JPS63301826A - Drug for external use - Google Patents
Drug for external useInfo
- Publication number
- JPS63301826A JPS63301826A JP13707387A JP13707387A JPS63301826A JP S63301826 A JPS63301826 A JP S63301826A JP 13707387 A JP13707387 A JP 13707387A JP 13707387 A JP13707387 A JP 13707387A JP S63301826 A JPS63301826 A JP S63301826A
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- molecular weight
- salt
- drug
- external use
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 title abstract 5
- 239000003814 drug Substances 0.000 title abstract 5
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 36
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 36
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 36
- 150000003839 salts Chemical class 0.000 claims abstract description 14
- 238000002360 preparation method Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 11
- 239000002537 cosmetic Substances 0.000 abstract description 10
- 239000006071 cream Substances 0.000 abstract description 8
- 239000006210 lotion Substances 0.000 abstract description 8
- 239000002585 base Substances 0.000 abstract description 7
- 239000000126 substance Substances 0.000 abstract description 4
- 239000002253 acid Substances 0.000 abstract description 3
- 239000003513 alkali Substances 0.000 abstract description 3
- 210000002808 connective tissue Anatomy 0.000 abstract description 3
- 238000002156 mixing Methods 0.000 abstract description 2
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 12
- 239000003921 oil Substances 0.000 description 12
- 235000019198 oils Nutrition 0.000 description 12
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 8
- 239000008346 aqueous phase Substances 0.000 description 7
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 6
- 239000000839 emulsion Substances 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 5
- -1 alkali metal salts Chemical class 0.000 description 5
- 235000019441 ethanol Nutrition 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 229940010747 sodium hyaluronate Drugs 0.000 description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 5
- 235000011187 glycerol Nutrition 0.000 description 4
- 239000012071 phase Substances 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 235000021355 Stearic acid Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229960000735 docosanol Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 229940057995 liquid paraffin Drugs 0.000 description 3
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 229940032094 squalane Drugs 0.000 description 3
- 239000008117 stearic acid Substances 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 239000004166 Lanolin Substances 0.000 description 2
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000010696 ester oil Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 235000019388 lanolin Nutrition 0.000 description 2
- 229940039717 lanolin Drugs 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- 239000012188 paraffin wax Substances 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- VLPFTAMPNXLGLX-UHFFFAOYSA-N trioctanoin Chemical compound CCCCCCCC(=O)OCC(OC(=O)CCCCCCC)COC(=O)CCCCCCC VLPFTAMPNXLGLX-UHFFFAOYSA-N 0.000 description 2
- 229940099259 vaseline Drugs 0.000 description 2
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 229940124274 edetate disodium Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940060184 oil ingredients Drugs 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
【発明の詳細な説明】
〔産業上の利用分野〕
本発明はべたつき、ぬめり等の無い皮膚使用感覚の優れ
たヒアルロン酸を含有した外用剤に関するものである。DETAILED DESCRIPTION OF THE INVENTION [Industrial Field of Application] The present invention relates to an external preparation containing hyaluronic acid that is free from stickiness, sliminess, etc. and has an excellent feeling when used on the skin.
ヒアルロン酸は哺乳動物の結合組織に存在するグルクロ
ン酸とＮ−アセチルグルコサミンがβ−３結合した反復
単位を持つ直鎖状高分子であり、この長い分子鎖は水溶
液で抱水して粘性を示すことから、ヒアルロン酸を用い
て皮膚の保湿効果を与える目的で化粧料などに使用して
いたっしかしながら、その分子量が高分子（５０万〜２
００万）であるため、皮膚に対する浸透性が極めて低く
、また長期に保存すると著しい粘度の低下を生ずる等の
欠点があった。Hyaluronic acid is a linear polymer that exists in the connective tissues of mammals and has repeating units in which glucuronic acid and N-acetylglucosamine are linked with β-3 bonds, and this long molecular chain exhibits viscosity when hydrated in an aqueous solution. For this reason, hyaluronic acid has been used in cosmetics to provide a moisturizing effect on the skin, but its molecular weight is high (500,000 to 2,000 yen).
Because it was 00,000), the penetration of the skin was extremely low, and the long -term preservation caused a significant decrease in viscosity.
°そこで、ヒアルロン酸のこのような欠点を解決するた
め、分子量が１万〜ｌＯ万のヒアルロン酸を含有した皮
膚化粧料が開示されている（特開昭５９−２１９２０９
号公報）。Therefore, in order to solve these drawbacks of hyaluronic acid, skin cosmetics containing hyaluronic acid with a molecular weight of 10,000 to 10,000 have been disclosed (Japanese Patent Laid-Open No. 219-209-1989).
Publication No.).
上記分子量１万〜１０万のヒアルロン酸を用いた化粧料
においても、その化粧料基剤に添加する量が０．１〜０
．２％が限度でありヒアルロン酸の効果を充分に奏する
ことが出来ないばかりでなく、製剤上種々工夫が必要で
あった。また、「べとつき感」等の皮膚に対する感触が
未だ解決されていない等の難点があった。Even in cosmetics using hyaluronic acid with a molecular weight of 10,000 to 100,000, the amount added to the cosmetic base is 0.1 to 0.
．． 2% is the limit, which not only makes it impossible to fully exhibit the effects of hyaluronic acid, but also requires various ingenuity in formulation. In addition, there have been drawbacks such as a ``sticky feeling'' to the skin, which has not yet been resolved.
本発明は以上の問題点を解決し、外用基剤に対し任意に
配合が出来、しかも「べたつき」、「ぬめり」等の皮膚
に対する不快感をなくし、「さっばりコした使用感を与
えるヒアルロン酸の外用剤を提供することを目的とする
ものである。The present invention solves the above-mentioned problems, and can be added to external bases at will. Hyaluronic acid eliminates discomfort to the skin such as stickiness and sliminess, and provides a light and firm feel. The purpose of the present invention is to provide an external preparation for the following.
本発明は分子！１万未満のヒアルロン酸又は／及びその
塩を含有することを特徴をする外用剤である。This invention is a molecule! This external preparation is characterized by containing less than 10,000 hyaluronic acid or/and a salt thereof.
本発明に使用する分子量１万未満のヒアルロン酸は、哺
乳動物の結合組織に存在するヒアルロン酸を酵素処理、
酸、アルカリ処理、熱処理などの処理により低分子化し
、この処理物より高分子量の物質を除去した物質で、分
子量１万未満のヒアルロン酸及びその塩である。本発明
に使用するものは平均分子量９０００〜３０００を有す
るものが好適である。Hyaluronic acid with a molecular weight of less than 10,000 used in the present invention is obtained by enzymatically treating hyaluronic acid present in mammalian connective tissues.
Hyaluronic acid and its salts have a molecular weight of less than 10,000, and are made into low-molecular substances through treatments such as acid, alkali, and heat treatments, and from which high-molecular-weight substances are removed. Those used in the present invention preferably have an average molecular weight of 9,000 to 3,000.
また、このヒアルロン酸の塩としては、ナトリウム、カ
リウムなどのアルカリ金属塩等が挙げられる。Further, examples of the salt of hyaluronic acid include alkali metal salts such as sodium and potassium.
本発明の外用剤は上記の分子量１万未満のヒアルロン酸
又は塩を通常の外用剤基剤、助剤などに配合調製して化
粧水、クリ°−ム、乳液、バックなどの外用剤とする。The external preparation of the present invention is prepared by blending the above-mentioned hyaluronic acid or salt with a molecular weight of less than 10,000 with a usual external preparation base, auxiliary agent, etc. to form an external preparation such as a lotion, cream, emulsion, bag, etc. .
このヒアルロン酸又はその塩は各種外用剤の全量に対し
０．１〜５％程度配合すれば充分その効果を奏し得る、
しかし、必要によっては、任意の量を外用基剤に配合し
うるちのである。If this hyaluronic acid or its salt is blended in an amount of about 0.1 to 5% based on the total amount of various external preparations, the effect can be sufficiently exerted.
However, if necessary, any amount can be added to the external base.
本発明の外用剤とする場合は、例えば化粧水においては
、精製水にグリセリン、プロピレングリコールなどの保
湿剤、皮膚栄養剤等を溶かし、防腐剤、香料などをアル
コールに溶解し、両者を混合して室温下に可溶化する一
般の化粧水の製造において、水相に有効成分である分子
量１万未満のヒアルロン酸及び／又はその塩を加えて化
粧水とする。When preparing an external preparation of the present invention, for example, in a lotion, moisturizers such as glycerin and propylene glycol, skin nutrients, etc. are dissolved in purified water, preservatives, fragrances, etc. are dissolved in alcohol, and the two are mixed. In the production of a general lotion, which is solubilized at room temperature, the active ingredient, hyaluronic acid and/or its salt with a molecular weight of less than 10,000, is added to the aqueous phase to prepare the lotion.
クリームにおいては、精製水に親水性成分例えばグリセ
リン、ソルビットなどの保湿剤を添加して水相とし、油
相部はミツロウ、パラフィン、マイクロクリスタリンワ
ッッス、セレシン、高級脂肪酸、硬化油などの固形油分
、ワセリン、ラノリン、グリセリドなどの半固形油分そ
れにスクヮラン、流動パラフィン、各種エステル油など
の液状油分に防腐剤、界面活性剤などの油性成分を添加
し調製する。このようにして得られた水相部を加温して
、緩やかに撹拌しつつ、同温度に加温された油相部を徐
々に添加し乳化してクリームとする一般のクリームの製
造において、水相部に有効成分である分子１１万未満の
ヒアルロン酸及び／又はその塩を加えてクリームとする
。In creams, hydrophilic ingredients such as humectants such as glycerin and sorbitol are added to purified water to form the aqueous phase, while the oil phase contains solids such as beeswax, paraffin, microcrystalline wax, ceresin, higher fatty acids, and hydrogenated oil. It is prepared by adding oily components such as preservatives and surfactants to semi-solid oils such as oil, vaseline, lanolin, and glyceride, and liquid oils such as squalane, liquid paraffin, and various ester oils. In the production of general cream, the aqueous phase obtained in this way is heated, and while gently stirring, the oil phase heated to the same temperature is gradually added and emulsified to make cream. The active ingredient, hyaluronic acid with a molecular weight of less than 110,000 and/or its salt, is added to the aqueous phase to form a cream.
乳液においては、精製水にグリセリンなどの保湿剤、酸
又はアルカリのＰ）！調整剤などを加え、加熱混合して
エタノールを加え水相部とし、ミツロウ、パラフィンな
どの固形油分、ワセリン、ラノリンなどの半固形油分、
スクワラン、流動パラフィン、各種エステル油などの液
状油分に、防腐剤。In emulsions, purified water, humectants such as glycerin, and acid or alkali P)! Add regulators, etc., mix with heat, and add ethanol to form the aqueous phase. Solid oils such as beeswax and paraffin, semi-solid oils such as vaseline and lanolin,
Preservatives for liquid oils such as squalane, liquid paraffin, and various ester oils.
界面活性剤などの油性成分を添加調製して混合加熱し油
相部とし、油相部を水相部に加えて予備乳化を行い、こ
れにカルボキシビニルポリマー、カルボキシメチルセル
ロースなどの保護コロイド剤を加え、ホモミキサーで均
一に乳化して乳液とする一般の乳液の製造において、水
相部に有効成分である分子１１万未満のヒアルロン酸及
び／又はその塩を水相部に加えて乳液とする。Oily components such as surfactants are added and prepared, mixed and heated to form an oil phase, the oil phase is added to the aqueous phase for preliminary emulsification, and a protective colloid such as carboxyvinyl polymer or carboxymethyl cellulose is added to this. In the production of a general emulsion, which is uniformly emulsified using a homomixer to form an emulsion, an active ingredient, hyaluronic acid and/or its salt having molecules of less than 110,000, is added to the aqueous phase to form an emulsion.
パンクにおいては、精製水にグリセリンなどの保ＪＩ剤
、ポリビニルアルコール、ビーガムなどの皮膜剤などを
加えて膨潤させ、これに必要があればカオリン、タルク
、酸化亜鉛などの粉末を加え、香料、防腐剤などを溶解
したエタノールを加えて、ペースト状となるまで混練す
る一般のパックの製造において、有効成分である分子量
１万未満のヒアルロン酸及び／又はその塩を加えてパッ
クとする。For punctures, add JI inhibitors such as glycerin, film agents such as polyvinyl alcohol, and Veegum to purified water to swell it, and if necessary, add powders such as kaolin, talc, and zinc oxide to add fragrance and preservatives. In the production of general packs, in which ethanol in which agents are dissolved is added and kneaded until it becomes a paste, the active ingredient, hyaluronic acid and/or its salt with a molecular weight of less than 10,000, is added to form a pack.
次に本発明の有効成分である分子量１万未満のヒアルロ
ン酸の製造例を示す。Next, a production example of hyaluronic acid having a molecular weight of less than 10,000, which is the active ingredient of the present invention, will be shown.
製造例
ヒアルロン酸ナトリウム１５ｇを０．２％乳酸溶液１．
０００ｇに加え充分に混合し、１２０℃で６０〜９０分
間加熱する。この液を冷却し、活性炭０．２％を添加し
、脱色後濾過する。Production Example 15g of sodium hyaluronate was added to a 0.2% lactic acid solution.
000g, mix thoroughly and heat at 120°C for 60 to 90 minutes. This liquid is cooled, 0.2% of activated carbon is added, and after decolorization, it is filtered.
その濾液を１０％水酸化ナトリウム溶液でｐＨ７，Ｏに
調整する。この溶液にパラオキシ安息香酸メチル０．１
８％、パラオキシ安息香酸エチル０．０７％、エチルア
ルコール５．０％になるようにｍ！ＩＩ！する。The filtrate is adjusted to pH 7.0 with 10% sodium hydroxide solution. Add 0.1 methyl paraoxybenzoate to this solution.
8%, ethyl paraoxybenzoate 0.07%, and ethyl alcohol 5.0% m! II! do.
かくして得られたヒアルロン酸を含有する液は、ｐＨ６
゜４７、比重１，０００ 、分子量９０００のヒアルロ
ン酸１．０１％を含有する。The thus obtained hyaluronic acid-containing liquid has a pH of 6.
Contains 1.01% of hyaluronic acid with a specific gravity of 1,000 and a molecular weight of 9,000.
次に本発明の実施例を挙げる。Next, examples of the present invention will be described.
例１ （化粧水）
ポリオキンエチレン硬化ヒマシ油
（６０１Ｅ、 ０． ） １
．００％エタノール １５．００
％バラオキシ安息香酸エステル ０．１０％クエン
酸 ０．１０％クエン酸ナト
リウム ０．３０％１．３−ブチレング
リコール ４．００％ヒアルロン酸ナトリウム
（分子量９０００）１０．０％
ｆｉｔ！！！水を加えて、全量を１００ｇとする。Example 1 (Lotion) Polyquine ethylene hydrogenated castor oil (601E, 0.) 1
．． 00% ethanol 15.00
% roseoxybenzoate 0.10% citric acid 0.10% sodium citrate 0.30% 1.3-butylene glycol 4.00% sodium hyaluronate (molecular weight 9000) 10.0% fit! ! ! Add water to bring the total amount to 100g.
例２ （クリーム）
モノステアリン酸ポリエチレングリ
コール（４０ε、 （３） ２．
００％自己乳化型モノステアリン酸グリセ
リ ン
５，００％ステアリン酸
５．００％ベヘニルアルコール
１．００％流動パラフィン １０．０
０％トリオクタン酸グリセリル １０．００％バ
ラオキシ安息香酸エステル ０．２０％１．３−ブ
チレングリコール ５．００％エデト酸二ナト
リウム ０．０１％ヒアルロン酸ナトリウ
ム（分子量９０００）５．００％
精製水を加えて全量を１００ｇとする。Example 2 (Cream) Polyethylene glycol monostearate (40ε, (3) 2.
00% self-emulsifying glyceryl monostearate
5,00% stearic acid
5.00% behenyl alcohol
1.00% liquid paraffin 10.0
0% glyceryl trioctanoate 10.00% roseoxybenzoate ester 0.20% 1.3-butylene glycol 5.00% disodium edetate 0.01% sodium hyaluronate (molecular weight 9000) 5.00% Add purified water to make the total amount 100g.
例３ （クリームパック）
モノステアリン酸ポリエチレングリ
コーノベ４０Ｅ、 ０． ） ２
．００％自己乳化型モノステアリン酸グリセ
リ ン
５．００％ステアリン酸
５．００％ベヘニルアルコール ０．
５０％スクワラン １５．００％
オクタン酸セチル ５，００％バラオキ
シ安息香酸エステル ０，２０％１．３−ブチレン
グリコール ５．００％エデト酸二ナトリウム
０．０１％ヒアルロン酸ナトリウム（分子
１９０００）６．００％
精製水を加えて１００ｇとする。Example 3 (Cream pack) Monostearate polyethylene glyconobe 40E, 0. ) 2
．． 00% self-emulsifying glyceryl monostearate
5.00% stearic acid
5.00% behenyl alcohol 0.
50% squalane 15.00%
Cetyl octoate 5,00% Roseoxybenzoate ester 0,20% 1.3-butylene glycol 5.00% Disodium edetate 0.01% Sodium hyaluronate (molecule 19000) 6.00% Add purified water to 100g shall be.
例４ （乳液）
モノステアリン酸ポリオキシエチレン
ソルビタン（２０Ｅ、 ０． ） １
．００％テトラオレイン酸ポリオキシソルビット（６０
Ｂ、０．）
０．５０％親油型モノステアリン酸グリ
セリン１．００％ステアリン酸 ０
．５０％ベヘニルアルコール ０．５０％
アボガド油 ４．００％トリオク
タン酸グリセリル ４．００％バラオキシ安息
香酸エステル ０．２０％１．３−ブチレングリコ
ール ５．００％キサンタンガム
０．１４％エデト酸二ナトリウム
０．０１％ヒアルロン酸ナトリウム（分子１９０００）
８．００％
ＭＷ水を加えて全量を１００ｇとする。Example 4 (Emulsion) Polyoxyethylene sorbitan monostearate (20E, 0.) 1
．． 00% polyoxysorbitol tetraoleate (60
B, 0. )
0.50% lipophilic glycerin monostearate 1.00% stearic acid 0
．． 50% behenyl alcohol 0.50%
Avocado oil 4.00% glyceryl trioctanoate 4.00% roseoxybenzoate 0.20% 1.3-butylene glycol 5.00% xanthan gum
0.14% edetate disodium
0.01% Sodium Hyaluronate (Molecular 19000)
Add 8.00% MW water to bring the total amount to 100 g.
上記実施例１の化粧水のフィーリングを、分子量１０万
のヒアルロン酸を用いて実施例１の通り製造した化粧水
及び分子量１００〜２００万のヒアルロン酸を用いて実
施例１の通り製造した化粧水とを対比した試験例を下記
表に示す。The feeling of the lotion of Example 1 above was compared to the lotion manufactured as in Example 1 using hyaluronic acid with a molecular weight of 100,000 and the makeup manufactured as in Example 1 using hyaluronic acid with a molecular weight of 1 million to 2 million. Test examples comparing water with water are shown in the table below.
表
表中供試化粧液のΔは実施例１の化粧料、Ｂは分子量１
０万のヒアルロン酸を分子１９０００のヒアルロン酸の
代わりに用い実施例１と同様の処方で得た化粧料、Ｃは
分子量１００〜２００万のヒアルロン酸を分子１９００
０のヒアルロン酸の代わりに用い実施例１と同様の処方
で得た化粧料である。In the table, Δ of the sample cosmetic liquid is the cosmetic of Example 1, B is the molecular weight 1
Cosmetics obtained using the same formulation as in Example 1 using hyaluronic acid with a molecular weight of 1,900,000 instead of hyaluronic acid with a molecular weight of 19,000;
This is a cosmetic prepared using the same formulation as in Example 1, using hyaluronic acid instead of hyaluronic acid.
本発明は分子量１万未満のヒアルロン酸を含有した外用
剤であるから、保湿性、保水性は従来の高分子のヒアル
ロン酸を含有する化粧料と同等であるが、べたつき、ぬ
めり、つっばり感のない極めてさっばりした外用剤であ
る。そして更に、外用剤基剤との親和性がよく、任意の
量を外用剤基剤に含有させることができる利点があり、
有用な発明である。Since the present invention is an external preparation containing hyaluronic acid with a molecular weight of less than 10,000, its moisturizing and water-retaining properties are equivalent to those of conventional cosmetics containing high-molecular hyaluronic acid, but it does not feel sticky, slimy, or stiff. It is an extremely light topical preparation with no oil. Furthermore, it has a good affinity with the external preparation base and has the advantage that it can be contained in any desired amount in the external preparation base.
This is a useful invention.
Claims (1)
含有することを特徴とする外用剤。 ２、ヒアルロン酸及びその塩が分子量１万未満で平均分
子量９０００〜３０００である特許請求の範囲第１項記
載の外用剤。[Scope of Claims] 1. An external preparation characterized by containing hyaluronic acid and/or a salt thereof with a molecular weight of less than 10,000. 2. The external preparation according to claim 1, wherein the hyaluronic acid and its salt have a molecular weight of less than 10,000 and an average molecular weight of 9,000 to 3,000.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62137073A JP2549119B2 (en) | 1987-05-30 | 1987-05-30 | Topical |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP62137073A JP2549119B2 (en) | 1987-05-30 | 1987-05-30 | Topical |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS63301826A true JPS63301826A (en) | 1988-12-08 |
| JP2549119B2 JP2549119B2 (en) | 1996-10-30 |
Family
ID=15190268
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP62137073A Expired - Lifetime JP2549119B2 (en) | 1987-05-30 | 1987-05-30 | Topical |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2549119B2 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6413008A (en) * | 1987-06-12 | 1989-01-17 | Unilever Nv | Skin treatment composition |
| EP1707578A3 (en) * | 2005-02-15 | 2006-10-18 | Collagen Nutraceuticals, Inc. | Preparation of low molecular weight hyaluronic acid as a food supplement |
| WO2007099830A1 (en) * | 2006-02-24 | 2007-09-07 | Q.P. Corporation | Novel low molecular weight hyaluronic acid and/or salt thereof, and cosmetic preparation, pharmaceutical composition and food composition each using same |
| JP2008285421A (en) * | 2007-05-15 | 2008-11-27 | Q P Corp | Hair modifying penetrant and hair cosmetics using the same |
| EP2277510A2 (en) | 2002-10-16 | 2011-01-26 | Takeda Pharmaceutical Company Limited | Controlled release preparation |
| EP1865002A4 (en) * | 2005-03-22 | 2011-03-30 | Q P Corp | HYALURONIC ACID WITH LOW MOLECULAR WEIGHT AND / OR SALT THEREOF, PROCESS FOR PRODUCING THEM AND COSMETIC PREPARATION AND FOOD COMPOSITION CONTAINING SAME |
| WO2011129374A1 (en) * | 2010-04-14 | 2011-10-20 | ロート製薬株式会社 | Composition for external use for complexion improvement |
| JP2012012390A (en) * | 2010-06-04 | 2012-01-19 | Rohto Pharmaceutical Co Ltd | Hyaluronic acid-containing emulsified composition |
| JP2013504679A (en) * | 2009-09-15 | 2013-02-07 | イルドン ファーム カンパニー リミテッド | Low molecular weight hyaluronic acid production method |
| JP2016108344A (en) * | 2014-12-08 | 2016-06-20 | ワミレスコスメティックス株式会社 | Cosmetic containing small molecular weight of cationized hyaluronic acid |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61135045A (en) * | 1984-12-06 | 1986-06-23 | Matsushita Electronics Corp | High pressure sodium lamp for dc lighting |
-
1987
- 1987-05-30 JP JP62137073A patent/JP2549119B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61135045A (en) * | 1984-12-06 | 1986-06-23 | Matsushita Electronics Corp | High pressure sodium lamp for dc lighting |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6413008A (en) * | 1987-06-12 | 1989-01-17 | Unilever Nv | Skin treatment composition |
| EP2277510A2 (en) | 2002-10-16 | 2011-01-26 | Takeda Pharmaceutical Company Limited | Controlled release preparation |
| EP2283827A1 (en) | 2002-10-16 | 2011-02-16 | Takeda Pharmaceutical Company Limited | Controlled release preparation |
| EP1707578A3 (en) * | 2005-02-15 | 2006-10-18 | Collagen Nutraceuticals, Inc. | Preparation of low molecular weight hyaluronic acid as a food supplement |
| EP1865002A4 (en) * | 2005-03-22 | 2011-03-30 | Q P Corp | HYALURONIC ACID WITH LOW MOLECULAR WEIGHT AND / OR SALT THEREOF, PROCESS FOR PRODUCING THEM AND COSMETIC PREPARATION AND FOOD COMPOSITION CONTAINING SAME |
| US8933054B2 (en) | 2005-03-22 | 2015-01-13 | Q.P. Corporation | Low molecular weight hyaluronic acid and/or salt thereof, method for producing same, and cosmetic preparation and food composition containing same |
| JP5289936B2 (en) * | 2006-02-24 | 2013-09-11 | キユーピー株式会社 | Novel low molecular weight hyaluronic acid and / or salt thereof, and cosmetics, pharmaceutical compositions and food compositions using the same |
| US8367818B2 (en) | 2006-02-24 | 2013-02-05 | Q.P. Corporation | Low molecular weight hyaluronic acid and/or salt thereof, and cosmetic preparation, pharmaceutical composition, and food composition each using same |
| WO2007099830A1 (en) * | 2006-02-24 | 2007-09-07 | Q.P. Corporation | Novel low molecular weight hyaluronic acid and/or salt thereof, and cosmetic preparation, pharmaceutical composition and food composition each using same |
| JP2008285421A (en) * | 2007-05-15 | 2008-11-27 | Q P Corp | Hair modifying penetrant and hair cosmetics using the same |
| JP2013504679A (en) * | 2009-09-15 | 2013-02-07 | イルドン ファーム カンパニー リミテッド | Low molecular weight hyaluronic acid production method |
| WO2011129374A1 (en) * | 2010-04-14 | 2011-10-20 | ロート製薬株式会社 | Composition for external use for complexion improvement |
| JPWO2011129374A1 (en) * | 2010-04-14 | 2013-07-18 | ロート製薬株式会社 | External composition for improving skin quality |
| JP2016104809A (en) * | 2010-04-14 | 2016-06-09 | ロート製薬株式会社 | External composition for improving skin quality |
| JP2012012390A (en) * | 2010-06-04 | 2012-01-19 | Rohto Pharmaceutical Co Ltd | Hyaluronic acid-containing emulsified composition |
| JP2016033146A (en) * | 2010-06-04 | 2016-03-10 | ロート製薬株式会社 | Hyaluronic acid-containing emulsion composition |
| JP2017149780A (en) * | 2010-06-04 | 2017-08-31 | ロート製薬株式会社 | Hyaluronic acid-containing emulsion composition |
| JP2016108344A (en) * | 2014-12-08 | 2016-06-20 | ワミレスコスメティックス株式会社 | Cosmetic containing small molecular weight of cationized hyaluronic acid |
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| Publication number | Publication date |
|---|---|
| JP2549119B2 (en) | 1996-10-30 |
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