CN114344185A - Oil-in-water skin care emulsion containing sialylate and preparation method thereof - Google Patents
Oil-in-water skin care emulsion containing sialylate and preparation method thereof Download PDFInfo
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- CN114344185A CN114344185A CN202111501671.2A CN202111501671A CN114344185A CN 114344185 A CN114344185 A CN 114344185A CN 202111501671 A CN202111501671 A CN 202111501671A CN 114344185 A CN114344185 A CN 114344185A
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- oil
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- water
- sialylate
- care milk
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 68
- 239000000839 emulsion Substances 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title abstract description 13
- 235000013336 milk Nutrition 0.000 claims abstract description 36
- 210000004080 milk Anatomy 0.000 claims abstract description 36
- 239000008267 milk Substances 0.000 claims abstract description 31
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims abstract description 23
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 17
- 229960001631 carbomer Drugs 0.000 claims abstract description 17
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims abstract description 16
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 14
- 239000002562 thickening agent Substances 0.000 claims abstract description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical group CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 30
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical group CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 20
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical group [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 20
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical group NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 20
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 20
- 229920002401 polyacrylamide Polymers 0.000 claims description 12
- 239000004264 Petrolatum Substances 0.000 claims description 11
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 11
- 229940066842 petrolatum Drugs 0.000 claims description 11
- 235000019271 petrolatum Nutrition 0.000 claims description 11
- -1 polydimethylsiloxane Polymers 0.000 claims description 11
- AMUTYVGRCVFCCD-UHFFFAOYSA-N 5,6-diaminopyridine-3-carboxylic acid Chemical compound NC1=CC(C(O)=O)=CN=C1N AMUTYVGRCVFCCD-UHFFFAOYSA-N 0.000 claims description 10
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 10
- 229960000458 allantoin Drugs 0.000 claims description 10
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 10
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims description 10
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 10
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 10
- 229940032094 squalane Drugs 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 9
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 7
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- ICIDSZQHPUZUHC-UHFFFAOYSA-N 2-octadecoxyethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCO ICIDSZQHPUZUHC-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 230000001804 emulsifying effect Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 239000003755 preservative agent Substances 0.000 claims description 6
- 230000002335 preservative effect Effects 0.000 claims description 6
- 229940100458 steareth-21 Drugs 0.000 claims description 6
- 239000003974 emollient agent Substances 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- ILCOCZBHMDEIAI-UHFFFAOYSA-N 2-(2-octadecoxyethoxy)ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCO ILCOCZBHMDEIAI-UHFFFAOYSA-N 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 229940098760 steareth-2 Drugs 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 2
- 239000011575 calcium Substances 0.000 claims description 2
- 229910052791 calcium Inorganic materials 0.000 claims description 2
- 239000011777 magnesium Substances 0.000 claims description 2
- 229910052749 magnesium Inorganic materials 0.000 claims description 2
- 239000011591 potassium Substances 0.000 claims description 2
- 229910052700 potassium Inorganic materials 0.000 claims description 2
- 230000008439 repair process Effects 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000007764 o/w emulsion Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 abstract description 9
- 239000000126 substance Substances 0.000 abstract description 9
- 238000006731 degradation reaction Methods 0.000 abstract description 4
- 238000011160 research Methods 0.000 abstract description 3
- 230000015556 catabolic process Effects 0.000 abstract description 2
- 230000000052 comparative effect Effects 0.000 description 17
- 239000006071 cream Substances 0.000 description 7
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- 239000002994 raw material Substances 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 229940082500 cetostearyl alcohol Drugs 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 3
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 230000002349 favourable effect Effects 0.000 description 2
- 230000016615 flocculation Effects 0.000 description 2
- 238000005189 flocculation Methods 0.000 description 2
- 229940075529 glyceryl stearate Drugs 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 230000002906 microbiologic effect Effects 0.000 description 2
- 229940100460 peg-100 stearate Drugs 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- SQVRNKJHWKZAKO-PFQGKNLYSA-N N-acetyl-beta-neuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-PFQGKNLYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000004641 brain development Effects 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 238000002845 discoloration Methods 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000002337 glycosamines Chemical class 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 150000003214 pyranose derivatives Chemical group 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 238000013517 stratification Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229940100611 topical cream Drugs 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention provides an oil-in-water skin care emulsion containing a sialylate and a preparation method thereof. The present invention applies a sialylate to an oil-in-water system to solve the problem of degradation of sialic acid and the problem of reduced viscosity of thickeners, especially carbomer-containing thickeners. According to the invention, through a large amount of researches on the emulsifier and the thickener of the skin care milk, the sialylate can stably exist in the obtained oil-in-water system, and the obtained skin care milk has excellent physical and chemical stability and remarkably improves the quality of cosmetics.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to an oil-in-water skin care emulsion containing a sialylate and a preparation method thereof.
Background
Sialic acid (Sialic acid) is an acidic amino sugar containing 9 carbon atoms and having a pyranose structure, also known as N-acetylneuraminic acid, cubilose acid and cubilose element, widely exists in various biological tissues, is an important part forming a cell surface complex carbohydrate, and has physiological effects of promoting brain development, improving memory, resisting inflammation, viruses and tumors, improving the absorption of vitamins and minerals by intestinal tracts and the like. With the intensive research and understanding of sialic acid, sialic acid also inhibits the oxidation of tyrosine, reduces melanin deposition and thus improves the appearance of skin. Therefore, sialic acid can be widely used in the cosmetic field.
The oil-in-water (O/W) system is one of the most commonly used emulsification systems for topical cream emulsions, and is an emulsification system in which an oil is dispersed in water, the oil being the internal phase and the water being the continuous external phase. The oil-in-water system has the advantages of simple operation, fresh skin feeling and the like, and is the most common preparation formulation of cosmetics.
However, the applicant finds that when sialic acid is applied to an oil-in-water system, the thickening body (particularly the thickening body containing carbomer) has the problems of gravity stratification, particle flocculation and agglomeration when the thickening body is matched with partial auxiliary materials, and also finds that the sialic acid is subjected to degradation reaction in the oil-in-water system, so that the content of the sialic acid in the system is reduced, and meanwhile, the generated by-products cause the problem of discoloration of the system, and the quality of a cosmetic product is seriously reduced.
In view of this, the invention is particularly proposed.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide an oil-in-water type skin care milk containing a sialylate, which has excellent physical and chemical stability and remarkably improves the quality of cosmetics. The invention also provides a preparation method of the oil-in-water skin care emulsion containing the sialic acid salt.
In order to achieve the above object, the first aspect of the present invention provides an oil-in-water skin care emulsion containing a sialylate, wherein the sialylate is used as the only functional ingredient or one of the functional ingredients.
The invention discovers that the sialic acid salt formed by neutralizing sialic acid with alkali has obviously improved stability to acid, heat, light and the like, and when the sialic acid salt is added into an oil-in-water system as a unique functional component or one of the functional components, the problem that the sialic acid reduces the viscosity of a thickening body (particularly a thickening body containing carbomer) can be effectively solved, and the stability of the skin care milk is improved.
In some specific embodiments, the oil-in-water skin care milk includes a sialylate and an emulsifier.
Further, the weight percentage content of the sialic acid salt in the oil-in-water skin care milk is 0.1-2%; the weight percentage of the emulsifier in the oil-in-water skin care milk is 4-13%.
In some particular embodiments, the sialylate is selected from one or more of sodium sialylate, potassium sialylate, calcium sialylate, magnesium sialylate.
Further, the emulsifier comprises the following components in a weight ratio of (2-5): (1-5): steareth-21, steareth-2 and cetearyl alcohol of (1-3). The invention further discovers that the skin care emulsion adopting the emulsifier has no layering phenomenon, is more favorable for improving the physical stability of a system, and simultaneously has stable sialylate, is not easy to generate degradation reaction, and is further more favorable for improving the chemical stability of the system.
In some specific embodiments, the oil-in-water skin care emulsion further comprises 0.15-6 wt% of a thickening agent.
Further, the thickener comprises the following components in a weight ratio (0.05-1): (0.1-5) carbomer and polyacrylamide. Carbomer is a common thickener in cosmetics and a very important rheology regulator, can form gel to achieve good stability and use feeling, and is widely applied to preparation of creams and emulsions. However, in the process of the invention, the carbomer is compatible with the sialic acid, and a flocculation reaction is generated. The present invention employs a sialylate to avoid this phenomenon. The skin care milk adopting the thickener has excellent physical and chemical stability, and meanwhile, the obtained skin care milk has better skin feel so as to further meet the requirements of consumers.
In some specific embodiments, the oil-in-water skin care emulsion further comprises 10-40 wt% of an oil emollient selected from one or more of isooctyl palmitate, polydimethylsiloxane, petrolatum, and squalane. Wherein the petrolatum is vaseline.
Furthermore, the oil-in-water type skin care emulsion also comprises the following components in percentage by weight: 0.1-5% of skin repairing agent, 0.1-20% of humectant, 0.1-1% of preservative and/or 0.1-2% of acid-base regulator.
In some specific embodiments, the skin repair agent is allantoin;
and/or the humectant is propylene glycol;
and/or the preservative is p-hydroxyacetophenone;
and/or the pH regulator is sodium carbonate.
In some specific embodiments, the oil-in-water skin care lotion comprises the following raw materials in percentage by weight: 0.1-2% of sialic acid salt, 212-5% of steareth-212%, 21-5% of steareth, 1-3% of cetearyl alcohol, 2-10% of isooctyl palmitate, 2-10% of polydimethylsiloxane, 5-10% of petrolatum, 1-10% of squalane, 0.1-20% of propylene glycol, 0.1-5% of allantoin, 0.05-1% of carbomer, 0.1-5% of polyacrylamide, 0.1-2% of sodium carbonate, 0.1-1% of p-hydroxyacetophenone and the balance of deionized water.
In a second aspect of the present invention, there is provided a method for preparing the aforementioned oil-in-water type skin care emulsion containing a sialylate, comprising the steps of:
(1) weighing the components according to the weight percentage for later use;
(2) sequentially adding thickener, moisturizer and deionized water into a vacuum emulsifying pot, heating in water bath to 75-85 deg.C under stirring, and keeping the temperature for 10-15 min;
(3) sequentially adding emulsifier and oil emollient into oil phase pan, stirring, heating in water bath to 75-85 deg.C, and keeping the temperature for 10-15 min;
(4) adding the materials in the oil phase pot into a vacuum emulsifying pot, homogenizing at 10000-15000rpm for 10-15min until a uniform emulsified body is formed, continuing stirring, adding the sialylate, the skin repairing agent, the acid-base regulator and the preservative when the temperature is reduced to 40-45 ℃, observing the uniformity of the material body, and cooling to room temperature to discharge.
The invention has the following advantages:
the invention applies the sialic acid salt to an oil-in-water system, and solves the problem that the degradation of sialic acid and the reduction of viscosity of a thickening body (particularly a thickening body containing carbomer) cause the instability of the system. According to the invention, through a large amount of researches on the emulsifier and the thickener of the skin care emulsion, the sialylate can stably exist in the obtained oil-in-water system, and the obtained skin care emulsion has excellent physical and chemical stability and good skin feel, so that the quality of cosmetics is remarkably improved.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
In the following examples and comparative examples, "%" means weight percent, unless otherwise specified.
Example 1
The embodiment provides an oil-in-water skin care emulsion containing a sialylate, which comprises the following components in percentage by weight: 1% of sodium sialate, 214.2% of steareth-21%, 3% of cetearyl alcohol, 5% of isooctyl palmitate, 2.2% of polydimethylsiloxane, 10% of petrolatum, 10% of squalane, 12% of propylene glycol, 1.5% of allantoin, 0.6% of carbomer, 2% of polyacrylamide, 0.5% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the oil-in-water type skin care milk comprises the following steps:
(1) weighing the raw materials according to the weight percentage for later use;
(2) sequentially adding carbomer, polyacrylamide, propylene glycol and deionized water into a vacuum emulsifying pot, heating to 80 ℃ in a water bath under the stirring condition, and keeping the temperature for 12 min;
(3) adding steareth-21, steareth-2, glyceryl stearate, PEG-100 stearate, cetostearyl alcohol, isooctyl palmitate, polydimethylsiloxane, petrolatum, and squalane into an oil phase pot in sequence, heating to 80 deg.C in water bath under stirring, and keeping the temperature for 15 min;
(4) adding the materials in the oil phase pot into a vacuum emulsifying pot, homogenizing at 12000rpm for 10min until a uniform emulsified body is formed, continuing stirring, cooling to 40 deg.C, adding sialylate, allantoin, sodium carbonate, and p-hydroxyacetophenone, observing the uniformity of the material body, and cooling to room temperature to obtain the final product.
Example 2
The embodiment provides an oil-in-water skin care milk containing a sialylate, which comprises the following raw materials in percentage by weight: 0.5% of sodium sialate, 213.5% of steareth-21.6% of steareth, 2% of cetostearyl alcohol, 5% of isooctyl palmitate, 3% of polydimethylsiloxane, 9% of petrolatum, 5% of squalane, 12% of propylene glycol, 1.5% of allantoin, 0.8% of carbomer, 2% of polyacrylamide, 0.8% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 3
The embodiment provides an oil-in-water skin care milk containing a sialylate, which comprises the following raw materials in percentage by weight: 1.5% of sodium sialate, 212.5% of steareth-212.2%, 23.2% of steareth-2, 2.5% of cetostearyl alcohol, 5% of isooctyl palmitate, 3% of polydimethylsiloxane, 8% of petrolatum, 1% of squalane, 10% of propylene glycol, 1% of allantoin, 0.8% of carbomer, 2.5% of polyacrylamide, 1% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 4
The embodiment provides an oil-in-water skin care milk containing a sialylate, which comprises the following raw materials in percentage by weight: 2% of sodium sialate, 8% of steareth-213.8%, 24% of steareth, 2% of cetostearyl alcohol, 6% of isooctyl palmitate, 7% of polydimethylsiloxane, 5% of petrolatum, 5% of squalane, 12% of propylene glycol, 1.2% of allantoin, 0.5% of carbomer, 3% of polyacrylamide, 0.6% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 5
The embodiment provides an oil-in-water skin care milk containing a sialylate, which comprises the following raw materials in percentage by weight: 1% of sodium sialate, 212% of steareth-212%, 24.5% of steareth-24.5%, 1.5% of cetearyl alcohol, 3% of isooctyl palmitate, 8% of polydimethylsiloxane, 4% of petrolatum, 2% of squalane, 10% of propylene glycol, 1.8% of allantoin, 1% of carbomer, 3% of polyacrylamide, 0.8% of sodium carbonate, 0.5% of p-hydroxyacetophenone and the balance of deionized water.
The preparation method of the skin care cream of this example is the same as that of example 1.
Example 6
The present example is different from example 1 only in the thickening agent used, and the oil-in-water skin care emulsion of the present example includes 2% of carbomer and 0.6% of polyacrylamide.
The preparation method of the skin care cream of this example is the same as that of example 1.
Comparative example 1
This comparative example differs from example 1 only in that the emulsifier used is different and steareth-21 in example 1 is replaced with an equivalent amount of PEG-100 stearate.
The skin care milk of this comparative example was prepared in the same manner as in example 1.
Comparative example 2
This comparative example differs from example 1 only in that the emulsifier used is different and steareth-21 in example 1 is replaced by an equivalent amount of glyceryl stearate.
The skin care milk of this comparative example was prepared in the same manner as in example 1.
Comparative example 3
The comparative example differs from example 1 only in the emulsifiers used, including steareth-210.6%, steareth-25%, cetearyl alcohol 2.5%
The skin care milk of this comparative example was prepared in the same manner as in example 1.
Comparative example 4
This comparative example differs from example 1 only in that the thickening agent used is different, the polyacrylamide in example 1 being replaced by an equal amount of xanthan gum.
The skin care milk of this comparative example was prepared in the same manner as in example 1.
Test example 1
The oil-in-water type skin care milk of the present invention was tested for high temperature stability and long term stability.
High-temperature stability: the skin-care milks of examples 1-6 and comparative examples 1-4 were respectively placed in suitable containers, placed in a constant-temperature drying oven at 50 ℃ for 10 days, and sampled at 0 th, 5 th and 10 th days, respectively, to examine the properties, the content of sialylate and the pH of the skin-care milks.
Long-term stability: the skin care milks of examples 1 to 6 and comparative examples 1 to 4 were placed in suitable containers, respectively, in a constant temperature drying oven at (28 ± 2) ° c for 12 months, and samples were taken at the end of 0, 3, 6, 9, and 12 months, respectively, to examine the properties, the content of sialylate, and the pH of the skin care milks.
The test results for high temperature stability and long term stability are shown in table 1.
TABLE 1
The results show that: the oil-in-water type skin care lotion of the present invention has excellent physical and chemical stability regardless of accelerated tests or long-term tests.
Test example 2
The oil-in-water type skin care emulsion of the invention is subjected to sanitary microorganism inspection and sanitary chemical inspection
The results of the sanitary microbiological examination and the sanitary chemical examination of the skin care cream prepared in example 1 of the present invention are shown in table 2.
TABLE 2
The results of the sanitary microbiological examination and the sanitary chemical examination of the skin care milks of examples 2 to 6 were not significantly different from those of example 1.
The results show that: the oil-in-water skin care emulsion meets the regulation of technical standards for cosmetic safety.
Test example 3
The feeling of use of the oil-in-water skin care milk of the present invention was evaluated.
Randomly selecting 30 subjects, cleaning face for 5min, applying 2 pumps of the oil-in-water skin care milk prepared in the invention in the embodiment 1, the embodiment 6 and the comparative example 4 on the face, filling in questionnaire after 30min, and counting to obtain the results shown in the table 3.
TABLE 3
The results show that: the texture, touch and skin feel of the oil-in-water skin care emulsion of example 1 are more satisfactory to consumers than those of example 6 and comparative example 4.
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. An oil-in-water skin care emulsion containing a sialylate is characterized in that the sialylate is used as the only functional component or one of the functional components.
2. The sialylated oil-in-water skin care milk according to claim 1, which comprises a sialylate and an emulsifier;
and/or the weight percentage content of the sialic acid salt in the oil-in-water skin care milk is 0.1-2%; the weight percentage of the emulsifier in the oil-in-water skin care milk is 4-13%.
3. The skin care oil-in-water emulsion containing a salt of sialic acid of claim 2, wherein the salt of sialic acid is selected from one or more of sodium sialylate, potassium sialylate, calcium sialylate, magnesium sialylate;
and/or the emulsifier comprises the following components in a weight ratio of (2-5): (1-5): steareth-21, steareth-2 and cetearyl alcohol of (1-3).
4. The sialylated oil-in-water skin care milk according to any of claims 1 to 3, which further comprises a thickener in an amount of from 0.15 to 6% by weight.
5. The sialylated oil-in-water skin care milk according to claim 4, characterised in that the thickener comprises, in weight ratio (0.05-1): (0.1-5) carbomer and polyacrylamide.
6. The sialylated oil-in-water skin care milk according to any of claims 1 to 5, which further comprises from 10 to 40% by weight of an oil-in-water emollient; the oil emollient is selected from one or more of isooctyl palmitate, polydimethylsiloxane, petrolatum and squalane.
7. The sialylated oil-in-water skin care milk according to any of claims 1 to 6, which further comprises the following components in weight percent: 0.1-5% of skin repairing agent, 0.1-20% of humectant, 0.1-1% of preservative and/or 0.1-2% of acid-base regulator.
8. The sialylated oil-in-water skin care milk according to claim 7, characterised in that the skin repair agent is allantoin;
and/or the humectant is propylene glycol;
and/or the preservative is p-hydroxyacetophenone;
and/or the pH regulator is sodium carbonate.
9. The sialylated oil-in-water skin care milk according to claim 1, which comprises the following components in percentage by weight: 0.1-2% of sialic acid salt, 212-5% of steareth-212%, 21-5% of steareth, 1-3% of cetearyl alcohol, 2-10% of isooctyl palmitate, 2-10% of polydimethylsiloxane, 5-10% of petrolatum, 1-10% of squalane, 0.1-20% of propylene glycol, 0.1-5% of allantoin, 0.05-1% of carbomer, 0.1-5% of polyacrylamide, 0.1-2% of sodium carbonate, 0.1-1% of p-hydroxyacetophenone and the balance of deionized water.
10. A method of preparing a sialylated oil-in-water skin care milk according to any of claims 1 to 9, which comprises the steps of:
(1) weighing the components according to the weight percentage for later use;
(2) sequentially adding the thickening agent, the humectant and the deionized water into a vacuum emulsifying pot, stirring, heating in water bath to 75-85 ℃, and keeping the temperature for 10-15 min;
(3) sequentially adding emulsifier and oil emollient into oil phase pan, stirring, heating in water bath to 75-85 deg.C, and keeping the temperature for 10-15 min;
(4) adding the materials in the oil phase pot into a vacuum emulsifying pot, homogenizing at 10000-15000rpm for 10-15min until a uniform emulsified body is formed, continuing stirring, adding the sialylate, the skin repairing agent, the acid-base regulator and the preservative when the temperature is reduced to 40-45 ℃, observing the uniformity of the material body, and cooling to room temperature to discharge.
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Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103735470A (en) * | 2014-01-23 | 2014-04-23 | 广州丹奇日用化工厂有限公司 | Two-phase cosmetic containing apple stem cell extract and preparation method thereof |
| CN104000756A (en) * | 2014-01-08 | 2014-08-27 | 惠州孕美生物科技有限公司 | Hydrating moistening cosmetic containing rice extract and preparation method thereof |
| CN107281005A (en) * | 2017-05-25 | 2017-10-24 | 珀莱雅化妆品股份有限公司 | A kind of preparation method of the nanometer emulsified liquid of anti-wrinkle composition and its PIT |
| CN108042407A (en) * | 2017-10-10 | 2018-05-18 | 山西潞安煤基合成油有限公司 | A kind of Fischer-Tropsch wax oil-in-water skin care lotion and preparation method thereof |
| CN109010174A (en) * | 2018-09-07 | 2018-12-18 | 广州蜜颜秀生物科技有限公司 | A kind of composition, the eczema ointment containing the composition |
| CN109394585A (en) * | 2018-12-10 | 2019-03-01 | 无限极（中国）有限公司 | A kind of anti-oxidant and moisturizing liquid-crystal composition and its preparation method and application |
| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN111000759A (en) * | 2019-11-10 | 2020-04-14 | 广州力瑧进出口贸易有限公司 | Bergamot essential oil repair cream and preparation method thereof |
| CN111000738A (en) * | 2020-01-03 | 2020-04-14 | 北京幸福益生再生医学科技有限公司 | Anti-aging cosmetic and preparation method thereof |
| CN113398016A (en) * | 2021-07-30 | 2021-09-17 | 上海新高姿化妆品有限公司 | Skin soothing and repairing composition and cosmetic composition |
| CN113616536A (en) * | 2021-09-10 | 2021-11-09 | 广州筱蔻生物科技有限公司 | Anti-aging composition, preparation method and application |
-
2021
- 2021-12-09 CN CN202111501671.2A patent/CN114344185B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000756A (en) * | 2014-01-08 | 2014-08-27 | 惠州孕美生物科技有限公司 | Hydrating moistening cosmetic containing rice extract and preparation method thereof |
| CN103735470A (en) * | 2014-01-23 | 2014-04-23 | 广州丹奇日用化工厂有限公司 | Two-phase cosmetic containing apple stem cell extract and preparation method thereof |
| CN107281005A (en) * | 2017-05-25 | 2017-10-24 | 珀莱雅化妆品股份有限公司 | A kind of preparation method of the nanometer emulsified liquid of anti-wrinkle composition and its PIT |
| CN108042407A (en) * | 2017-10-10 | 2018-05-18 | 山西潞安煤基合成油有限公司 | A kind of Fischer-Tropsch wax oil-in-water skin care lotion and preparation method thereof |
| CN109010174A (en) * | 2018-09-07 | 2018-12-18 | 广州蜜颜秀生物科技有限公司 | A kind of composition, the eczema ointment containing the composition |
| CN109394585A (en) * | 2018-12-10 | 2019-03-01 | 无限极（中国）有限公司 | A kind of anti-oxidant and moisturizing liquid-crystal composition and its preparation method and application |
| CN110368323A (en) * | 2019-08-05 | 2019-10-25 | 广州市玉鑫化妆品有限公司 | A kind of composite skin care product and its preparation method and application containing liquid crystal emulsifier |
| CN111000759A (en) * | 2019-11-10 | 2020-04-14 | 广州力瑧进出口贸易有限公司 | Bergamot essential oil repair cream and preparation method thereof |
| CN111000738A (en) * | 2020-01-03 | 2020-04-14 | 北京幸福益生再生医学科技有限公司 | Anti-aging cosmetic and preparation method thereof |
| CN113398016A (en) * | 2021-07-30 | 2021-09-17 | 上海新高姿化妆品有限公司 | Skin soothing and repairing composition and cosmetic composition |
| CN113616536A (en) * | 2021-09-10 | 2021-11-09 | 广州筱蔻生物科技有限公司 | Anti-aging composition, preparation method and application |
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