CN110681058A - A pulsed light phototherapy device - Google Patents

Abstract

The invention belongs to the technical field of medical devices, in particular to a pulsed light phototherapy device. The device of the present invention includes a lighting module, a dimming module and a diffusion module; the lighting module is composed of one or more LED arrays to illuminate the phototherapy area; The dimming controls the constant current drive circuit of each LED light source to control the switch of the lighting module, adjust the power, brightness, duty cycle and frequency of the lighting module, so as to realize that the device emits a certain power and a certain duty to the phototherapy area. than the pulsed light. Compared with the existing LED phototherapy equipment, the present invention has great advantages: higher instantaneous output light energy for the target cells, so that the treatment effect is better; lower heat is generated for the phototherapy area, so as to avoid the user caused by serious heating Burns and improves user experience. The invention has broad application prospects.

Description

A pulsed light phototherapy device

technical field

The invention belongs to the technical field of medical devices, in particular to a phototherapy device.

Background technique

In the past ten years, light-emitting diodes (LEDs) have been increasingly used as light sources of phototherapy equipment in clinical and other medical fields by virtue of their own advantages. Alopecia, etc.), atrophy lines, and wound healing have achieved positive and satisfactory results. Phototherapy equipment is a device equipped with a suitable light source and related controls, which can achieve phototherapy by emitting light with a certain amount of energy on the phototherapy area of the human body, such as human skin, to achieve the effects of scar reduction, wound healing, and sleep improvement.

The current LED phototherapy equipment mainly includes low-power and medium-high power steady-state LED phototherapy equipment according to the power. The former is only suitable for target cells with low power requirements due to its low power. If the target cells or tissues are deep in the skin, the received light energy may be insufficient and the treatment effect may be affected. In the latter, by setting a higher light source power, the light source continuously emits high-energy light, and the high-energy light penetrates the skin and irradiates the target cells and tissues, thereby achieving the purpose of affecting its biological activity. However, due to the short distance between the light source of the phototherapy equipment and the phototherapy area, most of the light emitted by the light source reaches the phototherapy area, and the heat converted by the electrothermal of the light source is also transferred to the phototherapy area with the light, resulting in the generation of phototherapy area in a short time. The obvious heat sensation greatly reduces the user experience. When the fever is severe, it is very easy to cause burns to the user, and the excessively high temperature will also cause irreversible damage to the activity of cells and tissues, which is not conducive to the desalination of skin scars.

Therefore, there is an urgent need in the art for a phototherapy device capable of emitting light with sufficient energy and with no obvious heating effect, so as to achieve similar or even the same therapeutic effect and greatly improve the user experience. LED has the characteristics of high luminous efficiency, fast response speed, narrow spectrum, and combinable spectrum, etc. LED pulse light source with certain frequency and duty ratio can be obtained by PWM dimming or current dimming. Compared with steady-state LED light, pulsed light LED light sources emit light of the same energy in a shorter time and generate lower heat, which has the potential to solve the above problems.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a pulsed light phototherapy device with strong working stability and good therapeutic effect.

The pulsed light phototherapy device provided by the present invention includes an illumination module, a dimming module and a diffusion module; wherein, the illumination module is used to illuminate the phototherapy area; the dimming module is used to control the switch of the illumination module and the generation of pulsed light, Make the lighting module generate a higher instantaneous power (such as 50-100 times the rated power), and make the lighting module make full use of the non-pulse light working time for effective heat dissipation; the diffusion module is used to disperse the light emitted by the lighting module Divergence is performed so that the light covers the entire area of the phototherapy.

In the present invention, the lighting module is composed of one or more LED array light sources and a circuit substrate, the LED array light sources are arranged on the main surface of the circuit substrate, and the normal directions of the two coincide; wherein:

The LED array is a monochromatic LED light source, or a variety of monochromatic LED light sources with different peak wavelengths (LED peak wavelength types N>2);

The monochromatic LED light source has a central wavelength range of 200nm to 1000nm, and a full half-wave spectral width of less than 40nm;

The circuit substrate is used to provide working power for the LED light source;

The LED array light source emits light in a direction away from the main surface.

In the present invention, the pulsed light is specifically light with a duty cycle not higher than 50% and a frequency not lower than 20 Hz.

In the present invention, the dimming module adopts PWM dimming.

In the present invention, the dimming module performs independent constant current driving and PWM dimming for each LED array light source. in:

For the PWM dimming, the amplitude setting range is 1~5V, the frequency setting range is 20Hz~20kHz, and the duty cycle setting range is 0~100%. Preferably, the duty cycle is below 50%.

In the present invention, the diffusion module is disposed on the side facing the main surface of the circuit substrate, and is used for diffusing the incident light, so as to increase the divergence angle range of the light emitted by the LED array light source.

Optionally, the diffusion module is specifically a diffusion plate.

The beneficial effects of the present invention are:

1. The pulsed light phototherapy device proposed by the present invention can achieve the same phototherapy effect as the steady-state light LED phototherapy device. Therefore, this device can replace the steady-state phototherapy device to perform phototherapy on patients;

2. The device has strong working stability, and has higher instantaneous power than low-power steady-state LED phototherapy devices, which can transmit greater instantaneous energy to target cells or tissues, activate cell activity, and make the treatment effect better;

3. The working stability of this device is strong. In the same working time, the heat generation is lower than that of medium and high power steady-state LED phototherapy equipment, which avoids user burns caused by serious heat and improves user experience;

4. The device is fully controllable, and can set the required wavelength, duty cycle, frequency and wavelength of pulsed light and working time to illuminate the phototherapy area according to the specific conditions of the phototherapy area.

Description of drawings

FIG. 1 is a schematic diagram of the system of the present invention.

FIG. 2 is a schematic diagram of an apparatus according to an embodiment of the present invention.

FIG. 3 is a comparison between the phototherapy effect of the embodiment of the present invention and the low-power steady-state LED phototherapy device.

FIG. 4 is a comparison between the phototherapy effect of the embodiment of the present invention and the medium and high power steady-state LED phototherapy device.

Reference numerals in the figure: 1 is a lighting module, 2 is a dimming module, 3 is a diffusion module, 4 is a circuit substrate, 5 is an LED array light source, 6 is a circuit substrate, 7 is a PWM dimming unit, and 8 is a control panel.

Detailed ways

The technical solutions of the present invention will be further described below with reference to the embodiments and the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the protection scope of the present invention.

The thickness of the current phototherapy equipment is getting thinner and thinner, which makes it difficult to dissipate the heat generated by the light source in the phototherapy equipment. When the phototherapy device works at a constant power for a certain period of time, the heat is transferred to the phototherapy area along with the light emitted by the light source. Therefore, in the phototherapy area, it is easy to cause a burning sensation to the user due to excessive heat that is difficult to dissipate. Especially wearable light therapy devices that use LEDs as light sources.

An embodiment of the present invention provides a pulsed light phototherapy device, which includes a lighting module 1 , a dimming module 2 and a diffusion module 3 , as shown in FIGS. 1 and 2 . The lighting module 1 is used to illuminate the phototherapy area. The dimming module 2 is used to control the switching of the lighting module 1 and the generation of pulsed light. The diffusing module 3 is used for diffusing the light emitted by the lighting module 1, so that the light covers the whole area of the phototherapy.

The lighting module 1 is composed of a circuit substrate 4 and an LED array light source 5 , and the circuit substrate 4 is used to transmit a working signal to the LED array light source 5 . The LED array light source 5 is provided on the main surface of the circuit board 4, and the normal directions of the two are coincident. The back of the circuit substrate 4 is affixed with thermally conductive silica gel and a heat sink. The LED array light source 5 is a monochromatic LED light source or a variety of monochromatic LED light sources with different peak wavelengths (LED peak wavelength types N>2). The peak wavelength range is 200nm~1000nm, and the full width at half-wave of the spectrum is less than 40nm. The LED array light source 5 receives the working signal from the dimming module 2 through the circuit substrate 4 and emits pulsed light. Pulse light is monochromatic light with certain working time, peak wavelength, duty cycle and frequency.

The dimming module 2 is composed of a circuit substrate 6 , a PWM dimming unit 7 and a control panel 8 . The circuit board 6 is soldered with electrical paths, which are not only used to provide working power for the LED array light source 5, PWM dimming unit 7 and control panel 8 of the lighting module 1, but also responsible for signal transmission, including the control panel 8 and the dimming unit 7. Signal transmission between lighting module 1 and dimming module 2. The dimming module 2 controls the lighting module 1 , specifically, performs independent constant current driving on each LED array light source 5 in the lighting module 1 , and simultaneously transmits a PWM signal to each LED array light source 5 . The amplitude range of the PWM signal that can be output by the dimming module 2 is 1~5V, the PWM frequency range is 20Hz~20kHz, and the duty cycle range is 0~100%. The control panel 8 is fixed on the circuit board 6 of the dimming module 2 , coincides with the normal direction of the circuit board 6 , and penetrates the diffusion module 3 . The side of the control panel faces outward and is on the same level as the face of the diffusion module 3 facing outward. The control panel 8 is used to set phototherapy parameters for the user, specifically, the settings of peak wavelength, duty cycle, frequency and working time. The set parameters, including peak wavelength, duty cycle, frequency and working time, are all transmitted to the PWM dimming unit 7 through the circuit substrate 6 . After the dimming unit 7 processes the parameter information, it sends out a new signal and transmits it to the LED array light source 5 of the lighting module 1 again through the electrical path of the circuit substrate 6, so that the LED array light source 5 emits a specific working time, a specific peak wavelength, and a specific occupation time. Empty ratio and pulsed light of a specific frequency.

The diffusion module 3 is disposed on the side toward which the main surface of the circuit substrate 4 faces, and is a plate that interferes with the incident light, so as to diffuse the light. The light emitted by the LED array light source 5 enters the diffusion module 3, which interferes with the light and expands the angle range of the light from the original 120° to more than 160°, so as to refract the light emitted by the lighting module 1 into the phototherapy. All areas. The materials of the diffusion module 3 are common glass and polycarbonate (PC), and other materials can also be selected.

Example 1, phototherapy is performed on stretch marks on the abdomen, and the corresponding target cells are fibroblasts. Fibroblasts have a certain active reproductive capacity, and repair the damaged connective tissue in the dermis by synthesizing elastic fibers and collagen. Therefore, it can improve stretch marks by activating fibroblasts. The viability of fibroblasts is positively correlated with the received light energy, and when the light energy exceeds a certain threshold, the activity will be inhibited. Assuming that the effective phototherapy band is light with a peak wavelength of 630nm and a wavelength band of 40nm, the minimum threshold W1 of the effective energy of phototherapy is 50J, and assuming that the luminous efficiency of the LED light source is 50%, that is, 50% of the energy is converted into heat, and W2 is 50J. The total energy W of the LED light source is 100J.

On the one hand, a comparison with a low-power steady-state light LED phototherapy device is shown in Figure 3. Assuming that the power P1 of the low-power LED phototherapy device is 10 mW, the average power P2 of the pulsed light phototherapy device of the present invention is also 10 mW. In order to achieve the W1 value, both the working time T1 and T2 are 166.7 minutes, and the heat generation is the same. The difference is that the pulsed light LED phototherapy device of the present invention has the flexibility of instantaneous power, the peak voltage can be set to 3V, the current is constant to 111mA, and the duty cycle is 30%. At this time, the average power was still 10mW, but the instantaneous power P2' reached 33.3mW, and the instantaneous energy received by the fibroblasts was 3.3 times that of the low-power LED phototherapy device, an increase of 133%. Therefore, the pulsed phototherapy device of the present invention has a higher activation ability to target cells than the low-power LED phototherapy device, and the expected therapeutic effect is better, which has certain advantages.

On the other hand, compared with the medium and high power steady-state light LED phototherapy device, as shown in Figure 4. Assuming that the power P3 of the medium and high power LED phototherapy equipment is 30mW, the average power P2 of the pulsed light phototherapy equipment of the present invention is 25mW, the instantaneous power P2' is set to 30mW, and the duty cycle is 83%. In order to achieve the W1 value, the working time T3 of the former is 55.6 minutes, and the heat generated per unit time is 0.015J/s. The pulsed light therapy equipment of the present invention has a working time T2' of 66.7 minutes, and the heat generated per unit time is 0.0125J/s, which is only 83% of the former, and reduces the heat by 17%. It is explained that the pulsed light therapy device of the present invention generates lower heat than the medium and high power steady-state LED phototherapy device during the treatment, which can effectively avoid the user's burning sensation and reduce the risk of burns.

Although the three phototherapy devices can meet the treatment requirements of the target light energy, the low or high power of the steady-state light LED phototherapy device will cause different problems. Combining the above examples, it can be seen that the pulsed light phototherapy device of the present invention has the flexibility of instantaneous power setting and the effect of low heat generation.

Embodiment 2, the device of the present invention is suitable for adjuvant therapy of chronic autoimmune thyroiditis. With the use of hormone drugs, it can alleviate the further aggravation of autoimmune thyroiditis, enhance cellular immunity, and improve thyroid hormone activity. Existing studies have shown that when patients take medication, the need for levothyroxine doses after photobiostimulation therapy is reduced, the level of TPOAb is reduced, and the echogenicity of the ultrasound parenchyma is significantly increased. It shows that photobiostimulation has certain auxiliary curative effect.

In this case, levothyroxine is used as the hormone drug, which is medically prescribed. The LED array light source 5 selects infrared LEDs with a peak wavelength of 780 nm. Set the dimming module 2: the amplitude is 5V, the current is 1A, the frequency is 5kHz, and the average output power is 250mW. During the drug treatment period, the device of the present invention was used to perform phototherapy on the thyroiditis for 4 minutes/time, and the treatment period was 30 days, twice a week. The dose of light can be adjusted as needed, with a range of 38-108J/cm^2. In this example, 60J/cm^2 is selected, so the duty cycle of the dimming module 2 is 5%. Ultrasonography was used before and after phototherapy, and the echoes were quantified by gray-scale histograms. In addition, thyroid function and thyroid autoantibodies were also evaluated before and after phototherapy, such as triiodothyronine, thyroxine (T4), thyrotropin, and thyroid peroxidase (TPOAb).

Example 3, the device of the present invention is suitable for the treatment of chronic treatment-resistant psoriasis. Psoriasis is a chronic autoimmune skin disease caused by an abnormal overgrowth of keratinocytes, an abnormal proliferation that occurs in the dermis. Photobiostimulation therapy has been shown to have anti-inflammatory effects, so the device of the present invention can be used to treat refractory psoriasis. In this example, the device of the present invention was fixed at a distance of 1 cm from the affected area. The LED array light source 5 adopts two types, and the peak wavelengths are respectively 630nm red LED and 830nm near-infrared LED. The two array light sources 5 are integrated on the circuit substrate 4 of the lighting module 1 and can be independently set through the dimming module 2 . Set the dimming module 2: the frequency is 5kHz, and the average output power is 250mW. The device of the present invention is used to perform phototherapy for 20 minutes/time on the affected part of psoriasis, the treatment period is 28 days, and phototherapy is performed every 3 days. Adjust the duty cycle so that the illumination dose of the red LED is 126J/cm^2, and the illumination dose of the near-infrared LED is 60J/cm^2. After each phototherapy session, instruct the patient to apply an over-the-counter ointment to the affected area to keep the skin moist. Patients were randomly visited within 3 to 8 months after the end of the entire treatment cycle to observe the inflammation of the skin, including the area of inflammation, skin pain and other side effects. Preliminary research results show that the clearance rate of psoriasis is greater than 60%, and the satisfaction rate is generally high.

Embodiment 4, the device of the present invention is suitable for the treatment of arthritis. Common arthritis is osteoarthritis and rheumatoid arthritis. The former produces inflammation due to bone hyperplasia, while the latter produces autoimmune inflammation due to synovitis. Similar to the above examples, the device of the present invention has a certain anti-inflammatory effect through photobiostimulation. In this example, to perform phototherapy on the synovium or cartilage, an LED with a wavelength range covering 810 nm is selected as the LED array light source 5 . Then set the dimming module 2: the average power is 224mW, the frequency is 5kHz, 6 minutes/time, the illumination dose is about 40.32J/cm^2, and the illumination is performed every three days, and the illumination period is 80 days. Knee motion, tenderness, pain, and stiffness were evaluated before and after phototherapy during and 6 months after phototherapy.

Embodiment 5, the device of the present invention can also be used to reduce delayed onset muscle soreness and improve muscle damage after strenuous exercise, especially for athletes with a fixed exercise plan and a large amount of exercise, since phototherapy requires a certain time, the device of the present invention is very suitable for gradual Athletes with increased physical activity and limited rest periods. The LED array light source 5 may still use LEDs with a wavelength covering 850nm, and the dimming module 2 is set to: the average power is 312.5mW, the illumination time is 4 minutes/time, and the illumination dose is 75J/cm^2. Frequency and duty cycle can be adjusted according to phototherapy effect. Light 3 times a week for week 12. When the user performs strenuous exercise, such as light exposure immediately after strength training, the gene expression, muscle condition before and after training is evaluated through muscle biopsy, magnetic resonance imaging, maximum load and anti-fatigue tests. Creatine kinase levels can also be measured during training to assess muscle damage and delayed-onset muscle soreness. The results show that, compared with placebo, effective phototherapy with the device of the present invention can inhibit the amount of a marker protein of inflammation, namely interleukin 1β, and also reduce the amount of marker protein of muscle atrophy, increase the user's exercise load, and reduce the amount of muscle atrophy. fatigue.

Claims (8)

1. A pulsed light phototherapy device, comprising a lighting module, a dimming module and a diffusion module; wherein the lighting module is used to illuminate a phototherapy area; the dimming module is used to control the switch and pulse of the lighting module The generation of light enables the lighting module to generate instantaneous power that is 50-100 times the rated power, and enables the lighting module to make full use of the non-pulse light working time for effective heat dissipation; the diffusion module is used to diffuse the light emitted by the lighting module , so that the light covers the entire area of the phototherapy. 2 . The pulsed light phototherapy device according to claim 1 , wherein the lighting module is composed of one or more LED array light sources and a circuit substrate, and the LED array light sources are arranged on the main surface of the circuit substrate. 3 . On the above, the normal directions of the two coincide; the circuit substrate is used to provide working power for the LED light source. 3. The pulsed light phototherapy device according to claim 2, wherein the LED array is a monochromatic LED light source, or a variety of monochromatic LED light sources with different peak wavelengths, and the LED peak wavelength types are N>2; wherein : The single-color LED light source has a central wavelength range of 200nm to 1000nm, and a full half-wave spectral width of less than 40nm; The LED array light source emits light in a direction away from the main surface. 4. The pulsed light phototherapy device according to claim 2, wherein the dimming module performs independent constant current driving and PWM dimming on each LED array light source; wherein: For the PWM dimming, the amplitude setting range is 1~5V, the frequency setting range is 20Hz~20kHz, and the duty cycle setting range is 0~100%. 5 . The pulsed light phototherapy device according to claim 2 , wherein the diffusion module is arranged on the side toward which the main surface of the circuit substrate faces, and is used for diffusing the incident light, so that the LED The divergence angle range of the light emitted by the array light source is increased. 6. The pulsed light phototherapy device according to claim 1, wherein the dimming module is composed of a circuit substrate, a PWM dimming unit and a control panel; The LED array light source, PWM dimming unit and control panel provide working power and are used for signal transmission, including signal transmission between the control panel and the dimming unit, and signal transmission between the lighting module and the dimming module. 7 . The pulsed light phototherapy device according to claim 6 , wherein the dimming module controls the lighting module, specifically: performing independent constant current driving on each LED array light source in the lighting module, The LED array light source transmits the PWM signal; the amplitude range of the PWM signal output by the dimming module is 1~5V, the PWM frequency range is 20Hz~20kHz, and the duty cycle range is 0~100%; the control panel is fixed on the circuit of the dimming module On the substrate, it coincides with the normal direction of the circuit substrate, and runs through the diffusion module; the side of the control panel faces outward, and is on the same horizontal plane as the face of the diffusion module; the control panel is used to set phototherapy parameters for the user, the phototherapy The parameters are, peak wavelength, duty cycle, frequency and working time; the set parameters are transmitted to the PWM dimming unit through the circuit substrate; after the dimming unit processes the parameter information, a new signal is sent through the circuit substrate again. The channel is transmitted to the LED array light source of the lighting module, so that the LED array light source emits pulsed light with a specific working time, a specific peak wavelength, a specific duty cycle and a specific frequency. 8 . The pulsed light phototherapy device according to claim 1 , wherein the diffusion module is a plate that interferes with the incident light to diffuse the light; the light emitted by the LED array light source enters the In the diffusion module, the diffusion module interferes with the light, and expands the angle range of the light from the original 120° to more than 160°.

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