CN110075032B - Xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and preparation method thereof - Google Patents
Xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and preparation method thereof Download PDFInfo
- Publication number
- CN110075032B CN110075032B CN201910441212.6A CN201910441212A CN110075032B CN 110075032 B CN110075032 B CN 110075032B CN 201910441212 A CN201910441212 A CN 201910441212A CN 110075032 B CN110075032 B CN 110075032B
- Authority
- CN
- China
- Prior art keywords
- parts
- xanthan gum
- sodium alginate
- oil
- water emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 title claims abstract description 88
- 239000000661 sodium alginate Substances 0.000 title claims abstract description 88
- 235000010413 sodium alginate Nutrition 0.000 title claims abstract description 88
- 229940005550 sodium alginate Drugs 0.000 title claims abstract description 88
- 239000000230 xanthan gum Substances 0.000 title claims abstract description 88
- 229920001285 xanthan gum Polymers 0.000 title claims abstract description 88
- 235000010493 xanthan gum Nutrition 0.000 title claims abstract description 88
- 229940082509 xanthan gum Drugs 0.000 title claims abstract description 88
- 239000007764 o/w emulsion Substances 0.000 title claims abstract description 56
- 239000002131 composite material Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 72
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 64
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims abstract description 48
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 48
- 229930003427 Vitamin E Natural products 0.000 claims abstract description 32
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 32
- 235000019165 vitamin E Nutrition 0.000 claims abstract description 32
- 229940046009 vitamin E Drugs 0.000 claims abstract description 32
- 239000011709 vitamin E Substances 0.000 claims abstract description 32
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 29
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 29
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 27
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 27
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 27
- 102000008186 Collagen Human genes 0.000 claims abstract description 26
- 108010035532 Collagen Proteins 0.000 claims abstract description 26
- 229920001436 collagen Polymers 0.000 claims abstract description 26
- 239000002994 raw material Substances 0.000 claims abstract description 26
- 241000209140 Triticum Species 0.000 claims abstract description 25
- 235000021307 Triticum Nutrition 0.000 claims abstract description 25
- 229940119217 chamomile extract Drugs 0.000 claims abstract description 25
- 235000020221 chamomile extract Nutrition 0.000 claims abstract description 25
- 235000011187 glycerol Nutrition 0.000 claims abstract description 25
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims abstract description 24
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 claims abstract description 24
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 24
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 24
- 239000008367 deionised water Substances 0.000 claims abstract description 24
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 24
- 229940031575 hydroxyethyl urea Drugs 0.000 claims abstract description 24
- 235000019437 butane-1,3-diol Nutrition 0.000 claims abstract description 22
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 20
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims abstract description 19
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims abstract description 19
- 239000003755 preservative agent Substances 0.000 claims abstract description 8
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 7
- 239000002245 particle Substances 0.000 claims abstract description 7
- 230000002335 preservative effect Effects 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 6
- 238000004945 emulsification Methods 0.000 claims abstract description 6
- 235000004866 D-panthenol Nutrition 0.000 claims abstract description 5
- 239000011703 D-panthenol Substances 0.000 claims abstract description 5
- 229960005150 glycerol Drugs 0.000 claims abstract description 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 38
- 238000003756 stirring Methods 0.000 claims description 35
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 29
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 26
- 239000004359 castor oil Substances 0.000 claims description 23
- 235000019438 castor oil Nutrition 0.000 claims description 23
- 229940082500 cetostearyl alcohol Drugs 0.000 claims description 23
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 23
- 229940119170 jojoba wax Drugs 0.000 claims description 23
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims description 23
- 239000003921 oil Substances 0.000 claims description 21
- LADGBHLMCUINGV-UHFFFAOYSA-N tricaprin Chemical compound CCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCC)COC(=O)CCCCCCCCC LADGBHLMCUINGV-UHFFFAOYSA-N 0.000 claims description 21
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 19
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 19
- 229960002216 methylparaben Drugs 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 11
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 4
- 239000006210 lotion Substances 0.000 claims description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 6
- BDOYKFSQFYNPKF-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical compound [Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O BDOYKFSQFYNPKF-UHFFFAOYSA-N 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 2
- MJOQJPYNENPSSS-XQHKEYJVSA-N [(3r,4s,5r,6s)-4,5,6-triacetyloxyoxan-3-yl] acetate Chemical compound CC(=O)O[C@@H]1CO[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O MJOQJPYNENPSSS-XQHKEYJVSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 239000000839 emulsion Substances 0.000 abstract description 58
- 108010022355 Fibroins Proteins 0.000 abstract description 22
- 229940074410 trehalose Drugs 0.000 abstract description 21
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 10
- 238000010438 heat treatment Methods 0.000 abstract description 9
- 238000000034 method Methods 0.000 abstract description 8
- 230000014759 maintenance of location Effects 0.000 abstract description 6
- 238000009826 distribution Methods 0.000 abstract description 4
- 230000003647 oxidation Effects 0.000 abstract description 4
- 238000007254 oxidation reaction Methods 0.000 abstract description 4
- 239000012071 phase Substances 0.000 description 27
- 235000019198 oils Nutrition 0.000 description 18
- LXAHHHIGZXPRKQ-UHFFFAOYSA-N 5-fluoro-2-methylpyridine Chemical compound CC1=CC=C(F)C=N1 LXAHHHIGZXPRKQ-UHFFFAOYSA-N 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 15
- 238000012360 testing method Methods 0.000 description 13
- 230000003020 moisturizing effect Effects 0.000 description 12
- 239000000203 mixture Substances 0.000 description 10
- 230000001804 emulsifying effect Effects 0.000 description 8
- 239000008346 aqueous phase Substances 0.000 description 7
- -1 free radical lipid Chemical class 0.000 description 7
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- 230000003078 antioxidant effect Effects 0.000 description 5
- 229960002446 octanoic acid Drugs 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- 239000003963 antioxidant agent Substances 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 229940075529 glyceryl stearate Drugs 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 229940088594 vitamin Drugs 0.000 description 3
- 229930003231 vitamin Natural products 0.000 description 3
- 235000013343 vitamin Nutrition 0.000 description 3
- 239000011782 vitamin Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 229960001631 carbomer Drugs 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 229930182478 glucoside Natural products 0.000 description 2
- 239000008169 grapeseed oil Substances 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 235000010981 methylcellulose Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 229960004063 propylene glycol Drugs 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 230000009759 skin aging Effects 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000002195 synergetic effect Effects 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 230000037303 wrinkles Effects 0.000 description 2
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 1
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 1
- 240000001548 Camellia japonica Species 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- BVTHRGZMQHOCOL-UHFFFAOYSA-N OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO Chemical compound OCC(O)(C1(NC(=O)NCNC(=O)NC2(CO)NC(=O)NC2=O)NC(=O)NC1=O)CO BVTHRGZMQHOCOL-UHFFFAOYSA-N 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000274 adsorptive effect Effects 0.000 description 1
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 229940059958 centella asiatica extract Drugs 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229960004106 citric acid Drugs 0.000 description 1
- 229940071160 cocoate Drugs 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 210000001339 epidermal cell Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 230000009707 neogenesis Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 239000010667 rosehip oil Substances 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229940083542 sodium Drugs 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000010257 thawing Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/645—Proteins of vegetable origin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Dispersion Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The invention provides a xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and a preparation method thereof, wherein the emulsion is prepared from the following raw materials: oil phase, emulsifier, alcohol, vitamin E, sodium hyaluronate, provitamin B5, hydrolyzed collagen, wheat protein, fibroin, chamomile extract, xanthan gum, sodium alginate, glycerol, 1, 3-butanediol, disodium ethylene diamine tetraacetate, trehalose, hydroxyethyl urea, deionized water and preservative. The preparation method is simple, heating is not needed in the emulsification process, and the required cost is low; the prepared emulsion has good stability, can effectively protect the activity of functional factors, has uniform particle size distribution, and has better rheological property, oxidation resistance and moisture retention performance.
Description
Technical Field
The invention relates to a xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and a preparation method thereof, belonging to the field of preparation of skin care emulsions.
Background
The increase of wrinkles, the aging of the skin, is the result of the reaction of free radicals with free radicals. After ultraviolet rays penetrate through the skin, excessive free radicals are generated, so that collagen and elastic fibers are loosened and broken, and the neogenesis of epidermal cells is slowed down; in addition, the cell nucleus is damaged by free radicals and cannot split into healthy cells, intercellular lipid is damaged, moisture of the skin cannot be maintained, and skin aging is caused over time. An important approach to skin aging is the use of antioxidant and moisturizing skin care products.
At present, the preparation of antioxidant and moisturizing emulsions has been reported in many ways. Vitamin E is a commonly used fat-soluble strong antioxidant, and can help resist peroxidation of free radical lipid, eliminate free radicals, promote regeneration of cell tissues and achieve the effect of delaying aging after entering a human body. However, vitamin E is very easily oxidized and easily loses efficacy if not properly treated. In the cosmetic industry, oil-in-water emulsions are often used as carriers to entrap the oil-in-water emulsions, and emulsions containing functional factors are prepared. Oil-in-water emulsions are susceptible to ionic strength, temperature, and the like, and are prone to delamination during long-term storage, and therefore there is a need to develop available ingredients and means to further improve the stability of emulsion products and to protect the effective activity of functional factors such as vitamin E.
Chinese patent document CN105496864A discloses a nutritional skin care emulsion containing oat peptide and a preparation method and application thereof; the nutritional skin care lotion comprises the following components: the component A comprises: oat peptide, methyl hydroxybenzoate, component B: water, magnesium aluminum silicate, and a component C: butanediol, glycerol, propylene glycol, sodium hyaluronate, xanthan gum, and the component D: squalane, ethylhexyl isopalmitate, dimethicone, butylated hydroxytoluene, propylparaben, cetostearyl alcohol, glyceryl stearate, PEG-100 stearate, sucrose stearate, cetostearyl glucoside, cetyl alcohol, vitamin E, camellia seeds, component E: hydrolyzing cod skin protein, radix Betae extract, carboxymethyl chitosan, antiseptic, and essence; and (3) evenly mixing the A, B, C components, adding the phase D, evenly mixing, adding the phase E, and evenly mixing to obtain the skin care emulsion. The emulsion has effects in nourishing skin, removing wrinkle, and resisting aging; but the used raw materials are more, the preparation method is complicated, the temperature required by the emulsification process is higher, and the cost is higher; more surfactant is added, and the skin irritation is larger. Chinese patent document CN108294979A discloses a moisturizing gel emulsion and a preparation method thereof, wherein the moisturizing gel emulsion comprises the following raw materials: rose hip oil, centella asiatica extract, grape seed oil, vitamin E, isopropyl myristate, PEG-7 olive oil ester, lecithin, alkyl glucoside, sodium alginate, 1, 2-propylene glycol, water, stearyl alcohol, ethyl cellulose, sodium stearyl hyaluronate, butanediol cocoate, methyl p-hydroxybenzoate, xanthan gum, carbomer and citric acid; the preparation method comprises preparing emulsion from oleum Rosae Davuricae, herba Centellae extract, grapeseed oil, vitamin E and PEG-7 oleum Olivarum, and adding hydrogel matrix xanthan gum, xanthan gum and carbomer. The invention has better moisturizing effect; but the used raw materials are more, the temperature required by the emulsification process is higher, the homogenization pressure is higher, the preparation process time is long, and the cost is higher; moreover, the addition of hydrogel can damage the emulsion, the emulsion has poor stability, and the efficacy of vitamin E and the like cannot be effectively protected.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and a preparation method thereof. The preparation method is simple, heating is not needed in the emulsification process, and the required cost is low; the prepared emulsion has good stability, can effectively protect the activity of functional factors, has uniform particle size distribution, and has better rheological property, oxidation resistance and moisture retention performance.
The technical scheme of the invention is as follows:
a xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
4-20 parts of an oil phase, 1-5 parts of an emulsifier, 0.1-1 part of alcohol, 0.1-2 parts of vitamin E, 0.02-1 part of sodium hyaluronate, 50.1-3 parts of provitamin B, 0.1-3 parts of hydrolyzed collagen, 0.1-3 parts of wheat protein, 0.1-3 parts of fibroin, 0.1-3 parts of chamomile extract, 0.1-2 parts of xanthan gum, 0.1-2 parts of sodium alginate, 2-15 parts of glycerol, 1-6 parts of 1, 3-butanediol, 0.05-0.15 part of disodium ethylenediamine tetraacetate, 0.2-5 parts of trehalose, 0.1-4 parts of hydroxyethyl urea, 40-90 parts of deionized water and 0.05-0.15 part of a preservative.
According to the invention, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is preferably prepared from the following raw materials in parts by mass:
6-14 parts of an oil phase, 1-3 parts of an emulsifier, 0.2-0.6 part of alcohol, 0.5-1.5 parts of vitamin E, 0.05-0.5 part of sodium hyaluronate, 50.3-2 parts of provitamin B, 0.3-2 parts of hydrolyzed collagen, 0.3-2 parts of wheat protein, 0.3-2 parts of fibroin, 0.3-1 part of chamomile extract, 0.25-1 part of xanthan gum, 0.25-1 part of sodium alginate, 5-10 parts of glycerol, 1-4 parts of 1, 3-butanediol, 0.05-0.15 part of disodium ethylenediamine tetraacetic acid, 0.5-3 part of trehalose, 0.3-2 parts of hydroxyethyl urea, 45-82 parts of deionized water and 0.05-0.15 part of a preservative.
According to the invention, the oil phase is preferably one or a mixture of more than two of caprylic/capric triglyceride, olive oil, jojoba oil or isopropyl myristate; preferably a mixture of caprylic/capric triglyceride and jojoba oil.
According to the invention, the emulsifier is one or a mixture of more than two of PEG-40 hydrogenated castor oil, glyceryl stearate or PEG-100 glyceryl stearate; preferably PEG-40 hydrogenated castor oil.
Preferably according to the invention, the alcohol is cetostearyl alcohol; the cetostearyl alcohol contains 50 to 70 weight percent of octadecanol and 20 to 35 weight percent of hexadecanol.
According to the invention, the granularity of the sodium alginate is preferably 50-200 meshes.
According to the invention, the preservative is preferably one of methyl paraben, phenoxyethanol, bis (hydroxymethyl) imidazolidinyl urea or imidazolidinyl urea; preferably, the preservative is methyl paraben.
According to the invention, the mass ratio of the xanthan gum to the sodium alginate is (2-4): 1; the addition amount of the xanthan gum and the sodium alginate is 0.24 wt% -1.1 wt% of the mass of the oil-in-water emulsion respectively.
Preferably, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
3-7 parts of caprylic/capric triglyceride, 3-7 parts of jojoba oil, 1-3 parts of PEG-40 hydrogenated castor oil, 0.2-0.6 part of cetostearyl alcohol, 0.5-1.5 parts of vitamin E, 0.05-0.5 part of sodium hyaluronate, 50.3-2 parts of provitamin B, 0.3-2 parts of hydrolyzed collagen, 0.3-2 parts of wheat protein, 0.3-2 parts of fibroin, 0.3-1 part of chamomile extract, 0.25-1 part of xanthan gum, 0.25-1 part of sodium alginate, 5-10 parts of glycerol, 1-4 parts of 1, 3-butanediol, 0.05-0.15 part of disodium ethylenediamine tetraacetic acid, 0.5-3 part of trehalose, 0.3-2 parts of hydroxyethyl urea, 45-82 parts of deionized water and 0.05-0.15 part of methylparaben.
The preferable technical scheme of the invention is as follows, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
4 parts of caprylic acid/capric acid triglyceride, 3 parts of jojoba oil, 1 part of PEG-40 hydrogenated castor oil, 0.4 part of cetostearyl alcohol, 1 part of vitamin E, 0.1 part of sodium hyaluronate, 50.5 parts of provitamin B, 0.5 part of hydrolyzed collagen, 0.5 part of wheat protein, 0.5 part of fibroin, 0.5 part of chamomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 2 parts of 1, 3-butanediol, 0.1 part of disodium ethylene diamine tetraacetate (EDTA disodium), 1 part of trehalose, 0.5 part of hydroxyethyl urea, 75.8 parts of deionized water and 0.1 part of methylparaben.
The other preferable technical scheme of the invention is as follows, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
4 parts of caprylic acid/capric acid triglyceride, 3 parts of jojoba oil, 1.5 parts of PEG-40 hydrogenated castor oil, 0.4 part of cetostearyl alcohol, 1 part of vitamin E, 0.1 part of sodium hyaluronate, 50.5 parts of provitamin B, 0.5 part of hydrolyzed collagen, 0.5 part of wheat protein, 0.5 part of fibroin, 0.5 part of chamomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 2 parts of 1, 3-butanediol, 0.1 part of disodium ethylene diamine tetraacetate (EDTA disodium), 1 part of trehalose, 0.5 part of hydroxyethyl urea, 75.3 parts of deionized water and 0.1 part of methylparaben.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors comprises the following steps:
(1) fully and uniformly mixing the oil phase, the emulsifier, the alcohol and the vitamin E to obtain an oil phase solution;
(2) dissolving sodium hyaluronate, provitamin B5, hydrolyzed collagen, wheat protein, fibroin, chamomile extract, xanthan gum, sodium alginate, glycerol, 1, 3-butanediol, disodium ethylene diamine tetraacetate, trehalose and hydroxyethyl urea in deionized water to obtain an aqueous phase solution;
(3) adding the oil phase solution into the water phase solution, and emulsifying under the condition of stirring at room temperature; and then adding a preservative, and stirring at room temperature for 1-2 hours to obtain the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors.
Preferably, in the step (3), the emulsifying time is 20-40 min; the stirring speed is 1000-6000 rpm.
The invention has the technical characteristics and beneficial effects that:
1. xanthan gum is a non-adsorptive water soluble macromolecule, and can be used as thickener and stabilizer; since aqueous xanthan gum is a pseudoplastic fluid, the addition of xanthan gum according to the present invention can impart good shear thinning properties to the emulsion. Sodium alginate is a natural polysaccharide substance, is not only a common cosmetic thickener and stabilizer, but also has good air permeability and moisture absorption, moisture retention and bacteriostasis functions. According to the invention, the xanthan gum and the sodium alginate are added into the emulsion, and the two exert synergistic effects, so that an interface layer can be formed on the surface of the O/W liquid drop, and the strength of the interface layer is improved, thus the stability of the emulsion can be enhanced, and the activity of functional factors such as vitamin E and the like can be effectively protected; the emulsion has good rheological property, and is beneficial to skin care application of the emulsion; the moisture retention and antibacterial property of the emulsion can be further improved, the use of expensive moisture retention functional factors and preservatives is reduced, the cost is reduced, and the safety of the product is improved.
2. The emulsifier preferably used in the invention is PEG-40 hydrogenated castor oil, has low irritation and good solubilization, and can realize the dispersion of functional factors such as vitamin E in water to form an oil-in-water emulsion. Meanwhile, the xanthan gum and the sodium alginate which are used have synergistic effect, a polymer interface layer is formed on the surface of the O/W liquid drop, the strength of the oil-water interface layer is improved, the emulsion can effectively entrap functional factor components such as vitamin E for a long time, the oxidation consumption of the vitamin E and the like in the storage process is reduced, and the emulsion has a better antioxidant effect in the use process. In the invention, disodium EDTA is also added as a chelating agent, so that the chelating effect of sodium alginate and metal ions in the emulsion can be avoided, and the stability of the emulsion is improved. The sodium hyaluronate and the sodium alginate used in the invention have good film forming property, and can form a uniform and breathable moisturizing layer on the surface of skin, and a large amount of hydroxyl groups on the molecules can effectively combine with water molecules, thereby reducing the loss of water. In addition, the selected jojoba oil has good oxidation resistance and excellent permeability, can permeate into the skin, directly supplements nutrients required by cell metabolism, and enhances the elasticity and moisturizing capability of the skin.
3. The preparation method is simple, the emulsification process does not need heating, the operation process is easy to control, and the cost is lower. The components in the emulsion do not play roles independently but influence and interact with each other, so that the obtained emulsion has uniform particle size distribution and good stability, can effectively protect the activity of functional factors, and has better rheological property and antioxidant moisturizing property.
Drawings
Fig. 1 is an optical microscope photograph of the oil-in-water emulsion prepared in example 3.
FIG. 2 is a plot of viscosity versus shear rate for the oil-in-water emulsion prepared in example 3.
Fig. 3 is a photograph comparing the oil-in-water emulsion prepared in example 3 without freezing and after frozen storage at-18 ℃ and thawing.
Detailed Description
The technical solution of the present invention is further described with reference to the following specific embodiments.
The test methods described in the examples are conventional methods unless otherwise specified; the reagents and starting materials used are all commercially available unless otherwise specified.
In the examples, jojoba oil is available from Anpin chemical Co., Ltd, Guangzhou; PEG-40 hydrogenated Castor oil, available from Shandong Yousio chemical science and technology Co., Ltd; sodium hyaluronate, available from Shandong Furuida; hydrolyzed collagen, wheat protein, fibroin, chamomile extract, available from lazhou camomile biochemicals ltd; sodium alginate, available from Qingdao Mingyue algae, viscosity of 500cps, and particle size of 100 mesh; cetostearyl alcohol, available from Guangzhou ear Xin chemical Co.
Example 1
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
the feed comprises, by weight, 4g of caprylic/capric triglyceride, 3g of jojoba oil, 1g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 1g of vitamin E, 0.1g of sodium hyaluronate, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin, 0.5g of chamomile extract, 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of disodium ethylenediaminetetraacetate (EDTA disodium), 1g of trehalose, 0.5g of hydroxyethyl urea, 75.8g of deionized water and 0.1g of methylparaben.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors comprises the following steps:
dissolving 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of EDTA disodium, 0.1g of sodium hyaluronate, 1g of trehalose, 0.5g of hydroxyethyl urea, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin and 0.5g of chamomile extract in 75.8g of deionized water, and stirring for 2 hours to obtain an aqueous phase solution;
mixing 1g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil and 1g of vitamin E, and heating and stirring at 50 ℃ to obtain a uniform oil phase solution;
slowly injecting the oil phase into the water phase under the condition of stirring, and stirring and emulsifying at the room temperature of 3000rpm for 30 minutes; and finally, adding 0.1g of methyl paraben, and stirring at room temperature of 1000rpm for 2 hours to obtain the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors.
Example 2
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
caprylic acid/capric acid triglyceride 4g, jojoba oil 3g, PEG-40 hydrogenated castor oil 1g, cetostearyl alcohol 0.4g, vitamin E1 g, sodium hyaluronate 0.1g, provitamin B50.5 g, hydrolyzed collagen 0.5g, wheat protein 0.5g, fibroin 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.25g, glycerol 6g, 1, 3-butanediol 2g, disodium ethylenediaminetetraacetate (EDTA disodium) 0.1g, trehalose 1g, hydroxyethyl urea 0.5g, deionized water 76.05g, and nipagin methyl ester 0.1 g.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors comprises the following steps:
dissolving 1g of xanthan gum, 0.25g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of EDTA disodium, 0.1g of sodium hyaluronate, 1g of trehalose, 0.5g of hydroxyethyl urea, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin and 0.5g of chamomile extract in 76.05g of deionized water, and stirring for 2 hours to obtain an aqueous phase solution;
mixing 1g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil and 1g of vitamin E, and heating and stirring at 50 ℃ to obtain a uniform oil phase solution;
slowly injecting the oil phase into the water phase under the condition of stirring, and stirring and emulsifying at the room temperature of 3000rpm for 30 minutes; and finally, adding 0.1g of methyl paraben, and stirring at 1000rpm for 2 hours at room temperature to obtain the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors.
Example 3
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
caprylic acid/capric acid triglyceride 4g, jojoba oil 3g, PEG-40 hydrogenated castor oil 1.5g, cetostearyl alcohol 0.4g, vitamin E1 g, sodium hyaluronate 0.1g, provitamin B50.5 g, hydrolyzed collagen 0.5g, wheat protein 0.5g, fibroin 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerol 6g, 1, 3-butanediol 2g, disodium ethylenediaminetetraacetate (EDTA disodium) 0.1g, trehalose 1g, hydroxyethyl urea 0.5g, deionized water 75.3g, and nipagin methyl ester 0.1 g.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors comprises the following steps:
dissolving 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of EDTA disodium, 0.1g of sodium hyaluronate, 1g of trehalose, 0.5g of hydroxyethyl urea, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin and 0.5g of chamomile extract in 75.3g of deionized water, and stirring for 2 hours to obtain an aqueous phase solution;
mixing 1.5g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil and 1g of vitamin E, and heating and stirring at 50 ℃ to obtain a uniform oil phase solution;
slowly injecting the oil phase into the water phase under the condition of stirring, and stirring and emulsifying at the room temperature of 3000rpm for 30 minutes; and finally, adding 0.1g of methyl paraben, and stirring at 1000rpm for 2 hours at room temperature to obtain the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors.
FIG. 1 is an optical microscope photograph of an oil-in-water emulsion prepared in this example; as can be seen from the figure, the obtained emulsion had a uniform particle size distribution and a particle size of 5 μm.
FIG. 2 is a graph of viscosity versus shear rate for the oil-in-water emulsion prepared in this example; as can be seen, the viscosity of the emulsion gradually decreased with increasing shear rate, indicating that the emulsion produced had good shear-thinning properties.
FIG. 3 is a comparative photograph of an oil-in-water emulsion prepared in this example, unfrozen and frozen at-18 ℃ and then thawed; as can be seen from the figure, although the emulsion is frozen and solidified after being frozen at-18 ℃, no delamination phenomenon appears after the emulsion is restored to the room temperature, the emulsion is still uniform and has good fluidity, and the emulsion is not delaminated after repeated tests.
Example 4
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
the feed comprises, by weight, 4g of caprylic/capric triglyceride, 3g of jojoba oil, 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 1g of vitamin E, 0.1g of sodium hyaluronate, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin, 0.5g of chamomile extract, 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of disodium ethylenediaminetetraacetate (EDTA disodium), 1g of trehalose, 0.5g of hydroxyethyl urea, 74.8g of deionized water and 0.1g of methylparaben.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors comprises the following steps:
dissolving 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of EDTA disodium, 0.1g of sodium hyaluronate, 1g of trehalose, 0.5g of hydroxyethyl urea, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin and 0.5g of chamomile extract in 74.8g of deionized water, and stirring for 2 hours to obtain an aqueous phase solution;
mixing 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil and 1g of vitamin E, and heating and stirring at 50 ℃ to obtain a uniform oil phase solution;
slowly injecting the oil phase into the water phase under the condition of stirring, and stirring and emulsifying at the room temperature of 3000rpm for 30 minutes; and finally, adding 0.1g of methyl paraben, and stirring at 1000rpm for 2 hours at room temperature to obtain the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors.
Example 5
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
the feed comprises, by weight, 4g of caprylic/capric triglyceride, 3g of jojoba oil, 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 1g of vitamin E, 0.1g of sodium hyaluronate, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin, 0.5g of chamomile extract, 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of disodium ethylenediaminetetraacetate (EDTA disodium), 1g of trehalose, 0.5g of hydroxyethyl urea, 74.8g of deionized water and 0.1g of methylparaben.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors comprises the following steps:
dissolving 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of EDTA disodium, 0.1g of sodium hyaluronate, 1g of trehalose, 0.5g of hydroxyethyl urea, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin and 0.5g of chamomile extract in 74.8g of deionized water, and stirring for 2 hours to obtain an aqueous phase solution;
mixing 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil and 1g of vitamin E, and heating and stirring at 50 ℃ to obtain a uniform oil phase solution;
slowly injecting the oil phase into the water phase under the condition of stirring, and stirring and emulsifying for 30 minutes at the room temperature of 4000 rpm; and finally, adding 0.1g of methyl paraben, and stirring at 1000rpm for 2 hours at room temperature to obtain the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors.
Example 6
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
the feed comprises, by weight, 4g of caprylic/capric triglyceride, 3g of jojoba oil, 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 1g of vitamin E, 0.1g of sodium hyaluronate, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin, 0.5g of chamomile extract, 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of disodium ethylenediaminetetraacetate (EDTA disodium), 1g of trehalose, 0.5g of hydroxyethyl urea, 74.8g of deionized water and 0.1g of methylparaben.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors comprises the following steps:
dissolving 1g of xanthan gum, 0.5g of sodium alginate, 6g of glycerol, 2g of 1, 3-butanediol, 0.1g of EDTA disodium, 0.1g of sodium hyaluronate, 1g of trehalose, 0.5g of hydroxyethyl urea, 50.5 g of provitamin B, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of fibroin and 0.5g of chamomile extract in 74.8g of deionized water, and stirring for 2 hours to obtain an aqueous phase solution;
mixing 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil and 1g of vitamin E, and heating and stirring at 50 ℃ to obtain a uniform oil phase solution;
slowly injecting the oil phase into the water phase under the condition of stirring, and stirring and emulsifying at 6000rpm at room temperature for 30 minutes; and finally, adding 0.1g of methyl paraben, and stirring at 1000rpm for 2 hours at room temperature to obtain the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors.
Example 7
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
caprylic acid/capric acid triglyceride 3g, jojoba oil 5g, PEG-40 hydrogenated castor oil 3g, cetostearyl alcohol 0.2g, vitamin E0.5 g, sodium hyaluronate 0.05g, provitamin B50.3 g, hydrolyzed collagen 0.3g, wheat protein 0.3g, fibroin 0.3g, chamomile extract 0.3g, xanthan gum 0.25g, sodium alginate 1g, glycerol 5g, 1, 3-butanediol 1g, disodium ethylenediaminetetraacetate (EDTA disodium) 0.1g, trehalose 1g, hydroxyethyl urea 0.5g, deionized water 76.9g, and nipagin methyl ester 0.1 g.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors is described in example 1.
Example 8
A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is prepared from the following raw materials in parts by mass:
7g of caprylic/capric triglyceride, 7g of jojoba oil, 3g of PEG-40 hydrogenated castor oil, 0.6g of cetostearyl alcohol, 1.5g of vitamin E, 0.5g of sodium hyaluronate, 2g of provitamin B52 g, 2g of hydrolyzed collagen, 2g of wheat protein, 2g of fibroin, 2g of chamomile extract, 1g of xanthan gum, 1g of sodium alginate, 10g of glycerol, 4g of 1, 3-butanediol, 0.1g of disodium ethylenediaminetetraacetate (disodium EDTA), 3g of trehalose, 2g of hydroxyethyl urea, 48.3g of deionized water and 0.1g of methylparaben.
The preparation method of the xanthan gum/sodium alginate composite oil-in-water emulsion rich in the functional factors is described in example 1.
Comparative example 1
An oil-in-water emulsion having the composition in parts by mass as described in example 1, except that: no xanthan gum is added; other raw materials and components were the same as in example 1.
The preparation process was identical to example 1.
Comparative example 2
An oil-in-water emulsion having the composition in parts by mass as described in example 1, except that: the adding amount of xanthan gum is 0.1g, and the adding amount of sodium alginate is 0.1 g; other raw materials and components were the same as in example 1.
The preparation process was identical to example 1.
Comparative example 3
An oil-in-water emulsion having the composition in parts by mass as described in example 1, except that: replacing xanthan gum with methylcellulose, wherein the addition amount is 0.5 g; other raw materials and components were the same as in example 1.
The preparation process was identical to example 1.
Comparative example 4
An oil-in-water emulsion having the composition in parts by mass as described in example 1, except that: EDTA disodium is not added; other raw materials and components were the same as in example 1.
The preparation process was identical to example 1.
Comparative example 5
An oil-in-water emulsion having the composition in parts by mass as described in example 3, except that: sodium alginate is not added; other raw materials and components were the same as in example 3.
The preparation process was identical to example 3.
Comparative example 6
An oil-in-water emulsion having the composition in parts by mass as described in example 3, except that: the adding amount of xanthan gum is 0.5g, and the adding amount of sodium alginate is 0.1 g; other raw materials and components were the same as in example 3.
The preparation process was identical to example 3.
Comparative example 7
An oil-in-water emulsion having the composition in parts by mass as described in example 1, except that: the adding amount of sodium alginate is 0.1 g; other raw materials and components were the same as in example 3.
The preparation process was identical to example 3.
Test example 1
The oil-in-water emulsions prepared in example 1 and comparative examples 1 to 4 were tested for cold, heat and centrifugal stability according to the national standard GB/T29665-.
The test results are shown in table 1 below, and it can be seen from table 1 that the addition of xanthan gum and the proportional relationship between xanthan gum and sodium alginate have an important effect on the stability of the emulsion. When the mass of xanthan gum and sodium alginate are relatively small, the prepared emulsion is not delaminated after centrifugation and at low temperature, but the heat resistance stability is relatively poor. The emulsion without the disodium EDTA is placed at room temperature, layering occurs in a short time, and the emulsion is poor in cold resistance, heat resistance and centrifugal stability, so that the disodium EDTA is used as a chelating agent, the chelating effect of sodium alginate and metal ions in the emulsion can be avoided, and the stability of the emulsion is improved; the xanthan gum is replaced by methyl cellulose, and the cold resistance and the heat resistance of the obtained emulsion are poor, which shows the importance of the specific xanthan gum of the invention on the stability.
TABLE 1 Cold, Heat and centrifugal stability test data
| Name (R) | Low temperature stability (-4 ℃ C.) | High temperature stability (50 ℃ C.) | Centrifugal stability (2000rpm 30min) |
| Example 1 | Not delaminating | Not delaminating | Not delaminating |
| Comparative example 1 | Not delaminating | Layering | Not delaminating |
| Comparative example 2 | Not delaminating | Layering | Not delaminating |
| Comparative example 3 | Layering | Layering | Not delaminating |
| Comparative example 4 | Layering | Layering | Layering |
Test example 2
The moisturizing performance of the emulsions obtained in comparative examples 5 to 7 and example 3 and the commercial emulsions obtained therefrom was tested by selecting 10 persons with the back of the hand as the test area. The instrument selected for testing the moisture content of the skin is a digital skin moisture detection pen, and no water exists on the surface of the skin during testing. The left hand of the tester is coated with the emulsion, and the right hand is not coated with the emulsion; after the tester washes hands for 1min, the moisture content is tested and used as the skin moisture content before testing, then the left hand is smeared with the emulsion, and the skin moisture content of the back of the left hand and the back of the right hand is tested after 4 hours. The skin moisture content was tested at three different locations each time, the test results are expressed as a percentage and the results of ten people are averaged.
The test results are shown in table 2, from which it is seen that the sodium alginate added in example 3 was 0.5% by weight, and that the water content of the left-hand skin, to which the emulsion was applied after 4 hours, was significantly higher than the water content of the right-hand skin, to which no emulsion was applied, and also higher than the water content of the test skin area, to which the commercial emulsion was applied; the skin moisture content of the emulsions obtained in comparative examples 5 to 7 after 4 hours was significantly lower than the test results of example 3. The moisturizing effect of the emulsion is influenced by the addition of the sodium alginate and the ratio of the addition amount of the sodium alginate to the xanthan gum, and the moisturizing performance of the emulsion is better due to a certain amount of the sodium alginate; meanwhile, when the proportion of the xanthan gum is larger, the emulsion has larger viscosity, the moisture is not easy to lose, and the emulsion has better moisturizing effect.
TABLE 2 moisture retention test data
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910441212.6A CN110075032B (en) | 2019-05-24 | 2019-05-24 | Xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910441212.6A CN110075032B (en) | 2019-05-24 | 2019-05-24 | Xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110075032A CN110075032A (en) | 2019-08-02 |
| CN110075032B true CN110075032B (en) | 2021-12-10 |
Family
ID=67421842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910441212.6A Expired - Fee Related CN110075032B (en) | 2019-05-24 | 2019-05-24 | Xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110075032B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110547455A (en) * | 2019-09-02 | 2019-12-10 | 嘉必优生物技术（武汉）股份有限公司 | Microcapsule containing sialic acid and carotenoid and preparation method and application thereof |
| CN111603395B (en) * | 2020-05-27 | 2022-04-08 | 山东大学 | Whitening and moisturizing emulsion containing lamellar liquid crystal and preparation method thereof |
| CN111743848A (en) * | 2020-06-28 | 2020-10-09 | 西安文理学院 | A kind of anti-aging facial mask containing deer antler and preparation method thereof |
| CN113144220B (en) * | 2021-04-30 | 2022-11-08 | 中国药科大学 | Beta-cyclodextrin inclusion compound, gel preparation, preparation method and application thereof |
| CN116270319A (en) * | 2023-02-28 | 2023-06-23 | 深圳大学 | A kind of emulsion containing astaxanthin and preparation method thereof |
Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2850017A1 (en) * | 2003-01-17 | 2004-07-23 | Rocher Yves Biolog Vegetale | Cosmetic composition in foam form comprises a gas-expanded oil-in-water emulsion containing a sugar derivative and a fatty acid as emulsifiers |
| DE10252757B4 (en) * | 2002-11-13 | 2004-09-23 | Beiersdorf Ag | Cosmetic and / or dermatological preparation in the form of an O / W emulsion and its use |
| US7563435B2 (en) * | 2002-10-28 | 2009-07-21 | Mmp, Inc. | Transparent lip treatment gel |
| CN101745329A (en) * | 2008-12-01 | 2010-06-23 | 赢创德固赛(中国)投资有限公司 | Method for preparing stable oil-in-water emulsion with high oil phase content and the emulsion prepared and the application thereof |
| CN101985587A (en) * | 2010-11-01 | 2011-03-16 | 自贡市轻工业设计研究院有限责任公司 | Composite salt-resistant thickening agent, and preparation method and application thereof |
| FR2983065A1 (en) * | 2011-11-25 | 2013-05-31 | Oreal | TINTED EMULSION |
| CN103142438A (en) * | 2013-03-21 | 2013-06-12 | 上海滇虹药业有限公司 | Oil-in-water emulsifiable paste and preparation method for same |
| CN107582492A (en) * | 2017-10-20 | 2018-01-16 | 新疆于田瑰觅生物科技股份有限公司 | Rose amino acid face cream, emulsion |
| CN108685758A (en) * | 2018-07-05 | 2018-10-23 | 青岛明月爱熙化妆品有限公司 | Moisturizing emulsion and preparation method thereof containing fucoidin |
| CN109568178A (en) * | 2017-09-29 | 2019-04-05 | 山西远扬医药科技有限公司 | A kind of nanometer of micro emulsion composition and its nano micro-emulsification cosmetic of preparation |
-
2019
- 2019-05-24 CN CN201910441212.6A patent/CN110075032B/en not_active Expired - Fee Related
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7563435B2 (en) * | 2002-10-28 | 2009-07-21 | Mmp, Inc. | Transparent lip treatment gel |
| DE10252757B4 (en) * | 2002-11-13 | 2004-09-23 | Beiersdorf Ag | Cosmetic and / or dermatological preparation in the form of an O / W emulsion and its use |
| FR2850017A1 (en) * | 2003-01-17 | 2004-07-23 | Rocher Yves Biolog Vegetale | Cosmetic composition in foam form comprises a gas-expanded oil-in-water emulsion containing a sugar derivative and a fatty acid as emulsifiers |
| CN101745329A (en) * | 2008-12-01 | 2010-06-23 | 赢创德固赛(中国)投资有限公司 | Method for preparing stable oil-in-water emulsion with high oil phase content and the emulsion prepared and the application thereof |
| CN101985587A (en) * | 2010-11-01 | 2011-03-16 | 自贡市轻工业设计研究院有限责任公司 | Composite salt-resistant thickening agent, and preparation method and application thereof |
| FR2983065A1 (en) * | 2011-11-25 | 2013-05-31 | Oreal | TINTED EMULSION |
| CN103142438A (en) * | 2013-03-21 | 2013-06-12 | 上海滇虹药业有限公司 | Oil-in-water emulsifiable paste and preparation method for same |
| CN109568178A (en) * | 2017-09-29 | 2019-04-05 | 山西远扬医药科技有限公司 | A kind of nanometer of micro emulsion composition and its nano micro-emulsification cosmetic of preparation |
| CN107582492A (en) * | 2017-10-20 | 2018-01-16 | 新疆于田瑰觅生物科技股份有限公司 | Rose amino acid face cream, emulsion |
| CN108685758A (en) * | 2018-07-05 | 2018-10-23 | 青岛明月爱熙化妆品有限公司 | Moisturizing emulsion and preparation method thereof containing fucoidin |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110075032A (en) | 2019-08-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN110075032B (en) | Xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and preparation method thereof | |
| US12194134B2 (en) | Two-dosage-form essence and preparation method thereof | |
| CN109157453B (en) | Skin-friendly sustained-release composition and cosmetic thereof | |
| CN108969446B (en) | Infant anti-chap skin care composition for enhancing skin barrier function and preparation method thereof | |
| CN107397714A (en) | With anti-blue light contamination and the elite breast of desalination microgroove effect and its preparation and application | |
| WO2015135313A1 (en) | Borojo skin care product and use thereof for natural moisturizing, anti-ageing, anti-uv, anti-anaphylaxis and whitening | |
| CN103393581A (en) | Natural anti-wrinkling anti-aging skin care composition and application thereof in cosmetic | |
| CN111166683A (en) | Fullerene anti-aging antioxidant beauty and skin care cosmetic and preparation method thereof | |
| CN109453043A (en) | Nano emulsion with good stability | |
| CN115607476B (en) | Composition with moisturizing and antioxidation effects and application thereof | |
| CN110179730B (en) | Repair cream | |
| CN113893203A (en) | Face cream composition containing anti-aging liposome and preparation method and application thereof | |
| CN113368022A (en) | Cream with moisturizing and skin brightening effects and preparation method thereof | |
| CN113995693B (en) | Essence composition of liposome with anti-inflammatory effect, and preparation method and application thereof | |
| KR100904370B1 (en) | Cosmetic composition containing nanoliposomes | |
| CN114642610A (en) | Moisturizing composition and preparation method and application thereof | |
| CN108113924A (en) | A kind of composite plant Shu Min agent and preparation method and application | |
| CN118319829A (en) | Skin care composition containing lactobacillus/algae extract fermentation product and preparation method and application thereof | |
| CN115778870B (en) | Anti-wrinkle anti-aging composition, and preparation method and application thereof | |
| EP3989928A1 (en) | Use of a hydro-alcoholic extract of evening primrose for hydrating skin and increasing barrier function | |
| CN117815095A (en) | Composition with relieving and repairing effects and preparation method thereof | |
| CN117357423A (en) | Anti-wrinkle eye cream and preparation method thereof | |
| KR102542315B1 (en) | Cosmetic Uses of Strawberry Fruit Extract | |
| CN110368325A (en) | A kind of anti-wrinkle composition and its preparation method and application | |
| CN109223696A (en) | A kind of disposable sleep mask and preparation method thereof with layer structure |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211210 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |