CN111184807A - Traditional Chinese medicine composition for dispelling effects of alcohol and preparation method thereof - Google Patents
Traditional Chinese medicine composition for dispelling effects of alcohol and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition, which comprises the following medicinal components in parts by weight: 2-4 parts of vine tea, 2-4 parts of momordica grosvenori, 2-4 parts of lily, 2-4 parts of dark plum, 2-4 parts of mulberry leaf, 2-4 parts of flower of kudzuvine and 1-4 parts of liquorice. The traditional Chinese medicine composition is prepared by adopting medicinal and edible plants as raw materials, has the activities of sobering up and protecting liver, and can be used for treating, preventing and/or relieving diseases or sub-health conditions which can be treated, prevented and/or relieved by reducing the activity of glutamic-pyruvic transaminase. Compared with the existing chemical and Chinese medicinal preparation anti-alcoholism products on the market, the anti-alcoholism product has the advantages of no toxic or side effect, wide raw material source and simple preparation process, can obviously improve various uncomfortable symptoms after drinking, and achieves the effects of quickly relieving alcoholism, protecting liver and treating both principal and secondary aspects of the disease.
Description
Technical Field
The invention belongs to the field of medicine, and relates to a traditional Chinese medicine composition for relieving alcoholism and a preparation method thereof.
Background
The number of people who are happy in China is large, about 60-75% of adult men often drink the wine, and the disease proportion induced by excessive drinking increases year by year. Excessive drinking can not only cause liver damage and corresponding liver pathological changes, but also cause other diseases, especially physiological dysfunction and death of human body. Alcoholic liver injury caused by excessive drinking has become one of the most important factors for liver diseases, and excessive drinking causes malignant diseases such as hypertension and gastric cancer, and metabolic disorders of substances such as proteins. The most common poison causing liver damage is alcohol, and liver damage caused by excessive drinking has become a worldwide medical problem. Therefore, the demands of sobering up, relieving alcoholism and reducing the damage of drinking to human organs such as stomach intestine, liver and the like are urgent, and the development of effective anti-alcoholism medicines has important significance and broad market prospect.
At present, the antialcoholic products on the market mainly comprise chemical drugs and traditional Chinese medicine preparations. Most of the chemical drugs for relieving the effect of alcohol are stimulants, vitamins, amino acids and other components, and can quickly play roles in relieving the effect of alcohol, but most of the chemical drugs for relieving the effect of alcohol only can promote the decomposition of alcohol to play a role in temporary relief, so that the effect of protecting liver is hardly played, and the toxic and side effects are great. The traditional Chinese medicine preparation for relieving alcoholism has complex raw material components and complex preparation process, and is difficult to effectively improve various symptoms after drinking to achieve the effects of quickly relieving alcoholism and treating both principal and secondary aspects of disease.
Disclosure of Invention
In order to solve the defects of the prior art, the invention provides a traditional Chinese medicine composition in a first aspect, wherein medicinal ingredients of the traditional Chinese medicine composition are prepared from the following traditional Chinese medicinal materials: ampelopsis grossedentata, momordica grosvenori, lily, dark plum, mulberry leaf, pueraria flower and liquorice.
In some embodiments, the medicinal ingredients of the traditional Chinese medicine composition are prepared from the following traditional Chinese medicinal materials in parts by weight: 1-10 parts of vine tea, 1-10 parts of momordica grosvenori, 1-10 parts of lily, 1-10 parts of dark plum, 1-10 parts of mulberry leaf, 1-10 parts of flower of kudzuvine and 1-10 parts of liquorice.
In some embodiments, the medicinal ingredients of the traditional Chinese medicine composition are prepared from the following traditional Chinese medicinal materials in parts by weight: 2-4 parts of vine tea, 2-4 parts of momordica grosvenori, 2-4 parts of lily, 2-4 parts of dark plum, 2-4 parts of mulberry leaf, 2-4 parts of flower of kudzuvine and 1-4 parts of liquorice.
In a second aspect, the present invention provides a method for preparing the Chinese medicinal composition according to the first aspect of the present invention, the method comprising the steps of:
(1) mixing the traditional Chinese medicines to form a traditional Chinese medicine mixture;
(2) boiling the traditional Chinese medicine mixture for 0.5-2 hours, wherein the weight ratio of the traditional Chinese medicine mixture to water is 1: 5-20 to obtain a first mixed solution;
(3) filtering the first mixed solution, centrifuging the filtrate at 3500-4500r/min for 10-20min, and taking the supernatant to obtain a second mixed solution;
(4) adding 2-5 times volume of anhydrous ethanol into the second mixed solution, standing at 3-5 deg.C for 12-36h for alcohol precipitation, centrifuging at 3500-.
In some embodiments, the Chinese medicinal mixture in step (1) is pulverized and sieved with a 80-120 mesh sieve.
In some embodiments, in the step (2), the mixture of Chinese herbs is soaked for 12-36 hours before boiling.
In a third aspect, the present invention provides a method for preparing the Chinese medicinal composition according to the first aspect of the present invention, the method comprising the steps of:
(a) mixing the Chinese medicinal materials;
(b) soaking in water
(c) Boiling;
(d) filtering;
(e) and concentrating the filtrate to obtain the traditional Chinese medicine composition.
In a fourth aspect, the present invention provides a method for preparing the Chinese medicinal composition according to the first aspect of the present invention, the method comprising the steps of:
(i) mixing the Chinese medicinal materials;
(ii) pulverizing the Chinese medicinal mixture;
(iii) soaking in water;
(iv) filtering;
(v) and concentrating the filtrate to obtain the traditional Chinese medicine composition.
In a fifth aspect, the present invention provides a use of the Chinese medicinal composition according to the first aspect or the Chinese medicinal composition prepared by the method according to the second, third or fourth aspect of the present invention for sobering up and protecting liver.
A sixth aspect of the invention provides the use of a method according to the second, third or fourth aspect of the invention in the manufacture of a medicament or healthcare product for the treatment, prevention and/or alleviation of a disease or sub-health condition treatable, prevented and/or alleviated by decreasing glutamate pyruvate transaminase activity.
Detailed Description
In order to better explain the technical solution of the present invention, the following detailed description of various embodiments of the present invention is provided.
Example 1: preparation of Chinese medicinal stock solution
Preparing a lily extract stock solution: pulverizing Bulbus Lilii with a traditional Chinese medicine pulverizer, and sieving with 100 mesh sieve. Taking 20g of sieved lily powder, adding 1000mL of distilled water, soaking for 24h, boiling for 1h, filtering by using gauze, taking filtrate, centrifuging for 15min at 4000r/min, taking supernatant, adding 3 times of volume of absolute ethyl alcohol, standing at 4 ℃ for 24h for alcohol precipitation, centrifuging for 15min at 4000r/min, removing supernatant, and dissolving precipitate in 100mL of distilled water to obtain lily extract stock solution.
Respectively and independently preparing the raw liquid of the extracts of the liquorice, the momordica grosvenori, the vine tea, the chrysanthemum, the mulberry leaf, the smoked plum, the kudzu root, the pueraria flower and the lotus leaf by the same method and steps.
Example 2: testing of effectiveness of extracts of Chinese herbs
Medicine preparation: ten kinds of Chinese medicinal raw liquids extracted in example 1.
Test animals: BalB/C mice.
Glutamate-pyruvate transaminase activity determination kit: purchased from Nanjing to build a bioengineering institute.
Wine for test: 43 degree red star Erguotou white spirit.
132 male BalB/C mice were taken and randomly divided into 12 groups of 11 mice each (each of the other tests of the invention was a duplicate of 11 mice).
The mice are fasted for 12 hours before the test, the blank group is not treated by wine filling, each mouse of the test group is subjected to stomach filling by using white spirit according to the weight of 0.1ml/10g, after 45 minutes of wine filling, the control group is given distilled water, the stomach filling dose is 0.1ml/10g, and ten test groups are respectively subjected to stomach filling by using ten traditional Chinese medicine stock solutions extracted in the example 1, and the dose is 0.1ml/10 g.
After 0.5 min, 1h, 2h, 4h of administration, the mice were placed in the center of a vertically suspended metal net and the time for the mice to climb on the metal net, i.e., the time for the mice to fall off the metal net after being placed on the metal net, was recorded, and the results are shown in table 1 (unless otherwise specified, the data reported in this document are average values).
Each mouse was administered wine in the same manner and dose for 6 consecutive days, and 2 hours after the next day. On day 6 of continuous dosing, mice were bled from the fundus venous plexus. Serum was isolated and glutamate pyruvate transaminase GPT activity in serum was determined according to the kit instructions and the results are shown in table 2.
TABLE 1 mice climb time on day 1 (units: seconds, average)
TABLE 2 serum GPT assay results (Unit: Karman Unit, average value)
| Group of | GPT Activity |
| Blank space | 55.4 |
| Control | 96.4 |
| Chrysanthemum flower | 85.7 |
| Licorice root, radix Glycyrrhizae | 90.1 |
| Vine tea | 78.5 |
| Kudzu root | 85.9 |
| Flower of kudzuvine | 87.7 |
| Mulberry leaf | 89.4 |
| Lotus leaf | 86.3 |
| Lily bulb | 81.0 |
| Dark plum fruit | 82.3 |
| Momordica grosvenori | 79.4 |
As can be seen from the data in tables 1 and 2, the anti-hangover effects of the ten traditional Chinese medicine stock solutions are greatly different. Considering that the mice are influenced by random factors such as fright, the climbing time is greatly influenced, and the random factor of the GPT result is less influenced, so that ten related traditional Chinese medicines are sorted from small to large in GPT activity. Ampelopsis grossedentata, momordica grosvenori, lily, dark plum, chrysanthemum, radix puerariae, lotus leaf, pueraria flower, mulberry leaf and liquorice. The sequence of the mouse climbing time from long to short is not completely consistent, but basically accords with the sequence.
Example 3: test of the Combined Effect of extracts of Chinese herbs
The same procedure as in example 2 was followed, except that the gavage was carried out by mixing a plurality of drug stocks, and the gavage dose was a mixture of 0.1ml/10g of the body weight of each of the drug stocks (the same applies hereinafter in the present invention).
The best results of the test were obtained by adding one additional drug to the first quanday vine tea, momordica grosvenori, lily, and smoked plum, and the results are shown in table 3.
TABLE 3 mice day 1 time of attachment (unit: seconds, averaged) and 6 days after administration serum GPT measurements (unit: Karman unit, averaged)
| Group of | 2h of drug administration | GPT Activity |
| Ampelopsis grossedentata, momordica grosvenori, lily and dark plum | 190.4 | 74.5 |
| Ampelopsis grossedentata, momordica grosvenori, lily, dark plum and chrysanthemum | 261.7 | 76.2 |
| Ampelopsis grossedentata, momordica grosvenori, lily, dark plum and kudzu root | 236.4 | 73.4 |
| Ampelopsis grossedentata, momordica grosvenori, lily, dark plum and lotus leaf | 251.7 | 78.4 |
| Ampelopsis grossedentata, momordica grosvenori, lily, dark plum fruit and pueraria flower | 245.1 | 72.7 |
| Ampelopsis grossedentata, momordica grosvenori, lily, dark plum fruit and mulberry leaf | 273.5 | 65.4 |
| Ampelopsis grossedentata, momordica grosvenori, lily, dark plum and liquorice | 207.8 | 71.6 |
As can be seen from Table 3, the combination of Ampelopsis grosvenori, Momordica grosvenori, Lily bulb, Prunus mume and Morus alba leaf is obviously better than other combinations, and then the Ampelopsis grosvenori, Momordica grosvenori, Lily bulb, Prunus mume and Morus alba leaf are added with one other medicine for testing, and the results are shown in Table 4.
TABLE 4 mice day 1 time of attachment (unit: seconds, averaged) and 6 days after administration serum GPT measurements (unit: Karman unit, averaged)
As can be seen from Table 4, the combination of Ampelopsis grossedentata, Momordica grosvenori, Lily bulb, Prunus mume, Morus alba leaf, and Pueraria lobata is significantly better than other combinations, and then, the Ampelopsis grossedentata, Momordica grossedentata, Lilium lilium, Prunus mume, Morus alba leaf, and Pueraria lobata are added with one other medicine, and the test results are shown in Table 5.
TABLE 5 mice day 1 time of attachment (unit: seconds, averaged) and 6 days after administration serum GPT measurements (unit: Karman unit, averaged)
As can be seen from the data in table 5, the combined effect of the ampelopsis grossedentata, the momordica grosvenori, the lily, the dark plum, the mulberry leaf, the pueraria flower and the licorice is the best overall, but is not improved significantly, so that the medicinal materials are not required to be added, and the combination of the ampelopsis grossedentata, the momordica grossedentata, the lily, the dark plum, the mulberry leaf, the pueraria flower and the licorice is used as the prescription of the invention.
Example 4: preparation and effect test of traditional Chinese medicine composition
Preparation of composition 1:
mixing Ampelopsis grossedentata 20g, Momordica grosvenori 10g, Bulbus Lilii 10g, mume fructus 10g, folium Mori 10g, flos Puerariae Lobatae 10g, and Glycyrrhrizae radix 5 g.
Pulverizing the above mixture with a traditional Chinese medicine pulverizer, and sieving with 100 mesh sieve. Soaking the sieved medicinal powder in 1000mL of distilled water for 24h, boiling for 1h, filtering with gauze, centrifuging the filtrate at 4000r/min for 15min, taking the supernatant, adding 3 times of volume of absolute ethyl alcohol, standing at 4 ℃ for 24h for alcohol precipitation, centrifuging at 4000r/min for 15min, removing the supernatant, and dissolving the precipitate in 100mL of distilled water to obtain the composition 1 stock solution.
Preparation of composition 2:
the difference from the composition 1 is that 10g of vine tea, 20g of momordica grosvenori, 10g of lily, 10g of dark plum, 10g of mulberry leaf, 10g of flower of kudzuvine and 5g of liquorice are mixed.
Preparation of composition 3:
the difference from the composition 1 is that 10g of vine tea, 10g of momordica grosvenori, 20g of lily, 10g of dark plum, 10g of mulberry leaf, 10g of flower of kudzuvine and 5g of liquorice are mixed.
Preparation of composition 4:
the difference from the composition 1 is that 10g of vine tea, 10g of momordica grosvenori, 10g of lily, 20g of dark plum, 10g of mulberry leaf, 10g of pueraria flower and 5g of liquorice are mixed.
Preparation of composition 5:
the difference from the composition 1 is that 10g of vine tea, 10g of momordica grosvenori, 10g of lily, 10g of dark plum, 20g of mulberry leaf, 10g of pueraria flower and 5g of liquorice are mixed.
Preparation of composition 6:
the difference from the composition 1 is that 10g of vine tea, 10g of momordica grosvenori, 10g of lily, 10g of dark plum, 10g of mulberry leaf, 20g of pueraria flower and 5g of liquorice are mixed.
Preparation of composition 7:
the difference from the composition 1 is that 10g of vine tea, 10g of momordica grosvenori, 10g of lily, 10g of dark plum, 10g of mulberry leaf, 10g of flower of kudzuvine and 10g of liquorice are mixed.
Preparation of composition 8:
the difference from the composition 1 is that 10g of vine tea, 10g of momordica grosvenori, 10g of lily, 10g of dark plum, 10g of mulberry leaf, 10g of flower of kudzuvine and 20g of liquorice are mixed.
Preparation of composition 9:
mixing Ampelopsis grossedentata 20g, Momordica grosvenori 10g, Bulbus Lilii 10g, mume fructus 10g, folium Mori 10g, flos Puerariae Lobatae 10g, and Glycyrrhrizae radix 5 g.
Soaking in 1000mL of distilled water for 24h, boiling for 1h, filtering with gauze, heating the filtrate, and concentrating to 100 mL.
Preparation of composition 10:
mixing Ampelopsis grossedentata 20g, Momordica grosvenori 10g, Bulbus Lilii 10g, mume fructus 10g, folium Mori 10g, flos Puerariae Lobatae 10g, and Glycyrrhrizae radix 5 g.
Pulverizing the above mixture with a traditional Chinese medicine pulverizer, and sieving with 100 mesh sieve. Soaking the sieved medicinal powder in 1000mL of distilled water for 24h, filtering with gauze, heating the filtrate, and concentrating to 100 mL.
Gavage was carried out in the same manner as in example 2 at a gavage dose of 0.1ml/10g body weight, and the mice were tested for the 1 st day climbing time and for the serum GPT activity 6 days after administration, and the results are shown in Table 6.
TABLE 6 mice day 1 climb time (unit: seconds, average value) and 6 days after administration serum GPT measurement (unit: Karman unit, average value)
As can be seen from the data in table 6 above, the effects of compositions 1-10 are not significantly different, all are able to significantly increase the silk screen climbing time after drinking mice relative to the control, and GPT activity can be maintained at near or slightly below blank levels. The composition 1-10 can have the effects of relieving alcoholism and protecting liver.
The traditional Chinese medicine composition is prepared by adopting medicinal and edible plants as raw materials, has the activities of sobering up and protecting liver, and can be used for treating, preventing and/or relieving diseases or sub-health conditions which can be treated, prevented and/or relieved by reducing the activity of glutamic-pyruvic transaminase. Compared with the existing chemical and Chinese medicinal preparation anti-alcoholism products on the market, the anti-alcoholism product has the advantages of no toxic or side effect, wide raw material source and simple preparation process, can obviously improve various uncomfortable symptoms after drinking, and achieves the effects of quickly relieving alcoholism, protecting liver and treating both principal and secondary aspects of the disease.
All equivalent changes and obvious modifications made based on the conception of the invention fall into the protection scope of the invention.
Claims (10)
1. A traditional Chinese medicine composition comprises the following medicinal components: ampelopsis grossedentata, momordica grosvenori, lily, dark plum, mulberry leaf, pueraria flower and liquorice.
2. The traditional Chinese medicine composition of claim 1, wherein the medicinal ingredients of the traditional Chinese medicine composition are derived from the following traditional Chinese medicinal materials in parts by weight: 1-10 parts of vine tea, 1-10 parts of momordica grosvenori, 1-10 parts of lily, 1-10 parts of dark plum, 1-10 parts of mulberry leaf, 1-10 parts of flower of kudzuvine and 1-10 parts of liquorice.
3. The traditional Chinese medicine composition of claim 1, wherein the medicinal ingredients of the traditional Chinese medicine composition are derived from the following traditional Chinese medicinal materials in parts by weight: 2-4 parts of vine tea, 2-4 parts of momordica grosvenori, 2-4 parts of lily, 2-4 parts of dark plum, 2-4 parts of mulberry leaf, 2-4 parts of flower of kudzuvine and 1-4 parts of liquorice.
4. A method of preparing the traditional Chinese medicine composition of claims 1 to 3, the method comprising the steps of:
(1) mixing the traditional Chinese medicines to form a traditional Chinese medicine mixture;
(2) boiling the traditional Chinese medicine mixture for 0.5-2 hours, wherein the weight ratio of the traditional Chinese medicine mixture to water is 1: 5-20 to obtain a first mixed solution;
(3) filtering the first mixed solution, centrifuging the filtrate at 3500-4500r/min for 10-20min, and taking the supernatant to obtain a second mixed solution;
(4) adding 2-5 times volume of anhydrous ethanol into the second mixed solution, standing at 3-5 deg.C for 12-36h for alcohol precipitation, centrifuging at 3500-.
5. The method of claim 4, wherein:
and (2) crushing the traditional Chinese medicine mixture in the step (1), and sieving the crushed mixture with a 80-120-mesh sieve.
6. The method of claim 4, wherein:
in the step (2), the traditional Chinese medicine mixture is soaked for 12-36 hours before boiling.
7. A method of preparing the traditional Chinese medicine composition of claims 1 to 3, the method comprising the steps of:
(a) mixing the Chinese medicinal materials;
(b) soaking in water
(c) Boiling;
(d) filtering;
(e) and concentrating the filtrate to obtain the traditional Chinese medicine composition.
8. A method of preparing the traditional Chinese medicine composition of claims 1 to 3, the method comprising the steps of:
(i) mixing the Chinese medicinal materials;
(ii) pulverizing the Chinese medicinal mixture;
(iii) soaking in water;
(iv) filtering;
(v) and concentrating the filtrate to obtain the traditional Chinese medicine composition.
9. Use of the Chinese medicinal composition of claims 1 to 3 and the Chinese medicinal composition prepared by the method of claims 4 to 8 for sobering up and protecting liver.
10. Use of a method according to claims 4 to 8 for the preparation of a medicament or nutraceutical for the treatment, prevention and/or alleviation of diseases or sub-health conditions treatable, prevented and/or alleviated by decreasing glutamate pyruvate transaminase activity.
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