CN110812628A - Medical atomizing device based on multi-micron-hole array electrostatic atomization - Google Patents

Abstract

The invention discloses a medical atomization device based on multi-micron hole array electrostatic atomization. A liquid storage tank is axially arranged in a gas-liquid mixing chamber, and a micro booster pump is connected above the liquid storage tank. A capillary array is set at the bottom of the capillary, and the capillary array is connected to a negative high pressure. An adjustment plate and a ground plate are arranged in sequence below the capillary array. The adjustment plate and the ground plate are provided with holes corresponding to the capillaries one by one. After being charged, under the action of the high-voltage electric field between the adjustment plate and the ground plate, it is broken into sub-micron droplets. From the inhalation mask into the respiratory tract and lungs. The invention adopts the micro-nano processing method to prepare the ultra-fine water mist of a new type of micro-hole array electrostatic spray module to output stable atomization flow, has the advantages of small size, low noise, low cost and high stability, and can effectively improve the current medical atomization experience and performance. System reliability.

Description

A medical atomization device based on multi-micron hole array electrostatic atomization

technical field

The invention belongs to the field of medical atomization, and in particular relates to an electrostatic atomization drug delivery system for breaking droplets into microdroplets based on a multi-micron hole array.

Background technique

With the development of productivity and the improvement of medical level, atomization therapy, namely aerosol inhalation therapy, saves the pain of intravenous and intramuscular injection for special groups such as the old and the young, and has become the first choice for respiratory diseases and the most important means of bronchial purification treatment. The method uses an atomizing device to disperse the drug (solution or powder) into tiny droplets or particles, suspend it in the gas, and enter the respiratory tract and lungs to achieve local or systemic treatment.

There are many types and forms of current therapeutic nebulizers, and the uses of different nebulizers are determined by their respective design and working characteristics. Mechanical atomizers create mist through different mechanical means. For example, an ultrasonic atomizer uses the energy generated by ultrasonic vibration to vibrate a liquid into tiny droplets. However, due to the large atomized particles, most of the inhaled drug particles can only be deposited in the upper respiratory tract such as the mouth and throat, which cannot effectively treat lower respiratory tract diseases. The demand for liquid is large, causing waste; at the same time, there is also the phenomenon of rapid atomization, which is easy to cause hypoxia, choking, etc., so that the hospital basically stops using the atomizer. Most of the pneumatic nebulizers use the air suction effect (Bernoulli effect) as their basic working principle. When the high-speed airflow passes through the tiny opening of the liquid suction pipe, a negative pressure effect is generated around it, and the liquid required for treatment is sucked into the airflow. , and impact it into fine droplets suspended in it, forming an aerosol. Compared with ultrasonic nebulizers, this type of nebulizer can inhale a suitable amount of nebulizer within the same treatment time, and it is not easy to cause hypoxia and choking. The atomized particles are also finer, which can penetrate into the lower respiratory tract for treatment, and it is not easy to collide and combine, reducing the waste of liquid medicine. At present, the atomizers used in hospitals are basically this type. However, as people's demand for atomization increases, the shortcomings of air compression atomizers are becoming more and more prominent. The large size and loud noise can easily make infants and young children feel fearful and resist atomization; it is not easy to carry, requires an external power supply during work, and can only be used in hospitals or at home; the stability of the drug is affected, and the airflow is impacted, which is easy to increase the temperature, thereby affect drug stability.

Micro-mesh atomizers belong to a whole new generation of atomizers. The spray method is to use tiny ultrasonic vibration and mesh spray head structure to spray, through the high-frequency resonance of the ceramic atomizing sheet, the liquid water molecular structure is broken up to generate a natural and elegant ultra-fine water mist, and an efficient spray effect is achieved. Small size, low noise, easy to carry and use anytime, anywhere. However, this technology has a fatal disadvantage, because the micro-grid is composed of thousands of small holes with a diameter of 3 microns, which are easy to block after repeated use and cleaning, resulting in a decrease in the amount of mist or even no output. The durability of the mist filter is the greatest test.

SUMMARY OF THE INVENTION

Aiming at the technical problems existing in the atomizer in the prior art, the present invention proposes a medical atomization device based on electrostatic atomization of a multi-micron hole array, and adopts a micro-nano processing method to prepare a new type of micro-hole array electrostatic spray module. The spindle speed needs to be controlled to output ultra-fine water mist with stable atomization flow. It has the advantages of small size, low noise, low cost and high stability, which can effectively improve the current medical atomization experience and system reliability.

The technical scheme adopted in the present invention is as follows:

A medical atomization device based on multi-micron hole array electrostatic atomization, comprising a gas-liquid mixing chamber, a liquid storage tank is arranged in the gas-liquid mixing chamber along the axial direction, and a micro booster pump is connected above the liquid storage tank, The bottom of the liquid storage tank is provided with a capillary array, the capillary array is connected to the negative high pressure, an adjustment plate and a ground plate are arranged in sequence below the capillary array, and the adjustment plate and the ground plate are provided with holes corresponding to the capillaries one-to-one , and the adjusting plate is connected to the negative high pressure, and the ground plate is grounded; the bottom of the gas-liquid mixing chamber is connected to the inhalation mask through a gas-liquid conveying pipe.

Further, a dust-proof filter device is provided on the top of the gas-liquid mixing chamber;

Further, the dust filter is selected from a dust filter or an electrostatic precipitator. ;

Further, a downward micro axial flow fan is installed on the top of the gas-liquid mixing chamber;

Further, fixing between the liquid storage tank and the inner wall of the gas-liquid mixing chamber through a bracket;

Further, a conductive coating is sprayed on the outside of the bottom surface of the liquid storage tank, and the conductive coating is connected to the negative high voltage of the high-voltage electrostatic generator through wires, so that all capillaries are charged with negative high voltage.

Further, the adjustment plate is arranged at a vertical distance of 500 microns directly below the capillary outlet; the ground plate is arranged at a vertical distance of 2 cm directly below the adjustment plate.

Further, the adjustment plate and the ground plate are made of red copper plates.

Further, the capillary array is composed of a plurality of capillaries perpendicular to the bottom surface of the liquid storage tank, and eight symmetrically distributed grooves are opened on the outlet end face of each capillary.

Beneficial effects of the present invention:

1. The medical atomization device designed by the present invention establishes a drug delivery system based on the electrostatic atomization technology by studying various factors affecting the electrostatic spray jet, which has important innovative significance for promoting the development of the current medical atomization technology.

2. Compared with the third-generation micro-mesh nebulizer, the nebulizer designed in the present invention can achieve a more stable output of medicinal liquid on the basis of satisfying the excellent nebulization effect, muteness and portability, and is suitable for different dosages. For liquid medicine, electrostatic atomization has quite general applicability, and the reliability can also be well guaranteed.

3. In the present invention, by controlling the working conditions, the average diameter of the droplets generated by atomization can be controlled within 5 microns. Coupled with the array integration of the micro-spray unit, the atomization flow requirements of the same level of medical atomizers can be easily achieved. It is difficult to achieve by traditional atomization methods.

4. Compared with the commonly used pneumatic type atomizers on the market, the atomizer device designed in the present invention can have a relatively low cost by utilizing the principle of electrostatic atomization.

Description of drawings

1 is a schematic diagram of a medical atomization device based on multi-micron hole array electrostatic atomization of the present invention;

Fig. 2 is the schematic diagram of the micro-hole array electrostatic spray module in the present invention;

Fig. 3 is the bottom view of the micro-hole array of the present invention;

4 is an array layout diagram of holes on the adjustment plate and the ground electrode in the present invention;

Fig. 5 is the bottom view of the capillary end face in the present invention;

In the figure, 1. Gas flow valve, 2. Micro booster pump, 3. Voltage controller, 4. Micro axial flow fan, 5. Liquid storage tank, 6. Bracket, 7. Capillary tube, 8. Adjustment plate, 9. Ground plate, 10, dust filter, 11, conductive coating, 12, high voltage electrostatic generator, 13, gas-liquid mixing chamber, 14, inhalation mask, 15, gas-liquid delivery pipe.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

As shown in FIG. 1 , a medical atomization device based on electrostatic atomization of a multi-micron hole array includes a gas-liquid mixing chamber 13 , and a dust filter screen 10 and a downwardly arranged miniature dust filter screen 10 are installed at the top opening of the gas-liquid mixing chamber 13 . Axial flow fan 4; the dust filter 10 is removable and replaceable, and the dust filter 10 filters the air flowing into the air-liquid mixing chamber 13 from the outside, reducing the PM2.5 content, so that people can obtain cleaner air when inhaling, and avoid The liquid is contaminated and the probability of cross-infection is reduced.

A liquid storage tank 5 is installed in the gas-liquid mixing chamber 13 along the axial direction, and the liquid storage tank 5 is used to store the medicinal liquid; The liquid storage tank 5 and the inner wall of the gas-liquid mixing chamber 13 are fixed by the bracket 6. In this embodiment, the bracket 6 is made of insulating materials, such as nylon, etc. It is insulated from the gas-liquid mixing chamber 13 .

The top of the liquid storage tank 5 is connected to the outlet of the micro booster pump 2 through a gas pipeline, a gas flow valve 1 is installed on the inlet and outlet of the micro booster pump 2, and the power line of the micro booster pump 2 is connected to a voltage control The pressure inside the liquid storage tank 5 can be adjusted through the voltage controller 3 and the gas flow valve 1, so as to obtain a suitable atomization flow. 2, a capillary array is provided at the bottom of the liquid storage tank 5, and the capillary array is composed of a plurality of capillaries 7 perpendicular to the bottom surface of the liquid storage tank 5; and a conductive coating 11 is sprayed on the outside of the bottom surface of the liquid storage tank 5, such as Tin oxide, indium oxide; The conductive coating 11 is connected with the negative high voltage of the high-voltage electrostatic generator 12 through the wire, so that all capillary tubes 7 are brought with negative high voltage; The vertical distance below the outlet of the capillary tube 7 is set at 500 microns Adjustment plate 8, the ground plate 9 is set at a vertical distance of 2 cm below the adjustment plate 8, the adjustment plate 8 and the ground plate 9 are provided with holes corresponding to the capillary 7 one-to-one, and the adjustment plate 8 is connected to a negative high pressure The electrostatic generating device, the ground plate 9 is grounded; because each capillary 7 and the adjustment plate 8 have negative high voltage, there is a potential difference between the two, so that the atomized sub-micron droplets are not easy to be sucked to the end surface of the liquid storage tank 5. The amount of fog is reduced, and the voltage edge effect between adjacent capillaries 7 can be eliminated at the same time, so as to ensure the stability of the atomization of each capillary 7 . Then, a high-voltage electric field is formed between the adjustment plate 8 and the ground plate 9, so that the charged droplets are broken under the action of Coulomb repulsion; in this embodiment, the adjustment plate 8 and the ground plate 9 can be selected from copper plates, and the capillary 7 can be selected for use Stainless steel material, and the diameter of the capillary 7 is 300-400 microns.

As shown in Figure 5, there are 8 symmetrically distributed grooves on the outlet end face of the capillary 7. At the same time, the accuracy of the groove surface is ensured, so that the broken charged droplets are more likely to form multiple symmetrical jets, so that the atomized droplet particles are finer. Inhalation is better.

As shown in Figures 3 and 4, the array structure of the capillary 7 and the array structure of the holes on the adjustment plate 8 and the ground plate 9 all adopt an axisymmetric hexagonal layout, and the distance between adjacent capillaries 7 is 1 mm. This design can It is ensured that the multiple jets emitted by adjacent capillaries 7 do not interfere with each other, and at the same time, the integration density is maximized, which is beneficial to the control of the overall size of the device.

In order to explain the technical solution protected by the present invention more clearly, the following is further explained in conjunction with the working process: when the voltage controller 3 is powered on, the micro booster pump 2 pressurizes the liquid in the liquid storage tank 5, and the voltage controller 3 pressurizes the liquid in the liquid storage tank 5. The voltage at both ends of the micro booster pump 2 can be adjusted to adjust its power. By adjusting the opening of the valve 1, the air flow at the inlet and outlet of the micro booster pump can be adjusted; the micro booster pump 2 sends a certain pressure of air through the gas pipeline. Injected into the liquid storage tank 5; there is a pressure difference between the gas pressure in the liquid storage tank 5 and the external atmospheric pressure, and the medicinal liquid contained in the liquid storage tank 5 is discharged through the capillary array after the pressure difference. Since the conductive coating 11 at the bottom of the liquid storage tank 5 is connected to the negative high pressure, all the capillaries and the liquid medicine carry the negative high pressure.

After being charged, the liquid medicine extruded from the end face of the capillary array is broken into sub-micron droplets under the action of the high-voltage electric field between the adjustment plate 8 and the ground plate 9. Driven by the axial flow fan 4, the person enters the respiratory tract and the lungs from the inhalation mask 14 through the gas-liquid delivery pipe 15. At the same time, the airflow generated by the micro-axial flow fan 4 transports the sub-micron droplet group to the human respiratory tract and avoids the backflow of the droplet, so that the nylon bracket 6 is always kept dry and insulated.

To sum up, the medical atomization device designed by the present invention is compared with the micro-mesh atomizer in the prior art, and the micro-mesh of the micro-mesh atomizer is composed of thousands of small holes with a diameter of 3 microns. It is easy to be blocked after use and cleaning, resulting in a decrease in the amount of mist or even no output, while the electrostatic atomization of the multi-micron hole array used in the present invention can well avoid this problem, and can easily realize the mist of the same level of medical atomizer. flow demand. In addition, compared with SVN and other types of nebulizers commonly used in the market, nebulizers using the principle of electrostatic atomization can have a relatively low cost and excellent mute effect. Moreover, for different drug delivery liquids, electrostatic atomization has Quite general applicability, reliability can also be well guaranteed.

The above embodiments are only used to illustrate the design ideas and features of the present invention, and the purpose is to enable those skilled in the art to understand the contents of the present invention and implement them accordingly, and the protection scope of the present invention is not limited to the above embodiments. Therefore, all equivalent changes or modifications made according to the principles and design ideas disclosed in the present invention fall within the protection scope of the present invention.

Claims (9)

1. A medical atomization device based on multi-micron hole array electrostatic atomization, characterized in that it comprises a gas-liquid mixing chamber (13), and a liquid storage tank (5) is installed in the gas-liquid mixing chamber (13) along the axial direction. ), the top of the liquid storage tank (5) is connected to the micro booster pump (2), the bottom of the liquid storage tank (5) is provided with a capillary array, the capillary array is connected to a negative high pressure, and the adjustment is sequentially set below the capillary array The plate (8) and the ground plate (9), the adjustment plate (8) and the ground plate (9) are provided with holes corresponding to the capillaries (7) one-to-one, and the adjustment plate (8) is connected to the negative High pressure, the ground plate (9) is grounded; the bottom of the gas-liquid mixing chamber (13) is connected to the suction mask (14) through a gas-liquid delivery pipe (15). 2 . The medical atomization device based on electrostatic atomization of a multi-micron hole array according to claim 1 , wherein a dust filter device is provided on the top of the gas-liquid mixing chamber ( 13 ). 3 . 3 . The medical atomization device based on electrostatic atomization of a multi-micron hole array according to claim 2 , wherein the dust filter is selected from a dust filter screen ( 10 ) or an electrostatic precipitator. 4 . 4. A kind of medical atomization device based on multi-micron hole array electrostatic atomization according to claim 1, 2 or 3, characterized in that a downward micro shaft is installed on the top of the gas-liquid mixing chamber (13) flow fan (4). 5. A medical atomization device based on multi-micron hole array electrostatic atomization according to claim 4, wherein the liquid storage tank (5) and the gas-liquid mixing chamber (13) are connected by a bracket (6). ) between the inner walls. 6. A kind of medical atomization device based on multi-micron hole array electrostatic atomization according to claim 5, characterized in that, the outer side of the bottom surface of the liquid storage tank (5) is sprayed with a conductive coating (11), so The conductive coating (11) is connected to the negative high voltage of the high voltage electrostatic generator (12) through wires. 7. A kind of medical atomization device based on multi-micron hole array electrostatic atomization according to claim 6, characterized in that, the adjustment plate (8) is arranged at a vertical distance of 500 microns directly below the outlet of the capillary (7) ; The ground plate (9) is arranged at a vertical distance of 2 cm directly below the adjustment plate (8). 8 . The medical atomization device based on electrostatic atomization of a multi-micron hole array according to claim 7 , wherein the adjustment plate ( 8 ) and the ground plate ( 9 ) are made of red copper plates. 9 . 9. A medical atomization device based on electrostatic atomization of a multi-micron hole array according to claim 8, wherein the capillary array is composed of a plurality of capillaries (7) perpendicular to the bottom surface of the liquid storage tank (5). ), and there are 8 symmetrically distributed grooves on the outlet end face of each capillary (7).

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