CN109395050A - Paediatrics external application massage the ointment formula, preparation method and application for treating diarrhea - Google Patents
Paediatrics external application massage the ointment formula, preparation method and application for treating diarrhea Download PDFInfo
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- 239000002674 ointment Substances 0.000 title claims abstract description 55
- 206010012735 Diarrhoea Diseases 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 114
- 239000003921 oil Substances 0.000 claims abstract description 62
- 239000011159 matrix material Substances 0.000 claims abstract description 47
- 239000000341 volatile oil Substances 0.000 claims abstract description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000008367 deionised water Substances 0.000 claims abstract description 21
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 21
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 14
- 235000008397 ginger Nutrition 0.000 claims abstract description 14
- 239000000463 material Substances 0.000 claims abstract description 14
- 240000004510 Agastache rugosa Species 0.000 claims abstract description 13
- 235000008671 Calycanthus floridus Nutrition 0.000 claims abstract description 13
- 235000008670 Calycanthus occidentalis Nutrition 0.000 claims abstract description 13
- 241000628997 Flos Species 0.000 claims abstract description 13
- 235000004204 Foeniculum vulgare Nutrition 0.000 claims abstract description 13
- 244000148992 Lindera benzoin Species 0.000 claims abstract description 13
- 235000004520 Lindera benzoin Nutrition 0.000 claims abstract description 13
- 235000008262 Lindera benzoin var. benzoin Nutrition 0.000 claims abstract description 13
- 241000132012 Atractylodes Species 0.000 claims abstract description 11
- 241001078983 Tetradium ruticarpum Species 0.000 claims abstract description 11
- 240000006927 Foeniculum vulgare Species 0.000 claims abstract 3
- 244000273928 Zingiber officinale Species 0.000 claims abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 81
- 235000021355 Stearic acid Nutrition 0.000 claims description 30
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 30
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 30
- 239000008117 stearic acid Substances 0.000 claims description 30
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 18
- 239000000706 filtrate Substances 0.000 claims description 18
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 18
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- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 16
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- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 16
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims description 15
- 238000001816 cooling Methods 0.000 claims description 14
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- 238000000605 extraction Methods 0.000 claims description 9
- YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims description 9
- SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims description 9
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 9
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 9
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- 239000011505 plaster Substances 0.000 claims description 8
- 239000004328 sodium tetraborate Substances 0.000 claims description 8
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 8
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 6
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 6
- 239000004615 ingredient Substances 0.000 claims description 6
- 238000004064 recycling Methods 0.000 claims description 6
- 235000010199 sorbic acid Nutrition 0.000 claims description 6
- 239000004334 sorbic acid Substances 0.000 claims description 6
- 229940075582 sorbic acid Drugs 0.000 claims description 6
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- 210000001015 abdomen Anatomy 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- -1 hydrogen Potassium oxide Chemical class 0.000 claims description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 3
- 239000002253 acid Substances 0.000 claims description 3
- 230000006837 decompression Effects 0.000 claims description 3
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 3
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- 239000001257 hydrogen Substances 0.000 claims 1
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 3
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- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/235—Foeniculum (fennel)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
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- A—HUMAN NECESSITIES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/754—Evodia
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/55—Liquid-liquid separation; Phase separation
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- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Medical Informatics (AREA)
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- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of paediatrics external applications for treating diarrhea to massage ointment formula, the Chinese medicine material including following parts by weight: 1~5 parts by weight of fried atractylodes, 1~4 parts by weight of cortex cinnamomi, 1~6 parts by weight of wrinkled giant hyssop, 1~4 parts by weight of fennel seeds, 0.1~2 parts by weight of the root of three-nerved spicebush, 1~4 parts by weight of 1~4 parts by weight of ginger, 1~4 parts by weight of flos caryophylli and evodia rutaecarpa；It further include having matrix and deionized water.The invention also discloses the preparation methods of the paediatrics external application massage ointment for the treatment of diarrhea, and first step is to prepare traditional medicine volatile oil using medicine group；Second step is to prepare Chinese medicine extract；Third step is that the oil phase part of matrix point is added in traditional medicine volatile oil after mixing, and four steps is the paediatrics external application massage ointment that treatment diarrhea is made.The paediatrics external application massage ointment transdermal characteristic for the treatment of diarrhea of the invention is good, heightens the effect of a treatment, does not have foreign body sensation in use, being not easy pollution clothes and without matching while using.Preparation method preparation efficiency of the invention and yields are higher.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, and in particular to it is a kind of treat diarrhea paediatrics external application massage ointment and its
Using.
Background technique
Currently, the treatment method that the room of controlling mainly uses outside paediatrics has acupuncture, massage and external-applied ointment etc..Outside Chinese medicine
Therapy is because curative for effect, and without taking medicine, toxic side effect is small, deep to be favored by patient.Wherein external-applied ointment be all by drug crush with
Afterwards, Auxiliary Liquid Material such as ginger juice or vinegar is added and is tuned into paste, be pasted at acupuncture point.Although this drug usage mode curative effect is true
It cuts, but shows big, thick, the black feature of Chinese medicine fully.Its disadvantage mainly has: (1) medicament appearance is poor, skin clothing easy to pollute；(2) medicine
Object transdermal characteristic is poor, and mechanism of action is indefinite；(3) it is sticked using adhesive plaster, the easy allergy of part infant；(4) there is foreign body sensation after sticking, suffer from
Youngster's compliance is poor；(5) need to be ready-to-use, it is not easy to store.
In addition, paediatrics massage is mostly used talcum powder as lubricant now, in order to avoid damage skin.But Chinese medicine thinks, talcum
Mealiness is cold, has the effect of inducing diuresis for treating strangurtia, clearing away summerheat, clearing damp sore；For affection of exogenous wind-cold, disease caused by internal injury is raw and cold is simultaneously
It is improper, therefore this makes talcum powder not have blanket property as the method for lubricant.
Summary of the invention
The purpose of the present invention is to provide a kind of paediatrics external applications for treating diarrhea to massage ointment formula, treatment diarrhea obtained
Paediatrics external application massage ointment transdermal characteristic it is good, heighten the effect of a treatment, there is no foreign body sensation in use, being not easy pollution clothes and need not be current existing
Match, there are obvious curative effects to treatment baby diarrhea.
To achieve the above object, the paediatrics external application massage ointment formula for the treatment of diarrhea of the invention includes following parts by weight
Chinese medicine material: 1~5 parts by weight of fried atractylodes, 1~4 parts by weight of cortex cinnamomi, 1~6 parts by weight of wrinkled giant hyssop, 1~4 parts by weight of fennel seeds, the root of three-nerved spicebush
0.1~2 parts by weight, 1~4 parts by weight of 1~4 parts by weight of ginger, 1~4 parts by weight of flos caryophylli and evodia rutaecarpa；Fried atractylodes, cortex cinnamomi,
Wrinkled giant hyssop, fennel seeds, the root of three-nerved spicebush, ginger, flos caryophylli and evodia rutaecarpa form medicine group.
It further include having matrix and deionized water in addition to medicine group；The weight proportion of medicine group, deionized water and matrix are as follows:
10 ± 5 parts by weight of medicine group, 60 ± 5 parts by weight of deionized water, 10 ± 5 parts of matrix.
The matrix includes oil phase part point and aqueous portion, and oil phase part point includes stearic acid, atoleine and solid paraffin；
Aqueous portion includes borax, glycerol, triethanolamine and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of atoleine, solid paraffin 17
~19 parts by weight；0.1~0.5 parts by weight of borax, 3.0~5.0 parts by weight of glycerol, 0. 1~0.3 parts by weight of triethanolamine, Buddhist nun
Moor 0.2~0.5 parts by weight of golden ethyl ester.
The matrix includes oil phase part point and aqueous portion, and oil phase part point includes stearic acid, glycerol monostearate and Bai Fan
Intellectual circle；Aqueous portion includes potassium hydroxide, glycerol and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of glycerol monostearate, Bai Fanshi
17~19 parts by weight of woods；0.1~0.5 parts by weight of potassium hydroxide, 3.0~5.0 parts by weight of glycerol, ethylparaben 0.2~0.5
Parts by weight.
The matrix includes oil phase part point and aqueous portion, and oil phase part point includes stearic acid, stearyl alcohol, albolene and liquid
Body paraffin；Aqueous portion includes Tween-80, Arlacel-60, glycerol and sorbic acid；
The weight proportion of each component are as follows:
17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of stearyl alcohol, 17~19 parts by weight of albolene, atoleine 2~
4 parts by weight；Tween-80 is 3.0~5.0 parts by weight, and Arlacel-60 is 0.1~0.5 parts by weight, and glycerol is 8~12 parts by weight, mountain
Pears acid is 0.2~0.5 parts by weight.
The invention also discloses the preparation methods of the paediatrics external application massage ointment for the treatment of diarrhea, utilize above-mentioned treatment diarrhea
Paediatrics external application is massaged ointment formula and is carried out, and sequentially includes the following steps:
First step is to prepare traditional medicine volatile oil using medicine group；
First step is specifically that each component of medicine group is added in the container with volume instruction, and 8 times of drugs are then added
The water of the total volume of group each component, is volatilized oil 4 hours using extraction by steam distillation, and it is spare to collect traditional medicine volatile oil；
Second step is to prepare Chinese medicine extract；
Second step specifically includes four sub-steps:
First sub-step is to filter the decocting liquid that volatilization oil was extracted in first step, obtains two parts substance, a part
For the dregs of a decoction, another part is the first residual filtrate；
Second sub-step is that the dregs of a decoction for obtaining the first sub-step are put into the container with volume instruction, and 6 times of dregs of a decoction are added
The water of volume continue using extraction by steam distillation volatilize oil 1 hour, by the traditional medicine volatile oil extracted in this sub-step with
Traditional medicine volatile oil made from first step is mixed and is kept the temperature at 80 DEG C spare；
Third sub-step is that the decocting liquid filtration of 1 hour volatilization oil will be extracted in the second sub-step, discards the dregs of a decoction, obtains the
Two residual filtrates；First residual filtrate and the second residual filtrate are merged into total surplus filtrate；
4th sub-step is to be concentrated into total surplus filtrate decompression to reach 1.1~1.15 to the relative density of water, is then added 95%
The volume content of ethanol water to ethyl alcohol reaches (75 ± 1) %, stirs evenly, after standing 24 hours, recycling supernatant to supernatant
The supernatant of recycling is concentrated into without ethanol flavor and reaches 1.1 ± 0.05 to the relative density of water, obtain Chinese medicine extract by liquid；
Third step is the mixed Chinese medicine of the second sub-step that the oil phase part of matrix point is added to second step after mixing
In volatile oil, the traditional medicine volatile oil containing oil phase part point is obtained, is kept the temperature at 80 DEG C spare；
Four steps is the traditional Chinese medicine extraction prepared in whole or most of components and second step in the aqueous portion by matrix
Liquid is added in deionized water, is added in the third step traditional medicine volatile oil obtained containing oil phase part point after being completely dissolved, mixing
The cooling paediatrics external application massage ointment for obtaining treatment diarrhea after uniformly.
Third step is specifically:
The oil phase part of matrix point is stirred after stearic acid, atoleine and solid paraffin are mixed and heated to 150 DEG C, stearic acid is made
It is dissolved in paraffin and is uniformly mixed；80 DEG C are subsequently cooled to, the mixed Chinese medicine of the second sub-step that second step is added is waved
In hair oil, and the ethylparaben in the aqueous portion of matrix is added, is kept the temperature at 80 DEG C spare；
Four steps is specifically:
By remaining ingredient, that is, borax of Chinese medicine extract obtained in the 4th sub-step of second step and the aqueous portion of matrix,
Glycerol and triethanolamine are added in deionized water, are heated to dissolving at 80 DEG C, are added made from third step until completely dissolved
It in traditional medicine volatile oil containing oil phase part point, stirs while adding, is uniformly mixed, the cooling youngster for obtaining treatment diarrhea after packing
Ointment is massaged in section's external application.
Third step is specifically:
By the ethylparaben in the oil phase part of matrix point i.e. stearic acid, glycerol monostearate and albolene and aqueous portion
Stirring and dissolving after being mixed and heated to 100 DEG C is cooled to 80 DEG C after mixing, after the second sub-step mixing of second step is added
Traditional medicine volatile oil in, kept the temperature at 80 DEG C spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and remaining ingredient, that is, hydrogen-oxygen of the aqueous portion of matrix
Change potassium and glycerol is added in deionized water, be heated to dissolving at 80 DEG C, is added made from third step and contains until completely dissolved
It in 80 DEG C of traditional medicine volatile oil of oil phase part point, stirs while adding, is uniformly mixed, cooling obtain treats diarrhea after packing
Ointment is massaged in paediatrics external application.
Third step is specifically:
The oil phase part of matrix point i.e. stearic acid, stearyl alcohol, albolene and atoleine is mixed and heated to after 150 DEG C stir it is molten
Solution, is cooled to 80 DEG C after mixing, is added in the mixed traditional medicine volatile oil of the second sub-step of second step, at 80 DEG C
It keeps the temperature spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and aqueous portion, that is, Tween-80, the sapn-of matrix
60, glycerol and sorbic acid are added in deionized water, are heated to dissolving at 80 DEG C, are added made from third step until completely dissolved
It in 80 DEG C of the traditional medicine volatile oil containing oil phase part point, stirs while adding, is uniformly mixed, cooling obtains treatment abdomen after packing
The paediatrics external application massage ointment rushed down.
The invention also discloses the paediatrics external application for the treatment of diarrhea obtained by above-mentioned preparation method massage ointment to control in massage
Application in treatment, when use, are directly used in human body, do not mount between drug and human body material and adhesive plaster.
The paediatrics external application massage ointment smooth appearance for the treatment of diarrhea produced by the present invention is fine and smooth, is not easy pollution clothes；Treatment
The paediatrics external application massage ointment of diarrhea is emulsion, and transdermal characteristic is good, plays a role conducive to drug to human body, is had to baby diarrhea bright
Aobvious curative effect.
Treat diarrhea paediatrics external application massage ointment using when do not need mount material and adhesive plaster, can directly use, keep away
Exempt from adhesive plaster etc. to mount the stimulation of materials on skin.In contrast, the drug and profit used when paediatrics in the prior art is massaged
Lubrication prescription is easy pollution clothes and human body, not easy to clean, thus needed when use between drug and human body setting mount material and
Adhesive plaster not can avoid the stimulation of material and adhesive plaster to skin of mounting.
When use after massage rubbing, medicaments uniformity is coated with skin, and without foreign body sensation, children compared with the past are easier to connect
It is treated；The paediatrics external application massage ointment for the treatment of diarrhea made of of the invention has facilitation for the absorption of drug, and adopts
It is compared with other lubricants, hence it is evident that improve cure rate.
It is convenient that the paediatrics external application massage ointment of manufactured treatment diarrhea of the invention is used, carries and stored, without current
Now match, greatly facilitate use, be suitable for popularization and application, and saved the extemporaneous preparation time, hence it is evident that improves massage therapy
Efficiency had both saved the waiting time of patient, allows hospital to accept more patients for medical treatment within the unit time, also improves hospital
Profitability.
The paediatrics external application massage ointment for the treatment of diarrhea of the invention is made of using conventional Chinese medicine, and raw material is easy to get, safe nothing
Toxic side effect not only may be used by the paediatrics external application massage salve application of obtained treatment diarrhea in the massage agent of a variety of dosage forms
To play lubricating action, also has effects that certain warm navel analgesic, antidiarrheal, be suitble to promote and apply.Preparation method of the invention
Procedure arrangement is reasonable, provides effective way, preparation efficiency and non-defective unit for the paediatrics external application massage ointment of preparation treatment diarrhea
Rate is higher.
Specific embodiment
The invention discloses a kind of paediatrics external applications for treating diarrhea to massage ointment, the Chinese medicine material including following parts by weight:
1~5(of fried atractylodes includes endpoints thereof, similarly hereinafter) parts by weight, 1~4 parts by weight of cortex cinnamomi, 1~6 parts by weight of wrinkled giant hyssop, 1~4 weight of fennel seeds
Measure part, 0.1~2 parts by weight of the root of three-nerved spicebush, 1~4 parts by weight of 1~4 parts by weight of ginger, 1~4 parts by weight of flos caryophylli and evodia rutaecarpa；It fries
Rhizoma atractylodis, cortex cinnamomi, wrinkled giant hyssop, fennel seeds, the root of three-nerved spicebush, ginger, flos caryophylli and evodia rutaecarpa form medicine group.
In addition to medicine group, the paediatrics external application massage ointment for treating diarrhea further includes having matrix and deionized water；Medicine group is gone
The weight proportion of ionized water and matrix are as follows: 10 ± 5 parts by weight of medicine group, 60 ± 5 parts by weight of deionized water, 10 ± 5 parts of matrix.
The invention also discloses the paediatrics external application of above-mentioned treatment diarrhea massage ointment preparation method, according to the following steps into
Row:
First step is to prepare traditional medicine volatile oil using medicine group；
First step is specifically that each component of medicine group is added in the container with volume instruction, and 8 times of drugs are then added
The water of the total volume of group each component, is volatilized oil 4 hours using extraction by steam distillation, and it is spare to collect traditional medicine volatile oil；
Second step is to prepare Chinese medicine extract；
Second step specifically includes four sub-steps:
First sub-step is to filter the decocting liquid that volatilization oil was extracted in first step, obtains two parts substance, a part
For the dregs of a decoction, another part is the first residual filtrate；
Second sub-step is that the dregs of a decoction for obtaining the first sub-step are put into the container with volume instruction, and 6 times of dregs of a decoction are added
The water of volume continue using extraction by steam distillation volatilize oil 1 hour, by the traditional medicine volatile oil extracted in this sub-step with
Traditional medicine volatile oil made from first step is mixed and is kept the temperature at 80 DEG C spare；
Third sub-step is that the decocting liquid filtration of 1 hour volatilization oil will be extracted in the second sub-step, discards the dregs of a decoction, obtains the
Two residual filtrates；First residual filtrate and the second residual filtrate are merged into total surplus filtrate；
4th sub-step is to be concentrated into total surplus filtrate decompression to reach the relative density of water to measure at 1.1~1.15(60 DEG C
Relative density), 95% ethanol water (i.e. the volume ratio of ethyl alcohol and water be 95:5 aqueous solution) is then slowly added into ethyl alcohol
Volume content reaches (75 ± 1) %, stirs evenly, and stands 24 hours.Protein, par-tial polysaccharide and tannin are insoluble in ethyl alcohol
Solution, other compositions are dissolved into ethyl alcohol and separate out with supernatant.Recycling supernatant is to supernatant without ethanol flavor (even if ethyl alcohol fills
Point evaporation), the supernatant of recycling is concentrated into reach the relative density of water measure relative density at 1.1 ± 0.05(60 DEG C),
Obtain Chinese medicine extract；It is good to remove ethyl alcohol effect for such mode.Equipment volume is also small, facilitates operation.
Third step is to divide the oil phase part of matrix the second sub-step that second step is added after mixing mixed
In traditional medicine volatile oil, the traditional medicine volatile oil (namely oil phase part containing traditional medicine volatile oil point) containing oil phase part point is obtained, 80 DEG C
Lower heat preservation is spare；
Four steps is the traditional Chinese medicine extraction prepared in whole or most of components and second step in the aqueous portion by matrix
Liquid is added in deionized water, is slowly added in the third step traditional medicine volatile oil obtained containing oil phase part point after being completely dissolved,
The cooling paediatrics external application massage ointment for obtaining treatment diarrhea after mixing.
The invention also discloses application of the paediatrics external application of the above-mentioned treatment diarrhea massage ointment in massage therapy, when use
It is directly used in human body, do not mount between drug and human body material and adhesive plaster.
Embodiment one
Treat the Chinese medicine material including following parts by weight in the paediatrics external application massage ointment of diarrhea: 1 parts by weight of fried atractylodes, cortex cinnamomi 2
Parts by weight, 2 parts by weight of wrinkled giant hyssop, 2 parts by weight of fennel seeds, 0.3 parts by weight of the root of three-nerved spicebush, 2 parts by weight of ginger, 2 parts by weight of flos caryophylli and
2 parts by weight of evodia rutaecarpa；Fried atractylodes, cortex cinnamomi, wrinkled giant hyssop, fennel seeds, the root of three-nerved spicebush, ginger, flos caryophylli and evodia rutaecarpa form medicine group.
It treats in the paediatrics external application massage ointment of diarrhea, the matrix includes oil phase part point and aqueous portion, oil phase part point
Including stearic acid, atoleine and solid paraffin；Aqueous portion includes borax, glycerol, triethanolamine and ethylparaben；
The weight proportion of each component are as follows: 17 parts by weight of stearic acid, 1.0 parts by weight of atoleine, 17 parts by weight of solid paraffin；Boron
0.1 parts by weight of sand, 3.0 parts by weight of glycerol, 0. 1 parts by weight of triethanolamine, 0.4 parts by weight of ethylparaben.
The third step of preparation method is specifically:
The oil phase part of matrix point is stirred after stearic acid, atoleine and solid paraffin are mixed and heated to 150 DEG C, stearic acid is made
It is dissolved in paraffin and is uniformly mixed；80 DEG C are subsequently cooled to, the mixed Chinese medicine of the second sub-step that second step is added is waved
In hair oil, and the ethylparaben in the aqueous portion of matrix is added, is kept the temperature at 80 DEG C spare；
The four steps of preparation method is specifically:
By remaining ingredient, that is, borax of Chinese medicine extract obtained in the 4th sub-step of second step and the aqueous portion of matrix,
Glycerol and triethanolamine are added in deionized water, are heated to dissolving at 80 DEG C, are slowly added to third step system until completely dissolved
It in the traditional medicine volatile oil containing oil phase part point obtained, stirs while adding, is uniformly mixed, cooling obtains treatment diarrhea after packing
Paediatrics external application massage ointment.
Packing is for the ease of storage, transport and using the paediatrics external application massage ointment for the treatment of diarrhea.It is difficult to dispense after cooling
Degree increases, therefore should be dispensed before cooling.
Embodiment two
The paediatrics external application massage ointment for treating diarrhea includes the Chinese medicine material of following parts by weight: 5 parts by weight of fried atractylodes, 4 weight of cortex cinnamomi
Measure part, 6 parts by weight of wrinkled giant hyssop, 4 parts by weight of fennel seeds, 2 parts by weight of the root of three-nerved spicebush, 4 parts by weight of ginger, 4 parts by weight of flos caryophylli and Wu Zhu
3 parts by weight of cornel；Fried atractylodes, cortex cinnamomi, wrinkled giant hyssop, fennel seeds, the root of three-nerved spicebush, ginger, flos caryophylli and evodia rutaecarpa form medicine group.
It treats in the paediatrics external application massage ointment of diarrhea, the matrix includes oil phase part point and aqueous portion, oil phase part point
Including stearic acid, glycerol monostearate and albolene；Aqueous portion includes potassium hydroxide, glycerol and ethylparaben；
The weight proportion of each component are as follows: 19 parts by weight of stearic acid, 3.0 parts by weight of glycerol monostearate, 19 weight of albolene
Part；0.5 parts by weight of potassium hydroxide, 5.0 parts by weight of glycerol, 0.5 parts by weight of ethylparaben.
The third step of preparation method is specifically: by the oil phase part of matrix point i.e. stearic acid, glycerol monostearate and Bai Fan
Stirring and dissolving after ethylparaben in intellectual circle and aqueous portion is mixed and heated to 100 DEG C, is cooled to 80 DEG C after mixing,
It is added in the mixed traditional medicine volatile oil of the second sub-step of second step, is kept the temperature at 80 DEG C spare；
The four steps of preparation method is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and remaining ingredient, that is, hydrogen-oxygen of the aqueous portion of matrix
Change potassium and glycerol is added in deionized water, is heated to dissolving at 80 DEG C, be slowly added to made from third step until completely dissolved
It in 80 DEG C of the traditional medicine volatile oil containing oil phase part point, stirs while adding, is uniformly mixed, cooling obtains treatment abdomen after packing
The paediatrics external application massage ointment rushed down.
Embodiment three
The paediatrics external application massage ointment for treating diarrhea includes the Chinese medicine material of following parts by weight: 3 parts by weight of fried atractylodes, 3 weight of cortex cinnamomi
Measure part, 4 parts by weight of wrinkled giant hyssop, 3 parts by weight of fennel seeds, 1 parts by weight of the root of three-nerved spicebush, 3 parts by weight of ginger, 2 parts by weight of flos caryophylli and Wu Zhu
4 parts by weight of cornel；Fried atractylodes, cortex cinnamomi, wrinkled giant hyssop, fennel seeds, the root of three-nerved spicebush, ginger, flos caryophylli and evodia rutaecarpa form medicine group.
It treats in the paediatrics external application massage ointment of diarrhea, the matrix includes oil phase part point and aqueous portion, oil phase part point
Including stearic acid, stearyl alcohol, albolene and atoleine；Aqueous portion includes Tween-80, Arlacel-60, glycerol and sorb
Acid；
The weight proportion of each component are as follows:
17~19 parts by weight of stearic acid, 2 parts by weight of stearyl alcohol (octadecyl alcolol), 18 parts by weight of albolene, 3 weight of atoleine
Part；Tween-80 is 4 parts by weight, and Arlacel-60 is 0.3 parts by weight, and glycerol is 10 parts by weight, and sorbic acid is 0.4 parts by weight.
The third step of preparation method is specifically:
I.e. stearic acid, stearyl alcohol (octadecyl alcolol), albolene and the atoleine of the oil phase part of matrix point is mixed and heated to 150 DEG C
Stirring and dissolving afterwards is cooled to 80 DEG C after mixing, is added in the mixed traditional medicine volatile oil of the second sub-step of second step,
It is kept the temperature at 80 DEG C spare；
The four steps of preparation method is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and aqueous portion, that is, Tween-80, the sapn-of matrix
60, glycerol and sorbic acid are added in deionized water, are heated to dissolving at 80 DEG C, are slowly added to third step system until completely dissolved
It in 80 DEG C of the traditional medicine volatile oil containing oil phase part point obtained, stirs while adding, is uniformly mixed, cooling obtain is controlled after packing
Ointment is massaged in the paediatrics external application for treating diarrhea.
Clinical observation on the therapeutic effect
Diagnostic criteria: diagnostic criteria is referring to " new Chinese medicine guideline of clinical investigations ".
Be included in standard: (1) meeting baby diarrhea standard person, and tcm diagnosis card belong to wind-cold type (diarrhea is thin, more foams,
Not very, borborygmus abdominal pain, tongue fur is thin white for foul smell, and some is with fever, and clear nasal discharge of having a stuffy nose, floating and tense pulse or fingerprint are red)；(2) age was at 6 months
~6 years old persons；(3) be ready it is tested, and by parent sign informed consent form person；(4) without enteron aisle makings venereal disease change person.
Exclusion criteria: (1) severe malnutrition person；(2) with other systemic disease persons；(3) cholera, all kinds of dysentery
Person.
Observation method: treatment group, the paediatrics external application massage ointment of the treatment diarrhea prepared using embodiment three is as lubrication
Agent is treated using gimmick and medicinal massage.Control group, using talcum powder as lubricant, using gimmick identical with treatment group
It is treated with identical medicinal massage.Continuous treatment 3 days, once a day.Other medicines are not used during treatment, have been careful in one's diet
It occupies.
Curative effect determinate standard: referring to Ministry of Health of the People's Republic of China 2002 formulate " new Chinese medicine clinical research refers to
Lead principle " it formulates.Clinical cure (recovery from illness): times of defecation, stool, symptom and sign are restored normally completely, abnormal physical and chemical
Index restores normal；Effective: times of defecation significantly reduces and (reduces 1/3 or less to before treating), and character improves, symptom, body
Sign and abnormal physical and chemical index are obviously improved；Effective: times of defecation reduces 1/2 to treatment hereinafter, character improvement, symptom, body
Sign and abnormal physical and chemical index make moderate progress；It is invalid: not meet the above standard person.
Treatment results: treatment group enters group 31, and control group enters group 30, two groups totally 61.After treatment 3 days, treatment group fullys recover from an illness
More 22, effective 8, invalid 1；Control group is fully recovered 15, effective 9, invalid 6.Compare statistics Chi-square Test.As a result
It see the table below.
Note: P value is for determining hypothesis testing result parameter, the exactly obtained sample when null hypothesis is true
Observe the probability that result or more extreme result occur.P value is smaller, shows that result is more significant.P value is less than 0.05 or less than 0.01
Show statistically significant.
Treatment results are through chi-square criterion, and cure rate and control group no significant difference (P > 0.05) for the treatment of group, treatment group always has
Efficiency and control group have notable difference (P < 0.05), and treatment group's therapeutic effect is better than control group.
The above embodiments are only used to illustrate and not limit the technical solutions of the present invention, although referring to above-described embodiment to this hair
It is bright to be described in detail, those skilled in the art should understand that: still the present invention can be modified or be waited
With replacement, without departing from the spirit or scope of the invention, or any substitutions, should all cover in power of the invention
In sharp claimed range.
Claims (10)
1. ointment formula is massaged in the paediatrics external application for treating diarrhea, it is characterised in that the Chinese medicine material including following parts by weight: frying grey
1~5 parts by weight of art, 1~4 parts by weight of cortex cinnamomi, 1~6 parts by weight of wrinkled giant hyssop, 1~4 parts by weight of fennel seeds, 0.1~2 parts by weight of the root of three-nerved spicebush,
1~4 parts by weight of 1~4 parts by weight of ginger, 1~4 parts by weight of flos caryophylli and evodia rutaecarpa；Fried atractylodes, cortex cinnamomi, wrinkled giant hyssop, fennel seeds,
The root of three-nerved spicebush, ginger, flos caryophylli and evodia rutaecarpa form medicine group.
2. ointment formula is massaged in the paediatrics external application for the treatment of diarrhea according to claim 1, it is characterised in that: remove medicine group
It outside, further include having matrix and deionized water；The weight proportion of medicine group, deionized water and matrix are as follows: 10 ± 5 weight of medicine group
Part, 60 ± 5 parts by weight of deionized water, 10 ± 5 parts of matrix.
3. ointment formula is massaged in the paediatrics external application for the treatment of diarrhea according to claim 2, it is characterised in that: the matrix packet
Oil phase part point and aqueous portion are included, oil phase part point includes stearic acid, atoleine and solid paraffin；Aqueous portion include borax,
Glycerol, triethanolamine and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of atoleine, solid paraffin 17
~19 parts by weight；0.1~0.5 parts by weight of borax, 3.0~5.0 parts by weight of glycerol, 0. 1~0.3 parts by weight of triethanolamine, Buddhist nun
Moor 0.2~0.5 parts by weight of golden ethyl ester.
4. ointment formula is massaged in the paediatrics external application for the treatment of diarrhea according to claim 2, it is characterised in that: the matrix packet
Oil phase part point and aqueous portion are included, oil phase part point includes stearic acid, glycerol monostearate and albolene；Aqueous portion includes hydrogen
Potassium oxide, glycerol and ethylparaben；
The weight proportion of each component are as follows: 17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of glycerol monostearate, Bai Fanshi
17~19 parts by weight of woods；0.1~0.5 parts by weight of potassium hydroxide, 3.0~5.0 parts by weight of glycerol, ethylparaben 0.2~0.5
Parts by weight.
5. ointment formula is massaged in the paediatrics external application for the treatment of diarrhea according to claim 2, it is characterised in that: the matrix packet
Oil phase part point and aqueous portion are included, oil phase part point includes stearic acid, stearyl alcohol, albolene and atoleine；Aqueous portion packet
Include Tween-80, Arlacel-60, glycerol and sorbic acid；
The weight proportion of each component are as follows:
17~19 parts by weight of stearic acid, 1.0~3.0 parts by weight of stearyl alcohol, 17~19 parts by weight of albolene, atoleine 2~
4 parts by weight；Tween-80 is 3.0~5.0 parts by weight, and Arlacel-60 is 0.1~0.5 parts by weight, and glycerol is 8~12 parts by weight, mountain
Pears acid is 0.2~0.5 parts by weight.
6. treating the preparation method of the paediatrics external application massage ointment of diarrhea, abdomen is treated using described in any one of claim 3-5
The paediatrics external application massage ointment formula rushed down carries out, it is characterised in that sequentially includes the following steps:
First step is to prepare traditional medicine volatile oil using medicine group；
First step is specifically that each component of medicine group is added in the container with volume instruction, and 8 times of drugs are then added
The water of the total volume of group each component, is volatilized oil 4 hours using extraction by steam distillation, and it is spare to collect traditional medicine volatile oil；
Second step is to prepare Chinese medicine extract；
Second step specifically includes four sub-steps:
First sub-step is to filter the decocting liquid that volatilization oil was extracted in first step, obtains two parts substance, a part
For the dregs of a decoction, another part is the first residual filtrate；
Second sub-step is that the dregs of a decoction for obtaining the first sub-step are put into the container with volume instruction, and 6 times of dregs of a decoction are added
The water of volume continue using extraction by steam distillation volatilize oil 1 hour, by the traditional medicine volatile oil extracted in this sub-step with
Traditional medicine volatile oil made from first step is mixed and is kept the temperature at 80 DEG C spare；
Third sub-step is that the decocting liquid filtration of 1 hour volatilization oil will be extracted in the second sub-step, discards the dregs of a decoction, obtains the
Two residual filtrates；First residual filtrate and the second residual filtrate are merged into total surplus filtrate；
4th sub-step is to be concentrated into total surplus filtrate decompression to reach 1.1~1.15 to the relative density of water, is then added 95%
The volume content of ethanol water to ethyl alcohol reaches (75 ± 1) %, stirs evenly, after standing 24 hours, recycling supernatant to supernatant
The supernatant of recycling is concentrated into without ethanol flavor and reaches 1.1 ± 0.05 to the relative density of water, obtain Chinese medicine extract by liquid；
Third step is the mixed Chinese medicine of the second sub-step that the oil phase part of matrix point is added to second step after mixing
In volatile oil, the traditional medicine volatile oil containing oil phase part point is obtained, is kept the temperature at 80 DEG C spare；
Four steps is the traditional Chinese medicine extraction prepared in whole or most of components and second step in the aqueous portion by matrix
Liquid is added in deionized water, is added in the third step traditional medicine volatile oil obtained containing oil phase part point after being completely dissolved, mixing
The cooling paediatrics external application massage ointment for obtaining treatment diarrhea after uniformly.
7. preparation method according to claim 6, it is characterised in that: third step is specifically:
The oil phase part of matrix point is stirred after stearic acid, atoleine and solid paraffin are mixed and heated to 150 DEG C, stearic acid is made
It is dissolved in paraffin and is uniformly mixed；80 DEG C are subsequently cooled to, the mixed Chinese medicine of the second sub-step that second step is added is waved
In hair oil, and the ethylparaben in the aqueous portion of matrix is added, is kept the temperature at 80 DEG C spare；
Four steps is specifically:
By remaining ingredient, that is, borax of Chinese medicine extract obtained in the 4th sub-step of second step and the aqueous portion of matrix,
Glycerol and triethanolamine are added in deionized water, are heated to dissolving at 80 DEG C, are added made from third step until completely dissolved
It in traditional medicine volatile oil containing oil phase part point, stirs while adding, is uniformly mixed, the cooling youngster for obtaining treatment diarrhea after packing
Ointment is massaged in section's external application.
8. preparation method according to claim 6, it is characterised in that: third step is specifically:
By the ethylparaben in the oil phase part of matrix point i.e. stearic acid, glycerol monostearate and albolene and aqueous portion
Stirring and dissolving after being mixed and heated to 100 DEG C is cooled to 80 DEG C after mixing, after the second sub-step mixing of second step is added
Traditional medicine volatile oil in, kept the temperature at 80 DEG C spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and remaining ingredient, that is, hydrogen-oxygen of the aqueous portion of matrix
Change potassium and glycerol is added in deionized water, be heated to dissolving at 80 DEG C, is added made from third step and contains until completely dissolved
It in 80 DEG C of traditional medicine volatile oil of oil phase part point, stirs while adding, is uniformly mixed, cooling obtain treats diarrhea after packing
Ointment is massaged in paediatrics external application.
9. preparation method according to claim 6, it is characterised in that: third step is specifically:
The oil phase part of matrix point i.e. stearic acid, stearyl alcohol, albolene and atoleine is mixed and heated to after 150 DEG C stir it is molten
Solution, is cooled to 80 DEG C after mixing, is added in the mixed traditional medicine volatile oil of the second sub-step of second step, at 80 DEG C
It keeps the temperature spare；
Four steps is specifically:
By Chinese medicine extract obtained in the 4th sub-step of second step and aqueous portion, that is, Tween-80, the sapn-of matrix
60, glycerol and sorbic acid are added in deionized water, are heated to dissolving at 80 DEG C, are added made from third step until completely dissolved
It in 80 DEG C of the traditional medicine volatile oil containing oil phase part point, stirs while adding, is uniformly mixed, cooling obtains treatment abdomen after packing
The paediatrics external application massage ointment rushed down.
10. the paediatrics external application massage ointment for the treatment of diarrhea obtained by preparation method described in claim 6 is in massage therapy
It is directly used in human body when using, use, do not mount between drug and human body material and adhesive plaster.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111939205A (en) * | 2020-08-13 | 2020-11-17 | 国人健康管理(杭州)有限公司 | Medicinal moxibustion for acute diarrhea and preparation method thereof |
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Application publication date: 20190301 |