CN110507581A - A kind of oil control and acne removal preparation of plant origin and its application in cosmetics - Google Patents
A kind of oil control and acne removal preparation of plant origin and its application in cosmetics Download PDFInfo
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- CN110507581A CN110507581A CN201910896267.6A CN201910896267A CN110507581A CN 110507581 A CN110507581 A CN 110507581A CN 201910896267 A CN201910896267 A CN 201910896267A CN 110507581 A CN110507581 A CN 110507581A
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- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 46
- 238000002360 preparation method Methods 0.000 title claims abstract description 46
- 239000002537 cosmetic Substances 0.000 title abstract description 11
- 239000000284 extract Substances 0.000 claims abstract description 36
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- 241000957095 Spiraea alba Species 0.000 claims description 17
- 238000002386 leaching Methods 0.000 claims description 16
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- 238000001914 filtration Methods 0.000 claims description 10
- 239000007788 liquid Substances 0.000 claims description 9
- 239000004744 fabric Substances 0.000 claims description 8
- 239000000706 filtrate Substances 0.000 claims description 8
- 230000008439 repair process Effects 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 5
- 241000026010 Dendrobium candidum Species 0.000 claims description 4
- 238000012545 processing Methods 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 3
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- 235000017617 Lonicera japonica Nutrition 0.000 claims description 2
- 241001570521 Lonicera periclymenum Species 0.000 claims description 2
- 244000182022 Salvia sclarea Species 0.000 claims description 2
- 235000002911 Salvia sclarea Nutrition 0.000 claims description 2
- 239000001691 salvia sclarea Substances 0.000 claims description 2
- 238000012360 testing method Methods 0.000 abstract description 18
- 241000186427 Cutibacterium acnes Species 0.000 abstract description 9
- 229940055019 propionibacterium acne Drugs 0.000 abstract description 9
- 210000002374 sebum Anatomy 0.000 abstract description 8
- 230000028327 secretion Effects 0.000 abstract description 7
- 230000003255 anti-acne Effects 0.000 abstract description 4
- 230000003463 hyperproliferative effect Effects 0.000 abstract description 4
- 206010033733 Papule Diseases 0.000 abstract description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of oil control and acne removal preparation of plant origin and its applications in cosmetics.The oil control and acne removal preparation is spent by corn poppy, meadow sweet, river radix paeoniae rubra, which extracts, to be made, the preparation process of the oil control and acne removal preparation uses the active constituent in microwave abstracting quick release plant cell, using the unwanted macromolecular polysaccharide of ethanol precipitation, protein, then solvent is removed using rotary evaporation, obtained oil control and acne removal better stability of preparation, it can long term storage, rich in active components of plants, test proves, it can effectively inhibit sebum excessive secretion, inhibit propionibacterium acnes hyper-proliferative, good anti-acne can be played the role of in cosmetics series by applying, especially closed comedones, inflamed papules, useless fellow etc. is significant in efficacy.
Description
Technical field
The present invention relates to cosmetic fields, and in particular to the oil control and acne removal preparation of a kind of plant origin and its in cosmetics
Application.
Background technique
Whelk, also known as acne are a kind of dermatology's common chronic diseases for betiding hair follicle sebum, mostly occur in face,
The sebaceous glands such as neck position abundant.Modern medicine believes that, the morbidity of acne mainly increases with androgen, sebum secretion, hair follicle
The factors such as hyperfunction, the propionibacterium acnes proliferation of mouth epithelium angling are related.It is anti-that propionibacterium acnes participate in inflammation in pathogenesis of acne
It should be embodied in: firstly, generating a large amount of free fatty acid, free-fat by the triglycerides in release lipase degradation skin
Nonspecific inflammation reaction occurs for sour hair follicle stimulating and perifollicolar, and generates a large amount of proinflammatory inflammation factors;Secondly, acne propionic acid
Bacillus can induced monocyte and keratinocyte secretion interleukin-1 (IL-1), cachectin (TNF-α), Bai Jie
Element -8(IL-8) etc. cell factors, these cell factors can cause inflammation damnification with chemotactic inflammatory cell to perifollicolar;Again
Secondary, propionibacterium acnes can also promote the activation of Toll-like receptor in monocyte (TLRs), trigger cytokine release, aggravation
The inflammatory reaction of acne is (referring to king's Yue, Guo Miaomiao, Shi Yanqin, Pan Xianhua, Lu Yanhua, the anti-inflammatory anti-acne of Cao Ping Pogostemon cablin essential
Efficacy study [J] daily chemical industry, 2017,47 (05): 272-276.).
Therefore, inhibit sebum excessive secretion, inhibit propionibacterium acnes hyper-proliferative to be the key that removing acne.
Summary of the invention
The object of the present invention is to provide a kind of oil control and acne removal preparations, can effectively inhibit sebum excessive secretion, inhibit acne third
Acidfast bacilli hyper-proliferative, good oil control and acne removal effect can be played in cosmetics by applying.
A kind of oil control and acne removal preparation, is made by the component of following parts by weight: corn poppy spends 1-5 parts, 5-10 parts of meadow sweet, river
1-5 parts of radix paeoniae rubra.
In wherein some embodiments, the oil control and acne removal preparation is made by the component of following parts by weight: corn poppy spends 2
Part, 8 parts of meadow sweet, 1 part of river radix paeoniae rubra.
The embodiment of the invention also provides the preparation methods of the oil control and acne removal preparation, include the following steps:
(1) corn poppy is spent, the complete stool crushing of the complete stool of meadow sweet, river radix paeoniae rubra, obtains plant powder；It is soaked in water；It opens micro-
Wave processing, is cooled to room temperature, and obtains leaching liquor；
(2) leaching liquor is centrifuged, takes supernatant；Ethanol solution is added, stirs evenly；It is filtered after standing, takes filtrate, Rotary Evaporators subtract
Pressure concentration, obtains medicinal extract；By medicinal extract with water redissolve to get.
In wherein some embodiments, the additive amount of water described in step (1) is 10-20 times of plant powder weight, is used
Water-soaking time is 1-5 hours；
In wherein some embodiments, the power of microwave described in step (1) is 400W, and the processing time of the microwave is 10-
30 minutes；
In wherein some embodiments, the volumetric concentration of ethanol solution described in step (2) is 95%, and the ethanol solution adds
Dosage is 3-5 times of supernatant weight；
In wherein some embodiments, time of repose is 6-12 hours in step (2), and the filtering is filtered using 100-1000 mesh
Cloth filtering, the dosage of water is 10-20 times of medicinal extract weight when the redissolution.
The embodiment of the invention also provides one kind to repair skin essence liquid, the component including following mass percentage:
。
In wherein some embodiments, the component repaired skin essence liquid and also contain following mass percentage:
Dendrobium candidum (DENDROBIUM CANDIDUM) extract 0.1-1%,
Ou Dancan (SALVIA SCLAREA) extract 0.1-1%,
Honeysuckle (LONICERA JAPONICA) flower extract 0.1-1%.
Technical solution provided in an embodiment of the present invention has the benefit that
Selected corn poppy (PAPAVER RHOEAS) flower extract of the present invention, meadow sweet (SPIRAEA SALICIFOLIA) are extracted
Object, river radix paeoniae rubra (PAEONIA VEITCHII) extract, have been made a kind of oil control and acne removal preparation, the oil control and acne removal preparation
Preparation process uses the active constituent in microwave abstracting quick release plant cell, using the unwanted macromolecular of ethanol precipitation
Polysaccharide, protein, then using rotary evaporation remove solvent, obtained oil control and acne removal better stability of preparation, can long term storage,
Rich in active components of plants, test is proved, can effectively be inhibited sebum excessive secretion, be inhibited propionibacterium acnes hyper-proliferative,
The curative effects such as good anti-acne, especially closed comedones, inflamed papules, useless fellow can be played the role of in cosmetics series by, which applying, shows
It writes.
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, embodiment of the present invention will be made into one below
Step ground detailed description, embodiments of the present invention are not limited thereto, for not specifically specified technological parameter or condition, can refer to
Routine techniques carries out.
The cosmetic standard Chinese name for the extract that the corn poppy of the present invention being related to spends are as follows: corn poppy (PAPAVER
RHOEAS) flower extract；The cosmetics Chinese name of the extract of related meadow sweet complete stool are as follows: meadow sweet (SPIRAEA
SALICIFOLIA) extract；The cosmetics Chinese name of the extract of related river radix paeoniae rubra complete stool are as follows: river radix paeoniae rubra (PAEONIA
VEITCHII) extract.
Embodiment 1
A kind of oil control and acne removal preparation, is made by the component of following parts by weight: corn poppy spends 1 part, 10 parts of meadow sweet, 1 part of river radix paeoniae rubra.
The preparation method of the oil control and acne removal preparation, includes the following steps:
(1) corn poppy is spent, the complete stool mixing of the complete stool of meadow sweet, river radix paeoniae rubra, crushes, obtains plant powder；Plant Powder is added
The water of 20 times of last weight impregnates 1 hour；It opens the microwave generator that power is 400W to handle 30 minutes, is cooled to room temperature, obtains
Leaching liquor；
(2) leaching liquor is centrifuged, takes supernatant；Addition volumetric concentration is 95% ethanol solution, wherein the addition of the ethanol solution
Amount is 3 times of supernatant weight, is stirred evenly；100 mesh filter-cloth filterings after standing 12 hours take filtrate, and Rotary Evaporators are concentrated under reduced pressure,
Obtain medicinal extract；With the water of 20 times of medicinal extract weight redissolve to get.
Embodiment 2
A kind of oil control and acne removal preparation, is made by the component of following parts by weight: corn poppy spends 5 parts, 5 parts of meadow sweet, 5 parts of river radix paeoniae rubra.
The preparation method of the oil control and acne removal preparation, includes the following steps:
(1) corn poppy is spent, the complete stool mixing of the complete stool of meadow sweet, river radix paeoniae rubra, crushes, obtains plant powder；Plant Powder is added
The water of 10 times of last weight impregnates 5 hours；It opens the microwave generator that power is 400W to handle 10 minutes, is cooled to room temperature, obtains
Leaching liquor；
(2) leaching liquor is centrifuged, takes supernatant；Addition volumetric concentration is 95% ethanol solution, wherein the addition of the ethanol solution
Amount is 5 times of supernatant weight, is stirred evenly；1000 mesh filter-cloth filterings after standing 6 hours take filtrate, and Rotary Evaporators are concentrated under reduced pressure,
Obtain medicinal extract；With the water of 10 times of medicinal extract weight redissolve to get.
Embodiment 3
A kind of oil control and acne removal preparation, is made by the component of following parts by weight: corn poppy spends 2 parts, 8 parts of meadow sweet, 1 part of river radix paeoniae rubra.
The preparation method of the oil control and acne removal preparation, includes the following steps:
(1) corn poppy is spent, the complete stool mixing of the complete stool of meadow sweet, river radix paeoniae rubra, crushes, obtains plant powder；Plant Powder is added
The water of 15 times of last weight impregnates 3 hours；It opens the microwave generator that power is 400W to handle 20 minutes, is cooled to room temperature, obtains
Leaching liquor；
(2) leaching liquor is centrifuged, takes supernatant；Addition volumetric concentration is 95% ethanol solution, wherein the addition of the ethanol solution
Amount is 4 times of supernatant weight, is stirred evenly；800 mesh filter-cloth filterings after standing 10 hours take filtrate, and Rotary Evaporators are concentrated under reduced pressure,
Obtain medicinal extract；With the water of 15 times of medicinal extract weight redissolve to get.
Comparative example 1
A kind of preparation method of oil control and acne removal preparation, includes the following steps:
(1) corn poppy's pollen is broken, obtain plant powder；15 times of plant powder weight of water is added, impregnates 3 hours；Open function
The microwave generator that rate is 400W is handled 20 minutes, is cooled to room temperature, and leaching liquor is obtained；
(2) leaching liquor is centrifuged, takes supernatant；Addition volumetric concentration is 95% ethanol solution, wherein the addition of the ethanol solution
Amount is 4 times of supernatant weight, is stirred evenly；800 mesh filter-cloth filterings after standing 10 hours take filtrate, and Rotary Evaporators are concentrated under reduced pressure,
Obtain medicinal extract；With the water of 15 times of medicinal extract weight redissolve to get.
Comparative example 2
A kind of preparation method of oil control and acne removal preparation, includes the following steps:
(1) complete stool of meadow sweet is crushed, obtains plant powder；15 times of plant powder weight of water is added, impregnates 3 hours；It opens
It opens the microwave generator that power is 400W to handle 20 minutes, is cooled to room temperature, obtains leaching liquor；
(2) leaching liquor is centrifuged, takes supernatant；Addition volumetric concentration is 95% ethanol solution, wherein the addition of the ethanol solution
Amount is 4 times of supernatant weight, is stirred evenly；800 mesh filter-cloth filterings after standing 10 hours take filtrate, and Rotary Evaporators are concentrated under reduced pressure,
Obtain medicinal extract；With the water of 15 times of medicinal extract weight redissolve to get.
Comparative example 3
A kind of preparation method of oil control and acne removal preparation, includes the following steps:
(1) complete stool of river radix paeoniae rubra is crushed, obtains plant powder；15 times of plant powder weight of water is added, impregnates 3 hours；It opens
It opens the microwave generator that power is 400W to handle 20 minutes, is cooled to room temperature, obtains leaching liquor；
(2) leaching liquor is centrifuged, takes supernatant；Addition volumetric concentration is 95% ethanol solution, wherein the addition of the ethanol solution
Amount is 4 times of supernatant weight, is stirred evenly；800 mesh filter-cloth filterings after standing 10 hours take filtrate, and Rotary Evaporators are concentrated under reduced pressure,
Obtain medicinal extract；With the water of 15 times of medicinal extract weight redissolve to get.
Test 1 inhibits the test of sebum excessive secretion
Golden Hamster flank Flank organs are androgen target organs, include a large amount of sebum glandular structures, to the anti-of androgen stimulation
Ying Shangyu people is similar, is the ideal animals model of current research drug antiandrogen and anti-sebum gland proliferative activity.
Oil control and acne removal preparation obtained by embodiment 1-3 and comparative example 1-3 is tested, and blank control group is set.
Test method: the healthy male golden yellow gopher 70 of selection, totally 7 groups, every group 10.Medicine-feeding way: gastric infusion;
Dosage: blank control group gives distilled water;Other test groups give 3g/kg respectively.Administration frequency: 1 day primary, even
Continuous administration 30 days.The chaeta on the right side of suslik back is rejected before experiment, exposure Flank organs use vernier caliper under strong illumination
Measure the maximum transverse diameter (DT value) of sebaceous glands patch and maximum vertical diameter (DL), before record administration with data after the last administration.Using
19.0 software of SPSS is for statistical analysis to data, and measurement data is indicated using x ± s, and the comparison between group is examined using t.Specifically
Data are shown in Table 1.
(x ± s) is compared in the Flank organs variation of 1 each group of table test front and back right side
。
Test result table 1 is shown, before administration, oil control and acne removal preparation, blank obtained by embodiment 1-3 and comparative example 1-3
For totally 7 groups of Flank organs sizes through variance test, difference is not statistically significant (P > 0.05) for control group, is comparable.Administration
Afterwards, the ipsilateral Flank organs area of embodiment 1-3 is obviously reduced before being relatively administered, and difference is with statistical significance (P <
0.05).The ipsilateral Flank organs area of comparative example 1-3 is slightly reduced before being relatively administered, and no significant difference (P > 0.05).
The ipsilateral Flank organs area of blank control group relatively be administered before slightly increase, it is expected to be raising below product increase caused by, and difference without
Statistical significance (P > 0.05).It can be seen that corn poppy (PAPAVER RHOEAS) flower extract, meadow sweet (SPIRAEA
SALICIFOLIA oil-control effect is best when) extract, river radix paeoniae rubra (PAEONIA VEITCHII) extract share.
Test 2 inhibits propionibacterium acnes test
Oil control and acne removal preparation obtained by embodiment 1-3 is tested, one test plate of each test group.It will be activated
Propionibacterium acnes are configured to bacteria suspension (4*106CFU/mL), take 0.1mL to be applied on cooked meat medium plate and place 30 points
Then clock sticks in each plate and puts 4 Oxford cups, each Oxford cup instills 100 microlitres of samples to be tested.It is placed in 36 DEG C of biochemical trainings
It supports and is inverted culture 7 days in case, measure the diameter of inhibition zone, calculate average value.Specific data are shown in Table 2.
2 inhibition zone test of table
As seen from Table 2, oil control and acne removal preparation obtained by 1-3 of the embodiment of the present invention has good inhibition to propionibacterium acnes
Effect.
Embodiment 4
。
One kind repairing skin essence liquid, the component including following mass percentage:
It is above-mentioned repair skin essence liquid the preparation method is as follows:
(1) A phase is put into emulsion pot, is heated to 85 DEG C, stirring and dissolving is uniform；B phase is put into oily phase pot, is dissolved by heating equal
It is even, oil phase is made.
(2) it is mutually pumped into emulsion pot, opens 3000rpm homogenization 5 minutes by oily under stiring；Insulated and stirred at 85 DEG C
30 minutes；
(3) C phase is added, stirs evenly；48 DEG C are cooled to, D phase is added, stirs evenly；It discharges after the assay was approved.
Test the assessment of 3 volunteer's effects
Effect assessment is carried out to skin essence liquid tissue volunteer is repaired obtained by embodiment 4.
Test method: convening 75 Oilys and the volunteer with whelk, is divided into 5 groups, every group of 15 people are early daily
Late respectively to repair skin essence liquid using primary, usage amount is 0.1g/ times, is applied on the face, is gently massaged into absorption, is used continuously 4 weeks.
Photographing to record anti-acne situation, (by comparing with the photo before product is used, the judgement that whelk quantity reduces 80% or more is to have
Effect), and with Sebumeter SM815 skin oil and fat tester measure volunteer's forehead position fat content index, each portion
It bit test 3 times, is averaged.Test data is shown in Table 3.Volunteer is paid a return visit after test, all indicates the closure of face
Property acne, inflamed papules, useless fellow have obtained good healing, and have not recurred.
3 volunteer's oil control and acne removal test recording table of table
。
As seen from Table 3, skin essence liquid is repaired obtained by the embodiment of the present invention 5 with good oil control and acne removal effect.
The above described is only a preferred embodiment of the present invention, limitation in any form not is done to the present invention, therefore
All contents without departing from technical solution of the present invention, it is made to the above embodiment according to the technical essence of the invention any simply to repair
Change, equivalent variations and modification, all of which are still within the scope of the technical scheme of the invention.
Claims (9)
1. a kind of oil control and acne removal preparation, which is characterized in that be made by the component of following parts by weight: corn poppy spends 1-5 parts, meadow sweet
5-10 parts, radix paeoniae rubra 1-5 parts of river.
2. oil control and acne removal preparation according to claim 1, which is characterized in that be made by the component of following parts by weight: Yu Mei
People spends 2 parts, 8 parts of meadow sweet, 1 part of river radix paeoniae rubra.
3. oil control and acne removal preparation according to claim 1 or 2, which is characterized in that the preparation of the oil control and acne removal preparation
Method includes the following steps:
(1) corn poppy is spent, the complete stool crushing of the complete stool of meadow sweet, river radix paeoniae rubra, obtains plant powder；It is soaked in water；It opens micro-
Wave processing, is cooled to room temperature, and obtains leaching liquor；
(2) leaching liquor is centrifuged, takes supernatant；Ethanol solution is added, stirs evenly；It is filtered after standing, takes filtrate, Rotary Evaporators subtract
Pressure concentration, obtains medicinal extract；By medicinal extract with water redissolve to get.
4. oil control and acne removal preparation according to claim 3, which is characterized in that the additive amount of water described in step (1) is to plant
10-20 times of object powder weight, the time that is soaked in water are 1-5 hours.
5. oil control and acne removal preparation according to claim 3, which is characterized in that the power of microwave described in step (1) is
400W, the processing time of the microwave are 10-30 minutes.
6. oil control and acne removal preparation according to claim 3, which is characterized in that the volume of ethanol solution described in step (2)
Concentration is 95%, and the additive amount of the ethanol solution is 3-5 times of supernatant weight.
7. oil control and acne removal preparation according to claim 3, which is characterized in that time of repose is 6-12 hours in step (2),
The filtering uses 100-1000 mesh filter-cloth filtering, and the dosage of water is 10-20 times of medicinal extract weight when the redissolution.
8. one kind repairs skin essence liquid, which is characterized in that the component including following mass percentage:
。
9. according to claim 8 repair skin essence liquid, which is characterized in that also contain the component of following mass percentage:
Dendrobium candidum (DENDROBIUM CANDIDUM) extract 0.1-1%,
Ou Dancan (SALVIA SCLAREA) extract 0.1-1%,
Honeysuckle (LONICERA JAPONICA) flower extract 0.1-1%.
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Cited By (1)
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|---|---|---|---|---|
| CN111228183A (en) * | 2020-03-24 | 2020-06-05 | 广州睿新生物科技有限公司 | Composition for conditioning skin and preparation method thereof |
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