CN110161268B - A device for collecting liquid samples - Google Patents

Abstract

The invention provides a device for collecting and detecting a liquid sample, which comprises a first cavity and a second cavity, wherein the first cavity is used for collecting the liquid sample and carrying out initial detection, and the second cavity is used for collecting the liquid sample for secondary confirmation detection. The first and second chambers of the device are detachably coupled. When the secondary confirmation detection is needed, the second cavity can be separated from the first cavity, and then the second cavity is sent to a confirmation detection mechanism for confirmation detection. The pollution to the sample possibly caused when the detection reagent strip of the traditional device is contacted with the liquid sample can be avoided; the space required for storing the liquid sample is effectively reduced, and the risk of leakage of the liquid sample in the transportation process is greatly reduced.

Description

A device for collecting liquid samples

This application claims priority to the prior Chinese application, application number 201810150485.0, filing date 2018-02-13.

Technical Field

The present invention relates to a device for collecting liquid samples, in particular to a device for collecting and detecting substances to be analyzed in liquid samples in the field of rapid diagnosis, such as a urine collection and detection device.

Background Art

At present, detection devices for detecting whether a sample contains an analyte are widely used in hospitals or homes. These detection devices for rapid diagnosis include one or more test strips, such as early pregnancy tests, drug abuse tests, etc. This rapid diagnosis detection device is very convenient and can obtain test results on the test strip in one minute, or at most ten minutes.

Drug testing is widely used and is often used in drug control departments, public security bureaus, drug rehabilitation centers, physical examination centers, national military conscription physical examination offices, etc. Drug testing is of various types and is performed frequently. There is a huge market demand for drug testing urine cups that can automatically separate the remaining samples from the tested samples. After the drug testing urine cups currently on the market are completed, the samples in the urine cups will be contaminated by the testing reagents and cannot be used for the second confirmation test, such as described in US Patent 7300633.

Although, in traditional technology, the sample to be tested can be isolated from the sample to be collected, it is costly and not easy to operate. For example, the piston urine cup described in U.S. Patent No. 7,300,633 allows the liquid sample in the collection chamber, such as urine, to be transferred from the collection chamber to the detection chamber when the piston is pushed forward. The detection chamber contains a test element for the substance to be analyzed in the detection sample, and the liquid sample in the collection chamber is separated by the piston, so that the samples in the two places will not be mixed, and can be used for subsequent confirmation testing. Although this can isolate the sample to be tested and the sample to be collected, this piston urine cup is costly and not easy to operate. After all, it takes a lot of force to push the piston. This is because the piston needs to achieve the transfer of the sample, and it must have a liquid sealing effect with the wall of the piston. To achieve the sealing effect, the piston and the piston chamber must be tightly combined. In addition, when performing a secondary test, the entire device must be transferred to the inspection agency for testing.

For another example, U.S. Patent 8,992,855 describes a device for collecting liquid samples, which includes a piston structure that is integrated with a lid and moves with the lid. Although the test sample can be separated from the collected sample, when the test sample enters the test chamber, it needs to overcome a large pressure to enter, and the size of the lid and the cup mouth needs to be precisely designed so that the piston integrated with the lid can be accurately inserted into the separation chamber.

In addition, after the preliminary tests of these traditional collection and detection devices are completed, if subsequent confirmation tests are required, the entire collection and detection device needs to be transported to a confirmation and detection agency for further confirmation tests, which brings many problems, at least the following problems: First, most of the current liquid collection and detection devices are only equipped with a preliminary detection chamber. If subsequent confirmation tests are required, the entire device containing urine and test reagent strips can only be sent to a confirmation and detection agency for testing. In this way, the sample in the urine cup may be contaminated by the test reagent. Second, when the entire device is sent to the confirmation and detection agency, due to the large mouth of the cup, there is a risk of liquid leakage during transportation, which requires more costs to make the device have a better sealing effect, thereby minimizing the risk of leakage; third, the confirmation and detection agency needs a huge low-temperature warehouse to store the entire detection device to prevent the liquid sample from deteriorating, in order to prepare for possible further confirmation tests.

This results in a significant increase in the cost of confirmation testing agencies (which can be called secondary testing agencies).

In view of the above-mentioned technical problems, it is necessary to improve them and provide other ways to solve the shortcomings of existing traditional technologies.

Summary of the invention

In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a detection device that can separate the initial detection sample and the confirmation detection sample (secondary detection). After collecting the liquid sample, before or after the detection, the device can allow the initial detection sample and the confirmation detection sample to enter two cavities, such as the first cavity and the second cavity, and then after or before the completion of the initial detection, the second cavity can be separated from the initial collection cavity (first cavity), thereby realizing the detachable separation of the second cavity and the cavity for the initial collection sample. The second cavity separated from the initial collection cavity can be used for the subsequent second detection or the subsequent confirmation detection. Thereby, the collection of the initial detection sample and the subsequent possible confirmation detection sample (second detection) are effectively separated, and finally the collection is witnessed at least two detections.

It can also be considered that when the collection device includes two chambers, the two chambers receive the same liquid sample, such as urine, simultaneously or in sequence, one of the chambers, such as the first chamber, is used to collect part of the liquid sample, and the other chamber, such as the second chamber, is used to collect another part of the liquid sample. After or while collecting, the liquid in the first chamber can be used to contact the test element to complete the first test, and the second chamber can be separated from the first chamber for a second test.

In a first aspect of the present invention, there is provided a device for collecting liquid samples, the device comprising: a first cavity for collecting liquid samples; and a second cavity for collecting liquid samples for confirmation and detection; wherein the first cavity and the second cavity are detachably coupled, combined or connected.

In some preferred embodiments, before the second cavity is separated from the first cavity, the first cavity and the second cavity are in a state of liquid communication; or, when the first cavity and the second cavity are combined together, the first cavity and the second cavity are in a state of liquid flow. In this way, no matter the first cavity or the second cavity is used to collect or receive the liquid sample, the liquid can flow in the two cavities, and such flow is active flow or passive flow.

In some preferred embodiments, active flow means that the liquid can flow naturally from the first cavity to the second cavity or from the second cavity to the first cavity without external force. In some preferred embodiments, passive flow means that the liquid flows from the first cavity to the second cavity or from the second cavity to the first cavity by external force. The external force here can refer to negative pressure, pressure, and compressing the liquid, thereby causing the liquid to flow.

In some preferred embodiments, after the second cavity is separated from the first cavity or before it is separated, the first cavity and the second cavity are not in liquid communication, so that the liquid does not flow between the two cavities. In some preferred embodiments, before the second cavity is separated from the first cavity or before it is separated, the first cavity and the second cavity are not in liquid communication. Or, in some preferred embodiments, while the second cavity is separated from the first cavity, the first cavity and the second cavity are not in liquid communication. In some preferred embodiments, after the second cavity is separated from the first cavity, the second cavity stores the liquid sample from the first cavity. In some preferred embodiments, when or after the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity. In some preferred embodiments, while the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity.

In some other embodiments, the first cavity and the second cavity can be detachably combined together and can be combined together through the combination position and separated through the combination position. Here, the combination means that the two cavities are separated before use, assembled together when used, and separated after use. Alternatively, the first cavity and the second cavity can be directly combined together, or indirectly combined together through a certain structure. The combination position can be the place where the first cavity and the second cavity are in physical contact. Therefore, in another aspect of the present invention, the first cavity and the second cavity are assembled together at the beginning, and after collecting the liquid sample, the second cavity is separated from the first cavity. The first cavity can be used for the first detection, and the second cavity is used for secondary detection or confirmation detection. In an optional manner, the first cavity and the second cavity are separated and not assembled together at the beginning. After collecting the liquid sample, the second cavity is combined with the first cavity, so that part of the liquid communicates or flows between the first cavity and the second cavity, and when a secondary detection is required, the two cavities are separated. The first cavity can be used for the first detection, and the second cavity is used for secondary detection or confirmation detection.

In a second aspect of the present invention, there is provided a device for collecting liquid samples, the device comprising: a first cavity for collecting liquid samples; and a second cavity for collecting liquid samples for confirmation and detection; wherein the first cavity and the second cavity are indirectly or directly detachably combined, combined or connected together through a combination position.

In some preferred embodiments, the second cavity and the first cavity are in liquid communication through a connecting channel. In some preferred embodiments, before the second cavity is separated from the first cavity, the first cavity and the second cavity are in liquid communication through the connecting channel. In some preferred embodiments, after the second cavity is separated from the first cavity or while being separated, the first cavity and the second cavity are not in liquid communication, and the channel is sealed. In some preferred embodiments, after the second cavity is separated from the first cavity, the second cavity stores a liquid sample from the first cavity. In some preferred embodiments, when or after the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity through the connecting channel. In some preferred embodiments, while the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity through the connecting channel.

In one embodiment of all the aforementioned methods, the first cavity includes an opening for collecting a liquid sample, and the liquid sample enters the first cavity through the opening. In some preferred embodiments, the connecting channel liquid connects the first cavity and the second cavity, and the liquid sample can exchange liquid between the first cavity and the second cavity through the connecting channel. In some preferred embodiments, the liquid sample can flow from the first cavity to the second cavity through the connecting channel. In some preferred embodiments, the connecting channel has a first opening and a second opening, wherein the first opening is in liquid communication with the first cavity, and the second opening is in liquid communication with the second cavity. In some preferred embodiments, the connecting channel is located on or in the first cavity. The second cavity is detachably connected, combined or combined with the first cavity through the connecting channel. Therefore, the connecting channel can allow the first cavity and the second cavity to be in an indirect detachable combination, combination or connection together.

In some preferred embodiments, the connecting channel includes a structure connecting the first cavity and the second cavity and a structure separating the first cavity and the second cavity, wherein the structure connecting the first and second cavities is the space or pipe constituting the channel. In some other preferred embodiments, alternatively, the connecting channel has two states of sealing or non-sealing, and when in the non-sealed state, the liquid can flow from the first cavity to the second cavity. Preferably, when the connecting channel is in a sealed state, the liquid in the first cavity cannot flow from the connecting channel to the second cavity. Therefore, the sealing or non-sealing of the connecting channel defines the state of liquid exchange between the first cavity and the second cavity. If the connecting channel is not sealed, liquid can be exchanged between the two cavities, and when the connecting channel is sealed, there is no liquid exchange between the two cavities.

In a third aspect of the present invention, the present invention provides a sealing element, which can seal the connecting channel and make the connecting channel in a sealed state. In a preferred manner, the connecting channel is connected to a first cavity and a second cavity, so that the second cavity and the first cavity are in a state where liquid does not flow through the sealing element. In some preferred embodiments, the device also includes a sealing element that seals the connecting channel. In some preferred embodiments, the sealing element excludes part of the liquid sample in the second cavity when sealing the channel or at the same time or after sealing. Preferably, the excluded liquid sample is discharged into the first cavity. Alternatively, when the sealing element seals the connecting channel, part of the liquid sample in the connecting channel (if any) is excluded to a place outside the connecting channel, such as the first cavity or other places. In some preferred embodiments, the sealing element may also include an elastic sealing ring, which allows the sealing element to contact the inner wall of the connecting channel, so that the sealing element is more sealed. In other preferred embodiments, the sealing element is more flexible than the connecting channel, so that by relying on the contact between the two, any one of them is deformed or squeezed, so that the sealing element and the inner wall of the connecting channel are in close contact, thereby achieving a sealing effect. For example, the sealing element is elastic and the connecting channel is rigid, so that when an external force forces the sealing element to enter the connecting channel, the elastic element is squeezed and deformed, thereby sealing the connecting channel.

In other embodiments, the sealing element and the connection are sealed by means of threads. For example, the sealing element has an external thread, the connecting channel has an internal thread, and the sealing element seals the connecting channel by relative rotation. In other preferred embodiments, the sealing element is a structure similar to a cover body, having an internal thread, and the outer edge of the first opening of the connecting channel has an external thread, so that the sealing element and the connecting channel can play a sealing role.

In a fourth aspect of the present invention, the device of the present invention may further include a drainage element, and before the sealing element seals the first opening of the connecting channel, part of the drainage element enters the second cavity. In some preferred embodiments, after the sealing element seals the opening of the connecting channel, part of the drainage element enters the second cavity. Alternatively, before the sealing element seals the first opening of the connecting channel, part of the drainage element enters the second cavity through the connecting channel.

Therefore, in a fourth aspect of the present invention, the device of the present invention provides a drainage element, which is used to discharge part of the liquid in the second cavity to the outside of the second cavity. Preferably, before the sealing element seals the first opening of the connecting channel, part of the drainage element enters the second cavity. In some preferred modes, after the sealing element seals the opening of the connecting channel, part of the drainage element enters the second cavity. Optionally, the drainage element enters the second cavity through the connecting channel, thereby discharging part of the liquid to the outside of the second cavity. In some preferred modes, the drainage element and the sealing element are connected as an integral structure. In some modes, the drainage element enters the liquid connecting channel before the sealing element. Preferably, the second cavity is detachably combined, combined or connected with the first cavity through the second opening of the liquid connecting channel. Or optionally, the drainage element approaches the first opening of the connecting channel before the sealing element, wherein the first opening is in liquid communication with the first cavity. In some preferred modes, the sealing element and the drainage element are connected as an integral structure or a detachable combination, or in some modes, the sealing element can serve two functions, sealing and drainage are performed simultaneously, and optionally, the drainage element can also serve two functions, sealing the connecting channel while draining. The difference in name here is only the difference in function, and of course both functions can be realized by one component.

In a fifth aspect of the present invention, the device of the present invention may further include a hydrophobic channel, through which the liquid discharged by the liquid discharge element or the sealing element is discharged to the outside of the connecting channel and/or the second cavity. The so-called outside includes the first cavity or other places, such as the receiving cavity. In some preferred embodiments, the sealing element includes a liquid receiving cavity, and the liquid sample discharged from the second cavity enters the receiving cavity of the sealing element through the hydrophobic channel. The "receiving cavity" here refers to the collection of excess liquid discharged by the liquid discharge element or the sealing element, so the receiving cavity can be the first cavity, or other places, such as the space located in the sealing element or the liquid discharge element. In this way, the discharged liquid enters the receiving cavity through the hydrophobic channel. In some preferred embodiments, the hydrophobic channel has one or more liquid inlets, allowing the liquid to enter the receiving cavity through the liquid inlet. In some preferred embodiments, the liquid inlet is located downstream of the first opening of the connecting channel. Alternatively, the hydrophobic channel has one or more liquid inlets, which are located on the sealing element, wherein the liquid inlet is allowed to enter the connecting channel before the sealing element. In some preferred embodiments, after the sealing element seals the connecting channel, the liquid inlet opening of the liquid-repelling channel is located in the second cavity. In some preferred embodiments, the receiving cavity is located in the sealing element. In some preferred embodiments, the liquid inlet of the liquid-repelling channel is located on the wall of the sealing element. In some preferred embodiments, the liquid inlet of the liquid-repelling channel is located at the end of the sealing element.

In some preferred embodiments, the sealing element and the drainage element are connected as an integral structure, wherein the drainage element enters the connecting channel before the sealing element. In some preferred embodiments, part of the drainage element enters the second cavity, and the sealing element seals the connecting channel. Preferably, the sealing element is located in the connecting channel. In some embodiments, the liquid inlet of the lyophobic channel is located between the sealing element and the drainage element, or is located below the sealing element, or is located on the drainage element. In some embodiments, the liquid inlet of the lyophobic channel is arranged at the end of the drainage element, or enters the connecting channel before the drainage element, or enters the second cavity before the drainage element.

In a sixth aspect of the present invention, the present invention provides a first cover body for covering the opening of the first cavity for collecting liquid samples, wherein the sealing element for sealing the connecting channel is connected to the cover body, or the sealing element and the cover body are combined into an integrated structure. In this way, when the first cover body covers the opening of the first cavity, the sealing element also enters the connecting channel to seal the connecting channel. In some preferred embodiments, the first cover body includes a sealing element. In some preferred embodiments, when the first cover body covers the opening of the first cavity, the sealing element connected to the first cover body seals the first opening of the connecting channel. The process of the first cover body covering the opening of the first cavity and the sealing element sealing the first opening of the connecting channel are almost substantially synchronous. Alternatively, when the sealing element is connected to the liquid discharge element as a whole, or the first cover body is provided with a sealing element and a liquid discharge element, the three components can be connected as a whole or can be a detachable combination. In this way, the cover body covers the opening of the first cavity, and the process from covering to completion of covering is also the sealing element sealing the opening of the connecting channel, and the liquid discharge element discharges part of the liquid in the second cavity (if any), and the excess discharged liquid enters the receiving cavity through the liquid-repelling channel.

In some preferred embodiments, the central axis of the sealing element on the cover body and the central axis of the connecting channel are substantially on the same line, so that when the first cover body covers the opening of the first cavity, the sealing element can also seal the connecting channel. In some preferred embodiments, the sealing element is detachably connected to the cover body. In some embodiments, the sealing element is connected to the cover body by a thread. In some embodiments, the sealing element is connected to the cover body through a connecting rod, so that the first cavity has a certain depth. When the cover body covers the opening of the first cavity, the sealing element is located at or near the opening of the connecting channel. When the cover body covers the first cavity, the sealing element connected to the connecting rod enters the connecting channel from the first opening near the connecting channel, thereby sealing the connecting channel.

It is understandable that the sealing element is connected to one end of the connecting rod, and the other end of the connecting rod is connected to the cover body, and the movement of the cover body drives the sealing element to move synchronously, for example, the rotation of the cover body drives the rotation of the sealing element, or the movement of the cover body from top to bottom also drives the movement of the sealing element from top to bottom. It is also understandable that when the sealing element seals the connecting channel by piston-like, the synchronous movement can seal the connecting channel. Of course, if the sealing element and the connecting channel are threaded, the synchronous rotation can also allow the sealing element to seal the connecting channel.

In some embodiments, the present invention provides a first cover body for covering the opening of the first cavity for collecting liquid samples, wherein the first cover body includes a sealing element and a liquid discharge element, or the sealing element and the liquid discharge element are connected to the cover body, or are connected to the cover body as an integral structure. In some preferred embodiments, when the first cover body covers the opening of the first cavity, the sealing element connected to the first cover body seals the first opening of the connecting channel, and the liquid discharge element enters the second cavity. It can be understood that the movement of the first cover body drives the sealing element and the liquid discharge element to move together.

In the seventh aspect of the present invention, in some preferred embodiments, the device of the present invention may further include a second cover body for sealing the opening of the second cavity. In some embodiments, the second cover body is disposed on the second cover body, and when it is necessary to seal the opening of the second cavity, the second cover body is removed from the first cover body to seal the opening of the second cavity. Therefore, in some embodiments, the second cover body is located on the first cover body and is disposed on the first cover body by means of threads, pistons, latches, etc. In other preferred embodiments, the second cover body is detachably disposed on the first cover body, so that the second cover body can be easily removed from the first cover body.

In some preferred embodiments of all the aforementioned embodiments, the second cavity has an opening for collecting liquid samples. In some preferred embodiments, the opening of the second cavity is in liquid communication with the second opening of the connecting channel. In some preferred embodiments, the second cavity is detachably connected to the connecting channel via a thread. In some preferred embodiments, the opening of the second cavity has an internal thread and an external thread, wherein the internal thread is cooperatively connected with the external thread of the connecting channel. The external thread of the second cavity opening is cooperatively connected with the second cover body covering the second cavity opening. Optionally, the second cavity and the second opening of the connecting channel may be detachably connected together in a snap-on manner instead of by a thread.

In some preferred embodiments, the device further comprises a test element, and the test element is in liquid communication with the first cavity. In some preferred embodiments, the device further comprises a detection cavity, and the test element is located in the detection cavity.

In an eighth aspect of the present invention, a method for collecting a liquid sample is provided, and a device for collecting a liquid sample as described above is provided, wherein the device comprises a first cavity for collecting the liquid sample; and a second cavity for collecting the liquid sample for confirmation detection; wherein the first cavity and the second cavity are detachably combined, assembled or connected; allowing the liquid sample to enter the first cavity through the opening of the first cavity, and allowing the liquid sample to enter the second cavity from the first cavity.

In some preferred embodiments, the device includes a connecting channel that allows fluid communication between the first chamber and the second chamber.

In some preferred embodiments, the method provides a sealing element, and after the liquid enters the second cavity, the sealing element is used to seal the connecting channel.

In some preferred embodiments, after the sealing element seals the connecting channel, the second cavity is separated from the first cavity.

In some preferred embodiments, after the second cavity is separated from the first cavity, the opening of the second cavity is covered with a cover.

In some preferred embodiments, the method includes, after the second cavity is separated from the first cavity, the first cavity and the second cavity are not in liquid communication. In some preferred embodiments, after the second cavity is separated from the first cavity, the second cavity is used to store the liquid sample from the first cavity. In some preferred embodiments, when or after the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity. In some preferred embodiments, while the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity.

In some preferred embodiments, the method includes allowing the first cavity and the second cavity to be in liquid communication through a connecting channel. In some preferred embodiments, before the second cavity is separated from the first cavity, the first cavity and the second cavity are in liquid communication through the channel. In some preferred embodiments, after the second cavity is separated from the first cavity or while being separated, the first cavity and the second cavity are not in liquid communication, and the connecting channel is sealed. In some preferred embodiments, after the second cavity is separated from the first cavity, the second cavity stores a liquid sample from the first cavity. In some preferred embodiments, when or after the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity through the connecting channel. In some preferred embodiments, while the first cavity collects the liquid sample, the second cavity also collects the liquid sample from the first cavity through the connecting channel.

In some preferred embodiments, the first cavity includes an opening for collecting a liquid sample, and the liquid sample is allowed to enter the first cavity through the opening. In some preferred embodiments, the connecting channel is connected to the first cavity and the second cavity, so that the liquid sample can exchange liquid between the first cavity and the second cavity through the connecting channel. In some preferred embodiments, the liquid sample can flow from the first cavity to the second cavity through the liquid channel. In some preferred embodiments, the connecting channel has a first opening and a second opening, wherein the first opening is in liquid communication with the first cavity, and the second opening is in liquid communication with the second cavity. In some preferred embodiments, the connecting channel is located on or in the first cavity. The second cavity is detachably connected, combined or combined with the first cavity through the liquid channel.

In some preferred embodiments, the connecting channel has a structure connecting the first cavity and the second cavity and a structure separating the first cavity and the second cavity, wherein the structure connecting the first and second cavities is the space constituting the channel. Alternatively, the connecting channel has two states: sealed and unsealed. When in the unsealed state, the liquid can flow from the first cavity to the second cavity; when the connecting channel is in the sealed state, the liquid in the first cavity cannot flow from the connecting channel to the second cavity.

In some preferred embodiments, the method includes: the device includes a first cover body for covering the opening of the first cavity for collecting liquid samples, wherein the sealing element is connected and combined with the cover body. In some preferred embodiments, the first cover body includes a sealing element. In some preferred embodiments, when the first cover body covers the opening of the first cavity, during or after the first cover body covers the opening of the first cavity, the sealing element connected to the first cover body is allowed to seal the second cavity opening of the connecting channel. In some preferred embodiments, the cover body includes a second cover body for sealing the opening of the second cavity. In some preferred embodiments, the sealing element is detachably connected to the cover body. In some embodiments, the sealing element is connected to the cover body by means of threads.

In some preferred embodiments, the second cavity has an opening for collecting liquid samples. In some preferred embodiments, the opening of the second cavity is in liquid communication with the second cavity opening of the connecting channel. In some preferred embodiments, the second cavity is detachably connected to the connecting channel via a thread. In some preferred embodiments, the opening of the second cavity has an internal thread and an external thread, wherein the internal thread is cooperatively connected with the external thread of the connecting channel. The external thread of the second cavity opening is cooperatively connected with the second cover body covering the second cavity opening.

The above detachable connection mode of the first cavity and the second cavity is detachably connected by the structural design of the connecting channel and the second cavity, and this detachable connection is a direct connection. In some preferred modes, the second cavity can be detachably connected, combined or combined with the first cavity by the connection mode of the channel thread. When the second cavity and the cavity are directly detachably combined, the first cavity and the second cavity are in liquid communication. Preferably, the first cavity and the second cavity are in liquid communication through the connecting channel. In some preferred modes, the opening of the second cavity is in liquid communication with the second opening of the connecting channel. In some preferred modes, the second cavity is arranged on a base, and the base forms a detachable combination with the first cavity. Optionally, the second cavity also forms a detachable combination with the base. In this way, when the base is directly combined with the first cavity, the connecting channel of the opening of the second cavity forms fluid communication. When the base is separated from the first cavity, the second cavity located on the base is separated from the second cavity together with the base. Preferably, when the base is separated from the first cavity, the second cavity located on the base is separated from the connecting channel together with the base. In some preferred embodiments, after the base and the second cavity on the base are separated from the first cavity, the second cavity is separated from the base. In some preferred embodiments, after the second cavity is separated from the base, the opening of the second cavity is covered with a second cover.

In a sixth aspect of the present invention, the present invention also provides a method for collecting liquid samples, the method comprising providing the aforementioned device for collecting liquid samples, the device comprising a first cavity and a second cavity, wherein the second cavity and the first cavity are detachably connected, the first cavity is used to collect the liquid sample, and the liquid sample is allowed to flow into the second cavity.

In some preferred embodiments, when the second cavity collects the liquid sample, the second cavity is separated from the first cavity, and the opening of the second cavity is covered with the second cover.

In some preferred embodiments, the first chamber and the second chamber are connected together through a connecting channel, wherein a first opening of the connecting channel is in liquid communication with the first chamber, and a second opening of the connecting channel is in liquid communication with the second chamber.

In some preferred embodiments, the device further comprises a sealing element, which is used to seal the connecting channel before the second chamber is separated from the first chamber.

In some preferred embodiments, the device further comprises a cover body, wherein the cover body and the sealing element are connected as an integral structure, so that when the cover body covers the opening of the first cavity, the cover body simultaneously drives the sealing element to seal the second opening of the connecting channel.

In some preferred embodiments, the cover body drives the sealing element to enter the connecting channel. In some preferred embodiments, after the sealing element seals the connecting channel, the second cavity is separated from the first cavity.

In some preferred embodiments, a liquid discharge element for discharging part of the liquid in the second cavity is further provided on the cover body, so that the cover body drives the liquid discharge element into the second cavity. In some preferred embodiments, a sealing element and a liquid discharge element are provided on the cover body, so that the liquid discharge element enters the second cavity before the sealing element.

In some preferred embodiments, the device further comprises a lyophobic channel, through which the liquid sample discharged by the liquid discharge element is discharged to the outside of the second cavity. In some preferred embodiments, the sealing element is allowed to enter the connecting channel, and the liquid discharged by the sealing element is discharged to the outside of the connecting channel through the lyophobic channel.

In some preferred embodiments, the liquid discharged by the sealing element or the liquid discharge element is discharged into the first cavity through the liquid-repelling channel. In some preferred embodiments, a receiving cavity is provided on the cover body, and the receiving cavity is in liquid communication with the liquid-repelling channel, wherein the liquid discharged by the sealing element or the liquid discharge element is discharged into the receiving cavity through the liquid-repelling channel.

In a ninth aspect of the present invention, the present invention provides a method for detecting whether an analyte exists in a liquid sample, wherein the method comprises a liquid collection device of any of the above-mentioned methods, and after the first cavity collects the liquid sample, the liquid sample from the first cavity is tested using a test element. After the test result is obtained, the second cavity is separated from the first cavity, and the separation is performed in any of the above-mentioned methods.

In some specific embodiments, the device further includes a detection chamber for accommodating a test element, and the detection chamber is in fluid communication with the first chamber. When the first chamber collects a liquid sample, the liquid flows into the detection chamber. When the detection chamber includes a test element, after the test element completes the test, the second chamber is separated from the first chamber. In some preferred embodiments, the liquid sample is allowed to enter the detection chamber from the first chamber first, and then enter the second chamber. Such a structure is just like the structural design described above, thereby preventing the liquid entering the detection chamber from also entering the second chamber, thereby contaminating the liquid sample in the second chamber.

In the tenth aspect of the present invention, the present invention provides a cover body, on which a sealing element for sealing a connecting channel is provided. In some preferred embodiments, a sealing ring is provided on the sealing element. In some preferred embodiments, the materials of the sealing element and the connecting channel are the same or different. In some preferred embodiments, the sealing element is made of a flexible material, and the connecting channel is made of a rigid material. In some preferred embodiments, the sealing element is connected to the first cover body as an integral structure through a connecting rod. In some preferred embodiments, the sealing element also includes an opening for a lyophobic channel. In some preferred embodiments, the opening of the lyophobic channel is located below the sealing element, or the opening of the lyophobic channel enters the connecting channel before the sealing element. In some preferred embodiments, the cover body also includes a receiving chamber, which is in liquid communication with the lyophobic channel. The receiving chamber is connected to the opening of the lyophobic channel. In some preferred embodiments, the receiving chamber is located in the sealing element.

In some other preferred embodiments, a drainage element is further disposed on the first cover body, and the drainage element is further away from the first cover body than the sealing element. Alternatively, a drainage element is disposed under the sealing element, or the sealing element and the drainage element are disposed such that the drainage element enters the second cavity before the sealing element, or the drainage element enters the connecting channel before the sealing element. Alternatively, a connecting rod is disposed on the cover body to connect the first cover body and the sealing element, and the sealing element is connected to the drainage element. Alternatively, the connecting rod, the sealing element and the drainage element are an integrated structure.

Beneficial Effects

The above structure has the characteristics of simple and reasonable structure, low material cost, excellent performance, and is convenient for secondary detection. In particular, when subsequent confirmation detection is required, it is not necessary to send the entire detection device to the test organization for detection, but only to remove the second cavity from the device and then send it to the detection structure, which is not only safe, but also saves space, saves costs, and is more environmentally friendly.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG1 is a schematic diagram of the exploded structure of a collecting device in a specific embodiment of the present invention.

FIG. 2 is a schematic diagram of the three-dimensional structure of a cover body in a specific embodiment of the present invention.

FIG. 3 is a schematic diagram of the longitudinal section structure of the cover body shown in FIG. 2 in a specific embodiment of the present invention.

FIG. 4 is a schematic longitudinal section of the first cavity in a specific embodiment of the present invention (excluding the detection cavity).

FIG. 5 is a schematic longitudinal section diagram of the second cavity in a specific embodiment of the present invention.

FIG. 6 is a schematic diagram of a three-dimensional structure without a first cover body in a specific embodiment of the present invention.

7 is a longitudinal sectional view of the device shown in FIG. 6 of the present invention, wherein the first cavity and the second cavity are combined together.

FIG8 is a schematic diagram of a partially enlarged structure of the combination of the first cavity and the second cavity in a specific embodiment of the present invention.

FIG. 9 is a schematic diagram of a three-dimensional structure of a first cavity and a second cavity combined in a specific embodiment of the present invention.

FIG. 10 is a three-dimensional structural diagram of the operation process of the first cover body covering the first cavity opening in a specific embodiment of the present invention.

FIG. 11 is a schematic diagram of the three-dimensional structure of a first cover body covering the first cavity opening in a specific embodiment of the present invention.

FIG. 12 is a schematic cross-sectional structural diagram of the device shown in FIG. 11 in a specific embodiment of the present invention.

FIG. 13 is a schematic diagram of a three-dimensional structure in which the second cavity is separated from the first cavity and the second cover is separated from the first cover in a specific embodiment of the present invention.

FIG. 14 is a schematic diagram of the three-dimensional structure of the second cover body covering the second cavity in a specific embodiment of the present invention.

FIG. 15 is a schematic diagram of the three-dimensional structure of a device in another specific embodiment of the present invention.

FIG. 16 is a schematic diagram of the three-dimensional structure of the first cavity in a specific embodiment of the present invention.

FIG. 17 is a schematic diagram of the three-dimensional structure of a test element carrier in a specific embodiment of the present invention.

FIG. 18 is a schematic diagram of the three-dimensional structure of a first cover body with a sealing element in a specific embodiment of the present invention.

FIG. 19 is a schematic diagram of the three-dimensional structure of the first cavity in a specific embodiment of the present invention (without the second cavity).

20 is a schematic diagram of the cross-sectional structure of the combination with the second cavity in a specific embodiment of the present invention (an enlarged schematic diagram of the partial structure of the detachable combination of the first cavity and the second cavity).

21 is a schematic diagram of the three-dimensional structure after the first cover body begins to cover the first cavity opening in another specific embodiment of the present invention (operation process).

FIG. 22 is a schematic diagram of the cross-sectional structure of the device shown in FIG. 21 in a specific embodiment of the present invention (the sealing element does not seal the connecting channel and begins to approach the opening).

FIG. 23 is a schematic diagram of the cross-sectional structure of the device shown in a specific embodiment of the present invention (the sealing element enters the connecting channel).

FIG. 24 is a schematic diagram of a three-dimensional structure in which the second cavity is separated from the first cavity and the second cover is separated from the first cover in a specific embodiment of the present invention.

25 is a three-dimensional structural schematic diagram of the combination process of the second cavity and the first cavity in the detection or collection device in another specific embodiment of the present invention (the second cavity is located in the tray structure).

FIG. 26 is a schematic diagram of the structure of the detection or collection device of the present invention after the first cavity and the tray are combined.

FIG. 27 is a schematic diagram of the cross-sectional structure of the structure shown in FIG. 26 in the detection or collection device of the present invention.

FIG. 28 is a schematic diagram of the structure of the second cover sealing the second cavity in another specific embodiment of the present invention.

FIG. 29 is a schematic diagram of the structure of the second cavity leaving the tray.

FIG. 30 is a schematic diagram of a three-dimensional structure in which a tray having a second cavity is combined with a first cavity.

FIG. 31 is a schematic diagram of the three-dimensional structure of a first cover body with a sealing element in another specific embodiment of the present invention.

FIG32 is a schematic cross-sectional view of the first cover body with a sealing element in another specific embodiment shown in FIG31 of the present invention.

FIG. 33 is a schematic diagram of a three-dimensional structure with a sealing element in another specific embodiment of the present invention.

FIG34 is a schematic diagram of the cross-sectional structure of the structure shown in FIG33 .

35A and 35B are schematic diagrams showing the structures in which the sealing element, the drainage element or the sealing element shown in FIG. 33 are interchanged or one of the components is missing.

FIG. 36 is a schematic diagram of the principle structure of the separation and combination of the first cavity and the second cavity in other specific embodiments of the present invention.

FIG. 37 is a schematic structural diagram of the combination of the first cavity and the second cavity in another specific embodiment of the present invention.

38A and 38B are schematic diagrams of a structure in which the first cavity and the second cavity shown in 37 are separated, and the first cavity is used for secondary confirmation detection.

FIG39 is a schematic diagram of the principle structure of the three-dimensional structure of the first cavity and the second cavity in other specific embodiments of the present invention.

FIG40 is a schematic diagram of the principle structure of the three-dimensional structure in which the first cavity and the second cavity are separated and combined in other specific embodiments of the present invention.

DETAILED DESCRIPTION

The structures involved in the present invention or the technical terms used are further explained below. If not specifically specified, they are understood and interpreted according to the general terms commonly used in the art.

Detection

Detection means to test or examine a substance or material for the presence or absence of a substance or material, such as, but not limited to, a chemical substance, an organic compound, an inorganic compound, a metabolite, a drug or a drug metabolite, an organic tissue or a metabolite of an organic tissue, a nucleic acid, a protein, or a polymer. In addition, detection means to test the amount of a substance or material. Furthermore, assay also means immunoassay, chemical assay, enzyme assay, etc.

sample

The detection device of the present invention or the sample collected includes biological fluid (such as case fluid or clinical sample). Liquid sample or liquid sample can be derived from solid or semi-solid sample, including excrement, biological tissue and food sample. Solid or semi-solid sample can be converted into liquid sample by any appropriate method, such as mixing, mashing, macerating, incubating, dissolving or digesting solid sample by enzymolysis in a suitable solution (such as water, phosphate solution or other buffer solution). "Biological sample" includes samples derived from animals, plants and food, such as urine, saliva, blood and its components, cerebrospinal fluid, vaginal secretions, sperm, feces, sweat, secretions, tissues, organs, tumors, tissue and organ cultures, cell cultures and media derived from humans or animals. Preferably, the biological sample is urine. Food samples include food processed substances, final products, meat, cheese, wine, milk and drinking water. Plant samples include any plant, plant tissue, plant cell culture and media. An "environmental sample" is derived from the environment (eg, a liquid sample from a lake or other body of water, a sewage sample, a soil sample, groundwater, seawater, and a wastewater sample). An environmental sample may also include sewage or other wastewater.

By using the suitable detection element of the present invention, any analyte can be detected. The present invention is preferably used to detect small drug molecules in saliva and urine. Of course, the collection device of the present invention can collect any of the above forms of samples, whether solid or liquid at the beginning, as long as these liquids or liquid samples flow into the first cavity, these liquid samples can flow into the second cavity at the same time or later. Since the second cavity can be detachably combined, combined or connected with the first cavity, when subsequent confirmation detection is required, the second cavity is separated from the first cavity, so that the second cavity can be tested for the second time, and the liquid in the first cavity can be tested for the first time. Optionally, the liquid in the second cavity can be tested for the first time, and the liquid in the first cavity can be tested for the second time.

Optionally, after these liquid samples or processed samples are collected in the first chamber in liquid form, before or after the initial test, the second chamber is used to extract part of the liquid sample in the first chamber for subsequent confirmation test. The first chamber can be combined with the second chamber at the beginning, or they can be combined together when used and then separated.

Downstream and Upstream

Downstream or upstream is divided according to the direction of liquid flow, and generally the liquid flows from the upstream to the downstream area. The downstream area receives liquid from the upstream area, and the liquid can also flow along the upstream area to the downstream area. Here it is generally divided according to the direction of liquid flow. For example, on some materials that use capillary force to promote the flow of liquid, the liquid can flow in the opposite direction of gravity due to gravity. At this time, the upstream and downstream are still divided according to the flow direction of the liquid. For example, in the collection device of the present invention, in some preferred embodiments, the first cavity is used as a cavity for collecting liquid samples, and the second cavity is in liquid communication with the first cavity. The liquid entering the first cavity flows into the second cavity. The first cavity can be called upstream, and the second cavity can be called downstream. Of course, this flow is a natural flow of the liquid under the action of gravity. Optionally, this natural flow is the flow of liquid from the first cavity to the second cavity. Of course, liquid can also flow passively from upstream to downstream. For example, when the liquid is subjected to a reaction force, it is forced to flow from upstream to downstream, or from a low position to a high position. This reaction may be capillary action or external pressure, thereby allowing the liquid to flow from a low position to a high position. The division of upstream and downstream here does not necessarily mean that there must be liquid. It means that when there is liquid, it flows in the order of flow.

Gas connection or liquid connection

Gas connectivity or liquid connectivity means that liquid or gas can flow from one place to another, and some physical structures may be used to guide the flow. The so-called passing through physical structures generally refers to the liquid passing through the surface of these physical structures, or the internal space of these structures and passively or actively flowing to another place. Passive flow is generally caused by external force, such as flow under capillary action. The flow here can also be the liquid or gas due to its own action (gravity or pressure), or it can be passive flow. The connectivity here does not necessarily mean that liquid or gas must exist. It only indicates the connection relationship or state between two objects in some cases. If there is liquid, it can flow from one object to another. This refers to the state of connection between two objects. On the contrary, if there is no liquid connection or gas connection between the two objects, if there is liquid in or on one object, the liquid cannot flow into or on another object. Such a state is non-connected, non-liquid or gas connected.

Detachable combination

A detachable combination refers to a connection relationship between two parts that is in several different states or positional relationships. For example, when there are two parts in a physical sense, they can be separated at the beginning, connected or combined together in a suitable first situation, and can be separated in a suitable second situation. This separation is a physical spatial separation without contact. Alternatively, the two parts are combined together at the beginning, and when appropriate, the two parts can be separated in a physical spatial separation. Alternatively, the two objects are separated at the beginning, combined together to complete a certain function when needed, and then separated, or later combined again for a certain purpose. In short, the combination of the two or the separation of the two can be easily carried out, and this combination or separation can be repeated for many cycles. Of course, it can also be a one-time combination and separation. In addition, it can be a detachable combination between two parts, or a detachable combination between three or more parts. For example, there are first, second and third parts, the first part and the second part are detachable, the second part and the third part can also be a detachable combination, and the first part and the third part can also be a detachable combination or separation. In addition, the combination method can be that the two objects themselves are detachable, or it can be indirectly combined through another object.

Test components

The so-called "test element" here refers to an element that can detect whether a sample or a specimen contains an analyte of interest. This detection can be based on any technical principle, such as immunology, chemistry, electricity, optics, molecular science, nucleic acid, physics, etc. The test element can be a lateral flow test strip, which can detect a variety of analytes. Of course, other suitable test elements can also be used in the present invention.

Various test elements can be combined and applied to the present invention. One form is a test strip. The test strip used to analyze the analyte in the sample (such as drugs or metabolites indicating physical conditions) can be in various forms, such as immunoassays or chemical analysis. The test strip can adopt a non-competitive or competitive analysis mode. The test strip comprises a water-absorbing material with a sample application area, a reagent area and a test area. The sample is added to the sample application area and flows to the reagent area through capillary action. In the reagent area, if the analyte is present, the sample binds to the reagent. The sample then continues to flow to the detection area. Other reagents, such as molecules that specifically bind to the analyte, are fixed in the detection area. These reagents react with the analyte in the sample (if present) and bind the analyte to the area, or bind to a reagent in the reagent area. The marker used to display the detection signal is present in the reagent area or a separate labeling area.

The typical non-competitive assay format is that if the sample contains the analyte, a signal is generated, and if it does not contain the analyte, no signal is generated. In a competitive assay, if the analyte is not present in the sample, a signal is generated, and if the analyte is present, no signal is generated.

The test element can be a test paper, which can be made of absorbent or non-absorbent materials. The test paper can include multiple materials for liquid sample delivery. One material of the test paper can be covered on another material, such as filter paper covered on a nitrocellulose membrane. One area of the test paper can be made of one or more materials, while another area can be made of one or more different materials. The test paper can be adhered to a certain support or hard surface to increase the strength of holding the test paper.

The analyte is detected through a signal generating system, such as by using one or more enzymes that react specifically with the analyte, and by using the method of fixing the specific binding substance on the test paper as described above, to fix the composition of one or more signal generating systems on the analyte detection area of the test paper. The substance that generates the signal can be in the sample addition area, the reagent area, or the detection area, or on the entire test paper, and the substance can be filled with one or more materials of the test paper. A solution containing the signal substance is added to the surface of the test paper or one or more materials of the test paper are immersed in a solution containing the signal substance. The test paper to which the solution containing the signal substance is added is dried.

The various zones of the test strip can be arranged in the following manner: sample addition zone, reagent zone, test zone, control zone, zone for determining whether the sample is adulterated, and liquid sample absorption zone. The control zone is located after the test zone. All zones can be arranged on a test strip using only one material. Different materials can also be used in different zones. Each zone can be directly in contact with the liquid sample, or different zones can be arranged according to the direction of liquid sample flow, with the end of each zone connected to the front end of another zone and overlapping. The material used can be a material with good water absorption such as filter paper, glass fiber or nitrocellulose membrane. The test strip can also be in other forms.

The commonly used reagent strip is a nitrocellulose membrane reagent strip, that is, the detection area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the detection results; it can also be a cellulose acetate membrane or a nylon membrane, etc. For example, the following patents describe reagent strips or devices containing reagent strips: U S 4857453; US 5073484; US5119831; US 5185127; US 5275785; US 5416000; US 5504013; US 5602040; US 5622871; US5654162; US 5656503; US 5686315; US 5766961; US 5770460; US 5916815; US 5976895; US6248598; US 6140136; US 6187269; US 6187598; US 6228660; US 6235241; US The test strips and similar devices with test strips disclosed in the above patent documents can be applied to the test element or detection device of the present invention to detect the analyte, such as the analyte in the sample.

The test strip applied to the present invention can be a so-called lateral flow test strip, and the specific structure and detection principle of these test strips are well-known technologies for those skilled in the art in the prior art. Common test strips include a sample collection area, a labeling area, a test area and a water absorption area, wherein the sample collection area includes a sample receiving pad, the labeling area includes a labeling pad, and the water absorption area can include a water absorption pad, wherein the test area includes necessary chemical substances that can detect whether the analyte is contained, such as an immunoreagent or an enzyme chemical reagent. The commonly used test strip is a nitrocellulose membrane test strip, that is, the test area includes a nitrocellulose membrane, and specific binding molecules are fixed on the nitrocellulose membrane to display the test result; it can also be a cellulose acetate membrane or a nylon membrane, etc., and of course, the test result control area can also be included downstream of the test area, and usually, the control area and the test area appear in the form of horizontal lines, which are test lines or control lines. Such a test strip is a traditional test strip, and of course, it can also be other types of test strips that utilize capillary action to detect. In addition, the general detection reagent strip carries dry chemical reagent components, such as fixed antibodies or other reagents. When encountering liquid, the liquid flows along the reagent strip with capillary action. As it flows, the dry reagent components are dissolved in the liquid, and then processed in the next area to react with the dry reagent in the area, thereby performing necessary tests. The flow of liquid is mainly carried out by capillary action. These test elements are described and recorded in the following documents: "Regeneration of Nitrocellulose Membrane and Study on Its Protein Adsorption Ability" by Li Fugang; "Analysis of Chromatographic Membrane Material Performance in Colloidal Gold Diagnostic Kit" by Ma Hongyan, Li Qiang, etc.; "A New Colloidal Gold Immunochromatographic Test Strip" by Wang Yong, Wang Luhai, etc. They can all be used in the detection device of the present invention, or be arranged in the detection chamber to contact the liquid sample, or be used to detect the presence or amount of the analyzed substance in the liquid sample entering the detection chamber.

In addition to the above-mentioned test strip or the lateral flow test strip itself being used to contact the liquid in the first cavity to test whether the liquid sample contains the substance to be analyzed. In some preferred modes, the test element can also be arranged on some carriers, such as some cards 106, the card has many grooves, the test element is located in the grooves, the entire test card is arranged in the detection cavity 105, and the sample application area of the test element is located at the bottom 1051 of the detection cavity to contact the liquid sample. Such a liquid sample can come from the first cavity 103, for example, the liquid sample is liquid-connected through the through hole 1038 between the detection cavity 105 and the first cavity (for example, as shown in Figures 9 and 1). It is also possible to allow the sample application area of the test element to be located in the sample collection area of the detection cavity to contact the liquid sample, thereby completing the detection of the substance to be analyzed.

In another embodiment, such as shown in FIGS. 16 and 17 , a carrier 206 is provided, on which there are multiple channels with one end sealed 2062 and the other end open 2063. One or more test strips are arranged in the channels, and the sample application area of the test strips is located at one end of the opening 2063. The carrier 206 has one or more channels for accommodating the test strips, and each channel is provided with a test element. When there are multiple channels, test elements of different analytical substances can be provided in each channel, so that multiple analytical substances can be detected using the same sample. This carrier 206 is placed in the first cavity 203, and has two limit strips 2032 and 2033 on the wall of the cavity 203. The carrier 206 is inserted or snapped into the two limit grooves, so that

One end 2065 of the channel with an opening is close to the bottom of the first cavity, and one end 2064 of the sealed channel is close to the opening 2031 of the first cavity (Figure 16). When the liquid sample flows into the first cavity through the opening 2031 of the first cavity, the liquid sample contacts the sample application area of the test strip, thereby completing the detection. Such a carrier is specifically described in the U.S. patent application filed by the applicant, application number 15/644,148, and Chinese patent application numbers 2016106132817 and 2016106079834. Of course, in addition to the carriers disclosed in the above patents, other carriers can also be used in the present invention as carriers for carrying test strips.

For example, in some embodiments, the first cavity may first collect a liquid sample, and then a separate test element may be used to detect the substance to be analyzed in the liquid sample in the first cavity. A test strip or a card or carrier with a test strip is inserted into the first cavity for detection. A person skilled in the art may understand that, according to the present invention, these test strips may not be arranged on a carrier, but exist independently, and the detection cavity 105 of the present invention may be missing in some cases, and the test strip may also be missing in some cases. This will be explained in the detailed description below.

Analyte

Examples of analytes that can be used in the present invention include some small molecules, including drugs (such as drugs of abuse). "Drugs of abuse" (DOA) refer to the use of drugs for non-medical purposes (usually to paralyze nerves). Abuse of these drugs can cause physical and mental damage, dependence, addiction and/or death. Examples of drug abuse include cocaine; amphetamine AMP (for example, Black Beauty, White Amphetamine Pills, Dextroamphetamine, Dextroamphetamine Pills, Beans); methamphetamine MET (crank, methamphetamine, crystal, speed); barbiturates BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey); sedatives (i.e., sleeping aids); lysergic acid diethylamide (LSD); depressants (downers, goofballs, barbs, blue devils, yellow jackets, methaqualone); tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin); MDMA; PCP; tetrahydrocannabinol (THC, pot, dope, hash, weed, etc.); opiates (i.e. morphine MOP or opium, cocaine COC; heroin, hydroxydihydrocodeinone); antianxiety drugs and sedatives and hypnotics. Antianxiety drugs are a class of drugs mainly used to relieve anxiety, tension, fear, stabilize mood, and Drugs with hypnotic and sedative effects include benzodiazepines BZO (benzodiazepines), atypical BZs, fused diazepines NB23C, benzodiazepines, ligands of BZ receptors, open-ring BZs, diphenylmethane derivatives, piperazine carboxylates, piperidine carboxylates, quinazolinones, thiazine and thiazole derivatives, other heterocyclics, imidazole-type sedatives/analgesics (such as oxycodone OXY, methadone MTD), propylene glycol derivatives-carbamates, aliphatic compounds, anthracene derivatives, etc. The detection device of the present invention can also be used to detect drugs that are for medical purposes but are prone to overdose, such as tricyclic antidepressants (imipramine or analogs) and acetaminophen, etc. These drugs will be metabolized into small molecules after being absorbed by the human body. These small molecules exist in body fluids such as blood, urine, saliva, sweat, etc., or some body fluids contain the above-mentioned small molecules.

For example, the analytes detected by the present invention include, but are not limited to, creatinine, bilirubin, nitrite, protein (non-specific), hormones (e.g., human chorionic stimulating hormone, progesterone hormone, follicle stimulating hormone, etc.), blood, white blood cells, sugars, heavy metals or toxins, bacterial substances (such as protein or sugar substances for specific bacteria, such as Escherichia coli 0157: H7, Staphylococcus, Salmonella, Clostridium, Campylobacter, L.monocytogenes, Vibrio, or Bacillus cereus) and substances related to physiological characteristics in urine samples, such as pH and specific gravity. Any other clinical urine chemistry analysis can be detected using the lateral flow detection format in conjunction with the device of the present invention.

Liquid Flow

The flow of liquid usually refers to the flow from one place to another. In general, the flow of liquid in nature mostly relies on the action of gravity to flow from high to low. The flow here also relies on external force, that is, the flow under external gravity, which can be called the flow of natural gravity. In addition to gravity, the flow of liquid can also overcome gravity and flow from low to high. For example, the extraction of liquid, or the compression of liquid, or the liquid receives pressure and flows from the bottom to the high place, or the flow caused by the gravity of the liquid itself due to the concern of pressure. For example, in Figures 9, 19, 22, and 27, the first cavity is located above the second cavity, and the second cavity is located below the first cavity. When liquid enters the second cavity, the liquid can naturally flow from the first cavity to the second cavity by gravity by relying on its own gravity, or it can naturally flow from the upstream to the downstream position.

Detection device or collection device

The detection device refers to a device for detecting whether the sample contains the substance to be analyzed. The collection device refers to the collection and storage of liquid samples. The detection device may include a collection device, and the collection device may also include a detection device, or the collection device is separated from the detection device. When detecting, the collection device and the detection device are combined to complete the detection. It can also be a device with an integrated structure of the collection device and the detection device. Once the liquid sample is collected, the detection can be performed immediately to obtain the test result, and the detection sample and the collection sample are separated at the same time, so that a secondary detection (if necessary) can be performed. The meaning of the detection device or the detection cavity here can be interchangeable, and the collection device and the collection cavity can also be interchangeable, but the functions are different and the functions are interchanged. For example, when the present invention refers to the collection device, it may not include the detection cavity or the test element, but the collection device may include a test element or a carrier containing the test element, and the collection device containing the test element may also be called a detection device. Of course, the collection device may include a space for arranging the test element, but it does not necessarily have to contain the test element. The test element can be combined with the collection device at any appropriate time in the future to become a detection device. For example, the collecting device may include a space for accommodating a test element, such as a detection chamber 105 (FIG. 7), or a suitable position may be provided in the liquid collecting chamber of the collecting device to set a test element or a carrier containing a test element (FIG. 16). Therefore, the present invention may be a device designed only for collecting liquid samples, or it may be a detection device that performs detection simultaneously during collection.

The first cavity and the second cavity are detachably combined, joined or matched

The first cavity and the second cavity of the present invention can form a detachable pair combination, when before the need for liquid collection, the first cavity and the second cavity have been combined together, when the collection of the liquid sample is completed, the second cavity can be separated from the first cavity. Alternatively, the first cavity and the second cavity are separate, and when it is necessary to collect the liquid sample, they are combined together again, and after the collection is completed, the first cavity and the second cavity are separated. In some specific embodiments of the present invention, such as a specific embodiment shown in Figures 1-14, the present invention provides a detection device for detecting whether a liquid sample contains an analyte, or a collection device for collecting a liquid sample, which includes a first cavity 103 and a second cavity 104, and the first cavity 103 can be used as a collection cavity, that is, used to collect liquid samples, wherein the first cavity and the second cavity are combined, connected or assembled in a detachable manner.

The "combination, connection or assembly" here actually means the same thing, only the words used are different, and they can all mean combining together, and this combination is the opposite of "separation". Both combination and separation can be under any conditions and can be freely selected. In some embodiments, when the first cavity and the second cavity are combined together, the first cavity and the second cavity are in a state of liquid circulation. In other embodiments, before or when the first cavity and the second cavity are separated, or after separation, the first cavity and the second cavity are not in a state of liquid circulation.

In some preferred embodiments, the device further comprises a connecting channel, and the first cavity and the connecting channel are detachably joined, combined or assembled. Thus, a detachable grouping, combination or assembly with the second cavity is achieved. As shown in FIG9 , the first cavity 103 is used as a collecting cavity, and it has an opening 1031 for collecting or receiving liquid samples, and the liquid sample flows into the first cavity 103 through the opening. A connecting channel 109 is provided at the bottom of the first cavity, and the connecting channel has a first opening 1091 and a second opening 1092 at the other end. The first opening 1091 of the connecting channel 109 and the first cavity 103 are in liquid flow, and the liquid sample in the first cavity can flow into the connecting channel 109 through the opening 1091, and then flow out through the second opening 1092 at the other end. Therefore, the present invention provides a cavity for collecting fluid samples, wherein the cavity includes an opening 1031 for allowing the fluid sample to enter the cavity 103, and a channel is included at the bottom of the collection cavity, the channel having a first opening and a second opening, and part of the liquid sample can enter the connecting channel through the first opening 1091 of the connecting channel and flow out through the second opening 1090 of the connecting channel. Flowing out means flowing out of the first cavity 103. Preferably, the liquid flowing out of the connecting channel enters the second cavity 104. Therefore, the collection device may also include a second cavity, and generally, the first cavity has an opening, a side wall and a bottom to form a cavity. The connecting channel is generally located at the bottom of the first cavity. In this specific embodiment, the connecting channel is located in the bottom area. However, it is not limited to the position of the connecting channel, and can be located on the side wall or at the junction of the bottom and the side wall. As long as the liquid sample entering the collection cavity 103 can enter the connecting channel, any position is acceptable.

The meaning of "connecting channel" here is generally a structure connecting the first cavity and the second cavity, so that the first cavity and the second cavity are connected or combined together when necessary, and in some cases, the second cavity and the first cavity can be separated. In fact, here, the connecting channel plays two functions at the same time, one is to connect the first cavity and the second cavity in a detachable manner, and the other structure also plays the role of liquid communication between the first cavity and the second cavity, and the liquid can flow between the two cavities through the structure, such as a tube, a groove, or other methods, so the use of "connecting channel" is a preferred embodiment of the present invention. It can be understood that here, in a more preferred solution, the connection and the channel that allows the first cavity and the second cavity to communicate with each other form two different functions for the same structure, such as the tube-shaped structure of the present invention, the connecting channel shown in Figure 9 or Figure 9 and Figure 4 has a structure that connects the second cavity to the first cavity and also plays a state of liquid communication. It can be understood that the mechanism of the connecting channel can be defective, and there will be a detailed description in other embodiments later. Of course, the "connection channel" here can also be understood as only having a connection function, allowing the second cavity and the first cavity to be connected or combined in a detachable manner, but not having the function of allowing the second cavity and the first cavity to communicate with each other liquid; optionally, the "connection channel" here can also be understood as only having a function of allowing the second cavity and the first cavity to communicate with each other liquid, but not having the function of connecting the first cavity and the second cavity. Optionally, the "connection channel" here can also be understood as described above, that is, having the function of connection and also having the function of allowing liquid to communicate.

In some preferred embodiments, an external thread is provided on the outside of the second opening of the connecting channel. A second cavity 104 is provided, and the second cavity 104 has an opening 1042. The second opening 1042 is equal to or slightly larger than the outer diameter of the connecting channel, and an internal thread is provided on the inner side of the opening of the second cavity 104. In this way, the second cavity and the first cavity can be detachably matched, combined or connected by the cooperation of the external thread of the connecting channel and the external thread of the second cavity. That is, when the combination is performed, the second cavity is directly connected to the connecting channel by a thread; when it is necessary to disassemble, the second cavity 104 is separated from the connecting channel in the form of a reverse thread, thereby separating from the collecting cavity 103. Alternatively, an internal thread is provided in the second opening 1092 of the connecting channel, and an external thread is provided on the outside of the opening 1042 of the second cavity 104. The internal thread of the channel opening cooperates with the external thread of the second cavity, so that the first cavity and the second cavity are assembled or connected in a removable manner. When the second cavity is separated from the first cavity, the second cover body is used to cover the opening 1042 of the second cavity, thereby sealing the second cavity.

Of course, optionally, as shown in FIG. 9 , the outer wall of the second opening 1092 of the connecting channel has no threads, but a narrow space 1098 is set on the outer wall of the second opening 1092 of the connecting channel 109, and the narrow space can just cooperate with the opening of the second cavity 104, that is, it cooperates with the thickness of the opening of the second cavity. For example, the narrow space is composed of the outer wall 1905 of the second opening 1092 of the connecting channel and the corresponding wall 110 (for example, as shown in FIG. 8 ), and a threaded structure is set on the wall 110, and the threaded structure cooperates with the external thread at the opening 1042 of the second cavity 104, so that the external thread of the second cavity can cooperate with the thread on the wall 110, thereby realizing the combination of the first cavity and the second cavity, and this combination is also completed by the inner wall of the second cavity opening and the outer wall of one end 1092 of the connecting channel. The second cavity 104 and the first cavity 103 are in a detachable fit, combination or connection. In order to make the first cavity and the second cavity have a better sealing fit relationship, there can be a threaded structure on the inner side of the opening of the second cavity.

The second sealing ring 107 allows the inner wall of the opening of the second cavity to fit more closely with the outer wall of the connecting channel, thereby preventing the liquid sample entering the second cavity 104 from leaking (as shown in FIGS. 8 and 9 ). A person skilled in the art should understand that the so-called "detachable" here means that the two objects can be combined together to form an integral structure when needed, and when the two objects need to be separated, they can be easily separated, and this separation is mainly non-contact in the spatial structure in the physical sense.

In addition to the threaded connection, this detachable method can also be connected in any other way, such as a snap-on connection, a piston connection, a plug-in connection, a lock connection, etc., as long as the first chamber and the second chamber can be combined and connected together when needed, so as to obtain part of the liquid sample from the first chamber, and separate the first chamber and the second chamber when they need to be separated. For example, the threaded connection is to rotate in opposite directions to separate from the first chamber; or in other ways, such as extraction or unlocking, the second chamber 104 can be easily separated from the second chamber after obtaining the liquid sample from the first chamber. This way of obtaining liquid allows the first chamber 103 and the second chamber 104 to maintain liquid communication when they are connected.

Of course, in a specific embodiment, which is also a preferred embodiment, the connecting channel 109 and the first cavity 103 are injection molded at one time, and the second cavity 104 is another injection molded, and the second cavity is detachably combined, joined or combined with the connecting channel. It is understandable that the connecting channel 109 and the second cavity 104 are injection molded at one time, and the connecting channel 109 and the second cavity 104 are detachably combined, joined or combined with the first cavity 103.

Therefore, the so-called "connection" function itself can be completed by a separate structure, and the liquid communication state between the first chamber and the second chamber can be completed by another structure. This method is also easy to understand. For example, the first chamber and the second chamber are connected together in a detachable manner through a connecting mechanism, and the liquid cannot flow between the second chamber and the first chamber through the connecting mechanism itself, but through another structure, such as a channel, to allow the liquid to flow from the first chamber to the second chamber. Therefore, it can be understood that in some preferred methods, the device also includes a connecting structure, and the first chamber and the second chamber form a detachable connection, combination or assembly through the connecting structure, and when connected through the connecting structure, the first chamber and the second chamber are in a liquid flow state. Here, the liquid flow can be placed in a liquid flow state through another structure, such as a tube, a channel, or a groove.

It can be understood by those skilled in the art that the connecting channel 109 here can be omitted. As long as the first cavity is allowed to collect liquid samples, the liquid samples can be allowed to flow into the second cavity connected to the first cavity, and when the second cavity needs to be separated from the first cavity, it is easy to separate the second cavity from the first cavity. Such a method can be other suitable methods that can be thought of by those skilled in the art after seeing the essence of the present invention. For example, as shown in FIG. 36, a hole 903 is provided on the side wall of the first cavity 903, and the hole is initially sealed by an easily punctured film or a self-sealing silicone, rubber, or soft plastic seal. When it is necessary to collect samples, the first cavity 903 is used to collect samples. After the liquid samples are collected, a second cavity 904 (not initially connected to the first cavity) is provided, and the opening of the second cavity is allowed to puncture the sealing film (not shown) on the first cavity, so that the liquid in the first cavity flows into the second cavity, and then is separated from the first cavity again, so that the liquid in the second cavity is used for secondary detection. For another example, as shown in Figs. 37-38, the first cavity and the second cavity are not detachably combined through a connecting channel, but the first cavity and the second cavity are detachably combined through mutually matching thread structures. For another example, as shown in Figs. 25-27, the detachable combination is performed through a tray structure, which will be described in detail below.

Optionally, referring to FIG8 , the present invention designs a connecting channel 109 to connect the opening 1042 of the second cavity 104. Of course, the connecting channel 109 may not be needed, but the opening 1042 of the second cavity 104 may be used as the connecting channel, and the opening 1042 of the second cavity may be directly connected to the interior of the first cavity. This connection may be in the form of a snap connection, a piston type, or a lock. At this time, the bottom of the first cavity has a hole. As long as the opening 1042 of the second cavity corresponds to the hole, the liquid can flow from the first cavity to the second cavity. Preferably, the first cavity and the second cavity are connected together before the first cavity collects the sample. When the second cavity needs to be separated from the first cavity, it is feasible to conveniently separate them.

In some other preferred embodiments, the detachable connection, combination or combination of the first cavity and the second cavity is not a direct detachable connection of the first cavity and the second cavity without another structure as shown in FIG. 33, nor is it an indirect detachable connection of the first cavity and the second cavity through a connecting channel as shown in FIGS. 8-9, 1, 22-23, but a detachable connection or combination as shown in FIGS. 25-30. The following is a detailed description.

Therefore, another aspect of the present invention provides a collection or detection device, which includes a first cavity for collecting liquid samples; and a second cavity for confirming secondary detection, wherein the device also includes a tray structure, which is detachably combined, combined or assembled with the first cavity. In some embodiments, the second cavity is located on the tray, that is, the detachable combination or combination between the second cavity and the first cavity is indirectly achieved by the detachable combination or combination of the tray and the first cavity, that is, the tray structure and the second cavity are carried out in a linkage manner, and the linkage here is generally that the movement of the tray drives the movement of the second cavity, thereby achieving separation from the first cavity, and then after the linkage, separation or non-separation from the tray structure can be achieved.

At this time, the connecting channel may or may not have it, so the connecting structure is not necessary. For example, as shown in Figures 25-30, the second cavity is located on a base structure or a tray structure 1004, and the opening of the second cavity is still connected to the connecting channel liquid (having a connecting channel), but it is not necessary to rely on the second cavity and the connecting channel to rely on their own structure to directly connect to achieve liquid conduction as described above. In this specific embodiment, it is only necessary for the opening of the second cavity to be joined together with the second outlet of the connecting channel, and the base structure 1004 and the bottom of the first cavity 103 are joined together through a matching structure (Figure 27), and this matching structure is in the form of a thread. In this way, the base structure has a thread, such as an external thread, and the bottom of the first cavity has an internal thread. The two are combined together in the form of a thread, and the second cavity and the connecting channel are tightly matched through the binding force of the thread. Specifically, the following manner: for example, as shown in FIGS. 25-28, the second cavity 304 is located on a base tray 1004, and the base tray 1004 is detachably connected to the first cavity, and the second cavity 304 is also detachably combined with the base tray 1004. Specifically, the tray structure 1004 has an internal thread, and the internal thread cooperates with the external thread 3031 extending from the bottom of the first cavity 303, so as to realize the detachable combination of the tray structure 1004 and the first cavity 303. In this way, if there is still a connecting channel, as shown in FIG. 27, the connecting channel 309 can still have a first opening 3091 in liquid flow with the first cavity and a second opening 3092 in liquid flow with the second cavity, and the connecting channel has an extension section 3098, which extends deep into the opening 3052 of the second cavity, contacts with the inner wall of the opening 3041, and can be snapped together, that is, the outer diameter of the extension area matches the inner diameter of the opening 3041. Although the second cavity and the first cavity can also be connected by the connecting channel 109 as shown in Figure 27, this connection does not need a very strong connection, and does not need a tight connection like Figures 8-9 (through threads, etc.), because the tray structure 1004 cooperates with the external thread 3031 of the extension section of the first cavity 103 through the thread 10041, so that no matter how much liquid sample is collected by the second cavity 304, it will not cause leakage between the connecting channel 109 and the second cavity opening 1042. Therefore, the inner diameter of the connecting channel 109 can be smaller than the inner diameter of the opening 1042 of the second cavity, so that the connecting channel can be inserted into the opening 3042 of the second cavity, and this insertion method can be easily inserted (as shown in Figure 27). Only the outer edge of the opening 3042 is provided with a thread for the second cover body to cover (as shown in Figure 27). At this time, the connection between the connecting channel and the opening of the second cavity only needs to ensure that there is no leakage when collecting liquid samples, that is, it can allow the liquid to enter the second cavity, without more structural restrictions. This connection can be in the form of a snap connection, a piston type, or a lock. In fact, the detachable combination, connection or engagement of the first cavity and the second cavity is achieved in an indirect manner.

After the collection is completed, the connection channel is sealed and/or the second cavity is drained according to the method described below. If a second confirmation test is required, the lower tray structure 1004 is separated from the first cavity 103, for example, by reversely rotating the tray and cooperating with the thread structure at the bottom of the first cavity. At this time, the second cavity 104 located on the tray is also separated from the first cavity 103 along with the tray structure, as shown in Figure 27. At this time, the second cover 101 is removed to cover the opening 3042 of the second cavity. Then the second cavity is separated from the tray 1004 (as shown in Figure 29). This is because the bottom of the second cavity and the bottom of the tray have a snap-fit structure 10042, so the tray and the second cavity will be separated from the first cavity 103 together. Then, after removing the tray 1004 from the second cavity 304, the tray 1004 is reconnected and combined with the first cavity 103 separately. At this time, the integrity of the first cavity is still maintained, and the second cavity can be sent to the confirmed testing agency for a second confirmation test. In order to allow the second cavity 304 to be separated from the first cavity as the tray moves, a snap ring 10042 is provided on the tray, and the shape of the snap ring is adapted to the shape of the second cavity 304. For example, the second cavity is U-shaped, and the snap ring 10042 is also U-shaped. In this way, when the tray structure 1004 rotates, the second cavity 304 is driven to rotate together. Since the second cavity and the snap ring can be slightly closely matched, the second cavity 304 and the tray structure 1004 are naturally separated from the first cavity 303. Of course, in some embodiments, the second cavity is a structure similar to a cube, and four snap structures are provided on the tray to snap the second cavity and the snap structures together, so that the movement of the tray drives the movement of the second cavity, and then the second cavity is separated from the first cavity.

At this time, in order to ensure the safety of the second cavity after being covered by the second cover, a seal can be affixed to the second cavity, and the seal covers the second cover and part of the second cavity. Ensure that the sample in the second cavity is not maliciously replaced, and keep the liquid in the second cavity consistent with the original sample in the first cavity. Of course, optionally, the tray 1004 and the second cavity can be packaged and transported together, and the seal covers the second cavity and the tray and the cover that seals the second cavity, so as to form an integral structure for transportation. It is also understandable that the base structure 1004 and the second cavity 104 are an integral structure, which is a one-time injection molding structure. In this way, when the base 1004 is combined with the first cavity 104, the second cavity 104 is also combined with the connecting channel 109.

Optionally, the connecting channel and the extension section 3098 here can be omitted. This is because only a hole needs to be opened at the bottom of the first cavity 103, and the size of the hole is smaller than or equal to the opening 3042 of the second cavity 304. The connecting channel does not need to have an extension section (as shown in Figure 27). The first opening 3091 of the connecting channel can play the function of the bottom hole. In this way, when the second cavity is combined with the first cavity through the tray, the opening 1042 of the second cavity corresponds to the bottom opening of the first cavity 103 (similar to the position of 3091 shown in the figure). By relying on the cooperation between the tray 1004 and the first cavity 303, the opening of the second cavity 304 forms a close fit with the area around the hole, or forms a close contact, so that the second cavity and the first cavity form a liquid flow state. When the first cavity collects liquid, the liquid will also flow into the second cavity. If the first cavity 103 needs to be separated from the second cavity, the hole at the bottom of the second cavity (similar to the position of 3091 shown in FIG. 27 ) is sealed, so that the tray 1004 is separated from the first cavity 103, and the second cavity 103 is also separated from the first cavity. The same function is achieved. Optionally, the hole is initially sealed with an easily punctured sealing material, and after the liquid is collected or the detection is started, the sealing material is punctured to allow the liquid to flow into the second cavity. The method of the sealing element will be described in detail later.

After the collection of liquid in the first chamber is completed, the second chamber can be separated from the first chamber, so that the second chamber can be stored or transported to the detection agency for secondary confirmation testing, and the liquid in the first chamber can be used for the first or initial test. Alternatively, after the collection of liquid in the first chamber is completed, the second chamber can be separated from the first chamber. After separation, the liquid in the first chamber is initially tested, and after the test results are obtained, the separated second chamber can be stored or directly sent to the detection structure for a second confirmation test. Alternatively, after the collection of liquid samples is completed, the liquid sample in the first chamber is tested, and after the initial test results are obtained, the second chamber is separated from the first chamber, and the separated second chamber is used for storage or subsequent second confirmation testing.

Of course, the liquid in the first cavity can be stored and the initial test can be performed at an appropriate time. In some preferred embodiments, it is hoped that after the liquid in the first cavity is collected, the corresponding initial or first test is performed at the same time. After the test results are completed, for some of the initial test results, if necessary, a secondary confirmation test is performed. Once, the initial test is only a preliminary test to determine whether there is still the analyte in the sample, and the sensitivity of the test generally does not need to be very high. Sometimes, when the analyte in the sample is at a critical threshold, the result of the initial test cannot give a positive or negative result. At this time, it is hoped that a secondary confirmation test is performed on the same part of the sample.

As for whether the second cavity or the first cavity is used to confirm the secondary detection after the first cavity and the second cavity are separated, for example, the first cavity can be used for the secondary detection, and the liquid sample in the second cavity can be used for the initial detection, which can be realized. Therefore, the first cavity and the second cavity do not limit that only the second cavity can be used for confirmation detection. In some ways, such as shown in Figures 37 and 38, the present invention provides a first cavity 603 for collecting liquid samples and a second cavity 604 for performing initial detection, the second cavity has a detection cavity 605, and the detection cavity and the second cavity have a liquid connecting through hole 6038. The first cavity has an opening 6031, and a connecting channel 609 is provided at the bottom of the first cavity, the connecting channel has a first opening 6091 and is connected to the first cavity liquid, and has a second opening 6092, wherein the first opening is sealed by a sealing element, and the sealing element is a sealing element pierced by the shell, such as a film, double-sided tape, aluminum foil, etc. In this way, when the first cavity is used to collect the liquid sample, the liquid will not flow out through the first opening of the connecting channel at the beginning. After the first cavity collects the liquid sample, it is combined with the second cavity, for example, by using the external thread 6031 of the first cavity and the internal thread of the second cavity, or, at the beginning, the first cavity and the second cavity are already combined together by threads, and the first cavity 603 is used to directly collect the liquid sample. When the collection is completed, the sealing element with the seal 6028 and the piercing element 6029 is used to pierce the first opening of the sealing connection channel, and the liquid is released to the second cavity 604 for the initial detection. The liquid enters the detection cavity 605 for the initial test. When the second confirmation test is required, the first cavity is disassembled from the second cavity, and the opening of the first cavity is sealed with a cover body, so that the liquid sample in the first cavity is subjected to the second confirmation test. In an optional manner, the cover body used to seal the first cavity includes the sealing element 6028 and the piercing element 6029, and the first cavity has an extended channel 610 corresponding to the first opening 6091 of the connecting channel 609, and the channel extends into the first cavity, so that when the cover body covers the first cavity, the cover body and the sealing element 6028 and the piercing element 6029 form a linkage relationship, so that the sealing element and the piercing element move together, and when the piercing element pierces the first opening 6091 of the sealed connecting cavity, the sealing element pushes the liquid in the channel 610 to flow into the second cavity for the initial test, and at this time the cover body seals the opening of the first cavity. As shown in the upper figure of Figure 38. When it is necessary to confirm the second test, the first cavity 603 is separated from the second cavity 604, and then the second opening of the connecting channel is sealed with the second cover body, such as a threaded manner, and then the first cavity 603 is sent to the detection mechanism for secondary confirmation detection, as shown in the lower figure of Figure 38.

Of course, the piercing element can also have the function of draining part of the liquid in the second cavity. In this case, the piercing element can also have a hydrophobic channel, a liquid inlet, and a receiving cavity. In this way, after piercing the first opening 7091 of the sealing connection channel, the piercing element is directly partially inserted into the second cavity. In order to drain the liquid, the liquid can be allowed to flow into the receiving cavity through the liquid inlet of the hydrophobic channel. For example, the receiving cavity is located in the piercing element. This can be clearly understood and combined with the detailed description below.

In some optional embodiments, when used as a detection device, the collection device also includes a test element, which can test the collected samples. For example, the collection device includes a detection chamber, wherein the detection chamber is in liquid communication with the first collection chamber, that is, the liquid sample located in the first chamber can flow into the detection chamber. Of course, the detection device here including the detection chamber is only a preferred embodiment. When used as a collection device, the detection chamber may be absent, or the detection device includes the detection chamber but does not have a test element. When testing is needed, the detection element is inserted into the detection chamber. In some specific embodiments, a detection chamber 105 is provided outside the side wall of the first chamber, and the first chamber 103 and the detection chamber 105 are in liquid communication (as shown in FIG. 9).

If there is a liquid sample in the first cavity 103, the liquid can be connected to the detection cavity 105 and the through hole 1038 provided in the collection cavity 103, thereby entering the detection cavity for necessary initial testing or detection.

Generally, the sensitivity of the detection of the liquid sample in the first cavity 103 (first or initial detection) is not as high as the sensitivity of the secondary confirmation detection, or the specificity of the first or initial detection is not as accurate as the specificity of the secondary confirmation detection. In this way, the secondary detection can basically confirm whether the initial detection is true and accurate. For example, the initial detection is carried out by immunological and chemical methods, while the secondary confirmation detection generally adopts mass spectrometry (GS), gas phase or liquid chromatography detection. This secondary detection is generally carried out with a liquid sample in a second cavity separated from the first cavity. This is because the first cavity and the second cavity are both for the same sample, and their properties are the same, but they are only divided into different parts. The second detection can confirm the initial detection.

In some preferred embodiments, the liquid in the first cavity is tested immediately while the first cavity 103 collects the liquid sample or within a short time after the collection is completed. Therefore, in a preferred embodiment of the present invention, the first cavity 103 and the detection cavity 105 are in liquid communication, and the detection cavity includes a test element. In some preferred embodiments, these test elements are arranged on a carrier. In a preferred embodiment, the detection cavity includes a test carrier 106, and there are many card slots 1061 on the test carrier, and a test element is arranged in each card slot. For example, as shown in Figure 9, when the liquid sample is collected in the first cavity 103, a part of the liquid sample flows into the detection cavity 105 through the through hole 1038, and the liquid sample flowing into the detection cavity contacts the test element, thereby completing the detection of the substance to be analyzed; another part of the liquid sample flows into the second cavity 104 through the opening 1091 of the connecting channel 109. After the test element in the test chamber has finished testing, the initial test result is read. After reading, if it is necessary to conduct a second test for confirmation, the second chamber 104 is separated from the first chamber 103, and the opening 1042 of the second chamber 104 is sealed with the second cover 101. The second chamber 104 is stored or directly sent to the confirmation test structure for further confirmation testing. The liquid in the first chamber 103 and the test chamber 105 for the initial test can be discarded or processed.

The method of separating the first detection and the second confirmation detection is adopted, which overcomes some disadvantages of traditional detection equipment. In traditional detection devices, after the test is completed, if a second test is required, the entire detection device (with the first cavity as a cavity for collecting liquid and/or with a detection cavity, or a test element in the detection cavity) needs to be stored, or the entire detection device needs to be packaged and transported (by land, sea or air) to a secondary testing agency for confirmation testing. This requires guaranteeing or ensuring that there is no leakage of liquid samples in any structure or any place of the entire detection device, because once the sample leaks, it will cause external contamination, and the samples will also contaminate each other, bringing uncertain results to the confirmation or secondary detection. This is bound to seal and package each structure that may cause leakage, which adds a lot of cost and design difficulty to the manufacture of such detection devices, because these first detection devices are generally plastic products and are disposable. It is difficult to achieve that such devices will not cause liquid leakage under any circumstances. Even if it can be guaranteed that there is no leakage, the manufacturing cost is indeed very high. Ideally, on the one hand, the cost is reduced as much as possible, and at the same time, it is necessary to ensure that the liquid sample does not leak, which brings great challenges to the manufacturer. For example, this requires a complex design of the first cover 102 that seals the opening 1031 of the first cavity to ensure that the liquid cannot leak out through the opening 1031. If the device also includes a test element, this requires a more precise processing or design of the cavity (if any) that accommodates the test element to ensure that the liquid sample cannot leak out through the test cavity. In particular, these devices generally need to be transported by air and do not leak under negative pressure or high pressure, which brings great challenges to manufacturing and design. Traditionally, sealing rings or silicone pads are always used as sealing components to avoid leakage, but once the device is stored for a long time, these silicones or plastics will be oxidized or aged, causing liquid leakage when used. Second, if it is necessary to save the samples of the initial test results, more storage space is also required to accommodate large-volume test devices; this will inevitably increase more space, especially for professional testing institutions, the number of samples tested is very large, which requires sufficient space to store these samples that have been tested for the first time. These samples that have been tested for the first time are contained in a relatively large test device, requiring a larger area or volume for the storage space. Third, the large size of the devices that have completed the initial test significantly increases the transportation cost, which increases the cost of transportation packaging. After all, traditional detection devices are large in size and are packaged and transported separately. Fourth, if the detection device has a test element at the beginning, the collected liquid is always in contact with the test element during transportation. The test element contains chemical substances that are not present in the liquid sample itself. The liquid sample is allowed to contact with the test element for a long time, causing contamination of the liquid sample, which may have a negative impact on the subsequent secondary detection. In short, no matter what the reason, the traditional detection device or collection device has one or more of the defects described above.

With the device of the present invention, the volume of the second chamber is generally smaller than that of the first chamber, even only one tenth or one fraction of that of the conventional detection chamber. The second chamber generally only needs 1-50 ml of sample to perform secondary analysis, for example, 0.1 ml, 0.2 ml, 0.3 ml, 0.4 ml, 0.5 ml, 0.6 ml, 0.7 ml, 0.8 ml, 0.9 ml, 1 ml, or only 1.2 ml, 1.4 ml, 1.6 ml, 1.8 ml, 2 ml, or only 3 ml, 4 ml, 5 ml, 6 ml, 7 ml, 8 ml, 9 ml, 10 ml, 11 ml, 12 ml, 15 ml, 25 ml, 30 ml. The volume of the first chamber is generally 5-500 ml, for example, 8 ml, 10 ml, 12 ml, 14 ml, 16 ml, 18 ml, 20 ml, 22 ml, 24 ml, 26 ml, 28 ml, 30 ml, 32 ml, 34 ml, 36 ml, 38 ml, 40 ml, 42 ml, 44 ml, 46 ml, 48 ml, 50 ml, 60 ml, 70 ml, 80 ml, 100 ml, 150 ml, 200 ml, 250 ml, 500 ml. In addition, generally, the second chamber has only one opening 1042, and as long as the second opening 1042 is sealed, it can be confirmed that the sample is not leaked. On the one hand, the second chamber is small in volume and light in weight, so that the transportation packaging cost is significantly reduced and the storage space is very small. On the other hand, there is no need to have the same high sealing requirements for the first cavity and/or the components containing the detection cavity as the traditional device. For example, the sealing requirements for the first cover body to seal the opening 1031 of the first cavity are much lower, and the sealing requirements for the detection cavity set by the test element are also much lower than the traditional ones. It is even possible to ignore whether the first cover body has a sealing effect on the opening of the first cavity 103, and it is also unnecessary to consider the sealing effect of the detection cavity itself. This is because once the initial detection is completed, the first cavity 103 and/or the first cavity with the test cavity 105, and even the first cover body 102 can be discarded. Compared with the traditional disposable detection device, a lot of costs are saved and it is safer and more reliable. In addition, since the properties of the liquid in the second cavity are consistent with those of the first cavity, the effectiveness of the secondary detection is guaranteed. Third, due to the small volume of the second cavity, there is no need to consider the storage space. A large number of second cavities can be stored in a very small place, which reduces the pressure on the confirmation laboratory, reduces the transportation cost, and ensures the safety of transportation. Because there is no need to worry too much about the risk of liquid leakage.

In some preferred embodiments, when the liquid sample collected in the first cavity 103 needs to be tested and the secondary confirmation sample needs to be collected in the second cavity 104 at the same time, it is hoped that the sample flowing into the detection cavity (if there is a detection cavity) will not cause potential contamination to the liquid sample entering the second cavity 104, so that the position of the opening 1091 of the connecting channel 109 is higher than the height of the through hole 1038 (for example, as shown in Figures 7 and 6, as shown in Figure 9), so that the liquid flowing into the detection cavity will not or almost cannot enter the second cavity, thereby ensuring that the liquid in the second cavity 104 is substantially the same as the liquid sample that has not been in contact with the test element. After all, the liquid sample in contact with the test element may contain some chemical reagents or other components processed on the test element. If such reagents or components enter the second cavity, it may have an adverse effect on the second test result. It can be understood that the opening 1091 with the connecting channel is higher than the through hole 1038, or according to the aforementioned method, the opening through which the liquid flows into the second cavity is higher than the position of the through hole that flows into the detection cavity (for example, the bottom hole in the aforementioned embodiment, which does not have a connecting channel at this time), which can prevent the liquid sample in contact with the test strip from entering the second cavity when the test element is included in the device and in contact with the liquid sample.

In some preferred embodiments, the first cavity contains a collection area 1035 or 1036 for collecting liquid, and these collection areas are located at the bottom of the first cavity 103, around the connection channel 109 or around the first opening 1091 of the connection channel. In some preferred embodiments, the positions of these collection areas are lower than the positions of the connection channel opening 1091, so that when the liquid enters the first cavity, it first collects in the collection area, and then enters the detection cavity through the through hole 1038 to contact the test element. Therefore, according to the order in which the liquid arrives, the liquid first arrives in the collection area, then flows into the through hole 1038 to enter the detection cavity (if any), and then reaches the position of the first opening 1091 of the connection channel.

In some preferred embodiments, for example, as shown in Figures 12, 4, and 5, there is a raised area in the middle of the bottom of the first cavity, and the space formed by the raised area is used to accommodate part of the main structure of the second cavity 104. A connecting channel or hole is set on the raised area, and the raised area also forms a collection area u (as shown in Figures 4 and 5). From the bottom of the first cavity (for example, Figure 4), the bottom is recessed into the first cavity 103, and this recessed area is used to accommodate part of the area including the opening 1042 of the second cavity 104. In this way, from the overall point of view, the material of the detection device will not be additionally increased, and it will not appear abrupt. As described in Figures 7-11, the opening part of the second cavity is set under the bottom of the first cavity 103, and from the overall point of view, it is still the same as the traditional detection device. In some preferred embodiments, the positions of the collection areas 1036 and 1035 are lower than the position of the through hole 1038, so that the collected liquid sample first enters the detection chamber (if any) 105 through the through hole 1038. Once the detection chamber is filled or the through hole 1038 is sealed by the liquid, the excess liquid will enter the second chamber 104 through the first opening 1091 of the connecting channel 109. In this way, the liquid flowing into the detection chamber is prevented from entering the second chamber from the detection chamber. Alternatively, in terms of the order of liquid flow, the liquid generally reaches the collection area first for collection, and after being collected to a certain height, it flows into the detection chamber through the through hole 1038 for testing and analysis. After the detection chamber collects the liquid sample, the through hole 1038 will be sealed by the liquid. As the amount of liquid increases, the liquid level will reach the position of the connecting channel opening 1091, thereby entering the second chamber, filling the second chamber or part of the liquid sample entering the second chamber as a subsequent secondary confirmation test.

In some other embodiments, the detection device does not contain a separate test cavity (as shown in FIG. 1 ), for example, as shown in FIG. 15-17 , a region is included on the side wall of the first cavity 203 , for example, as shown in FIG. 16 , the first cavity 203 includes two vertical clamping strips 2032 and 2033 , and the two clamping strips restrict such a region, allowing the carrier shown in FIG. 17 to be inserted into the region, forming a structure with a test function. For example, as shown in FIG. 17 , the carrier is provided with a plurality of channels 2063 for accommodating test elements, one end 2062 of the channel is closed, and the other end 2061 is open, each channel is arranged on the carrier in such a compatible direction, the detection area and the water absorption area on the test element are located in the channel, and the sample application area on the test element is located at one end of the channel opening 2063, and the test element in each channel is arranged in such a way that the sample application area of the test element in each channel is located at the end 2065 of the carrier, and correspondingly, the detection area of the test element is located at the end close to the channel seal, which is located at the top 2064 of the carrier. When the carrier is assembled into the first cavity 103, the end 2065 of the carrier is close to the bottom 2034 of the first cavity, and the top 2064 of the carrier is close to the opening 2031 of the first cavity. In this way, part of the liquid sample entering from the opening of the first cavity 203 contacts the sample application area of the test element near the bottom 2034 of the first cavity 203, thereby completing the test of the analyzed substance in the liquid sample. In some other preferred embodiments, such as shown in Figures 25-30, the detachable combination of the second cavity 304 and the first cavity 303 can be realized in the manner described above, such as in Figures 1, 6-13, or in any of the aforementioned methods, including any subsequent methods for sealing or separation.

In some preferred embodiments, the bottom 2034 of the first cavity has a groove 2035 structure, and the groove structure 2035 allows the liquid sample to be collected in the first cavity, as shown in Figures 22 and 23. In some preferred embodiments, the height of the first opening 2091 of the connecting channel 209 is higher than the height of the groove, that is, the opening 2091 of the connecting channel 2091 is located upstream of the groove 2035, so that the liquid sample in contact with the test element and near the groove can be prevented from flowing into the second cavity 204 through the first opening 2091 of the connecting channel 209. Similarly, when the test element in the carrier located in the first cavity completes the initial or first test, if it is considered necessary to perform a subsequent secondary confirmation test, the second cavity can be directly separated from the first cavity, and after separation, the opening 2041 of the second cavity 204 is sealed with the second cover 201 for separate storage, or it can be separately packaged and transported to the second confirmation test structure for confirmation test. Correspondingly, the carrier 206 that has completed the initial inspection and the first cover 202 with the carrier adjacent to the first cavity 203 and the opening 2031 that seals the first cavity 203 are discarded or processed together. The volume of the first cavity is generally larger than the volume of the second cavity. They can also be designed according to the difference in volume as described above. Of course, the volume of the first cavity can also be equal to the volume of the second cavity. Optionally, the volume of the first cavity can also be smaller than the volume of the second cavity.

In some embodiments, there is no particular limitation on the shape of the first cavity and the shape of the second cavity. For example, usually, the shape of the first cavity is cylindrical, and the shape of the second cavity is cylindrical. Of course, the shape of the first cavity can be a cuboid, a cube, an ellipsoid or a cone, and correspondingly, the shape of the second cavity can be a cuboid, a cube, an ellipsoid or a cone.

The above describes the detachable manner of the first cavity and the second cavity. Generally, the second cavity is located inside or at the bottom of the first cavity, or, at the beginning, the first cavity and the second cavity are combined together. Generally, after collecting the liquid, the first cavity and the second cavity are separated. Of course, the specific position of the second cavity is not limited, and the second cavity can also be in other ways.

Sealing elements

In some preferred embodiments, after the first cavity is separated from the second cavity or before separation or before phase separation, the first cavity and the second cavity, which were originally in a liquid flow state, are not in a liquid flow state, thereby preventing the liquid from flowing between the first cavity and the second cavity. Alternatively, the first cavity and the second cavity have the following states for whether the liquid is connected: the first state is that the liquid is not connected, and the second state is that the liquid is connected; or the first state is that the liquid is connected, and the second state is that the liquid is not connected. As for the different states of the second cavity and the second cavity in different purposes or operation processes, whether they are in liquid connection or not, they can be designed and selected arbitrarily. For example, when the first cavity collects a fluid sample or a liquid sample, the first cavity and the second cavity are in a liquid flow state; when it is necessary to separate or separate, the second cavity is not in a liquid flow state with the first cavity. Alternatively, when the first cavity collects a fluid sample or a liquid sample, the first cavity and the second cavity are not in a liquid flow state; when it is necessary to separate or separate, the second cavity is not in a liquid flow state with the first cavity, so that the second cavity collects the liquid from the first cavity, and then the first cavity and the second cavity are not in a liquid flow state, so that the second cavity is separated from the first cavity.

Therefore, in some embodiments, a sealing element is provided. If the first cavity 103 is detachably combined with the second cavity 104 through the connecting channel 109, the sealing element seals the connecting channel, and the liquid in the first cavity cannot enter the second cavity again, or the liquid in the first cavity cannot flow out through the channel for the liquid entering the second cavity. The so-called preventing the liquid from flowing out through the connecting channel is to seal the connecting channel or substantially seal the place where the first cavity and the second cavity are connected. This connection can be indirectly connected through the connecting channel, or it can be connected without connecting the connecting channel. In any case, in these embodiments, after the second cavity is separated from the first cavity, or at the same time, or before the separation, the place where the first cavity and the second cavity are connected is in a liquid-tight state, so that the liquid cannot enter the second cavity, or after the second cavity is separated, the liquid sample will not leak into the outside environment of the first cavity through the connection. In some preferred embodiments, the liquid cannot leak into the external environment of the first cavity containing the detection cavity through the connection, or the liquid cannot leak into the external environment of the first cavity containing the test element through the connection. It can be easily understood that when the connection and liquid circulation are not achieved through the preferred mode of the present invention, "connection channel", but through two independent structures, the connection structure and the circulation channel, once the first cavity and the second cavity are separated by the connection structure, the liquid flow can be achieved by sealing the circulation channel with a sealing element. Therefore, the function of the sealing element is to prevent the first cavity and the second cavity from being in a state of liquid circulation, and change from a state of liquid flow to a state of liquid non-flow.

In some preferred embodiments, when the second cavity is detachably connected to the first cavity through the connecting channel, before, after or while the second cavity is separated from the first cavity, the connecting channel is sealed by a sealing element. The sealing element can seal the first opening 1091 of the connecting channel, as shown in Figure 12. Here, the sealing element is like a plug, blocking the opening 1091 of the connecting channel, thereby preventing the liquid from entering the second cavity, or preventing the liquid from flowing out of the first opening 1091 of the connecting channel to the outside of the first cavity. The sealing element here can be matched or adapted to the shape of the opening of the connecting channel, thereby sealing the connecting channel. Adaptation here means that the sealing element and the connecting channel cooperate with each other through one or a combination of suitable size, suitable material, and suitable shape to play a role of liquid sealing. For example, the first opening of the connecting channel is circular, and the sealing element is also circular, or the connecting channel is plastic, and the sealing element is also plastic, relying on the mechanical elasticity of the material itself to seal, or the sealing element is rigid, and the connecting channel is elastic, or the sealing element is rigid, and the connecting channel is rigid, these methods can achieve the effect of sealing, thereby realizing the function described above. For example, the sealing element is elastically deformable, while the connecting channel is rigid, and the sealing element is inserted into the connecting channel, thereby sealing the opening of the connecting channel. This sealing method can be selected arbitrarily. The sealing element can be used alone to seal the connecting channel or to seal the place where the first cavity and the second cavity flow, so that the first cavity and the second cavity are in liquid communication.

In some preferred embodiments, the first cover 102 includes a sealing element for sealing the connecting channel, and the sealing element seals the opening of the connecting channel while the first cover covers the opening of the first cavity. In fact, the sealing element and the cover form a linkage mechanism, and the movement of the cover drives the movement of the sealing element. The movement of the first cover is to seal the opening of the first cavity. If the first cover moves, the sealing element can also seal the connecting channel at the same time, which is more convenient in operation. Of course, it can be understood that the first cover covers the first cavity and the sealing element seals the connecting channel is not linked, and it can be completed in two steps and also belongs to the scope of the present invention. Preferably, the sealing element seals the first opening of the connecting channel. It can also be said that the movement of the first cover and the change of the state of the first cavity and the second cavity being in liquid communication are completed together. For example, the movement of the first cover changes the first cavity and the second cavity in liquid communication to the state where the first cavity and the second cavity are not in liquid communication during the movement. Or, the movement of the first cover changes the state where the first cavity and the second cavity are not in liquid communication to the state where the first cavity and the second cavity are in liquid communication, and with the movement, the state where the first cavity and the second cavity are not in liquid communication is made.

The covering here may refer to the first cover body and the first cavity body cooperating to cover the opening 1031 of the first cavity. Of course, it may also be that the cover body seals the opening 1031 of the first cavity 103. The sealing here may be just a general sealing, or it may also be an unsealed state, which only prevents the liquid sample from spilling out of the first cavity, for example, when the first cavity is moved, the liquid is prevented from overflowing from the opening 1031 of the first cavity. As described above, the covering of the first cover body and the opening of the first cavity does not need the sealing effect of the traditional detection device, because the entire detection device does not need to be transported or transported under some extreme conditions. The sealing element is on the cover body. When the first cavity collects a sufficient amount of liquid, the cover body is generally required to cover the opening of the first cavity. When the cover body covers the opening 1031 of the first cavity, the sealing element connected to the cover body simultaneously seals the opening of the connecting channel or the connecting channel, so as to prevent the liquid from entering the second cavity. When the second cavity is separated from the first cavity, the liquid cannot leak to the outside through the connecting channel. This makes the operation more convenient, simple and quick, and completes two functions in one step. The sealing effect of the sealing element sealing the connecting channel here can only be to temporarily prevent the liquid from leaking to the outside through the connecting channel, and does not require the sealing effect of the traditional detection device to ensure that it cannot leak under extreme transportation conditions (such as high pressure or vacuum). This is also because the sample in the second cavity is used as a transportation carrier for secondary confirmation detection, while the liquid in the first cavity does not need to be transported or stored and can be discarded later. Therefore, the sealing of the opening 1031 of the first cavity and the connecting channel or the connecting channel opening 1091 here is only a general seal, and does not need to be sealed under negative pressure or vacuum like the traditional device. This is mainly because there is no need to connect the liquid in the first cavity to the first cavity and transport it to a professional laboratory or testing agency for secondary testing.

For the sake of convenience and low production cost, the first cavity and the second cavity are both made of plastic materials, which are all injection molded in one go, and the sealing element and the first cover body are also injection molded. Relying on the physical properties between the plastic materials, the sealing element can seal the connection between the first cavity and the second cavity, preferably, the connection channel connecting the first cavity and the second cavity is sealed. In order to achieve a better sealing effect, an elastic sealing ring 108, such as an "O" type sealing ring, such as a silicone sealing ring, can be set on the sealing element. The material of these sealing rings can be flexible relative to the material of the sealing element, so that when the sealing element seals the first opening 1091 of the connection channel, its sealing effect is increased. It can be understood that when the cover body and the sealing element are required to be linked, the opening of the first cavity of the first cover body is usually intertwined with a thread. The first is the opening of the first cavity of the cover body in a rotating manner, and the sealing element is also rotated to enter the connection channel or seal the opening of the connection channel, or seal the hole of the first cavity and the second cavity in liquid communication (if the connection channel is omitted).

It can be understood that the "O" type sealing ring is used in conjunction with the sealing element. The "O" type sealing ring can be produced separately and then assembled on the sealing element, so that it has the function of sealing. Of course, the structure of the "O" type sealing ring can be made of the same material as the location where the "O" type sealing ring is installed, but it is completed in one go through injection molding, which facilitates production and processing technology. Of course, in other cases, the "O" type sealing ring can also be omitted, and sealing can be achieved only by relying on the different materials of the connecting channel and the sealing element.

In some preferred embodiments, when the sealing element is connected to the first cover body, it can be formed by injection molding at one time, or it can be connected to the cover body in a detachable manner. For example, as shown in Figures 2 and 3, a sealing element 1028 is connected to the first cover body, a sealing ring 108 is arranged on the sealing element, and the sealing element is an integral structure with the cover body 102. In order to better fix the sealing ring, a groove structure is arranged on the sealing element so that the sealing element is elastically fixed on the groove. Generally, the first cavity needs to accommodate a certain volume of liquid sample, so it has a certain volume, so the opening 1031 of the first cavity has a distance from the first opening 1091 of the connecting channel at the bottom of the first cavity, so the sealing element is connected to the cover body 102 through the connecting structure 1023 to form an integral structure. As shown in FIG. 12 , when the cover body is closed onto the opening 1031 of the first cavity by closing, for example, rotating, the sealing element 1028 connected to the cover body is also rotated into the connecting channel 109. As the cover body is closed, the sealing element enters the connecting channel, so that the sealing element 1028 seals an opening 1091 of the connecting channel, thereby preventing the liquid sample from entering the first cavity. When the second cavity is separated from the first cavity, the liquid sample in the first cavity will not leak to the outside through the connecting channel.

For example, as shown in FIG22, the first cover 202 is connected with a connection structure 2023, and the connection structure 2023 extends a section to serve as a sealing element 2028 to seal the connection channel; in the state shown in FIG22, when the sealing element 2028 (that is, the area 208 with a sealing ring) is not close to the opening 2091, the first cavity and the second cavity are in a liquid flow state. As the position of the cover changes, the sealing element approaches the position of the opening 2091, and as it moves, the sealing element seals the opening 2091, and at this time, a sealing effect is achieved, and the liquid in the first cavity will not flow into the second cavity.

It is a preferred method to use the cover body and the sealing element in linkage, so that the first cavity and the second cavity are not in a liquid communication state. Of course, the cover body and the sealing element can be completed by injection molding at one time, or they can be assembled together by injection molding multiple times. For example, the cover body is completed by injection molding at one time, and the connecting rod 2023 and the sealing element 2028 are completed by injection molding at one time; then they are combined together by any optional plug-in, thread or other method, so that the movement of the cover body drives the sealing element to move together, which is called "linkage". In another way, it is also possible to inject the sealing element, the connecting rod and the cover body separately and then assemble them together.

Therefore, in some preferred embodiments, the sealing element is also connected to the cover body in a detachable manner. For example, as shown in Figures 31-35, the cover body 402 includes a sealing element 4028, the shape of which matches the shape of the connecting channel or matches the first opening 1091, 3091, such as the shape of a piston. In this way, a part of the connecting structure 4023 is used as a sealing element 4028, and at this time there is no sealing ring. However, the material can be different. Generally, the material of the sealing element is generally more elastic. In this way, even if there is no sealing ring, the elastic sealing element is easier to seal the connecting channel or the first opening of the connecting channel. For example, the sealing element can be latex, silicone, or other elastic materials, or the sealing element is composed of two parts, the inner part is composed of a relatively hard material, and a layer of elastic silicone, rubber, latex, etc. is covered on the surface of the hard material to enhance the sealing effect between the sealing element and the connecting channel or the opening 1091. At the same time, when the first cover body 402 covers the opening of the first cavity 103, 203, it takes less effort to allow the sealing element 4028 to seal the connection channel or opening, for example, the sealing element enters the connection channel to seal the connection channel. Alternatively, the sealing element 5029 (when the structure 5029 is used as the sealing element) is connected to the connecting rod 5023 through threads, such as Figures 33-34. In this embodiment, one end 5030 of the sealing element 5029 is provided with an external thread, and one end on the connecting structure 5023 is provided with an internal thread. The sealing element is connected to the cover body through the threaded form as an integral structure. In this way, the sealing element can have different materials from the cover body and the connecting structure, and the sealing element has more design forms and methods to meet different sealing needs.

The seal here may be a separate component or be arranged at the connection between the second chamber and the first chamber, which can block the flow of liquid between the second chamber and the first chamber. The flow here is generally active flow. In fact, when the liquid flows passively from the second chamber to the first chamber, the sealing element is not necessary.

In addition, as described above in conjunction with FIG. 27, when the first cavity and the second cavity are not provided with a connecting channel structure, there is actually only one hole, such as a hole similar to 3091, and the portion 3098 extending from the connecting channel is missing. In this case, the sealing element only needs to seal the opening 3091, and it is not necessary to allow the sealing element to enter the connecting channel. For example, the sealing element is a rubber plug, which is provided on the connecting rod 3023 of the cover body, and the linkage of the cover body drives the plug to plug the opening 3091, thereby realizing the change of the liquid flow state between the first cavity and the second cavity.

In addition, the sealing element can seal the first opening of the connecting channel at the beginning. After the first cavity 103 collects the liquid sample, or before or after the first cavity liquid sample is tested for the first time, the sealing element is pierced by the piercing element or the sealing element is cancelled, so that the liquid sample flows into the connecting channel and enters the second cavity 104 through the second opening. Moreover, the second cavity and the first cavity are a detachable combination, so that the second cavity is separated from the first cavity for subsequent possible confirmation tests. Therefore, when the sealing element is pierced, the sealing element here can be a pierceable structure, for example, such a sealing element can be a self-adhesive sticker, a double-sided adhesive, a plastic sheet, etc. Generally, the pierceable element will not allow the liquid to enter the connecting channel at the beginning, but only after being pierced. There are many ways to be pierced, for example, piercing with a sharp object. In some ways, the piercing element can be set on the first cover 102, and the cover is linked to the piercing structure. When the first cover covers the opening of the first cavity 103, the piercing element is the sealing element, so that the liquid flows from the first cavity to the second cavity. If the first cavity and the second cavity need to be separated, before separation, another sealing element is used to seal the puncture site, thereby achieving a change in the liquid flow state between the first cavity and the second cavity.

For example, as shown in the diagrams of FIGS. 39-40 , the first cavity 702 includes an opening 7031 for receiving a liquid sample, and a hole is provided in the first cavity, which is a first opening 7091 of a connecting channel, and the opening is sealed by a pierceable sealing element 7028, and the detection cavity 705 in liquid communication with the first cavity is in liquid communication through a channel 7038. The difference from that shown in FIGS. 37-38 is that the first cavity is used as a cavity for collecting liquid samples for initial detection, and the second cavity 704 is detachably connected at the second opening 7092 of the connecting channel. When a liquid sample is collected, the liquid portion of the first cavity flows into the detection cavity for initial testing, and then the opening of the first cavity is covered with a first cover body, the cover body is provided with a second cover body, and the first cover body is provided with a sealing element 7028 and a piercing element 7029. In this way, the cover body, the sealing element 7028 and the piercing element 7029 form a linkage mechanism. When the first cover body covers the first cavity, the sealing element and the piercing element are driven to be linked. The piercing element pierces the seal of the first opening of the sealing connection channel, and then releases the liquid into the second cavity, and then seals the opening of the second cavity with the seal. Of course, the piercing element can also have the function of removing part of the liquid in the second cavity. At this time, the piercing element can also have a hydrophobic channel, a liquid inlet and a receiving cavity. In this way, after piercing the first opening 7091 of the sealing connection channel, the piercing element is directly partially inserted into the second cavity. In order to allow the liquid to be removed, the liquid can be allowed to flow into the receiving cavity through the liquid inlet of the hydrophobic channel. For example, the receiving cavity is located in the piercing element. This can be clearly understood and combined with the detailed description below. For example, as shown in the figure above Figure 40. When a secondary confirmation test is required, the second cavity is removed from the first cavity, such as by rotating the thread to remove it, and then the opening 7041 of the second cavity 704 is sealed with the second cover body to perform a subsequent secondary confirmation test.

In summary, allowing the liquid to flow from the first cavity to the second cavity can mean that when the liquid enters the first cavity, it can also flow to the second cavity, or after the liquid sample flows into the second cavity, the liquid does not enter the second cavity at the same time or immediately. This is because the second cavity is not in liquid communication with the first cavity, but at any time thereafter, the second cavity is in liquid communication with the first cavity. The way of not being in liquid communication and being in liquid communication is a matter of controlling the timing of the sealing element. For example, puncturing the sealing element on the first opening 1091 or the second opening 1092 of the sealing connection channel is a way to connect the two cavities. Of course, in order to separate the second cavity and prevent the liquid in the first cavity from continuing to flow into the second cavity, sealing is also required after puncturing.

Therefore, in some methods, when the first cavity 104 is not used to collect liquid samples, the second cavity is in liquid communication with the first cavity, and when collecting liquid or after collecting liquid samples, the second cavity is not in liquid communication with the first cavity. Of course, optionally, when the first cavity 104 is not used to collect liquid samples, the second cavity is not in liquid communication with the first cavity, and when collecting liquid or after collecting liquid samples, the second cavity is in liquid communication with the first cavity, and when or after the liquid sample enters the second cavity, before the first cavity and the second cavity need to be separated, the second cavity and the first cavity are again not in liquid communication. In the above methods, the sealing element plays different functions at different times. When to seal and when not to seal can be selected according to the appropriate timing.

In the above examples where a sealing element is required, the liquid sample can always flow freely from the first cavity 103 to the second cavity (for example, under the action of gravity, the liquid always flows from a high position to a low position), and the sealing element is used to avoid continued flow after the two cavities are separated; however, in fact, when the liquid sample passively overcomes gravity and flows from a low position to a high position, a sealing element is not necessarily required. For example, in the example of Design 3, a separate sealing element is not required.

Liquid-repellent channel

The "liquid-repellent channel" mentioned here is a channel similar to a liquid discharge channel, through which the liquid is dredged or discharged, and can also be considered as a channel that allows liquid to flow from one place to another through the channel. In addition, the "liquid-repellent channel" here can also remove excess gas, thereby relieving the effect of pressure; through this channel, the gas is dredged or discharged, and can also be considered as a channel that allows gas to flow from one place to another through the channel. Therefore, the "liquid-repellent channel" here can remove excess liquid, or excess gas, or a mixture of gas and liquid. The so-called "channel" usually means, for example, the shape of a tube, such as being closed on all sides, and including two openings, one opening can be used as a liquid inlet, and the other opening can be used as a liquid outlet; or, one opening can be used as an air inlet, and the other opening can be used as an air outlet; or, one opening can be used as a port for the mixture of liquid and gas, and the other opening can be used as a port for the mixture of liquid and gas. The one inlet and one outlet here are just one embodiment, and of course it can contain one or more inlets, and can also include one or more outlets. The length of the channel itself here is

There is no limitation, it can be longer or shorter, which can be easily realized by a person skilled in the art according to the actual situation.

In some more preferred ways, if only the hole between the first cavity and the second cavity is sealed, sealing can be achieved. However, if a better sealing effect is desired, for example, when a connecting channel is used to connect the first cavity and the second cavity, the connecting channel generally has an extension section 3094, which extends to the opening of the second cavity in FIG. 27. Of course, it can also extend a distance or length into the first cavity at the connecting channel 3091. In order to achieve a better sealing effect, a plug-like sealing element generally needs to be partially inserted into the connecting channel to seal the connecting channel. Generally, before sealing the connecting channel, the connecting channel contains a liquid sample, and the second cavity is also filled with a liquid sample. This is because the collected liquid sample needs to meet the secondary confirmation test and the initial test for the test element, and the liquid sample still needs a sufficient volume. Therefore, in some preferred ways, the liquid level of the liquid sample in the first cavity is higher than the position of the first opening of the connecting channel, that is, the first opening of the connecting channel is located below the liquid level, so that the connecting channel and the second cavity are filled with liquid. In such a case, the sealing element should be partially inserted into the connecting channel to achieve a better sealing effect. This liquid seal prevents the liquid sample from leaking from the first cavity to the outside after the second cavity is separated from the first cavity. In such a case, it is difficult for the sealing element to enter the connecting channel, because although the sealing element is of the same size as the connecting channel, it is necessary to overcome a certain reaction force of the liquid acting on the sealing element when sealing the connecting channel 109. This is because, in order to achieve a better sealing effect, the sealing element needs to be inserted into a part of the connecting channel to obtain a better seal. In order to obtain a better seal, in the presence of a connecting channel, the sealing process is a dynamic process, from the sealing element approaching the first opening of the connecting channel (first state), to the sealing element completely blocking the first opening of the connecting channel (second state, this is acceptable and can play a sealing role), and then to the sealing element entering the connecting channel (third state, reaching the third state is to obtain a better sealing effect). During this process, when it is necessary to change from the second state to the third state, it is actually necessary to overcome the reaction force of the liquid sample in contact with the sealing element in the connecting channel. In particular, the sealing element enters the connecting channel and needs to press the liquid in the connecting channel. If the liquid cannot be removed, it is difficult to change the sealing element from the second state to the third state. The distance from the first opening of the sealed connecting channel to the distance of entering the connecting channel can be 0.1-10 mm, or a longer distance, so as to ensure a better sealing effect, for example, the distance of the sealing element entering the connecting channel is 0.1 mm, 0.2 mm, 0.3 mm, 0.4 mm, 0.5 mm, 0.6 mm, 0.7 mm, 0.8 mm, 0.9 mm, 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm or 7-10 mm. In order to reduce the reaction force of the liquid, which is the pressure applied by the liquid to the sealing element, the liquid volume discharged by the sealing element needs to be discharged smoothly to another place, so as to reduce the reaction pressure borne by the sealing element, so that the sealing element can enter the connecting channel more easily. Therefore, it is necessary to discharge part of the liquid volume in the connecting channel when the sealing element enters the connecting channel, so that the sealing element can enter the connecting channel smoothly, thereby smoothly sealing the connecting channel or the opening of the connecting channel. This is similar to the principle of plugging the bottle stopper into the bottle opening. If the bottle is full of water, it is difficult to plug the stopper in. You need to pour out some of the water or liquid in the bottle so that the stopper can be plugged into the bottle mouth to seal the bottle opening. However, when the second chamber is full of liquid and the connecting channel is also full of liquid, sometimes the first opening of the connecting channel is below the liquid level of the first chamber, and a sealing element needs to enter or the sealing element needs to seal the opening of the connecting channel in the form of a piston. This requires that some of the liquid in the connecting channel be removed to another place to facilitate the sealing element to enter the connecting channel. The best way is to remove some of the liquid when entering. The sealing element enters the connecting channel when it is forced by external force.

Therefore, in some preferred embodiments, the device further includes a hydrophobic channel, through which the squeezed liquid generated by the connecting channel into which the sealing element enters can be discharged outside the connecting channel, thereby allowing the sealing element to smoothly enter the connecting channel. For example, in some preferred embodiments, the liquid inlet of the hydrophobic channel is located on the sealing element, and as the sealing element enters the connecting channel, excess liquid enters the hydrophobic channel through the liquid inlet, thereby being discharged outside the connecting channel. The outside of the hydrophobic channel mentioned here generally refers to a place other than the connecting channel and the second cavity detachably connected to the connecting channel, such as a receiving cavity, such as the first cavity, or the detection cavity, or other places. Therefore, the present device further includes a receiving cavity, which is used to receive liquid or gas from the hydrophobic channel. Generally, the sealing element seals the connecting channel or blocks the first cavity from flowing or flowing liquid with the second cavity, which is generally divided into two states. First, before the sealing element seals the connecting channel, the first cavity and the second cavity are connected. At this time, the liquid can be exchanged in the two cavities, and generally the liquid can flow naturally from the first cavity to the second cavity. Second, when the sealing element begins to seal the connecting channel, such as the opening of the connecting channel, the first cavity and the second cavity are not connected. As the sealing element continues to enter the connecting channel, the pressure of the connecting channel and the second cavity will increase. Due to the effect of pressure, the liquid in the connecting channel and the second cavity will enter the receiving cavity through the liquid inlet of the hydrophobic channel to reduce the pressure of the former, so that the sealing element can smoothly seal the connecting channel. Of course, the hydrophobic channel here can be set arbitrarily, and generally the hydrophobic channel and the receiving cavity are in liquid communication. In this way, if the sealing element continues to enter the connecting channel, the discharged liquid enters the receiving cavity through the hydrophobic channel.

In some embodiments, such as shown in Figures 3 and 2, the sealing element 1028 is used to seal the opening 1091 of the connecting channel 109, and the receiving chamber can be located in the sealing element, for example, the sealing element is a hollow structure, so that the liquid discharged can enter the receiving chamber, and the hollow structure 1029 can be used as a receiving chamber. For example, as shown in Figure 3, the sealing element 1028 also includes a receiving chamber 1029. When the sealing element enters the connecting channel, the excess liquid enters the receiving chamber 1029 through the hydrophobic channel 1025, thereby reducing the pressure. Of course, the hydrophobic channel 1025 here is very short, because the sealing element is a thin-walled structure or the sealing element is a hollow structure. Of course, it is easy to understand that the receiving chamber is not necessarily located on the sealing element. When the connecting rod structure 1023 is a hollow structure 1030, the hollow structure 1030 and the receiving chamber 1029 are connected to form a large receiving chamber to accommodate the liquid volume discharged by the sealing element, or the hollow structure 1030 is used as a receiving chamber, which has an equivalent effect. In some preferred embodiments, for example, as shown in Figs. 2-3 and 12, the sealing element 1028 seals the opening of the connecting channel 1091 and enters the connecting channel 109, while the excess liquid enters the receiving chamber 1029 through the hydrophobic channel 1025. In such an embodiment, the opening at one end of the hydrophobic channel (liquid inlet) is in communication with the liquid in the connecting channel, while the liquid at the other end of the opening (liquid outlet) is in communication with the liquid in the receiving chamber, so that the liquid can enter the receiving chamber. Here, since the hydrophobic channel is provided on the hollow sealing element, the hydrophobic channel is very short. No matter how short it is, there is always a liquid inlet and a liquid outlet. In fact, when the receiving chamber is located in the sealing element or the subsequent liquid discharge element, there is no strict division between the liquid inlet and the liquid outlet. Only when the liquid drainage channel is relatively long, there is a division between the positions of the liquid inlet and the liquid outlet. This is because the sealing element or the liquid discharge element is a hollow structure, and the wall is also very thin. In fact, a hole is opened in the wall, and the hole plays the role of allowing the liquid to enter the receiving chamber. At this time, there is no necessary position division for the liquid inlet or the liquid outlet. The hole can also be called a liquid inlet or a liquid outlet. In short, the position division is not very obvious.

In some preferred embodiments, as shown in FIG12 , the liquid inlet of the lyophobic channel is located below the sealing element. In some preferred embodiments, the liquid inlet of the lyophobic channel is located on the sealing element and enters the connecting channel earlier than the sealing element, so that the excess liquid can be discharged out of the connecting channel, thereby reducing the reaction resistance of the liquid surface borne by the sealing element. The lyophobic channel here can refer to the through hole on the receiving cavity 1029. Such lyophobic channels can be one or more.

In a preferred embodiment, the liquid inlet of the hydrophobic channel enters the connecting channel before the sealing element. Therefore, in some ways, if the hydrophobic channel is relatively long and the first cavity is used as a receiving cavity, the liquid inlet of the hydrophobic channel is located on the sealing element, but enters the connecting channel earlier than the sealing element, so that as the sealing element enters the connecting channel, the discharged liquid enters the hydrophobic channel through the liquid inlet of the hydrophobic channel, and then enters the first cavity through the liquid outlet of the hydrophobic channel, or enters the receiving cavity. Here, the first cavity is a specific way of the receiving cavity, and the first cavity can also be a cavity with the common function of the receiving cavity. Therefore, the receiving cavity is not necessarily located on the sealing element, and the best way is to be located on the sealing element or in the connecting rod that connects the sealing element to the cover body. In this way, as the sealing element enters the connecting channel, the excess liquid is discharged from the connecting channel through the liquid inlet of the hydrophobic channel. This exclusion is the liquid that is forced to be discharged due to the pressure on the liquid surface generated by the sealing element entering the connecting channel. Of course, the size of the receiving cavity is related to the discharged liquid. Just set a suitable volume capacity to accommodate the discharged liquid.

The positional relationship of the "liquid inlet of the lyophobic channel" is that if the sealing element needs to enter the connecting channel, it will compress the liquid sample in the connecting channel. In this case, the position of the liquid inlet should be below the sealing element. The so-called "below" is only a relative position and is not necessarily located on the sealing element. For example, it can be located on the wall of the connecting channel. When the sealing element enters the connecting channel, the liquid inlet on the wall of the connecting channel is relatively located below the sealing element. As the sealing element continues to enter the connecting channel, part of the liquid is forced to enter the liquid inlet and be excluded, thereby allowing the sealing element to enter smoothly. In one case, the sealing element can continue to enter the connecting channel until the sealing element and the liquid inlet on the wall of the connecting channel overlap, and the liquid cannot enter the lyophobic channel through the liquid inlet, and is thus excluded from the connecting channel. Therefore, in some preferred embodiments, the liquid inlet is located below the sealing element. For example, as shown in Figures 2-3, a liquid inlet 1032 is set below the position of the sealing element 1028, and the liquid inlet of the lyophobic channel 1025 is the liquid inlet.

For another example, as shown in Figures 15, 18, 22, 23, and 27. For example, as shown in Figures 15-24, the sealing element 2024 and the connecting structure 2023 are an integrated structure, the extended portion of the connecting structure serves as a sealing element, and the entire connecting structure and the extended structure are hollow structures 2030, 2029, the hollow structure is used as a large receiving cavity, and the liquid inlet 2025 of the hydrophobic channel is an opening located on the side wall of the extended structure, the opening is the liquid inlet of the hydrophobic channel, and is also located under the sealing element. For another example, as shown in Figure 23, when the sealing element 2028 enters the connecting channel, the inlet 2025 of the hydrophobic channel located under the sealing element discharges excess liquid to the outside, thereby reducing the resistance of the sealing element to enter. In some preferred embodiments, the difference from the structure shown in FIG. 31 is that the sealing element 3028 lacks the sealing ring 208, and it is a part of the connection structure 3024 as a sealing element. At the same time, there is an opening 3025 at the top of the extension structure of the connection structure, and the opening 3025 is connected to the hollow receiving chamber 2039 located in the sealing element. When the sealing element enters the connection channel, the excess liquid sample enters the receiving chamber through the liquid-repellent channel inlet 3025. For example, as shown in FIG. 33-35B, although the sealing element 4029 and the connecting rod 4024 are detachably combined, the liquid inlet 4038 is set at the top of the sealing element to remove the excess liquid. It can be understood that in order to better seal the connection channel, the shape or size of the sealing element is preferably matched with the connection channel. For example, if the connection channel is a circular hollow structure, the sealing element is also a circular structure to facilitate the sealing cooperation between the two.

Continuing to refer to Figures 33-35, a connecting rod 5023 is provided on the first cover body 502, and a sealing element 5028 is provided on the connecting rod. The sealing element can be used to seal the connecting channel. If the sealing element 4028 described above is used to seal the connecting channel, a liquid inlet 4038 of the liquid-repellent channel is provided at the top 4029 thereof, and the sealing element 5028 includes a receiving chamber 5030 to collect the liquid discharged by the sealing element entering the connecting channel. Of course, a liquid inlet 5025 can also be provided below the sealing element 5028. When the sealing element 5028 enters the connecting channel to seal the connecting channel, the excess liquid enters the receiving chamber through the liquid inlet 5025, that is, the hollow structure serves as the receiving chamber 5030. At this time, the component 4029 does not play a sealing role, but a liquid discharge role, and the sealing role is at the extended end 4028 of the connecting rod 4024.

Of course, if the partial structure 5028 of the connecting rod 5022 is not used as a sealing element, but a sealing element 5029 is set on the structure shown in 5035, as shown in Figures 33-35, the sealing element 5029 can be detachably connected to the connecting rod, such as plug-in, threaded or snap-on. For example, the element 5035 includes an end 5030 with an external thread, which cooperates with the internal thread 5027 of the connecting rod. The sealing element 5029 cooperates with the inner wall of the connecting channel to seal the connecting channel. The liquid inlet of the liquid-repellent channel is set at the top 5038 of the element 5035. When the sealing element 5029 enters the connecting channel, the excess liquid head enters the receiving cavity 4029 in the sealing element through the liquid inlet 4038. At this time, the liquid inlet 5025 can be missing or omitted.

In some preferred embodiments, in order to facilitate the removal of liquid and to facilitate and effectively allow the liquid to enter the liquid inlet, the vertical plane position of the liquid inlet of the hydrophobic channel is lower than the vertical position of the outermost surface of the sealing element. In other words, the horizontal projection area of the position of the liquid inlet of the hydrophobic channel is not completely consistent with the horizontal projection area of the sealing element. Preferably, the horizontal projection area of the position of the liquid inlet of the hydrophobic channel is located within the horizontal projection area of the sealing element. From another meaning, the sealing element needs to contact the inner wall of the connecting channel, and the position of the liquid inlet of the hydrophobic channel is preferably not in contact with the inner wall of the connecting channel, because the contact will seal the liquid inlet; this facilitates the liquid to enter the liquid inlet of the hydrophobic channel and be removed. For example, as can be seen from Figures 2 and 3, the diameter of the position of the sealing element with the sealing ring 108 is greater than the diameter of the position of the liquid inlet 1025, so as to avoid the position of the liquid inlet 1025 from contacting the inner wall of the connecting channel and affecting the liquid from smoothly entering the hydrophobic channel and reaching the receiving cavity. In FIG. 2 , the dotted area 1055 is the area A-A’ of the projection of the sealing element, and the projection area point or area of the liquid inlet 1025 is at B, and the projection area is located between A-A’. Therefore, according to this principle, in some schemes, the sealing element can have an inverted cone structure (the function of the structure will be explained later, that is, it has the function of draining liquid), and the liquid inlet 1025 of the lyophobic channel is located on the surface of the cone, so that the liquid inlet of the lyophobic channel will not contact the inner surface of the connecting channel, and the liquid to be discharged can enter the liquid inlet of the lyophobic channel and be discharged. It can also be understood from FIG. 18 that the position of the sealing element 2028 is due to the presence of the sealing ring 208, so the projection of the liquid inlet 2025 located at the sealing element 2028 is located within the projection of the sealing ring. It can also be easily understood similar to FIG. 27 that with an inverted cone shape, the liquid inlet of the lyophobic channel is set on the surface of the cone, which makes it easy for liquid to enter the lyophobic channel, thereby discharging excess liquid sample. For example, in Figures 31-32, the liquid inlet of the hydrophobic channel is set at the top position, and the situation that the side wall of the connecting channel seals the liquid inlet of the hydrophobic channel will not be considered, but the principle that the projection of the liquid inlet position is located in the horizontal projection area of the sealing element is still satisfied. Looking at Figures 33-34 again, whether the extended end 5028 of the connecting rod 5023 is used as the sealing element, or the part shown in 5029 is used as the sealing element, the projection of the liquid inlet 5025 or 5027 of the hydrophobic channel is still located within the horizontal projection of the sealing element. This is because the liquid inlet 5025 or 5027 is set in the recess, and the liquid inlet will not be sealed or blocked by the side wall of the connecting channel. Generally, the inner wall of the connecting channel is flat and smooth, so it is easy to be sealed. Such a structure is convenient for the removal of liquid.

In short, when the sealing element seals the connecting channel, the preferred way is to let the sealing element enter the connecting channel. In order to reduce the pressure of the sealing element entering, a liquid-repelling channel needs to be set to discharge the liquid discharged by the sealing element entering the connecting channel to another place. As described in the specific method above, the liquid inlet of the liquid-repelling channel is set under the sealing element, and one end of the liquid-repelling channel enters the connecting channel earlier than the sealing element, so that excess liquid can enter the liquid-repelling channel. As described above, when the receiving chamber is inside the sealing element or located at other positions, the other outlet (liquid outlet) of the liquid-repelling channel is connected to the receiving chamber, thereby accommodating excess liquid in the connecting channel.

In some other optional schemes, the first cavity can also be used as a receiving cavity, so that the liquid sample discharged by the sealing element in the connecting channel can be discharged into the first cavity through the lyophobic channel. In the above embodiments, the entrance of the lyophobic channel is located on the sealing element or on the connecting structure that is integrated with the cover body or under the sealing element. Of course, optionally, the lyophobic channel is not located on the sealing element, but can be located on the connecting channel. For example, the lyophobic channel is located on the side wall of the connecting channel, the entrance (liquid inlet) of the lyophobic channel is located on the side wall of the connecting channel, and the liquid outlet is connected to the first cavity. When the sealing element enters the connecting channel, the excess liquid discharged due to the entry of the sealing element enters the first cavity through the liquid inlet of the lyophobic channel until the sealing element seals the entrance of the lyophobic channel. A person skilled in the art who reads the embodiments of the present invention can imagine that no matter how the lyophobic channel is arranged, such as the positions of the liquid inlet and the liquid outlet, as long as it is able to exclude the liquid sample that is excluded because the sealing element enters the connecting channel, thereby reducing the resistance of the liquid of the sealing element to the sealing element, it will be sufficient. For example, the liquid inlet of the lyophobic channel can be located above the sealing element or at other positions.

In some other embodiments, the size of the liquid inlet can be arbitrarily designed, for example, liquid can enter, but the liquid cannot flow out freely from the liquid inlet. Because the liquid enters the lyophobic channel through the liquid inlet often due to the pressure of the liquid, when the liquid enters the lyophobic channel, the liquid will not flow out from the liquid inlet due to the surface tension of the liquid inlet. The advantage of this is that, because the liquid inlet is generally located below the sealing element, when the second cavity and the connecting channel are separated, the liquid inlet is exposed to the outside. If the liquid in the receiving cavity can flow out through the liquid inlet, it will also cause the risk of liquid sample contaminating the environment. Therefore, it is hoped that the liquid inlet can only allow liquid to enter but not flow out. Generally, the size of the liquid inlet is set, for example, 0.1-1-2 mm, and the liquid in the receiving cavity will not flow out from the liquid inlet due to surface tension.

In some embodiments, after the sealing element seals the connection channel, it can be separated from the first cover body if the sealing element is set on the cover body. In one embodiment, the sealing element is connected to the cover body as a whole or combined, and the sealing element seals the connection channel as the first cover body covers the opening of the first cavity. When the sealing is completed, if it is necessary to open the first cover body, so as to reversely rotate the first cover body to expose the opening of the first cavity, at this time, let the sealing element still stay in the connection channel to seal the connection channel, and remove the first cover body to remove part of the liquid sample from the first cavity for other detection or testing. For example, as shown in Figures 33-35, the sealing element 5029 and the cover body are detachably combined together through the connecting rod 5023, and at this time, the sealing element 5029 is located on the element 5035. The element 5035 is detachably combined with the connecting rod 5023 of the cover body, and this detachable method is not a threaded structure as shown in Figures 33-35, but a plug-in method, that is, one end 5030 of the element 5035 is inserted into one end of the connecting rod. After the first cover 502 drives the sealing element 5029 to seal the connecting channel, the second cavity can be separated from the first cavity, thereby sealing the opening of the second cavity, for example, the second cover is used to seal the opening of the second cavity, and the sample in the second cavity is used for the second test. At this time, the first cover 502 has covered the first cavity, for example, the opening 1031 of the first cavity 103 shown in FIG9; if it is necessary to take out the liquid sample from the first cavity at this time, the first cover is reversed at this time. When reversed, the sealing element and the connecting channel have a relatively tight fit, and the element 5035 is only plugged with the connecting rod. The first cover can be separated from the first cavity 103 again, and the element 5035 stays in the connecting channel. The advantage of this design is that if the first cavity is only used to collect samples, after the samples are collected, the connecting channel is sealed, and the liquid samples are separated, the first cover can be opened at this time, and part of the sample can be taken out from the first cavity for testing. If the test results need to be further confirmed and tested, the second cavity can be removed from the first cavity for a second test. In fact, samples can be taken out from the first cavity multiple times for multiple tests or assays with different indicators.

The liquid that needs to be removed is generally when the connecting channel and the second cavity are filled with liquid samples. It can be understood that when the liquid sample in the second cavity does not fill the second cavity, the connecting channel generally does not contain liquid samples. If the sealing element enters the connecting channel to seal the connecting channel, the liquid-repelling channel can remove part of the compressed gas to the outside of the second cavity, and can also reduce the resistance of the sealing element entering the connecting channel. The resistance at this time is due to the reaction force generated by the gas compression that hinders the sealing element from entering.

Therefore, in some preferred modes, in these two cases, when the connecting channel has liquid, the role of the hydrophobic channel is to exclude the liquid; when the second cavity is not filled with liquid, in order to better allow the sealing element to seal the connecting channel, the role of the hydrophobic channel at this time is to exhaust. Therefore, the hydrophobic channel plays two roles or any one of them at the same time in terms of function, so the hydrophobic channel can also be called a channel for discharging fluid, where the fluid refers to liquid or gas, or a mixture of the two, and correspondingly, the liquid inlet of the hydrophobic channel can also be called an air inlet, and the liquid outlet can also be called an air outlet, or collectively referred to as an inlet for fluid inlet and an outlet for fluid outlet. It can be understood that if it is necessary to exclude the compressed gas, there is no need to set up a special exhaust channel, and the hydrophobic channel can be used to achieve exhaust, and there is no need to specially design such a channel, because when the sealing element has liquid, it only needs to reach the level of liquid sealing, and if there is gas, it actually only needs to reach liquid sealing. Therefore, when it is necessary to exhaust the gas, the function of exhausting the gas can be selected in the small gap between the sealing element and the connecting channel element. These small gaps can be the errors between the mechanical structures, or they can be deliberately designed structures. These small gaps can allow gas to pass through but not liquid, thus achieving the effect of exhausting the gas. Of course, the exhaust channel or the exhaust structure here is not necessary, because the sealing element seals the connecting channel with a liquid sealing effect, not an air sealing effect. Relatively speaking, when a liquid seal is achieved, an air seal may not be achieved, but when an air seal is achieved, the liquid seal effect is also achieved.

The "liquid-repellent channel" is also a preferred mode of the present invention, because the sealing element can better seal the connecting channel, and a part of the sealing element can enter the connecting channel to achieve a better sealing effect. If it is another mode, the sealing element only seals the first opening of the connecting channel, and it is not necessary to seal the opening but to enter the distance of one end of the connecting channel, which is also feasible. In this case, the liquid-repellent channel can be omitted. If there is something else in the second cavity that is not filled with liquid, the liquid-repellent channel can also be omitted, because the role of the sealing opening or the connecting channel is not important, because there will be no liquid leakage.

Furthermore, in another case, it is not necessary to provide a structure similar to a liquid-repellent channel, for example, as shown in FIG. 31 (Design 2, when the opening of the connecting channel is sealed with a cover, a liquid-repellent channel is not required).

Drain components

In some preferred embodiments, the device of the present invention may further include a drainage element for discharging part of the liquid sample in the second chamber. The so-called "discharge element" here means that when an object enters the liquid sample, since the object has a certain volume, the volume will occupy a certain space in the liquid, thereby discharging a certain volume of liquid. The volume of the object entering the liquid is the volume of the liquid displaced, and the object entering the liquid can be called a drainage element. This can be understood as being similar to a ship in the water. Due to the weight of the ship, a certain volume of water needs to be displaced, and the ship will occupy the space originally occupied by the water. Of course, as mentioned above, if the space does not contain liquid but contains gas, after the drainage element enters the space containing gas, what is discharged is gas instead of liquid.

In some other ways, for example, when the second cavity is filled with liquid samples, even if the sealing element seals the connecting channel, the liquid in the second cavity is completely and substantially filled with the liquid sample. When the second cavity needs to be disassembled from the first cavity, since it is all mechanical operation, the liquid in the filled second cavity will overflow due to the mechanical operation, causing unfriendly operation and pollution to the outside world or the operator. In addition, even if the second cavity filled with liquid samples is carefully removed or disassembled from the first cavity, it is not easy to seal the opening of the second cavity with the second cover body, so that the second cavity filled with liquid can also cause some leakage risks during transportation. Therefore, in some more preferred ways, it is necessary to exclude part of the liquid sample in the second cavity from the second cavity while or after or before the sealing element seals the connecting channel. So that the liquid in the second cavity is not filled, so that the liquid sample in the second cavity separated from the first cavity will not overflow, which increases the safety and friendliness of the operation, and also reduces the risk of leakage during the subsequent secondary detection and transportation, and also increases the friendliness and safety of the subsequent second detection operation.

When the second chamber is removed from the device, as shown in FIG. 13 , a certain amount of space is reserved in the second chamber, so that the liquid does not fill up the second chamber. Thus, during removal, the liquid sample will not overflow from the second chamber, thereby reducing the risk of contaminating the outside world.

In some preferred embodiments, the device further includes a drainage element for discharging the liquid sample in the second cavity to the outside of the second cavity. It is understood that the drainage element can be any structure or method for reducing the liquid sample in the second cavity. In some preferred embodiments, the drainage element is formed as an extension of the sealing element, or the drainage element is located on the sealing element. For example, in Figures 2-3, the structures shown in Figures 18, 23, 27, 31, and 33. For example, in Figures 2-3, the sealing element 1028 and the drainage element 1027 are an integral structure, and the shapes of the drainage structure 1017 and the sealing element 1028 are roughly the same, except that the longitudinal dimension is slightly larger than the sealing element and the lateral dimension is smaller than the dimension of the sealing element. At this time, it can also be that the horizontal projection of the drainage element is located within the horizontal projection of the sealing element or that the horizontal projection of part of the drainage element is located within the horizontal projection of the sealing element. At this time, when the sealing element enters the connecting channel, the drainage element 1027 enters the connecting channel first. Since the diameter of the drainage element 1027 is smaller than the diameter of the connecting channel 109, all the excess liquid sample is discharged to the outside of the second cavity 104 or the first cavity 103 outside the connecting channel 109 through the space or gap 809 between the surface of the drainage element and the surface of the connecting channel 109. As the drainage element 1027 further enters the second cavity (as shown in FIG. 22, 12), at this time, the sealing element begins to seal the opening 1091 of the connecting channel 109, thereby sealing the liquid-tight connecting channel according to the above description. Since the drainage element 1027 enters the second cavity, part of the liquid sample in the second cavity is discharged. When the sealing element 1028 starts to seal the opening 1091 of the connecting channel, the liquid sample below the opening 1091 of the connecting channel cannot be discharged through the space between the surface of the discharge element 1027 and the surface of the connecting channel 109. If the sealing element needs to move downward, the liquid sample that continues to be discharged by the discharge element and the liquid sample discharged by the sealing element itself enter the lyophobic channel through the entrance of the lyophobic channel, and then enter the receiving chamber. Therefore, in some preferred embodiments, the entrance of the lyophobic channel is located on the discharge element. More preferably, the receiving chamber is located in the discharge element. It can be easily understood that the sealing element and the discharge element can be injection molded at one time. During injection molding, a hollow structure is injected to form a receiving chamber to accommodate the discharged liquid.

As mentioned above, in order to smoothly allow the liquid to enter the entrance of the hydrophobic channel and be discharged to the outside, the transverse diameter of the drainage element is smaller than the inner diameter of the connecting channel. For example, the drainage element can be in the shape of an inverted cone, and the drainage element of Figure 18, that is, the conical structure where the entrance 3025 of the hydrophobic channel is located. For example, the drainage element 3027 in Figure 27 is an inverted cone structure. The conical structure 4027 under the sealing element 4029 shown in Figures 31 and 32, and the conical structure formed by the drainage structure 435 shown in Figures 33-35. In fact, the drainage structure does not need a separate structure. If the sealing element is long enough, the sealing element can penetrate into the second cavity. At this time, the sealing element can play a dual role, that is, it realizes the change of the liquid flow state between the second cavity and the first cavity, and also excludes part of the liquid in the second cavity. Therefore, the drainage element is only a functional limitation, and does not require another structure to achieve it alone. In fact, these conical structures can also be used as drainage elements, which will be described in detail later.

In other embodiments, such as shown in FIGS. 15, 18, 22-23, and 27, the drain element 2027, 3027 and the sealing element 2028, 3028 are connected and are also formed by the extension of the sealing element. The sealing ring 208 is arranged outside the sealing element 2024, so that the sealing ring 208 is arranged on the surface of the sealing element and is slightly higher than the outer surface of the sealing element 2014. In this way, even if the diameter of the drain element 2017 is the same as the diameter of the sealing element 2024, when the drain element 2027 enters the connecting channel 209 (for example, as shown in FIG. 22), at this time, the sealing element and the drain element enter the connecting channel together. Since the drain element is located at the end and the sealing element is located above the drain element, the drain element enters the connecting channel first. If there is liquid in the connecting channel, the liquid discharged by the drain element entering the connecting channel enters the first cavity 103 through the gap 809 between the surface of the drain element and the inner surface of the connecting channel. With the further movement of the sealing element and the liquid discharge element, the liquid discharge element 2027 enters the first cavity, and at this time, the sealing ring may not have sealed the opening 2091 of the connecting channel 209. With the further entry of the liquid discharge element 2027 into the second cavity 204, the liquid can still be discharged into the first cavity 203 through the gap 809. When the sealing ring 2023 on the sealing element 2024 seals the opening 2091 of the connecting channel 209, the liquid cannot be discharged into the first cavity through the gap 900. At this time, the sealing element and the sealing ring need to continue to move in the connecting channel to achieve a stable sealing effect. Continuing to move requires continuing to discharge the liquid sample, and at this time, the redundant liquid sample removed by the liquid discharge is discharged into the connecting channel and the second cavity through the liquid inlet 2025 of the liquid-repelling channel. For example, enter the liquid-repelling channel through the inlet 2025 of the liquid-repelling channel, and then enter the receiving cavity 2029 or the first cavity through the liquid outlet of the liquid-repelling channel. At this time, the second cavity 204 is separated from the device, such as shown in Figures 24 and 28, and separated from the connecting channel. Since the liquid discharge element 2027 is located in the second cavity, part of the liquid sample in the second cavity is discharged. When the second cavity is disassembled from the device, such as shown in Figure 28, a certain space is reserved in the second cavity, and the liquid does not fill the second cavity. In this way, when disassembling, the liquid sample will not overflow from the second cavity, reducing the risk of contaminating the outside world.

It can be understood that the drainage element has the same size as the sealing element. Before the sealing element seals the connecting channel, the liquid in the connecting channel may not be discharged from the gap, but may be discharged to the outside of the two connecting channels or the second cavity through the liquid inlet of the hydrophobic channel.

In some other embodiments, there is no clear division between the sealing element and the drainage element. For example, as shown in Figures 31-32, there is no sealing ring on the sealing element 5028, and the drainage element 5027 and the sealing element 5028 are located on the extension section of the connection structure 5023. One end of the connection structure 5023 is connected to the first cover body 502, and the other end is connected to the sealing element 5028 or is the end of the connection structure. The sealing element 5028 is connected to the drainage element 5027. The liquid inlet 5025 of the liquid-repelling channel is located at the end of the drainage element, and the receiving cavity is located in the drainage element or in the sealing element, or in the connection structure. When the connection structure, the sealing element and the drainage element are hollow structures, the liquid outlet of the liquid-repelling channel is connected to the receiving cavity. Referring to the above description, when such a drainage element 5027 enters the connection channel, the discharged liquid enters the liquid-repelling channel through the liquid inlet 5038 located at the end of the drainage element, and then enters the receiving cavity through the liquid outlet of the liquid-repelling channel. The size of the liquid inlet can be set to allow the liquid to pass smoothly, but the liquid entering the receiving cavity will not leak out from the liquid inlet due to the surface tension of the liquid at the liquid inlet. This is because once the drainage element enters the connecting channel 109, 209 through the opening 2091, 1091 of the connecting channel, the surface of the drainage element 5027 and the inner surface of the connecting channel 209 form a seal. At this time, the drainage element and the sealing structure are the same structure, and the drainage element plays a dual role of sealing the connecting channel and draining the liquid. As the drainage element moves in the connecting channel, a pressure will be applied to the liquid in the connecting channel, and the pressure will react to the drainage element, thereby increasing the difficulty of the drainage element 4027 entering the connecting channel. In order to reduce the reaction force of the liquid, the excess liquid is allowed to enter the liquid inlet 4025 of the hydrophobic channel, and then enter the receiving cavity 4029 located in the drainage structure 4027.

When the second cavity is separated from the device, part of the liquid sample in the second cavity is discharged because the liquid discharge element 1027 is located in the second cavity. When the second cavity is disassembled from the device, as shown in FIG13 , a certain amount of space is reserved in the second cavity, so that the liquid does not fill the second cavity. Thus, during disassembly, the liquid sample will not overflow from the second cavity, thereby reducing the risk of contaminating the outside world. In addition, due to the surface tension at the liquid inlet 3025, the liquid sample in the receiving cavity will not leak out through the liquid inlet 3025.

In some embodiments, such as shown in FIGS. 33-35, the original 5035 can be used as a drainage element and the sealing element 5028 is located on the connecting rod 5024. At this time, the drainage element and the sealing element are detachably connected, and the overall lateral size of the drainage element 5035 is smaller than the size of the sealing element 5028. For example, the diameter of the drainage element is smaller than the size of the sealing element 5028 (as shown in FIG. 33). The connection between the drainage element and the sealing element is a threaded connection. For example, as shown in FIGS. 35A and 35B, the sealing element 5028 is a hollow structure with an internal thread on the inner surface, and the drainage element 5035 has an upward extension section 5030 at one end, and an external thread is provided on the extension section. In this way, through the cooperation of the internal and external threads, the drainage element and the sealing element 5028 can be connected together. When the sealing element and the drainage element enter the connecting channel 209, since the size of the drainage element is smaller than the size of the connecting channel, the drainage element is easy to enter the connecting channel, and the excess liquid enters the first cavity through the gap between the drainage element and the connecting channel. After the sealing element seals the opening 2091 of the connecting channel 209, the liquid cannot enter the first cavity through the gap. As the sealing element enters the connecting channel, excess liquid enters the receiving cavity or the first cavity through the liquid inlet 4025 of the hydrophobic channel.

In some preferred embodiments, referring to Figures 33 and 35, the size of the drainage element 5035 is equal to the diameter of the sealing element 5028, or the size of the drainage element is smaller than the diameter of the sealing element, and the liquid inlet 5025 of the hydrophobic channel is arranged on the extension section 5030. As can be seen from Figure 34, the diameter of the place with the liquid inlet 5025 is smaller than the diameter of the sealing element 5028 and the diameter of the drainage element 5029, and a concave area is formed at the liquid inlet 5025. In this way, when the drainage element 5035 enters the connecting channel 209, the liquid discharged by the discharge structure 5029 is discharged through the liquid inlet 4025 of the hydrophobic channel at the concave portion. Similarly, as the liquid discharge element further enters the connecting channel and then enters the space of the second cavity, the sealing element seals the opening 2091 of the connecting channel and then enters the connecting channel. The liquid discharged by one or both of them can be discharged through the liquid inlet 5025 of the liquid-repellent channel, for example, discharged into the receiving cavity or the first cavity. It can be understood that the liquid discharge element is also a preferred method here, but not a necessary method for completing the present invention.

Movement of sealing or drain elements

As mentioned above, the sealing element seals the connecting channel, and the drainage element will also enter the connecting channel or the second chamber. These are all a process of movement. To start the movement of these sealing elements and drainage elements, it is necessary to use a certain external force or another mechanical structure to make the sealing element and/or drainage element move. Therefore, the sealing element and the drainage element can be moved in a linkage manner, for example, the movement of the sealing element drives the movement of the drainage element; for example, the movement of the drainage element drives the movement of the sealing element.

The so-called "linkage" here means that the movement of one object will directly or indirectly drive the movement of another object. Usually, the movement of the two objects is the same. For example, if one object rotates, the object it drives also rotates; for example, if one object moves in an insertion manner, the other object it drives also moves in an insertion manner. For another example, when an object moves from an initial position to an end position, during this movement, it drives another object to move from an initial position to an end position. Rotational motion can play a role in moving from an initial position to an end position. Of course, rotation and insertion can be used in combination or separately. Here, the meanings of movement and movement can be understood interchangeably.

The first cover body and the sealing element or the liquid discharge element move in a linkage manner, that is, the movement of the first cover body drives the movement of the sealing element, thereby driving the movement of the liquid discharge element. Alternatively, the first cover body and the liquid discharge element move in a linkage manner, that is, the movement of the first cover body drives the movement of the liquid discharge element, thereby driving the movement of the sealing element. In some preferred embodiments, the sealing element is located on the first cover body, and when the cover body covers the opening of the first cavity, the cover body drives the sealing element to seal the connecting channel to form a sealed state. As described above, the sealing element of the connecting channel is generally divided into three states, and the first state is that the sealing element will not contact the opening of the connecting channel. For example, as shown in Figure 22, the first cover body 202 is provided with a sealing element 2028, and when the cover body covers the opening 2031 of the first cavity 203, the sealing element 2028 is driven to enter the first cavity, and at this time, the sealing element does not contact the first opening 2091 (Figure 22) of the connecting channel, and at this time, the connecting channel connects the first cavity and the second cavity, and at the same time, the first cavity and the second cavity are liquid-connected through the channel. As the cover is closed onto the opening 2031 of the first cavity, the cover moves from top to bottom along the longitudinal axis of the first cavity, driving the sealing element to gradually close to the opening 2031 of the first cavity.

The first cover body is further covered, and the sealing element 2028 contacts the first opening 2091 of the connecting channel 209, thereby sealing the opening (Figure 23). At this time, it can be considered that the connecting channel 209 is sealed. However, in order to ensure a more stable sealed connecting channel, it is hoped that the sealing element enters a distance into the connecting channel 209, thereby more stably sealing the connecting channel. At this time, the covering of the cover body is still required, thereby pushing the sealing element 2028 into the connecting channel. A similar process is shown in, for example, the process shown in Figures 12-27. Regardless of the type or form of sealing element, it is a preferred method for these sealing elements and the cover body to move simultaneously. Of course, the movement of the cover body and the movement of the sealing element can also be separate movements, such as the first cover body is used to cover the opening of the first cavity, thereby completing the covering process. The sealing element is instead completed by a separate movement to seal the connecting channel, and is not completed in coordination with the first cover body.

As for the drainage element, its function is to discharge part of the liquid in the second cavity. As mentioned above, when the second cavity is full of liquid, the drainage element is needed to discharge the liquid. However, if the second cavity is not full of liquid, the drainage element may not be needed at this time. Therefore, the drainage element is a preferred mode of the present invention, but not a necessary mode. When the drainage element is needed, the drainage element and the cover body can be connected as an integrated structure, so that the movement of the cover body drives the movement of the drainage element, thereby inserting it into the second cavity to discharge the liquid. Of course, as mentioned above, the sealing element and the drainage element are two different elements, and the drainage element enters the second cavity before the sealing element. In a preferred mode, the drainage element enters the connecting channel before the sealing element, thereby entering the second cavity. For such a design, the drainage element is located at the end of the sealing element, further away from the first cover body, so as to achieve such a functional design.

Therefore, in some preferred embodiments of the present invention, the present invention provides a cover body, on which a sealing element for sealing the connecting channel is arranged. In some preferred embodiments, a sealing ring is arranged on the sealing element. In some preferred embodiments, the materials of the sealing element and the connecting channel are the same or different. In some preferred embodiments, the sealing element is made of a flexible material, and the connecting channel is made of a rigid material. In some preferred embodiments, the sealing element is connected to the first cover body as an integral structure through a connecting rod. In some preferred embodiments, the sealing element also includes an opening for a lyophobic channel. In some preferred embodiments, the opening of the lyophobic channel is located below the sealing element, or the opening of the lyophobic channel enters the connecting channel before the sealing element. In some preferred embodiments, the cover body also includes a receiving chamber, which is in liquid communication with the lyophobic channel. The receiving chamber is connected to the liquid outlet of the lyophobic channel. In some preferred embodiments, the receiving chamber is located in the sealing element.

In some other preferred embodiments, a drainage element is further provided on the first cover body, and the drainage element is further away from the first cover body than the sealing element. Alternatively, a drainage element is provided under the sealing element, or the sealing element and the drainage element are provided so that the drainage element enters the second cavity before the sealing element, or the drainage element enters the connecting channel before the sealing element. Alternatively, a connecting rod is provided on the cover body to connect the first cover body and the sealing element, and the sealing element is connected to the drainage element. Alternatively, the connecting rod, the sealing element and the drainage element are an integrated structure.

In another way, if the first cavity and the second cavity are not in a liquid flow state at the beginning, but after the first cavity collects the liquid sample, the first cavity and the second cavity need to be in a liquid flow state. At this time, the cover body can have a first element that allows the first cavity and the second cavity to be in a flow state and a second element that allows the first cavity and the second cavity to be not in a fluid state. For example, the first cavity and the second cavity are not in a liquid flow state at the beginning. The realization is that the sealing element has sealed the first opening 1091 of the connecting channel at the beginning. If the cover body is linked with the first element and the second element, the first element is first allowed to contact the sealing element. For example, when the sealing element is a structure that is easy to puncture, the first element is a sharp puncture structure. After puncture, the liquid in the first cavity enters the second cavity. Subsequently, the second element is allowed to seal the first opening again, thereby realizing the change of the liquid flow state. Thus, the second cavity can be separated from the first cavity. It can be understood by ordinary technicians that the second element can be a replacement for any of the sealing elements described above, and can also include a liquid discharge element, or the setting of a liquid-repelling channel, etc. For example, in the specific embodiments shown in Figures 37-40 above.

The first cover and the second cover

The first cover body here is a cover body used to cover the first cavity, and the second cover body is used to cover the opening of the second cavity. A specific example of the cover body can be the shape of the cover body shown in Figure 1-28. Of course, the cover body actually plays the role of covering the opening of the first cavity, and the first cover body does not necessarily need to seal the opening of the first cavity. However, the main function of the second cover body is to seal the opening of the second cavity so that it does not cause leakage of the liquid sample. Therefore, in some ways, the second cover body is located on the first cover body, and the second cover body is detachably combined with the first cover body. For example, the second cover body is combined together by threads or other plug-in methods. When the second cover body is needed to seal, generally liquid-seal the opening of the second cavity, the second cover body is removed from the first cover body to seal the second cavity.

Methods for testing or collecting fluid samples

The present invention also provides a method for collecting a liquid sample, the method comprising providing the aforementioned device for collecting a liquid sample, the device comprising a first cavity and a second cavity, wherein the second cavity and the first cavity are connected in a detachable manner, the first cavity is used to collect the liquid sample, and the liquid sample is allowed to flow into the second cavity. In some preferred embodiments, when the second cavity collects the liquid sample, the second cavity and the first cavity are separated, so that the opening of the second cavity is covered with the second cover. In some preferred embodiments, before the first cavity and the cavity are separated, the first cavity is not in a state of fluid communication with the second cavity. In some preferred embodiments, a sealing element is used to isolate the first cavity and the second cavity, so that the first cavity and the second cavity are not in a flow state.

In some preferred embodiments, the first chamber and the second chamber are connected together through a connecting channel, wherein the first opening of the connecting channel is in liquid communication with the first chamber, and the second opening of the connecting channel is in liquid communication with the second chamber. The second chamber is separated from the first chamber by separating the second chamber from the connecting channel; or, the second chamber is detachably connected to the connecting channel, while the connecting channel is not detachably connected to the first chamber; or, the second chamber is detachably connected to the connecting channel, and the connecting channel is also detachably connected to the first chamber.

In some embodiments, when the second cavity is detachably connected to the first cavity through the connecting channel, the sealing element is allowed to seal the connecting channel. Therefore, in some preferred embodiments, the device further includes a sealing element, and before the second cavity is separated from the first cavity, the sealing element is allowed to seal the connecting channel. In some preferred embodiments, the device further includes a cover body, and the cover body and the sealing element are connected as an integral structure, so that when the cover body covers the opening of the first cavity, the cover body drives the sealing element to seal the first opening of the connecting channel. In some preferred embodiments, the cover body drives the sealing element to enter the connecting channel. In some preferred embodiments, after the sealing element seals the connecting channel, the second cavity is separated from the first cavity. In some preferred embodiments, a liquid discharge element for discharging part of the liquid in the second cavity is also provided on the cover body, and the cover body drives the liquid discharge element to enter the second cavity. In some preferred embodiments, a sealing element and a liquid discharge element are provided on the cover body, and the liquid discharge element enters the second cavity before the sealing element. In some preferred embodiments, the device further includes a liquid-repelling channel, so that the liquid sample discharged by the liquid discharge element is discharged out of the second cavity through the liquid-repelling channel. In some preferred embodiments, the sealing element is allowed to enter the connecting channel, and the liquid discharged by the sealing element is discharged to the outside of the connecting channel through the liquid-repelling channel. In some preferred embodiments, the liquid discharged by the sealing element or the liquid-discharging element is discharged to the first cavity through the liquid-repelling channel. In some preferred embodiments, a receiving cavity is provided on the cover body, and the receiving cavity is in liquid communication with the liquid-repelling channel, wherein the liquid discharged by the sealing element or/and the liquid-discharging element is discharged to the receiving cavity through the liquid-repelling channel.

In some embodiments, the lyophobic channel has a liquid inlet and a liquid outlet, allowing the liquid discharged by the sealing element and/or the liquid discharge element to enter the liquid inlet and then enter the receiving chamber through the liquid outlet of the lyophobic channel.

In some other embodiments, a sealing element is provided on the cover body, and when the opening of the first cavity is closed by the cover body, the sealing element is driven to seal the connecting passage. In some embodiments, if the first cover body leaves the opening of the first cavity again, the sealing element does not remain in the connecting passage, and the sealing element is separated from the cover body.

On the other hand, the present invention provides a method for detecting whether there is an analyte in a liquid sample, wherein the method includes a liquid collection device of any of the above-mentioned methods, and after the first cavity collects the liquid sample, the liquid sample from the first cavity is tested with a test element. After the test result is obtained, the second cavity is separated from the first cavity, and the separation is performed in any of the above-mentioned methods. In some specific methods, the device also includes a detection cavity for accommodating the test element, and the detection cavity is in flow communication with the first cavity. After the first cavity collects the liquid sample, the liquid flows into the detection cavity. When the detection cavity includes a test element, after the test element completes the test, the second cavity is separated from the first cavity. In some preferred methods, the liquid sample is allowed to enter the detection cavity from the first cavity first, and then enter the second cavity. Such a structure is just like the structural design described above, so as to avoid the liquid entering the detection cavity from also entering the second cavity, thereby contaminating the liquid sample in the second cavity.

Detection chamber

The detection chamber in the present invention is used to analyze the liquid sample from the first chamber to determine whether the substance to be analyzed exists. The detection chamber may not have a detection device. Generally, the detection chamber includes a test element, which contacts the liquid sample to perform an assay or test on the liquid sample. In traditional products, when manufacturing a device with a detection chamber, generally, the test element is first made or the test element is set on a carrier, and then the test element is inserted into the detection chamber, and then the detection chamber is sealed. In this case, the detection chamber generally has an opening to allow the test element to enter and exit the detection chamber. For example, as shown in Figures 1 and 9, the detection chamber 105 has an opening 1051 at a position close to the opening 1031 of the first chamber 103, and the test element (not shown) placed on the test carrier 106 is located in the card slot 1061 of the test carrier, and then the carrier 106 is inserted into the detection chamber through the opening of the detection chamber. Normally, after being inserted into the detection cavity, the opening 1051 of the detection cavity needs to be sealed. This sealing effect and quality requirements are very high. As described above, the entire detection device or the collection device needs to be transported and packaged together. In order to prevent the liquid in the detection cavity or the liquid in the first cavity from leaking, it is necessary to strictly seal any place where leakage may occur, and each product needs to be tested for sealing, which increases the production cost. However, after adopting the second cavity with secondary confirmation of the present invention, these places that were previously considered to require good sealing effects do not need to be deliberately considered. This kind of sealing only requires temporary sealing, and does not require permanent sealing. For example, as shown in Figure 9, for the sealing of the opening 1051 of the detection amount, conventional sealing can be used, such as heat sealing with a film, as long as it is ensured that the film is airtight or leak-proof during the detection. After the detection is completed, the second cavity is separated from the first cavity, and the first cavity and the detection cavity can be treated as discarded, without the need to store and transport the entire detection device.

Example 1

Now, how to assemble and operate the detection device of the present invention will be described in conjunction with specific implementation examples.

For example, the device shown in Figures 1-3, 6-14 includes a first cavity 103 and a second cavity 104, and an opening 1031 in the first cavity 103 for introducing a liquid sample. As shown in Figure 1, the first cavity is surrounded by a side wall and a bottom, and there is a raised area at the bottom of the first cavity. For example, as shown in Figure 9, the raised area is located in the center of the entire bottom, and an opening 1091 is set in the raised area, which has a connecting channel 109. The first opening 1091 of the connecting channel 109 is connected to the first cavity 103, and the other opening 1092 is connected to the opening 1042 of the second cavity. A groove is formed around the raised area inside the first cavity, and the groove forms a liquid sample collection area 1035, 1036 (as shown in Figure 7). A thread structure 1101 is provided on the wall 110 opposite to the outside of the connecting channel 109 near the second opening 1092, and a thread structure 1041 is provided on the outer wall of the opening 1042 of the second cavity 104, and the thread and the thread 1101 on the wall 110 form a rotational fit, so that the second cavity 104 forms a detachable fit with the first cavity through the connecting channel 109. At the same time, it also includes a detection cavity 105, which is in liquid communication with the first cavity through the through hole 1038. A test element is included in the detection cavity. The test element is arranged in the card slot 1061 of the test carrier 106. Generally, the sample application area of the test element is located in the area of the test carrier close to the bottom of the second cavity, or close to the bottom 1051 of the detection cavity, and the water absorption area of the test element is close to the other end of the detection cavity (the end close to the opening 1031 of the first cavity).

A cover 102 is also provided, with a connecting rod 1023 connected at the center of the cover, a sealing element 1028 arranged at the end of the connecting rod, and a sealing ring 108 arranged on the sealing element. At the same time, a liquid discharge element 1027 is arranged under the sealing element, and the liquid discharge element 1027, the sealing element and the connecting rod 1023 are formed as one body, and only the functional area is divided. Generally, the length of the connecting rod 1023, the sealing element 1038 and the liquid discharge element 1027 is slightly greater than the distance from the opening 1031 of the first cavity 103 to the opening 1042 of the second cavity 104, so that the liquid discharge element 1027 can enter the second cavity 104, thereby excluding part of the liquid sample in the second cavity. At the same time, a liquid inlet 1025 (Figures 2 and 3) of the liquid-repelling channel is arranged below the sealing element 1028. The liquid inlet 1025 can be located between the liquid discharge element 1027 and the sealing element 1028. At the same time, the sealing element, the liquid discharge element and the connecting rod are hollow structures, and the interior includes a receiving chamber 1029 to collect excess liquid samples. When in use, the opening of the first cavity is first allowed to collect the liquid sample. As the liquid sample enters, it is gathered at the bottom of the first cavity, and then enters the detection cavity through the through hole 1038. The liquid sample entering the detection cavity contacts the sample reagent area of the test element, thereby performing an assay and detection. As the liquid increases, the liquid sample enters the second cavity through the opening 1091 of the connecting channel, and then the liquid sample gradually fills the second cavity 104, and then floods the first opening 1091 of the connecting channel, and finally the liquid level is higher than the first opening 1091 of the connecting channel 109. This is the time to stop collecting the liquid sample. Subsequently, the first cover body 102 is used to cover the opening 1031 of the first cavity 103. As the cover body covers the opening 1031, the cover body rotates and covers, driving the sealing element 1028, the liquid discharge element 1027 and the liquid inlet 1025 of the hydrophobic channel to approach the opening of the connecting channel 109 (as shown in Figures 10, 11 and 12). As the cover body rotates, the liquid discharge element 1027 first enters the connecting channel 109, and at this time, the sealing ring of the sealing element is not close to the first opening 1091 of the connecting channel. The liquid can enter the first cavity 103 through the gap between the liquid discharge element 1027 and the connecting channel 109. As the sealing element enters the connecting channel 109, the liquid discharged at this time enters the receiving cavity 1029 through the liquid inlet 1025 of the hydrophobic channel, thereby discharging excess liquid samples and reducing the pressure of the sealing element entering the connecting channel, so that it is easier to obtain a better seal. After the liquid discharge element enters the second cavity, at this time, the sealing element also seals the connecting channel 109. At this time, the test element of the detection chamber has been tested for the first time. If it is necessary to retain the remaining sample for a second confirmation test, the second chamber is separated from the first chamber by rotating the second chamber. Since the sealing element seals the connection channel, the liquid sample in the first chamber will not leak out. Then the second cover 101 disposed on the first cover 102 is used to seal the opening 1042 of the second chamber 104 (as shown in Figures 14 and 13). In this way, the second cover can be stored or packaged and transported to a testing agency for a second confirmation test.

Example 2

For example, as shown in FIGS. 15-18, 23-28, the device includes a first cavity 203 and a second cavity 204, and an opening 2031 in the first cavity 203 for introducing a liquid sample. As shown in FIG. 16, the first cavity is surrounded by a side wall and a bottom, and a raised area is provided at the bottom of the first cavity. For example, as shown in FIG. 24, the raised area is located in the center of the entire bottom, and an opening 2091 is provided in the raised area, which has a connecting channel 209, and the first opening 2091 of the connecting channel 209 communicates with the first cavity 203, and the other opening 2092 communicates with the opening 2042 of the second cavity. A groove is formed around the raised area inside the first cavity, and the groove forms a liquid sample collection area 2035, 2034 (as shown in FIG. 24). A thread structure 2101 is provided on the wall 210 opposite to the outside of the connecting channel 209 near the second opening 2092, and a thread structure 2043 is provided on the outer wall of the opening 2042 of the second cavity 204. The thread and the thread 2101 on the wall 210 form a rotational fit, so that the second cavity 204 forms a detachable fit with the first cavity through the connecting channel 209. At the same time, a carrier 206 is provided, on which there are multiple channels with one end sealed 2062 and the other end open 2063, one or more test strips are arranged in the channel, and the sample application area of the test strip is located at one end of the opening 2063. There are one or more channels for accommodating the test strip in the carrier 206, and each channel is provided with a test element. When there are multiple channels, test elements of different analytical substances can be arranged in each channel, so that multiple analyzed substances can be detected using the same sample. Such a carrier 206 is placed in the first cavity 203, and two limiting strips 2032 and 2033 are provided on the wall of the cavity 203. The carrier 206 is inserted or snapped into the two limiting grooves, so that one end 2065 with the opening channel is close to the bottom of the first cavity, and one end 2064 with the sealing channel is close to the opening 2031 of the first cavity (Figure 16). When the liquid sample flows into the first cavity through the opening 2031 of the first cavity, the liquid sample contacts the sample application area of the test strip, thereby completing the detection.

A cover 202 is also provided, wherein a connecting rod 2023 is connected to the center of the cover, a sealing element 2028 is provided at the end of the connecting rod, and a sealing ring 208 is provided on the sealing element. Meanwhile, a liquid discharge element 2027 is provided under the sealing element, and the liquid discharge element 2027, the sealing element 2028 and the connecting rod 2023 are formed as one body, and only the functional area is divided unused. Generally, the length of the connecting rod 2023, the sealing element 2028 and the liquid discharge element 2027 is slightly greater than the distance from the opening 2031 of the first cavity 203 to the opening 2042 of the second cavity 204, so that the liquid discharge element 2027 can enter the second cavity 204, thereby excluding part of the liquid sample in the second cavity. Meanwhile, a liquid inlet 2025 (Figures 18 and 26) of the liquid-repelling channel is provided below the sealing element 2028. The liquid inlet 2025 can be located between the liquid discharge element 2027 and the sealing element 2028.

At the same time, the sealing element, the liquid discharge element and the connecting rod are hollow structures, and the interior includes a receiving chamber 2029 to collect excess liquid samples. When in use, the opening of the first cavity is first allowed to collect the liquid sample. As the liquid sample enters, it is collected at the bottom of the first cavity, and then contacts the application area of the test element on the carrier for testing and detection. As the liquid increases, the liquid sample enters the second cavity through the opening 2091 of the connecting channel, and then the liquid sample gradually fills the second cavity 204, and then floods the first opening 2091 of the connecting channel, and finally the liquid level is higher than the first opening 2091 of the connecting channel 209. As the liquid is added, it reaches the set position and stops accepting the liquid sample. This is the time to stop collecting the liquid sample. Subsequently, the first cover body 202 is used to cover the opening 2031 of the first cavity 203. As the cover body covers the opening 2031, the cover body rotates to cover, driving the sealing element 2028, the liquid discharge element 2027 and the liquid inlet 2025 of the liquid-repellent channel close to the opening of the connecting channel 209 (as shown in Figure 22). As the cover rotates, the liquid discharge element 2027 first enters the connecting channel 209. At this time, the sealing ring of the sealing element is not close to the first opening 2091 of the connecting channel, and the first opening 2091 of the connecting channel is not sealed. The liquid can enter the first cavity 203 through the gap 809 between the liquid discharge element 2027 and the connecting channel 209. As the sealing element enters the connecting channel 209 to seal the connecting channel, the liquid discharged by the sealing element or the liquid discharge element enters the receiving cavity 2029 through the liquid inlet 2025 of the liquid-repelling channel, thereby removing excess liquid samples and reducing the pressure of the sealing element entering the connecting channel, so that it is easier to obtain a better seal. After the liquid discharge element enters the second cavity, the sealing element also seals the connecting channel 209. At this time, the test element of the detection cavity has been tested for the first time or the first time. After it is considered necessary to retain the remaining sample for secondary confirmation testing, the second cavity is separated from the first cavity by rotating the second cavity. Since the sealing element seals the connecting channel, the liquid sample in the first cavity will not leak out. Then, the second cover 201 disposed on the first cover 202 is used to seal the opening 2042 (as shown in FIG. 24 ) of the second cavity 204. In this way, the second cavity can be stored or packaged and transported to a testing institution for secondary confirmation testing.

Example 3

For example, as shown in the device of Figures 25-30, the device includes a first cavity 303 and a second cavity 304, and an opening 3031 in the first cavity 303 for introducing a liquid sample. As shown in Figure 27, the first cavity is surrounded by a side wall and a bottom, and a raised area is provided at the bottom of the first cavity. For example, as shown in Figure 27, the raised area is located in the center of the entire bottom, and an opening 3091 is provided in the raised area, and a connecting channel 309 is provided. The first opening 3091 of the connecting channel 309 communicates with the first cavity 303, and the other opening 3092 communicates with the opening 3042 of the second cavity. A groove is formed around the raised area inside the first cavity, and the groove forms a liquid sample collection area 3035, 3036 (as shown in Figure 27). The outer wall and inner wall near the second opening 3092 of the connecting channel 309 are smooth. A tray structure 1004 is provided, and the tray structure has an internal thread 10041, and the internal thread is threadedly matched with the external thread at the bottom of the first cavity.

The second cavity 304 is located on a base tray 1004, and the base tray 1004 is detachably connected to the first cavity, and the second cavity 304 is also detachably combined with the base tray 1004. Specifically, the tray structure 1004 has an internal thread, and the internal thread cooperates with the external thread 3031 extending from the bottom of the first cavity 303, so as to realize the detachable combination of the tray structure 1004 and the first cavity 303. In this way, if there is still a connecting channel, as shown in FIG. 27, the connecting channel 309 can still have a first opening 3091 in liquid flow with the first cavity and a second opening 3092 in liquid flow with the second cavity, and the connecting channel has an extension section 3098, which extends deep into the opening 3052 of the second cavity, contacts with the inner wall of the opening 3041, and can be snapped together, that is, the outer diameter of the extension area matches the inner diameter of the opening 3041. Although the second cavity and the first cavity can also be connected by the connecting channel 109 as shown in FIG. 27, this connection does not need to be very strong, and does not need to be as tight as in FIG. 8-9 (through threads, etc.). This is because the tray structure 1004 is connected to the first cavity by the threads 10041.

103 of the extension section cooperates, so no matter how much liquid sample is collected by the second cavity 304, it will not cause leakage between the connecting channel 109 and the second cavity opening 1042. Therefore, the inner diameter of the connecting channel 109 can be smaller than the inner diameter of the opening 1042 of the second cavity, so that the connecting channel can be inserted into the opening 3042 of the second cavity, and this insertion method can be easily inserted (as shown in Figure 27). Only the outer edge of the opening 3042 is provided with a thread for the second cover body to cover (as shown in Figure 27). At this time, the connection between the connecting channel and the opening of the second cavity only needs to ensure that there is no leakage when collecting liquid samples, that is, the liquid can enter the second cavity, without more structural restrictions. This connection can be in the form of snap-on, piston-type, and lock. In fact, the detachable combination, combination or engagement of the first cavity and the second cavity is completed in an indirect way.

After the collection is completed, the connection channel is sealed and/or the second cavity is drained according to the method described below. If a second confirmation test is required, the lower tray structure 1004 is separated from the first cavity 103, for example, by reversely rotating the tray and cooperating with the thread structure at the bottom of the first cavity. At this time, the second cavity 104 located on the tray is also separated from the first cavity 103 along with the tray structure, as shown in Figure 27. At this time, the second cover 101 is removed to cover the opening 3042 of the second cavity. Then the second cavity is separated from the tray 1004 (as shown in Figure 29). This is because the bottom of the second cavity and the bottom of the tray have a snap-fit structure 10042, so the tray and the second cavity will be separated from the first cavity 103 together. Then, after removing the tray 1004 from the second cavity 304, the tray 1004 is reconnected and combined with the first cavity 103 separately. At this time, the integrity of the first cavity is still maintained, and the second cavity can be sent to the confirmed testing agency for a second confirmation test. In order to allow the second cavity 304 to be separated from the first cavity as the tray moves, a snap ring 10042 is provided on the tray. The shape of the snap ring is adapted to the shape of the cavity of the second cavity 304. For example, the cavity of the second cavity is U-shaped, and the snap ring 10042 is also U-shaped. In this way, when the tray structure 1004 rotates, the second cavity 304 is also driven to rotate together. Since the second cavity and the snap ring can be slightly tightly matched, the second cavity 304 and the tray structure 1004 can naturally be separated from the first cavity 303 together. Of course, in some embodiments, the second cavity is a structure similar to a cube.

Four snap structures are arranged on the tray, so that the second cavity and the snap structures are snapped together, so that the movement of the tray drives the movement of the second cavity, and then the second cavity is separated from the first cavity.

A cover body 302 is also provided, wherein a connecting rod 3023 is connected to the center of the cover body, a sealing element 3028 is arranged at the end of the connecting rod, a sealing ring is arranged on the sealing element, the sealing ring and the sealing element are made of the same material, and are injection molded in one step. At the same time, a liquid discharge element 3027 is arranged under the sealing element, and the liquid discharge element 3027, the sealing element and the connecting rod 3023 are formed as one body, and only the functional area is divided unused. Generally, the length of the connecting rod 3023, the sealing element 3038 and the liquid discharge element 3027 is slightly greater than the distance from the opening 3031 of the first cavity 303 to the opening 3042 of the second cavity 304, so that the liquid discharge element 3027 can enter the second cavity 304, thereby removing part of the liquid sample in the second cavity. At the same time, a liquid inlet 3025 (Figure 27) of the liquid-repelling channel is arranged below the sealing element 3028. The liquid inlet 3025 can be located between the liquid discharge element 3027 and the sealing element 3028, or on the liquid discharge element. At the same time, the sealing element, the liquid discharge element and the connecting rod are hollow structures, and the interior includes a receiving chamber 3029 to collect excess liquid samples. When in use, the opening of the first cavity is first allowed to collect the liquid sample, and as the liquid sample enters, it is gathered at the bottom of the first cavity. As the liquid increases, the liquid sample enters the second cavity through the opening 1091 of the connecting channel, and then the liquid sample gradually fills the second cavity 304, and then floods the first opening 3091 of the connecting channel, and finally the liquid level is higher than the first opening 3091 of the connecting channel 309. This is the time to stop collecting liquid samples. Subsequently, the first cover body 302 is used to cover the opening 3031 of the first cavity 303. As the cover body covers the opening 3031, the cover body rotates to cover, driving the sealing element 3028, the liquid discharge element 3027 and the liquid inlet 3025 of the hydrophobic channel close to the opening of the connecting channel 309. As the cover body rotates, the liquid discharge element 3027 first enters the connecting channel 309, and at this time, the sealing ring of the sealing element is not close to the first opening 3091 of the connecting channel. The liquid can enter the first cavity 303 through the gap between the liquid discharge element 3027 and the connecting channel 309. As the sealing element enters the connecting channel 309, the discharged liquid enters the receiving cavity 3029 through the liquid inlet 3025 of the liquid-repelling channel, thereby discharging excess liquid sample and reducing the pressure of the sealing element entering the connecting channel, thereby making it easier to obtain a better seal. When the liquid discharge element enters the second cavity, the sealing element also seals the connecting channel 309.

At this time, the liquid in the first cavity can be used for subsequent initial testing. If it is necessary to retain the remaining sample for secondary confirmation testing, the tray structure can be rotated to separate the tray structure from the first cavity, thereby driving the separation of the second cavity from the first cavity, so that the second cavity and the first cavity are separated. Since the sealing element seals the connecting channel, the liquid sample in the first cavity will not leak out. Then the second cover body 301 set on the first cover body 302 is used to seal the opening 3042 of the second cavity 304 (as shown in Figure 28). At this time, the tray structure and the second cavity can be packaged together and sent to the testing agency for secondary testing. Alternatively, the second cavity is removed from the tray and packaged for secondary confirmation testing (Figure 29). At this time, the tray is transferred to the first cavity again to form a completed structure (Figure 30).

The following contents of the present invention are also a part of the technical solution of the present invention.

1. A device for collecting liquid samples comprises: a first chamber for collecting liquid samples; and a second chamber for collecting liquid samples for confirmation and detection; wherein the first chamber and the second chamber are detachably combined, assembled or connected.

2. The device according to claim 1, wherein the first chamber and the second chamber are in a state of liquid communication.

3. The device according to claim 1, wherein when the second cavity does not leave the first cavity, the first cavity and the second cavity are in a liquid communication state.

4. The device according to claim 1, wherein before the second cavity leaves the first cavity, or immediately before the second cavity leaves the first cavity, the first cavity and the second cavity are not in a liquid flow state.

5. The device according to claim 1, wherein the first chamber and the second chamber are assembled together in a detachable manner.

6. The device according to claim 1, wherein the second chamber is located below the first chamber, or, when collecting liquid, the liquid first enters the first chamber and then enters the second chamber, or, the second chamber is downstream of the first chamber; or, when collecting liquid, the liquid enters the first and second chambers at the same time; or, part of the liquid sample enters the first chamber and another part of the liquid sample enters the second chamber.

7. The device according to claim 1, wherein the fluid flow state between the first cavity and the second cavity comprises one or more of the following states: fluid flow state, fluid non-flow state.

8. The device according to claim 1, wherein the first chamber and the second chamber are first in a state where liquid does not flow, then in a state where liquid flows, and finally in a state where liquid does not flow again.

9. The device according to claim 1, wherein the first chamber and the second chamber are first in a liquid flow state and then in a liquid non-flow state.

10. The device according to any one of claims 1-9, wherein when the first chamber and the second chamber are in a liquid circulation state, the first chamber and the second chamber are detachably combined together, or, when the first chamber and the second chamber are in a liquid non-circulating state; the first chamber and the second chamber can be separated or have been separated.

11. The device according to claim 10, wherein when the first chamber and the second chamber are in a state where liquid does not flow therebetween, the first chamber and the second chamber are detachably combined together.

12. The device according to any one of claims 1-11, wherein the device further comprises a sealing element, which can change the liquid flow state between the first cavity and the second cavity; or, the device further comprises a puncturing element, which can change the liquid non-flow state to the liquid flow state; or, the device further comprises a sealing element and a puncturing element, wherein the puncturing element firstly puts the first cavity and the second cavity in a liquid flow state, and then puts the liquid in a non-flow state through the sealing element.

13. The device according to claim 12, wherein the sealing element prevents the first cavity and the second cavity from being in a liquid communication state before the second cavity leaves the first cavity, or before the second cavity is separated from the first cavity or immediately before being separated from the first cavity.

14. The device according to any one of claims 1-13, further comprising a connecting channel, wherein the second chamber is detachably connected, combined or assembled with the first chamber through the connecting channel, or/and the second chamber is in liquid communication or not in liquid communication with the first chamber through the connecting channel.

15. The device according to any one of claims 1-13, wherein the device further comprises a connecting channel; the second chamber is in liquid communication with the first chamber through the connecting channel.

16. The device according to claim 15, wherein the connecting passage is not sealed when the second chamber does not leave the first chamber; or the connecting passage is sealed before or after the second chamber leaves the first chamber.

17. The device according to claim 16, wherein the connecting channel is sealed by a sealing element.

18. The device according to claim 15, further comprising a sealing element for sealing the channel so that no liquid is communicated between the first chamber and the second chamber.

19. The device according to any one of claims 1-13, or any one of claims 17-18, wherein the device further comprises a liquid-repelling channel, and the liquid-repelling channel has a liquid inlet.

20. The device according to claim 19, wherein the liquid inlet is located below the sealing element, or, when the sealing element is used to seal the channel, the liquid inlet approaches the connecting channel before the sealing element, or, when the sealing element enters the connecting channel, the liquid inlet is located below the horizontal position of the sealing element; or, when the sealing element enters the connecting channel, the liquid inlet enters the connecting channel before the sealing element.

21. The device according to claim 20, wherein the liquid inlet is located on the sealing element.

22. The device according to claim 20, wherein the liquid inlet is located on a side wall of the connecting channel.

23. The device according to claim 20, wherein the liquid-repellent channel further has a liquid outlet, and the liquid outlet is in liquid communication with a receiving chamber.

24. The device according to claim 23, wherein the receiving cavity is located on the sealing element.

25. The device according to claim 20, wherein the liquid-repellent channel further has a liquid outlet, and the liquid outlet is in fluid communication with the first chamber.

26. The device according to any one of claims 1 to 25, wherein the device further comprises a drainage element for discharging part of the liquid sample in the second chamber.

27. The device according to claim 26, wherein the drainage element is located in the second chamber or partially located in the second chamber before the second chamber is separated from the first chamber.

28. The device according to claim 26, wherein after the second chamber is separated from the first chamber, the second chamber does not contain the drainage element or does not contain part of the drainage element.

29. The device according to any one of claims 12-25, wherein the device further comprises a liquid discharge element for discharging part of the liquid sample in the second chamber; the liquid discharge element is located on the sealing element or is integrally connected to the sealing element;.

30. The device according to claim 29, wherein the drainage element enters the connecting channel before the sealing element, or the drainage element enters the second chamber before the sealing element; or, when the sealing element is located in the connecting channel, the drainage element is located in the second chamber.

31. The device according to claim 29, wherein the device further comprises a liquid-repelling channel having a liquid inlet, wherein the liquid inlet is located on the liquid discharge element; or, the device comprises a receiving chamber, wherein the receiving chamber is located on the liquid discharge element.

32. The device according to claim 28, wherein the liquid inlet is in liquid communication with a receiving chamber, and the receiving chamber is located in the liquid discharge element.

33. The device according to claim 17, wherein a partial area of the sealing element is used as a drainage element for draining part of the liquid in the second chamber.

34. The device according to claim 33, wherein the partial sealing element is used to seal the connecting channel, and the partial sealing element is used to discharge part of the liquid in the second chamber.

35. The device according to claim 33, wherein the partial sealing element is used to seal the connecting channel, and the partial sealing element is located in the second cavity.

36. The device according to claim 29, wherein the vertical projection area of the drainage element is located within the vertical projection area of the sealing element.

37. The device according to any one of claims 12-19 or 17-18, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel has a liquid inlet, and the vertical projection of the liquid inlet is located within the vertical projection area of the sealing element.

38. The device according to any one of claims 1-11, wherein the device further comprises a first and a second sealing element, and the first sealing element or the second sealing element can change the liquid flow state between the first chamber and the second chamber.

39. The device according to claim 37, wherein the first sealing element is used to seal the connecting channel and the second sealing element is used to seal the opening of the second cavity, or the first sealing element is used to seal the opening of the second cavity and the second sealing element is used to seal the first opening of the connecting channel.

40. The device according to claim 38, wherein, while or after the opening of the second cavity is sealed by the first sealing element, the position of the second cavity is changed from the first position to the second position; or the second cavity is detached from the second cavity.

41. The device according to any one of claims 17-39, wherein the sealing element or the drainage element is moved in conjunction with each other.

42. The device according to claim 41, wherein the linkage is used to cover the first cavity opening cover for movement.

43. A device according to claim 41 or 42, wherein the movement is rotational movement.

44. A method for collecting a liquid sample, the method comprising:

A collecting device is provided, which comprises a first cavity for collecting a liquid sample and a second cavity for collecting the liquid sample, wherein the first cavity and the second cavity are detachably combined, coupled or assembled; before collecting the liquid sample, the first cavity and the second cavity are in a liquid communication state, so that the liquid entering the first cavity can flow into the second cavity.

45. The method according to claim 44, wherein after the first chamber collects the liquid sample, the first chamber and the second chamber are not in a liquid communication state.

46. The method of claim 45, wherein the second chamber is separated from the first chamber, or the first chamber is separated from the second chamber, when the first chamber and the second chamber are not in a liquid communication state.

47. The method according to claim 44, wherein the liquid sample entering the second chamber originates from the liquid sample in the first chamber; the liquid is allowed to enter the first and second chambers simultaneously; or part of the liquid sample is allowed to enter the first chamber and another part of the liquid sample is allowed to enter the second chamber.

48. According to the method of claim 44, the first chamber and the second chamber are connected by a connecting channel, wherein the second chamber and the connecting channel are detachably combined, coupled or assembled; or, through the connecting channel, the first chamber and the second chamber are in a liquid flow state.

49. The method of claim 48, wherein preventing the first chamber and the second chamber from being in a liquid communication state is achieved by sealing the passage with a sealing element.

50. The method of claim 49, wherein the passageway has a first opening in fluid communication with the first chamber and a second opening in fluid communication with the second chamber, wherein the sealing element seals the first opening of the passageway.

51. The method of claim 50, wherein after allowing the sealing element to seal the first opening of the connecting channel, a portion of the sealing element is allowed to enter the channel.

52. The method according to any one of claims 44-51, wherein the device further comprises a lyophobic channel, the lyophobic channel comprising a liquid inlet.

53. The method according to claim 52, wherein, when a portion of the sealing element is allowed to enter the channel, the liquid sample expelled by the sealing element is expelled through the liquid inlet to the outside of the connecting channel or the second cavity, if the liquid sample exists.

54. The method according to claim 53, wherein the liquid sample discharged by the sealing element is discharged into the receiving chamber through the liquid-repellent channel.

55. The method according to claim 50, wherein the device further comprises a liquid-repellent channel, the liquid-repellent channel comprising a liquid inlet, and the liquid inlet enters the connecting channel before the sealing element.

56. The method according to any one of claims 48 to 56, wherein the device further comprises a drainage element for draining part of the liquid in the second chamber.

57. The method of claim 56, wherein, when a sealing element is present, the drainage element is introduced into or approached into the connecting channel before the sealing element.

58. The method of claim 57, wherein the drainage element is introduced into the second chamber, or a portion of the drainage element is introduced into the second chamber.

59. The method of claim 54, wherein the drainage element is not located in the second chamber after the second chamber is separated from the first chamber.

60. The method according to claim 57, wherein the drainage element is introduced into the second cavity while the sealing element is sealing the first opening of the connecting channel, or the sealing element is introduced into the connecting channel and the drainage element is introduced into the second cavity.

61. The method of claim 56, wherein the sealing element and the drainage element move in conjunction with each other.

62. According to the method of claim 61, the linkage is achieved by a cover body covering the first cavity.

1. A device for collecting liquid samples comprises: a first cavity for collecting liquid samples; and a second cavity for collecting liquid samples for confirmation and detection; wherein the first cavity has an opening for receiving the liquid sample, and the second cavity has an opening for receiving the liquid sample from the first cavity.

2. The device according to claim 1, wherein the device further comprises a tray structure, the second cavity is detachably arranged on the tray structure, and the tray structure is detachably combined with the first cavity.

3. The device according to claim 2, wherein when the tray structure is combined with the first cavity, the second cavity and the second cavity are in a liquid communication state.

4. The device according to claim 3, wherein the first cavity comprises a hole, and the hole is in a liquid flow state with the opening of the second cavity; or, the liquid sample in the first cavity can flow into the second cavity by gravity of the liquid itself.

5. The device according to claim 3, wherein the hole is a first opening of a connecting channel, and the second cavity realizes a fluid communication state with the first cavity through the connecting channel; or the hole has an extended channel, and the second cavity realizes a fluid communication state with the first cavity through the extended channel. 6. The device according to claim 5, wherein the connecting channel or the extended channel has a first opening and a second opening, and the first opening is in fluid communication with the first cavity, and the second opening is in fluid communication with the second cavity.

7. The device according to claim 5 or 6, wherein the device further comprises a sealing element for sealing the connecting channel, the extended channel or the hole.

8. The device according to claim 7, wherein the sealing element can seal by sealing a first opening of the connecting channel or the extended channel or a part of the sealing element entering the connecting channel or the extended channel.

9. The device according to any one of claims 1-7, wherein the device further comprises a liquid-repellent channel.

10. The device according to claim 9, wherein the liquid-repellent channel comprises a liquid inlet, and the liquid inlet is located below the sealing element, or, when the sealing element is used to seal the connecting channel or the extension channel, the liquid inlet approaches the connecting channel or the extension channel before the sealing element, or, when the sealing element enters the connecting channel or the extension channel, the liquid inlet is located below the horizontal position of the sealing element; or, when the sealing element enters the connecting channel, the liquid inlet enters the connecting channel before the sealing element.

11. The device according to claims 1-7, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet, and a projection area of the liquid inlet is located within a projection area of the sealing element.

12. The device according to claim 10 or 11, wherein the liquid inlet is located on the sealing element.

13. The device according to claim 10, wherein the liquid inlet is located on a side wall of the connecting channel.

14. The device according to claim 13, wherein the liquid inlet is lower than the position of the connecting channel opening.

15. The device according to any one of claims 9 to 14, wherein the liquid-repellent channel further has a liquid outlet, and the liquid outlet is in liquid communication with a receiving chamber.

16. The device according to claim 15, wherein the receiving cavity is located on the sealing element.

17. The device according to any one of claims 9 to 14, wherein the liquid-repelling channel further comprises a liquid outlet, wherein the liquid outlet is in fluid communication with the first chamber.

18. The device according to claim 7, wherein the device further comprises a hydrophobic channel, wherein the hydrophobic channel comprises a liquid inlet, and part of the liquid forced by the sealing element enters the hydrophobic channel through the liquid inlet, thereby being discharged out of the channel and/or the second chamber.

19. The device according to claims 1-18, wherein the device comprises a liquid discharge element for discharging part of the liquid sample in the second chamber.

20. The device according to claim 19, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet, and the liquid inlet is located on the liquid discharge element.

21. The device according to claim 19, wherein the drainage element and the sealing element are integrated into a single structure, when the sealing element is provided.

22. The device according to claim 21, wherein when the sealing element is used to seal the passage, the drainage element enters the second chamber before the sealing element.

23. The device according to any one of claims 1-22, wherein the liquid-repellent channel comprises a liquid outlet, and the liquid outlet is in liquid communication with a receiving chamber.

24. The device according to claim 23, wherein when the portion of the sealing element enters the connecting channel, the receiving chamber is used to receive the liquid sample discharged by the sealing element entering the connecting channel.

25. The device according to claim 24, wherein the receiving chamber is located in a sealing element or a drainage element.

26. The device according to claim 21, wherein the projection area of the drainage element is located within the vertical projection area of the sealing element.

27. The device of claim 26, wherein the transverse diameter of the drainage element is smaller than the transverse diameter of the sealing element.

28. The device according to claim 27, wherein the connecting channel is cylindrical and the sealing element is also cylindrical.

29. The device according to any one of claims 1-28, wherein the device further comprises a first cover for covering the opening of the first cavity.

30. The device according to claim 29, wherein the cover body moves in conjunction with the sealing element, the latter the cover body moves in conjunction with the drainage element, or the cover body, the sealing element and the drainage element move in conjunction with each other.

31. The device according to claim 30, wherein when the first cover body covers the opening of the first cavity, the sealing element seals the first opening of the connecting channel or part of the element enters the connecting channel as the cover body is closed.

32. The device of claim 30, further comprising a drainage element, wherein the drainage element is connected to the sealing element.

33. The device of claim 32, wherein the drainage element is further away from the first cover than the sealing element.

34. The device according to claim 30, wherein the sealing element is connected to the first cover body through a connecting rod.

35. The device according to claim 34, wherein the sealing element is detachably connected to the connecting rod.

36. The device according to any one of claims 1-35, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet, and a projection area of the liquid inlet is located within a projection area of the sealing element.

37. The device according to claim 36, wherein the liquid inlet is farther from the first cover body than the sealing element.

38. The device according to claim 37, wherein the liquid inlet is located on the liquid discharge element.

39. The device of claim 37, wherein the drainage element or a portion of the drainage element is located in the second chamber when the sealing element seals the connecting channel.

1. A method for collecting liquid: the method comprising:

A device for collecting a liquid sample is provided, wherein the device comprises: a first cavity for collecting the liquid sample, wherein the first cavity has an opening for receiving the liquid sample; and

A second chamber for collecting a liquid sample for confirmation testing, the second chamber having an opening for receiving the liquid sample from the first chamber;

A tray structure, the tray structure comprising a second cavity, wherein the tray structure is detachably assembled, combined or combined with the first cavity;

The first cavity is used to collect the liquid sample, and the liquid sample is allowed to enter into a cavity through the opening of the first cavity.

2. The method of claim 1, wherein the first chamber has a hole, and the hole forms a liquid flow with the second chamber.

3. The method according to claim 2, wherein before the liquid is collected, the first chamber and the second chamber are brought into liquid communication through the hole.

4. The method according to claim 2, wherein, when collecting liquid, the liquid is allowed to enter the first chamber, and then the liquid is allowed to automatically flow from the first chamber through the hole into the second chamber; or, the liquid is allowed to enter the first chamber and the second chamber at the same time; or, part of the liquid is allowed to enter the first chamber, and the other part of the liquid is allowed to enter the second chamber.

5. The method according to claim 2, wherein the hole has an extended extension channel, part of the extended channel is located in the second cavity, or part of the opening of the second cavity is located in the part of the channel, thereby forming liquid communication.

6. The method according to claim 5, wherein, after the liquid sample is collected, a sealing element is used to seal the hole or the extension channel, thereby preventing the second chamber from being in fluid communication with the first chamber.

7 . The method according to claim 6 , wherein, when the second cavity is no longer in fluid communication with the first cavity, the tray is moved away from the first cavity, thereby driving the second cavity to move away from the first cavity.

8. The method of claim 7, wherein the second cavity is detached from the tray.

9. The method according to claim 8, wherein after the second cavity is separated from the tray, the opening of the second cavity is covered with a second cover to form a sealed second cavity.

10. The method according to any one of claims 1 to 9, wherein a first cover body is provided to cover the opening of the first cavity, and the sealing element is arranged on the cover body so that the cover body and the sealing element move in linkage.

11. The method according to claim 10, wherein, when the opening of the first cavity is closed with the cover, the cover body drives the sealing element to prevent the liquid from flowing between the first cavity and the second cavity.

12. The method of claim 10, wherein the cover body drives a sealing element to seal the hole or the extension channel between the first cavity and the second cavity.

13. The method according to claim 10, wherein the cover body drives the sealing element so that a portion of the sealing element enters into the extension channel.

14. The method according to claim 10, wherein the cover body further comprises a drainage element, and the drainage element is farther away from the cover body than the sealing element.

15. The method according to claim 10, wherein the cover body further comprises a liquid-repellent channel, and the liquid-repellent channel comprises a liquid inlet, and the position of the liquid inlet is farther away from the cover body than the sealing element; or, the liquid inlet enters the extension channel before the sealing element.

16. The method according to claim 15, wherein the projection area of the liquid inlet is located within the projection area of the sealing element.

17. The method according to claim 15, wherein part of the liquid forced by the sealing element enters the liquid-repellent channel through the liquid inlet and is thereby discharged out of the channel and/or the second chamber.

18. The method according to any one of claims 14 to 17, wherein the liquid-repellent channel comprises a liquid outlet, and the liquid outlet is in liquid communication with a receiving chamber.

19. The method according to claim 18, wherein the receiving chamber is located in a sealing element, a drainage element or a cover body.

20. The method according to claim 19, wherein, when the portion of the sealing element enters into the connecting channel, the receiving chamber is used to receive the liquid sample discharged by the sealing element entering into the connecting channel.

21. The method according to claim 19, wherein when the liquid-discharging element enters the second cavity, the portion of the sample discharged by the liquid-discharging element also enters the receiving cavity.

1. A detection device for detecting an analyte in a sample comprises: a first chamber for collecting a liquid sample; and a second chamber for collecting a liquid sample for confirmation of detection, wherein the first chamber has an opening for receiving the liquid sample, and the second chamber has an opening for receiving the liquid sample from the first chamber, wherein the device also includes a test element.

2. The device according to claim 1, wherein the device further comprises a tray structure, wherein the tray structure is detachably connected to the first cavity, wherein the second cavity is arranged on the tray, and the second cavity is detachably combined, assembled or connected to the first cavity through the tray.

3. The device according to claim 2, wherein the second chamber realizes fluid communication with the first chamber through a channel.

4. The device of claim 2, wherein the channel has a first opening and a second opening, the first opening being in fluid communication with the first chamber, and the second opening being in fluid communication with the second chamber.

5. The device according to claim 4, wherein the device further comprises a sealing element for sealing the connecting channel.

6. The device according to claim 5, wherein the sealing element for sealing the connecting channel can be sealed by entering the connecting channel through the first opening of the sealing channel or a part of the sealing element.

7. The device according to claim 5, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet and a liquid outlet, and the liquid inlet is located in the area below the sealing element.

8. The device according to claim 5, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet and a liquid outlet, and the projection area of the liquid inlet is located within the projection area of the sealing element.

9. The device according to claim 5, wherein the device further comprises a drainage element for draining part of the liquid in the second chamber, and the drainage element is connected to the sealing element.

10. The device according to claim 9, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet, and the liquid inlet is located on the liquid discharge element.

11. The device according to claim 10, wherein the liquid-repellent channel comprises a liquid outlet, the liquid outlet is in liquid communication with the receiving chamber, and the receiving chamber is used to store liquid discharged by the liquid-discharging element.

12. The device according to claim 11, wherein when the part of the sealing element enters into the channel, the receiving chamber is used to receive the liquid sample discharged by the sealing element entering into the connecting channel.

13. The device according to claim 11, wherein the receiving chamber is located in a sealing element or a drainage element.

14. The device according to claim 9, wherein the projection area of the drainage element is located within the vertical projection area of the sealing element.

15. The device of claim 14, wherein the transverse diameter of the drainage element is smaller than the transverse diameter of the sealing element.

16. The device according to claim 5, wherein the connecting channel is cylindrical and the sealing element is also cylindrical.

17. The device according to claim 4, wherein the device further comprises a first cover body for covering the opening of the first cavity, and the sealing element is arranged on the cover body, so that when the first cover body covers the opening of the first cavity, the sealing element seals the first opening of the connecting channel or part of the element enters the connecting channel along with the closing of the cover body.

18. The device according to claim 17, wherein the device further comprises a drainage element, wherein the drainage element is connected to the sealing element.

19. The device of claim 18, wherein the drainage element is further away from the first cover than the sealing element.

20. The device according to claim 19, wherein the sealing element is connected to the first cover body via a connecting rod.

21. The device according to claim 20, wherein the sealing element is detachably connected to the connecting rod.

22. The device according to claim 18, wherein the device further comprises a liquid-repelling channel, the liquid-repelling channel comprises a liquid inlet, and a projection area of the liquid inlet is located within a projection area of the sealing element.

23. The device according to claim 22, wherein the liquid inlet is farther away from the first cover body than the sealing element.

24. The device according to claim 23, wherein the liquid inlet is located on the liquid discharge element.

25. The device of claim 18, wherein the drainage element or a portion of the drainage element is located in the second chamber when the sealing element seals the passage.

26. The device according to claim 1, wherein the device further comprises a detection chamber, the detection chamber is fluidly connected to the first chamber, and the test element is located in the detection chamber.

27. The device according to claim 1, wherein the device further comprises a carrier, the carrier comprises a plurality of channels for accommodating test elements, and the carrier is located in the first cavity.

28. The device of claim 27, wherein the sample application area of the test element is located at the bottom of the first cavity.

1. A cavity for collecting a liquid sample, characterized in that the cavity comprises:

Side wall;

and an opening for receiving liquid, wherein the bottom has a hole for allowing the liquid sample entering the cavity to flow out of the cavity.

2. The cavity according to claim 1, characterized in that there is an area protruding into the cavity at the bottom of the cavity, and the protruding area and the side wall form a liquid sample collection area.

3. The chamber according to claim 2, characterized in that the sample collection area is configured to receive a test carrier.

4 . The chamber according to claim 3 , wherein the test carrier comprises a test element.

5. The cavity according to claim 2, characterized in that the raised area includes the hole.

6. The chamber according to claim 5, characterized in that the hole has an extended channel.

7. The cavity according to claim 6, characterized in that the channel extends into the cavity and/or extends out of the cavity.

8. The cavity according to claim 6, characterized in that the channel extends outside the cavity.

9. The cavity according to claim 5, characterized in that the raised area has a platform structure in the cavity, and the platform structure includes the hole.

10. The cavity according to claim 7 or 8, characterized in that the cavity further comprises an extended area at the bottom, and the length of the extended area exceeds or is equal to the length of the extended channel.

11. The cavity according to claim 6, characterized in that the position of the hole is higher than the bottom of the collection area, or, when collecting liquid, the liquid is allowed to first reach the collection area and then flow into the hole.

1. A cover body, characterized in that the cover body comprises a sealing element.

2. The cover body according to claim 1 is characterized in that the cover body is used to cover the opening of the cavity.

3. The cover body according to claim 1 is characterized in that the cover body further comprises a connecting rod structure, one end of the connecting rod is connected to the cover body, and the other end is connected to the sealing element.

4. The cover body according to claim 3 is characterized in that the sealing element is the end of a part of the connecting rod, or the sealing element and the connecting rod are an integral structure.

5. The cover according to claim 3, wherein the sealing element is made of elastic material.

6. The cover body according to claim 3, characterized in that the sealing element and the connecting rod are detachably connected.

7. The cover body according to claim 3 is characterized in that the sealing element and the connecting rod are plugged in and connected in a threaded or snap-fit manner.

8. The cover body according to claim 3, characterized in that the sealing element and the connecting rod are hollow structures.

9. The cover body according to claim 3, characterized in that the sealing element and the connector are injection molded in one step.

10. The cover according to claim 3, wherein the sealing element comprises a sealing ring.

11. The cover according to claim 10, characterized in that the sealing ring and the sealing element are made of the same material, or the sealing element containing the sealing ring is injection molded in one step.

1. A cover body, characterized in that the cover body comprises a sealing element and a liquid discharge element.

2. The cover body according to claim 1 is characterized in that the cover body is used to cover the opening of the cavity.

3. The cover body according to claim 1 is characterized in that the cover body also includes a connecting rod structure, one end of the connecting rod is connected to the cover body, and the other end is connected to the sealing element and the drainage element.

4. The cover body according to claim 3 is characterized in that the sealing element is the end of a part of the connecting rod, or the sealing element and the connecting rod are an integral structure.

5. The cover according to claim 3, wherein the sealing element is made of elastic material.

6. The cover body according to claim 3, characterized in that the sealing element is connected to the drainage element.

7. The cover body according to claim 6 is characterized in that the drainage element is farther away from the main body of the cover body than the sealing element.

8. The cover according to claim 7, characterized in that the vertical projection of the drainage element is located within or overlaps with the vertical projection area of the sealing element.

9. The cover body according to claim 7, characterized in that the transverse diameter of the drainage element is smaller than the transverse diameter of the sealing element.

10. The cover according to claim 7, wherein the drainage element is in a cone shape.

11. The cover according to claim 3, characterized in that one of the sealing element, the connecting rod and the drainage element comprises a hollow cavity, or the sealing element, the connecting rod and the drainage element are all hollow structures.

1. A cover body, characterized in that the cover body comprises a sealing element, a liquid discharge element and a receiving cavity.

2. The cover body according to claim 1 is characterized in that the cover body also includes a connecting rod structure, one end of the connecting rod is connected to the cover body, and the other end is connected to the sealing element and the drainage element.

3. The cover body according to claim 3 is characterized in that the sealing element is the end of a part of the connecting rod, or the sealing element and the connecting rod are an integral structure.

4. The cover body according to claim 3, characterized in that the sealing element is made of elastic material.

5. The cover body according to claim 3, characterized in that the sealing element is connected to the drainage element.

6. The cover body according to claim 6, characterized in that the drainage element is farther away from the main body of the cover body than the sealing element.

7. The cover body according to claim 1 is characterized in that one of the sealing element, the connecting rod, and the drainage element includes a hollow cavity, or the sealing element, the connecting rod, and the drainage element are multiple hollow structures, and the receiving cavity is a partial hollow cavity or a hollow structure.

8. The cover according to claim 7, wherein a transverse diameter of the drainage element is smaller than a transverse diameter of the sealing element.

9. The cover according to claim 7, characterized in that the drainage element is in a cone shape.

10. The cover body according to claim 1, wherein the receiving cavity is located in the connecting rod, the sealing element or the drainage element.

1. A cover body, characterized in that the cover body comprises a sealing element and a liquid-repelling channel, and the liquid-repelling channel comprises a liquid inlet and a liquid outlet.

2. The cover body according to claim 1 is characterized in that the cover body also includes a connecting rod structure, one end of the connecting rod is connected to the cover body, and the other end is connected to the sealing element.

3. The cover body according to claim 1 or 2, characterized in that the liquid inlet of the liquid-repellent channel is farther away from the main body of the cover body than the sealing element.

4. The cover body according to claim 3 is characterized in that the sealing element is connected to the drainage element.

5 . The cover body according to claim 3 , wherein the liquid inlet of the liquid-repellent channel is located on the liquid discharge element.

6. The cover body according to claim 3, characterized in that the sealing element comprises a sealing ring, and the liquid inlet of the liquid-repellent channel is farther away from the main body of the cover body than the sealing ring.

7. The cover body according to claim 3 is characterized in that the cover body further comprises a receiving cavity, wherein the liquid outlet of the liquid-repellent channel is in fluid communication with the receiving cavity.

8. The cover body according to claim 1 is characterized in that one of the sealing element, the connecting rod, and the drainage element includes a hollow cavity, or the sealing element, the connecting rod, and the drainage element are multiple hollow structures, and the liquid outlet of the hydrophobic channel is fluidically connected to the hollow cavity or the hollow structure.

9. The cover body according to claim 3, characterized in that the liquid outlet of the liquid-repellent channel is farther away from the main body of the cover body than the sealing element.

10. The cover according to any one of claims 1 to 9, characterized in that a vertical projection of the drainage element is within or overlaps a vertical projection area of the sealing element.

1. A device for collecting liquid samples, characterized in that it comprises a first cavity and a second cavity, wherein the bottom of the cavity has an area protruding into the cavity, the protruding area forms a space protruding relative to the first cavity, thereby forming a space concave relative to the bottom, and part of the second cavity is located in the concave area.

2. The sample collection device according to claim 1, wherein the first cavity comprises a hole, and the hole and the opening of the second cavity form a liquid flow state.

3. The sample collection device according to claim 1, further comprising a connecting channel, wherein the second cavity is formed by a detachable combination, bond or assembly with the connecting channel.

4. The sample collection device according to claim 3, wherein the opening of the second cavity comprises an external thread, the connecting channel comprises an internal thread, and the external thread of the second cavity and the internal thread of the connecting channel are combined, coupled or assembled by threads.

5. The sample collection device according to claim 3, wherein the hole has an extended channel, the extended section is a part of the connecting channel, and the extended channel is located in the recessed space.

6. The sample collection device according to claim 5, wherein the partially extended channel is located in the second cavity.

7. The sample collection device according to claim 6, wherein the outer diameter of the partially extended channel is equal to or smaller than the inner diameter of the opening of the second cavity.

8. The sample collection device according to claim 6, wherein the extension channel is inserted into the second cavity.

9. The sample collection device according to claim 2, further comprising a connecting channel, wherein the hole is a first opening of the connecting channel, the first opening is fluidically connected to the first cavity, and the second cavity is fluidically connected to the second opening of the connecting channel.

10. The sample collection device according to claim 1, further comprising a tray structure, wherein the second cavity is detachably disposed on the tray structure, and the tray structure is detachably combined with the first cavity.

1. A cavity for collecting a fluid sample, characterized in that the cavity comprises:

Side wall;

and an opening for receiving liquid, wherein the bottom has an opening for allowing a liquid sample entering the cavity to flow out of the cavity, wherein the device further comprises a detection cavity for placing a test element, and the detection cavity is in liquid communication with the cavity through a through hole.

2. According to the cavity of claim 1, the position of the opening is higher than the position of the through hole, or the opening is closer to the opening of the cavity than the through hole; or the through hole is closer to the bottom of the cavity than the opening.

3. According to the cavity of claim 1, when the cavity collects liquid samples, the liquid first enters the through hole and then enters the opening, or part of the liquid sample enters the through hole and part of the liquid sample enters the opening.

4. The cavity according to claim 1, wherein the opening comprises a channel extending outward from the bottom.

5 . The cavity according to claim 1 , wherein the bottom of the cavity has an area protruding into the cavity, and the protruding area and the side wall form a liquid sample collection area.

6 . The cavity according to claim 5 , wherein the collecting area comprises a bottom, and the opening is higher than the bottom position of the collecting area.

7. The cavity according to claim 6, wherein the bottom of the collecting area is a bottom area of a portion of the cavity.

8. The cavity according to claim 1, characterized in that the detection cavity comprises a test element.

9 . The cavity according to claim 8 , wherein the test element is located on a carrier, and the carrier is located in the detection cavity.

10. The chamber of claim 1, wherein the test element comprises a sample application area for contacting a liquid sample in the test volume.

1. A device for collecting liquid samples, characterized in that the device comprises: a first chamber and a second chamber for collecting liquid samples, the second chamber also comprising a detection chamber for initial detection connected to the second chamber fluid, wherein the bottom of the first chamber has an opening, and the opening is sealed by a sealing element.

2. The device according to claim 1 is characterized in that the first cavity and the second cavity are detachably combined, coupled or assembled.

3. The device according to claim 1 is characterized in that the sealing element is a pierceable sealing element.

4. The device according to claim 3, characterized in that the sealing element is one or more of plastic film, double-sided tape, single-sided tape, and aluminum foil.

5. The device according to claim 1, characterized in that the opening has a channel extending outward, and the channel includes a second opening in fluid communication with the second chamber.

6. The device according to claim 1 is characterized in that the device also includes a piercing element and/or another sealing element for piercing the sealing element.

7. The device according to claim 6 is characterized in that the device also has another sealing element, and the other sealing element is used to seal the opening after the puncturing element pierces the sealing element.

8. The device according to claim 7 is characterized in that the puncturing element and another sealing element are arranged on a first cover body, and the first cover body is used to cover the opening of the first cavity.

9. The device according to claim 8 is characterized in that the piercing element is away from the main body of the cover body relative to the other sealing element.

10. The device according to claim 8 is characterized in that the puncturing element and the other sealing element are arranged so that the puncturing element first punctures the sealing element of the sealing opening, then releases part of the liquid into the second chamber, and then the other sealing element seals the opening.

11. The device according to claim 5, characterized in that the device further comprises a second cover for sealing the second opening of the channel.

All patents and publications mentioned in the present specification indicate that these are public technologies in the field and can be used in the present invention. All patents and publications cited here are also listed in the references, just as each publication is specifically cited separately. The present invention described here can be implemented in the absence of any one or more elements, one or more restrictions, and such restrictions are not specifically stated here. For example, in each example here, the terms "comprising", "substantially consisting of..." and "consisting of..." can be replaced by the other two terms of one of the two. The so-called "one" here only means "one", but does not exclude that it only includes one, and can also mean that it includes more than two. The terms and expressions used here are descriptive and not limited by them. There is no intention to indicate that these terms and explanations described in this book exclude any equivalent features, but it can be known that any appropriate changes or modifications can be made within the scope of the present invention and the claims. It can be understood that the embodiments described in the present invention are some preferred embodiments and features, and any person skilled in the art can make some changes and variations based on the essence of the present invention, and these changes and variations are also considered to belong to the scope of the present invention and the scope limited by the independent claims and the appended claims.

Claims (25)

1. A device for collecting a liquid sample, characterized in that the device comprises a first chamber and a second chamber, wherein the first chamber comprises an opening for introducing the liquid sample, the first chamber is surrounded by a side wall and a bottom, the bottom of the first chamber is provided with a convex area, the convex area is positioned in the center of the whole bottom, the convex area is provided with an opening, and the device is provided with a section of connecting channel, the first opening of the connecting channel is communicated with the inside of the first chamber, and the second opening is communicated with the opening of the second chamber; forming a recess around the raised region inside the first cavity, the recess forming a liquid sample collection region; a thread structure is arranged on the opposite wall of the outer side of the connecting channel, which is close to the second opening, and a thread structure is arranged on the outer wall of the opening of the second cavity, and the thread structure on the wall form rotary fit, so that the second cavity and the first cavity form detachable fit through the connecting channel; meanwhile, the device also comprises a detection cavity which is in liquid communication with the first cavity through a through hole; the detection cavity comprises a test element, and the test element is arranged in a clamping groove of the test carrier; the sample application area of the test element is positioned at the area of the test carrier close to the bottom of the second cavity or close to the bottom of the detection cavity, and the water absorption area of the test element is positioned close to the other end of the detection cavity and close to one end of the opening of the first cavity;

The cover body is also provided, the center of the cover body is connected with a connecting rod, the tail end of the connecting rod is provided with a sealing element, and the sealing element is provided with a sealing ring; meanwhile, a liquid draining element is arranged below the sealing element, and the liquid draining element, the sealing element and the connecting rod are integrally formed; the length of the connecting rod, the sealing element and the liquid draining element is longer than the distance from the opening of the first cavity to the opening of the second cavity, so that the liquid draining element can enter the second cavity, and part of liquid sample in the second cavity is discharged; meanwhile, a liquid inlet of a lyophobic channel is arranged below the sealing element; the liquid inlet is positioned between the liquid discharging element and the sealing element; meanwhile, the sealing element, the liquid draining element and the connecting rod are hollow structures, and the inside of the sealing element, the liquid draining element and the connecting rod comprises a containing cavity for collecting redundant liquid samples;

the first opening of the connecting channel is located higher than the height of the through hole, and the position of the collecting area is lower than the position of the first opening of the connecting channel.

2. The device of claim 1, wherein the first and second chambers are removably combined, joined, or assembled.

3. The device of claim 1, wherein the bottom of the first chamber has an opening, the opening being sealed by a sealing element; the sealing element is a penetrable sealing element.

4. A device according to claim 3, wherein the sealing element is one or more of a plastic film, a double sided tape, a single sided tape, an aluminum foil.

5. The device of claim 1, wherein the opening in the bottom of the first chamber has an outwardly extending passage, said passage including a second opening in fluid communication with the second chamber.

6. The device of claim 1, further comprising a lancing element for lancing the sealing element.

7. The device of claim 6, further comprising another sealing element for sealing the opening in the bottom of the first chamber after the lancing element lances the sealing element.

8. The device of claim 7, wherein the piercing element and the further sealing element are disposed on a first cap for covering the opening of the first cavity.

9. The device of claim 8, wherein the piercing element is remote from the body of the cap relative to the other sealing element.

10. The device of claim 8, wherein the piercing element and the further sealing element are arranged such that the piercing element pierces the sealing element sealing the opening in the bottom of the first chamber, and then releases a portion of the liquid into the second chamber, and then the further sealing element seals the opening in the bottom of the first chamber.

11. The device of claim 5, further comprising a second cover for sealing the second opening of the passageway.

12. The device of claim 2, wherein the removable means is provided by a mating of the threaded formation of the first chamber and the threaded formation of the second chamber.

13. The device of claim 12, wherein the first lumen comprises external threads and the second lumen comprises internal threads.

14. The device of claim 6, further comprising a cap for covering the opening of the first chamber, wherein the piercing element of the piercing seal and/or the further seal is arranged in conjunction with the cap.

15. The device of claim 14, wherein the piercing element is remote from the body of the cap relative to the other sealing element.

16. The device of claim 15, wherein the piercing element and the further sealing element are arranged such that the piercing element pierces the sealing element sealing the opening, and then releases a portion of the liquid into the second chamber, and then allows the further sealing element to seal the opening.

17. A method of collecting and detecting a liquid sample, the method comprising:

detection using the device for collecting a liquid sample according to claim 1.

18. The method of claim 17, wherein after the first chamber collects the liquid, a piercing element is caused to pierce the sealing element, thereby releasing the liquid into the second chamber.

19. The method of claim 18, wherein the opening in the lancing element is sealed by a further sealing element.

20. The method of claim 19, wherein the liquid sample entering the detection chamber is subjected to a primary detection.

21. The method of claim 20, wherein the second confirmatory test is performed by disengaging the first chamber from the second chamber either before or after the first test is performed.

22. The method of claim 21, wherein the opening at the bottom of the first chamber has an outwardly extending channel, and wherein the opening of the channel is sealed with a cap after the second chamber is disengaged from the first chamber.

23. The method of claim 22, wherein a cap is provided covering the opening of the first chamber for receiving the liquid sample, the cap and the further sealing member and the lancing member being moved in tandem.

24. The method of claim 23, wherein said linkage is rotated.

25. The method of claim 24, wherein the cap is configured to release the liquid into the second chamber by allowing the piercing member to pierce the member sealing the liquid discharge opening during the closing of the opening of the first chamber for receiving the liquid sample; and then letting the further sealing element seal the drain opening.