CN109464517A - Clearing heat and detoxicating paediatrics external application massage ointment formula, the method and application for preparing ointment - Google Patents
Clearing heat and detoxicating paediatrics external application massage ointment formula, the method and application for preparing ointment Download PDFInfo
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Abstract
The invention discloses a kind of clearing heat and detoxicating paediatrics external applications to massage ointment formula, Chinese medicine material including following parts by weight: 1~5 parts by weight of radix bupleuri, 1~5 parts by weight of pueraria lobata, 1~5 parts by weight of honeysuckle, 1~5 parts by weight of Fructus Forsythiae, 2~8 parts by weight of gypsum, 1~3 parts by weight of peppermint, 1~8 parts by weight of sweet wormwood, 1~3 parts by weight of schizonepeta, 1~3 parts by weight of 1~4 parts by weight of cape jasmine and rheum officinale；The invention also discloses the application of the method and ointment of ointment in massage therapy is prepared using above-mentioned formula.The bright and clean exquisiteness of ointment is massaged in paediatrics external application produced by the present invention with antipyretic and antidote functions, is not easy pollution clothes；Using comfortable, it is easy to as infant receiving.Clearing heat and detoxicating paediatrics external application massage ointment is emulsion, and transdermal characteristic is good, is played a role conducive to drug to human body, has exact curative effect to cold in children fever.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, and in particular to a kind of clearing heat and detoxicating paediatrics external application massage ointment formula and
Preparation method and application.
Background technique
Currently, the treatment method that the room of controlling mainly uses outside paediatrics has acupuncture, massage and external-applied ointment etc..Outside Chinese medicine
Therapy is because curative for effect, and without taking medicine, toxic side effect is small, deep to be favored by patient.Wherein external-applied ointment be all by drug crush with
Afterwards, Auxiliary Liquid Material such as ginger juice or vinegar is added and is tuned into paste, be pasted at acupuncture point.Although this drug usage mode curative effect is true
It cuts, but shows big, thick, the black feature of Chinese medicine fully.Its disadvantage mainly has: (1) medicament appearance is poor, skin clothing easy to pollute；(2) medicine
Object transdermal characteristic is poor, and mechanism of action is indefinite；(3) it is sticked using adhesive plaster, the easy allergy of part infant；(4) there is foreign body sensation after sticking, suffer from
Youngster's compliance is poor；(5) need to be ready-to-use, it is not easy to store.
In addition, paediatrics massage is mostly used talcum powder as lubricant now, in order to avoid damage skin.But Chinese medicine thinks, talcum
Mealiness is cold, has the effect of inducing diuresis for treating strangurtia, clearing away summerheat, clearing damp sore；For affection of exogenous wind-cold, disease caused by internal injury is raw and cold is simultaneously
It is improper, therefore this makes talcum powder not have blanket property as the method for lubricant.
Cold, fever is paediatrics common sympton, and at present for fever in children, the mode for generalling use infusion of having an injection is controlled
It treats, which results in the abuse phenomenons of antibiotic, can excessively accelerate the sprawling of drug-resistant bacteria using antibiotic, are unfavorable for the whole of country
Body medical and health care system threatens to long-term national health.It takes medicine, takes effect relatively slow, while children being forced to take medicine to parent
It is also a more difficult thing.Therefore, it is necessary to which development is easy to the flu received for children except traditional having an injection is taken medicine
Fever therapy scheme.
Summary of the invention
The purpose of the present invention is to provide a kind of clearing heat and detoxicating paediatrics external applications to massage ointment formula, is formulated the soft of preparation according to this
Cream has a better effect the cold, fever infant that symptoms are mild tool, is easy to as children's receiving.
To achieve the above object, clearing heat and detoxicating paediatrics external application of the invention massage ointment formula includes in following parts by weight
Medicine raw material: 1~5 parts by weight of radix bupleuri, 1~5 parts by weight of pueraria lobata, 1~5 parts by weight of honeysuckle, 1~5 parts by weight of Fructus Forsythiae, gypsum 2~8
Parts by weight, 1~3 parts by weight of peppermint, 1~8 parts by weight of sweet wormwood, 1~3 parts by weight of schizonepeta, 1~4 parts by weight of cape jasmine and rheum officinale 1~
3 parts by weight；Radix bupleuri, pueraria lobata, honeysuckle, Fructus Forsythiae, gypsum, peppermint, sweet wormwood, schizonepeta, cape jasmine and rheum officinale form medicine group.
It further include having matrix and deionized water in addition to medicine group.
The matrix includes oil phase part point and aqueous portion, and oil phase part point includes stearic acid, atoleine and solid paraffin；
Aqueous portion includes borax, glycerol, triethanolamine and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of atoleine, solid paraffin 17
~19 parts by weight；0.1~0.5 parts by weight of borax, 3.0~5.0 parts by weight of glycerol, 0. 1~0.3 parts by weight of triethanolamine, Buddhist nun
Moor 0.2~0.5 parts by weight of golden ethyl ester.
The matrix includes oil phase part point and aqueous portion, and oil phase part point includes stearic acid, glycerol monostearate and Bai Fan
Intellectual circle；Aqueous portion includes potassium hydroxide, glycerol and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of glycerol monostearate, Bai Fanshi
17~19 parts by weight of woods；0.1~0.5 parts by weight of potassium hydroxide, 3.0~5.0 parts by weight of glycerol, ethylparaben 0.2~0.5
Parts by weight.
The matrix includes oil phase part point and aqueous portion, and oil phase part point includes stearic acid, stearyl alcohol, albolene and liquid
Body paraffin；Aqueous portion includes Tween-80, Arlacel-60, glycerol and sorbic acid；
The weight proportion of each component are as follows:
17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of stearyl alcohol, 17~19 parts by weight of albolene, atoleine 2~
4 parts by weight；Tween-80 is 3.0~5.0 parts by weight, and Arlacel-60 is 0.1~0.5 parts by weight, and glycerol is 8~12 parts by weight, mountain
Pears acid is 0.2~0.5 parts by weight.
The invention also discloses the method for preparing ointment using above-mentioned clearing heat and detoxicating paediatrics external application massage ointment formula, by with
Lower step carries out:
First step is to prepare traditional medicine volatile oil using medicine group；In medicine group, radix bupleuri, Fructus Forsythiae, peppermint, sweet wormwood and schizonepeta composition
Volatile oil extracting group；
First step is specifically then to be added 8 times in container of each component addition with volume instruction for will volatilize oil extract group
It in the water of the total volume of volatile oil extracting group each component, is volatilized oil 4 hours using extraction by steam distillation, collects Chinese medicine and wave
Hair oil is spare；
Second step is to prepare Chinese medicine extract；
Second step specifically includes four sub-steps:
First sub-step is to filter the decocting liquid that volatilization oil was extracted in first step, obtains two parts substance, a part
For the dregs of a decoction, another part is the first residual filtrate；
Second sub-step is other institutes in the dregs of a decoction for obtaining the first sub-step and medicine group in addition to volatile oil extracting group
There is drug to be put into the container with volume instruction, repeats decocting extraction operation twice；The dregs of a decoction that first sub-step obtains
And drug set is extracted in other all drug composition decoctings in medicine group in addition to volatile oil extracting group；
Decocting extraction operation is: the water that drug assemblies product is extracted in 6 times of decoctings is added, decocting 1 hour, decocting liquid is filtered,
Two parts substance is obtained, a part is the dregs of a decoction, and another part is that residual filtrate is extracted in decocting, discards the dregs of a decoction；
Third sub-step is that decocting obtained in the second sub-step is extracted to residual filtrate to merge into total remain with the first residual filtrate
Remaining filtrate；
4th sub-step is to be concentrated into total surplus filtrate decompression to reach 1.1~1.15 to the relative density of water, is then added 95%
The volume content of ethanol water to ethyl alcohol reaches (75 ± 1) %, stirs evenly, after standing 24 hours, recycling supernatant to supernatant
The supernatant of recycling is concentrated into without ethanol flavor and reaches 1.1 ± 0.05 to the relative density of water, obtain Chinese medicine extract by liquid；
Third step is that the oil phase part of matrix point is added in traditional medicine volatile oil after mixing, is obtained containing in oil phase part point
Medicine volatile oil, stirs evenly, and keeps the temperature at 80 DEG C spare；
Four steps is the traditional Chinese medicine extraction prepared in whole or most of components and second step in the aqueous portion by matrix
Liquid is added in deionized water, is added in the third step traditional medicine volatile oil obtained containing oil phase part point after being completely dissolved, mixing
The cooling paediatrics external application massage ointment obtained with antipyretic and antidote functions after uniformly；Paediatrics external application with antipyretic and antidote functions
It massages in ointment, the total weight parts of matrix and deionized water are 70~95 parts, the weight of the Chinese medicine extract of second step preparation
Part is 5~10 parts, and the parts by weight for the traditional medicine volatile oil collected in first step are 0.01~0.1 part；
In the 4th sub-step of second step, before the supernatant concentration that will be recycled, water, amount of water are added in the supernatant of recycling
It is 2/3rds of the ethyl alcohol volume being added in the 4th sub-step, then refrigerates 24 hours under the conditions of 2~8 DEG C, take again
Clear liquid, finally concentrated supernatant again.
Third step is specifically:
The oil phase part of matrix point is stirred after stearic acid, atoleine and solid paraffin are mixed and heated to 150 DEG C, stearic acid is made
It is dissolved in paraffin and is uniformly mixed；80 DEG C are subsequently cooled to, is added in traditional medicine volatile oil, and be added in the aqueous portion of matrix
Ethylparaben, stir evenly, kept the temperature at 80 DEG C spare；
Four steps is specifically:
By remaining ingredient, that is, borax of Chinese medicine extract obtained in the 4th sub-step of second step and the aqueous portion of matrix,
Glycerol and triethanolamine are added in deionized water；On the basis of the weight proportion of each component in matrix, the dosage of deionized water is
60~70 parts by weight；
It is then heated at 80 DEG C and dissolves, the third step Chinese medicine volatilization obtained containing oil phase part point is added until completely dissolved
It in oil, stirs while adding, is uniformly mixed, the cooling paediatrics external application massage obtained with antipyretic and antidote functions is soft after packing
Cream.
Third step is specifically:
By the ethylparaben in the oil phase part of matrix point i.e. stearic acid, glycerol monostearate and albolene and aqueous portion
Stirring and dissolving after being mixed and heated to 100 DEG C is cooled to 80 DEG C after mixing, is added in traditional medicine volatile oil, stirs evenly, 80 DEG C
Lower heat preservation is spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and remaining ingredient, that is, hydrogen-oxygen of the aqueous portion of matrix
Change potassium and glycerol to be added in deionized water, on the basis of the weight proportion of each component in matrix, the dosage of deionized water is 60~
70 parts by weight；
It is then heated at 80 DEG C and dissolves, be added in third step 80 DEG C containing oil phase part point obtained until completely dissolved
In medicine volatile oil, stir while adding, be uniformly mixed, after packing it is cooling obtain the paediatrics external application with antipyretic and antidote functions by
Rub ointment.
Third step is specifically:
The oil phase part of matrix point i.e. stearic acid, stearyl alcohol, albolene and atoleine is mixed and heated to after 150 DEG C stir it is molten
Solution is cooled to 80 DEG C after mixing, is added in traditional medicine volatile oil, stirs evenly, keep the temperature at 80 DEG C spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and aqueous portion, that is, Tween-80, the sapn-of matrix
60, glycerol and sorbic acid are added in deionized water, and on the basis of the weight proportion of each component in matrix, the dosage of deionized water is
60~70 parts by weight；
It is then heated at 80 DEG C and dissolves, be added in third step 80 DEG C containing oil phase part point obtained until completely dissolved
In medicine volatile oil, stir while adding, be uniformly mixed, after packing it is cooling obtain the paediatrics external application with antipyretic and antidote functions by
Rub ointment.
The invention also discloses the paediatrics external application massages with antipyretic and antidote functions of the above-mentioned method preparation for preparing ointment
Application of the ointment in massage therapy, when use, are directly used in human body, do not mount between drug and human body material and adhesive plaster.
The present invention has the advantage that:
The bright and clean exquisiteness of ointment is massaged in paediatrics external application produced by the present invention with antipyretic and antidote functions, is not easy pollution clothes；It uses
Comfortably, it is easy to as infant receiving.Clearing heat and detoxicating paediatrics external application massage ointment is emulsion, and transdermal characteristic is good, is conducive to drug and sends out human body
The effect of waving has exact curative effect to cold in children fever.
Clearing heat and detoxicating paediatrics external application massage ointment produced by the present invention using when do not need mount material and adhesive plaster, Neng Gouzhi
Use is connect, adhesive plaster etc. is avoided to mount the stimulation of materials on skin.In contrast, the medicine used when paediatrics in the prior art is massaged
Object and lubricant are easy pollution clothes and human body, not easy to clean, therefore need that mounting is arranged between drug and human body when use
It sticks one piece of cloth or paper on top of another material and adhesive plaster, not can avoid the stimulation of material and adhesive plaster to skin of mounting.
When use after massage rubbing, medicaments uniformity is coated with skin, and without foreign body sensation, children compared with the past are easier to connect
It is treated；Clearing heat and detoxicating paediatrics external application massage ointment made of the present invention has facilitation for the absorption of drug, with use
Other lubricants are compared, hence it is evident that improve cure rate.
Clearing heat and detoxicating paediatrics external application massage ointment made of the present invention is used, carries and is stored and is convenient, without current existing
Match, greatly facilitate use, be suitable for popularization and application, and saved the extemporaneous preparation time, hence it is evident that improves the effect of massage therapy
Rate had both saved the waiting time of patient, allows hospital to accept more patients for medical treatment within the unit time, also improves hospital
Profitability.
Clearing heat and detoxicating paediatrics external application massage ointment of the invention is made of using conventional Chinese medicine, and raw material is easy to get, safe and non-toxic
Side effect can not only rise by obtained clearing heat and detoxicating paediatrics external application massage salve application in the massage agent of a variety of dosage forms
To lubricating action, also have effects that treat cold, fever, is suitble to promote and apply.The method process peace for preparing ointment of the invention
Row rationally, to prepare clearing heat and detoxicating paediatrics external application massage ointment provides effective way, and preparation efficiency and yields are higher.
In the 4th sub-step of second step, will recycling supernatant to supernatant without ethanol flavor after, remaining supernatant substance
In dense phase, wherein the substance poor containing some substances undissolvable in water and solubility.If not by the portion
Divide substance removal, then the clearing heat and detoxicating paediatrics external application massage ointment finally prepared will be more coarse, and skin feel is poor, is easy
Cause the discomfort of infant.After substance not soluble in water is removed, the clearing heat and detoxicating paediatrics external application massage ointment finally prepared will
In use to infant with the sense of touch of smooth exquisiteness, to bring comfortable feeling to infant, make infant in the state of comfortable
Receive to use therapeutic scheme of the invention, is more advantageous to treatment infant.It is refrigerated 24 hours under the conditions of 2~8 DEG C, can reduce dissolution
Degree, is more advantageous to the precipitation of substance that is not soluble in water or being insoluble in water.
Pharmacology of various herbs act in the present invention:
Radix bupleuri: it is pungent, bitter, it is slightly cold.Return liver, gallbladder, lung channel.The effect of tool evacuation is brought down a fever, soothing liver-qi stagnation, lifting disease.For catching a cold
Fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, uterine prolapse, rectal prolapse.
Pueraria lobata: it is sweet, pungent, it is cool.Returns spleen, stomach, lung channel.It brings down a fever, promotes the production of body fluid to quench thirst with expelling pathogenic factors from muscles and skin, promoting eruption, Shengyang Zhixie, promoting menstruation work
The effect of network, relieving alcoholism.It has a headache for fever caused by exogenous pathogens, stiff nape and back is thirsty, it quenches one's thirst, measles without adequate eruption, hot dysentery, diarrhea, dizziness head
Bitterly, hemiplegia, chest impediment and cardialgia, wine poison hurt medium disease.
Honeysuckle: it is sweet, it trembles with fear.Return lung, the heart, stomach meridian.Has effects that clearing heat and detoxicating, dispelling wind and heat from the body, for being used for carbuncle swells malignant boil
Sore, sore throat, erysipelas, toxic-heat and blood stasis, wind-heat cold, warm disease and fever.
Fructus Forsythiae: it is bitter, it is slightly cold.Return lung, the heart, small intestinl channel.With clearing heat and detoxicating, the effect of dispersing swelling and dissipating binds, dispelling wind and heat from the body.With
In ulcer, scrofula, acute mastitis, erysipelas, anemopyretic cold, warm disease is from the beginning of warm is joined the army, hyperpyrexia polydipsia, coma macular eruption, puckery pain of heat gonorrhea.
Gypsum: pungent, sweet, Great Cold.Enter lung, stomach meridian.With clearing heat-fire, the effect of restraining myogenic.For warm heat disease, lung stomach
The diseases such as big heat, hyperpyrexia, thirsty, fidgety, large and bounding pulse.
Peppermint: it is pungent, it is cool.Return lung, Liver Channel.With dispelling wind and heat from the body, the effect of head clearing, relieving sore-throat, promoting eruption, soothing the liver promoting the circulation of qi.
For anemopyretic cold, wind-warm syndrome is from the beginning of, headache, hot eyes, sore throat, aphtha, rubeola, morbilli, Breast bilges frowsty.
Sweet wormwood: bitter, acrid, cold.Return liver, gallbladder channel.With clearind deficient heat, hectic fever due to yin is removed, solves hot summer weather, the effect of preventing malaria, removing jaundice.For
Warm heresy impairment of yin, night fever abating at dawn, fever due to yin deficiency, hectic fever due to yin labor heat, summer-heat evil fever, malaria fever and chills, jaundice with damp-heat pathogen.
Schizonepeta: pungent, tepor.Return lung, Liver Channel.With inducing diaphoresis relieve heat, the effect of promoting eruption, the sore that disappears.For catching a cold, headache, fiber crops
Rash, rubeola, sore from the beginning of.
Cape jasmine: it is bitter, it trembles with fear.Return heart, lung, tri-jiao channel.With purging intense heat relieving restlessness, the effect of clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body；External application disappears
Swollen analgesic.For Vexed, jaundice with damp-heat pathogen, the puckery pain of stranguria, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles；Bruise is controlled outside
Bitterly.
Rheum officinale: it is bitter, it trembles with fear.Returns spleen, stomach, large intestine, liver, pericardium channel.With heat and toxic materials clearing away, clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, by the stasis of blood
The effect of promoting menstruation, removing dampness through diuresis and removing jaundice.It stagnates constipation for real heat, blood-head spits mandrill, hot eyes pharynx swelling, carbuncle swells furunculosis, abdominalgia with intestinal abscess, hemostasis
Menostasis, postpartum stasis, traumatic injury, damp-heat dysentery, jaundice and reddish urine, stranguria, oedema；Externally treating burns and scalds.
Specific embodiment
The invention discloses a kind of clearing heat and detoxicating paediatrics external applications to massage ointment formula, and the Chinese medicine including following parts by weight is former
Material: 1~5 parts by weight of radix bupleuri, 1~5 parts by weight of pueraria lobata, 1~5 parts by weight of honeysuckle, 1~5 parts by weight of Fructus Forsythiae, 2~8 weight of gypsum
Part, 1~3 parts by weight of peppermint, 1~8 parts by weight of sweet wormwood, 1~3 parts by weight of schizonepeta, 1~3 weight of 1~4 parts by weight of cape jasmine and rheum officinale
Measure part；Radix bupleuri, pueraria lobata, honeysuckle, Fructus Forsythiae, gypsum, peppermint, sweet wormwood, schizonepeta, cape jasmine and rheum officinale form medicine group.
In addition to medicine group, clearing heat and detoxicating paediatrics external application massage ointment formula further includes having matrix and deionized water, matrix packet
Include oil phase part point and aqueous portion.
The invention also discloses the method for preparing ointment using above-mentioned clearing heat and detoxicating paediatrics external application massage ointment formula, by with
Lower step carries out:
First step is to prepare traditional medicine volatile oil using medicine group；In medicine group, radix bupleuri, Fructus Forsythiae, peppermint, sweet wormwood and schizonepeta composition
Volatile oil extracting group；
First step is specifically then to be added 8 times in container of each component addition with volume instruction for will volatilize oil extract group
It in the water of the total volume of volatile oil extracting group each component, is volatilized oil 4 hours using extraction by steam distillation, collects Chinese medicine and wave
Hair oil is spare；
Second step is to prepare Chinese medicine extract；
Second step specifically includes four sub-steps:
First sub-step is to filter the decocting liquid that volatilization oil was extracted in first step, obtains two parts substance, a part
For the dregs of a decoction, another part is the first residual filtrate；
Second sub-step is other institutes in the dregs of a decoction for obtaining the first sub-step and medicine group in addition to volatile oil extracting group
There is drug to be put into the container with volume instruction, repeats decocting extraction operation twice；The dregs of a decoction that first sub-step obtains
And drug set is extracted in other all drug composition decoctings in medicine group in addition to volatile oil extracting group；
Decocting extraction operation is: the water that drug assemblies product is extracted in 6 times of decoctings is added, decocting 1 hour, decocting liquid is filtered,
Two parts substance is obtained, a part is the dregs of a decoction, and another part is that residual filtrate is extracted in decocting, discards the dregs of a decoction；
Third sub-step is that decocting obtained in the second sub-step is extracted to residual filtrate to merge into total remain with the first residual filtrate
Remaining filtrate；
4th sub-step is to be concentrated into total surplus filtrate decompression to reach the relative density of water to measure at 1.1~1.15(60 DEG C
Relative density), 95% ethanol water (i.e. the volume ratio of ethyl alcohol and water be 95:5 aqueous solution) is then added to the volume of ethyl alcohol
Content reaches (75 ± 1) %, stirs evenly, and after standing 24 hours, recycling supernatant is to supernatant without ethanol flavor (even if ethyl alcohol fills
Divide evaporation, at this time in compared with dense phase), the supernatant of recycling is concentrated into, 1.1 ± 0.05(60 DEG C is reached to the relative density of water
Lower measurement relative density), obtain Chinese medicine extract；
Third step is that the oil phase part of matrix point is added in traditional medicine volatile oil after mixing, is obtained containing in oil phase part point
Medicine volatile oil (namely oil phase part containing traditional medicine volatile oil point), stirs evenly, keeps the temperature at 80 DEG C spare；
Four steps is the traditional Chinese medicine extraction prepared in whole or most of components and second step in the aqueous portion by matrix
Liquid is added in deionized water, is added in the third step traditional medicine volatile oil obtained containing oil phase part point after being completely dissolved, mixing
It is cooling after uniformly to obtain clearing heat and detoxicating paediatrics external application massage ointment；In clearing heat and detoxicating paediatrics external application massage ointment, matrix and go
The total weight parts of ionized water are 70~95 parts, and the parts by weight of the Chinese medicine extract of second step preparation are 5~10 parts, first step
The parts by weight of the traditional medicine volatile oil of middle collection are 0.01~0.1 part.
In the 4th sub-step of second step, before the supernatant concentration that will be recycled, water is added in the supernatant of recycling, adds
Water is 2/3rds of ethyl alcohol volume be added in the 4th sub-step, then refrigerates 24 hours under the conditions of 2~8 DEG C, again
Supernatant is taken, finally concentrated supernatant again.
The invention also discloses the paediatrics external application massages with antipyretic and antidote functions of the above-mentioned method preparation for preparing ointment
Application of the ointment in massage therapy, when use, are directly used in human body, do not mount between drug and human body material and adhesive plaster.
Embodiment one
It include the Chinese medicine material of following parts by weight: 1 parts by weight of radix bupleuri, pueraria lobata 1 in clearing heat and detoxicating paediatrics external application massage ointment formula
Parts by weight, 5 parts by weight of honeysuckle, 1 parts by weight of Fructus Forsythiae, 2 parts by weight of gypsum, 1 parts by weight of peppermint, 1 parts by weight of sweet wormwood, 1 weight of schizonepeta
Measure part, 1 parts by weight of 1 parts by weight of cape jasmine and rheum officinale；Fried atractylodes, cortex cinnamomi, wrinkled giant hyssop, fennel seeds, the root of three-nerved spicebush, ginger, flos caryophylli and Wu
The fruit of medicinal cornel forms medicine group.
In clearing heat and detoxicating paediatrics external application massage ointment formula, the matrix includes oil phase part point and aqueous portion, oil phase part
Divide includes stearic acid, atoleine and solid paraffin；Aqueous portion includes borax, glycerol, triethanolamine and ethylparaben；
The weight proportion of matrix each component are as follows: 17 parts by weight of stearic acid, 1.0 parts by weight of atoleine, 17 weight of solid paraffin
Part；0.1 parts by weight of borax, 3.0 parts by weight of glycerol, 0. 1 parts by weight of triethanolamine, 0.4 parts by weight of ethylparaben.
The third step for preparing the method for ointment is specifically:
The oil phase part of matrix point is stirred after stearic acid, atoleine and solid paraffin are mixed and heated to 150 DEG C, stearic acid is made
It is dissolved in paraffin and is uniformly mixed；80 DEG C are subsequently cooled to, is added in traditional medicine volatile oil, and be added in the aqueous portion of matrix
Ethylparaben, keep the temperature at 80 DEG C spare；
The four steps for preparing the method for ointment is specifically:
By remaining ingredient, that is, borax of Chinese medicine extract obtained in the 4th sub-step of second step and the aqueous portion of matrix,
Glycerol and triethanolamine are added in deionized water, and on the basis of the weight proportion of each component in matrix, the dosage of deionized water is
60~70 parts by weight；
It is then heated at 80 DEG C and dissolves, be slowly added to the third step Chinese medicine obtained containing oil phase part point until completely dissolved
It in volatile oil, stirs while adding, is uniformly mixed, the cooling paediatrics external application massage obtained with antipyretic and antidote functions after packing
Ointment.
Packing is to massage ointment for the ease of storage, transport and using clearing heat and detoxicating paediatrics external application.Difficulty is dispensed after cooling
Increase, therefore should be dispensed before cooling.
Embodiment two
Clearing heat and detoxicating paediatrics external application massage ointment formula includes the Chinese medicine material of following parts by weight: 5 parts by weight of radix bupleuri, 5 weight of pueraria lobata
Measure part, 1 parts by weight of honeysuckle, 5 parts by weight of Fructus Forsythiae, 8 parts by weight of gypsum, 3 parts by weight of peppermint, 8 parts by weight of sweet wormwood, 3 weight of schizonepeta
Part, 3 parts by weight of 4 parts by weight of cape jasmine and rheum officinale；Fried atractylodes, cortex cinnamomi, wrinkled giant hyssop, fennel seeds, the root of three-nerved spicebush, ginger, flos caryophylli and Wu Zhu
Cornel forms medicine group.
In clearing heat and detoxicating paediatrics external application massage ointment formula, the matrix includes oil phase part point and aqueous portion, oil phase part
Divide includes stearic acid, glycerol monostearate and albolene；Aqueous portion includes potassium hydroxide, glycerol and ethylparaben；
The weight proportion of matrix each component are as follows: 19 parts by weight of stearic acid, 3.0 parts by weight of glycerol monostearate, albolene 19
Parts by weight；0.5 parts by weight of potassium hydroxide, 5.0 parts by weight of glycerol, 0.5 parts by weight of ethylparaben.
The third step for preparing the method for ointment is specifically: by the oil phase part of matrix point i.e. stearic acid, glycerol monostearate
Stirring and dissolving after being mixed and heated to 100 DEG C with the ethylparaben in albolene and aqueous portion, cools down after mixing
To 80 DEG C, it is added in traditional medicine volatile oil, stirs evenly, kept the temperature at 80 DEG C spare；
The four steps for preparing the method for ointment is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and remaining ingredient, that is, hydrogen-oxygen of the aqueous portion of matrix
Change potassium and glycerol to be added in deionized water, on the basis of the weight proportion of each component in matrix, the dosage of deionized water is 60~
70 parts by weight；
It is then heated at 80 DEG C and dissolves, be slowly added to third step 80 DEG C containing oil phase part point obtained until completely dissolved
Traditional medicine volatile oil in, stir while adding, be uniformly mixed, packing after cooling obtain outside the paediatrics with antipyretic and antidote functions
With massage ointment.
Embodiment three
Clearing heat and detoxicating paediatrics external application massage ointment formula includes the Chinese medicine material of following parts by weight: 3 parts by weight of radix bupleuri, 3 weight of pueraria lobata
Measure part, 3 parts by weight of honeysuckle, 3 parts by weight of Fructus Forsythiae, 5 parts by weight of gypsum, 2 parts by weight of peppermint, 4 parts by weight of sweet wormwood, 2 weight of schizonepeta
Part, 2 parts by weight of 3 parts by weight of cape jasmine and rheum officinale；
In clearing heat and detoxicating paediatrics external application massage ointment formula, the matrix includes oil phase part point and aqueous portion, oil phase part subpackage
Include stearic acid, stearyl alcohol, albolene and atoleine；Aqueous portion includes Tween-80, Arlacel-60, glycerol and sorbic acid；
The weight proportion of matrix each component are as follows:
18 parts by weight of stearic acid, 2 parts by weight of stearyl alcohol (octadecyl alcolol), 18 parts by weight of albolene, 3 parts by weight of atoleine；It spits
Temperature -80 is 4 parts by weight, and Arlacel-60 is 0.3 parts by weight, and glycerol is 10 parts by weight, and sorbic acid is 0.4 parts by weight.
The third step for preparing the method for ointment is specifically:
I.e. stearic acid, stearyl alcohol (octadecyl alcolol), albolene and the atoleine of the oil phase part of matrix point is mixed and heated to 150 DEG C
Stirring and dissolving afterwards is cooled to 80 DEG C after mixing, is added in traditional medicine volatile oil, stirs evenly, keep the temperature at 80 DEG C spare；
The four steps for preparing the method for ointment is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and aqueous portion, that is, Tween-80, the sapn-of matrix
60, glycerol and sorbic acid are added in deionized water, and on the basis of the weight proportion of each component in matrix, the dosage of deionized water is
60~70 parts by weight；
It is then heated at 80 DEG C and dissolves, be slowly added to third step 80 DEG C containing oil phase part point obtained until completely dissolved
Traditional medicine volatile oil in, stir while adding, be uniformly mixed, packing after cooling obtain outside the paediatrics with antipyretic and antidote functions
With massage ointment.
Clinical observation on the therapeutic effect
Diagnostic criteria: diagnostic criteria referring in " TCM Pediatrics common disease practice guidelines " diagnostic criteria and diagnostic point and
Related standard formulation in " new Chinese medicine guideline of clinical investigations ".
It is included in standard: (1) meeting children's exogenous chill or anemopyretic cold person, to generate heat for main clinic symptoms, with other
Upper respiratory tract related symptoms, such as runny nose, nasal obstruction, sneeze, cough, blood routine examination is generally normal or visible total white blood cells,
Neutrophil leucocyte is higher or relatively low；Chest X line piece is normal, and (2) course of disease was less than 5 days, and body temperature is at 38.5 DEG C hereinafter, the age is 1
Between -10 years old years；(3) be ready it is tested, and by parent sign informed consent form person；(4) without other organic disease persons.
Exclusion criteria: (1) it does not meet above-mentioned diagnostic criteria and is included in standard.It (2) can not partner treatment person.(3) lung is tight
Double infection infectious diseases and other organic disease persons.
Observation method: ointment is massaged using the paediatrics external application with antipyretic and antidote functions prepared by embodiment three by treatment group
It is treated as lubricant using manual massage.Control group is treated as lubricant using manual massage using talcum powder.Continuously control
Treatment 5 days, once a day.Other medicines are not used during treatment, be careful in one's diet daily life.
Curative effect determinate standard: referring to Ministry of Health of the People's Republic of China 2002 formulate " new Chinese medicine clinical research refers to
Lead principle " it formulates.Clinical cure: infant temperature recovery to normal range (NR), clinical symptoms completely disappear；Improve: infant body temperature is extensive
Again to normal range (NR), clinical symptoms are substantially reduced；Invalid: infant body temperature clinical symptoms are substantially reduced；It is invalid: infant body temperature not under
It is down to normal range (NR) or has raising sign.Efficacy determination be cure or improve be accordingly to be regarded as effectively.Total effective rate=(healing number of cases+
Improvement number of cases)/total number of cases × 100%；Cure rate=healing number of cases/total number of cases × 100%.
Treatment results: treatment group enters group 30, and control group enters group 30, two groups totally 60.After treatment 5 days, treatment group fullys recover from an illness
More 25, effective 4, invalid 1；Control group is fully recovered 20, effective 8, invalid 2.Compare statistics Chi-square Test.As a result
It see the table below.
Note: P value is the parameter for determining hypothesis testing result, exactly the obtained sample view when null hypothesis is true
As a result or more extreme result occur probability.P value is smaller, shows that result is more significant.P value shows less than 0.05 or less than 0.01
It is statistically significant.
Treatment results are through chi-square criterion, and treatment group's total effective rate and control group no significant difference (P > 0.05), treatment group fullys recover from an illness
More rate and control group has notable difference (P < 0.05), and treatment group's therapeutic effect is substantially better than control group.
The above embodiments are only used to illustrate and not limit the technical solutions of the present invention, although referring to above-described embodiment to this hair
It is bright to be described in detail, those skilled in the art should understand that: still the present invention can be modified or be waited
With replacement, without departing from the spirit or scope of the invention, or any substitutions, should all cover in power of the invention
In sharp claimed range.
Claims (10)
1. ointment formula is massaged in clearing heat and detoxicating paediatrics external application, it is characterised in that the Chinese medicine material including following parts by weight: radix bupleuri 1~
5 parts by weight, 1~5 parts by weight of pueraria lobata, 1~5 parts by weight of honeysuckle, 1~5 parts by weight of Fructus Forsythiae, 2~8 parts by weight of gypsum, peppermint 1~
3 parts by weight, 1~8 parts by weight of sweet wormwood, 1~3 parts by weight of schizonepeta, 1~3 parts by weight of 1~4 parts by weight of cape jasmine and rheum officinale；Radix bupleuri,
Pueraria lobata, honeysuckle, Fructus Forsythiae, gypsum, peppermint, sweet wormwood, schizonepeta, cape jasmine and rheum officinale form medicine group.
2. ointment formula is massaged in clearing heat and detoxicating paediatrics external application according to claim 1, it is characterised in that: in addition to medicine group,
It further include having matrix and deionized water.
3. ointment formula is massaged in clearing heat and detoxicating paediatrics external application according to claim 2, it is characterised in that: the matrix includes
Oil phase part point and aqueous portion, oil phase part point include stearic acid, atoleine and solid paraffin；Aqueous portion includes borax, sweet
Oil, triethanolamine and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of atoleine, solid paraffin 17
~19 parts by weight；0.1~0.5 parts by weight of borax, 3.0~5.0 parts by weight of glycerol, 0. 1~0.3 parts by weight of triethanolamine, Buddhist nun
Moor 0.2~0.5 parts by weight of golden ethyl ester.
4. ointment formula is massaged in clearing heat and detoxicating paediatrics external application according to claim 2, it is characterised in that: the matrix includes
Oil phase part point and aqueous portion, oil phase part point include stearic acid, glycerol monostearate and albolene；Aqueous portion includes hydrogen-oxygen
Change potassium, glycerol and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of glycerol monostearate, Bai Fanshi
17~19 parts by weight of woods；0.1~0.5 parts by weight of potassium hydroxide, 3.0~5.0 parts by weight of glycerol, ethylparaben 0.2~0.5
Parts by weight.
5. ointment formula is massaged in clearing heat and detoxicating paediatrics external application according to claim 2, it is characterised in that: the matrix includes
Oil phase part point and aqueous portion, oil phase part point include stearic acid, stearyl alcohol, albolene and atoleine；Aqueous portion includes
Tween-80, Arlacel-60, glycerol and sorbic acid；
The weight proportion of each component are as follows:
17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of stearyl alcohol, 17~19 parts by weight of albolene, atoleine 2~
4 parts by weight；Tween-80 is 3.0~5.0 parts by weight, and Arlacel-60 is 0.1~0.5 parts by weight, and glycerol is 8~12 parts by weight, mountain
Pears acid is 0.2~0.5 parts by weight.
6. the method for preparing ointment using the massage ointment formula of clearing heat and detoxicating paediatrics external application described in any one of claim 2-5,
It is characterized in that sequentially including the following steps:
First step is to prepare traditional medicine volatile oil using medicine group；In medicine group, radix bupleuri, Fructus Forsythiae, peppermint, sweet wormwood and schizonepeta composition
Volatile oil extracting group；
First step is specifically then to be added 8 times in container of each component addition with volume instruction for will volatilize oil extract group
It in the water of the total volume of volatile oil extracting group each component, is volatilized oil 4 hours using extraction by steam distillation, collects Chinese medicine and wave
Hair oil is spare；
Second step is to prepare Chinese medicine extract；
Second step specifically includes four sub-steps:
First sub-step is to filter the decocting liquid that volatilization oil was extracted in first step, obtains two parts substance, a part
For the dregs of a decoction, another part is the first residual filtrate；
Second sub-step is other institutes in the dregs of a decoction for obtaining the first sub-step and medicine group in addition to volatile oil extracting group
There is drug to be put into the container with volume instruction, repeats decocting extraction operation twice；The dregs of a decoction that first sub-step obtains
And drug set is extracted in other all drug composition decoctings in medicine group in addition to volatile oil extracting group；
Decocting extraction operation is: the water that drug assemblies product is extracted in 6 times of decoctings is added, decocting 1 hour, decocting liquid is filtered,
Two parts substance is obtained, a part is the dregs of a decoction, and another part is that residual filtrate is extracted in decocting, discards the dregs of a decoction；
Third sub-step is that decocting obtained in the second sub-step is extracted to residual filtrate to merge into total remain with the first residual filtrate
Remaining filtrate；
4th sub-step is to be concentrated into total surplus filtrate decompression to reach 1.1~1.15 to the relative density of water, is then added 95%
The volume content of ethanol water to ethyl alcohol reaches (75 ± 1) %, stirs evenly, after standing 24 hours, recycling supernatant to supernatant
The supernatant of recycling is concentrated into without ethanol flavor and reaches 1.1 ± 0.05 to the relative density of water, obtain Chinese medicine extract by liquid；
Third step is that the oil phase part of matrix point is added in traditional medicine volatile oil after mixing, is obtained containing in oil phase part point
Medicine volatile oil, stirs evenly, and keeps the temperature at 80 DEG C spare；
Four steps is the traditional Chinese medicine extraction prepared in whole or most of components and second step in the aqueous portion by matrix
Liquid is added in deionized water, is added in the third step traditional medicine volatile oil obtained containing oil phase part point after being completely dissolved, mixing
The cooling paediatrics external application massage ointment obtained with antipyretic and antidote functions after uniformly；Paediatrics external application with antipyretic and antidote functions
It massages in ointment, the total weight parts of matrix and deionized water are 70~95 parts, the weight of the Chinese medicine extract of second step preparation
Part is 5~10 parts, and the parts by weight for the traditional medicine volatile oil collected in first step are 0.01~0.1 part；
In the 4th sub-step of second step, before the supernatant concentration that will be recycled, water, amount of water are added in the supernatant of recycling
It is 2/3rds of the ethyl alcohol volume being added in the 4th sub-step, then refrigerates 24 hours under the conditions of 2~8 DEG C, take again
Clear liquid, finally concentrated supernatant again.
7. the method according to claim 6 for preparing ointment, it is characterised in that: third step is specifically:
The oil phase part of matrix point is stirred after stearic acid, atoleine and solid paraffin are mixed and heated to 150 DEG C, stearic acid is made
It is dissolved in paraffin and is uniformly mixed；80 DEG C are subsequently cooled to, is added in traditional medicine volatile oil, and be added in the aqueous portion of matrix
Ethylparaben, stir evenly, kept the temperature at 80 DEG C spare；
Four steps is specifically:
By remaining ingredient, that is, borax of Chinese medicine extract obtained in the 4th sub-step of second step and the aqueous portion of matrix,
Glycerol and triethanolamine are added in deionized water；On the basis of the weight proportion of each component in matrix, the dosage of deionized water is
60~70 parts by weight；
It is then heated at 80 DEG C and dissolves, the third step Chinese medicine volatilization obtained containing oil phase part point is added until completely dissolved
It in oil, stirs while adding, is uniformly mixed, the cooling paediatrics external application massage obtained with antipyretic and antidote functions is soft after packing
Cream.
8. the method according to claim 6 for preparing ointment, it is characterised in that: third step is specifically:
By the ethylparaben in the oil phase part of matrix point i.e. stearic acid, glycerol monostearate and albolene and aqueous portion
Stirring and dissolving after being mixed and heated to 100 DEG C is cooled to 80 DEG C after mixing, is added in traditional medicine volatile oil, stirs evenly, 80 DEG C
Lower heat preservation is spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and remaining ingredient, that is, hydrogen-oxygen of the aqueous portion of matrix
Change potassium and glycerol to be added in deionized water, on the basis of the weight proportion of each component in matrix, the dosage of deionized water is 60~
70 parts by weight；
It is then heated at 80 DEG C and dissolves, be added in third step 80 DEG C containing oil phase part point obtained until completely dissolved
In medicine volatile oil, stir while adding, be uniformly mixed, after packing it is cooling obtain the paediatrics external application with antipyretic and antidote functions by
Rub ointment.
9. the method according to claim 6 for preparing ointment, it is characterised in that: third step is specifically:
The oil phase part of matrix point i.e. stearic acid, stearyl alcohol, albolene and atoleine is mixed and heated to after 150 DEG C stir it is molten
Solution is cooled to 80 DEG C after mixing, is added in traditional medicine volatile oil, stirs evenly, keep the temperature at 80 DEG C spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and aqueous portion, that is, Tween-80, the sapn-of matrix
60, glycerol and sorbic acid are added in deionized water, and on the basis of the weight proportion of each component in matrix, the dosage of deionized water is
60~70 parts by weight；
It is then heated at 80 DEG C and dissolves, be added in third step 80 DEG C containing oil phase part point obtained until completely dissolved
In medicine volatile oil, stir while adding, be uniformly mixed, after packing it is cooling obtain the paediatrics external application with antipyretic and antidote functions by
Rub ointment.
10. preparing the paediatrics external application massage ointment with antipyretic and antidote functions of the method preparation of ointment described in claim 6
Application in massage therapy, when use, are directly used in human body, do not mount between drug and human body material and adhesive plaster.
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| CN112156147A (en) * | 2020-11-10 | 2021-01-01 | 湖南省卿和玖安中医药科技有限公司 | Detoxicating and anti-inflammatory ointment |
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