CN112400871A - Isothiazolinone compound soluble powder and preparation process thereof - Google Patents
Isothiazolinone compound soluble powder and preparation process thereof Download PDFInfo
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- CN112400871A CN112400871A CN202011367035.0A CN202011367035A CN112400871A CN 112400871 A CN112400871 A CN 112400871A CN 202011367035 A CN202011367035 A CN 202011367035A CN 112400871 A CN112400871 A CN 112400871A
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- Prior art keywords
- isothiazolinone
- compound
- mixture
- polymer
- mixing
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- -1 Isothiazolinone compound Chemical class 0.000 title claims abstract description 37
- 239000000843 powder Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title abstract description 17
- 239000000203 mixture Substances 0.000 claims abstract description 62
- 238000002156 mixing Methods 0.000 claims abstract description 26
- 229920000642 polymer Polymers 0.000 claims abstract description 26
- 239000003381 stabilizer Substances 0.000 claims abstract description 22
- VUWCWMOCWKCZTA-UHFFFAOYSA-N 1,2-thiazol-4-one Chemical class O=C1CSN=C1 VUWCWMOCWKCZTA-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000006184 cosolvent Substances 0.000 claims abstract description 18
- 239000002904 solvent Substances 0.000 claims abstract description 17
- 229940079593 drug Drugs 0.000 claims abstract description 15
- 239000003814 drug Substances 0.000 claims abstract description 15
- 230000003381 solubilizing effect Effects 0.000 claims abstract description 14
- 229940125904 compound 1 Drugs 0.000 claims abstract description 13
- 229940125782 compound 2 Drugs 0.000 claims abstract description 13
- 239000000463 material Substances 0.000 claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 10
- 238000003756 stirring Methods 0.000 claims description 20
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 12
- 229920000858 Cyclodextrin Polymers 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 claims description 10
- DMSMPAJRVJJAGA-UHFFFAOYSA-N benzo[d]isothiazol-3-one Chemical compound C1=CC=C2C(=O)NSC2=C1 DMSMPAJRVJJAGA-UHFFFAOYSA-N 0.000 claims description 9
- 238000007873 sieving Methods 0.000 claims description 8
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 6
- 239000001508 potassium citrate Substances 0.000 claims description 6
- 229960002635 potassium citrate Drugs 0.000 claims description 6
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 claims description 6
- 235000011082 potassium citrates Nutrition 0.000 claims description 6
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 6
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 5
- OKPNGJYDFAMSHL-UHFFFAOYSA-N 2-methyl-3h-1,2-benzothiazole 1-oxide Chemical compound C1=CC=C2S(=O)N(C)CC2=C1 OKPNGJYDFAMSHL-UHFFFAOYSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
- CTKXFMQHOOWWEB-UHFFFAOYSA-N Ethylene oxide/propylene oxide copolymer Chemical compound CCCOC(C)COCCO CTKXFMQHOOWWEB-UHFFFAOYSA-N 0.000 claims description 5
- 239000001116 FEMA 4028 Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 5
- 229930195725 Mannitol Natural products 0.000 claims description 5
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims description 5
- 229920002472 Starch Polymers 0.000 claims description 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 5
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 5
- 229960004853 betadex Drugs 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 5
- 239000008101 lactose Substances 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- 229920001993 poloxamer 188 Polymers 0.000 claims description 5
- 229940044519 poloxamer 188 Drugs 0.000 claims description 5
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 5
- 235000011056 potassium acetate Nutrition 0.000 claims description 5
- 235000011181 potassium carbonates Nutrition 0.000 claims description 5
- 239000004302 potassium sorbate Substances 0.000 claims description 5
- 235000010241 potassium sorbate Nutrition 0.000 claims description 5
- 229940069338 potassium sorbate Drugs 0.000 claims description 5
- 239000001632 sodium acetate Substances 0.000 claims description 5
- 235000017281 sodium acetate Nutrition 0.000 claims description 5
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 5
- 239000004299 sodium benzoate Substances 0.000 claims description 5
- 235000010234 sodium benzoate Nutrition 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- 235000017550 sodium carbonate Nutrition 0.000 claims description 5
- 239000001509 sodium citrate Substances 0.000 claims description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 5
- 235000011083 sodium citrates Nutrition 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- 239000005720 sucrose Substances 0.000 claims description 5
- 229920002521 macromolecule Polymers 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 29
- 239000003651 drinking water Substances 0.000 abstract description 24
- 235000020188 drinking water Nutrition 0.000 abstract description 24
- 244000144977 poultry Species 0.000 abstract description 17
- 230000007547 defect Effects 0.000 abstract description 6
- 238000003860 storage Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 3
- 239000012752 auxiliary agent Substances 0.000 abstract description 2
- 239000008399 tap water Substances 0.000 abstract description 2
- 235000020679 tap water Nutrition 0.000 abstract description 2
- 238000004090 dissolution Methods 0.000 abstract 1
- 235000013594 poultry meat Nutrition 0.000 description 16
- 238000004806 packaging method and process Methods 0.000 description 12
- 238000009395 breeding Methods 0.000 description 8
- 230000001488 breeding effect Effects 0.000 description 8
- 241000287828 Gallus gallus Species 0.000 description 7
- 235000013330 chicken meat Nutrition 0.000 description 7
- 241000195493 Cryptophyta Species 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000000746 purification Methods 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- DHNRXBZYEKSXIM-UHFFFAOYSA-N chloromethylisothiazolinone Chemical compound CN1SC(Cl)=CC1=O DHNRXBZYEKSXIM-UHFFFAOYSA-N 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 244000144992 flock Species 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000010985 leather Substances 0.000 description 2
- 244000144972 livestock Species 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 229940100555 2-methyl-4-isothiazolin-3-one Drugs 0.000 description 1
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
- 229920003080 Povidone K 25 Polymers 0.000 description 1
- 229920003081 Povidone K 30 Polymers 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940124350 antibacterial drug Drugs 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-M bromate Inorganic materials [O-]Br(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-M 0.000 description 1
- SXDBWCPKPHAZSM-UHFFFAOYSA-N bromic acid Chemical compound OBr(=O)=O SXDBWCPKPHAZSM-UHFFFAOYSA-N 0.000 description 1
- 239000000498 cooling water Substances 0.000 description 1
- 150000001879 copper Chemical class 0.000 description 1
- 239000010730 cutting oil Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000003640 drug residue Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- MGIYRDNGCNKGJU-UHFFFAOYSA-N isothiazolinone Chemical compound O=C1C=CSN1 MGIYRDNGCNKGJU-UHFFFAOYSA-N 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910001960 metal nitrate Inorganic materials 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000002445 nipple Anatomy 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
- 229940093429 polyethylene glycol 6000 Drugs 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 238000007639 printing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/12—Powders or granules
- A01N25/14—Powders or granules wettable
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F1/00—Treatment of water, waste water, or sewage
- C02F1/50—Treatment of water, waste water, or sewage by addition or application of a germicide or by oligodynamic treatment
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2103/00—Nature of the water, waste water, sewage or sludge to be treated
- C02F2103/02—Non-contaminated water, e.g. for industrial water supply
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2303/00—Specific treatment goals
- C02F2303/04—Disinfection
-
- C—CHEMISTRY; METALLURGY
- C02—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F—TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
- C02F2303/00—Specific treatment goals
- C02F2303/20—Prevention of biofouling
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Toxicology (AREA)
- Hydrology & Water Resources (AREA)
- Environmental & Geological Engineering (AREA)
- Water Supply & Treatment (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention provides soluble isothiazolinone compound powder which is prepared from the following components in parts by weight: main drugs: 2.5-20 g of isothiazolinone compounds, 2.5-20 g of cosolvent and 6-30 g of polymer solubilizing and stabilizing agent composition, wherein the polymer solubilizing and stabilizing agent composition is prepared by mixing a polymer compound 1 and a polymer compound 2 according to the weight ratio of 2: 1 proportion, 50.0-89.0 parts of auxiliary materials, and the total amount of the mixed components is 100 g; the invention screens out proper auxiliary agents such as cosolvent, polymer solubilizer, stabilizer and the like, and the obtained finished product can be quickly dissolved in tap water when in use and can be used for purifying poultry drinking water pipelines; the preparation process is simple and convenient, the quality is controllable, and the safety is high; the isothiazolinone compound soluble powder has stable property in the three-year storage process, has good stability in one week of water dissolution, and overcomes the defect that the conventional solution of the isothiazolinone compound is unstable.
Description
Technical Field
The invention relates to the technical field of veterinary drugs, in particular to soluble isothiazolinone compound powder and a preparation process thereof.
Background
In various farms such as large-scale chicken farms, various substances such as a plurality of biofilms, dirt, drug residues and the like are often accumulated in water supply pipelines and water dispensers, and a large amount of pathogenic microorganisms such as bacteria, fungi, algae and the like are bred, so that the water tanks, waterlines and water dispensers are blocked, and the water dispensers cannot discharge water or discharge water too slowly, so that the livestock and poultry and the like cannot normally drink water. In addition, unclean pipelines can lead livestock and poultry to be forced to drink polluted water, which can cause chicken flocks to get sick, thereby reducing the production performance and increasing the cost. Although the antibacterial drug can be used for chicken flocks to treat diseases such as chicken colibacillosis and the like, the problems of infection sources, mycoderm breeding in waterlines and the like are not solved. In order to solve the problem of pollution of drinking equipment and the waterline, the waterline must be cleaned frequently, which undoubtedly increases the labor intensity and the labor cost. In order to solve the pathogenic source of poultry radically, reduce morbidity, reduce the release of antibiotics and medicines and reduce the washing times and labor intensity of the waterline, the waterline can be kept clean by regular purification and maintenance of the waterline, and the method is undoubtedly the best selection measure. The waterline purification can eradicate intractable diarrhea caused by mass propagation of bacteria in the waterline, reduce the drug delivery in intestinal tracts, reduce the drug cost, make animals healthier, have better production performance, greatly reduce the labor cost and obviously improve the breeding benefit. Although the disinfectant can kill various microorganisms, most disinfectants have strong oxidizing property, irritation and corrosiveness, and are not suitable for being used for purifying a waterline regularly. The poultry industry urgently needs high-efficiency, safe and environment-friendly drinking water pipeline purifying medicines.
The isothiazolinone compounds are a general name of a series of compounds containing isothiazolinone, are novel broad-spectrum, efficient, safe and non-oxidizing bactericides, and have the characteristics of high biocidal efficiency, good compatibility, good degradability, low use cost and the like. The isothiazolinone compounds can generate a biocidal effect by breaking S-N bonds of proteins of bacteria and algae, and have strong inhibiting and killing effects on common bacteria, fungi, algae and the like. The method is widely applied to industries such as industrial circulating cooling water, oil fields, papermaking, pesticides, agriculture and forestry environmental protection, light industry and daily use chemicals, cutting oil, leather, printing ink, dye, leather making and the like, and solves a series of problems of mildew, fermentation, deterioration, emulsion breaking, odor generation and the like of organic products caused by breeding of microorganisms (fungi, bacteria, algae and the like). The isothiazolinone compounds are suitable for purifying poultry drinking water pipelines (such as automatic drinking equipment, a water tank, waterline nipples and automatic drinking water pipelines) due to the action characteristics, and can be periodically used for purifying the poultry drinking water equipment, the waterline and the like, so that the breeding of microorganisms in the drinking water pipelines can be greatly reduced, the cleanness and the sanitation of a drinking water system during the whole breeding period are ensured, biofilms and algae can not be generated, the water quality is kept clean, the drinking water is ensured to be clean, the occurrence of intractable diarrhea and intestinal diseases is reduced, the medication cost is reduced, the washing and cleaning times are reduced, the labor intensity is reduced, and the breeding benefit is improved. However, these compounds are insoluble in water and are unstable in water. The compound preparations of the invention currently used or disclosed in the patent are mainly liquid preparations, such as chloromethyl isothiazolinone/methyl isothiazolinone (CMIT/MIT) solution, Benzisothiazolinone (BIT) solution, etc., but the storage life is short (only 1 year), stabilizers (metal nitrate, formaldehyde, metal bromate, copper salt, etc.) are added, and the stabilizers have safety problems for poultry, and organic solvents and the like used for preparing the solution are not suitable for poultry drinking water lines.
Disclosure of Invention
The invention aims to overcome the prior defects and provide soluble isothiazolinone compound powder and a preparation process thereof, develops soluble isothiazolinone compound powder for purifying poultry drinking water pipelines and a preparation process thereof, develops a new compound preparation suitable for purifying poultry drinking water pipelines, fills in a market gap, develops a new compound preparation suitable for purifying poultry drinking water pipelines, can make up the defects of poor water solubility and no soluble solid preparation of the isothiazolinone compound, improves the water solubility and the stability of the isothiazolinone compound by adding a cosolvent, improves the water solubility and the stability of the isothiazolinone compound, is used for purifying drinking water equipment and pipelines by dissolving the isothiazolinone compound in water at present, is convenient to use, has good purification effect on drinking water systems, can reduce the disease of chickens, reduces the cleaning times and labor intensity, the breeding benefit is improved; the water-soluble polyurethane foam has good water solubility, stable property, low production and application cost and convenient packaging and transportation, and can effectively solve the problems in the background technology.
In order to achieve the above object, the present invention proposes: the soluble isothiazolinone compound powder is prepared from the following components: main drugs: 2.5-20 g of isothiazolinone compounds, 2.5-20 g of cosolvent and 6-30 g of polymer solubilizing and stabilizing agent composition, wherein the polymer solubilizing and stabilizing agent composition is prepared by mixing a polymer compound 1 and a polymer compound 2 according to the weight ratio of 2: 1 proportion, 50.0-89.0 auxiliary materials, and the total amount of the above components is 100 g.
Further, the main drug isothiazolinone compounds comprise: 4, 5-dichloro-2-methylisothiazolinone, benzisothiazolinone, 4, 5-dichloro-2-N-octyl isothiazolinone, N-methylbenzoisothiazolinone, N-N-octylbenzisothiazolinone and N-N-butylbenzisothiazolinone or a combination of a plurality of the same.
Further, the cosolvent is one or a combination of more selected from sodium acetate, potassium acetate, sodium benzoate, potassium sorbate, sodium citrate, potassium citrate, sodium carbonate and potassium carbonate.
Further, the high molecular compound 1 is one selected from polyethylene glycol 2000-6000, poloxamer 188 and hydroxypropyl methyl cellulose, and the high molecular compound 2 is one selected from PVP K15-K30, beta-cyclodextrin and hydroxypropyl cyclodextrin.
Further, the auxiliary materials are one or a combination of more of glucose, lactose, sucrose, mannitol, water-soluble starch, anhydrous sodium sulfate, sodium bicarbonate and auxiliary powder.
A preparation process of isothiazolinone compound soluble powder is characterized by comprising the following steps: the method comprises the following steps:
s1): firstly, mixing and stirring an isothiazolinone compound and a cosolvent uniformly to obtain a mixture A for later use;
s3): mixing the macromolecular compound 1 and the macromolecular compound 2 according to the weight ratio of 2: 1 proportion, and uniformly stirring to obtain a macromolecular solubilizing and stabilizing agent composition, namely a mixture B for later use;
s3): adding the mixture A into the mixture B, and uniformly stirring and mixing to obtain a mixture C for later use;
s4): adding the prepared mixture C into auxiliary materials, and uniformly stirring and mixing at the room temperature of 20-35 ℃ to obtain a mixture D for later use;
s4): and (4) sieving the prepared mixture D with a 60-80-mesh sieve, and subpackaging according to 100-1000 g to obtain a finished product.
Compared with the prior art, the invention has the beneficial effects that:
1. the invention screens out proper auxiliary agents such as cosolvent, polymer solubilizer, stabilizer and the like, and the obtained finished product can be quickly dissolved in tap water when in use and can be used for purifying poultry drinking water pipelines; the preparation method is simple and convenient, and has controllable quality and high safety.
2. The isothiazolinone compound soluble powder has stable quality in the process of three-year storage, has good stability in one week after being dissolved in water, overcomes the defect of instability of conventional solutions of the isothiazolinone compound, avoids the toxicity of a high-concentration stabilizer added to animals, is convenient to package, store and transport, and is suitable for purification treatment of poultry drinking water pipelines and drinking water lines.
3. The isothiazolinone compound soluble powder is safe to chickens and has no obvious toxic or side effect.
4. The invention develops a new isothiazolinone compound formulation suitable for purifying poultry drinking water pipelines, can make up the defects that the isothiazolinone compound has poor water solubility and cannot be mixed with water for administration, a solution used in a conventional process is unstable, a used solvent and a used stabilizer have toxicity to animals, and the storage and transportation are inconvenient, improves the water solubility of the isothiazolinone compound by adding a cosolvent, improves the stability of the isothiazolinone compound by adding a stabilizer, can be used for purifying poultry drinking water pipelines by dissolving the isothiazolinone compound in normal water, can greatly reduce the residual pathogens and algae in drinking water facilities, reduces the chances of causing the infection of the animals, reduces the pipeline blockage and the cleaning times of drinking water lines, and has good and stable water solubility, low production and application costs, convenient use, and convenient packaging and transportation.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The invention provides the following technical scheme:
the first embodiment is as follows:
the soluble isothiazolinone compound powder is prepared from the following components: main drugs: 2.5-20 g of isothiazolinone compounds, 2.5-20 g of cosolvent and 6-30 g of polymer solubilizing and stabilizing agent composition, wherein the polymer solubilizing and stabilizing agent composition is prepared by mixing a polymer compound 1 and a polymer compound 2 according to the weight ratio of 2: 1 proportion, 50.0-89.0 auxiliary materials, and the total amount of the above components is 100 g.
Further, the main drug isothiazolinone compounds comprise: 4, 5-dichloro-2-methylisothiazolinone, benzisothiazolinone, 4, 5-dichloro-2-N-octyl isothiazolinone, N-methylbenzoisothiazolinone, N-N-octylbenzisothiazolinone and N-N-butylbenzisothiazolinone or a combination of a plurality of the same.
Further, the cosolvent is one or a combination of more selected from sodium acetate, potassium acetate, sodium benzoate, potassium sorbate, sodium citrate, potassium citrate, sodium carbonate and potassium carbonate.
Further, the high molecular compound 1 is one selected from polyethylene glycol 2000-6000, poloxamer 188 and hydroxypropyl methyl cellulose, and the high molecular compound 2 is one selected from PVP K15-K30, beta-cyclodextrin and hydroxypropyl cyclodextrin.
Further, the auxiliary materials are one or a combination of more of glucose, lactose, sucrose, mannitol, water-soluble starch, anhydrous sodium sulfate, sodium bicarbonate and auxiliary powder.
A preparation process of isothiazolinone compound soluble powder is characterized by comprising the following steps: the method comprises the following steps:
s1): firstly, stirring and uniformly mixing benzisothiazolinone and sodium carbonate to obtain a mixture A for later use;
s2): adding polyethylene glycol 6000 into PVP K30, stirring and mixing uniformly to obtain a mixture B for later use;
s3): uniformly stirring and mixing the mixture A and the mixture B to obtain a mixture C for later use;
s4): adding the prepared mixture C into anhydrous sodium sulfate, and stirring and mixing uniformly at room temperature to obtain a mixture D for later use;
s5): and directly sieving the prepared mixture D or sieving the mixture D after crushing, wherein a sieve mesh adopts a sieve with 60-80 meshes, packaging the mixture D into packaging bags according to 100g, and sealing the packaging bags to obtain the finished product.
Example two:
the soluble isothiazolinone compound powder is prepared from the following components: main drugs: 2.5-20 g of isothiazolinone compounds, 2.5-20 g of cosolvent and 6-30 g of polymer solubilizing and stabilizing agent composition, wherein the polymer solubilizing and stabilizing agent composition is prepared by mixing a polymer compound 1 and a polymer compound 2 according to the weight ratio of 2: 1 proportion, 50.0-89.0 auxiliary materials, and the total amount of the above components is 100 g.
Further, the main drug isothiazolinone compounds comprise: 4, 5-dichloro-2-methylisothiazolinone, benzisothiazolinone, 4, 5-dichloro-2-N-octyl isothiazolinone, N-methylbenzoisothiazolinone, N-N-octylbenzisothiazolinone and N-N-butylbenzisothiazolinone or a combination of a plurality of the same.
Further, the cosolvent is one or a combination of more selected from sodium acetate, potassium acetate, sodium benzoate, potassium sorbate, sodium citrate, potassium citrate, sodium carbonate and potassium carbonate.
Further, the high molecular compound 1 is one selected from polyethylene glycol 2000-6000, poloxamer 188 and hydroxypropyl methyl cellulose, and the high molecular compound 2 is one selected from PVP K15-K30, beta-cyclodextrin and hydroxypropyl cyclodextrin.
Further, the auxiliary materials are one or a combination of more of glucose, lactose, sucrose, mannitol, water-soluble starch, anhydrous sodium sulfate, sodium bicarbonate and auxiliary powder.
A preparation process of isothiazolinone compound soluble powder is characterized by comprising the following steps: the method comprises the following steps:
s1): uniformly stirring and mixing 4, 5-dichloro-2-methylisothiazolinone and potassium citrate to obtain a mixture A for later use;
s2): adding polyethylene glycol 4000 into PVP K15, and stirring and mixing uniformly to obtain a mixture B for later use;
s3): uniformly stirring and mixing the mixture A and the mixture B to obtain a mixture C for later use;
s4): adding the prepared mixture C into sodium bicarbonate, and stirring and mixing uniformly at room temperature to obtain a mixture D for later use;
s5): and directly sieving the prepared mixture D or sieving the mixture D after crushing, wherein a sieve mesh adopts a sieve with 60-80 meshes, packaging the mixture D into packaging bags according to 100g, and sealing the packaging bags to obtain the finished product.
Example three:
the soluble isothiazolinone compound powder is prepared from the following components: main drugs: 2.5-20 g of isothiazolinone compounds, 2.5-20 g of cosolvent and 6-30 g of polymer solubilizing and stabilizing agent composition, wherein the polymer solubilizing and stabilizing agent composition is prepared by mixing a polymer compound 1 and a polymer compound 2 according to the weight ratio of 2: 1 proportion, 50.0-89.0 auxiliary materials, and the total amount of the above components is 100 g.
Further, the main drug isothiazolinone compounds comprise: 4, 5-dichloro-2-methylisothiazolinone, benzisothiazolinone, 4, 5-dichloro-2-N-octyl isothiazolinone, N-methylbenzoisothiazolinone, N-N-octylbenzisothiazolinone and N-N-butylbenzisothiazolinone or a combination of a plurality of the same.
Further, the cosolvent is one or a combination of more selected from sodium acetate, potassium acetate, sodium benzoate, potassium sorbate, sodium citrate, potassium citrate, sodium carbonate and potassium carbonate.
Further, the high molecular compound 1 is one selected from polyethylene glycol 2000-6000, poloxamer 188 and hydroxypropyl methyl cellulose, and the high molecular compound 2 is one selected from PVP K15-K30, beta-cyclodextrin and hydroxypropyl cyclodextrin.
Further, the auxiliary materials are one or a combination of more of glucose, lactose, sucrose, mannitol, water-soluble starch, anhydrous sodium sulfate, sodium bicarbonate and auxiliary powder.
A preparation process of isothiazolinone compound soluble powder is characterized by comprising the following steps: the method comprises the following steps:
s1): firstly, stirring and uniformly mixing benzisothiazolinone and potassium carbonate to obtain a mixture A for later use;
s2): adding polyethylene glycol 2000 into PVP K25, stirring and mixing uniformly to obtain a mixture B for later use;
s3): uniformly stirring and mixing the mixture A and the mixture B to obtain a mixture C for later use;
s4): adding the prepared mixture C into the auxiliary beauty powder, and stirring and mixing uniformly at room temperature to obtain a mixture D for later use;
s5): and directly sieving the prepared mixture D or sieving the mixture D after crushing, wherein a sieve mesh adopts a sieve with 60-80 meshes, packaging the mixture D into packaging bags according to 100g, and sealing the packaging bags to obtain the finished product.
The invention has the advantages that: the invention develops a new formulation of the compound suitable for purifying poultry drinking water pipelines, can make up the defects of poor water solubility and no soluble solid preparation of isothiazolinone compounds, improves the water solubility by adding cosolvent, improves the water solubility and the stability by adding dispersant and stabilizer, is used for purifying drinking water equipment and pipelines at present, is convenient to use, has good purification effect on drinking water systems, can reduce the disease of chickens, reduces the cleaning times and labor intensity, and improves the breeding benefit. It has good water solubility, stable property, low production and application cost and convenient packaging and transportation.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. An isothiazolinone compound soluble powder, which is characterized in that: the isothiazolinone compound soluble powder is prepared from the following components: main drugs: 2.5-20 g of isothiazolinone compounds, 2.5-20 g of cosolvent and 6-30 g of polymer solubilizing and stabilizing agent composition, wherein the polymer solubilizing and stabilizing agent composition is prepared by mixing a polymer compound 1 and a polymer compound 2 according to the weight ratio of 2: 1 proportion, 50.0-89.0 auxiliary materials, and the total amount of the above components is 100 g.
2. The soluble powder of isothiazolinone compounds according to claim 1, characterized in that: the main drug isothiazolinone compounds comprise: 4, 5-dichloro-2-methylisothiazolinone, benzisothiazolinone, 4, 5-dichloro-2-N-octyl isothiazolinone, N-methylbenzoisothiazolinone, N-N-octylbenzisothiazolinone and N-N-butylbenzisothiazolinone or a combination of a plurality of the same.
3. The soluble powder of isothiazolinone compounds according to claim 1, characterized in that: the cosolvent is one or more selected from sodium acetate, potassium acetate, sodium benzoate, potassium sorbate, sodium citrate, potassium citrate, sodium carbonate, and potassium carbonate.
4. The soluble powder of isothiazolinone compounds according to claim 1, characterized in that: the high molecular compound 1 is one selected from polyethylene glycol 2000-6000, poloxamer 188 and hydroxypropyl methyl cellulose, and the high molecular compound 2 is one selected from PVP K15-K30, beta-cyclodextrin and hydroxypropyl cyclodextrin.
5. The soluble powder of isothiazolinone compounds according to claim 1, characterized in that: the auxiliary materials are selected from one or more of glucose, lactose, sucrose, mannitol, water-soluble starch, anhydrous sodium sulfate, sodium bicarbonate and auxiliary powder.
6. The process for preparing soluble powder of isothiazolinone compounds according to claim 1, which is characterized by comprising the following steps: the method comprises the following steps:
s1): firstly, mixing and stirring an isothiazolinone compound and a cosolvent uniformly to obtain a mixture A for later use;
s3): mixing the macromolecular compound 1 and the macromolecular compound 2 according to the weight ratio of 2: 1 proportion, and uniformly stirring to obtain a macromolecular solubilizing and stabilizing agent composition, namely a mixture B for later use;
s3): adding the mixture A into the mixture B, and uniformly stirring and mixing to obtain a mixture C for later use;
s4): adding the prepared mixture C into auxiliary materials, and uniformly stirring and mixing at the room temperature of 20-35 ℃ to obtain a mixture D for later use;
s4): and (4) sieving the prepared mixture D with a 60-80-mesh sieve, and subpackaging according to 100-1000 g to obtain a finished product.
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| JPH09110843A (en) * | 1995-10-11 | 1997-04-28 | Takeda Chem Ind Ltd | Composition containing isothiazolone-based compound and stabilization or isothiazolone-based compound |
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| CN101843250A (en) * | 2010-06-21 | 2010-09-29 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing compound containing isothiazolin-ketone and kasugamycin |
| CN107397719A (en) * | 2017-08-16 | 2017-11-28 | 洛阳市兽药厂 | A kind of livestock and poultry Omeprazole soluble powder and its preparation technology |
| CN109125253A (en) * | 2018-10-19 | 2019-01-04 | 洛阳市兽药厂 | The preparation process of one boar uterus benzoisothiazolinone temperature sensitive type in-situ gel |
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| JPH09110843A (en) * | 1995-10-11 | 1997-04-28 | Takeda Chem Ind Ltd | Composition containing isothiazolone-based compound and stabilization or isothiazolone-based compound |
| JP2007230892A (en) * | 2006-02-28 | 2007-09-13 | Nippon Soda Co Ltd | Water-soluble preparation containing isothiazolone compound and method for stabilizing isothiazolone compound |
| CN101843250A (en) * | 2010-06-21 | 2010-09-29 | 陕西上格之路生物科学有限公司 | Agricultural sterilizing compound containing isothiazolin-ketone and kasugamycin |
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