected, and the patients are mainly characterized by liver pain, anorexia, debilitation, emaciation, abdominal mass, limb weakness, dyspepsia, nausea, abdominal distention, anemia, ascites, edema, jaundice and the like, and liver tumors are visible in CT examination.

(2) The administration method comprises the following steps:

the adult can take 500ml each time three times a day.

(3) Curative effect: effective (symptoms are improved, cancer focus is reduced by more than half, and other objective examination is obviously improved); ineffective (no improvement in symptoms or objective examination). The specific clinical effects are shown in Table 1.

TABLE 1 clinical effects of primary liver cancer treatment

Clinical experiments prove that the total effective rate of the traditional Chinese medicine formula provided by the invention on primary liver cancer is 90%, wherein the traditional Chinese medicine formula disclosed by the embodiment 1 has the best effect, and the traditional Chinese medicine formula can obviously reduce the tumor area and weight after being taken for more than half a year.

Treatment of cancer examples:

1. plum XX, woman, 72 years old, shandong, liver pain, anorexia, debilitation, CT examination in hospital at 2018 at 7 month and 3 days, liver cancer diagnosis, 5cm x 6cm tumor, taking the decoction for more than 2 months, and checking to reduce tumor to 2cm x 3cm.

2. Zhao XX, male, 68 years old, shandong, anorexia, abdominal distention, nausea, CT in hospital at 10 month 9 of 2019, puncture pathological examination, liver cancer, tumor of 8cm x 9cm, taking the decoction for more than 3 months, and checking to reduce tumor to 6cm x 7cm.

3. Grand XX, male, 70 years old, shandong, vomiting, diarrhea, abdominal distention, and in hospital PETCT at 30 days of 2020, pathologically diagnosed liver cancer, 6cm x 7cm tumor, taking the decoction for more than 5 months, and checking to reduce tumor to 3cm x 3cm.

The above examples demonstrate that: the traditional Chinese medicine composition has the effects of strengthening body resistance to eliminate pathogenic factors and balancing yin and yang, can inhibit the growth of tumors, and can obviously improve the symptoms of fever, tumor enlargement and the like of tumor patients, thereby achieving the effect of inhibiting the tumors.

Claims (4)

1. A traditional Chinese medicine composition for treating primary liver cancer is characterized in that: the composite material consists of the following components in parts by weight: 30-50 parts of senecio scandens, 20-40 parts of white snake grass, 10-30 parts of ground grass, 10-30 parts of Japanese ardisia herb, 10-30 parts of cortex albiziae, 10-30 parts of fevervine, 10-30 parts of radix bupleuri, 10-30 parts of dried orange peel and 20-40 parts of semen astragali complanati;

weighing the prescription amount of senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati; adding 5-10 times of water, decocting until one fifth of water is left, and filtering to obtain decoction;

the administration method of the medicine soup comprises the following steps: the adult can take 500ml each time three times a day.

2. The traditional Chinese medicine composition for treating primary liver cancer according to claim 1, which is characterized in that: the composite material consists of the following components in parts by weight: 40-50 parts of senecio scandens, 30-40 parts of white snake grass, 20-30 parts of ground grass, 25-30 parts of Japanese ardisia herb, 10-15 parts of cortex albiziae, 10-20 parts of fevervine, 10-15 parts of radix bupleuri, 10-20 parts of dried orange peel and 20-30 parts of semen astragali complanati.

3. The traditional Chinese medicine composition for treating primary liver cancer according to claim 1, which is characterized in that: the composite material consists of the following components in parts by weight: 50 parts of senecio scandens, 40 parts of white snake grass, 30 parts of ground grass, 30 parts of Japanese ardisia herb, 10 parts of cortex albiziae, 10 parts of fevervine, 25 parts of radix bupleuri, 15 parts of dried orange peel and 20 parts of semen astragali complanati.

4. A method for preparing the traditional Chinese medicine composition according to claims 1-3, characterized in that: weighing the prescription amount of senecio scandens, white snake grass, hypericum japonicum, japanese ardisia herb, cortex albiziae, fevervine, radix bupleuri, dried orange peel and semen astragali complanati; adding 5-10 times of water, decocting until one fifth of water is left, and filtering to obtain decoction;

the administration method of the medicine soup comprises the following steps: the adult can take 500ml each time three times a day.

Images