CN112076305A - A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation - Google Patents
A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation Download PDFInfo
- Publication number
- CN112076305A CN112076305A CN201910528945.3A CN201910528945A CN112076305A CN 112076305 A CN112076305 A CN 112076305A CN 201910528945 A CN201910528945 A CN 201910528945A CN 112076305 A CN112076305 A CN 112076305A
- Authority
- CN
- China
- Prior art keywords
- dried
- inflammation
- treating
- oral
- stock solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 49
- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 46
- 239000011550 stock solution Substances 0.000 title claims abstract description 42
- 208000001145 Metabolic Syndrome Diseases 0.000 title claims abstract description 39
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 title claims abstract description 38
- 241000894006 Bacteria Species 0.000 title claims description 26
- 230000000699 topical effect Effects 0.000 title claims description 12
- 230000000694 effects Effects 0.000 claims abstract description 72
- 239000003814 drug Substances 0.000 claims abstract description 43
- 244000269722 Thea sinensis Species 0.000 claims abstract description 40
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- 230000001954 sterilising effect Effects 0.000 claims abstract description 30
- 238000000034 method Methods 0.000 claims abstract description 27
- 230000003467 diminishing effect Effects 0.000 claims abstract description 26
- 241001264174 Cordyceps militaris Species 0.000 claims abstract description 25
- 235000013616 tea Nutrition 0.000 claims abstract description 23
- 241001474374 Blennius Species 0.000 claims abstract description 20
- 208000024891 symptom Diseases 0.000 claims abstract description 20
- 240000000249 Morus alba Species 0.000 claims abstract description 19
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 19
- 235000009569 green tea Nutrition 0.000 claims abstract description 18
- 235000003261 Artemisia vulgaris Nutrition 0.000 claims abstract description 17
- 244000276331 Citrus maxima Species 0.000 claims abstract description 17
- 235000001759 Citrus maxima Nutrition 0.000 claims abstract description 17
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 17
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 17
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 17
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 claims abstract description 16
- 235000003097 Artemisia absinthium Nutrition 0.000 claims abstract description 16
- 240000001851 Artemisia dracunculus Species 0.000 claims abstract description 16
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 claims abstract description 16
- 239000001138 artemisia absinthium Substances 0.000 claims abstract description 16
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract description 16
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 16
- 235000011477 liquorice Nutrition 0.000 claims abstract description 16
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims abstract description 16
- 235000009467 Carica papaya Nutrition 0.000 claims abstract description 15
- 241000233866 Fungi Species 0.000 claims abstract description 15
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 15
- 235000006533 astragalus Nutrition 0.000 claims abstract description 15
- 235000008397 ginger Nutrition 0.000 claims abstract description 15
- 235000009917 Crataegus X brevipes Nutrition 0.000 claims abstract description 14
- 235000013204 Crataegus X haemacarpa Nutrition 0.000 claims abstract description 14
- 235000009685 Crataegus X maligna Nutrition 0.000 claims abstract description 14
- 235000009444 Crataegus X rubrocarnea Nutrition 0.000 claims abstract description 14
- 235000009486 Crataegus bullatus Nutrition 0.000 claims abstract description 14
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 claims abstract description 14
- 235000009682 Crataegus limnophila Nutrition 0.000 claims abstract description 14
- 235000004423 Crataegus monogyna Nutrition 0.000 claims abstract description 14
- 235000002313 Crataegus paludosa Nutrition 0.000 claims abstract description 14
- 235000009840 Crataegus x incaedua Nutrition 0.000 claims abstract description 14
- 241001523681 Dendrobium Species 0.000 claims abstract description 14
- 241001244920 Eucomis bicolor Species 0.000 claims abstract description 14
- 241001018563 Nekemias grossedentata Species 0.000 claims abstract description 14
- 235000006264 Asimina triloba Nutrition 0.000 claims abstract description 13
- 241001061264 Astragalus Species 0.000 claims abstract description 12
- 206010010774 Constipation Diseases 0.000 claims abstract description 12
- 206010020772 Hypertension Diseases 0.000 claims abstract description 12
- 208000003251 Pruritus Diseases 0.000 claims abstract description 12
- 238000004821 distillation Methods 0.000 claims abstract description 12
- 210000004233 talus Anatomy 0.000 claims abstract description 12
- 208000008589 Obesity Diseases 0.000 claims abstract description 11
- 206010030113 Oedema Diseases 0.000 claims abstract description 11
- 235000020824 obesity Nutrition 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 11
- 230000006378 damage Effects 0.000 claims abstract description 10
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 9
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 9
- 206010000496 acne Diseases 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 9
- 206010006326 Breath odour Diseases 0.000 claims abstract description 8
- 208000032139 Halitosis Diseases 0.000 claims abstract description 8
- 208000031226 Hyperlipidaemia Diseases 0.000 claims abstract description 8
- 206010052428 Wound Diseases 0.000 claims abstract description 8
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims abstract description 7
- 208000025865 Ulcer Diseases 0.000 claims abstract description 7
- 210000002683 foot Anatomy 0.000 claims abstract description 7
- 206010022437 insomnia Diseases 0.000 claims abstract description 7
- 230000007803 itching Effects 0.000 claims abstract description 7
- 231100000397 ulcer Toxicity 0.000 claims abstract description 7
- 208000035985 Body Odor Diseases 0.000 claims abstract description 6
- 208000007882 Gastritis Diseases 0.000 claims abstract description 6
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 6
- 208000012886 Vertigo Diseases 0.000 claims abstract description 6
- 208000014617 hemorrhoid Diseases 0.000 claims abstract description 6
- 201000001421 hyperglycemia Diseases 0.000 claims abstract description 6
- 231100000889 vertigo Toxicity 0.000 claims abstract description 6
- 201000004384 Alopecia Diseases 0.000 claims abstract description 5
- 206010055000 Bromhidrosis Diseases 0.000 claims abstract description 5
- 201000005569 Gout Diseases 0.000 claims abstract description 5
- 208000004044 Hypesthesia Diseases 0.000 claims abstract description 5
- 208000010195 Onychomycosis Diseases 0.000 claims abstract description 5
- 208000007117 Oral Ulcer Diseases 0.000 claims abstract description 5
- 206010034016 Paronychia Diseases 0.000 claims abstract description 5
- 241000029132 Paronychia Species 0.000 claims abstract description 5
- 231100000360 alopecia Toxicity 0.000 claims abstract description 5
- 208000002399 aphthous stomatitis Diseases 0.000 claims abstract description 5
- 208000034783 hypoesthesia Diseases 0.000 claims abstract description 5
- 201000009240 nasopharyngitis Diseases 0.000 claims abstract description 5
- 231100000862 numbness Toxicity 0.000 claims abstract description 5
- 201000004647 tinea pedis Diseases 0.000 claims abstract description 5
- 201000005882 tinea unguium Diseases 0.000 claims abstract description 5
- 208000004371 toothache Diseases 0.000 claims abstract description 5
- 244000189799 Asimina triloba Species 0.000 claims abstract 3
- 240000000171 Crataegus monogyna Species 0.000 claims abstract 3
- 244000273928 Zingiber officinale Species 0.000 claims abstract 3
- 206010062717 Increased upper airway secretion Diseases 0.000 claims description 28
- 208000026435 phlegm Diseases 0.000 claims description 28
- 238000009835 boiling Methods 0.000 claims description 23
- 210000002784 stomach Anatomy 0.000 claims description 22
- 230000006870 function Effects 0.000 claims description 14
- 230000008961 swelling Effects 0.000 claims description 14
- 230000004060 metabolic process Effects 0.000 claims description 13
- 238000004659 sterilization and disinfection Methods 0.000 claims description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 10
- 230000000844 anti-bacterial effect Effects 0.000 claims description 8
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 8
- 238000011049 filling Methods 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- 239000012467 final product Substances 0.000 claims description 7
- 238000001256 steam distillation Methods 0.000 claims description 7
- 208000035475 disorder Diseases 0.000 claims description 5
- 208000011580 syndromic disease Diseases 0.000 claims description 5
- 231100000331 toxic Toxicity 0.000 claims description 5
- 230000002588 toxic effect Effects 0.000 claims description 5
- 230000001139 anti-pruritic effect Effects 0.000 claims description 4
- 239000003908 antipruritic agent Substances 0.000 claims description 4
- 239000000843 powder Substances 0.000 claims description 4
- 238000007873 sieving Methods 0.000 claims description 4
- 241000045403 Astragalus propinquus Species 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 abstract description 6
- 238000001914 filtration Methods 0.000 abstract description 4
- 230000015572 biosynthetic process Effects 0.000 abstract description 3
- 238000003786 synthesis reaction Methods 0.000 abstract description 2
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 description 43
- 239000008280 blood Substances 0.000 description 43
- 210000000952 spleen Anatomy 0.000 description 30
- 239000003925 fat Substances 0.000 description 28
- 235000019197 fats Nutrition 0.000 description 25
- 210000003491 skin Anatomy 0.000 description 24
- 230000001737 promoting effect Effects 0.000 description 23
- 210000004072 lung Anatomy 0.000 description 22
- 210000003734 kidney Anatomy 0.000 description 21
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 16
- 206010011224 Cough Diseases 0.000 description 15
- 208000007536 Thrombosis Diseases 0.000 description 15
- 230000037303 wrinkles Effects 0.000 description 14
- 230000007812 deficiency Effects 0.000 description 13
- 235000018102 proteins Nutrition 0.000 description 13
- 102000004169 proteins and genes Human genes 0.000 description 13
- 108090000623 proteins and genes Proteins 0.000 description 13
- 240000006432 Carica papaya Species 0.000 description 12
- 241001092040 Crataegus Species 0.000 description 12
- 241000234314 Zingiber Species 0.000 description 12
- 230000029087 digestion Effects 0.000 description 12
- 210000004185 liver Anatomy 0.000 description 12
- 229940024606 amino acid Drugs 0.000 description 11
- 235000001014 amino acid Nutrition 0.000 description 11
- 150000001413 amino acids Chemical class 0.000 description 11
- 210000004204 blood vessel Anatomy 0.000 description 11
- 229940088594 vitamin Drugs 0.000 description 11
- 229930003231 vitamin Natural products 0.000 description 11
- 235000013343 vitamin Nutrition 0.000 description 11
- 239000011782 vitamin Substances 0.000 description 11
- 208000002193 Pain Diseases 0.000 description 10
- 230000036772 blood pressure Effects 0.000 description 10
- 230000036407 pain Effects 0.000 description 10
- 241000675108 Citrus tangerina Species 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 9
- 235000009508 confectionery Nutrition 0.000 description 9
- 230000002401 inhibitory effect Effects 0.000 description 9
- 239000003053 toxin Substances 0.000 description 9
- 231100000765 toxin Toxicity 0.000 description 9
- 108700012359 toxins Proteins 0.000 description 9
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 8
- 239000004365 Protease Substances 0.000 description 8
- 235000014113 dietary fatty acids Nutrition 0.000 description 8
- 239000000194 fatty acid Substances 0.000 description 8
- 229930195729 fatty acid Natural products 0.000 description 8
- 150000004665 fatty acids Chemical class 0.000 description 8
- 210000000936 intestine Anatomy 0.000 description 8
- 210000003205 muscle Anatomy 0.000 description 8
- 206010012735 Diarrhoea Diseases 0.000 description 7
- 102000004190 Enzymes Human genes 0.000 description 7
- 108090000790 Enzymes Proteins 0.000 description 7
- 238000009825 accumulation Methods 0.000 description 7
- 150000001720 carbohydrates Chemical class 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 229940088598 enzyme Drugs 0.000 description 7
- 230000004438 eyesight Effects 0.000 description 7
- 210000002216 heart Anatomy 0.000 description 7
- 230000036039 immunity Effects 0.000 description 7
- 150000004804 polysaccharides Chemical class 0.000 description 7
- 206010000060 Abdominal distension Diseases 0.000 description 6
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 6
- 208000005392 Spasm Diseases 0.000 description 6
- 201000006549 dyspepsia Diseases 0.000 description 6
- 206010016256 fatigue Diseases 0.000 description 6
- 229930003935 flavonoid Natural products 0.000 description 6
- 150000002215 flavonoids Chemical class 0.000 description 6
- 235000017173 flavonoids Nutrition 0.000 description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 description 6
- 239000008103 glucose Substances 0.000 description 6
- 230000001965 increasing effect Effects 0.000 description 6
- 230000002147 killing effect Effects 0.000 description 6
- 150000002632 lipids Chemical class 0.000 description 6
- 229920001282 polysaccharide Polymers 0.000 description 6
- 239000005017 polysaccharide Substances 0.000 description 6
- 238000005728 strengthening Methods 0.000 description 6
- 208000008035 Back Pain Diseases 0.000 description 5
- 206010008479 Chest Pain Diseases 0.000 description 5
- 102000000588 Interleukin-2 Human genes 0.000 description 5
- 108010002350 Interleukin-2 Proteins 0.000 description 5
- 241000699666 Mus <mouse, genus> Species 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 5
- 206010003549 asthenia Diseases 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 5
- 235000012000 cholesterol Nutrition 0.000 description 5
- RYAHJFGVOCZDEI-CZKZLRAZSA-N dendrobine Natural products O=C1O[C@@H]2[C@H](C(C)C)[C@H]1[C@H]1[C@@]3(C)[C@@H]2N(C)C[C@H]3CC1 RYAHJFGVOCZDEI-CZKZLRAZSA-N 0.000 description 5
- 208000002173 dizziness Diseases 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 5
- 235000019634 flavors Nutrition 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 235000019645 odor Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 239000003440 toxic substance Substances 0.000 description 5
- 235000019154 vitamin C Nutrition 0.000 description 5
- 239000011718 vitamin C Substances 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 4
- 108010035532 Collagen Proteins 0.000 description 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 4
- RYAHJFGVOCZDEI-UFFNCVEVSA-N Dendrobine Chemical compound C([C@H]1CC[C@@H]2[C@@]31C)N(C)[C@@H]3[C@H]1[C@@H](C(C)C)[C@@H]2C(=O)O1 RYAHJFGVOCZDEI-UFFNCVEVSA-N 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 4
- 208000013016 Hypoglycemia Diseases 0.000 description 4
- 102000008070 Interferon-gamma Human genes 0.000 description 4
- 108010074328 Interferon-gamma Proteins 0.000 description 4
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 208000004880 Polyuria Diseases 0.000 description 4
- 206010054094 Tumour necrosis Diseases 0.000 description 4
- 229930003268 Vitamin C Natural products 0.000 description 4
- 208000022531 anorexia Diseases 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 235000014633 carbohydrates Nutrition 0.000 description 4
- 235000005473 carotenes Nutrition 0.000 description 4
- 150000001746 carotenes Chemical class 0.000 description 4
- 229920001436 collagen Polymers 0.000 description 4
- 206010061428 decreased appetite Diseases 0.000 description 4
- 239000000835 fiber Substances 0.000 description 4
- 229940044627 gamma-interferon Drugs 0.000 description 4
- 230000002218 hypoglycaemic effect Effects 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 230000000968 intestinal effect Effects 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 235000016709 nutrition Nutrition 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 description 4
- 235000013824 polyphenols Nutrition 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 239000013589 supplement Substances 0.000 description 4
- 210000002435 tendon Anatomy 0.000 description 4
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 4
- -1 7-glucoside Natural products 0.000 description 3
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 206010003210 Arteriosclerosis Diseases 0.000 description 3
- 229920002527 Glycogen Polymers 0.000 description 3
- 208000008930 Low Back Pain Diseases 0.000 description 3
- 206010028813 Nausea Diseases 0.000 description 3
- 206010033557 Palpitations Diseases 0.000 description 3
- 108090000526 Papain Proteins 0.000 description 3
- 108091005804 Peptidases Proteins 0.000 description 3
- 241000588769 Proteus <enterobacteria> Species 0.000 description 3
- 241000607142 Salmonella Species 0.000 description 3
- 241000607132 Salmonella enterica subsp. enterica serovar Gallinarum Species 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 206010047700 Vomiting Diseases 0.000 description 3
- 210000001015 abdomen Anatomy 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 239000000783 alginic acid Substances 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 229960001126 alginic acid Drugs 0.000 description 3
- 150000004781 alginic acids Chemical class 0.000 description 3
- 208000011775 arteriosclerosis disease Diseases 0.000 description 3
- 208000026106 cerebrovascular disease Diseases 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000003745 diagnosis Methods 0.000 description 3
- 235000013325 dietary fiber Nutrition 0.000 description 3
- 230000001079 digestive effect Effects 0.000 description 3
- 102000038379 digestive enzymes Human genes 0.000 description 3
- 108091007734 digestive enzymes Proteins 0.000 description 3
- 230000035619 diuresis Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 208000001848 dysentery Diseases 0.000 description 3
- 230000004064 dysfunction Effects 0.000 description 3
- 230000002526 effect on cardiovascular system Effects 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 210000003414 extremity Anatomy 0.000 description 3
- 210000000744 eyelid Anatomy 0.000 description 3
- 229930003944 flavone Natural products 0.000 description 3
- 150000002212 flavone derivatives Chemical class 0.000 description 3
- 235000011949 flavones Nutrition 0.000 description 3
- 229940096919 glycogen Drugs 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 208000030159 metabolic disease Diseases 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 230000008693 nausea Effects 0.000 description 3
- 231100000252 nontoxic Toxicity 0.000 description 3
- 230000003000 nontoxic effect Effects 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 235000019834 papain Nutrition 0.000 description 3
- 229940055729 papain Drugs 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 230000002936 tranquilizing effect Effects 0.000 description 3
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 3
- 239000000341 volatile oil Substances 0.000 description 3
- KJXSIXMJHKAJOD-LSDHHAIUSA-N (+)-dihydromyricetin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC(O)=C(O)C(O)=C1 KJXSIXMJHKAJOD-LSDHHAIUSA-N 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- 206010000077 Abdominal mass Diseases 0.000 description 2
- 102000013142 Amylases Human genes 0.000 description 2
- 108010065511 Amylases Proteins 0.000 description 2
- 244000099147 Ananas comosus Species 0.000 description 2
- 235000007119 Ananas comosus Nutrition 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 2
- 241000221377 Auricularia Species 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 2
- 108010004032 Bromelains Proteins 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- 206010007247 Carbuncle Diseases 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- 206010008132 Cerebral thrombosis Diseases 0.000 description 2
- 240000004638 Dendrobium nobile Species 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000001263 FEMA 3042 Substances 0.000 description 2
- 206010016807 Fluid retention Diseases 0.000 description 2
- 108010023302 HDL Cholesterol Proteins 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 108090001060 Lipase Proteins 0.000 description 2
- 239000004367 Lipase Substances 0.000 description 2
- 102000004882 Lipase Human genes 0.000 description 2
- 206010024642 Listless Diseases 0.000 description 2
- 208000007101 Muscle Cramp Diseases 0.000 description 2
- DATAGRPVKZEWHA-YFKPBYRVSA-N N(5)-ethyl-L-glutamine Chemical compound CCNC(=O)CC[C@H]([NH3+])C([O-])=O DATAGRPVKZEWHA-YFKPBYRVSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 2
- 201000007100 Pharyngitis Diseases 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 2
- 206010040007 Sense of oppression Diseases 0.000 description 2
- 206010041349 Somnolence Diseases 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 2
- 241000194017 Streptococcus Species 0.000 description 2
- 102000003929 Transaminases Human genes 0.000 description 2
- 108090000340 Transaminases Proteins 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 229930003451 Vitamin B1 Natural products 0.000 description 2
- 208000019790 abdominal distention Diseases 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000009102 absorption Effects 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 235000019418 amylase Nutrition 0.000 description 2
- 239000002260 anti-inflammatory agent Substances 0.000 description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 description 2
- 239000003146 anticoagulant agent Substances 0.000 description 2
- 229940127219 anticoagulant drug Drugs 0.000 description 2
- 229940107666 astragalus root Drugs 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 230000036770 blood supply Effects 0.000 description 2
- 210000001124 body fluid Anatomy 0.000 description 2
- 239000010839 body fluid Substances 0.000 description 2
- 235000019835 bromelain Nutrition 0.000 description 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- ZZAJQOPSWWVMBI-UHFFFAOYSA-N calycosin Chemical compound C1=C(O)C(OC)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZZAJQOPSWWVMBI-UHFFFAOYSA-N 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000008021 deposition Effects 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 206010013990 dysuria Diseases 0.000 description 2
- 235000019441 ethanol Nutrition 0.000 description 2
- 230000001815 facial effect Effects 0.000 description 2
- 201000005577 familial hyperlipidemia Diseases 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 2
- 235000002780 gingerol Nutrition 0.000 description 2
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- 230000002439 hemostatic effect Effects 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 235000003642 hunger Nutrition 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 239000000787 lecithin Substances 0.000 description 2
- 235000010445 lecithin Nutrition 0.000 description 2
- 229940067606 lecithin Drugs 0.000 description 2
- 235000019421 lipase Nutrition 0.000 description 2
- 208000017971 listlessness Diseases 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 210000005036 nerve Anatomy 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 235000005985 organic acids Nutrition 0.000 description 2
- 210000000496 pancreas Anatomy 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 150000002989 phenols Chemical class 0.000 description 2
- 235000007686 potassium Nutrition 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 235000019419 proteases Nutrition 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 229930182490 saponin Natural products 0.000 description 2
- 150000007949 saponins Chemical class 0.000 description 2
- 230000007958 sleep Effects 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 150000003432 sterols Chemical class 0.000 description 2
- 235000003702 sterols Nutrition 0.000 description 2
- 235000015523 tannic acid Nutrition 0.000 description 2
- 229920002258 tannic acid Polymers 0.000 description 2
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 2
- 229940033123 tannic acid Drugs 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 231100000167 toxic agent Toxicity 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 210000001835 viscera Anatomy 0.000 description 2
- 235000019155 vitamin A Nutrition 0.000 description 2
- 239000011719 vitamin A Substances 0.000 description 2
- 235000010374 vitamin B1 Nutrition 0.000 description 2
- 239000011691 vitamin B1 Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- 230000002087 whitening effect Effects 0.000 description 2
- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- OQWKEEOHDMUXEO-UHFFFAOYSA-N (6)-shogaol Natural products CCCCCC=CC(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- USMNOWBWPHYOEA-UHFFFAOYSA-N 3‐isothujone Chemical compound CC1C(=O)CC2(C(C)C)C1C2 USMNOWBWPHYOEA-UHFFFAOYSA-N 0.000 description 1
- HOMSOWZTBJWNHP-UHFFFAOYSA-N 5-chlorothiadiazole Chemical compound ClC1=CN=NS1 HOMSOWZTBJWNHP-UHFFFAOYSA-N 0.000 description 1
- QSNCUGULHPBRGR-FYPZSMAZSA-N 6-Hydroxydendrobine Natural products O=C1O[C@@H]2[C@@H](C(C)C)[C@H]1[C@@]1(O)[C@@]3(C)[C@@H]2N(C)C[C@H]3CC1 QSNCUGULHPBRGR-FYPZSMAZSA-N 0.000 description 1
- 239000001606 7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)chroman-4-one Substances 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010001580 Albuminuria Diseases 0.000 description 1
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 1
- 208000000044 Amnesia Diseases 0.000 description 1
- 208000031091 Amnestic disease Diseases 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 206010002482 Angiosclerosis Diseases 0.000 description 1
- 240000006891 Artemisia vulgaris Species 0.000 description 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 206010005746 Blood pressure fluctuation Diseases 0.000 description 1
- 206010006895 Cachexia Diseases 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 206010008111 Cerebral haemorrhage Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 description 1
- 241000190633 Cordyceps Species 0.000 description 1
- 235000014493 Crataegus Nutrition 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- IVOMOUWHDPKRLL-KQYNXXCUSA-N Cyclic adenosine monophosphate Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=CN=C2N)=C2N=C1 IVOMOUWHDPKRLL-KQYNXXCUSA-N 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- NBSCHQHZLSJFNQ-GASJEMHNSA-N D-Glucose 6-phosphate Chemical compound OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O NBSCHQHZLSJFNQ-GASJEMHNSA-N 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 206010011878 Deafness Diseases 0.000 description 1
- 206010051055 Deep vein thrombosis Diseases 0.000 description 1
- 208000001380 Diabetic Ketoacidosis Diseases 0.000 description 1
- 206010012669 Diabetic hyperosmolar coma Diseases 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- 208000030453 Drug-Related Side Effects and Adverse reaction Diseases 0.000 description 1
- 208000032928 Dyslipidaemia Diseases 0.000 description 1
- 206010014970 Ephelides Diseases 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 206010016029 Face oedema Diseases 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 102000008946 Fibrinogen Human genes 0.000 description 1
- 108010049003 Fibrinogen Proteins 0.000 description 1
- 108010088842 Fibrinolysin Proteins 0.000 description 1
- VFRROHXSMXFLSN-UHFFFAOYSA-N Glc6P Natural products OP(=O)(O)OCC(O)C(O)C(O)C(O)C=O VFRROHXSMXFLSN-UHFFFAOYSA-N 0.000 description 1
- 206010018367 Glomerulonephritis chronic Diseases 0.000 description 1
- 108010001483 Glycogen Synthase Proteins 0.000 description 1
- MPDGHEJMBKOTSU-UHFFFAOYSA-N Glycyrrhetinsaeure Natural products C12C(=O)C=C3C4CC(C)(C(O)=O)CCC4(C)CCC3(C)C1(C)CCC1C2(C)CCC(O)C1(C)C MPDGHEJMBKOTSU-UHFFFAOYSA-N 0.000 description 1
- 241000202807 Glycyrrhiza Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 206010018910 Haemolysis Diseases 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- 235000018142 Hedysarum alpinum var americanum Nutrition 0.000 description 1
- 240000006461 Hedysarum alpinum var. americanum Species 0.000 description 1
- 208000000857 Hepatic Insufficiency Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- QUQPHWDTPGMPEX-UHFFFAOYSA-N Hesperidine Natural products C1=C(O)C(OC)=CC=C1C1OC2=CC(OC3C(C(O)C(O)C(COC4C(C(O)C(O)C(C)O4)O)O3)O)=CC(O)=C2C(=O)C1 QUQPHWDTPGMPEX-UHFFFAOYSA-N 0.000 description 1
- 206010020601 Hyperchlorhydria Diseases 0.000 description 1
- OVSQVDMCBVZWGM-SJWGPRHPSA-N Hyperin Natural products O[C@H]1[C@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-SJWGPRHPSA-N 0.000 description 1
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 1
- 206010023379 Ketoacidosis Diseases 0.000 description 1
- 208000007976 Ketosis Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 108010028554 LDL Cholesterol Proteins 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 229930194248 Licoflavone Natural products 0.000 description 1
- MEHHCBRCXIDGKZ-UHFFFAOYSA-N Licoflavone C Natural products CC(C)=CCC1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 MEHHCBRCXIDGKZ-UHFFFAOYSA-N 0.000 description 1
- 206010024604 Lipoatrophy Diseases 0.000 description 1
- FURUXTVZLHCCNA-UHFFFAOYSA-N Liquiritigenin Natural products C1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-UHFFFAOYSA-N 0.000 description 1
- 206010025421 Macule Diseases 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 208000019914 Mental Fatigue Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 101100113065 Mus musculus Cfi gene Proteins 0.000 description 1
- 206010028372 Muscular weakness Diseases 0.000 description 1
- 241000187479 Mycobacterium tuberculosis Species 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 208000007443 Neurasthenia Diseases 0.000 description 1
- 206010061876 Obstruction Diseases 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 206010033307 Overweight Diseases 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 206010033799 Paralysis Diseases 0.000 description 1
- 239000005643 Pelargonic acid Substances 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 240000004760 Pimpinella anisum Species 0.000 description 1
- 244000197580 Poria cocos Species 0.000 description 1
- 235000008599 Poria cocos Nutrition 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- 241000588767 Proteus vulgaris Species 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 244000086363 Pterocarpus indicus Species 0.000 description 1
- 235000009984 Pterocarpus indicus Nutrition 0.000 description 1
- 208000010378 Pulmonary Embolism Diseases 0.000 description 1
- 208000006193 Pulmonary infarction Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- LUJAXSNNYBCFEE-UHFFFAOYSA-N Quercetin 3,7-dimethyl ether Natural products C=1C(OC)=CC(O)=C(C(C=2OC)=O)C=1OC=2C1=CC=C(O)C(O)=C1 LUJAXSNNYBCFEE-UHFFFAOYSA-N 0.000 description 1
- PUTDIROJWHRSJW-UHFFFAOYSA-N Quercitrin Natural products CC1OC(Oc2cc(cc(O)c2O)C3=CC(=O)c4c(O)cc(O)cc4O3)C(O)C(O)C1O PUTDIROJWHRSJW-UHFFFAOYSA-N 0.000 description 1
- 206010038084 Rectocele Diseases 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 206010038776 Retching Diseases 0.000 description 1
- 241000206572 Rhodophyta Species 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- ZONYXWQDUYMKFB-UHFFFAOYSA-N SJ000286395 Natural products O1C2=CC=CC=C2C(=O)CC1C1=CC=CC=C1 ZONYXWQDUYMKFB-UHFFFAOYSA-N 0.000 description 1
- 206010039424 Salivary hypersecretion Diseases 0.000 description 1
- JMFSHKGXVSAJFY-UHFFFAOYSA-N Saponaretin Natural products OCC(O)C1OC(Oc2c(O)cc(O)c3C(=O)C=C(Oc23)c4ccc(O)cc4)C(O)C1O JMFSHKGXVSAJFY-UHFFFAOYSA-N 0.000 description 1
- 241000195474 Sargassum Species 0.000 description 1
- 201000004239 Secondary hypertension Diseases 0.000 description 1
- 206010040904 Skin odour abnormal Diseases 0.000 description 1
- 208000032140 Sleepiness Diseases 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 108010023197 Streptokinase Proteins 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010042434 Sudden death Diseases 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 206010042727 Swollen tongue Diseases 0.000 description 1
- 241000244155 Taenia Species 0.000 description 1
- 208000003217 Tetany Diseases 0.000 description 1
- 206010070863 Toxicity to various agents Diseases 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 description 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- 229930003448 Vitamin K Natural products 0.000 description 1
- MOZJVOCOKZLBQB-UHFFFAOYSA-N Vitexin Natural products OCC1OC(Oc2c(O)c(O)cc3C(=O)C=C(Oc23)c4ccc(O)cc4)C(O)C(O)C1O MOZJVOCOKZLBQB-UHFFFAOYSA-N 0.000 description 1
- 208000005946 Xerostomia Diseases 0.000 description 1
- 208000031971 Yin Deficiency Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- OQWKEEOHDMUXEO-BQYQJAHWSA-N [6]-Shogaol Chemical compound CCCCC\C=C\C(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-BQYQJAHWSA-N 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- OXGUCUVFOIWWQJ-XIMSSLRFSA-N acanthophorin B Natural products O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-XIMSSLRFSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 208000036981 active tuberculosis Diseases 0.000 description 1
- 208000005298 acute pain Diseases 0.000 description 1
- 210000000577 adipose tissue Anatomy 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003470 adrenal cortex hormone Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000003797 alkaloid derivatives Chemical class 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
- 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
- 230000006986 amnesia Effects 0.000 description 1
- 229940025084 amphetamine Drugs 0.000 description 1
- 229940025131 amylases Drugs 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000002429 anti-coagulating effect Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 230000002155 anti-virotic effect Effects 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940127088 antihypertensive drug Drugs 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 239000010692 aromatic oil Chemical class 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 208000021328 arterial occlusion Diseases 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 208000003464 asthenopia Diseases 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 208000015294 blood coagulation disease Diseases 0.000 description 1
- 230000037237 body shape Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- 210000000621 bronchi Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 229960001948 caffeine Drugs 0.000 description 1
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 1
- 230000036996 cardiovascular health Effects 0.000 description 1
- 210000000748 cardiovascular system Anatomy 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 206010008118 cerebral infarction Diseases 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 description 1
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- MDZKJHQSJHYOHJ-UHFFFAOYSA-N crataegolic acid Natural products C1C(O)C(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MDZKJHQSJHYOHJ-UHFFFAOYSA-N 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- KQILIWXGGKGKNX-UHFFFAOYSA-N dihydromyricetin Natural products OC1C(=C(Oc2cc(O)cc(O)c12)c3cc(O)c(O)c(O)c3)O KQILIWXGGKGKNX-UHFFFAOYSA-N 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 208000016097 disease of metabolism Diseases 0.000 description 1
- 230000001882 diuretic effect Effects 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 235000005686 eating Nutrition 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 208000026500 emaciation Diseases 0.000 description 1
- 230000007368 endocrine function Effects 0.000 description 1
- 239000002158 endotoxin Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 238000001976 enzyme digestion Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 235000020774 essential nutrients Nutrition 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229940012952 fibrinogen Drugs 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 206010016766 flatulence Diseases 0.000 description 1
- 229930003949 flavanone Natural products 0.000 description 1
- 150000002208 flavanones Chemical class 0.000 description 1
- 235000011981 flavanones Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 150000002256 galaktoses Chemical class 0.000 description 1
- 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 208000018997 giddiness Diseases 0.000 description 1
- 230000004110 gluconeogenesis Effects 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000008821 health effect Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 235000009200 high fat diet Nutrition 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- NQYPTLKGQJDGTI-FCVRJVSHSA-N hyperoside Natural products OC[C@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3[C@H]2O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@H]1O NQYPTLKGQJDGTI-FCVRJVSHSA-N 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- JBQATDIMBVLPRB-UHFFFAOYSA-N isoliquiritigenin Natural products OC1=CC(O)=CC=C1C1OC2=CC(O)=CC=C2C(=O)C1 JBQATDIMBVLPRB-UHFFFAOYSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 208000006443 lactic acidosis Diseases 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 201000002364 leukopenia Diseases 0.000 description 1
- 231100001022 leukopenia Toxicity 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 235000005955 light diet Nutrition 0.000 description 1
- 229960004488 linolenic acid Drugs 0.000 description 1
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
- 229920006008 lipopolysaccharide Polymers 0.000 description 1
- FURUXTVZLHCCNA-AWEZNQCLSA-N liquiritigenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC=C2C(=O)C1 FURUXTVZLHCCNA-AWEZNQCLSA-N 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- MDZKJHQSJHYOHJ-LLICELPBSA-N maslinic acid Chemical compound C1[C@@H](O)[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MDZKJHQSJHYOHJ-LLICELPBSA-N 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000037323 metabolic rate Effects 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 239000002366 mineral element Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 230000002107 myocardial effect Effects 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- DFPMSGMNTNDNHN-ZPHOTFPESA-N naringin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC=2C=C3O[C@@H](CC(=O)C3=C(O)C=2)C=2C=CC(O)=CC=2)O[C@H](CO)[C@@H](O)[C@@H]1O DFPMSGMNTNDNHN-ZPHOTFPESA-N 0.000 description 1
- 229930019673 naringin Natural products 0.000 description 1
- 229940052490 naringin Drugs 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 229960002446 octanoic acid Drugs 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 201000008482 osteoarthritis Diseases 0.000 description 1
- 235000020830 overeating Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- VDYCLYGKCGVBHN-UHFFFAOYSA-N pachymaic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC(=C)C(C)C)C(O)=O)C(O)CC21C VDYCLYGKCGVBHN-UHFFFAOYSA-N 0.000 description 1
- SRDNLMOBFKJOSD-UHFFFAOYSA-N pachymic acid Natural products CC12CCC(OC(C)=O)C(C)(C)C1CCC1=C2CCC2(C)C(C(CCC=C(C)C)C(O)=O)C(O)CC21C SRDNLMOBFKJOSD-UHFFFAOYSA-N 0.000 description 1
- 210000001819 pancreatic juice Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 229940067631 phospholipid Drugs 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- 239000003075 phytoestrogen Substances 0.000 description 1
- 239000008104 plant cellulose Substances 0.000 description 1
- 229940012957 plasmin Drugs 0.000 description 1
- 206010036067 polydipsia Diseases 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000013406 prebiotics Nutrition 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 235000013324 preserved food Nutrition 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 229940007042 proteus vulgaris Drugs 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000007575 pulmonary infarction Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- OVSQVDMCBVZWGM-DTGCRPNFSA-N quercetin 3-O-beta-D-galactopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-DTGCRPNFSA-N 0.000 description 1
- OEKUVLQNKPXSOY-UHFFFAOYSA-N quercetin 3-O-beta-D-glucopyranosyl(1->3)-alpha-L-rhamnopyranosyl(1->6)-beta-d-galactopyranoside Natural products OC1C(O)C(C(O)C)OC1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OEKUVLQNKPXSOY-UHFFFAOYSA-N 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 description 1
- BBFYUPYFXSSMNV-UHFFFAOYSA-N quercetin-7-o-galactoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 BBFYUPYFXSSMNV-UHFFFAOYSA-N 0.000 description 1
- OXGUCUVFOIWWQJ-HQBVPOQASA-N quercitrin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OXGUCUVFOIWWQJ-HQBVPOQASA-N 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 208000010540 rapid respiration Diseases 0.000 description 1
- 230000009103 reabsorption Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 201000003068 rheumatic fever Diseases 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 102220187652 rs138914132 Human genes 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 208000026451 salivation Diseases 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 229930004725 sesquiterpene Natural products 0.000 description 1
- 150000004354 sesquiterpene derivatives Chemical class 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037321 sleepiness Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- GSZUGBAEBARHAW-UHFFFAOYSA-N sophoraflavone B Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C(C=2OC3=CC(O)=CC=C3C(=O)C=2)C=C1 GSZUGBAEBARHAW-UHFFFAOYSA-N 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 description 1
- 208000024794 sputum Diseases 0.000 description 1
- 210000003802 sputum Anatomy 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 229960005202 streptokinase Drugs 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000006277 sulfonation reaction Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- 235000019605 sweet taste sensations Nutrition 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 235000014620 theaflavin Nutrition 0.000 description 1
- 229940026510 theanine Drugs 0.000 description 1
- 229930007110 thujone Natural products 0.000 description 1
- 230000006016 thyroid dysfunction Effects 0.000 description 1
- 230000003867 tiredness Effects 0.000 description 1
- 208000016255 tiredness Diseases 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 150000003648 triterpenes Chemical class 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 210000005239 tubule Anatomy 0.000 description 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- SGEWCQFRYRRZDC-VPRICQMDSA-N vitexin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1C1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O SGEWCQFRYRRZDC-VPRICQMDSA-N 0.000 description 1
- PZKISQRTNNHUGF-UHFFFAOYSA-N vitexine Natural products OC1C(O)C(O)C(CO)OC1OC1=C(O)C=C(O)C2=C1OC(C=1C=CC(O)=CC=1)=CC2=O PZKISQRTNNHUGF-UHFFFAOYSA-N 0.000 description 1
- 210000004916 vomit Anatomy 0.000 description 1
- 208000016261 weight loss Diseases 0.000 description 1
- 239000013585 weight reducing agent Substances 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/066—Clavicipitaceae
- A61K36/068—Cordyceps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/82—Theaceae (Tea family), e.g. camellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/04—Drugs for disorders of the respiratory system for throat disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Anesthesiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
Abstract
The invention discloses a traditional Chinese medicine stock solution mixture. The formula synthesis comprises: 180g of seaweed, 160g of dried orange peel, 800mg of cordyceps militaris, 190g of ampelopsis grossedentata tea, 180g of dendrobium, 160g of pummelo peel, 30g of red date, 90g of white poria, 16g of dried pawpaw seed, 15g of dried pineapple flower, 60g of hawthorn, 90g of astragalus, 80g of dried liquorice, 80g of mulberry, 20g of black fungus, 60g of dried ginger, 30g of wormwood and 90g of green tea. The preparation method comprises the following steps: decocting the raw materials in water for four times, mixing, filtering, and extracting twice by distillation. The curative effect is as follows: 1. the oral preparation can be used for treating symptoms caused by metabolic syndrome of human body, has no side effect, and is suitable for treating obesity, insomnia, alopecia, edema, gastritis, diabetes, hypertension, hyperglycemia, hyperlipidemia, gout, tumor, numbness, vertigo, halitosis, constipation, etc. 2. The external preparation has effects of sterilizing, diminishing inflammation, relieving itching and detumescence, has no harm to human skin, and is suitable for treating corner ulcer, oral ulcer, toothache, acne, nasopharyngitis, pruritus, wound inflammation, paronychia, onychomycosis, tinea pedis, bromhidrosis, foot odor, hemorrhoid, etc. The using method comprises the following steps: the oral administration is 30ml, the oral administration is divided into 2 times, the effect is achieved within one week, and the cure can be realized in one to two treatment courses; 2. can be applied for many times for external use, has effect in one day, and can be cured in three to five days.
Description
Technical Field
A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation is provided. The Chinese medicinal raw liquid mixture has the following curative effects:
the medicine is taken orally to treat the symptoms caused by human metabolic syndrome without side effect.
Oral administration: treating phlegm dampness obesity, insomnia, alopecia, edema, gastritis, diabetes, hypertension, hyperglycemia, hyperlipidemia, gout, tumor, numbness, vertigo, halitosis, constipation, etc. caused by metabolism syndrome disorder.
Secondly, the external use has the functions of sterilization, inflammation diminishing, sterilization, itching relieving and swelling diminishing, and has no harm to the skin of the human body.
External use: has antibacterial, antiinflammatory, antipruritic, and repercussive effects, and is suitable for treating corner ulcer, oral ulcer, toothache, acne, nasopharyngitis, pruritus, wound inflammation, paronychia, onychomycosis, tinea pedis, bromhidrosis, foot odor, and hemorrhoid.
The invention relates to a group of traditional Chinese medicine formulas, belonging to the technical field of traditional Chinese medicine preparation stock solution mixture for oral administration and external use.
Background
The pathological state of the human metabolic disorder is also a complex group of metabolic syndromes and has the following characteristics:
firstly, the human body is obese due to phlegm-dampness constitution. Mainly refers to the dysfunction of human viscera, which easily causes the dysfunction of transportation and transformation of qi, blood and body fluids, water-dampness accumulation and accumulation of dampness to form phlegm-body obesity, often forms obesity, abdominal fullness, chest distress, excessive phlegm, easy drowsiness, swollen tongue, white and greasy tongue coating, easy thirst, apoplexy, chest impediment and the like, and has poor adaptability to plum rain and damp heavy environment. People with wet constitution can not eat fat, sweet, thick and cold raw materials, stop smoking, improve the intake of rich fiber and vitamins, and keep defecate smooth and normal. The dried pineapple flowers, the dried pawpaw seeds, the mulberry, the astragalus, the dried liquorice, the white poria, the dried tangerine peel, the pummelo peel, the red dates and the wormwood are as follows: rich in fiber and vitamins, has effects of promoting defecation, invigorating spleen, eliminating phlegm, and promoting qi and blood circulation. The spleen is the source of phlegm generation, and the lung is the device for storing phlegm, so that the spleen is strengthened, phlegm is reduced, wading rain is avoided, people stay in the wet land for a long time, the people pay attention to heat preservation, the spleen is prevented from being injured by external cold-dampness, and the spleen is prevented from being trapped, and the people are suitable for physical exercise and are smooth in qi and blood due to slight sweat.
Secondly, facial wrinkles and dull complexion. The skin is influenced by the external environment and the skin itself to form free radicals, the free radicals destroy collagen and active substances in normal cell membrane tissues, the collagen content of the skin dermis layer is gradually reduced, the reticular supporting body is thickened, hardened and loses elasticity, the elasticity and the water retention degree of the dermis layer are reduced, the skin loses elasticity, becomes thin and ages, the skin becomes loose and wrinkles appear due to the reduction of fat of the fat pad under the eyelid, and no matter the wrinkles, the fishtail lines, the fine lines and the eye tail lines are all caused by the uneven collapse of the skin epidermis. When a human body enters the canthus at about 25 years old, shallow small wrinkles and eye bags may appear; the forehead wrinkles deepen and increase around 25 years old, and the external canthus has fishtail lines and the upper eyelid skin has wrinkles; the nasolabial sulcus deepens when the patient is aged 40 years, fine wrinkles appear at the corners of the mouth, and wrinkles appear at the neck; the 50 year old eye bags deepen and appear with lower eyelid lines, and the upper and lower lips also appear with wrinkles; the elasticity of the face is reduced and the wrinkles are deepened by the age of 60. When the collagen content in the skin is gradually reduced, the dermal fiber is broken, the lipoatrophy, the sweat gland and sebaceous gland secretion is reduced, and the skin has the aging phenomena of color spots, tarnish, looseness, wrinkles and the like. Seaweed, astragalus, dried liquorice, white poria, dried tangerine peel, cordyceps militaris, pummelo peel, red dates, hawthorn, dried ginger, ampelopsis grossedentata tea, wormwood, green tea and dendrobium nobile supply sufficient skin nutrition, subcutaneous tissues are full, collagen connective tissues are adopted, skin is lubricated, and wrinkles are removed. Green tea contains more than 400 kinds of abundant chemical components, mainly contains tea, phenols, aromatic oil compounds, carbohydrates, proteins, various amino acids, vitamins, minerals, pectin and the like. Is a natural body-building beverage, can promote health, keep skin smooth and clean, delay facial wrinkles, support skin cells, and achieve the effects of removing wrinkles, whitening skin, removing freckles, removing pouches and the like.
Third, face edema, acne, fatigue, soreness of the waist and back pain. The kidney manages the running of liquid in the body, and after toxin is accumulated on the kidney, the capacity of discharging redundant liquid is reduced, so that edema occurs; the kidney of the lower jaw part of the face is controlled, the toxin expelling of the kidney is insufficient, the redundant toxin can be shown in the lower jaw part, and the lower jaw has acne; the energy of the kidney is consumed by toxins in the body, and the energy supplied by the kidney is reduced, so that the symptoms of tiredness, mental fatigue, sleepiness, weakness of limbs, soreness of waist and back pain appear. Cordyceps has effects of invigorating kidney, nourishing liver, replenishing essence, improving eyesight, strengthening tendons and bones, relieving lumbago, replenishing essence, and strengthening tendons and bones, and can be used for treating asthenia, emaciation, lassitude, giddiness, deafness, dim eyesight, and soreness of waist and knees. The agaric can ensure the metabolism of the kidney, reduce the accumulation of redundant water in the kidney, the vegetable protein is beneficial to the kidney, and the phytoestrogen has the effect of protecting the kidney; the astragalus, the dried liquorice, the white poria, the dried orange peel, the cordyceps militaris, the pummelo peel, the red dates, the hawthorns, the dried ginger, the ampelopsis grossedentata tea, the wormwood, the green tea and the dendrobium have the effects of nourishing blood and liver, securing essence and tonifying the kidney, strengthening bones and muscles, blackening hair and improving eyesight, filling blood, building walking, soreness and pain in the waist and back, weak feet and knees and the like.
In diabetes, such as insulin deficiency, glucose entering tissue cells is reduced, and hepatic glycogen breakdown and xenogenesis are enhanced. Glucose released into the blood by the liver increases greatly, blood glucose levels rise and are excreted from the urine beyond the renal glucose threshold, manifesting as diabetes. Dried pineapple flowers, dried pawpaw seeds, mulberry, black fungus, seaweed, astragalus, dried liquorice, white poria, dried tangerine peel, cordyceps militaris, pummelo peel, red dates, hawthorn, dried ginger, maoyanmei tea, wormwood, green tea and dendrobium contain bicarbonate and various digestive enzymes for exocrine pancreatic juice of pancreas, neutralize gastric acid, and digest sugar, protein and fat. 1. Promotes the synthesis of liver glycogen and muscle glycogen, which is mainly achieved by increasing the activity of glycogen synthase in the liver and muscle. 2. Promoting glucose to enter muscle and fat tissue cells. 3. The glucolase is activated to produce glucose-6-phosphate. 4. Inhibiting gluconeogenesis. Prevention: abstinence from alcohol, overeating, light diet, eating carbohydrates and proteins.
And fifthly, halitosis, macula pox and constipation, which means that many people have no intention to lift after defecating, harmful bacteria in intestines accumulate for a long time, and the harmful bacteria continuously utilize the harmful bacteria to generate toxic substances, so that the large intestine full of foul smell is formed. Halitosis is a gas produced by abnormal fermentation in the intestine, a gas that enters the blood from the large intestine and is then transported to the lungs, and is discharged from the mouth together with respiration, causing halitosis; the constipation is called as 'origin of diseases', the constipation directly increases the stool of the intestinal tract, the stool produces various toxins, generally about 40 hundred million toxins, and when the number of harmful toxins reaches 200 million, the intestinal tract movement is hindered, the intestinal peristalsis and the swinging of intestinal villi are weakened, the feces stagnate and start to decay in the intestine, and the produced harmful substances are absorbed by the intestine, and then the toxins gradually appear on the naked skin of the human body in the morning and the evening, such as color spots and dark skin on the hands, the health condition of the intestinal tract is known by observing the complexion, and acne is generated on the face with low immunity, namely acne, and a lot of diseases are caused. The five zang organs descend qi to regulate the middle energizer, but do not have lung qi, so the lung and large intestine meridians are communicated to moisten the intestines for relaxing bowels; tonify kidney qi, kidney qi deficiency, blood vessel is not alive. The dried orange peel, cordyceps militaris, pummelo peel, red date, hawthorn, dried ginger, ampelopsis grossedentata tea, wormwood, dendrobium, mulberry, green tea and seaweed are added with plant cellulose, are rich in oil, supplement prebiotics, clear heat, moisten intestines, detoxify, relieve lung qi, supplement kidney qi, clear heat, resolve phlegm, remove food retention, moisten intestines, digest, expel toxin and defecate.
Sixthly, when the user sleeps, the mouth is flushed on one side, the head is dizzy, the limbs are swollen, the chest is stuffy and painful, the body breathes and the heartbeat are rapid, and the upper signals are sent out by the body, which indicates that the thrombus and blood clots are formed in the blood vessels. The blood clots are called thrombus, and block the blood vessels of different parts of the body like plugs, so that once the blood vessels are blocked, the blood transportation system is paralyzed, the related visceral organs have no blood supply, sudden death is caused, and the life and health are seriously threatened. Specifically, the method comprises the following steps: 1. when sleeping, the saliva flows on one side, because thrombus can cause dysfunction of the pharyngeal cavity muscles. 2. Dizziness in the head, which is the most typical symptom of cerebral thrombosis precursor, is very common, and can occur at any time before cerebrovascular disease, especially when getting up in the morning, and also easily occurs after fatigue and bathing, especially in hypertension patients, if dizziness occurs more than 5 times repeatedly in 1-2 days, the risk of cerebral hemorrhage or cerebral infarction is increased. 3. Swelling of the extremities, which is one of the typical symptoms of deep vein thrombosis, is especially noted when rapid swelling and pain in the thighs occurs. Swelling occurs over time because of the thrombus which can cause the blood flow in the legs to be blocked. 4. Chest distress and pain, and long-term lack of motion can easily cause blood to form venous clots. Furthermore, blood clots may break off, following the blood flow into the lungs. If the thrombus is larger or more, the thrombus can be blocked on the branch or trunk of the pulmonary artery, large-area pulmonary infarction is caused, discomfort such as chest distress, chest pain, cough, respiratory obstruction and the like occurs, and the life can be seriously threatened. 5. The patient feels that the chest and heart beat are accelerated and the breath becomes shallow due to rapid respiration and heartbeat, which are signals for asking for help of the body, and the lung meets the pulmonary embolism and seriously falls down. The health food contains fructus Ananadis Comosi dried flower, fructus Chaenomelis dried seed, Mori fructus, pericarpium Citri Tangerinae, scarlet caterpiller fungus, exocarpium Citri Grandis, fructus Jujubae, fructus crataegi, Zingiberis rhizoma, fructus Jujubae, Sargassum, Auricularia, and green tea, and can inhibit absorption of cholesterol by human body and regulate blood lipid; the n-3 fatty acid, folic acid and potassium can keep artery vessel smooth and is beneficial to heart. The polyphenol substance, anthocyanin, helps to promote blood circulation and metabolism, and actively transmit to the whole body to enhance endocrine function. The sulfated polysaccharide can absorb cholesterol in blood vessel and discharge it to outside of body, so as to keep cholesterol in blood at normal content, and is rich in dietary fiber and colloid, and the colloid component can combine with harmful substances in blood, such as heavy metal, and has effects of removing toxic substance, purifying blood, and improving blood vessel patency.
Seventhly, enzyme digestion, thrombus prevention and treatment, inflammation diminishing and sterilization. The human body contains more than 700 kinds of enzymes distributed in the oral cavity, gastrointestinal tract, pancreas, liver, muscle and skin of the human body, and with the age, the enzymes in other parts of the body are consumed in metabolism, and the enzymes are needed for other body organs and systems to normally function, and the harm to the health of the body is larger when the more the enzymes are consumed. The dried pineapple flowers, the dried pawpaw seeds, the mulberry, the black fungus, the seaweed, the astragalus mongholicus, the dried liquorice, the white poria, the dried tangerine peel, the cordyceps militaris, the pummelo peel, the red dates, the hawthorn, the dried ginger, the maoyanmei tea, the wormwood, the green tea and the dendrobium have the following effects: proteases convert proteins to amino acids, amylases convert starch to glucose, and lipases break down fats to fatty acids. And (3) nutrition generation: nutrients such as saccharides, organic acids, minerals, vitamins, phenols, terpenes, etc.; physiologically active substance: vitamins, amino acids, polysaccharides, peptides, polyphenols, flavonoids, mineral elements and organic acids, antioxidant components such as GABA, SOD, catalase, etc., and antioxidant components such as probiotics and microorganisms such as flavonoids, isoflavones, saponin, etc. The specific effects are as follows: 1. helping digestion. (1) Digestive enzymes-flatulence, nausea. (2) Improving immunity. (3) The enzyme can promote effective metabolism, avoid pseudo-hunger generated by digestion, and naturally and stably reduce weight. (4) Digestive enzymes promote cardiovascular health. Reduce the formation of arterial obstruction of fat precipitation, protease, trypsin, papain, amylase, lipase can all help digestion. 2. Can be used for preventing and treating thrombosis. Streptokinase, urokinase and plasmin can dissolve thrombus and prevent thrombosis, and can be used for treating cerebral thrombosis and myocardial infarction. 3. Diminishing inflammation and sterilizing. The health-care food is prepared from flavonoids, lysozyme, bromelain and papain, can relieve inflammation, promote detumescence and surgical sore removal, and is flavonoid, antioxidant, bactericidal and anti-inflammatory to provide organism immunity.
Disclosure of Invention
The invention provides a group of raw liquid mixtures prepared by traditional Chinese medicine formulas, which are used for treating human metabolic syndrome and related symptoms of sterilization and inflammation diminishing, and the traditional Chinese medicine raw liquid mixture has definite curative effect, is taken orally and has no toxic or side effect; it is applied externally and has no damage to skin.
The parts are mass parts, and are microgram, milligram, gram, kilogram and other mass units commonly used in the field.
A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation is provided. The technical scheme of the formula adopted by the invention is as follows: the tea is prepared from the following raw materials of dried pineapple flowers, dried pawpaw seeds, mulberry, black fungus, seaweed, astragalus mongholicus, dried liquorice, white poria, dried orange peel, cordyceps militaris, pummelo peel, red dates, hawthorn, dried ginger, maoyanmei tea, wormwood, green tea and dendrobium by mass: 320 parts of seaweed 180-.
A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation is provided. The preferable formula is synthesized, and specifically: 180g of seaweed, 160g of dried orange peel, 800mg of cordyceps militaris, 190g of ampelopsis grossedentata tea, 180g of dendrobium, 160g of pummelo peel, 30g of red date, 90g of white poria, 16g of dried pawpaw seed, 15g of dried pineapple flower, 60g of hawthorn, 90g of astragalus, 80g of dried liquorice, 80g of mulberry, 20g of black fungus, 60g of dried ginger, 20g of wormwood and 90g of green tea.
A Chinese medicinal oral and topical stock solution mixture for treating human metabolic syndrome and resisting bacteria and inflammation is prepared by: decocting the raw materials in water for four times: adding 10 times of water for the first time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 8 times of water for the second time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 6 times of water for the third time, boiling for 2 hr, and decocting with slow fire for 4 hr; adding 5 times of water for the fourth time, boiling for 1 hr, decocting with slow fire for 4 hr, mixing decoctions, and sieving with 300-mesh 400-mesh filter screen to obtain the final product. Putting the filter screen decoction into a multifunctional traditional Chinese medicine extraction tank, extracting by adopting a steam distillation method, putting Cordyceps militaris and herba Dendrobii powder bags (1 g of Cordyceps militaris and 200g of herba Dendrobii) while decocting, distilling, condensing, collecting distillation stock solution (2 times by distillation method), and filling.
The oral administration and external application method of the stock solution mixture has the daily dose of 30ml, and the stock solution mixture is taken by 2 times, specifically 15ml (about 80ml of white boiled water in a half cup and 50-60 ℃) respectively taken by half an hour after lunch in the morning on an empty stomach. Oral administration: in the aspect of treating symptoms caused by human metabolic syndrome, 20 days are taken as a treatment course, the effect is usually achieved within one week, and the symptoms can be cured in one to two treatment courses; external use: has the effects of sterilizing, diminishing inflammation, relieving itching and reducing swelling, and can be cured in three to five days.
The formula is as follows:
the dried pineapple flowers are neutral in nature, sweet in taste, slightly sour, slightly astringent and slightly cold in nature, and have the curative effects of promoting digestion, relieving diarrhea, tonifying spleen and stomach, strengthening vitality, tonifying qi and blood, promoting digestion, eliminating dampness and treating constipation. Among them, bromelain decomposes proteins, helps digestion, dissolves fibrin and blood clots that block tissues, improves blood circulation, dilutes blood lipids, eliminates inflammation and edema, promotes blood circulation, and prevents fat deposition. The enzyme can decompose protein in stomach, supplement digestive enzyme deficiency in human body, and prevent gel aggregation, so as to restore normal digestive function for people with dyspepsia. In addition, sugar and enzyme contained in pineapple have a certain diuretic effect, and are beneficial to nephritis and hypertension patients, and also have adjuvant therapeutic effect on bronchitis and therapeutic effect on constipation by cellulose. Besides, the pineapple is rich in vitamin B1, and can promote metabolism, relieve fatigue and reduce the incidence of cardiovascular and cerebrovascular diabetes.
The papaya seed dried food contains papaya protease, carotene and vitamin C, has antioxidant capacity, helps organism repair tissue, eliminates toxic substances, and enhances immunity. Specifically, the method comprises the following steps: 1. supplementing nutrition, and fructus Chaenomelis contains large amount of water, carbohydrate, protein, fat, multiple vitamins and amino acids, and can supplement nutrition and enhance antivirus ability of human body. 2. The food has the effects of invigorating spleen to promote digestion, and decomposing fat into fatty acid and decomposing protein into amino acid by using papain, thereby facilitating digestion and absorption of food by human body. 3. Antibacterial effect, and has effects in resisting Bacillus tuberculosis and killing parasite. 4. Has antispasmodic effect, and can relieve spasm pain symptom and has obvious effect on gastrocnemius spasm.
Mulberry, cold in nature, produces saliva, contains tannic acid, fatty acid, malic acid, fatty acid, linoleic acid, stearic acid, vitamins, carotene and trace elements. Comprising: improving blood supply of skin (including scalp), nourishing skin, whitening skin, blackening hair, delaying aging, improving eyesight, relieving eye fatigue and dryness, enhancing spleen and hemolytic reaction, preventing arteriosclerosis and skeleton arthrosis, promoting metabolism, promoting red blood cell growth, preventing leukopenia, and treating diabetes, anemia, hypertension, hyperlipemia, coronary heart disease, neurasthenia, etc. Specifically, the method comprises the following steps: 1. the fatty acids in mulberry mainly comprise linoleic acid, oleic acid, palmitic acid, stearic acid and a small amount of caprylic acid, pelargonic acid, capric acid, myristic acid, linolenic acid and the like, and have the effects of decomposing fat, reducing blood fat, preventing angiosclerosis and the like. 2. The mulberry contains tannic acid, fatty acid, malic acid and the like, helps digestion of fat, protein and starch, has the functions of strengthening spleen and stomach and helping digestion, and is used for treating diarrhea caused by dyspepsia. 3. The nutritious mulberry contains abundant vitamins, carotene and trace elements, and can effectively expand blood volume of human body, and is suitable for patients with hypertension and women. 4. Mulberry contains hair blackening agent, and can make hair black and bright.
Black fungus, nature and taste: sweet, mild and non-toxic. Comprising: nourishing, moistening dryness, nourishing blood, benefiting stomach, promoting blood circulation, stopping bleeding, moistening lung, and moistening intestine, and can be used for treating hyperlipidemia, invigorating qi, relieving hunger, treating hemorrhoid, relaxing muscles and tendons, activating collaterals, blood deficiency, qi deficiency, tetany, cough due to lung deficiency, bloody dysentery, and tranquilizing mind and relieving pain. The Auricularia polysaccharide has radioprotective effect superior to that of Tremella polysaccharide, and can resist leukocyte decrease caused by cyclophosphamide. The proteins, fats and saccharides contained in the black fungus are not only essential nutrient components for human bodies, but also material bases for beautifying. The carotene is converted into vitamin A after entering human body, which has the function of moistening skin and hair, the lecithin can make the fat in the body in a liquid state, which is beneficial to the complete consumption of the fat in the body and the drive of the fat in the body to move, so that the fat is distributed reasonably and has a uniform body shape. The cellulose can promote enterokinesia and fat excretion, and is beneficial for weight reduction.
Seaweed, nature and taste, bitter, salty, cold, nontoxic. Improve lung, spleen, kidney, liver and stomach, and has the following effects: softening hard mass, eliminating phlegm, promoting diuresis, relieving swelling, abdominal mass, distending pain, hollow belly, edema, and treating skin accumulation, stagnation of qi, heat accumulation, diuresis, and loempe. Specifically, the method comprises the following steps: 1. the carrageenans of red algae are sulfated galactose polymers, and these polysaccharides have the effect of enhancing immunity. 2. Dietary fiber. The dietary fiber is macromolecule with polysaccharide structure, is main component constituting seaweed cell wall, and has effects of improving hyperlipemia symptoms, inhibiting blood cholesterol content, regulating and controlling blood sugar amount, increasing intake of seaweed fiber, lowering blood pressure, blood cholesterol and blood sugar amount, and protecting heart and blood vessel. 3. Vitamins: when a certain vitamin is deficient or deficient in a human body, metabolic disorder or disease is caused, and the seaweed contains various vitamins (vitamins B12, C and E, biotin and nicotinic acid), so that the deficiency of iodine in the human body is improved to cause thyroid dysfunction. 4. A fatty acid. Fatty acids are usually present in the deep sea algae in high amounts, and can help to lower blood pressure, heartbeat and relieve stress, and can also inhibit blood cholesterol level increase and platelet aggregation, prevent thrombosis and myocardial infarction, and prevent arteriosclerosis and circulatory system diseases. 5. Alginic acid sulfonic acid has anticoagulant and hemostatic effects. The alginic acid can prevent blood coagulation disorder after sulfonation, and has anticoagulant and topical hemostatic effects. 6. Alginic acid and amphetamine with equal molecules can relieve obesity without causing insomnia, and eliminate body odor, foot odor and other unpleasant odors.
Huang Qi is sweet in flavor and slightly warm in nature. The astragalus contains calycosin, 3-hydroxy-9, 10-dimethoxy rosewood alkane and astragalus saponin, and has the main functions of treating spleen and lung: invigorating qi, consolidating superficial resistance, removing toxic substances, expelling pus, promoting urination, and promoting granulation. Can be used for treating deficiency of vital energy, asthenia, chronic diarrhea, rectocele, spontaneous perspiration, edema, chronic nephritis, albuminuria, diabetes, and unhealed wound.
Dried liquorice, dried liquorice root and rhizome, sweet taste and mild nature. Improving heart, lung, spleen and stomach channels, invigorating spleen and replenishing qi, clearing away heat and toxic materials, eliminating phlegm and relieving cough, and relieving spasm and pain. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature. Specifically, the method comprises the following steps: 1. it can be used for treating heart-qi deficiency, palpitation, intermittent pulse, spleen and stomach qi deficiency, listlessness, and asthenia. 2. It is used to treat carbuncle, ulcer, sore and sore throat. 3. Can be used for treating asthma and cough. 4. Can be used for treating stomach ache, abdominal pain, and acute pain of gastrocnemius muscle spasm. 5. The adrenocortical hormone has the effects of inhibiting hyperacidity caused by histamine, resisting acid and relieving gastrointestinal smooth muscle spasm. 6. Licoflavone, glycyrrhiza extract and glycyrrhetinic acid all have obvious cough relieving effect. 7. The Glycyrrhrizae radix has antiinflammatory and antiallergic effects, and can protect inflamed throat and trachea mucosa. 10. Licorice is commonly used to treat symptoms accompanying menopause because it contains liquiritigenin, a hormone-like compound that helps to balance the hormone content in women.
Poria cocos is sweet, light and flat in taste, improves heart, spleen, lung and kidney channels, has pachyman, B-pachyman, pachymic acid, lecithin, sterol and the like, and has the effects of excreting dampness and promoting diuresis, strengthening spleen and stomach, calming heart and tranquilizing mind, dysuria, edema and fullness, phlegm and fluid retention and cough, vomiting, spleen deficiency and poor appetite, diarrhea, palpitation and uneasiness, insomnia and amnesia. Poria has antibacterial effect, and pachyman complex have inhibiting and killing effects on Staphylococcus aureus, Escherichia coli, Bacillus proteus, etc.
Tangerine peel, pericarpium Citri Tangerinae, bitter in taste, pungent and warm in nature, enters lung and spleen meridians. Pericarpium Citri Tangerinae has pharmacological effects of treating stagnation of spleen and stomach qi, dampness obstruction, fullness and oppression in chest and diaphragm, abdominal pain, anorexia, emesis, constipation, obstruction of lung qi, cough, and excessive phlegm. Specifically, the method comprises the following steps: first, fullness and distention of chest and abdomen. 1. Tangerine peel, pericarpium Citri Reticulatae is pungent and fragrant in flavor, good at regulating qi, entering spleen and lung, promoting qi circulation and relieving epigastric distention, stagnation of lung qi, damp obstruction of middle energizer, abdominal distention, loose stool, diarrhea, excessive phlegm and cough. 2. Tangerine peel, pericarpium Citri Tangerinae and Poria are used together to strengthen the spleen and promote the circulation of qi, damp obstruction of middle energizer, abdominal distention and fullness, loose stool and greasy coating. 3. Can be used for treating spleen deficiency, anorexia, dyspepsia, nausea, and emesis. 4. Eliminating dampness and phlegm, phlegm-dampness obstructing the lung, fullness and oppression in chest and diaphragm, dizziness and vertigo. 5. Can be used for treating edema, dysuria, and constipation. Secondly, the function of the digestive system. The pericarpium Citri Tangerinae contains volatile oil, has mild irritation to gastrointestinal tract, and has effects of promoting secretion of digestive juice, eliminating intestinal tract pathogenic accumulation, invigorating stomach, dispelling pathogenic wind, and descending qi. And thirdly, the effect on the cardiovascular system. The pectin in pericarpium Citri Tangerinae has certain effect in preventing arteriosclerosis caused by high fat diet. And fourthly, the effect on a respiratory system. The pericarpium Citri Tangerinae volatile oil has effects of eliminating phlegm, relieving asthma, and slightly dilating bronchus. Fifth, the action on the urogenital system can cause the renal blood vessels to contract, so that the urine volume is normal. Sixthly, the anti-inflammatory effect is achieved, and the tangerine peel vitamin C and the vitamin K can enhance the anti-inflammatory effect. And influence on blood fat, and the tangerine peel pectin has the effect of reducing hyperlipidemia.
Cordyceps militaris is sweet and neutral in taste, and enters lung and kidney meridians, and has the effects of tonifying deficiency, benefiting vital essence, relieving cough and reducing sputum. The cordyceps militaris contains about 7 percent of cordycepic acid, about 25 percent of protein and about 8.4 percent of fat, wherein 82.2 percent of the cordycepic acid is unsaturated fatty acid which cannot be synthesized by a human body and is necessary, 28.9 percent of carbohydrate, 12 free amino acids, 18 hydrolysate amino acids, 8 amino acids which are necessary for the human body and histidine which is necessary for the growth and development of children. In addition, cordycepic acid, cordycepin, amino acids, sterol, mannitol, alkaloid, vitamin B1, B2, polysaccharide and minerals have effects of nourishing kidney, resisting arrhythmia, relieving fatigue, eliminating phlegm and relieving asthma, tranquilizing, hypnotizing, resisting bacteria, resisting inflammation and regulating immunity.
Exocarpium Citri Grandis, pungent and bitter in flavor, warm in nature, enters lung and spleen meridians, regulates qi, relieves epigastric distention, eliminates dampness and resolves phlegm. The pummelo peel mainly comprises flavanone, naringin and mutual peptide which are used for treating the diseases: cough with excessive phlegm, dyspepsia, alcoholic intoxication, nausea, distention, cold expelling, dampness eliminating, qi circulation promoting, diseases eliminating, cough relieving, spleen invigorating, digestion promoting, and cardiovascular and cerebrovascular health promoting effects.
The red date is sweet in taste and warm in nature, and has the functions of tonifying middle-jiao and Qi, nourishing blood and soothing nerves and relieving drug property, and spleen and stomach meridians are entered. The fructus Jujubae contains protein, saccharide, organic acid, vitamin A, vitamin C, various trace calcium and amino acids. Wherein, the flavonoids, the triterpenoids and the cyclic adenosine monophosphate have strong effects of inhibiting cancer, resisting allergy, resisting fatigue, damaging liver, lowering blood pressure, nourishing blood, calming the nerves, nourishing spleen and stomach, enhancing myocardial contractility and improving cardiac muscle.
Haw is sour and sweet in taste, slightly warm, and enters spleen, stomach and liver meridians. The fructus crataegi contains flavonoids, vitexin, quercetin, quercitrin, hyperoside, 7-glucoside, rutin, crataegolic acid, citric acid, ursolic acid, phospholipid, vitamin C, vitamin B2 and compounds. It can be used for treating dyspepsia, blood stasis, taenia, meat stagnation, abdominal mass, phlegm retention, acid regurgitation, dysentery, intestinal wind, lumbago, dyspepsia, abdominal pain, pain in heart and abdomen, and hyperlipidemia.
Gan Jiang is pungent in flavor and warm in nature and enters lung, stomach and spleen meridians. The main components are as follows: gingerol, shogaol, anis, borneol, gingerol, shogaone, zingerone and olein. The main treatment is as follows: relieving exterior syndrome, dispelling cold, warming middle warmer, relieving vomit, warming lung, relieving cough, promoting metabolism, dredging channels and collaterals, relieving stomach cold, anorexia, promoting gastric secretion, promoting digestion, invigorating stomach, promoting blood circulation, replenishing vital essence, improving eyesight, aversion to cold, lumbago, soreness of waist and knees, listlessness, ulcer, and gastritis due to deficiency-cold. Simultaneously has the functions of killing oral pathogenic bacteria and intestinal pathogenic bacteria and promoting blood circulation.
The mugwort is bitter, pungent and warm in taste, enters spleen, liver and kidney, is warm in nature, bitter in taste and nontoxic. It contains volatile oil, eucalyptol, thujone, sesquiterpene alcohol, fat, protein, biotin A, B1, B2, C, etc. Comprising: regulating qi and blood, dredging meridian passage, relieving swelling, dispersing pathogen accumulation, stopping bleeding, relieving inflammation, relieving asthma, relieving cough, resisting allergy, treating rheumatic arthritis, and resisting bacteria and inflammation.
Ampelopsis grossedentata tea containing 17 amino acids such as leucine, isoleucine, methionine, etc., and 14 microelements such as potassium, calcium, iron, zinc, magnesium, etc.; especially contains high-activity flavone and dihydromyricetin. The curative effect is as follows: 1. the flavone contained in the Ampelopsis grossedentata can eliminate harmful acid and ketone bodies of a human body, remove blood dirt in blood, regulate blood fat, reduce blood pressure, has obvious effect of softening blood vessels, can regulate renal tubule reabsorption, improve sleep, frequent micturition and the like 2. the flavone contained in the Ampelopsis grossedentata can sterilize bacteria, resist inflammation, clear away heat and toxic materials, relieve pain, reduce swelling, reduce fat and blood pressure, moisten throat, relieve cough and regulate and improve human immunity and has strong killing capability on staphylococcus aureus, streptococcus A, streptococcus B, diplococcus pneumoniae, bacillus influenzae and the like.
Green tea, tea polyphenols, catechins ECG, EGC and theaflavins. Comprising: refreshing, clearing away heart-fire, clearing away summer-heat, resolving food stagnation, eliminating phlegm, reducing weight, clearing heart-fire, relieving restlessness, removing toxic substance, relieving hangover, promoting salivation, quenching thirst, purging pathogenic fire, improving eyesight, relieving dysentery, removing dampness, and treating cardiovascular and cerebrovascular diseases. The main components of the tea beverage comprise tea polyphenol, caffeine, lipopolysaccharide and theanine. Comprising: delaying aging, resisting oxidation, scavenging free radicals, inhibiting cardiovascular diseases, and improving fat metabolism; the contents of cholesterol, triglyceride and the like are high, and the lipid-rich atherosclerosis-resistant tea has the effects of inhibiting atheromatous plaques formed after fat deposition on the inner wall of a blood vessel and proliferation of smooth muscle cells of the blood vessel, reducing fibrinogen with enhanced blood coagulation viscosity and clearing blood coagulation, thereby inhibiting atherosclerosis and virus resistance.
Dendrobium nobile, sweet in flavor and slightly cold in nature, enters stomach and kidney meridians. The main components are as follows: dendrobine, dendrostelline, dendrobine, 6-hydroxydendrobine, fresh dendrostelline, mucilaginous substance, starch, dendrobine, N-methyl dendrobine, and dendrobine. Has the following treatment: benefiting stomach and promoting fluid production, nourishing yin and clearing heat, fever and body fluid impairment, xerostomia and polydipsia, stomach yin deficiency, anorexia and retching, dim and unclear vision, flaccidity of tendons and bones, and the like.
Detailed Description
The invention relates to a traditional Chinese medicine prepared stock solution mixture for oral administration and external use for treating human metabolic syndrome and sterilizing and diminishing inflammation, which has the following curative effects:
the medicine is taken orally to treat the symptoms caused by human metabolic syndrome without side effect.
Oral administration: treating phlegm dampness obesity, insomnia, alopecia, edema, gastritis, diabetes, hypertension, hyperglycemia, hyperlipidemia, gout, tumor, numbness, vertigo, halitosis, constipation, etc. caused by metabolism syndrome disorder.
Secondly, the external use has the functions of sterilization, inflammation diminishing, sterilization, itching relieving and swelling diminishing, and has no harm to the skin of the human body.
External use: has antibacterial, antiinflammatory, antipruritic, and repercussive effects, and is suitable for treating corner ulcer, oral ulcer, toothache, acne, nasopharyngitis, pruritus, wound inflammation, paronychia, onychomycosis, tinea pedis, bromhidrosis, foot odor, and hemorrhoid.
The invention is further described.
In order to realize the above curative effect, the invention provides the following technical scheme:
example 1: a Chinese medicine oral and external use stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation is used as a further scheme of the invention: 230g of seaweed, 130g of dried orange peel, 400mg of cordyceps militaris, 120g of ampelopsis grossedentata tea, 120g of dendrobium, 110g of pummelo peel, 30g of red date, 120g of white poria, 10g of dried pawpaw seed, 8g of dried pineapple flower, 80g of hawthorn, 120g of astragalus root, 120g of dried liquorice, 90g of mulberry, 20g of black fungus, 60g of dried ginger, 20g of wormwood and 80g of green tea. Decocting the raw materials with water twice: adding 10 times of water for the first time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 8 times of water for the second time, boiling for 2 hr, decocting with slow fire for 4 hr, mixing decoctions, and filtering with 300-mesh 400-mesh filter screen to obtain the final product. Putting the filter screen decoction into a multifunctional traditional Chinese medicine extraction tank, extracting by adopting a steam distillation method, condensing, collecting a distillation stock solution, and filling to obtain the traditional Chinese medicine.
Example 2: a Chinese medicine oral and external use stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation is used as a further scheme of the invention: 240g of seaweed, 140g of dried orange peel, 300mg of cordyceps militaris, 110g of ampelopsis grossedentata tea, 110g of dendrobium, 120g of pummelo peel, 30g of red date, 130g of white poria, 9g of dried pawpaw seed, 6g of dried pineapple flower, 90g of hawthorn, 140g of astragalus root, 130g of dried liquorice, 80g of mulberry, 20g of black fungus, 60g of dried ginger, 10g of wormwood and 90g of green tea. Decocting the raw materials with water twice: adding 10 times of water for the first time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 8 times of water for the second time, boiling for 2 hr, decocting with slow fire for 4 hr, mixing decoctions, and filtering with 300-mesh 400-mesh filter screen to obtain the final product. Putting the filter screen decoction into a multifunctional traditional Chinese medicine extraction tank, extracting by adopting a steam distillation method, condensing, collecting a distillation stock solution, and filling to obtain the traditional Chinese medicine.
Example 3: a Chinese medicine oral and external use stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation is used as a further scheme of the invention: 260g of seaweed, 120g of dried orange peel, 200mg of cordyceps militaris, 90g of ampelopsis grossedentata tea, 80g of dendrobium, 110g of pummelo peel, 30g of red date, 150g of white poria, 6g of dried pawpaw seed, 5g of dried pineapple flower, 90g of hawthorn, 180g of astragalus, 160g of dried liquorice, 60g of mulberry, 20g of black fungus, 60g of dried ginger, 8g of wormwood and 120g of green tea. Decocting the raw materials with water for three times: adding 10 times of water for the first time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 8 times of water for the second time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 6 times of water for the third time, boiling for 2 hr, decocting with slow fire for 4 hr, mixing decoctions, and filtering with 300-400 mesh filter screen to obtain the final product. Putting the filter screen decoction into a multifunctional traditional Chinese medicine extraction tank, extracting by adopting a steam distillation method, condensing, collecting a distillation stock solution, and filling to obtain the traditional Chinese medicine.
Example 4: a Chinese medicine oral and external use stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation is used as a further scheme of the invention: 180g of seaweed, 160g of dried orange peel, 800mg of cordyceps militaris, 190g of ampelopsis grossedentata tea, 180g of dendrobium, 160g of pummelo peel, 30g of red date, 90g of white poria, 16g of dried pawpaw seed, 15g of dried pineapple flower, 60g of hawthorn, 90g of astragalus, 80g of dried liquorice, 80g of mulberry, 20g of black fungus, 60g of dried ginger, 30g of wormwood and 90g of green tea. Decocting the raw materials in water for four times: adding 10 times of water for the first time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 8 times of water for the second time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 6 times of water for the third time, boiling for 2 hr, and decocting with slow fire for 4 hr; adding 5 times of water for the fourth time, boiling for 1 hr, decocting with slow fire for 4 hr, mixing decoctions, and sieving with 300-mesh 400-mesh filter screen to obtain the final product. Putting the filter screen decoction into a multifunctional traditional Chinese medicine extraction tank, extracting by adopting a steam distillation method, putting Cordyceps militaris and herba Dendrobii powder bags (1 g of Cordyceps militaris and 200g of herba Dendrobii) while decocting, distilling, condensing, collecting distillation stock solution (2 times by distillation method), and filling.
Example 5: a Chinese medicine oral and external use stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation is used as a further scheme of the invention: 180g of seaweed, 180g of dried orange peel, 900mg of cordyceps militaris, 200g of ampelopsis grossedentata tea, 220g of dendrobium, 180g of pummelo peel, 30g of red date, 90g of white poria, 20g of dried pawpaw seed, 20g of dried pineapple flower, 60g of hawthorn, 90g of astragalus, 80g of dried liquorice, 10g of mulberry, 20g of black fungus, 60g of dried ginger, 40g of wormwood and 100g of green tea. Decocting the raw materials in water for four times: adding 10 times of water for the first time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 8 times of water for the second time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 6 times of water for the third time, boiling for 2 hr, and decocting with slow fire for 4 hr; adding 5 times of water for the fourth time, boiling for 1 hr, decocting with slow fire for 4 hr, mixing decoctions, and sieving with 300-mesh 400-mesh filter screen to obtain the final product. Putting the filter screen decoction into a multifunctional traditional Chinese medicine extraction tank, extracting by adopting a steam distillation method, putting Cordyceps militaris and herba Dendrobii powder bags (1.2 g of Cordyceps militaris and 240g of herba Dendrobii) simultaneously, decocting and distilling, condensing, collecting a distillation stock solution (2 times by using a distillation method), and filling to obtain the product.
In the aspect of oral administration:
a Chinese medicinal oral and external stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation, wherein the Chinese medicinal formula of the embodiment 4 is used as a final preferable scheme of the invention.
First, in order to explain the present invention in the aspect of internal administration: the treatment of symptoms caused by metabolic syndrome in human body is described in detail below.
As described in detail below, the invention "example 4" is applied to the internal medicine: the data and the curative effect of treating the symptoms caused by the metabolic syndrome of the human body.
"example 4" of the present invention is in terms of internal medicine: the data and the curative effect for treating the symptoms caused by the metabolic syndrome of the human body are detailed in the table 1.
The diagnosis standard of the metabolic syndrome is based on the diagnosis standard of diabetes mellitus subcontract (CSS) of Chinese medical society: the method comprises the following 3 items or more. 1. Overweight and/or obesity: BMI is more than or equal to 25kg/m 2; 2. blood lipid disorders: the fasting blood TG is more than or equal to 1.7mmol/L, and (or) the fasting blood HDL-C is less than 0.9mmol/L for men or less than 1.0mmol/L for women, (or) the dyslipidaemia is diagnosed; 3. hyperglycemia: FPG is more than or equal to 6.1mmol/L (110mg/dl) and/or 2hPG is more than or equal to 7.8mmol/L (140mg/dl), (or) a person diagnosed as a diabetes treatment; 4. hypertension: SBP/DBP is not less than 140/90mmHg, and/or has been diagnosed as hypertension.
Meets the diagnosis standard of metabolic syndrome, and is between 18 and 70 years old.
Case exclusion criteria: 1. patients under the age of 18 or over the age of 70 years; 2. patients with acute complications of diabetes (including diabetic hypoglycemia, diabetic hyperosmolar coma, diabetic ketoacidosis and ketoacidosis, diabetic lactic acidosis, and diabetic acute infection) in about 1 month; 3. patients with severe center of gravity, liver and renal insufficiency are merged; 4. failure to collaborate with psychotic disorders; 5. pregnant or lactating and pregnant woman preparation 6. who is not concerned (who can not be fasted or can not take traditional Chinese medicine according to the regulation to affect the curative effect); 7. patients with malignant tumor and hematopathy; 8. active tuberculosis patients; 9. ulcerated patients with severe gastrorrhagia; a patient with type I diabetes; type II diabetes mellitus is poorly controlled, in patients requiring insulin injections; 12. the oral antihypertensive drug for primary hypertension is used for poor control and secondary hypertension patients; 13. other cases considered unsuitable by researchers.
A Chinese medicinal composition (oral and topical Chinese medicinal composition) for treating metabolic syndrome, killing bacteria and relieving inflammation, and its application method comprises: the medicine is taken twice daily, and the daily dosage is 1 bottle (30 ml/bottle). When the first morning is empty, preparing half cup of about 80ml of boiled water with the water temperature of about 55-60 ℃, and pouring 15ml of the stock solution for drinking; the second time, half an hour after lunch (the administration method is the same as that of the first time).
Observation indexes are as follows: 1. the therapeutic effect indexes of weight, blood pressure, blood lipid and blood sugar change; 2. the safety indexes include hypoglycemia incidence rate, hunger degree, treatment compliance, liver and kidney functions and blood routine.
Body weight, metabolism, etc., and blood pressure lipid sugar changes are detailed in table 1.
Table 1.
A Chinese medicine in the form of oral liquid or liquid for treating the metabolic syndrome, sterilizing and relieving inflammation is disclosed, which is used to treat the symptoms caused by metabolic syndrome and evaluate the comprehensive curative effect.
The oral administration curative effect is as follows: after 20 patients with phlegm-dampness obesity are treated, the average reduction is about 6-8KG, wherein the fat is reduced by about 10%, the bone salt content is increased by about 1KG, the muscle content is increased by about 10KG, the basal metabolic rate is normal, and all 20 cases are effective cases.
The oral administration curative effect also comprises that in 40 cases of patients with blood pressure, blood fat and blood sugar, the first 40 cases are patients with hypertension, blood fat and blood sugar, after treatment, the blood pressure is well controlled, the total cholesterol reaches the triglyceride standard, and the high and low density lipoprotein cholesterol reaches the standard, and all 40 cases are effective cases.
And (3) safety evaluation: the B ultrasonic in 20 patients with phlegm-dampness and obesity suggests that 11 patients have fatty liver with different degrees, wherein 3 patients have an increased transaminase index in the early treatment stage (1 week after the treatment starts) and exceed the normal range, but have no clinical significance, the transaminase is reduced to below the original level at the end of the treatment, and the renal function index and the blood routine examination are not abnormal; among 40 diabetics, 5 patients have self complaints and are easy to have hypoglycemia reaction at ordinary times, but hypoglycemia does not occur in the whole treatment process, 4 patients with normal blood pressure have unobvious blood pressure fluctuation in the treatment process, and the change before and after treatment is not obviously different.
Conclusion of table 1: the medicine is orally taken to treat the symptoms caused by the human metabolic syndrome and has good treatment effect.
External use aspect:
a Chinese medicinal oral and external stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation, wherein the Chinese medicinal formula of the embodiment 4 is used as a final preferable scheme of the invention.
Secondly, in order to explain the invention, in the aspect of external application, the invention provides a method for treating relevant symptoms such as sterilization and anti-inflammation of mice, and the experimental data and effects of the invention are described in detail below.
The following examples are intended to further illustrate the present invention, but should not be construed as limitations or restrictions on the present invention, and unless otherwise specified, features used in the examples may be replaced by other features having equivalent functions or effects without departing from the inventive concept, and other features known in the art.
Examples 1-5 preliminary screening of stock solutions of herbal preparations, wherein "example" is a normally bred mouse. Experimental animals: the method is characterized in that healthy male Kunming mice of 30-35 days old are selected, 20 mice are used in each group, and each group is measured according to indexes of interleukin-2 (interleukin-2 kit Beijing Jingjinmei entity engineering Co., Ltd.), tumor necrosis factor-a (tumor necrosis factor-a kit Eboantibody (Shanghai) trade Co., Ltd.), gamma interferon (swelling gamma interferon kit Shanghai Zhen Shi Shuang Co., Ltd.), staphylococcus aureus, escherichia coli, salmonella gallinarum, proteus and salmonella murinus, so that the embodiment 4 of the invention can better diminish inflammation, kill or inhibit various bacteria.
In some embodiments, the dosage form is a herbal stock solution mixture.
Aiming at the matching of each group of traditional Chinese medicine stock solution mixture and each microorganism, two identical plate culture dishes are taken, and 1, before the anti-inflammatory drug experiment, the anti-inflammatory drug promotes the body to recover health: culturing strain of mouse injury with liquid LB to multiply amplify recipient strain, taking 20 mice each, and inoculating 0.1mL (about 5 million virus particle bacteria) subcutaneously for each mouse; 2. before the experiment of the bactericidal medicine, the function is to kill the corresponding pathogenic microorganisms in the animal body: solid LB culture rat wound strains, implanted about per ml containing ten eight times of bacteria. The control group is a common solid LB culture medium, 1ml of the stock solution of the traditional Chinese medicine composition is added into the molten LB culture used by the test group, and the solid LB culture medium is formed after uniform mixing and cooling. To this group of LB medium plates, 0.1mL of bacteria each having a concentration of about 5 million virus particles (7 th power/mL of 10) was added dropwise and cultured under the same condition F37C for 24 hours. Calculating the number of colonies in the LB plate without the traditional Chinese medicine composition as Nc, the number of colonies in the LB plate with the traditional Chinese medicine composition as Nt, the bacteriostasis rate as n, and wiping the wound of the mouse if n ═ Nc-Nt/Nc ] X100%.
The traditional Chinese medicine stock solution mixture composition provided by the invention can inhibit the application of interleukin-2, tumor necrosis factor-a and gamma interferon in medicines for treating, preventing or improving diseases caused by bacteria.
The traditional Chinese medicine stock solution mixture composition provided by the invention is used in medicines for treating, preventing or improving diseases caused by staphylococcus aureus, escherichia coli, salmonella gallinarum, proteus and salmonella murinus.
The traditional Chinese medicines of the invention are used for preparing a stock solution mixture composition. 1. In the aspect of anti-inflammation, the concentration of interleukin-2, tumor necrosis factor-a and gamma interferon in a mouse body can be effectively inhibited, and various bacteria can be killed or inhibited; 2. in the aspect of inhibiting or killing bacteria, at least five bacteria can be effectively inhibited or killed against staphylococcus aureus, escherichia coli, salmonella gallinarum, proteus vulgaris and salmonella murinus.
The relevant test data are detailed in table 2.
Table 2.
Conclusion of table 2: a Chinese medicinal oral and external stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation, which is used for evaluating the treatment effect of a mouse sterilization experiment: the composition can effectively inhibit the concentrations of IL-2, TNF-a and IFN-Y in mice and kill or inhibit various bacteria, so that the composition can be used as a traditional Chinese medicine composition with sterilization and anti-inflammation effects.
A Chinese medicinal oral administration and external use stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation, the Chinese medicinal stock solution mixture has definite curative effect, is taken orally, and has no toxic or side effect; it is applied externally and has no damage to skin.
1. The oral administration can treat the symptoms caused by human metabolic syndrome without side effect.
Oral administration: treating phlegm dampness obesity, insomnia, alopecia, edema, gastritis, diabetes, hypertension, hyperglycemia, hyperlipidemia, gout, tumor, numbness, vertigo, halitosis, constipation, etc. caused by metabolism syndrome disorder.
2. The external use has the functions of sterilization, inflammation diminishing, sterilization, itching relieving and swelling diminishing, and has no harm to the skin of a human body.
External use: has antibacterial, antiinflammatory, antipruritic, and repercussive effects, and is suitable for treating corner ulcer, oral ulcer, toothache, acne, nasopharyngitis, pruritus, wound inflammation, paronychia, onychomycosis, tinea pedis, bromhidrosis, foot odor, and hemorrhoid.
The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention are intended to be included in the scope of the present invention.
Claims (7)
1. The invention relates to a traditional Chinese medicine prepared stock solution mixture for oral administration and external use for treating human metabolic syndrome and sterilizing and diminishing inflammation, which has the following curative effects: the traditional Chinese medicine raw liquid mixture has definite curative effect, is taken orally and has no toxic or side effect; it is applied externally and has no damage to skin.
2. The parts are mass parts, and are microgram, milligram, gram, kilogram and other mass units commonly used in the field.
3. A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation is provided. The technical scheme of the formula adopted by the invention is as follows: the tea is prepared from the following raw materials of dried pineapple flowers, dried pawpaw seeds, mulberry, black fungus, seaweed, astragalus mongholicus, dried liquorice, white poria, dried orange peel, cordyceps militaris, pummelo peel, red dates, hawthorn, dried ginger, maoyanmei tea, wormwood, green tea and dendrobium by mass: 320 parts of seaweed 180-.
4. A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation is provided. The preferable formula is synthesized, and specifically: 180g of seaweed, 160g of dried orange peel, 800mg of cordyceps militaris, 190g of ampelopsis grossedentata tea, 180g of dendrobium, 160g of pummelo peel, 30g of red date, 90g of white poria, 16g of dried pawpaw seed, 15g of dried pineapple flower, 60g of hawthorn, 90g of astragalus, 80g of dried liquorice, 80g of mulberry, 20g of black fungus, 60g of dried ginger, 30g of wormwood and 90g of green tea.
5. A Chinese medicinal oral and topical stock solution mixture for treating human metabolic syndrome and resisting bacteria and inflammation is prepared by: decocting the raw materials in water for four times: adding 10 times of water for the first time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 8 times of water for the second time, boiling for 2 hours, and decocting with slow fire for 4 hours; adding 6 times of water for the third time, boiling for 2 hr, and decocting with slow fire for 4 hr; adding 5 times of water for the fourth time, boiling for 1 hr, decocting with slow fire for 4 hr, mixing decoctions, and sieving with 300-mesh 400-mesh filter screen to obtain the final product. Putting the filter screen decoction into a multifunctional traditional Chinese medicine extraction tank, extracting by adopting a steam distillation method, putting Cordyceps militaris and herba Dendrobii powder bags (1 g of Cordyceps militaris and 200g of herba Dendrobii) while decocting, distilling, condensing, collecting distillation stock solution (2 times by distillation method), and filling.
6. The invention relates to a traditional Chinese medicine oral and external stock solution mixture for treating human metabolic syndrome and sterilizing and diminishing inflammation, which has the following oral and external curative effects:
1. the oral administration can treat the symptoms caused by human metabolic syndrome without side effect. Oral administration: treating phlegm dampness obesity, insomnia, alopecia, edema, gastritis, diabetes, hypertension, hyperglycemia, hyperlipidemia, gout, tumor, numbness, vertigo, halitosis, constipation, etc. caused by metabolism syndrome disorder.
2. The external use has the functions of sterilization, inflammation diminishing, sterilization, itching relieving and swelling diminishing, and has no harm to the skin of a human body.
External use: has antibacterial, antiinflammatory, antipruritic, and repercussive effects, and is suitable for treating corner ulcer, oral ulcer, toothache, acne, nasopharyngitis, pruritus, wound inflammation, paronychia, onychomycosis, tinea pedis, bromhidrosis, foot odor, and hemorrhoid.
7. A Chinese medicinal oral and topical stock solution mixture for treating human metabolic syndrome and resisting bacteria and inflammation, its application method comprises: 1. the oral administration is carried out, the daily dose is 30ml, the oral administration is carried out for 2 times, specifically 15ml (1/3 cups of about 80ml boiled water with water temperature of 50-60 ℃) is taken once in each morning on an empty stomach and half an hour after lunch, the oral administration has the curative effect, 20 days is a course of treatment, the effect is usually achieved within one week, and the cure can be realized in one to two courses of treatment; 2. the external application can be applied for multiple times according to actual requirements, has the effects of sterilizing and diminishing inflammation, relieving itching and reducing swelling for external application, and can be cured within one day and three to five days.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910528945.3A CN112076305A (en) | 2019-06-12 | 2019-06-12 | A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201910528945.3A CN112076305A (en) | 2019-06-12 | 2019-06-12 | A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112076305A true CN112076305A (en) | 2020-12-15 |
Family
ID=73734252
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201910528945.3A Withdrawn CN112076305A (en) | 2019-06-12 | 2019-06-12 | A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN112076305A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114698845A (en) * | 2022-04-11 | 2022-07-05 | 湖北工业大学 | Application of Poria cocos polysaccharide EGC composition in inhibiting the formation of arginine in the gastrointestinal tract |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1185955A (en) * | 1996-12-23 | 1998-07-01 | 李来明 | Chinese medicine tea for constipation |
CN102422947A (en) * | 2011-11-05 | 2012-04-25 | 安徽省天旭茶业有限公司 | Multi-component lotus leaf tea beverage and preparation method thereof |
CN107125382A (en) * | 2017-04-19 | 2017-09-05 | 王祖纲 | A kind of invigorating heart health preserving tea and preparation method thereof |
-
2019
- 2019-06-12 CN CN201910528945.3A patent/CN112076305A/en not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1185955A (en) * | 1996-12-23 | 1998-07-01 | 李来明 | Chinese medicine tea for constipation |
CN102422947A (en) * | 2011-11-05 | 2012-04-25 | 安徽省天旭茶业有限公司 | Multi-component lotus leaf tea beverage and preparation method thereof |
CN107125382A (en) * | 2017-04-19 | 2017-09-05 | 王祖纲 | A kind of invigorating heart health preserving tea and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
黄春林 等主编: "《心肾疾病临证证治》", 31 March 2000, 广东人民出版社 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114698845A (en) * | 2022-04-11 | 2022-07-05 | 湖北工业大学 | Application of Poria cocos polysaccharide EGC composition in inhibiting the formation of arginine in the gastrointestinal tract |
CN114698845B (en) * | 2022-04-11 | 2023-08-18 | 湖北工业大学 | Application of pachyman EGC composition in inhibiting formation of gastrointestinal argininyl |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103652361B (en) | Feed for postpartum sow in lactation period of 1-20 days and preparation method thereof | |
CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
CN103690919B (en) | Medicine being used for the treatment of piglet iron-deficiency anemia and preparation method thereof | |
CN105233100A (en) | Drink for treating diabetes and preparation method thereof | |
CN104815192A (en) | Pharmaceutical composition for treating hypertension and application of pharmaceutical composition | |
CN102552779A (en) | Health-care traditional Chinese medicine composition with effect of human body blood purification and health-care product thereof | |
CN112076305A (en) | A Chinese medicinal oral and topical stock solution mixture for treating metabolic syndrome and resisting bacteria and inflammation | |
CN1142785C (en) | Antifatigue capsule | |
CN109528966A (en) | A kind of health liquor and preparation method thereof | |
CN102988747B (en) | Aristida triseta electuary for reducing hypertension, hyperglycemia and hyperlipidemia and preparation method thereof | |
CN104398969A (en) | Post-renal transplantation treating and health care traditional Chinese medicine | |
CN107890521A (en) | A kind of Chinese medicine composition of liver protection and eyesight and its preparation method of pill | |
CN103340991B (en) | Oral liquid for nursing diabetics and preparation method thereof | |
CN106822660A (en) | A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease | |
CN114748583A (en) | Traditional Chinese medicine liquor for nourishing and preserving health | |
CN112294925A (en) | A medicine for treating gout, gastropathy and constipation, and its preparation method | |
CN111084878A (en) | Biological medicine and medical total nutrient food for lung and respiratory system diseases and preparation method thereof | |
CN104940710A (en) | Traditional Chinese medicine Kangning composition comprising soncretio silicea bambusae for treating epilepsy, and preparation method thereof | |
CN108524861A (en) | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating insomnia | |
CN109289017A (en) | For clearing up the composition and preparation method of blood vessel and blood | |
KR100712659B1 (en) | Herbal composition for the treatment and prevention of diabetes and its complications | |
CN109771567A (en) | A kind of formula of Chinese herbal medicine supporting vital QI and dispersing blood stasis toxin expelling tumour | |
CN107137689A (en) | A kind of Chinese medicine composition for treating menopausal syndrome | |
CN103933368B (en) | Be used for the treatment of pharmaceutical composition of puerperal constipation and preparation method thereof | |
CN107029151A (en) | Medicine for treating type of deficiency of both the heart and spleen insomnia |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20201215 |
|
WW01 | Invention patent application withdrawn after publication |