CN105395644A - Traditional Chinese medicinal composition for preventing and treating coccidiosis in chicken as well as preparation method and application of traditional Chinese medicinal composition - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for preventing and treating chicken coccidiosis, which is prepared from the following components in parts by weight: 5 parts of duck gall, 5 parts of pulsatilla, 5 parts of artemisia annua, and 3 parts of Burnet , 3 parts of Atractylodes macrocephala, 3 parts of agrimony, 2 parts of licorice, 2 parts of woody fragrance, 2 parts of chamaejasma; and provide its preparation method and application. A traditional Chinese medicine composition for preventing and treating chicken coccidiosis provided by the present invention and its preparation method and application have the following beneficial effects: (1) can effectively prevent and treat the occurrence of chicken coccidiosis; (2) can use drinking water to provide (3) Since the present invention is a Chinese herbal medicine preparation, problems such as drug resistance are avoided, and the probability of control failure is greatly reduced; (4) The present invention is a pure Chinese medicine compound, which is low in chicken body. Residue, good biological safety.

Description

A kind of traditional Chinese medicine composition for preventing and treating chicken coccidiosis and its preparation method and application

technical field

The invention relates to the technical field of traditional Chinese medicine compositions for livestock and poultry, in particular to a traditional Chinese medicine composition for preventing and treating chicken coccidiosis and its preparation method and application.

Background technique

Chicken coccidiosis (Chicken coccidiosis) is a protozoan disease caused by one or more coccidia of the genus Eimeria parasitizing in chicken intestinal epithelial cells. 20% to 30%, and the fatality rate is as high as 80% in severe cases. The disease is extremely harmful to the chicken industry, especially in the development of large-scale and intensive poultry industry today. global disease of development. Worldwide losses due to coccidiosis are approximately £2 billion per year. In chicken production, almost all chick feeds must add anticoccidial drugs. The average annual cost of drugs to prevent this disease in my country is 0.2 to 0.3 yuan per chicken. Up to hundreds of millions of yuan, accounting for nearly 1/3 of the total cost of chicken disease prevention and treatment. For a long time, the control of chicken coccidiosis has mainly relied on chemical drugs. Due to the improper use and misuse of anticoccidial drugs, coupled with the long-term natural selection, the drug-resistant strains of coccidia are increasing day by day, resulting in many The control effect of anticoccidial drugs is significantly reduced, or even completely ineffective, which greatly shortens the service life of anticoccidial drugs; at the same time, continuous use of high doses of chemical drugs to prevent and control coccidiosis will also cause drug residues and endanger human beings. In addition, in the process of preventing and treating chicken coccidiosis, although live vaccines are used, they have not been widely used because they are prone to strong virulence and DNA vaccine research is not complete. Since Chinese herbal medicines are mostly natural herbal medicines, the use of traditional Chinese medicines to prevent chicken coccidiosis can not only achieve the purpose of preventing coccidiosis, but also alleviate the problem of affecting the export of broiler chickens due to veterinary drug residues. Therefore, the development of safe and efficient preparations for the prevention and treatment of chicken coccidiosis has a good market prospect.

Contents of the invention

The purpose of the present invention is aimed at the defects in the above-mentioned prior art, and provides a kind of traditional Chinese medicine composition for preventing and treating chicken coccidiosis with good effect, low residue and good biological safety and preparation method thereof and apply.

In order to achieve the above object, the technical solution provided by the present invention is: a traditional Chinese medicine composition for preventing and treating chicken coccidiosis, which is prepared from the following components in parts by weight: 5 parts of duck gallbladder, 5 parts of Pulsatilla grandis, 5 parts of Artemisia annua, 3 parts of Burnet, 3 parts of Atractylodes macrocephala, 3 parts of Agrimony, 2 parts of licorice, 2 parts of woody fragrance, and 2 parts of chamaejamas.

Further, the above-mentioned traditional Chinese medicine composition for preventing and treating chicken coccidiosis also includes a pharmaceutically acceptable preservative.

Further, in the above-mentioned traditional Chinese medicine composition for preventing and treating coccidiosis in chickens, the preservatives are 3 parts by weight of potassium sorbate and 3 parts of sodium diacetate.

Second object of the present invention is to provide above-mentioned a kind of preparation method that is used for preventing and treating chicken coccidiosis Chinese medicine composition, comprises the following steps:

1) Sorting: remove impurities in each Chinese medicine component;

2) Pulverization: After weighing and mixing each component according to the proportion, pulverize into 200-mesh fine powder;

3) Soaking and decocting for extraction: Soak the crushed medicinal powder in clear water with 5 times the weight of the medicinal powder at room temperature for 3 hours, and then decoct for 2 hours to extract after the water is boiled;

4) Second soaking and decocting extraction: soak the drug residue separated after the first soaking and extraction with water 5 times the weight of the original drug powder at room temperature for 1 hour, and then decoct for 2 hours after the water is boiled to extract;

5) Combining medicinal liquids: separate the decoction liquids and medicinal residues twice before merging them;

6) Concentration: Concentrate the decoction-extracted and combined medicinal liquid into a concentrated liquid that is 1 times the weight of the original medicinal powder;

7) Filter to remove impurities;

8) Add preservatives according to the weight ratio;

9) Packing.

The third object of the present invention is to provide the application of the above-mentioned traditional Chinese medicine composition for preventing and treating coccidiosis in chickens in the preparation of medicaments for preventing and treating coccidiosis in chickens.

Further, the above-mentioned application is to feed the Chinese medicine composition after drinking water at a ratio of 1:100, twice a day for 3-5 consecutive days.

A kind of traditional Chinese medicine composition for preventing and treating chicken coccidiosis provided by the present invention and its preparation method and application have the following beneficial effects:

(1) It can effectively prevent the occurrence of chicken coccidiosis;

(2) Drinking water can be used for drug administration, with simple operation and low cost;

(3) Since the present invention is a Chinese herbal medicine preparation, the occurrence of problems such as drug resistance is avoided, and the probability of failure in prevention and treatment is greatly reduced;

(4) The present invention is a pure traditional Chinese medicine compound with low residue in chickens and good biological safety.

detailed description

Example 1:

A traditional Chinese medicine composition for preventing and treating chicken coccidiosis, which is prepared from the following components: 5 kg of duck gall, 5 kg of pulsatilla, 5 kg of Artemisia annua, 3 kg of Burnet, 3 kg of Atractylodes macrocephala, 3 kg of agrimony, 2 kg of licorice, and woody 2kg, wolfbane 2kg.

Its preparation method comprises the following steps:

1) Sorting: remove impurities in each Chinese medicine component;

2) Pulverization: After weighing and mixing each component according to the proportion, pulverize into 200-mesh fine powder;

3) Soaking and decocting for extraction: Soak the crushed medicinal powder in clear water with 5 times the weight of the medicinal powder at room temperature for 3 hours, and then decoct for 2 hours to extract after the water is boiled;

4) Second soaking and decocting extraction: soak the drug residue separated after the first soaking and extraction with water 5 times the weight of the original drug powder at room temperature for 1 hour, and then decoct for 2 hours after the water is boiled to extract;

5) Combining medicinal liquids: separate the decoction liquids and medicinal residues twice before merging them;

6) Concentration: Concentrate the decoction-extracted and combined medicinal liquid into a concentrated liquid that is 1 times the weight of the original medicinal powder;

7) Filter to remove impurities;

8) Packing.

Example 2:

A traditional Chinese medicine composition for preventing and treating chicken coccidiosis, which is prepared from the following components: 5 kg of duck gall, 5 kg of pulsatilla, 5 kg of Artemisia annua, 3 kg of Burnet, 3 kg of Atractylodes macrocephala, 3 kg of agrimony, 2 kg of licorice, and woody 2kg, wolfbane 2kg, potassium sorbate 3kg and sodium diacetate 3kg as preservatives.

Its preparation method comprises the following steps:

1) Sorting: remove impurities in each Chinese medicine component;

2) Pulverization: After weighing and mixing each component according to the proportion, pulverize into 200-mesh fine powder;

3) Soaking and decocting for extraction: Soak the crushed medicinal powder in clear water with 5 times the weight of the medicinal powder at room temperature for 3 hours, and then decoct for 2 hours to extract after the water is boiled;

4) Second soaking and decocting extraction: soak the drug residue separated after the first soaking and extraction with water 5 times the weight of the original drug powder at room temperature for 1 hour, and then decoct for 2 hours after the water is boiled to extract;

5) Combining medicinal liquids: separate the decoction liquids and medicinal residues twice before merging them;

6) Concentration: Concentrate the decoction-extracted and combined medicinal liquid into a concentrated liquid that is 1 times the weight of the original medicinal powder;

7) Filter to remove impurities;

8) Add preservatives according to the weight ratio;

9) Packing.

Example 3:

Application example:

Get a total of 90.0kg of the original medicinal materials, the weight of each original medicinal material is respectively: duck guts 15.0kg, Pulsatilla 15.0kg, Artemisia annua 15.0kg, Burnet 9.0kg, Atractylodes macrocephala 9.0kg, Agrimony 9.0kg, licorice 6.0kg, woody fragrance 6.0kg kg, wolfbane 6.0kg. After sorting and crushing into 200-mesh fine powder, soak the crushed medicinal powder with 5 times the weight of the medicinal product, that is, 450.0 kg of clear water at room temperature for 3 hours, decoct for 2 hours, separate the medicinal liquid and the medicinal residue, and keep the medicinal liquid for later use. Then add the separated drug residue to 5 times the weight of the original drug powder, soak in water at room temperature for 1 hour, decoct for 2 hours, separate the drug solution, mix the extracted drug solution twice, and concentrate it into a concentrated solution of 1 times the weight of the original drug powder , filter, add 9.0g Potassium Sorbate and 9.0g Sodium Diacetate preservatives, pack and make finished product, the following is specific application situation:

(1) Of the 12,900 43-day-old laying hens in Xigu Chicken Farm in Gansu, 60% of them suffered from malaise, erect feathers, eyes closed and neck shrinkage, full crops, loss of appetite or even extinction. The chickens mainly show loose feces, blood in the feces or brownish red in the feces, and the feathers around the anus are polluted by blood. Individual chickens have pale chicken skin, cockscomb, cloaca, oral mucosa and conjunctiva, and even symptoms such as ataxia, drooping wings, nerve paralysis or convulsions. Autopsy of sick chickens shows that the cecum is flat and significantly enlarged, and the intestinal cavity is full of blood or blood coagulation or bean dregs-like necrosis, the serosa surface turns brownish red, the mucosa is hypertrophic and eroded, the cecum is hardened and brittle, and some chickens that died naturally have rectal ulcers. Gray-white ring with necrosis. According to epidemiology, clinical symptoms, autopsy changes and coccidia oocyst microscopic examination, it was confirmed that coccidiosis occurred in chicken flocks, and chicken coccidiosis was diagnosed. The Chinese herbal medicine extract preparation prepared by the above method is diluted with water at a ratio of 1:50 for treatment, twice a day for 5 consecutive days. After 3 days of medication, the symptoms were significantly relieved. After 5 days, the spirit, food intake and drinking water of the whole flock returned to normal, and the disease was effectively controlled. The cure rate was 88.4%, and the effective rate was 100%.

(2) Chicken coccidiosis occurred in 3,600 chickens raised on the ground in Tianshui chicken farm in Gansu Province. The Chinese herbal medicine extract preparation prepared by the above method was diluted with water at a ratio of 1:50 and then given to the chickens for drinking, twice a day for 5 consecutive days. On the second day afterward, the symptoms of 73.4% of the sick chickens were significantly relieved, and the disease was under control on the fourth day, with a cure rate of 89.4% and an effective rate of 100%.

(3) Coccidiosis occurred in 4,500 chickens in broiler chicken farms in Longnan City, Gansu Province. The Chinese herbal medicine extract preparation for preventing and treating coccidiosis prepared by the above method was diluted with water at a ratio of 1:50 and then given to chickens for drinking, twice a day. On the 2nd day, the feeding, drinking and mental status of the chickens were significantly improved. On the 5th day, the respiratory symptoms of the chickens disappeared, and the disease was under control. The cure rate was 89.2%, and the effective rate was 100%.

Finally, it should be noted that: the above is only a preferred embodiment of the present invention, and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, it still The technical solutions recorded in the foregoing embodiments may be modified, or some technical features thereof may be equivalently replaced. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included within the protection scope of the present invention.

Claims (6)

1. A Chinese medicine composition for preventing and treating chicken coccidiosis is characterized in that it is prepared from the following components in parts by weight: 5 parts of duck gallbladder, 5 parts of Pulsatilla chinensis, 5 parts of Artemisia annua, Burnet burnet 3 parts, 3 parts of Atractylodes macrocephala, 3 parts of agrimony, 2 parts of licorice, 2 parts of woody fragrance, 2 parts of chamaejamas. 2. a kind of Chinese medicine composition for preventing and treating chicken coccidiosis according to claim 1 is characterized in that, also comprises pharmaceutically acceptable antiseptic. 3. a kind of Chinese medicine composition that is used for preventing and treating chicken coccidiosis according to claim 2 is characterized in that, described preservative is 3 parts of potassium sorbate and 3 parts of sodium diacetate by weight. 4. according to the preparation method of a kind of Chinese medicine composition for preventing and treating chicken coccidiosis described in any one of claim 1-3, it is characterized in that, comprises the following steps: 1) Sorting: remove impurities in each Chinese medicine component; 2) Pulverization: After weighing and mixing each component according to the proportion, pulverize into 200-mesh fine powder; 3) Soaking and decocting for extraction: Soak the crushed medicinal powder in clear water with 5 times the weight of the medicinal powder at room temperature for 3 hours, and then decoct for 2 hours to extract after the water is boiled; 4) Second soaking and decocting extraction: soak the drug residue separated after the first soaking and extraction with water 5 times the weight of the original drug powder at room temperature for 1 hour, and then decoct for 2 hours after the water is boiled to extract; 5) Combining medicinal liquids: separate the decoction liquids and medicinal residues twice before merging them; 6) Concentration: Concentrate the decoction-extracted and combined medicinal liquid into a concentrated liquid that is 1 times the weight of the original medicinal powder; 7) Filter to remove impurities; 8) Add preservatives according to the weight ratio; 9) Packing. 5. according to claim 1-3 arbitrary described a kind of Chinese medicine composition for preventing and treating chicken coccidiosis in the application in the medicine that is prepared for preventing and treating chicken coccidiosis. 6. The application according to claim 5, characterized in that, the traditional Chinese medicine composition is fed after drinking water at a ratio of 1:100, twice a day for 3-5 consecutive days.