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CN108434064A - Have both the skin care item of skin anti-inflammatory Eradicates acnes and repair function - Google Patents

Have both the skin care item of skin anti-inflammatory Eradicates acnes and repair function Download PDF

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Publication number
CN108434064A
CN108434064A CN201810578451.1A CN201810578451A CN108434064A CN 108434064 A CN108434064 A CN 108434064A CN 201810578451 A CN201810578451 A CN 201810578451A CN 108434064 A CN108434064 A CN 108434064A
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Prior art keywords
skin
skin care
care item
inflammatory
repair function
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Inventor
黄继奇
陈保华
李聪暖
王锐辉
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GUANGZHOU HOUDY GROUP CO Ltd
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GUANGZHOU HOUDY GROUP CO Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Botany (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Cosmetics (AREA)

Abstract

The invention discloses the skin care item for having both skin anti-inflammatory Eradicates acnes and repair function, which contains function composition, and the mass fraction of the component and each component of the function composition in skin care item is：Keratin 0.3%~5%, aloe extract 0.1%~5%, Semen Armeniacae Amarum extract 0.1%~5%, chitosan 0.5%~5%.The skin care item have three kinds of facial mask liquid, skin care cream, facial treatment milk forms.Using skin care item of the present invention, it can effectively inhibit scytitis reaction and anti-acne, and Skin Cell self-renewing and reparation can be made, to enhance the compactibility and elasticity of skin, have effects that anti aging effect.

Description

Have both the skin care item of skin anti-inflammatory Eradicates acnes and repair function
Technical field
The invention belongs to skin care fields, more particularly to the skin care item with anti-inflammatory suppression acne and repair function.
Background technology
Skin has both sides barrier action：On the one hand the loss of internal water, electrolyte and other substances is prevented；Separately On the one hand the intrusion for preventing extraneous harmful substance, keeps the stabilization of human internal environment, is physiologically playing important defencive function. The environment irradiation of influence and ultraviolet light to skin that there are pollutants in air, water body to skin residing for people, thus skin holds Easily there is allergic inflammation or long acne, and with age, skin is easy to lack nutrition, and then makes skin dehydration, destroys skin The keratin of skin, causes pachylosis, follows the string.Therefore, skin care item are widely used, and the type of skin care item is more and more.
CN201710429123.0 discloses " the protein skin care item with skin repair and care action ", the skin care item By the way that the protein compositions being made of keratin, polysaccharide, sodium alginate are added in formula, cell pair can be promoted by obtaining having The absorption of protein, to further increase self-renewing and the repair ability of Skin Cell, after especially improving ultraviolet burn The repairing effect of skin.But the protein skin care item are poor to the anti-inflammatory suppression acne effect of skin, and to the repair function side of skin Face is to be improved.On the other hand, the formula of various skin care item is different in the prior art, and effect also difference is developed more Different formulations and the good skin care item of effect are still the expectation of people.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide the shields for having both skin anti-inflammatory Eradicates acnes and repair function Skin product, to meet the needs of people are to skin care.
The skin care item of the present invention for having both skin anti-inflammatory Eradicates acnes and repair function, containing function composition, the function Mass fraction of the component and each component of composition in skin care item be：Keratin 0.3%~5%, aloe extract 0.1%~ 5%, Semen Armeniacae Amarum extract 0.1%~5%, chitosan 0.5%~5%.
The skin care item of the present invention for having both skin anti-inflammatory Eradicates acnes and repair function, including facial mask liquid, skin care cream, skin care Three kinds of lotion, their component and the mass fraction difference of each component are as follows.
1, the mass fraction of the component of facial mask liquid and each component：
The nourishing additive agent is at least one in vitamin e acetate, hyaluronic acid and its salt, D-pantothenyl aleohol, allantoin Kind；The pure water is deionized water or distilled water.
The above-mentioned skin care item for having both skin anti-inflammatory Eradicates acnes and repair function, the moisturizer are glycerine, propylene glycol, fourth two At least one of alcohol, ceramide；The solubilizer be spermaceti alcohol ether -20, different spermaceti alcohol ether -20, spermaceti alcohol ether -12, At least one of Cremophor RH40；The thickener is xanthan gum, guar gum and its derivative, hydroxy ethyl fiber Element, hydroxypropyl methyl cellulose, cationic hydroxyethyl cellulose, carbomer, acrylate/C10-30 alkyl acrylates crosslinking At least one of polymer.
2, the mass fraction of the component of skin care cream and each component：
The nourishing additive agent is in vitamin e acetate, hyaluronic acid and its salt, D-pantothenyl aleohol, phytosterol, allantoin At least one；The pure water is deionized water or distilled water.
The above-mentioned skin care item for having both skin anti-inflammatory Eradicates acnes and repair function, the grease are cetanol, stearyl alcohol, behenyl At least one of alcohol, dimethyl silicone polymer, X 2-1401, shea butter, avocado oil, olive oil；It is described Moisturizer is at least one of glycerine, butanediol, propylene glycol, glycine betaine, ceramide；The emulsifier is glycerol stearate Ester, Glucate SS, at least one of PEG-20 Glucate SSs；The thickener For xanthan gum, guar gum and its derivative, carbomer, acrylate/C10-30 alkyl acrylate cross-linked polymers, bay At least one of alcohol polyethers -7/C13-C14 isoparaffins/polyacrylamide.
3, the mass fraction of the component of facial treatment milk and each component：
The nourishing additive agent is in vitamin e acetate, hyaluronic acid and its salt, D-pantothenyl aleohol, phytosterol, allantoin At least one；The pure water is deionized water or distilled water.
The above-mentioned skin care item for having both skin anti-inflammatory Eradicates acnes and repair function, the grease are cetanol, stearyl alcohol, different 16 At least one in alkane, cetin, isopropyl myristate, X 2-1401, shea butter, avocado oil Kind；The emulsifier is spermaceti alcohol ether -20, stearine, spermaceti stearic acid alcohol ether -25, methyl glucoside times semi-solid fat Acid esters, at least one of PEG-20 Glucate SSs.
The above-mentioned skin care item for having both skin anti-inflammatory Eradicates acnes and repair function, the moisturizer are glycerine, butanediol, the third two At least one of alcohol, glycine betaine, ceramide；The thickener is in xanthan gum, guar gum and its derivative, carbomer At least one.
The skin care item of the present invention for having both skin anti-inflammatory Eradicates acnes and repair function, the molecular weight of contained keratin≤ 100000 dalton.
The skin care item of the present invention for having both skin anti-inflammatory Eradicates acnes and repair function, the deacetylation rate shadow of institute's chitosan-containing The anti-inflammatory anti-acne effect of skin is rung, experiments have shown that, the deacetylation rate of chitosan cannot be less than 75%, and as chitosan goes second The anti-inflammatory anti-acne effect of the raising of acylation rate improves, and the chitosan deacetylation rate of market sale may be up to 99%, but chitosan Deacetylation rate is higher, and price is higher, considers from cost and anti-inflammatory anti-acne effect, and the deacetylation rate of chitosan is preferred 75%~80%.
Essence and preservative can also be contained in the skin care item of the present invention for having both the anti-inflammatory Eradicates acnes of skin and repair function. Essence containing mass fraction 0.05%~0.5% in the facial treatment mask liquid, the anti-corrosion of mass fraction 0.01%~0.5% Agent；The essence of mass percent 0.05%~0.7% can be contained in the skin care cream, mass percent 0.01%~0.5% Preservative；Can contain in the facial treatment milk mass percent be 0.05%~0.6% essence, mass percent 0.01%~ 0.5% preservative.The preservative is methyl hydroxybenzoate, propylben, imidazolidinyl urea, bis- (methylol) imidazolidinyls At least one of urea, iodine propilolic alcohol butyl mephenesin Carbamate, Phenoxyethanol, Chlorphenesin, benzyl alcohol.
The preparation method of facial mask liquid of the present invention：After addition pure water and thickener are uniformly dispersed in water phase pot, it is added Moisturizer, keratin, aloe extract, Semen Armeniacae Amarum extract, stir evenly, and add essence (if having this component), preservative If the solution that (having this component) and nourishing additive agent, chitosan and solubilizer are formed, discharge to clean container after being stirred until homogeneous.
The preparation method of skin care cream of the present invention, facial treatment milk：Grease, chitosan, emulsifier (oil-soluble) is former Material input oil phase pot after the raw material is completely dissolved, is warming up to 85 DEG C, and keep under stiring in normal heating to 60 DEG C The temperature；Emulsifier (water solubility), moisturizer, thickener and pure water are added in water phase pot, turn on agitator is stirred to complete It dissolves and is uniformly mixed, then heat to 85 DEG C, and keep the temperature.Emulsification pot is evacuated to -0.05MPa, then successively By the 3/4 water phase material input emulsification pot in water phase pot, by whole oil phase materials input emulsification pot in oil phase pot, by water phase pot In remaining 1/4 water phase material input emulsification pot, open stirring homogenizer, beat homogeneous 15 minutes, then mix slowly to system Deaeration.The mixed material emulsified in pot is cooled to 50 DEG C after, keratin, aloe extract, Semen Armeniacae Amarum extract, battalion is added Additive, essence (if having this component) and preservative (if having this component) are supported, when the material being added mixes with other materials After even, 40 DEG C of dischargings are cooled to clean container.
Compared with prior art, the invention has the advantages that：
1, due to containing keratin, chitosan, aloe extract, Semen Armeniacae Amarum extract composition in skin care item of the present invention Function composition, thus effectively scytitis can be inhibited to react.(see embodiment 17).
2, due to containing keratin, chitosan, aloe extract, Semen Armeniacae Amarum extract composition in skin care item of the present invention Function composition, thus " whelk " can be effectively inhibited, have the effect of anti-acne (see embodiment 18).
3, the nutritional ingredient in skin care item of the present invention is absorbed by the skin, and can make Skin Cell self-renewing and reparation, To enhance the compactibility and elasticity of skin, has effects that anti aging effect (see embodiment 19).
4, due to containing keratin, chitosan, aloe extract, Semen Armeniacae Amarum extract composition in skin care item of the present invention Function composition, thus it is inhibited to scytitis reaction caused by ultraviolet ray burn, to quickly repairing Multiple effect (see embodiment 20).
5, polarity active force can be generated with hydrone containing a large amount of polar groups are contained in skin care item of the present invention, subtracted Few skin surface hydrone evaporation, to make skin that there is preferably moistening effect.
6, through examining, skin care item of the present invention meet sanitary index, and specific data see the table below：
Sanitary index
Specific implementation mode
The skin care item of the present invention for having both the anti-inflammatory Eradicates acnes of skin and repair function are made further below by embodiment Explanation.
In following embodiments, aloe extract, Semen Armeniacae Amarum extract and chitosan are bought by market, and chitosan is gone Acetyl rate is 80%.
Embodiment 1 prepares keratin
Wool is cleaned up, is crushed, with the thioacetic acid sodium solution (sodium hydroxide that pH value is 11, concentration 0.5mol/L Adjust pH) it is pre-processed 3 hours in normal pressure, (20 DEG C~30 DEG C) of room temperature, urea is then added into solution, the addition of urea is Concentration in the solution reaches 7mol/L, in normal pressure, room temperature (20 DEG C~30 DEG C) reduction reaction 25 hours, reaction time after Man Hou instills the pH value of acetic acid adjusting reaction solution to 6~8, oxygen is then passed through into solution, anti-in room temperature (20 DEG C~30 DEG C) It answers 0.5 hour, after the reaction time expires, in natural filtration, filtrate is oozed with the dialysis bag of retention relative molecular weight 100kD Analysis is centrifugally separating to obtain the keratin solution first product of the dalton of molecular weight≤100000, keratin solution first product is saltoutd Keratin solid is obtained, through vacuum drying at room temperature, that is, obtains natural wool keratin, yield 42%.
The keratin used in following embodiment is keratin prepared by 1 the method for embodiment.
Embodiment 2~6 is the preparation of facial mask liquid.
Embodiment 2
In the present embodiment, the component (raw material) of facial mask liquid and the mass fraction of each component are as follows：
The preparation method of facial mask liquid：After addition deionized water, carbomer dispersion are uniform in water phase pot, addition propylene glycol, Butanediol, aloe extract, Semen Armeniacae Amarum extract, keratin stir evenly, then that chitosan, vitamin e acetate, D- is general Alcohol and spermaceti alcohol ether -20, different spermaceti alcohol ether -20 are mixed and made into solution and are added in water phase pot, discharge to cleaning after being stirred until homogeneous Container.
Embodiment 3
In the present embodiment, the component (raw material) and its mass fraction of facial mask liquid are as follows：
The preparation method of facial mask liquid：After addition deionized water, xanthan gum are uniformly dispersed in water phase pot, glycerine, god is added It through amide, aloe extract, keratin, Semen Armeniacae Amarum extract, stirs evenly, then by essence, Chlorphenesin, vitamin E second The solution that acid esters, allantoin, Sodium Hyaluronate, chitosan and Cremophor RH40 are mixed is added in water phase pot, stirs It mixes to uniformly rear and discharges to clean container.
Embodiment 4
In the present embodiment, the component (raw material) and its mass fraction of facial mask liquid are as follows：
The preparation method of facial mask liquid：In water phase pot be added deionized water, cationic hydroxyethyl cellulose, acrylate/ After C10-30 alkyl acrylate cross-linked polymers are uniformly dispersed, be added propylene glycol, ceramide, keratin, aloe extract, Semen Armeniacae Amarum extract stirs evenly, and chitosan, D-pantothenyl aleohol, Sodium Hyaluronate and spermaceti alcohol ether -12 are then mixed and made into solution It is added in water phase pot, discharges to clean container after being stirred until homogeneous.
Embodiment 5
In the present embodiment, the component (raw material) and its mass fraction of facial mask liquid are as follows：
The preparation method of facial mask liquid：Distilled water, guar gum and its derivative, cationic hydroxyethyl are added in water phase pot After cellulose is uniformly dispersed, propylene glycol, keratin, aloe extract, Semen Armeniacae Amarum extract is added and stirs evenly, it is then that D- is general Alcohol, allantoin, chitosan and spermaceti alcohol ether -20 are mixed and made into solution and are added in water phase pot, discharge to cleaning after being stirred until homogeneous Container.
Embodiment 6
In the present embodiment, the component (raw material) and its mass fraction of facial mask liquid are as follows：
The preparation method of facial mask liquid：Distilled water, hydroxyethyl cellulose, hydroxypropyl methyl cellulose point are added in water phase pot After dissipating uniformly, ceramide, aloe extract, keratin, Semen Armeniacae Amarum extract is added and stirs evenly, shell then will be added and gather The solution that sugar, vitamin e acetate are mixed with different spermaceti alcohol ether -20, discharges after being stirred until homogeneous to clean container.
Embodiment 7~11 is the preparation of skin care cream
Embodiment 7
In the present embodiment, the component (raw material) and its mass fraction of cream are as follows：
The preparation method of cream：By cetanol, stearyl alcohol, shea butter, Glucate SS, PEG-20 Glucate SS, chitosan put into oil phase pot, under stiring in normal heating to 60 DEG C, when being completely dissolved Afterwards, 85 DEG C are warming up to, and keeps the temperature；Addition deionized water, ceramide, carbomer in water phase pot, turn on agitator, Stirring then heats to 85 DEG C, and keep the temperature to being completely dissolved and being uniformly mixed.Will emulsification pot be evacuated to- 0.05MPa, it is then successively by the 3/4 water phase material input emulsification pot in water phase pot, whole oil phase materials in oil phase pot are defeated Enter to emulsify pot, by remaining 1/4 water phase material input emulsification pot in water phase pot, opens stirring homogenizer, beat homogeneous 15 minutes, open Open stirring, deaeration.The mixed material emulsified in pot 50 DEG C of addition keratin, aloe extract, semen armeniacae amaraes are cooled to after to carry Take object, vitamin e acetate, D-pantothenyl aleohol, allantoin, when the material that is added with other materials after mixing, be cooled to 40 DEG C discharging is to clean container.
Embodiment 8
In the present embodiment, the component (raw material) and its mass fraction of cream are as follows：
The preparation method of cream：By docosyl alcohol, avocado oil, stearine, Glucate SS, shell Glycan input oil phase pot after being completely dissolved, is warming up to 85 DEG C, and keep the temperature under stiring in normal heating to 60 DEG C； Distilled water, ceramide, propylene glycol, xanthan gum are added in water phase pot, turn on agitator stirs equal to being completely dissolved and mixing It is even, 85 DEG C are then heated to, and keep the temperature.Emulsification pot is evacuated to -0.05MPa, it then successively will be in water phase pot 3/4 water phase material input emulsification pot, by whole oil phase materials input emulsification pot in oil phase pot, by water phase pot remaining 1/4 Water phase material input emulsification pot, opens stirring homogenizer, beats homogeneous 15 minutes, open stirring, deaeration.It will be in emulsification pot after Mixed material is cooled to 50 DEG C and keratin, aloe extract, Semen Armeniacae Amarum extract, vitamin e acetate, D-pantothenyl aleohol, plant is added Object sterol, when the material that is added with other materials after mixing, be cooled to 40 DEG C of dischargings to clean container.
Embodiment 9
In the present embodiment, the component (raw material) and its mass fraction of cream are as follows：
The preparation method of cream：By dimethyl silicone polymer, X 2-1401, olive oil, glycerol stearate Ester, PEG-20 Glucate SSs, chitosan put into oil phase pot, under stiring in normal heating to 60 DEG C, when After being completely dissolved, 85 DEG C are warming up to, and keeps the temperature；Deionized water, propylene glycol, xanthan gum, Guar are added in water phase pot Bean gum and its derivative, turn on agitator stir to being completely dissolved and being uniformly mixed, then heat to 85 DEG C, and keep the temperature Degree.Emulsification pot is evacuated to -0.05MPa, then successively by the 3/4 water phase material input emulsification pot in water phase pot, by oil phase Remaining 1/4 water phase material input emulsification pot in water phase pot it is equal to be opened stirring by whole oil phase materials input emulsification pot in pot Matter device beats homogeneous 15 minutes, opens stirring, deaeration.After by emulsify pot in mixed material be cooled to 50 DEG C be added keratin, Aloe extract, Semen Armeniacae Amarum extract, D-pantothenyl aleohol, allantoin, when the material that is added with other materials after mixing, cooling It discharges to 40 DEG C to clean container.
Embodiment 10
In the present embodiment, the component (raw material) and its mass fraction of cream are as follows：
The preparation method of cream：Olive oil, shea butter, stearine, chitosan are put into oil phase pot, stirred Under in normal heating to 60 DEG C, after being completely dissolved, be warming up to 85 DEG C, and keep the temperature；Deionization is added in water phase pot Water, butanediol, propylene glycol, ceramide, acrylate/C10-30 alkyl acrylate cross-linked polymers, laureth -7/ C13-C14 isoparaffins/polyacrylamide, turn on agitator stir to being completely dissolved and being uniformly mixed, then heat to 85 DEG C, and keep the temperature.Emulsification pot is evacuated to -0.05MPa, then successively inputs 3/4 water phase material in water phase pot Pot is emulsified, by whole oil phase materials input emulsification pot in oil phase pot, by remaining 1/4 water phase material input emulsification in water phase pot Pot opens stirring homogenizer, beats homogeneous 15 minutes, opens stirring, deaeration.The mixed material emulsified in pot is cooled to 50 after DEG C keratin, aloe extract, Semen Armeniacae Amarum extract, Sodium Hyaluronate, D-pantothenyl aleohol, essence, Chlorphenesin is added, when being added Material and other materials after mixing, be cooled to 40 DEG C of dischargings to clean container.
Embodiment 11
In the present embodiment, the component (raw material) and its mass fraction of cream are as follows：
The preparation method of cream：Olive oil, Glucate SS, chitosan are put into oil phase pot, stirred It mixes down in normal heating to 60 DEG C, after being completely dissolved, is warming up to 85 DEG C, and keep the temperature；In water phase pot be added go from Sub- water, glycerine, propylene glycol, glycine betaine, xanthan gum, guar gum and its derivative, carbomer, turn on agitator are stirred to complete Fully dissolved is simultaneously uniformly mixed, and then heats to 85 DEG C, and keeps the temperature.Will emulsification pot be evacuated to -0.05MPa, then according to 3/4 water phase material input emulsification pot in the secondary pot by water phase, by whole oil phase materials input emulsification pot in oil phase pot, by water phase Remaining 1/4 water phase material input emulsification pot, opens stirring homogenizer, beats homogeneous 15 minutes, open stirring, deaeration in pot.After The mixed material emulsified in pot is cooled to 50 DEG C afterwards, keratin, aloe extract, Semen Armeniacae Amarum extract, hyaluronic acid is added Sodium, when the material that is added with other materials after mixing, be cooled to 40 DEG C of dischargings to clean container.
Embodiment 12~16 is the preparation of facial treatment milk
Embodiment 12
In the present embodiment, the component (raw material) and its mass fraction of lotion are as follows：
The preparation method of lotion：By cetanol, stearyl alcohol, shea butter, Glucate SS, PEG-20 Glucate SS, chitosan put into oil phase pot, under stiring in normal heating to 60 DEG C, when the raw material is complete After fully dissolved, 85 DEG C are warming up to, and keeps the temperature；Distilled water, ceramide, carbomer are added in water phase pot, unlatching is stirred Device is mixed, stirs to being completely dissolved and being uniformly mixed, then heats to 85 DEG C, and keep the temperature.Will emulsification pot be evacuated to- 0.05MPa, it is then successively by the 3/4 water phase material input emulsification pot in water phase pot, whole oil phase materials in oil phase pot are defeated Enter to emulsify pot, by remaining 1/4 water phase material input emulsification pot in water phase pot, opens stirring homogenizer, beat homogeneous 15 minutes, open Open stirring, deaeration.The mixed material emulsified in pot 50 DEG C of addition keratin, aloe extract, semen armeniacae amaraes are cooled to after to carry Take object, vitamin e acetate, D-pantothenyl aleohol, allantoin, when the material that is added with other materials after mixing, be cooled to 40 DEG C discharging is to clean container.
Embodiment 13
In the present embodiment, the component (raw material) and its mass fraction of lotion are as follows：
The preparation method of lotion：By isohexadecane, stearyl alcohol, avocado oil, spermaceti alcohol ether -20, spermaceti stearic acid alcohol ether - 25, chitosan input oil phase pot after the raw material is completely dissolved, is warming up to 85 DEG C under stiring in normal heating to 60 DEG C, And keep the temperature；Deionized water, ceramide, propylene glycol, xanthan gum are added in water phase pot, turn on agitator, stirring is extremely It is completely dissolved and is uniformly mixed, then heat to 85 DEG C, and keep the temperature.Emulsification pot is evacuated to -0.05MPa, then Successively by the 3/4 water phase material input emulsification pot in water phase pot, by whole oil phase materials input emulsification pot in oil phase pot, by water Remaining 1/4 water phase material input emulsification pot, opens stirring homogenizer, beats homogeneous 15 minutes, open stirring, deaeration in phase pot. The mixed material emulsified in pot is cooled to 50 DEG C after, keratin, aloe extract, Semen Armeniacae Amarum extract, vitamin E is added Acetic acid esters, D-pantothenyl aleohol, phytosterol, essence, Bis(hydroxymethyl)imidazolidinyl urea, when the material being added is mixed with other materials After uniformly, 40 DEG C of dischargings are cooled to clean container.
Embodiment 14
In the present embodiment, the component (raw material) and its mass fraction of lotion are as follows：
The preparation method of lotion：By chitosan, cetin, isohexadecane, isopropyl myristate, glyceryl stearate Acid esters, spermaceti stearic acid alcohol ether -25 put into oil phase pot, under stiring in normal heating to 60 DEG C, when the raw material is completely dissolved Afterwards, 85 DEG C are warming up to, and keeps the temperature；Deionized water, glycerine, butanediol, propylene glycol, guar gum are added in water phase pot And its derivative, turn on agitator stir to being completely dissolved and being uniformly mixed, then heat to 85 DEG C, and keep the temperature.It will Emulsification pot is evacuated to -0.05MPa, will be in oil phase pot then successively by the 3/4 water phase material input emulsification pot in water phase pot Remaining 1/4 water phase material input emulsification pot in water phase pot is opened stirring homogenizer by whole oil phase material input emulsification pots, It beats homogeneous 15 minutes, opens stirring, deaeration.The mixed material emulsified in pot is cooled to 50 DEG C after, keratin, aloe is added Extract, Semen Armeniacae Amarum extract, allantoin, D-pantothenyl aleohol, phytosterol, when the material being added is uniformly mixed with other materials Afterwards, 40 DEG C of dischargings are cooled to clean container.
Embodiment 15
In the present embodiment, the component (raw material) and its mass fraction of lotion are as follows：
The preparation method of lotion：By shea butter, avocado oil, stearine, Glucate SS, Chitosan puts into oil phase pot, under stiring in normal heating to 60 DEG C, after the raw material is completely dissolved, is warming up to 85 DEG C, and Keep the temperature；Distilled water, glycerine, glycine betaine, propylene glycol, guar gum and its derivative, xanthan gum are added in water phase pot, Turn on agitator stirs to being completely dissolved and being uniformly mixed, then heats to 85 DEG C, and keep the temperature.Emulsification pot is taken out very Empty extremely -0.05MPa, then successively by the 3/4 water phase material input emulsification pot in water phase pot, by whole oil phase things in oil phase pot Remaining 1/4 water phase material input emulsification pot in water phase pot is opened stirring homogenizer, makes 15 scores of homogeneous by material input emulsification pot Clock opens stirring, deaeration.The mixed material emulsified in pot is cooled to 50 DEG C after, keratin, aloe extract, bitter apricot is added Benevolence extract, Sodium Hyaluronate, vitamin e acetate, essence, methyl hydroxybenzoate, when the material being added is mixed with other materials After closing uniformly, 40 DEG C of dischargings are cooled to clean container.
Embodiment 16
In the present embodiment, the component (raw material) and its mass fraction of facial treatment milk are as follows：
The preparation method of lotion：X 2-1401, spermaceti alcohol ether -20, chitosan are put into oil phase pot, stirred It mixes down in normal heating to 60 DEG C, after the raw material is completely dissolved, is warming up to 85 DEG C, and keep the temperature；In water phase pot Deionized water, glycerine, ceramide, propylene glycol, guar gum and its derivative, carbomer, xanthan gum is added, opens stirring Device stirs to being completely dissolved and being uniformly mixed, then heats to 85 DEG C, and keep the temperature.Will emulsification pot be evacuated to- 0.05MPa, it is then successively by the 3/4 water phase material input emulsification pot in water phase pot, whole oil phase materials in oil phase pot are defeated Enter to emulsify pot, by remaining 1/4 water phase material input emulsification pot in water phase pot, opens stirring homogenizer, beat homogeneous 15 minutes, open Open stirring, deaeration.The mixed material emulsified in pot 50 DEG C of addition keratin, aloe extract, semen armeniacae amaraes are cooled to after to carry Take object, Sodium Hyaluronate, when the material that is added with other materials after mixing, be cooled to 40 DEG C of dischargings to clean container.
The anti-inflammatory effect of 17 keratin composition of embodiment is tested
A, B, C, D, E, F group are set, are respectively：A groups, the mass concentration prepared with keratin prepared by embodiment 1 3.0% keratin aqueous solution；B groups, 3.0% chitosan aqueous solution of mass concentration；C groups, the aloe extraction of mass concentration 3.0% Object aqueous solution；D groups, the Semen Armeniacae Amarum extract aqueous solution of mass concentration 3.0%；E groups, function composition solution, in the solution, The mass fraction 2.5% of keratin, the mass fraction 2.0% of chitosan, the mass fraction 1.5% of aloe extract, semen armeniacae amarae The mass fraction 1.5% of extract, F groups：Distilled water.
A, B, C, D, E, F group are added in the culture solution containing positive agent (institute's band in kit) respectively and form six tissue cultures Normal human dermal's cell is respectively placed in six groups of culture solutions by nutrient solution, using high glucose medium saturated humidity, 37 DEG C of constant temperature, It is cultivated 24 hours under 5v.% carbon dioxide conditions.
It after culture, is measured with ELISA experiments (enzyme-linked immunosorbent), uses IL-6 (interleukin-6) reagent respectively Box measures the expression of IL-6, the expression of TNF-α (tumor necrosis factor) kit measurement TNF-α.Test result is shown in Table 1：
Table 1
Test result shows that E groups, i.e. function composition can obviously inhibit inflammatory factor IL-6 and TNF-α in dermal cell In expression, scytitis is significantly inhibited.
18 skin care item of embodiment are to crowd's Eradicates acne measure of merit
1, test sample
(1) facial mask liquid prepared by above-described embodiment 4
(2) creams prepared by above-described embodiment 9
(3) lotion prepared by above-described embodiment 14
(4) reference sample：By the constituent component of above-described embodiment 4, the facial mask liquid of remove function composition, reference sample The mass percent of component and each component is as follows：
Moisturizer 5.0%：Propylene glycol 3.5%, Cer EOS .5%
Thickener 1.0%：Cationic hydroxyethyl cellulose 0.6%, acrylate/C10-30 alkyl acrylates crosslinking are poly- Close object 0.4%
Solubilizer 0.8%：Spermaceti alcohol ether -12
Nourishing additive agent 2.6%：D-pantothenyl aleohol 1.3%, Sodium Hyaluronate 1.3%
Deionized water 90.6%
2, test object
Skin has between 21 18 years old~25 years old ages " whelk " women, by 21, test object is randomly divided into three Group is respectively designated as A groups, B groups, C groups, every group of 7 people.
3, test method
(1) above-mentioned facial mask liquid and reference sample are used respectively in the left and right face of A group test objects, in B group test objects Left and right face respectively use above-mentioned creams and reference sample, C group test objects left and right face respectively use above-mentioned breast Liquid and reference sample；
(2) A, B, C group tester continuous use 14 days, daily sooner or later respectively using once, the amount of each facial mask liquid of A groups is 15 Gram, the dosage of each creams of B groups is 3 grams, the dosage of each lotion of C groups is 3 grams.A, the dosage of each reference sample of B, C group point It Wei not be 15 grams, 3 grams, 3 grams." whelk " the disappearance situation of range estimation.
4, test result
A groups test object is averagely censured mistake 72% using face's whelk of facial mask liquid, and B group test objects use the face of creams Portion's whelk is averagely censured mistake 61%, and C groups test object is averagely censured mistake 58% using face's whelk of lotion.A, B, C group are tested Object has no apparent disappearance using face's whelk of reference sample.
19 skin care item of embodiment test skin elasticity enhancing effect
1, test sample
(1) facial mask liquid prepared by above-described embodiment 4
(2) creams prepared by above-described embodiment 9
(3) lotion prepared by above-described embodiment 14
(4) reference sample：By the constituent component of above-described embodiment 4, the facial mask liquid of remove function composition, reference sample The mass percent of component and each component is as follows：
Moisturizer 5.0%：Propylene glycol 3.5%, Cer EOS .5%
Thickener 1.0%：Cationic hydroxyethyl cellulose 0.6%, acrylate/C10-30 alkyl acrylates crosslinking are poly- Close object 0.4%
Solubilizer 0.8%：Spermaceti alcohol ether -12
Nourishing additive agent 2.6%：D-pantothenyl aleohol 1.3%, Sodium Hyaluronate 1.3%
Deionized water 90.6%
2, test object
40 test objects are randomly divided into four groups by health without dermopathic women between 40 35 years old~50 years old ages, It is respectively designated as A groups, B groups, C groups and D groups, every group of 10 people.
3, test method
(1) determine test zone on the left and right forearm of four groups of test objects, the area of test zone be 5cm × 5cm；
(2) the skin water of 200 four groups of test object test zones of type keratoderma water content measuring instrument pair of SKICON is used With being tested, the skin elasticity that inspection four groups of test object test zones of instrument pair are surveyed with SEM575 type skin elasticities is surveyed for cooperation Examination, this test result are referred to as initial value.
(3) A groups test object uses above-described embodiment using the facial mask liquid prepared by above-described embodiment 4, B group test objects Creams prepared by 9, C group test objects are using the facial treatment milk prepared by above-described embodiment 14, described in D group test object uses Reference sample is used continuously ten days, and daily morning Dinner, each dosage was 1.0 grams respectively using once.
(4) test sample is used continuously after ten days in A, B, C, D group test object, with 200 type keratoderma water of SKICON Content measuring instrument tests the skin hydration effect of each group test object test zone, is surveyed and is examined with SEM575 type skin elasticities Instrument tests the skin elasticity of each group test object test zone, this test result is referred to as test value.
4, test result
(1) test result of A groups
Comparing with intial value, subjects skin's average capacitance increases by 41.7% to test value, and subjects skin's average elasticity increases Add 17.8%, subjects skin's compactibility that is averaged increases by 16.7%.
(2) test result of B groups
Comparing with intial value, subjects skin's average capacitance increases by 34.2% to test value, and subjects skin's average elasticity increases Add 15.8%, subjects skin's compactibility that is averaged increases by 13.3%.
(3) test result of C groups
Comparing with intial value, subjects skin's average capacitance increases by 35.1% to test value, and subjects skin's average elasticity increases Add 16.3%, subjects skin's compactibility that is averaged increases by 12.6%.
(4) test result of D groups
Comparing with intial value, subjects skin's average capacitance increases by 3.7% to test value, and subjects skin's average elasticity increases 2.1%, subjects skin be averaged compactibility increase by 2.8%.
20 skin care item of embodiment test skin sunburn repairing effect
1, test sample
(1) facial mask liquid prepared by above-described embodiment 4
(2) creams prepared by above-described embodiment 9
(3) facial treatment milk prepared by above-described embodiment 14
(4) reference sample：By the constituent component of above-described embodiment 4, the facial mask liquid of remove function composition, reference sample The mass percent of component and each component is as follows：
Moisturizer 5.0%：Propylene glycol 3.5%, Cer EOS .5%
Thickener 1.0%：Cationic hydroxyethyl cellulose 0.6%, acrylate/C10-30 alkyl acrylates crosslinking are poly- Close object 0.4%
Solubilizer 0.8%：Spermaceti alcohol ether -12
Nourishing additive agent 2.6%：D-pantothenyl aleohol 1.3%, Sodium Hyaluronate 1.3%
Deionized water 90.6%
2, test object
40 health between 35 years old~50 years old are randomly divided into four groups without dermopathic women, by 40 test objects, respectively It is named as A groups, B groups, C groups and D groups, every group of 10 people.
3, test method
(1) determine test zone on the left and right forearm of four groups of test objects, the area of test zone be 5cm × 5cm；
(2) in the corresponding test sample of its left arm test zone painting, (A group test objects use above-mentioned every group of test object respectively Facial mask liquid prepared by embodiment 4, B group test objects use the skin cream prepared by above-described embodiment 9, C group test objects Using the facial treatment milk prepared by above-described embodiment 14, D group test objects use the reference sample), right arm does not apply then, naked Dew, the morning 11 is respectively placed in by the test section of both arms：00~13：Exposure is primary under 00 daylight, and the time is 2 hours, is observed respectively Left and right arm sunburn situation.
(3) after exposure, to A group test objects using the facial mask liquid prepared by above-described embodiment 4, B group test objects make With the creams prepared by above-described embodiment 9, C group test objects use the facial treatment milk prepared by above-described embodiment 14, the test of D groups Object carries out skin repair experiment using the reference sample, is used continuously ten days, it is early daily, in, Dinner respectively using primary, every time Dosage is 1.0 grams.
4, test result
(1) exposure 2 hours, left and right arm sunburn situation are：A, the test zone of B, C, D each group right arm and left arm occurs It tans severely red point, the red point of sunburn that A group left arms occur is that the red point of sunburn of 21%, the B group left arms appearance of A group right arms is B group right arms The red point of sunburn that occurs of 28%, C group left arms be the red points of tanning severely of 29%, D group left arms appearance of C group right arms be D group right arms 72%.
(2) after tanning severely, after corresponding test sample is used continuously in each group right arm test zone, the red point of right arm disappears after A groups 3 days It loses, the red point of right arm disappears after B groups 5 days, and the red point of right arm disappears after C groups 5 days, and D groups are after continuous use reference sample 10 days, right arm Still there is 20% red point.

Claims (10)

1. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function, it is characterised in that the skin care item contain function composition, institute Stating the mass fraction of the component and each component of function composition in skin care item is：Keratin 0.3%~5%, aloe extract 0.1%~5%, Semen Armeniacae Amarum extract 0.1%~5%, chitosan 0.5%~5%.
2. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 1, it is characterised in that the angle egg The dalton of white molecular weight≤100000.
3. the skin care item according to claim 1 or claim 2 for having both skin anti-inflammatory Eradicates acnes and repair function, it is characterised in that the shell Deacetylation rate >=75% of glycan.
4. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 3, it is characterised in that the skin care item For facial mask liquid, also contain the component of following mass fraction：
The nourishing additive agent is at least one of vitamin e acetate, hyaluronic acid and its salt, D-pantothenyl aleohol, allantoin；Institute It is deionized water or distilled water to state pure water.
5. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 4, it is characterised in that the moisturizing Agent is at least one of glycerine, propylene glycol, butanediol, ceramide；The solubilizer is spermaceti alcohol ether -20, different cetanol At least one of ether -20, spermaceti alcohol ether -12, Cremophor RH40；The thickener be xanthan gum, guar gum and Its derivative, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, cationic hydroxyethyl cellulose, carbomer, acrylate/ At least one of C10-30 alkyl acrylate cross-linked polymers.
6. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 3, it is characterised in that the skin care item For skin care cream, also contain the component of following mass fraction：
The nourishing additive agent be vitamin e acetate, hyaluronic acid and its salt, D-pantothenyl aleohol, phytosterol, in allantoin extremely Few one kind；The pure water is deionized water or distilled water.
7. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 6, it is characterised in that the grease For cetanol, stearyl alcohol, docosyl alcohol, dimethyl silicone polymer, X 2-1401, shea butter, avocado oil, olive At least one of oil；The moisturizer is at least one of glycerine, butanediol, propylene glycol, glycine betaine, ceramide；Institute It is in stearine, Glucate SS, PEG-20 Glucate SSs to state emulsifier At least one；The thickener is xanthan gum, guar gum and its derivative, carbomer, acrylate/C10-30 alkyl third At least one of olefin(e) acid ester cross-linked polymer, laureth -7/C13-C14 isoparaffins/polyacrylamide.
8. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 3, it is characterised in that the skin care item For facial treatment milk, also contain the component of following mass fraction：
The nourishing additive agent be vitamin e acetate, hyaluronic acid and its salt, D-pantothenyl aleohol, phytosterol, in allantoin extremely Few one kind；The pure water is deionized water or distilled water.
9. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 8, it is characterised in that the grease For cetanol, stearyl alcohol, isohexadecane, cetin, isopropyl myristate, X 2-1401, breast wood At least one of fruit oil, avocado oil；The emulsifier is spermaceti alcohol ether -20, stearine, spermaceti stearic acid alcohol ether - 25, Glucate SS, at least one of PEG-20 Glucate SSs.
10. having both the skin care item of skin anti-inflammatory Eradicates acnes and repair function according to claim 8 or claim 9, it is characterised in that described Moisturizer is at least one of glycerine, butanediol, propylene glycol, glycine betaine, ceramide；The thickener is xanthan gum, melon That at least one of bean gum and its derivative, carbomer.
CN201810578451.1A 2018-06-05 2018-06-05 Have both the skin care item of skin anti-inflammatory Eradicates acnes and repair function Pending CN108434064A (en)

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109364006A (en) * 2018-12-03 2019-02-22 广州润虹医药科技股份有限公司 A kind of acne-removing composition, Essence and preparation method thereof
WO2021083200A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-6, preparation method, and pharmaceutical composition and use thereof
WO2021083205A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-15, preparation method, and pharmaceutical composition and use thereof
WO2021083204A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-14, preparation method, pharmaceutical composition and use thereof
WO2021083201A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-10, preparation method therefor, and pharmaceutical composition thereof, and use thereof
CN113440466A (en) * 2021-05-26 2021-09-28 广州市万千粉丝化妆品有限公司 Skin care product containing II-type proteoglycan for promoting skin repair and improving elasticity
CN113749980A (en) * 2021-10-20 2021-12-07 康膝生物医疗(深圳)有限公司 Freeze-dried full-absorption membrane and preparation and use methods thereof
CN114366705A (en) * 2022-01-25 2022-04-19 黄远诚 Anti-wrinkle mask and preparation method and preparation device thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008273874A (en) * 2007-04-27 2008-11-13 Fuji Chem Ind Co Ltd External preparation for scalp
CN103040729A (en) * 2013-02-03 2013-04-17 福州乾正药业有限公司 Chitosan gel for removing acne scars as well as preparation method and medical application thereof
CN104083312A (en) * 2014-06-26 2014-10-08 刘书元 Acne-removing formula
CN105456176A (en) * 2015-12-29 2016-04-06 广州市科能化妆品科研有限公司 Emulsion cream and preparing method thereof
CN107260571A (en) * 2017-06-08 2017-10-20 刘佩华 Protein skin care item with skin repair and care action

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008273874A (en) * 2007-04-27 2008-11-13 Fuji Chem Ind Co Ltd External preparation for scalp
CN103040729A (en) * 2013-02-03 2013-04-17 福州乾正药业有限公司 Chitosan gel for removing acne scars as well as preparation method and medical application thereof
CN104083312A (en) * 2014-06-26 2014-10-08 刘书元 Acne-removing formula
CN105456176A (en) * 2015-12-29 2016-04-06 广州市科能化妆品科研有限公司 Emulsion cream and preparing method thereof
CN107260571A (en) * 2017-06-08 2017-10-20 刘佩华 Protein skin care item with skin repair and care action

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109364006A (en) * 2018-12-03 2019-02-22 广州润虹医药科技股份有限公司 A kind of acne-removing composition, Essence and preparation method thereof
WO2021083200A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-6, preparation method, and pharmaceutical composition and use thereof
WO2021083205A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-15, preparation method, and pharmaceutical composition and use thereof
WO2021083204A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-14, preparation method, pharmaceutical composition and use thereof
WO2021083201A1 (en) * 2019-10-28 2021-05-06 中国医学科学院药物研究所 Keratin bd-10, preparation method therefor, and pharmaceutical composition thereof, and use thereof
CN113440466A (en) * 2021-05-26 2021-09-28 广州市万千粉丝化妆品有限公司 Skin care product containing II-type proteoglycan for promoting skin repair and improving elasticity
CN113749980A (en) * 2021-10-20 2021-12-07 康膝生物医疗(深圳)有限公司 Freeze-dried full-absorption membrane and preparation and use methods thereof
CN114366705A (en) * 2022-01-25 2022-04-19 黄远诚 Anti-wrinkle mask and preparation method and preparation device thereof

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Application publication date: 20180824