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CN110812628B - Medical atomizing device based on multi-micro-pore array electrostatic atomization - Google Patents

Medical atomizing device based on multi-micro-pore array electrostatic atomization Download PDF

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Publication number
CN110812628B
CN110812628B CN201911177954.9A CN201911177954A CN110812628B CN 110812628 B CN110812628 B CN 110812628B CN 201911177954 A CN201911177954 A CN 201911177954A CN 110812628 B CN110812628 B CN 110812628B
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micro
storage tank
gas
liquid
liquid storage
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CN110812628A (en
Inventor
霍元平
张延太
吴向阳
董自通
戴容江
贺冰
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Jiangsu University
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Jiangsu University
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00Sprayers or atomisers specially adapted for therapeutic purposes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00Anatomical parts of the body
    • A61M2210/10Trunk
    • A61M2210/1025Respiratory system

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Electrostatic Spraying Apparatus (AREA)

Abstract

The invention discloses a medical atomizing device based on multi-micro-hole array electrostatic atomization, which is characterized in that a liquid storage tank is axially arranged in a gas-liquid mixing cavity, a micro booster pump is connected above the liquid storage tank, a capillary array is arranged at the bottom of the liquid storage tank and is connected with negative high pressure, an adjusting plate and a ground polar plate are sequentially arranged below the capillary array, holes which are in one-to-one correspondence with capillaries are arranged on the adjusting plate and the ground polar plate, liquid medicine discharged from the liquid storage tank is charged and then crushed into submicron-level mist drops under the action of a high-voltage electric field between the adjusting plate and the ground polar plate, and the submicron-level liquid medicine mist drops enter respiratory tracts and lungs from a suction mask by people through a gas-liquid conveying pipe under the self weight and the pushing of a micro axial flow fan. The micro-nano processing method is adopted to prepare the novel micro-hole array electrostatic spraying module to output the superfine water mist with stable atomization flow, and the micro-hole array electrostatic spraying module has the advantages of small volume, low noise, low cost, high stability and the like, and can effectively improve the current medical atomization experience and system reliability.

Description

Medical atomizing device based on multi-micro-pore array electrostatic atomization
Technical Field
The invention belongs to the field of medical atomization, and particularly relates to an electrostatic atomization drug delivery system for breaking liquid drops into micro-liquid drops based on a multi-micro-pore array.
Background
Along with the development of productivity and the improvement of medical level, the aerosol inhalation therapy is a special crowd such as the old and young, avoids intravenous injection pain, becomes the first choice therapy of respiratory diseases, and is also the most main means of bronchopurification treatment. The method uses an atomization device to disperse the medicine (solution or powder) into tiny fog drops or particles, so that the tiny fog drops or particles are suspended in the gas and enter the respiratory tract and the lung, thereby achieving the purpose of local or systemic treatment.
The types and forms of current therapeutic nebulizers are numerous, and the purposes of the different nebulizers are determined by the respective design operating characteristics. Mechanical atomizers form the mist by different mechanical means. Such as an ultrasonic atomizer, which vibrates a liquid into microscopic droplets with energy generated by ultrasonic vibration. However, because of large atomized particles, most inhaled medicine particles can only be deposited on the upper respiratory tract such as the oral cavity, the throat and the like, can not effectively treat the lower respiratory tract diseases, and can easily cause the liquid medicine to form water drops to be hung on the inner cavity wall, so that the liquid medicine has high demand and causes the phenomenon of waste; meanwhile, the atomizer has the advantages of quick atomization, easy hypoxia, choking and the like, so that the use of the atomizer in hospitals is basically stopped. Most pneumatic atomizers have the principle of suction effect (bernoulli effect) as the basic working principle, and when high-speed air flow passes through a tiny opening of a liquid suction pipe, a negative pressure effect is generated around the high-speed air flow, and liquid required for treatment is sucked into the air flow and impacted into tiny liquid drops suspended in the air flow, so that aerosol is formed. Compared with an ultrasonic atomizer, the ultrasonic atomizer has proper atomization amount inhaled in the same treatment time, and is not easy to cause hypoxia and choking. Atomized particles are finer, can go deep into treatment of the lower respiratory tract, are not easy to collide and combine, reduce waste of liquid medicine, and the atomizer used in hospitals at present is basically the same type. However, as the demand for atomization increases, the disadvantages of air-compressed atomizers are also becoming more and more pronounced. The volume is large, the noise is large, the fear psychology is easy to generate for infants, and the atomization is resisted; the portable electric power box is not easy to carry, requires an external power supply in work, and can be used in hospitals or at home only; the stability of the medicine is affected, the air flow is impacted, and the temperature is easy to be increased, so that the stability of the medicine is affected.
Micro-grid atomizers belong to the new generation of atomizers. The spraying mode is to spray by utilizing tiny ultrasonic vibration and a net type spray head structure, and the liquid water molecular structure is scattered to generate natural and elegant superfine water mist through high-frequency resonance of the ceramic atomizing sheet, so that the efficient spraying effect is realized, the size is small, the noise is low, and the carrying and the use are convenient at any time and any place. However, this technique has a fatal disadvantage in that the micro-screen has thousands of small holes with a diameter of 3 μm, which are easily clogged after multiple use and washing, resulting in a decrease in the amount of mist or even no mist, and the durability of the mist screen is the greatest.
Disclosure of Invention
Aiming at the technical problems of atomizers in the prior art, the invention provides a medical atomizing device based on multi-micro-hole array electrostatic atomization, which adopts a micro-nano processing method to prepare a novel micro-hole array electrostatic spraying module, and controls the rotating speed of a main shaft according to actual demands, so as to output superfine water mist with stable atomization flow.
The technical scheme adopted by the invention is as follows:
The medical atomization device based on the multi-micro-pore array electrostatic atomization comprises a gas-liquid mixing cavity, wherein a liquid storage tank is axially arranged in the gas-liquid mixing cavity, a micro booster pump is connected to the upper side of the liquid storage tank, a capillary array is arranged at the bottom of the liquid storage tank and is connected with negative high pressure, an adjusting plate and a ground polar plate are sequentially arranged below the capillary array, holes which are in one-to-one correspondence with capillaries are formed in the adjusting plate and the ground polar plate, the adjusting plate is connected with the negative high pressure, and the ground polar plate is grounded; the bottom of the gas-liquid mixing cavity is connected with the suction mask through a gas-liquid conveying pipe.
Further, a dustproof filtering device is arranged at the top of the gas-liquid mixing cavity;
further, the dustproof filtering is a dust filtering net or an electric dust collector. ;
further, a downward miniature axial flow fan is arranged at the top of the gas-liquid mixing cavity;
Further, the liquid storage tank is fixed with the inner wall of the gas-liquid mixing cavity through a bracket;
Further, the outside of the bottom surface of the liquid storage tank is sprayed with a conductive coating, and the conductive coating is connected with the negative high voltage of the high-voltage electrostatic generator through a wire, so that all capillaries are provided with the negative high voltage.
Further, the adjusting plate is arranged at a vertical distance of 500 micrometers right below the capillary outlet; the ground plate is arranged at a position which is 2 cm away from the right lower part of the adjusting plate.
Furthermore, the adjusting plate and the earth plate are made of copper plates.
Further, the capillary array is composed of a plurality of capillaries perpendicular to the bottom surface of the liquid storage tank, and 8 grooves which are symmetrically distributed are formed in the outlet end surface of each capillary.
The invention has the beneficial effects that:
1. the medical atomization device designed by the invention establishes a drug delivery system based on the electrostatic atomization technology by researching various factors influencing the electrostatic spray jet, and has important innovative significance for promoting the development of the current medical atomization technology.
2. Compared with the third generation micro-grid atomizer, the atomization device designed by the invention can realize more stable liquid medicine output on the basis of meeting the requirements of excellent atomization effect, silence and portability, has quite general applicability for different dosing liquids and can ensure the reliability well.
3. According to the invention, through controlling the working condition, the average diameter of liquid drops generated by atomization can be controlled within 5 microns, and the atomization flow requirement of the medical atomizer with the same level can be easily realized by adding the array integration of the micro-spray units, which is difficult to realize by the traditional atomization method.
4. Compared with the pneumatic type atomizer commonly used in the market, the atomizer utilizing the electrostatic atomization principle can have quite low cost.
Drawings
FIG. 1 is a schematic view of a medical atomizing device based on electrostatic atomization of a multi-microporous array according to the present invention;
FIG. 2 is a schematic diagram of a micro-pore array electrostatic spray module in accordance with the present invention;
FIG. 3 is a bottom view of the micro-hole array of the present invention;
FIG. 4 is an array layout of holes in the tuning plate and ground plate of the present invention;
FIG. 5 is a bottom end view of a capillary tube in accordance with the present invention;
In the figure, 1, a gas flow valve, 2, a micro booster pump, 3, a voltage controller, 4, a micro axial flow fan, 5, a liquid storage tank, 6, a bracket, 7, a capillary tube, 8, an adjusting plate, 9, a ground electrode plate, 10, a dust filtering net, 11, a conductive coating, 12, a high-voltage electrostatic generator, 13, a gas-liquid mixing cavity, 14, a suction mask, 15 and a gas-liquid conveying pipe.
Detailed Description
The present invention will be described in further detail with reference to the drawings and examples, in order to make the objects, technical solutions and advantages of the present invention more apparent. It should be understood that the specific embodiments described herein are for purposes of illustration only and are not intended to limit the scope of the invention.
As shown in fig. 1, a medical atomization device based on multi-micro-hole array electrostatic atomization comprises a gas-liquid mixing cavity 13, wherein a dust filtering net 10 and a downward-arranged miniature axial flow fan 4 are arranged at the top opening of the gas-liquid mixing cavity 13; the dust filter screen 10 is detachable and replaceable, the dust filter screen 10 filters air flowing into the air-liquid mixing cavity 13 from the outside, so that the PM2.5 content is reduced, cleaner air is obtained when people inhale, the liquid medicine is prevented from being polluted, and the probability of cross infection is reduced.
A liquid storage tank 5 is axially arranged in the gas-liquid mixing cavity 13, and the liquid storage tank 5 is used for storing liquid medicine; the bottom of the gas-liquid mixing cavity 13 is connected with the suction mask 14 through a gas-liquid conveying pipe 15. The liquid storage tank 5 is fixed with the inner wall of the gas-liquid mixing cavity 13 by the support 6, in this embodiment, the support 6 is made of insulating material, such as nylon, and the insulating support 6 insulates the charged liquid medicine in the liquid storage tank 5 from the gas-liquid mixing cavity 13.
The top of the liquid storage tank 5 is connected with the outlet of the micro booster pump 2 through a gas pipeline, the inlet and the outlet of the micro booster pump 2 are respectively provided with a gas flow valve 1, the power line of the micro booster pump 2 is connected with a voltage controller 3, and the pressure inside the liquid storage tank 5 can be regulated through the voltage controller 3 and the gas flow valve 1, so that proper atomization flow is obtained. As shown in fig. 2, a capillary array is arranged at the bottom of the liquid storage tank 5, and the capillary array is formed by a plurality of capillaries 7 perpendicular to the bottom surface of the liquid storage tank 5; and a conductive coating 11 such as tin oxide and indium oxide is sprayed on the outer side of the bottom surface of the liquid storage tank 5; the conductive coating 11 is connected with the negative high voltage of the high voltage electrostatic generator 12 through a wire, so that all capillaries 7 are provided with the negative high voltage; an adjusting plate 8 is arranged at the position, which is opposite to the outlet of the capillary tube 7, of 500 micrometers, a ground polar plate 9 is arranged at the position, which is opposite to the position, which is 2 centimeters away from the position, which is opposite to the position, of the adjusting plate 8, holes which are in one-to-one correspondence with the capillary tube 7 are formed in the adjusting plate 8 and the ground polar plate 9, the adjusting plate 8 is connected with a negative high-voltage static electricity generating device, and the ground polar plate 9 is grounded; because each capillary tube 7 and the adjusting plate 8 have negative high pressure and have potential difference, atomized submicron liquid drops are not easy to drop due to entrainment to the end face of the liquid storage tank 5, and meanwhile, the voltage edge effect between adjacent capillary tubes 7 can be eliminated, so that the atomization stability of each capillary tube 7 is ensured. Further, a high-voltage electric field is formed between the adjusting plate 8 and the earth electrode plate 9, so that charged liquid drops are broken under the action of coulomb repulsion force; in this embodiment, the adjusting plate 8 and the ground plate 9 may be made of copper plates, the capillary tube 7 is made of stainless steel, and the diameters of the capillary tube 7 are 300-400 micrometers.
As shown in fig. 5, 8 symmetrically distributed grooves are formed in the outlet end face of the capillary tube 7, and meanwhile, the precision of the groove surface is guaranteed, so that broken charged liquid drops are easier to form a plurality of symmetrical jet flows, atomized liquid drop particles are finer, and the suction effect is better.
As shown in fig. 3 and 4, the array structures of the capillaries 7, the array structures of the holes on the adjusting plate 8 and the ground electrode plate 9 are in axisymmetric hexagonal layout, and the distance between the adjacent capillaries 7 is 1mm, so that the design can ensure that multiple jet flows emitted by the adjacent capillaries 7 are not interfered with each other, and meanwhile, the integration density is maximized, thereby being beneficial to controlling the overall size of the device.
For a clearer explanation of the technical solution protected by the present invention, the following is further explained in connection with the working process: when the voltage controller 3 is electrified, the micro booster pump 2 boosts the liquid in the liquid storage tank 5, the voltage at two ends of the micro booster pump 2 can be regulated through the voltage controller 3, so that the power of the micro booster pump 2 is regulated, and the air flow of the inlet and the outlet of the micro booster pump can be regulated through regulating the opening of the valve 1; the micro booster pump 2 injects air with certain pressure into the liquid storage tank 5 through a gas pipeline; the pressure difference exists between the gas pressure in the liquid storage tank 5 and the external atmospheric pressure, and the liquid medicine contained in the liquid storage tank is discharged through the capillary array after being subjected to the pressure difference. Since the conductive coating 11 at the bottom of the liquid storage tank 5 is connected to the negative high pressure, all capillaries and liquid medicine are brought to the negative high pressure.
The liquid medicine extruded from the end face of the capillary array is charged and then crushed into submicron-sized fog drop groups under the action of a high-voltage electric field between the adjusting plate 8 and the ground electrode plate 9, and the submicron-sized liquid medicine fog drop groups enter the respiratory tract and the lung from the suction mask 14 by a person through the gas-liquid conveying pipe 15 under the self weight and the pushing of the miniature axial flow fan 4. Meanwhile, the airflow generated by the miniature axial flow fan 4 conveys the submicron-sized fog drops to the respiratory tract of a human body, and meanwhile, backflow of fog drops is avoided, so that the nylon bracket 6 is always kept in a dry and insulating state.
In summary, compared with the micro-grid atomizer in the prior art, the micro-grid of the micro-grid atomizer consists of thousands of small holes with the diameter of 3 microns, the micro-grid atomizer is easy to block after being used and cleaned for multiple times, so that the mist output is reduced or even not output, and the problem is well avoided by adopting the multi-micro-hole array electrostatic atomization in the invention, and the atomizing flow requirement of the medical atomizer with the same level can be easily realized. In addition, compared with commonly used type atomizers such as SVN on the market, the atomizer utilizing the electrostatic atomization principle can have quite low cost and excellent silencing effect, and the electrostatic atomization has quite general applicability for different dosing liquids, so that the reliability can be well ensured.
The above embodiments are merely for illustrating the design concept and features of the present invention, and are intended to enable those skilled in the art to understand the content of the present invention and implement the same, the scope of the present invention is not limited to the above embodiments. Therefore, all equivalent changes or modifications according to the principles and design ideas of the present invention are within the scope of the present invention.

Claims (5)

1. The medical atomization device based on the multi-micro-pore array electrostatic atomization is characterized by comprising a gas-liquid mixing cavity (13), wherein a liquid storage tank (5) is axially arranged in the gas-liquid mixing cavity (13), a micro booster pump (2) is connected above the liquid storage tank (5), a capillary array is arranged at the bottom of the liquid storage tank (5), the capillary array is connected with negative high pressure, an adjusting plate (8) and a ground electrode plate (9) are sequentially arranged below the capillary array, holes which are in one-to-one correspondence with the capillaries (7) are formed in the adjusting plate (8) and the ground electrode plate (9), the adjusting plate (8) is connected with the negative high pressure, and the ground electrode plate (9) is grounded; the bottom of the gas-liquid mixing cavity (13) is connected with a suction mask (14) through a gas-liquid conveying pipe (15); a dustproof filtering device is arranged at the top of the gas-liquid mixing cavity (13); a miniature axial flow fan (4) facing downwards is arranged at the top of the gas-liquid mixing cavity (13); fixing the liquid storage tank (5) and the inner wall of the gas-liquid mixing cavity (13) through a bracket (6); the outer side of the bottom surface of the liquid storage tank (5) is sprayed with a conductive coating (11), and the conductive coating (11) is connected with negative high voltage of a high-voltage electrostatic generator (12) through a wire; gas flow valves (1) are respectively arranged on the inlet and the outlet of the micro booster pump (2).
2. The medical atomization device based on the multi-micro-pore array electrostatic atomization according to claim 1, wherein the dustproof filtering device is a dust filtering net (10) or an electric dust collector.
3. The medical atomization device based on the multi-micro-pore array electrostatic atomization according to claim 1, wherein the adjusting plate (8) is arranged at a vertical distance of 500 micrometers right below the outlet of the capillary tube (7); the ground plate (9) is arranged at a position which is 2 cm away from the right lower part of the adjusting plate (8).
4. A medical atomization device based on multi-micro-pore array electrostatic atomization according to claim 3, wherein the adjusting plate (8) and the ground plate (9) are made of copper plates.
5. The medical atomization device based on the multi-micro-pore array electrostatic atomization according to claim 4, wherein the capillary array is composed of a plurality of capillaries (7) perpendicular to the bottom surface of the liquid storage tank (5), and 8 symmetrically distributed grooves are formed on the outlet end surface of each capillary (7).
CN201911177954.9A 2019-11-27 2019-11-27 Medical atomizing device based on multi-micro-pore array electrostatic atomization Active CN110812628B (en)

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CN113289161B (en) * 2020-02-24 2023-08-01 深圳麦克韦尔科技有限公司 Medical atomizer and control method thereof
CN116059479A (en) * 2021-11-02 2023-05-05 深圳麦克韦尔科技有限公司 Electrospray atomization system

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