CN111821219A - Composition with moisturizing effect and application thereof - Google Patents
Composition with moisturizing effect and application thereof Download PDFInfo
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- CN111821219A CN111821219A CN202010825388.4A CN202010825388A CN111821219A CN 111821219 A CN111821219 A CN 111821219A CN 202010825388 A CN202010825388 A CN 202010825388A CN 111821219 A CN111821219 A CN 111821219A
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- moisturizing
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- polyglycerol
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- 230000003020 moisturizing effect Effects 0.000 title claims abstract description 124
- 239000000203 mixture Substances 0.000 title claims abstract description 62
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 36
- 235000005152 nicotinamide Nutrition 0.000 claims abstract description 18
- 239000011570 nicotinamide Substances 0.000 claims abstract description 18
- 229960003966 nicotinamide Drugs 0.000 claims abstract description 18
- UOQHWNPVNXSDDO-UHFFFAOYSA-N 3-bromoimidazo[1,2-a]pyridine-6-carbonitrile Chemical compound C1=CC(C#N)=CN2C(Br)=CN=C21 UOQHWNPVNXSDDO-UHFFFAOYSA-N 0.000 claims abstract description 17
- 229940099563 lactobionic acid Drugs 0.000 claims abstract description 17
- 229920000223 polyglycerol Polymers 0.000 claims abstract description 17
- 239000000839 emulsion Substances 0.000 claims description 44
- 238000002156 mixing Methods 0.000 claims description 32
- 238000003756 stirring Methods 0.000 claims description 27
- 239000011259 mixed solution Substances 0.000 claims description 20
- 239000003921 oil Substances 0.000 claims description 19
- 238000002360 preparation method Methods 0.000 claims description 13
- 239000003995 emulsifying agent Substances 0.000 claims description 12
- 239000002562 thickening agent Substances 0.000 claims description 12
- 239000003755 preservative agent Substances 0.000 claims description 10
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- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical group OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 3
- 125000003118 aryl group Chemical group 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000004359 castor oil Substances 0.000 claims description 3
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- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 235000010446 mineral oil Nutrition 0.000 claims description 3
- 239000003002 pH adjusting agent Substances 0.000 claims description 3
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 2
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 2
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 claims description 2
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 2
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- 210000003491 skin Anatomy 0.000 abstract description 45
- 230000002195 synergetic effect Effects 0.000 abstract description 7
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 14
- 230000000694 effects Effects 0.000 description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 7
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- 229940010747 sodium hyaluronate Drugs 0.000 description 3
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 3
- 150000005846 sugar alcohols Polymers 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 102100028314 Filaggrin Human genes 0.000 description 2
- 101710088660 Filaggrin Proteins 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
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- 239000006210 lotion Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- BEGLCMHJXHIJLR-UHFFFAOYSA-N methylisothiazolinone Chemical compound CN1SC=CC1=O BEGLCMHJXHIJLR-UHFFFAOYSA-N 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229940064064 purslane extract Drugs 0.000 description 2
- 230000037394 skin elasticity Effects 0.000 description 2
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- 238000005728 strengthening Methods 0.000 description 2
- CCLARULDIPFTCP-BOYHRMMASA-N (2r,3r,4r,5s)-heptane-1,2,3,4,5,6-hexol Chemical compound CC(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CCLARULDIPFTCP-BOYHRMMASA-N 0.000 description 1
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- 229940015975 1,2-hexanediol Drugs 0.000 description 1
- IHCCLXNEEPMSIO-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperidin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 IHCCLXNEEPMSIO-UHFFFAOYSA-N 0.000 description 1
- LLQHSBBZNDXTIV-UHFFFAOYSA-N 6-[5-[[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]methyl]-4,5-dihydro-1,2-oxazol-3-yl]-3H-1,3-benzoxazol-2-one Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC1CC(=NO1)C1=CC2=C(NC(O2)=O)C=C1 LLQHSBBZNDXTIV-UHFFFAOYSA-N 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- 240000006497 Dianthus caryophyllus Species 0.000 description 1
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- 241000196324 Embryophyta Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000037534 Progressive hemifacial atrophy Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
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- 150000001413 amino acids Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
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- 238000000576 coating method Methods 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- 150000002772 monosaccharides Chemical class 0.000 description 1
- 238000012017 passive hemagglutination assay Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
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- 230000017423 tissue regeneration Effects 0.000 description 1
- 238000012795 verification Methods 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a composition with moisturizing effect and application thereof. The composition with moisturizing effect comprises polyglycerol, lactobionic acid and nicotinamide. The composition with the moisturizing effect has the advantages that the three components are matched with each other, the composition has a synergistic effect, and the instant moisturizing effect and the long-acting moisturizing effect are very obvious, so that the water locking and moisturizing effects of the skin can be improved for a long time, the long-term water retention of the stratum corneum is achieved, the molting phenomenon is improved, and the barrier function is enhanced.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and relates to a composition with a moisturizing effect and application thereof.
Background
With the improvement of the living standard of people, the pursuit of health and beauty leads the requirements of consumers on moisturizing products, especially moisturizing milk to be not limited to instant moisturizing, but have higher requirements, and the effects of instant moisturizing and long-acting moisturizing are considered, so that the skin moisturizing cream is safe and low in stimulation experience, good and comfortable in use skin feel, and high in cost performance suitable for mass skin care. However, most moisturizing emulsions currently on the market still do not meet the above-mentioned consumer's higher requirements.
The common moisturizing emulsion on the market is mainly divided into the following components according to a formula system and selected moisturizing agents: 1. polyhydric alcohol humectant: the molecular structure of the water-retaining agent contains polyhydroxy, so that the water-retaining agent can adsorb water molecules to play a role in moisture retention, and has a good instant effect, but the water-retaining agent has the defect of weak long-acting moisture retention capacity; 2. polysaccharide humectant: the principle is that the macromolecular polysaccharide forms a layer of macromolecular membrane on the surface of the skin to delay the evaporation of water and play a role in moisturizing, the moisturizing agent has the instant and long-acting moisturizing effect, and the defects are that the macromolecular membrane generates sticky feeling on the skin and the use experience is low; 3. amino acid humectant: this type of moisturizer has good skin friendliness and low irritation, but its price is often expensive, increasing the formulation cost.
CN108420757A discloses moisturizing water and a preparation process thereof, wherein the moisturizing water comprises the following components in parts by weight: 0.1-0.2 part of sodium hyaluronate; 4-5 parts of an alcohol humectant; 2.8-3.5 parts of a first compound humectant; 2.5-3.8 parts of a second compound humectant; 2-3.5 parts of methyl glucitol polyether-20; 10-12 parts of a skin conditioner; 73.62-75.7 parts of pure water; the alcohol humectant comprises at least one of 1, 3-butanediol and 1, 2-hexanediol; the first compound humectant consists of pure water, polyglucuronic acid, mannose, beta-glucan and lactobionic acid; the second compound humectant is a mixture of glycerin and glycerin polyacrylate. The humectant achieves a certain moisturizing effect by adding various polyhydric alcohol humectants and polysaccharide humectants, but has the defects of weak long-acting moisturizing capability, easy generation of sticky feeling on skin and low use experience.
CN110279628A discloses a cosmetic composition for relieving and moisturizing and a preparation thereof. The cosmetic composition for relieving and moisturizing comprises 1-5 parts of purslane extract; 1-10 parts of nicotinamide; and 1-5 parts of water-locking magnet. The purslane extract, the nicotinamide and the lodestone are compounded according to a limited proportion, so that the obtained composition and the cosmetic preparation have good effects of relieving and moisturizing, but have the defect of weak long-acting moisturizing capability.
Therefore, the development of a skin care product having the effect of continuously replenishing water and moisturizing is the focus of research in the field.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a composition with moisturizing effect and application thereof. The composition with the moisturizing effect has the synergistic effect due to the mutual cooperation of the three components, so that the effects of deep moisturizing and lasting moisturizing are achieved.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the present invention provides a composition with moisturising effect, comprising polyglycerol, lactobionic acid and nicotinamide.
According to the composition with the moisturizing effect, the three components of the polyglycerol, the lactobionic acid and the nicotinamide are matched with each other, so that the composition has a synergistic effect, can maintain the nutritional balance of skin, and directly reach the skin water-deficient dry part, and is helpful for promoting the absorption effect of the skin, improving the water locking and moisturizing effects of the skin, increasing the water retention of stratum corneum, improving the molting phenomenon and strengthening the barrier function, thereby improving the dry skin and increasing the skin elasticity.
Wherein, the polyglycerol is produced by glycerol from plant sources, is polyhydric alcohol which generates ether bonds after the hydroxyl groups between two or more glycerol molecules are dehydrated, and the film formed on the skin is a three-dimensional and air-permeable structure and has the characteristic of oil-water commonality, and can be continuously formed into a film on the skin; meanwhile, the skin care product is also of a multi-branched structure, has certain oil control property, and does not generate sticky feeling on the skin like other oil ester or polysaccharide moisturizers. Lactobionic acid belongs to the third generation of fruit acids, which consists of a monosaccharide and PHAs, and has some advantages of both sugar and acid. The molecular structure of the water-based moisture-preserving agent has eight hydroxyl hydrophilic groups, so that the water-based moisture-preserving agent has a strong moisture-preserving effect; and the lactobionic acid has excellent water-retaining property, inhibits hydroxyl in the structure, can play a role in preventing skin aging, promotes epidermal tissue regeneration, and combines collagen to achieve the effect of repairing damaged skin. Nicotinamide (vitamin B3) is a very common and stable vitamin, and Nicotinamide can increase the level of normal filaggrin, and filaggrin is the precursor of NMF (natural moisturizing factor), so Nicotinamide can increase the skin moisture and reduce the loss of moisture through the skin.
Preferably, the mass ratio of the polyglycerol, the lactobionic acid and the nicotinamide is (2-4): (1-2);
wherein the first "2-4" can be 2, 2.5, 3, 3.5, 4, etc.;
wherein the second "2-4" can be 2, 2.5, 3, 3.5, 4, etc.;
wherein, 1-2 can be 1, 1.2, 1.4, 1.6, 1.8, 2, etc.
Preferably, the mass ratio of the polyglycerol, lactobionic acid and nicotinamide is 3:3: 1.
Preferably, the polyglycerol comprises any one of or a combination of at least two of polyglycerol-2, polyglycerol-4, polyglycerol-6, polyglycerol-8 or polyglycerol-10, preferably polyglycerol-6.
The polyglycerol in the invention is preferably polyglycerol-6, the average molecular weight is about 462, the polyglycerol has skin affinity and skin penetration reducing capability, the synergistic effect of the polyglycerol and lactobionic acid and nicotinamide is more excellent, and the polyglycerol can play better and longer moisturizing and moistening effects on skin
In a second aspect, the present invention provides a use of the composition having moisturizing effect according to the first aspect in the preparation of cosmetics.
Preferably, the amount of the composition having moisturizing effect added is 5-20% of the mass of the cosmetic, and may be, for example, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, etc.
In a third aspect, the invention provides a moisturizing emulsion, which comprises the following components in percentage by mass: the composition with the moisturizing effect comprises, by weight, 5-20% of a moisturizing composition, 0.5-2% of an emulsifier, 1-5% of grease, 0.05-0.5% of a thickening agent, and the balance water.
The amount of the composition having moisturizing effect according to the first aspect is 5 to 20%, for example, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, etc., based on 100% by mass of the moisturizing emulsion.
The amount of the emulsifier added is 0.5 to 2%, for example, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.2%, 1.4%, 1.6%, 1.8%, 2%, etc., based on 100% by mass of the moisturizing emulsion.
The amount of the oil or fat added is 1 to 5% by mass of the moisturizing emulsion, and may be, for example, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, or the like.
The amount of the thickener added is 0.05 to 0.5%, for example, 0.05%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5% or the like, based on 100% by mass of the moisturizing emulsion.
Preferably, the emulsifier is polyglyceryl-3 methyl glucose distearate.
Preferably, the grease is mineral oil.
Preferably, the thickener is a carbomer.
Preferably, the moisturizing emulsion further comprises a pH adjuster 0.1-0.3%, such as 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, and the like.
Preferably, the pH adjusting agent is triethanolamine.
Preferably, the moisturizing emulsion further comprises a preservative 0.1-1%, such as may be 0.1%, 0.2%, 0.4%, 0.6%, 0.8%, 1%, etc.
Preferably, the preservative comprises any one or a combination of at least two of methylparaben, ethylparaben or phenoxyethanol.
Preferably, the moisturizing emulsion further comprises a solubilizer 0.01-0.05%, such as 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, and the like.
Preferably, the solubilizer is PEG-40 hydrogenated castor oil.
Preferably, the moisturizing emulsion further comprises a fragrance 0.01-0.05%, such as 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, and the like.
Preferably, the fragrance is a perfume.
In a fourth aspect, the present invention provides a method for preparing the moisturizing emulsion according to the third aspect, the method comprising the steps of:
(1) mixing and stirring an emulsifier and grease to obtain an oil phase mixed solution; mixing and stirring a thickening agent and water to obtain a water-phase mixed solution;
(2) mixing the oil phase mixed solution and the water phase mixed solution obtained in the step (1), and shearing at a high speed to obtain a pre-emulsion;
(3) and (3) mixing and stirring the pre-emulsion obtained in the step (2) and the rest components to obtain the moisturizing emulsion.
Preferably, the temperature for mixing and stirring the emulsifier and the oil in the step (1) is 60-90 ℃, for example, 60 ℃, 65 ℃, 70 ℃, 75 ℃, 80 ℃, 85 ℃, 90 ℃ and the like, and the time for mixing and stirring is 10-30min, for example, 10min, 15min, 20min, 25min, 30min and the like.
Preferably, the temperature for mixing and stirring the composition with moisturizing effect, the thickener and the water in the step (1) is 70-90 ℃, for example, 70 ℃, 75 ℃, 80 ℃, 85 ℃, 90 ℃ and the like, and the time for mixing and stirring is 10-30min, for example, 10min, 15min, 20min, 25min, 30min and the like.
Preferably, the rotation speed of the high speed shearing in the step (2) is 10000-20000rpm, such as 10000rpm, 12000rpm, 15000rpm, 18000rpm, 20000rpm, etc., and the time of the high speed shearing is 3-5min, such as 3min, 3.5min, 4min, 4.5min, 5min, etc.
Preferably, the temperature of the mixing and stirring in the step (3) is 45 ℃ or less, for example, 45 ℃, 44 ℃, 43 ℃, 42 ℃, 41 ℃, 40 ℃, 39 ℃, 38 ℃, 37 ℃, 36 ℃, 35 ℃ and the like, and the time of the mixing and stirring is 10-20min, for example, 10min, 12min, 14min, 16min, 18min, 20min and the like.
Preferably, the preparation method of the moisturizing emulsion comprises the following steps:
(1) mixing emulsifier and oil at 60-90 deg.C, stirring for 10-30min to obtain oil phase mixed solution; mixing thickener and water at 70-90 deg.C, stirring for 10-30min to obtain water phase mixed solution;
(2) mixing the oil phase mixed solution and the water phase mixed solution obtained in the step (1), and shearing at a high speed of 10000-;
(3) mixing and stirring the pre-emulsion obtained in the step (2), the composition with moisturizing effect, a pH regulator, a preservative, a solubilizer and an aromatic at the temperature of below 45 ℃ for 10-20min to obtain the moisturizing emulsion.
Compared with the prior art, the invention has the following beneficial effects:
(1) the three components of the polyglycerol, the lactobionic acid and the nicotinamide in the composition with the moisturizing effect are matched with each other, so that the composition has a synergistic effect, can maintain the nutritional balance of skin, directly reaches the skin water-deficient dry part, is helpful for promoting the absorption effect of the skin, improving the water locking and moisturizing effects of the skin, increasing the water retention of the horny layer, improving the molting phenomenon and strengthening the barrier function, and is further helpful for improving the dry skin and increasing the skin elasticity;
(2) the moisturizing rate of the moisturizing emulsion prepared by adding the composition with moisturizing effect for 4 hours is more than 90%; the moisture content of the skin of the moisturizing emulsion prepared by adding the composition with the moisturizing effect is increased to more than 90% after 1 hour, the moisture content of the skin is increased to more than 92% after 3 hours, the moisture content of the skin is slightly reduced and still maintained at more than 90% after 8 hours, and the moisture content of the skin can still be maintained at more than 90% after 24 hours.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
The sources of the components in the following examples and comparative examples are as follows: polyglycerol-6 was purchased from (manufacturer: Longsha, brand: NATRUTON H-6), polyglycerol-2 was purchased from (manufacturer: Saka drug, brand: Diglycerin 801), polyglycerol-10 was purchased from (manufacturer: Longsha, brand: NATRUTON H-10), lactobionic acid was purchased from (manufacturer: Suzhou Nakang), nicotinamide was purchased from (manufacturer: Longsha, brand: Niacinamide USP PC).
The sources of the components in the following application examples and comparative application examples are as follows: polyglycerol-3 methyl glucose distearate was purchased from (manufacturer: winning, brand:
care 450), mineral oil purchased from (manufacturer: sonneborn, brand: carnation), carbomer from (manufacturer: 3V, brand number: polygel CA), triethanolamine were purchased from (manufacturer: dow), preservatives were purchased from (manufacturer: dow, brand: NEOLONE (TM) PH 100Preservative), PEG-40 hydrogenated castor oil from (manufacturer: basf, brand number: eumulgin C040).
Examples 1 to 6
The present example provides different compositions having moisturizing effect, and the formulations of the compositions having moisturizing effect provided in each example are shown in the following table 1:
TABLE 1
| Components | Polyglycerol-6 | Lactobionic acid | Nicotinamide |
| Practice ofExample 1 | 6 portions of | 6 portions of | 2 portions of |
| Example 2 | 7 portions of | 4 portions of | 3 portions of |
| Example 3 | 5 portions of | 7 portions of | 2 portions of |
| Example 4 | 3 portions of | 6 portions of | 5 portions of |
| Example 5 | 6 portions of | 3 portions of | 5 portions of |
| Example 6 | 7 portions of | 6 portions of | 1 part of |
Example 7
This example provides a composition having moisturizing effect, which is different from example 1 only in that polyglycerol-6 is replaced with polyglycerol-2, and the content of the components is the same as that of example 1.
Example 8
This example provides a composition having moisturizing effect, which is different from example 1 only in that polyglycerol-6 is replaced with polyglycerol-10, and the content of the components is the same as that of example 1.
Comparative examples 1 to 3
The present comparative example provides different compositions having moisturizing effect, and the formulations of the compositions having moisturizing effect provided in respective comparative examples are shown in the following table 2:
TABLE 2
| Components | Polyglycerol-6 | Lactobionic acid | Nicotinamide |
| Comparative example 1 | 0 portion of | 9 portions of | 5 portions of |
| Comparative example 2 | 9 portions of | 0 portion of | 5 portions of |
| Comparative example 3 | 7 portions of | 7 portions of | 0 portion of |
Application example 1
The application embodiment provides a moisturizing emulsion which comprises the following components in percentage by mass:
the preparation method of the moisturizing emulsion comprises the following steps:
(1) mixing emulsifier and oil at 80 deg.C, stirring for 20min to obtain oil phase mixed solution; mixing thickener and water at 80 deg.C, stirring for 20min to obtain water phase mixed solution;
(2) mixing the oil phase mixed solution and the water phase mixed solution obtained in the step (1), and shearing at a high speed of 150000rpm for 4min to obtain a pre-emulsion;
(3) mixing and stirring the pre-emulsion obtained in the step (2), the composition with moisturizing effect, the pH regulator, the preservative, the solubilizer and the aromatic at 40 ℃ for 10min to obtain the moisturizing emulsion.
Application examples 2 to 8
Compared with application example 1, the composition with moisturizing effect provided in example 1 is respectively and correspondingly replaced by the compositions with moisturizing effect provided in examples 2 to 8, and the content of other components and the preparation method are the same as application example 1.
Application of comparative examples 1 to 3
Compared with the application example 1, the compositions with moisturizing efficacy prepared in the example 1 are respectively and correspondingly replaced by the compositions with moisturizing efficacy provided in the comparative examples 1 to 3, and the contents of other components and the preparation method are the same as the application example 1.
Application comparative example 4
Compared with the application example 1, the composition with moisturizing effect prepared in the example 1 is replaced by glycerin, and the content of other components and the preparation method are the same as the application example 1.
Comparative application example 5
Compared with the application example 1, the composition with moisturizing effect prepared in the example 1 is replaced by propylene glycol, and the content of other components and the preparation method are the same as those of the application example 1.
Comparative application example 6
Compared with the application example 1, the composition with moisturizing effect prepared in the example 1 is replaced by sodium hyaluronate, and the content of other components and the preparation method are the same as those of the application example 1.
Application comparative example 7
Compared with the application example 1, the composition with moisturizing effect prepared in the example 1 is replaced by betaine, and the content of other components and the preparation method are the same as the application example 1.
Test example 1
Irritation testing machine evaluation method (skin seal patch test)
The test method comprises the following steps: 1. the subject was enrolled with selection criteria to participate in 30 panelists. 2. The test samples were loaded into the plaque tester chambers, and one group was selected as a blank control, and the plaque tester was taped to the forearm flexor of the subject for 24 h. 3. Skin reactions were observed 48h after removal of the test article patch, respectively, with skin-closed patch test skin reaction grading standards as shown in table 3, and specific test results as shown in table 4:
TABLE 3
TABLE 4
As can be seen from the test results in Table 4, in the skin sealing patch test, after 48 hours of the moisturizing lotion prepared by adding the composition with moisturizing efficacy, the subjects did not show any reaction and no adverse reaction, such as erythema, burning sensation or pruritus. The enclosed patch test shows that the composition with moisturizing effect has no irritation to skin. After pasting the moisturizing emulsions provided by the comparative example 4 (glycerin humectant), the comparative example 5 (propylene glycol humectant), the comparative example 6 (sodium hyaluronate humectant) and the comparative example 7 (betaine humectant) for 48 hours, suspicious reactions and erythema are occasionally occurred in the subjects, and the patients are particularly serious in the propylene glycol group.
Test example 2
In vitro weighing method for measuring moisture retention
The moisturizing emulsions provided in application examples 1 to 8 and the moisturizing emulsions provided in application comparative examples 1 to 7 were subjected to in vitro weighing method moisturizing performance measurement by the following method: weighing 0.2g of sample to be measured, respectively and uniformly coating the sample to be measured on a 5cm multiplied by 5cm glass plate stuck with the microporous ventilating adhesive tape, putting the glass plate into a dryer with constant temperature and constant humidity, respectively weighing the mass of the glass plate after being placed for 4 hours, and calculating the moisture retention rate. The moisture retention rate calculation formula is as follows:
moisture retention rate/% (M)2-M0)/(M1-M0)×100％。
Wherein M is0Is the mass/g, M, of the glass sheet1For the mass/g, M of the glass plate after sample application2The glass plate mass/g after being placed in the dryer for several hours.
The specific test results are shown in table 5:
TABLE 5
The test data in table 5 show that the moisturizing rate of the moisturizing emulsion prepared by adding the composition with moisturizing effect for 4 hours is above 90%, which indicates that the composition with moisturizing effect contains three components, namely polyglycerol, lactobionic acid and nicotinamide, which are matched with each other, has a synergistic effect, and can permanently improve the water locking and moisturizing effects of the skin, so that the excessive keratinization effect of the skin is avoided, the moisturizing degree of the skin is improved, and the skin can be kept moist after the composition is used.
Test example 3
Moisture retention efficacy test and verification
(1) The test scheme is as follows: evaluating the moisturizing function of each group of moisturizing emulsion products by detecting the water content of the skin on the inner side of the arm; the test instrument includes: skin moisture tester (MPA4), cosmetic cotton, 2mL syringe; the test samples included: examples 1 to 8 and application comparative examples 1 to 7;
(2) volunteer recruitment: the recruiter 12 people, age 18-50 years; the skin of the arm is healthy and has no damage, no allergy history and no disease history;
(3) data statistics and analysis: detecting the water content of the skin on the inner side of the arm before, after 1h, after 3h, after 8h and after 24h respectively;
the specific test results are shown in table 6:
TABLE 6
As can be seen from the test data in table 6, the moisture content of the skin of the moisturizing lotion prepared by adding the composition with moisturizing effect of the present invention increases to more than 90% after 1 hour, increases to more than 92% after 3 hours, slightly decreases but maintains more than 90% after 8 hours, and maintains more than 90% after 24 hours. The composition with the moisturizing effect shows that the three components of the polyglycerol, the lactobionic acid and the nicotinamide are matched with each other, so that the composition has a synergistic effect, and both the instant moisturizing effect and the long-acting moisturizing effect are very obvious, so that the water locking and moisturizing effects of skin can be improved for a long time, the long-term water-retaining property of the stratum corneum is achieved, the molting phenomenon is improved, and the barrier function is enhanced.
The applicant states that the composition with moisturizing effect and the application thereof are illustrated by the above examples, but the invention is not limited to the above examples, that is, the invention does not mean that the invention is implemented only by relying on the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
Claims (10)
1. A composition with moisturizing effect is characterized by comprising polyglycerol, lactobionic acid and nicotinamide.
2. The composition with moisturizing effect as claimed in claim 1, wherein the mass ratio of the polyglycerol, the lactobionic acid and the nicotinamide is (2-4): (1-2), preferably 3:3: 1.
3. Composition with moisturizing efficacy according to claim 1 or 2, characterized in that the polyglycerol comprises any one or a combination of at least two of polyglycerol-2, polyglycerol-4, polyglycerol-6, polyglycerol-8 or polyglycerol-10, preferably polyglycerol-6.
4. Use of the composition having moisturizing effect according to any one of claims 1 to 3 for preparing cosmetics.
5. The use according to claim 4, wherein the moisturizing composition is added in an amount of 5-20% by mass of the cosmetic.
6. The moisturizing emulsion is characterized by comprising the following components in percentage by mass: 5-20% of the moisturizing composition according to any one of claims 1-3, 0.5-2% of an emulsifier, 1-5% of oil and fat, 0.05-0.5% of a thickener, and the balance of water.
7. The moisturizing emulsion of claim 6, wherein the emulsifier is polyglyceryl-3 methyl glucose distearate;
preferably, the grease is mineral oil;
preferably, the thickener is a carbomer;
preferably, the moisturizing emulsion further comprises 0.1-0.3% of a pH regulator;
preferably, the pH adjusting agent is triethanolamine;
preferably, the moisturizing emulsion further comprises 0.1-1% of a preservative;
preferably, the preservative comprises any one or a combination of at least two of methylparaben, ethylparaben or phenoxyethanol;
preferably, the moisturizing emulsion further comprises 0.01-0.05% of a solubilizer;
preferably, the solubilizer is PEG-40 hydrogenated castor oil;
preferably, the moisturizing emulsion further comprises 0.01-0.05% of a fragrance;
preferably, the fragrance is a perfume.
8. The method for preparing a moisturizing emulsion according to claim 6 or 7, comprising the steps of:
(1) mixing and stirring an emulsifier and grease to obtain an oil phase mixed solution; mixing and stirring a thickening agent and water to obtain a water-phase mixed solution;
(2) mixing the oil phase mixed solution and the water phase mixed solution obtained in the step (1), and shearing at a high speed to obtain a pre-emulsion;
(3) and (3) mixing and stirring the pre-emulsion obtained in the step (2) and the rest components to obtain the moisturizing emulsion.
9. The preparation method of the moisturizing emulsion according to claim 8, wherein the temperature for mixing and stirring the emulsifier and the oil in the step (1) is 60-90 ℃, and the time for mixing and stirring is 10-30 min;
preferably, the temperature for mixing and stirring the composition with moisturizing effect, the thickening agent and the water in the step (1) is 70-90 ℃, and the time for mixing and stirring is 10-30 min;
preferably, the rotation speed of the high-speed shearing in the step (2) is 10000-;
preferably, the temperature of the mixing and stirring in the step (3) is below 45 ℃, and the time of the mixing and stirring is 10-20 min.
10. The method for preparing a moisturizing emulsion according to claim 8 or 9, comprising the steps of:
(1) mixing emulsifier and oil at 60-90 deg.C, stirring for 10-30min to obtain oil phase mixed solution;
mixing thickener and water at 70-90 deg.C, stirring for 10-30min to obtain water phase mixed solution;
(2) mixing the oil phase mixed solution and the water phase mixed solution obtained in the step (1), and shearing at a high speed of 10000-;
(3) mixing and stirring the pre-emulsion obtained in the step (2), the composition with moisturizing effect, a pH regulator, a preservative, a solubilizer and an aromatic at the temperature of below 45 ℃ for 10-20min to obtain the moisturizing emulsion.
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