CN113616546B - Peach resin polysaccharide gum capable of brightening skin, application and extraction preparation method thereof - Google Patents
Peach resin polysaccharide gum capable of brightening skin, application and extraction preparation method thereof Download PDFInfo
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- 235000006040 Prunus persica var persica Nutrition 0.000 title claims abstract description 79
- 239000011347 resin Substances 0.000 title claims abstract description 27
- 229920005989 resin Polymers 0.000 title claims abstract description 27
- 150000004676 glycans Chemical class 0.000 title claims abstract description 14
- 229920001282 polysaccharide Polymers 0.000 title claims abstract description 14
- 239000005017 polysaccharide Substances 0.000 title claims abstract description 14
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 238000005282 brightening Methods 0.000 title claims abstract description 10
- 238000000605 extraction Methods 0.000 title claims abstract description 7
- 240000005809 Prunus persica Species 0.000 title description 3
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 76
- 239000000284 extract Substances 0.000 claims abstract description 36
- 241000026010 Dendrobium candidum Species 0.000 claims abstract description 13
- 241001506047 Tremella Species 0.000 claims abstract description 10
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 6
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 6
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 6
- 108090000637 alpha-Amylases Proteins 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 21
- 239000002537 cosmetic Substances 0.000 claims description 20
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 15
- 230000003020 moisturizing effect Effects 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000006071 cream Substances 0.000 claims description 13
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 11
- 238000002156 mixing Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 6
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 5
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 5
- 238000001914 filtration Methods 0.000 claims description 5
- 235000011187 glycerol Nutrition 0.000 claims description 5
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 5
- 238000011068 loading method Methods 0.000 claims description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims description 5
- 229920006122 polyamide resin Polymers 0.000 claims description 5
- 238000007873 sieving Methods 0.000 claims description 5
- 230000032683 aging Effects 0.000 claims description 2
- 239000003963 antioxidant agent Substances 0.000 claims description 2
- 230000003078 antioxidant effect Effects 0.000 claims description 2
- 230000001815 facial effect Effects 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- -1 pack Substances 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims 1
- 239000000654 additive Substances 0.000 abstract description 3
- 230000000996 additive effect Effects 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 63
- 239000000243 solution Substances 0.000 description 34
- 238000012360 testing method Methods 0.000 description 26
- 230000003110 anti-inflammatory effect Effects 0.000 description 20
- 230000014759 maintenance of location Effects 0.000 description 11
- 239000007933 dermal patch Substances 0.000 description 8
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 241001076416 Dendrobium tosaense Species 0.000 description 3
- 206010013786 Dry skin Diseases 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 230000037336 dry skin Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 208000035985 Body Odor Diseases 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 238000013100 final test Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 231100000430 skin reaction Toxicity 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses peach gum capable of brightening skin, application and an extraction preparation method thereof. The invention provides peach resin polysaccharide gum capable of brightening skin, which comprises the following components in parts by weight: 59.95-73 parts of peach resin extract; 0.05-1 part of dendrobium candidum extract; 10-15 parts of pullulanase polysaccharide; 10-15 parts of tremella extract; 1-10 parts of trehalose. The skin care product is mild and safe in use, can be used as an efficacy additive for preparing various skin care products, and further realizes the comprehensiveness and comprehensiveness of the efficacy of the skin care products.
Description
Technical Field
The invention relates to the technical field of daily chemical industry, in particular to a plant extract mixture with moisturizing and anti-inflammatory effects.
Background
Dry skin, hypoelasticity not only affects the appearance of the skin, but also can lead to subjective consumer discomfort and possibly exacerbation of certain skin conditions. The hydration state and the loss degree in the skin are directly related to the softness and the elasticity of the skin, and the moisture degree of the skin can be maintained to enhance the skin elasticity, enable the skin to be metabolized normally and reduce the generation of wrinkles and color spots. The moisture content of the stratum corneum of normal healthy skin is maintained at 10% to 20%. The moisturizing effect is the most basic function of the skin care cosmetics, and how to improve the moisturizing effect of the cosmetics has important significance on research and development of the cosmetics and clinical application of the medicine.
Peach gum is a polysaccharide natural substance, has moisturizing effect and thickening effect, is not easy to dissolve completely, and mainly comprises a hydrolysis method, an enzyme extraction method and the like in the preparation of the peach gum at present, however, the hydrolysis method has higher cost and is not beneficial to industrial production; enzyme extraction techniques have the disadvantage that the optimal temperature and optimal pH of the enzyme tend to be in a small range. In order to raise the activity of the enzyme to the highest value, the reaction temperature and pH of the enzyme must be very strictly controlled, and even small fluctuations in the reaction conditions are likely to greatly reduce the activity of the enzyme, and thus the demand for experimental facilities is high.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide peach gum capable of brightening skin, application and an extraction preparation method thereof.
The aim of the invention is realized by the following technical scheme:
the invention provides peach resin polysaccharide gum capable of brightening skin, which comprises the following components in percentage by weight:
preferably, the peach gum further comprises water, glycerol, 1, 2-hexanediol, and phenoxyethanol.
Preferably, the peach resin is produced by using water from Guizhou province.
The dendrobium candidum adopts dendrobium candidum with a hilly production area.
In a second aspect, the present invention provides a method for preparing the peach gum, the method comprising the steps of:
A. respectively crushing and sieving peach resin and dendrobium candidum, adding ethanol, and reflux-extracting for 4-8 hours at 50-100 ℃ with the weight-volume ratio of feed liquid being 1:5-50;
B. filtering the extractive solution, and vacuum concentrating until no alcohol smell;
C. adding water to the concentrated solution prepared in the step B, then loading the concentrated solution on a macroporous resin column or a polyamide resin column, eluting with 3-5 times of water, eluting with 4-6 times of ethanol water solution with the volume fraction of 30% -45% of the column volume, eluting with 3-5 times of ethanol water solution with the volume fraction of 50% -75% of the column volume, and eluting with 4-6 times of ethanol water solution with the volume fraction of 85% -95% of the column volume;
D. mixing the eluates, concentrating to 1/3-1/6 of the original weight to obtain the extracts of the components;
E. mixing the extracts according to the weight percentage to obtain the peach gum.
Preferably, in the step a, the ethanol is absolute ethanol.
Preferably, in the step B, the vacuum degree is less than 0.1MPa.
In a third aspect, the present invention provides an application of the peach gum, wherein the peach gum is used for preparing skin care cosmetics.
Preferably, the skin care cosmetic is selected from: moisturizing skin care cosmetics or antioxidant aging cosmetics.
Preferably, the skin care cosmetic is in the form of an aqueous solution, cream, emulsion, mask, gel, essence, facial cleanser, or bath lotion.
Preferably, the peach gum is 1% -10% of the total weight of the skin care cosmetic.
Compared with the prior art, the invention has the following beneficial effects:
1. the added natural components are safe, mild and effective, and have anti-inflammatory and conditioning effects on skin molting, itching, eczema, acne, pustule and other phenomena which are easy to occur.
2. Through the compound use, the effects of anti-inflammatory, moisturizing and nutrition are comprehensively exerted, and the skin-care and anti-inflammatory health care tea has the auxiliary effects of nourishing skin, diminishing inflammation, resisting oxidation and the like while moisturizing the skin, so that the effect of comprehensively improving the dry skin is achieved.
3. Not only has the function of relieving the existing symptoms, but also has the function of preventing or delaying the occurrence of bad conditions of the dry skin.
Drawings
Other features, objects and advantages of the present invention will become more apparent upon reading of the detailed description of non-limiting embodiments, given with reference to the accompanying drawings in which:
FIG. 1 shows a skin patch test of peach gum prepared by preparing peach gum of the invention into cream, wherein the mass percentage of the peach gum in the cream is 20%, and the condition of the skin patch is 24 hours; (b) a 48h skin patch test;
FIG. 2 shows an anti-inflammatory test using peach gum with an added mass percent of 0%, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 3 shows an anti-inflammatory test using peach gum with an added mass percent of 1%, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 4 shows the anti-inflammatory test with the addition of 3% by mass of peach gum, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 5 shows the anti-inflammatory test with the addition of peach gum at 5% by mass, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 6 shows an anti-inflammatory test with the addition of 10% by mass peach gum, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 7 shows an anti-inflammatory test with the addition of 20% by mass peach gum, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 8 shows the results of moisture retention after various times for peach gum concentrations;
fig. 9 shows the results after percutaneous moisturizing testing of peach gum at each concentration.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the present invention, but are not intended to limit the invention in any way. It should be noted that variations and modifications could be made by those skilled in the art without departing from the inventive concept. These are all within the scope of the present invention.
In the present invention, the term "peach resin extract" refers to an extract containing an active ingredient extracted from peach resin by any suitable means. The term "dendrobium candidum extract" refers to an extract containing active ingredients extracted from dendrobium candidum by any suitable means. The term "tremella root extract" refers to an extract containing active ingredients extracted from tremella by any suitable means.
The term "cosmetic" refers to any portion of a human body surface that is applied, sprayed, or the like, such as: skin, hair, nails, lips, teeth, etc., to achieve cleaning, maintenance, beauty, modification and change of appearance, or to correct human body odor, to maintain a good state. In a preferred embodiment according to the present invention, the cosmetic comprises: a moisturizing cosmetic, an anti-inflammatory cosmetic with moisturizing effect or an anti-aging cosmetic with moisturizing effect.
Example 1
The embodiment relates to peach gum capable of brightening skin, which comprises the following components in percentage by weight; peach resin extract: 73 parts; dendrobium officinale extract: 1 part; pullulanase polysaccharide: 10 parts; tremella extract: 10 parts; 5 parts of trehalose; 0.1 part of 1, 2-hexanediol and 0.1 part of phenoxyethanol, and glycerin: 0.8 parts.
The preparation method comprises the following steps:
A. respectively crushing and sieving peach resin and dendrobium candidum, adding ethanol, and reflux-extracting for 4-8 hours at 50-100 ℃ with the weight-volume ratio of feed liquid being 1:5-50;
B. filtering the extractive solution, and vacuum concentrating until no alcohol smell;
C. adding water to the concentrated solution prepared in the step B, then loading the concentrated solution on a macroporous resin column or a polyamide resin column, eluting with 3-5 times of water, eluting with 4-6 times of ethanol water solution with the volume fraction of 30% -45% of the column volume, eluting with 3-5 times of ethanol water solution with the volume fraction of 50% -75% of the column volume, and eluting with 4-6 times of ethanol water solution with the volume fraction of 85% -95% of the column volume;
D. mixing the eluates, concentrating to 1/3-1/6 of the original weight to obtain the extracts of the components;
E. mixing the extracts according to the weight components to obtain the peach gum.
Example 2
The embodiment relates to peach gum capable of brightening skin, which comprises the following components in percentage by weight; peach resin extract: 59.95 parts; dendrobium officinale extract: 0.05 parts; pullulanase polysaccharide: 15 parts; tremella extract: 15 parts; trehalose 9 parts; 0.1 part of 1, 2-hexanediol and 0.1 part of phenoxyethanol, and glycerin: 0.8 parts.
The preparation method comprises the following steps:
A. respectively crushing and sieving peach resin and dendrobium candidum, adding ethanol, and reflux-extracting for 4-8 hours at 50-100 ℃ with the weight-volume ratio of feed liquid being 1:5-50;
B. filtering the extractive solution, and vacuum concentrating until no alcohol smell;
C. adding water to the concentrated solution prepared in the step B, then loading the concentrated solution on a macroporous resin column or a polyamide resin column, eluting with 3-5 times of water, eluting with 4-6 times of ethanol water solution with the volume fraction of 30% -45% of the column volume, eluting with 3-5 times of ethanol water solution with the volume fraction of 50% -75% of the column volume, and eluting with 4-6 times of ethanol water solution with the volume fraction of 85% -95% of the column volume;
D. mixing the eluates, concentrating to 1/3-1/6 of the original weight to obtain the extracts of the components;
E. mixing the extracts according to the weight components to obtain the peach gum.
Example 3
The embodiment relates to peach gum capable of brightening skin, which comprises the following components in percentage by weight; peach resin extract: 64.92 parts; dendrobium officinale extract: 0.08 parts; pullulanase polysaccharide: 13 parts; tremella extract: 13 parts; 8 parts of trehalose; 0.1 part of 1, 2-hexanediol and 0.1 part of phenoxyethanol, and glycerin: 0.8 parts.
The preparation method comprises the following steps:
A. respectively crushing and sieving peach resin and dendrobium candidum, adding ethanol, and reflux-extracting for 4-8 hours at 50-100 ℃ with the weight-volume ratio of feed liquid being 1:5-50;
B. filtering the extractive solution, and vacuum concentrating until no alcohol smell;
C. adding water to the concentrated solution prepared in the step B, then loading the concentrated solution on a macroporous resin column or a polyamide resin column, eluting with 3-5 times of water, eluting with 4-6 times of ethanol water solution with the volume fraction of 30% -45% of the column volume, eluting with 3-5 times of ethanol water solution with the volume fraction of 50% -75% of the column volume, and eluting with 4-6 times of ethanol water solution with the volume fraction of 85% -95% of the column volume;
D. mixing the eluates, concentrating to 1/3-1/6 of the original weight to obtain the extracts of the components;
E. mixing the extracts according to the weight components to obtain the peach gum.
Example 4 Patch test
The experimental method comprises the following steps: the skin patch test was performed after preparing a cream containing 20% peach gum extract, and the skin patch parts were observed at 24h and 48h after the patch, respectively, and the specific results are shown in fig. 1.
FIG. 1 shows a peach gum prepared by the preparation method of example 1, wherein the peach gum is prepared as a cream with a mass percentage of 20% (the peach gum is prepared by the preparation method of example 1, but it is conceivable that other preparation methods of other embodiments can be used to obtain peach gum, and have the same efficacy), and a skin patch test is performed, wherein (a) is a 24-hour skin patch site case; (b) is a 48h skin patch test.
According to the skin response grading criteria of the skin closed patch test of table 1 below, it can be seen that the cream is safe and non-irritating when the cream contains 20% by mass.
Table 1.
Example 5 anti-inflammatory test
The experimental method comprises the following steps: skin allergy was tested using a histamine solution of 4% by mass; FIGS. 2 to 7 show anti-inflammatory tests using peach gum solutions with different mass percentages for 0 to 30min, wherein FIG. 2 shows anti-inflammatory tests using peach gum with an addition of 0 mass percentage, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 3 shows an anti-inflammatory test using peach gum with an added mass percent of 1%, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 4 shows the anti-inflammatory test with the addition of 3% by mass of peach gum, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 5 shows the anti-inflammatory test with the addition of peach gum at 5% by mass, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 6 shows an anti-inflammatory test with the addition of 10% by mass peach gum, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min;
FIG. 7 shows the anti-inflammatory test by adding 20% by mass of peach gum, wherein (a) is skin condition at 0min, (b) is skin condition at 10min, and (c) is skin condition at 30 min.
As can be seen from fig. 2 to 7, the peach gum solutions at the respective mass percentages have no anti-inflammatory effect.
Example 6, moisturizing test:
1. in vitro moisturizing test:
the experimental method comprises the following steps:
marking the beaker, drying in a drying oven at 105 ℃ to constant weight, and weighing after the beaker is cooled to room temperature, wherein the weight is counted as m 1 ；
Weighing appropriate amount of peach gum polysaccharide gum prepared to various concentrations to make the liquid surface just drop out of the bottle bottom, and recording as m 2 (weighing flask + sample);
the beaker with the sample was placed in a humidistat (supersaturated solution of calcium chloride) with a humidity of about 30%, weighed after 1h, 3h, 5h, 7h, 24h, respectively, and the weight of the sample at that time was m 3 。
Moisture retention= (m) 3 -m 1 )/(m 2- m 1 ) X 100% and higher values of the moisture retention indicate better moisture retention of the corresponding product.
The test result image is shown in fig. 8, in which curve I represents the moisture retention rate of the peach gum solution at 0% by mass, curve II represents the moisture retention rate of the peach gum solution at 1% by mass, curve III represents the moisture retention rate of the peach gum solution at 5% by mass, curve IV represents the moisture retention rate of the peach gum solution at 25% by mass, curve V represents the moisture retention rate of the peach gum solution at 10% by mass, and curve VI represents the moisture retention rate of the peach gum solution at 50% by mass.
2. Percutaneous moisturizing test
The experimental method comprises the following steps: firstly measuring the skin moisture content in an arm without applying the cream, then respectively taking 1g of the cream added with the peach gum with each concentration, applying the cream to the arm for measurement, respectively measuring the skin moisture content after 1h, 2h and 4h, and finally calculating the skin moisture content change rate.
The final test results are shown in fig. 9, wherein the column I adopts a blank matrix, the column II adopts a cream with an additive mass percentage of 2%, and the column III adopts a cream with an additive mass percentage of 5%. As can be seen from fig. 9, the peach gum can significantly improve the moisture retention and the skin moisture content.
The foregoing describes specific embodiments of the present invention. It is to be understood that the invention is not limited to the particular embodiments described above, and that various changes and modifications may be made by one skilled in the art within the scope of the claims without affecting the spirit of the invention.
Claims (9)
1. The peach resin polysaccharide gum capable of brightening skin is characterized by comprising the following components in parts by weight:
59.95-73 parts of peach resin extract;
0.05-1 part of dendrobium candidum extract;
10-15 parts of pullulanase polysaccharide;
10-15 parts of tremella extract;
1-10 parts of trehalose;
the preparation method of the peach gum comprises the following steps:
A. respectively crushing and sieving peach resin, dendrobium candidum and tremella, adding ethanol, and carrying out reflux extraction for 4-8 hours at 50-100 ℃ with the weight-volume ratio of feed liquid being 1:5-50;
B. filtering the extractive solution, and vacuum concentrating until no alcohol smell;
C. adding water to the concentrated solution prepared in the step B, then loading the concentrated solution on a macroporous resin column or a polyamide resin column, eluting with 3-5 times of water, eluting with 4-6 times of ethanol water solution with the volume fraction of 30% -45% of the column volume, eluting with 3-5 times of ethanol water solution with the volume fraction of 50% -75% of the column volume, and eluting with 4-6 times of ethanol water solution with the volume fraction of 85% -95% of the column volume;
D. mixing the eluates, concentrating to 1/3-1/6 of the original weight to obtain peach resin extract, dendrobium candidum extract and tremella extract;
E. mixing the peach resin extract, the dendrobium candidum extract, the pullulanase polysaccharide, the tremella extract and the trehalose according to parts by weight to obtain the peach resin polysaccharide gum.
2. The peach gum according to claim 1, wherein the peach gum further comprises water, glycerin, 1, 2-hexanediol, and phenoxyethanol.
3. The peach gum according to claim 1, wherein the peach resin is produced from Guizhou water.
4. The peach gum according to claim 1, wherein in step a, the ethanol is absolute ethanol.
5. The peach gum according to claim 1, wherein in step B, the vacuum is less than 0.1MPa.
6. Use of the peach gum according to any one of claims 1-5 for the preparation of skin care cosmetics.
7. The use according to claim 6, wherein the skin care cosmetic is selected from the group consisting of: moisturizing skin care cosmetics or antioxidant aging cosmetics.
8. The use according to claim 6, wherein the skin care cosmetic is in a form selected from the group consisting of cream, lotion, pack, gel, essence, facial cleanser and body wash.
9. The use according to claim 6, wherein the peach gum is 1% -10% of the total weight of the skin care cosmetic.
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| JP2013067594A (en) * | 2011-09-26 | 2013-04-18 | Nippon Fine Chem Co Ltd | Cosmetic containing prunus persica gum |
| CN105193655A (en) * | 2015-09-25 | 2015-12-30 | 斐丝肌(上海)商贸有限公司 | Composite with efficacies of water locking and moisturizing, face mask and face mask preparation method |
| CN106265339A (en) * | 2016-09-14 | 2017-01-04 | 叶树林 | A kind of six hours high-efficiency moisturizing compositions and preparation thereof and application |
| CN107496231A (en) * | 2017-08-28 | 2017-12-22 | 广州市馨雨化妆品有限公司 | A kind of skin care compositions and preparation method thereof |
| CN110464682A (en) * | 2018-05-10 | 2019-11-19 | 北京东方淼森生物科技有限公司 | A kind of peach gum composition, preparation method and application |
| CN110464691A (en) * | 2018-05-10 | 2019-11-19 | 北京东方淼森生物科技有限公司 | A kind of peach gum composition and its application |
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Patent Citations (6)
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| JP2013067594A (en) * | 2011-09-26 | 2013-04-18 | Nippon Fine Chem Co Ltd | Cosmetic containing prunus persica gum |
| CN105193655A (en) * | 2015-09-25 | 2015-12-30 | 斐丝肌(上海)商贸有限公司 | Composite with efficacies of water locking and moisturizing, face mask and face mask preparation method |
| CN106265339A (en) * | 2016-09-14 | 2017-01-04 | 叶树林 | A kind of six hours high-efficiency moisturizing compositions and preparation thereof and application |
| CN107496231A (en) * | 2017-08-28 | 2017-12-22 | 广州市馨雨化妆品有限公司 | A kind of skin care compositions and preparation method thereof |
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