CN111939203B - Traditional Chinese medicine ointment preparation for treating diabetic foot and preparation method thereof - Google Patents

Abstract

The invention discloses a traditional Chinese medicine ointment preparation for treating diabetic foot and a preparation method thereof. The traditional Chinese medicine ointment preparation is prepared from the following traditional Chinese medicine raw materials: 4-5 parts of lithospermum, 2-3 parts of raw gardenia kernel, 1-1.5 parts of coptis chinensis, 2-3 parts of fructus forsythiae, 2-3 parts of angelica sinensis, 7-9 parts of beeswax and 74-82 parts of sesame oil. The invention has the functions of easing pain, activating blood, diminishing inflammation, resisting bacteria, expanding blood vessels, improving microcirculation, activating stem cell active factors, promoting the repair of hair follicle capillary vessels and nervous systems, removing necrotic tissues, promoting granulation and promoting the repair and healing of diabetic feet. The invention also has good effect on treating bedsore, difficult ulcer, burn, scald and cold injury. The invention is a Chinese medicinal ointment preparation with simple production process, controllable quality, convenient use, safety and effectiveness.

Description

Traditional Chinese medicine ointment preparation for treating diabetic foot and preparation method thereof

Technical Field

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine ointment preparation containing animal and plant derived medical medicines for treating diabetic foot and a preparation method thereof.

Background

Since the reform and the development of China, with the development of social productivity, the physical labor of people is gradually reduced, the living standard is continuously improved, and the incidence of diabetes in China is increased dramatically. With the increase of patients with diabetes, the number of three complications (eye disease, nephropathy, and foot disease) is rapidly increasing. According to the statistics of the national health and construction department: the number of diabetes mellitus attacks reaches about 1.14 hundred million in China, the attacks tend to be younger, and the number of the attacks is continuously increased. Diabetic feet account for about 15% of diabetic patients, with amputation rates of about 17 times that of non-diabetic feet. The diabetic foot is mainly caused by the combined action of three factors, namely peripheral vascular lesion of lower limbs, peripheral neuropathy and wound infection. The diabetic foot patients generally have the defects of age, high blood pressure, high glycated hemoglobin, poor oxygen carrying capacity of erythrocytes, high blood viscosity, vascular sclerosis, embrittlement and thickening, reduced cell deformability, lowered pulsation of lower limb arteries, thrombus formation of peripheral capillaries or blood vessel blockage due to speckles, insufficient blood supply and oxygen supply, malnutrition, metabolic disorder and the like. Diabetes is called as diabetes in traditional Chinese medicine, namely diseases of lung, spleen and kidney. Patients often show symptoms such as polydipsia, polyphagia, diuresis, fatigue, insomnia, dry lower limbs, limping during walking, and blisters at toes. If the diabetic suffers from burn, scald or trauma, the diabetic is very easy to suffer from comprehensive infection, various bacteria multiply greatly, especially anaerobic bacteria rapidly multiply, the infection speed is accelerated, the condition of the wound surface is worsened, the wound surface can not be cured for a long time until the wound surface is broken, and finally only amputation is carried out, wherein 85 percent of the wound surface is caused by improper treatment of small-area ulcer. So far, no effective treatment technical scheme and means for treating the diabetic foot are summarized at home and abroad. At present, western medicine mainly uses antibiotics to resist infection, and adopts means such as medicines, operations, local debridement, novel external application materials, stem cell transplantation, high pressure oxygen and the like, but the problem of healing of the wound surface of the diabetic foot cannot be fundamentally solved.

The inventor continuously tests, analyzes, summarizes, innovates and perfects the original secret recipe on the basis of ascertaining the causes of the diabetic foot. The invention is formed: a Chinese medicinal ointment for treating diabetic foot and its preparation method are provided. The inventor obtains good curative effect by comprehensively treating the diabetic foot.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine ointment preparation for relieving the illness state of a patient, promoting wound healing, reducing amputation rate and improving the life quality of the patient and a preparation method thereof. The invention adopts Chinese medicinal materials consisting of plants and animals with different properties, extracts effective components thereof by using a unique production and processing process, and plays the overall function to achieve the best curative effect: the traditional Chinese medicine composition has the advantages of diminishing inflammation, resisting bacteria, improving microcirculation, promoting blood circulation, relieving pain, expanding blood vessels, activating stem cell active factors, promoting repair of hair follicle capillary vessels and nervous systems, removing necrotic tissues, promoting granulation and accelerating wound healing, is non-toxic, non-allergic, non-irritant and free of side effects, and is worthy of clinical popularization and application.

In order to achieve the purpose, the invention provides the following technical scheme: a traditional Chinese medicine ointment preparation for treating diabetic foot is characterized by being prepared from the following traditional Chinese medicine raw materials: 4-5 parts of lithospermum, 2-3 parts of raw gardenia kernel, 1-1.5 parts of coptis chinensis, 2-3 parts of fructus forsythiae, 2-3 parts of angelica sinensis, 7-9 parts of beeswax and 74-82 parts of sesame oil. Specifically, each serving may be 100 grams.

The preparation method of the traditional Chinese medicine ointment preparation for treating diabetic foot comprises the following steps:

the method comprises the following steps: removing dust from radix Arnebiae, fructus Gardeniae, Coptidis rhizoma, fructus forsythiae and radix Angelicae sinensis;

step two: pulverizing radix Arnebiae, and cutting radix Angelicae sinensis into pieces;

step three: placing radix Arnebiae, fructus Gardeniae, Coptidis rhizoma, fructus forsythiae, and radix Angelicae sinensis into a container, adding oleum Sesami, and soaking for 120 hr to obtain an oil-medicine mixture;

step four: soaking oleum Sesami in the mixture of the above materials, decocting for 25-30 min, stopping heating for 15 min, decocting for 30-35 min, stopping heating for 15 min, and decocting for 20 min;

step five: filtering the oil-medicine mixture obtained in the step four by using sterile gauze, and squeezing by using a squeezer to obtain a liquid medicine;

step six: pouring the liquid medicine into a container, heating to a boiling point, adding the cut beeswax, and uniformly stirring until the beeswax is completely dissolved to obtain a medicament;

step seven: cooling the medicinal preparation to obtain unguent;

step eight: packaging and storing the ointment.

The pharmacological mechanism of the main components of the medicinal materials in the invention is as follows:

chinese angelica root: the smell of the medicine can relax muscles and tendons, promote blood circulation, expel pus and stop pain. The functional indications are as follows: various malignant sores, warming the middle-jiao to relieve pain, removing internal obstruction of blood, tonifying five internal organs, generating muscles, treating acute eczema, cutting all blood, breaking malignant blood, nourishing new blood, treating carbuncle and furuncle, expelling pus to relieve pain, tonifying blood and relieving heat and pain of feet. The main indications are as follows: malignant boil, ulcer, incised wound, harmonizing blood, tonifying blood and five zang organs.

Coptis chinensis: bitter, cold and nontoxic. The functional indications are as follows: hot air, eye pain, angular injury, bleeding, it is indicated for long-term heat in the five zang organs with pus and blood, to stop thirst and convulsions, to treat aphtha, five diseases with seven impairments, to stop night sweat, scabies, to stop bleeding by fleshy tissue, to clear heart orifice and to avoid bleeding. The main treatment is as follows: heat sores, diabetes, hyperhidrosis, frequent urination.

Lithospermum: bitter, cold and nontoxic. The functional indications are as follows: heart and abdomen pathogenic qi, five jaundice, tonify middle-jiao and qi, benefit nine orifices, lead to water passage, swelling and pain, and harmonize bone, treat infantile sore, activate blood and cool blood. The main treatment is as follows: malignant boil, carbuncle tinea, macula rash, and pox toxin.

Raw gardenia kernel: bitter, cold and nontoxic. The functional indications are as follows: the five internal pathogenic factors and the hot gas in the stomach are removed, the scabby scabies and the sores are removed, the heat-toxin wind is removed, the five kinds of yellow diseases are removed, the five stranguria is relieved, the chest, the heart, the large intestine and the large heat are relieved, and the heat is dissolved and detoxified by the brown. The main treatment is as follows: sores and ulcers, burn and scald in soup, scabby scabies and scabies.

Beeswax: sweet, slightly warm and nontoxic. The functional indications are as follows: mainly for diarrhea and pus blood, tonifying the middle-jiao, and curing incised wound, and after treating chronic diarrhea , it is white and dense, and can cure wound, chilblain on foot, shank shank ulcer caused by dog bite, and sore due to decoction and fire. It has complex components, and contains flavonoids, phenols, alcohols, acids, etc. as main components, and small amount of trace elements such as iron, cadmium, silicon, manganese, lead, tin, zinc, nickel, etc., vitamins, amino acids, carbohydrates, etc. Efficacy of beeswax: 1 has broad-spectrum antibacterial effect. 2, promoting the immune function of the organism. 3 improving microcirculation. 4 promoting the regeneration of body tissues. 5 relieving pain, removing toxic substance, and relieving inflammation.

Fructus forsythiae: bitter, mild and non-toxic. The functional indications are as follows: treating scrofula of mice fistula due to cold and heat, carbuncle, swelling and gall, accumulated heat and poison, freeing strangury, freeing small intestine, discharging pus, treating sore and furuncle, dissipating blood stasis and qi accumulation, purging heart fire and relieving swelling. The main treatment is as follows: hemorrhoids, sores and furuncles, and ulcers.

Sesame oil: sesame oil is also known as sesame oil. Sweet, cold and nontoxic. The functional indications are as follows: the traditional Chinese medicine has the effects of tonifying five internal organs, tonifying qi, growing muscle, filling marrow and brain, strengthening bones and muscles, treating golden sores, relieving pain, tonifying middle-jiao and qi, moistening five internal organs, chewing and coating infantile head sores, decocting and bathing malignant sores, and treating female genital sores, and has great effects. The traditional Chinese medicine composition contains a large amount of alcohol substances, can extract active ingredients of the medicines by soaking and decocting the traditional Chinese medicinal materials, and can decompose protease. Has repairing effect on necrotic tissue, blood vessel, and nervous system; contains linoleic acid, linolenic acid, vitamin E, lecithin, etc. which have good repairing effect on body cells and also have the functions of moistening, relieving pain and activating blood.

By combining a pharmacological mechanism and a preparation scheme, the special effects of the invention are as follows:

1. the Chinese medicinal materials including coptis root, angelica, forsythia and the like have the functions of clearing heat and removing toxicity, benefiting five internal organs, promoting metabolism, treating diabetes, dissolving lumps, removing blood stasis and growing muscles, so that the healing of wound surfaces is accelerated;

2. eliminating wound pain in a non-anesthesia mode: in the traditional Chinese medicinal materials, the Chinese angelica, the lithospermum, the beeswax, the sesame oil and other medicines have the effects of relaxing muscles and tendons, promoting blood circulation, dilating blood vessels, diminishing inflammation, easing pain, improving microcirculation and promoting the repair of a nervous system. After the ointment is applied to a wound surface, natural active ingredients of the ointment quickly act on the wound surface, a patient immediately has a cool and moist feeling, the pain of the wound surface is quickly relieved, the increase of active factors around the wound surface and the revival of residual cells are promoted, and fresh granulation grows out;

3. the whole function of the medicine is played: in the medicinal materials, the plants and the animals form an organic proportion, and the process manufacturing processes interact with each other, so that the whole function can be presented. For example, the wound healing agent has super-strong anti-infection property, inhibits the growth of bacteria (particularly the reproduction of anaerobic bacteria), activates the growth of residual cells of the wound and cells around necrotic organisms, accelerates the blood circulation, promotes the sprouting of granulation and the recovery of functions of five internal organs, and accelerates the regeneration and the recurrence of hair follicle nerves, thereby accelerating the healing process of the wound;

the preparation scheme of the invention is simple, the quality index is easy to control, the use is convenient, safe and effective, and the characteristic components of the medicine can be extracted to a great extent, so that the curative effect of the medicine is improved.

The specific implementation mode is as follows:

the following detailed description of the embodiments of the invention is intended to be illustrative, and not to be construed as limiting the invention.

The traditional Chinese medicine ointment preparation for treating diabetic foot is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4-5 parts (preferably 3 parts) of lithospermum, 2-3 parts (preferably 2.5 parts) of raw gardenia kernel, 1-1.5 parts (preferably 1.3 parts) of coptis chinensis, 2-3 parts (preferably 2.5 parts) of fructus forsythiae, 2-3 parts (preferably 2.5 parts) of angelica sinensis, 7-9 parts (preferably 8 parts) of beeswax and 74-82 parts (preferably 78 or 80 parts) of sesame oil. In particular, each serving may be 100 grams or 300 grams or 500 grams.

Preferably, the traditional Chinese medicine ointment preparation for treating diabetic foot is prepared from the following traditional Chinese medicine raw materials in parts by weight: 400 g of lithospermum, 200 g of raw gardenia kernel, 100 g of coptis root, 200 g of forsythia, 200 g of angelica, 700 g of beeswax and 8000 g of sesame oil.

The traditional Chinese medicine ointment preparation for treating diabetic foot is characterized by being prepared from the following traditional Chinese medicine raw materials: 4-5 parts of lithospermum, 2-3 parts of raw gardenia kernel, 1-1.5 parts of coptis chinensis, 2-3 parts of fructus forsythiae, 2-3 parts of angelica sinensis, 7-9 parts of beeswax and 74-82 parts of sesame oil. Specifically, each serving may be 100 grams.

The preparation method of the traditional Chinese medicine ointment preparation for treating diabetic foot comprises the following steps:

the method comprises the following steps: removing dust from radix Arnebiae, fructus Gardeniae, Coptidis rhizoma, fructus forsythiae and radix Angelicae sinensis;

step two: pulverizing radix Arnebiae, and cutting radix Angelicae sinensis into pieces;

step three: placing radix Arnebiae, fructus Gardeniae, Coptidis rhizoma, fructus forsythiae, and radix Angelicae sinensis into a container, adding oleum Sesami, and soaking for 120 hr to obtain an oil-medicine mixture;

step four: soaking oleum Sesami in the mixture of the above materials, decocting for 25-30 min, stopping heating for 15 min, decocting for 30-35 min, stopping heating for 15 min, and decocting for 20 min;

step five: filtering the oil-medicine mixture obtained in the step four by using sterile gauze, and squeezing by using a squeezer to obtain a liquid medicine;

step six: pouring the liquid medicine into a container, heating to a boiling point, adding the cut beeswax, and uniformly stirring until the beeswax is completely dissolved to obtain a medicament;

step seven: cooling the medicinal preparation to obtain unguent;

step eight: packaging and storing the ointment.

The seven Chinese medicinal materials are prepared into the externally applied traditional Chinese medicine ointment preparation according to the weight proportion. The traditional Chinese medicine ointment preparation for treating diabetic foot and the preparation method thereof according to the claim. The following complete treatments are required:

(1) the primary disease is strictly controlled. When the blood pressure of a patient rises, glycated protein does not reach the standard, main arterial blood vessels are not smooth and fever occurs, local blood circulation disorder can be increased, and wound healing is seriously affected. In order to accelerate the improvement and improvement of the state of an illness, the regulation is carried out through a 'six-frame carriage' for conditioning diabetes, sufficient systematic scientific management is carried out in the whole process, the blood sugar is stabilized in a proper range, and the body temperature is controlled to be about 37 ℃. If the aorta of the lower limb of the patient is in pulsation descent or basically loses blood circulation, the patient needs to be subjected to intervention or upper bracket operation in time, so that the normal blood and oxygen supply is basically realized.

(2) Local treatment and differential treatment. Different treatments were taken for positive and negative ulcers. Positive ulcer with fever, local red swelling and hot pain. Antibiotics are used appropriately to combat infection. Negative ulcer is only needed to be coated on the wound surface by adopting the ointment preparation of the invention.

(3) Treat the disease according to the syndrome differentiation and treat the disease as appropriate. The diabetic foot condition can be classified into one to five grades according to modern medicine: the first level is small-area sores and ulcers, and the infection is not severe; the second level is serious infection, large sore area and deep cave; the third level is large area of sores and ulcers, serious infection, deep holes or honeycombed state of feet with foul odor; the fourth level is that the wound surface basically relates to most of feet, the lower limbs are black, the infection is serious, bones can be seen in caves, and most of the wounds are necrotic; the fifth grade is the complete foot gangrene, necrosis of part of the bones and the basically black whole calf. The graded treatment was as follows: 1. the external application medicine can be directly applied to the first-class diabetic foot once a day, and the diabetic foot can be cured in about one week; 2. the secondary and tertiary treatment methods for diabetic feet are as follows: in the early stage, antibiotics is adopted to resist infection, the lower limb aorta is obstructed, intervention or upper bracket treatment is carried out by adopting the cooperation of Chinese and western technologies, the artery and blood vessels are dredged, the ointment preparation is coated and arranged on sterile gauze, and the ointment is applied twice every day; if the cave of the patient is deep, the wound surface is filled with the ointment and the gauze; if the foot is in a honeycomb state, the ointment gauze is slowly drained to the hole in the wound to fill the wound, the medicine is applied twice a day, the condition of the patient is basically improved, when fresh granulation is seen, the antibiotic is stopped, and the medicine is applied once a day; 3. for diabetic foot in the fourth stage, a very careful and careful treatment management protocol is adopted: firstly, blood sugar is controlled and stabilized, and secondly, intervention or upper bracket operation is carried out immediately when blood vessels of lower limbs are obstructed, so that nutrient liquid medicine is supplemented in time, and the physique of the patient is improved. Thirdly, the antibiotic is used for diminishing inflammation and resisting bacteria, the traditional Chinese medicine preparation for relaxing tendons and activating blood circulation, and removing necrotic tissue and promoting granulation is orally taken, the lower limbs are frequently wiped by a warm towel, the ointment preparation is applied for 2-3 times every day, and generally the lower limbs can be cured in about three months.

The typical medical record cured by the invention is as follows.

Case one:

the patient, HuXX, female, aged 89, was carelessly scalded by boiled water in 23 pm in 12 months in 2017, and was sent to a Hospital hospital in my market the next day for hospitalization. The patient is examined by a hospital to be II type diabetes, mild anemia and deep II degree scald. Eight days of hospitalization, the condition of the disease is continuously worsened, the wound surface is enlarged, the infection is serious, the deep cave is formed, the ankle bones are seen, and the high fever is not relieved. The hospital consultation conclusion is as follows: amputation is performed immediately, otherwise life-threatening. And then transferred to the research institute for treatment. The examination is as follows: type II diabetes, with a history of more than ten years, with diabetes on the fourth level; mild anemia; dry and numb skin of lower limbs; aortic beat attenuation; sensation, touch, warmth, decline; the left instep is black, the ankle joint has a 7.5X 4cm ulcer cave, the ankle joint bone is exposed, and has many essential substances and bad odor. The treatment process comprises the following steps: the antibiotic antiphlogistic and antibacterial ointment is used for diminishing inflammation and resisting bacteria, supplementing nutrient liquid medicine and food, injecting insulin and orally taking traditional Chinese medicine medicaments for reducing blood pressure and blood sugar, relaxing tendons and activating collaterals, externally applying the ointment preparation to fill and level the wound surface, applying the ointment twice a day, and healing and recovering after 63 days of elaborate treatment.

Case two:

according to the traditional Chinese medicine, old xx, male, the age of 53, and both feet are carelessly scalded by boiled water in the middle 8 th of 2018, and when a certain three-part hospital in the liberation army is hospitalized for thirteen days in the local market, the disease condition is continuously worsened, the wound surface is infected with ulcer, particularly the right foot is more serious, the lower limbs are swollen, the back of the foot is in a honeycomb state, partial necrosis is caused, and high fever is not reduced. The consultation conclusion of the hospital is as follows: amputation should be performed immediately, otherwise the consequences are inconceivable. Later, the patient carried the trial to the study department for treatment. Through the examination: type I diabetes, 13 years of history, three-level diabetic foot, high blood pressure and diabetic complication nephropathy; dry mouth and tongue, edema, numbness and pain of both lower limbs; aortic pulsation declination, double-foot ulcer, honeycomb right foot part gangrene and obvious odor. The treatment process comprises the following steps: the blood pressure and blood sugar indexes are stabilized by antibiotic anti-infection and oral administration of blood pressure and blood sugar lowering drugs; the ointment preparation is externally applied and drained twice every day, and recovery is realized after 30 days of heart-essence treatment.

Case three:

yang xx, female, 73 years old, and in the middle of 2018 Yuan, the patients have different degrees of blisters on both feet, and the patients enter the research institute for treatment, and through examination, type I diabetes mellitus, the disease history of eleven years, the secondary grade of diabetes mellitus, anemia, nephropathy, sensation of consciousness, touch, temperature sensation and decline are complicated; dry lower limbs, skin itching; aortic pulsation is reduced; the feet had 7 blisters, the right foot was more severe. The treatment process comprises the following steps: cooperating with a third technology in this market, a hospital carries out interventional operation on a patient to dredge the aorta vessel; after operation, the inventor researches the used antibiotics to resist infection and orally take hypoglycemic drugs to stabilize blood sugar; the ointment of the invention is externally applied for 2 times every day, and the recovery is achieved after the careful treatment for 62 days.

Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention, and that variations, modifications, substitutions and alterations can be made in the above embodiments by those of ordinary skill in the art without departing from the principle and spirit of the present invention.

Claims (2)

1. A traditional Chinese medicine ointment preparation for treating diabetic foot is characterized by comprising the following components in parts by weight: 3 parts of lithospermum; 2.5 parts of raw gardenia kernels; 1.3 parts of coptis chinensis; 2.5 parts of fructus forsythiae; 2.5 parts of angelica; 8 parts of beeswax; 78 parts or 80 parts of sesame oil.

2. A method for preparing the traditional Chinese medicine ointment preparation for treating diabetic foot according to claim 1, which is characterized by comprising the following steps:

the method comprises the following steps: removing dust from radix Arnebiae, fructus Gardeniae, Coptidis rhizoma, fructus forsythiae and radix Angelicae sinensis;

step two: pulverizing radix Arnebiae, and cutting radix Angelicae sinensis into pieces;

step three: placing radix Arnebiae, fructus Gardeniae, Coptidis rhizoma, fructus forsythiae, and radix Angelicae sinensis into a container, adding oleum Sesami, and soaking for 120 hr to obtain an oil-medicine mixture;

step four: soaking oleum Sesami in the mixture of the above materials, decocting for 25-30 min, stopping heating for 15 min, decocting for 30-35 min, stopping heating for 15 min, and decocting for 20 min;

step five; filtering the oil-medicine mixture obtained in the step four by using sterile gauze, and squeezing by using a squeezer to obtain a liquid medicine;

step six: pouring the liquid medicine into a container, heating to a boiling point, adding the cut beeswax, and uniformly stirring until the beeswax is completely dissolved to obtain a medicament;

step seven: cooling the medicinal preparation to obtain unguent;

step eight: and packaging and storing the ointment.