CN110075032A - A kind of compound oil-in-water emulsion of xanthan gum/sodium alginate and preparation method thereof rich in function factor - Google Patents

Abstract

The invention provides a xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and a preparation method thereof. The emulsion comprises the following raw materials: oil phase, emulsifier, alcohol, vitamin E, sodium hyaluronate , provitamin B5, hydrolyzed collagen, wheat protein, silk protein, chamomile extract, xanthan gum, sodium alginate, glycerin, 1,3-butanediol, disodium edetate, trehalose, hydroxyethyl base urea, deionized water and preservatives. The preparation method of the invention is simple, no heating is required in the emulsification process, and the required cost is low; the prepared emulsion has good stability, can effectively protect the activity of functional factors, has uniform particle size distribution, and has good rheological properties and anti-oxidation , Moisturizing performance.

Description

A kind of xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and its Preparation

technical field

The invention relates to a xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and a preparation method thereof, belonging to the field of preparation of skin care emulsions.

Background technique

The increase of wrinkles and the aging of the skin are the result of free radicals reacting with free radicals. After ultraviolet rays penetrate the skin, excessive free radicals will be generated, which will cause relaxation and breakage of collagen and elastic fibers, and slow down the regeneration of epidermal cells; and the nucleus will not be able to divide healthy cells due to damage by free radicals, and the lipids between cells will also be damaged. Damaged, unable to maintain the moisture of the skin, causing skin aging over time. An important way for the skin to resist aging is to use anti-oxidant and moisturizing skin care products.

Nowadays, the preparation of antioxidant and moisturizing emulsions has been widely reported. Vitamin E is a commonly used fat-soluble strong antioxidant. After entering the human body, it can help fight free radical lipid peroxidation, eliminate free radicals, promote cell tissue regeneration, and achieve the effect of delaying aging. However, vitamin E is easily oxidized, and if it is not handled properly, it will easily lose its efficacy. In the cosmetics industry, oil-in-water emulsions are usually used as carriers to entrap them to prepare emulsions containing functional factors. Oil-in-water emulsions are easily affected by factors such as ionic strength and temperature, and are prone to stratification during long-term storage. Therefore, it is necessary to develop available components and methods to further improve the stability of emulsion products and protect vitamin E and other functions. effective activity of the factor.

Chinese patent document CN105496864A discloses a nutritional skin care emulsion containing oat peptide and its preparation method and application; the composition of the nutritional skin care emulsion is: A component: oat peptide, methylparaben, B component: water, silicon Aluminum Magnesium Acid, Component C: Butylene Glycol, Glycerin, Propylene Glycol, Sodium Hyaluronate, Xanthan Gum, Component D: Squalane, Ethylhexyl Isopalmitate, Dimethicone, Butyl Hydroxytoluene, Propylparaben, Cetearyl Alcohol, Glyceryl Stearate, PEG-100 Stearate, Sucrose Stearate, Cetearyl Glucoside, Cetyl Alcohol, Vitamin E, Camellia Seed, component E: hydrolyzed cod skin protein, beet root extract, carboxymethyl chitosan, preservatives, essence; mix components A, B, and C evenly, add phase D and mix well, then add Phase E is evenly mixed to prepare a skin care emulsion. The emulsion has the effects of nourishing the skin, anti-wrinkle and anti-aging; however, it uses many raw materials, the preparation method is cumbersome, the temperature required for the emulsification process is high, and the cost is high; the addition of many surfactants is relatively irritating to the skin. Chinese patent document CN108294979A discloses a moisturizing gel emulsion and a preparation method thereof. The raw materials of the moisturizing gel emulsion include: rosehip oil, centella asiatica extract, grape seed oil, vitamin E, isopropyl myristate, PEG-7 Olive Oil Ester, Lecithin, Alkyl Glucoside, Sodium Alginate, 1,2-Propanediol, Water, Stearyl Alcohol, Ethyl Cellulose, Sodium Stearyl Hyaluronate, Butylene Glycol Cocoate Esters, methyl p-hydroxybenzoate, xanthan gum, xanthan gum, carbomer, citric acid; its preparation method is to first mix rosehip oil, centella asiatica extract, grape seed oil, vitamin E and PEG-7 The olive oil ester is made into an emulsion, and then the hydrogel matrix xanthan gum, xanthan gum and carbomer are added. The invention has better moisturizing effect; but more raw materials are used, the temperature required for the emulsification process is higher, the homogenization pressure is larger, the preparation process takes a long time, and the cost is higher; Destroyed, the stability of the emulsion is not good, and the effects of vitamin E and the like cannot be effectively protected.

SUMMARY OF THE INVENTION

Aiming at the deficiencies in the prior art, the invention provides a xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors and a preparation method thereof. The preparation method of the invention is simple, no heating is required in the emulsification process, and the required cost is low; the prepared emulsion has good stability, can effectively protect the activity of functional factors, has uniform particle size distribution, and has good rheological properties and anti-oxidation , Moisturizing properties.

Technical scheme of the present invention is as follows:

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

4-20 parts of oil phase, 1-5 parts of emulsifier, 0.1-1 part of alcohol, 0.1-2 parts of vitamin E, 0.02-1 part of sodium hyaluronate, 0.1-3 parts of provitamin B5, 0.1-3 parts of hydrolyzed collagen 0.1-3 parts of wheat protein, 0.1-3 parts of silk protein, 0.1-3 parts of chamomile extract, 0.1-2 parts of xanthan gum, 0.1-2 parts of sodium alginate, 2-15 parts of glycerin, 1,3- 1-6 parts of butanediol, 0.05-0.15 parts of disodium edetate, 0.2-5 parts of trehalose, 0.1-4 parts of hydroxyethyl urea, 40-90 parts of deionized water, 0.05-0.15 parts of preservative .

Preferably according to the present invention, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

6-14 parts of oil phase, 1-3 parts of emulsifier, 0.2-0.6 parts of alcohol, 0.5-1.5 parts of vitamin E, 0.05-0.5 parts of sodium hyaluronate, 0.3-2 parts of provitamin B5, 0.3-2 parts of hydrolyzed collagen 0.3-2 parts of wheat protein, 0.3-2 parts of silk protein, 0.3-1 part of chamomile extract, 0.25-1 part of xanthan gum, 0.25-1 part of sodium alginate, 5-10 parts of glycerin, 1,3- 1-4 parts of butanediol, 0.05-0.15 parts of disodium edetate, 0.5-3 parts of trehalose, 0.3-2 parts of hydroxyethyl urea, 45-82 parts of deionized water, 0.05-0.15 parts of preservative .

Preferably according to the present invention, the oil phase is one or a mixture of two or more of caprylic/capric triglyceride, olive oil, jojoba oil or isopropyl myristate; preferably caprylic/capric glycerin A blend of triesters and jojoba oil.

Preferably according to the present invention, the emulsifier is one or more mixtures of PEG-40 hydrogenated castor oil, glyceryl stearate or PEG-100 glyceryl stearate; preferably PEG-40 hydrogenated castor oil sesame oil.

Preferably according to the present invention, the alcohol is cetostearyl alcohol; cetostearyl alcohol contains 50%-70wt% stearyl alcohol and 20%-35wt% cetyl alcohol.

Preferably according to the present invention, the particle size of the sodium alginate is 50-200 mesh.

Preferably according to the present invention, the preservative is one of methylparaben, phenoxyethanol, bis(hydroxymethyl) imidazolidinyl urea or imidazolidinyl urea; preferably, the preservative is nipagin Parkin methyl ester.

Preferably according to the present invention, the mass ratio of xanthan gum and sodium alginate is (2-4): 1; the addition amounts of xanthan gum and sodium alginate are respectively 0.24wt%-1.1% of the mass of the oil-in-water emulsion wt%.

Preferably, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/capric triglyceride 3-7 parts, jojoba oil 3-7 parts, PEG-40 hydrogenated castor oil 1-3 parts, cetostearyl alcohol 0.2-0.6 parts, vitamin E 0.5-1.5 parts, hyaluronic acid 0.05-0.5 parts of sodium nitrate, 0.3-2 parts of provitamin B5, 0.3-2 parts of hydrolyzed collagen, 0.3-2 parts of wheat protein, 0.3-2 parts of silk protein, 0.3-1 part of chamomile extract, 0.25-2 parts of xanthan gum 1 part, 0.25-1 part of sodium alginate, 5-10 parts of glycerin, 1-4 parts of 1,3-butanediol, 0.05-0.15 parts of disodium edetate, 0.5-3 parts of trehalose, hydroxyethyl 0.3-2 parts of urea, 45-82 parts of deionized water, and 0.05-0.15 parts of methylparaben.

The preferred technical scheme of the present invention is as follows, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/capric triglyceride 4 parts, jojoba oil 3 parts, PEG-40 hydrogenated castor oil 1 part, cetostearyl alcohol 0.4 part, vitamin E 1 part, sodium hyaluronate 0.1 part, provitamin B5 0.5 part , 0.5 parts of hydrolyzed collagen, 0.5 parts of wheat protein, 0.5 parts of silk protein, 0.5 parts of chamomile extract, 1 part of xanthan gum, 0.5 parts of sodium alginate, 6 parts of glycerin, 2 parts of 1,3-butanediol, B 0.1 part of disodium diaminetetraacetic acid (disodium EDTA), 1 part of trehalose, 0.5 part of hydroxyethylurea, 75.8 parts of deionized water, and 0.1 part of methylparaben.

Another preferred technical solution of the present invention is as follows, the xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/capric triglyceride 4 parts, jojoba oil 3 parts, PEG-40 hydrogenated castor oil 1.5 parts, cetostearyl alcohol 0.4 part, vitamin E 1 part, sodium hyaluronate 0.1 part, provitamin B5 0.5 part , 0.5 parts of hydrolyzed collagen, 0.5 parts of wheat protein, 0.5 parts of silk protein, 0.5 parts of chamomile extract, 1 part of xanthan gum, 0.5 parts of sodium alginate, 6 parts of glycerin, 2 parts of 1,3-butanediol, B 0.1 part of disodium diaminetetraacetic acid (disodium EDTA), 1 part of trehalose, 0.5 part of hydroxyethylurea, 75.3 parts of deionized water, 0.1 part of methylparaben.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors comprises steps:

(1) Fully mix the oil phase, emulsifier, alcohol and vitamin E to obtain an oil phase solution;

(2) Sodium hyaluronate, provitamin B5, hydrolyzed collagen, wheat protein, silk protein, chamomile extract, xanthan gum, sodium alginate, glycerin, 1,3-butanediol, ethylenediaminetetraacetic acid dissodium, trehalose and hydroxyethylurea were dissolved in deionized water to obtain an aqueous phase solution;

(3) Add the oil phase solution to the water phase solution and emulsify under stirring at room temperature; then add preservatives and stir at room temperature for 1 to 2 hours to obtain the xanthan gum/sodium alginate composite oil-in-water rich in functional factors lotion.

Preferably according to the present invention, in step (3), the emulsification time is 20-40 minutes; the stirring speed is 1000-6000 rpm.

Technical characteristics and beneficial effects of the present invention:

1, xanthan gum is a kind of non-absorptive water-soluble macromolecule, can be used as thickener and stabilizer; Because xanthan gum aqueous solution is a kind of pseudoplastic fluid, so the adding of xanthan gum of the present invention can give emulsion good of shear thinning. Sodium alginate is a natural polysaccharide. It is not only a commonly used thickener and stabilizer for cosmetics, but also has good air permeability, moisture absorption, moisturizing and antibacterial functions. In the present invention, xanthan gum and sodium alginate are added to the emulsion, and the two play a synergistic effect to form an interface layer on the surface of the O/W droplet to improve the strength of the interface layer, thereby enhancing the stability of the emulsion and effectively protecting the vitamin The activity of functional factors such as E; and make the emulsion have good rheological properties, which is beneficial to the application of emulsion skin care; it can further improve the moisturizing and antibacterial properties of the emulsion, reduce the use of expensive moisturizing functional factors and preservatives, and reduce costs. At the same time improve product safety.

2. The emulsifier preferably used in the present invention is PEG-40 hydrogenated castor oil. This emulsifier has lower irritation and good solubilization, and can realize the dispersion of functional factors such as vitamin E in water to form an oil-in-water emulsion. At the same time, the xanthan gum and sodium alginate used synergistically form a polymer interface layer on the surface of the O/W droplet to improve the strength of the oil-water interface layer, so that the emulsion can achieve long-term preservation of functional factors such as vitamin E. Effective entrapment, reducing the oxidation consumption of vitamin E and others during storage, so that the emulsion has a better anti-oxidation effect during use. In the present invention, disodium EDTA is also added as a chelating agent, which can avoid the chelating effect of sodium alginate and metal ions in the emulsion, and improve the stability of the emulsion. Both sodium hyaluronate and sodium alginate used in the present invention have good film-forming properties and can form a uniform and breathable moisturizing layer on the skin surface. A large number of hydroxyl groups on the molecules can effectively bind water molecules and reduce water loss. In addition, the selected jojoba oil has good anti-oxidation and excellent penetration ability, which can penetrate into the skin, directly replenish the nutrients needed by cell metabolism, and enhance the skin's elasticity and moisturizing ability.

3. The preparation method of the present invention is simple, the emulsification process does not need heating, the operation process is easy to control, and the cost is low. The components in the emulsion of the present invention do not function independently of each other, but interact with each other, so that the particle size distribution of the obtained emulsion is uniform, the stability is good, the activity of the functional factors can be effectively protected, and the rheology is better. Chemical properties and antioxidant moisturizing properties.

Description of drawings

Fig. 1 is the optical micrograph of the oil-in-water emulsion prepared in Example 3.

Fig. 2 is the viscosity-shear rate relation diagram of the oil-in-water emulsion prepared in Example 3.

Fig. 3 is a photo comparison chart of the oil-in-water emulsion prepared in Example 3 without freezing and after being frozen and thawed at -18°C.

Detailed ways

The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

The test methods described in the examples are conventional methods unless otherwise specified; all reagents and raw materials used are commercially available unless otherwise specified.

In the examples, jojoba oil used is available from Guangzhou Anpin Chemical Co., Ltd.; PEG-40 hydrogenated castor oil is available from Shandong Youso Chemical Technology Co., Ltd.; sodium hyaluronate is available from Shandong Freda Company; Collagen, wheat protein, silk protein, chamomile extract, available from Huzhou Jiamei Biochemical Products Co., Ltd.; sodium alginate, available from Qingdao Mingyue Seaweed Company, viscosity is 500cps, particle size is 100 mesh; cetostearyl alcohol, Guangzhou Available from Suixin Chemical Co., Ltd.

Example 1

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 4g, Jojoba Oil 3g, PEG-40 Hydrogenated Castor Oil 1g, Cetostearyl Alcohol 0.4g, Vitamin E 1g, Sodium Hyaluronate 0.1g, Provitamin B5 0.5g, Hydrolyzed Collagen 0.5g, wheat protein 0.5g, silk protein 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium edetate ( Disodium EDTA) 0.1g, trehalose 1g, hydroxyethylurea 0.5g, deionized water 75.8g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors comprises steps:

Xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium EDTA 0.1g, sodium hyaluronate 0.1g, trehalose 1g, hydroxyethylurea 0.5g, provitamin Dissolve 0.5g of B5, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of silk protein, and 0.5g of chamomile extract in 75.8g of deionized water, and stir for 2 hours to obtain an aqueous phase solution;

Mix 1g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil, and 1g of vitamin E, and heat and stir at 50°C to obtain a uniform oil phase solution;

Under stirring conditions, slowly inject the oil phase into the water phase, stir and emulsify at room temperature at 3000rpm for 30 minutes; finally add 0.1g of methyl paraben, stir at room temperature for 2 hours to obtain xanthan gum/sodium alginate rich in functional factors Complex oil-in-water emulsion.

Example 2

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 4g, Jojoba Oil 3g, PEG-40 Hydrogenated Castor Oil 1g, Cetostearyl Alcohol 0.4g, Vitamin E 1g, Sodium Hyaluronate 0.1g, Provitamin B5 0.5g, Hydrolyzed Collagen 0.5g, wheat protein 0.5g, silk protein 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.25g, glycerin 6g, 1,3-butanediol 2g, disodium edetate ( Disodium EDTA) 0.1g, trehalose 1g, hydroxyethylurea 0.5g, deionized water 76.05g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors comprises steps:

Xanthan gum 1g, sodium alginate 0.25g, glycerin 6g, 1,3-butanediol 2g, disodium EDTA 0.1g, sodium hyaluronate 0.1g, trehalose 1g, hydroxyethylurea 0.5g, provitamin 0.5g of B5, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of silk protein, and 0.5g of chamomile extract were dissolved in 76.05g of deionized water, and stirred for 2 hours to obtain an aqueous phase solution;

Mix 1g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil, and 1g of vitamin E, and heat and stir at 50°C to obtain a uniform oil phase solution;

Under stirring conditions, slowly inject the oil phase into the water phase, stir and emulsify at room temperature at 3000rpm for 30 minutes; finally add 0.1g of methyl paraben, stir at room temperature at 1000rpm for 2 hours to obtain xanthan gum/sodium alginate rich in functional factors Complex oil-in-water emulsion.

Example 3

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 4g, Jojoba Oil 3g, PEG-40 Hydrogenated Castor Oil 1.5g, Cetostearyl Alcohol 0.4g, Vitamin E 1g, Sodium Hyaluronate 0.1g, Provitamin B5 0.5g, Hydrolyzed Collagen Egg white 0.5g, wheat protein 0.5g, silk protein 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, edetate disodium (Disodium EDTA) 0.1g, trehalose 1g, hydroxyethylurea 0.5g, deionized water 75.3g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors comprises steps:

Xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium EDTA 0.1g, sodium hyaluronate 0.1g, trehalose 1g, hydroxyethylurea 0.5g, provitamin Dissolve 0.5g of B5, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of silk protein, and 0.5g of chamomile extract in 75.3g of deionized water, and stir for 2 hours to obtain an aqueous phase solution;

Mix 1.5g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil, and 1g of vitamin E, and heat and stir at 50°C to obtain a uniform oil phase solution;

Under stirring conditions, slowly inject the oil phase into the water phase, stir and emulsify at room temperature at 3000rpm for 30 minutes; finally add 0.1g of methyl paraben, stir at room temperature at 1000rpm for 2 hours to obtain xanthan gum/sodium alginate rich in functional factors Complex oil-in-water emulsion.

Figure 1 is an optical microscope image of the oil-in-water emulsion prepared in this example; it can be seen from the figure that the particle size distribution of the obtained emulsion is uniform, and the particle size is 5 μm.

Fig. 2 is the viscosity-shear rate relationship figure of the oil-in-water emulsion prepared in this embodiment; As can be seen from the figure, the viscosity of the emulsion decreases gradually with the increase of the shear rate, indicating that the prepared emulsion has good shear rate. Shear-thinning properties.

Figure 3 is a photo comparison of the oil-in-water emulsion prepared in this example without freezing and thawing after freezing at -18°C; it can be seen from the figure that although the emulsion freezes and solidifies after being frozen at -18°C, it will return to room temperature. There was no delamination, and it was still a uniform and fluid emulsion, and after repeated tests, the emulsion did not delaminate.

Example 4

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 4g, Jojoba Oil 3g, PEG-40 Hydrogenated Castor Oil 2g, Cetostearyl Alcohol 0.4g, Vitamin E 1g, Sodium Hyaluronate 0.1g, Provitamin B5 0.5g, Hydrolyzed Collagen 0.5g, wheat protein 0.5g, silk protein 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium edetate ( Disodium EDTA) 0.1g, trehalose 1g, hydroxyethylurea 0.5g, deionized water 74.8g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors comprises steps:

Xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium EDTA 0.1g, sodium hyaluronate 0.1g, trehalose 1g, hydroxyethylurea 0.5g, provitamin Dissolve 0.5g of B5, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of silk protein, and 0.5g of chamomile extract in 74.8g of deionized water, and stir for 2 hours to obtain an aqueous phase solution;

Mix 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil, and 1g of vitamin E, and heat and stir at 50°C to obtain a uniform oil phase solution;

Under stirring conditions, slowly inject the oil phase into the water phase, stir and emulsify at room temperature at 3000rpm for 30 minutes; finally add 0.1g of methyl paraben, stir at room temperature at 1000rpm for 2 hours to obtain xanthan gum/sodium alginate rich in functional factors Complex oil-in-water emulsion.

Example 5

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 4g, Jojoba Oil 3g, PEG-40 Hydrogenated Castor Oil 2g, Cetostearyl Alcohol 0.4g, Vitamin E 1g, Sodium Hyaluronate 0.1g, Provitamin B5 0.5g, Hydrolyzed Collagen 0.5g, wheat protein 0.5g, silk protein 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium edetate ( Disodium EDTA) 0.1g, trehalose 1g, hydroxyethylurea 0.5g, deionized water 74.8g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors comprises steps:

Xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium EDTA 0.1g, sodium hyaluronate 0.1g, trehalose 1g, hydroxyethylurea 0.5g, provitamin Dissolve 0.5g of B5, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of silk protein, and 0.5g of chamomile extract in 74.8g of deionized water, and stir for 2 hours to obtain an aqueous phase solution;

Mix 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil, and 1g of vitamin E, and heat and stir at 50°C to obtain a uniform oil phase solution;

Under stirring conditions, slowly inject the oil phase into the water phase, stir and emulsify at room temperature at 4000rpm for 30 minutes; finally add 0.1g of methyl paraben, stir at room temperature at 1000rpm for 2 hours to obtain xanthan gum/sodium alginate rich in functional factors Complex oil-in-water emulsion.

Example 6

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 4g, Jojoba Oil 3g, PEG-40 Hydrogenated Castor Oil 2g, Cetostearyl Alcohol 0.4g, Vitamin E 1g, Sodium Hyaluronate 0.1g, Provitamin B5 0.5g, Hydrolyzed Collagen 0.5g, wheat protein 0.5g, silk protein 0.5g, chamomile extract 0.5g, xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium edetate ( Disodium EDTA) 0.1g, trehalose 1g, hydroxyethylurea 0.5g, deionized water 74.8g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors comprises steps:

Xanthan gum 1g, sodium alginate 0.5g, glycerin 6g, 1,3-butanediol 2g, disodium EDTA 0.1g, sodium hyaluronate 0.1g, trehalose 1g, hydroxyethylurea 0.5g, provitamin Dissolve 0.5g of B5, 0.5g of hydrolyzed collagen, 0.5g of wheat protein, 0.5g of silk protein, and 0.5g of chamomile extract in 74.8g of deionized water, and stir for 2 hours to obtain an aqueous phase solution;

Mix 2g of PEG-40 hydrogenated castor oil, 0.4g of cetostearyl alcohol, 4g of caprylic/capric triglyceride, 3g of jojoba oil, and 1g of vitamin E, and heat and stir at 50°C to obtain a uniform oil phase solution;

Under stirring conditions, slowly inject the oil phase into the water phase, stir and emulsify at room temperature at 6000rpm for 30 minutes; finally add 0.1g of methyl paraben, stir at room temperature at 1000rpm for 2 hours to obtain xanthan gum/sodium alginate rich in functional factors Complex oil-in-water emulsion.

Example 7

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 3g, Jojoba Oil 5g, PEG-40 Hydrogenated Castor Oil 3g, Cetostearyl Alcohol 0.2g, Vitamin E 0.5g, Sodium Hyaluronate 0.05g, Provitamin B5 0.3g, Hydrolyzed Collagen Protein 0.3g, Wheat Protein 0.3g, Silk Protein 0.3g, Chamomile Extract 0.3g, Xanthan Gum 0.25g, Sodium Alginate 1g, Glycerin 5g, 1,3-Butanediol 1g, Disodium EDTA (Disodium EDTA) 0.1g, trehalose 1g, hydroxyethylurea 0.5g, deionized water 76.9g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is as described in Example 1.

Example 8

A xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is made of the following raw materials in parts by mass:

Caprylic/Capric Triglyceride 7g, Jojoba Oil 7g, PEG-40 Hydrogenated Castor Oil 3g, Cetostearyl Alcohol 0.6g, Vitamin E 1.5g, Sodium Hyaluronate 0.5g, Provitamin B5 2g, Hydrolyzed Collagen 2g, wheat protein 2g, silk protein 2g, chamomile extract 2g, xanthan gum 1g, sodium alginate 1g, glycerin 10g, 1,3-butanediol 4g, ethylenediaminetetraacetic acid disodium (EDTA disodium) 0.1 g, trehalose 3g, hydroxyethylurea 2g, deionized water 48.3g, methylparaben 0.1g.

The preparation method of the above-mentioned xanthan gum/sodium alginate composite oil-in-water emulsion rich in functional factors is as described in Example 1.

Comparative Example 1

An oil-in-water emulsion, the composition of parts by mass is as described in Example 1, the difference is: no xanthan gum is added; other raw materials and components are the same as in Example 1.

Its preparation method is consistent with embodiment 1.

Comparative Example 2

An oil-in-water emulsion, the composition of parts by mass is as described in Example 1, the difference is that the addition of xanthan gum is 0.1g, and the addition of sodium alginate is 0.1g; other raw materials and components are the same as in Example 1 .

Its preparation method is consistent with embodiment 1.

Comparative Example 3

An oil-in-water emulsion, the composition of parts by mass is as described in Example 1, the difference is: xanthan gum is replaced by methyl cellulose, and the addition is 0.5 g; other raw materials and components are the same as in Example 1.

Its preparation method is consistent with embodiment 1.

Comparative Example 4

An oil-in-water emulsion, the composition of which is as described in Example 1 in parts by mass, except that disodium EDTA is not added; other raw materials and components are the same as in Example 1.

Its preparation method is consistent with embodiment 1.

Comparative Example 5

An oil-in-water emulsion, the composition of which is as described in Example 3 in parts by mass, except that sodium alginate is not added; other raw materials and components are the same as in Example 3.

Its preparation method is consistent with embodiment 3.

Comparative Example 6

An oil-in-water emulsion, the composition of mass parts is as described in Example 3, the difference is: the addition of xanthan gum is 0.5g, and the addition of sodium alginate is 0.1g; other raw materials and components are the same as in Example 3 .

Its preparation method is consistent with embodiment 3.

Comparative Example 7

An oil-in-water emulsion, the composition of the mass parts is as described in Example 1, the difference is: the addition of sodium alginate is 0.1g; other raw materials and components are the same as in Example 3.

Its preparation method is consistent with embodiment 3.

Test Example 1

According to the national standard GB/T 29665-2013, the oil-in-water emulsions prepared in Example 1 and Comparative Examples 1-4 were tested for cold resistance, heat resistance and centrifugal stability.

The test results are shown in Table 1 below. It can be seen from Table 1 that the addition of xanthan gum and the ratio of xanthan gum to sodium alginate have an important impact on the stability of the emulsion. If no xanthan gum is added or the quality of xanthan gum and sodium alginate is relatively small, although the prepared emulsion does not separate after centrifugation and at low temperature, its heat resistance stability is relatively poor. The emulsion without disodium EDTA is placed at room temperature, and stratification occurs in a short time, and the cold resistance, heat resistance and centrifugal stability are not good, indicating that disodium EDTA can be used as a chelating agent to avoid the interaction between sodium alginate and metal ions in the emulsion. The chelation effect improves the stability of the emulsion; the xanthan gum is replaced by methyl cellulose, and the cold resistance and heat resistance of the gained emulsion are not good, which illustrates the importance of the specific xanthan gum of the present invention for stability.

Table 1 Cold resistance, heat resistance and centrifugal stability test data

name Low temperature stability (-4°C) High temperature stability (50℃) Centrifugal stability (2000rpm 30min) Example 1 Unlayered Unlayered Unlayered Comparative Example 1 Unlayered layered Unlayered Comparative Example 2 Unlayered layered Unlayered Comparative Example 3 layered layered Unlayered Comparative Example 4 layered layered layered

Test example 2

Taking the back of the hand as the test area, 10 people were selected to conduct a moisture retention test on the lotions obtained in Comparative Examples 5-7, Example 3, and the purchased commercial lotions. The instrument selected for the skin moisture content test is a digital skin moisture detection pen, and no water can exist on the skin surface during the test. The tester applied lotion on his left hand, but did not apply lotion on his right hand; after washing his hands for 1 minute, the tester measured the moisture content, which was used as the skin moisture content before the test, then applied lotion on his left hand, and tested the skin moisture content on the back of his left and right hands 4 hours later. Take three different locations each time to test the moisture content of the skin, the test results are expressed as a percentage, and the test results of ten people are averaged.

The test results are shown in Table 2. It can be seen from the table that the sodium alginate added in Example 3 is 0.5wt%. After 4 hours, the water content of the skin of the left hand coated with lotion is obviously higher than that of the right hand without lotion, and is higher than that of the right hand coated with lotion. The moisture content of the test skin area with the commercial emulsion is also high; the emulsion obtained in Comparative Examples 5-7, the skin moisture content after 4 hours is obviously lower than the test result of Example 3. This shows that the addition of sodium alginate and the ratio of its addition to xanthan gum affect the moisturizing effect of the emulsion. A certain amount of sodium alginate makes the moisturizing performance of the emulsion better; at the same time, when the proportion of xanthan gum is large, the emulsion has Larger viscosity, less water loss, the emulsion has better moisturizing effect.

Table 2 Humidity test data

Claims (10)

1. a kind of compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, which is characterized in that including following quality The raw material of part is made:

4~20 parts of oily phase, 1~5 part of emulsifier, 0.1~1 part of alcohol, 0.1~2 part of vitamin E, 0.02~1 part of Sodium Hyaluronate, 0.1~3 part of dexpanthenol, 0.1~3 part of Hydrolyzed Collagen, 0.1~3 part of wheat gluten, 0.1~3 part of fibroin, ocean 0.1~3 part of Flos Chrysanthemi extract, 0.1~2 part of xanthan gum, 0.1~2 part of sodium alginate, 2~15 parts of glycerol, 1,3-BDO 1~6 Part, 0.05~0.15 part of disodium ethylene diamine tetraacetate, 0.2~5 part of trehalose, 0.1~4 part of ethoxy urea, deionized water 40~ 90 parts, 0.05~0.15 part of preservative.

2. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists In the raw material including following mass parts is made:

6~14 parts of oily phase, 1~3 part of emulsifier, 0.2~0.6 part of alcohol, 0.5~1.5 part of vitamin E, Sodium Hyaluronate 0.05~ 0.5 part, 0.3~2 part of dexpanthenol, 0.3~2 part of Hydrolyzed Collagen, 0.3~2 part of wheat gluten, fibroin 0.3~ 2 parts, 0.3~1 part of camomile extract, 0.25~1 part of xanthan gum, 0.25~1 part of sodium alginate, 5~10 parts of glycerol, 1,3- fourth 1~4 part of glycol, 0.05~0.15 part of disodium ethylene diamine tetraacetate, 0.5~3 part of trehalose, 0.3~2 part of ethoxy urea, go from 45~82 parts of sub- water, 0.05~0.15 part of preservative.

3. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists In the oil is mutually one or both of caprylic/capric triglyceride, olive oil, jojoba oil or isopropyl myristate Above mixture；The preferably mixture of caprylic/capric triglyceride and jojoba oil.

4. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists In including one or more in the following conditions:

A, the emulsifier is one of Cremophor RH40, stearine or PEG-100 stearine Or two or more mixture；Preferably Cremophor RH40；

B, the alcohol is cetostearyl alcohol；Octadecyl alcolol and 20%~35wt% in cetostearyl alcohol containing 50%~70wt% Hexadecanol；

C, the granularity of the sodium alginate is 50~200 mesh；

D, the preservative is one in methylparaben, Phenoxyethanol, Bis(hydroxymethyl)imidazolidinyl urea or imidazolidinyl urea Kind；Preferably, the preservative is methylparaben.

5. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists In the mass ratio of the xanthan gum and sodium alginate is (2~4): 1；The additional amount of xanthan gum and sodium alginate is respectively water packet 0.24wt%~1.1wt% of fat liquor quality.

6. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists In the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts is made:

3~7 parts of caprylic/capric triglyceride, 3~7 parts of jojoba oil, 1~3 part of Cremophor RH40, cetostearyl alcohol 0.2~0.6 part, 0.5~1.5 part of vitamin E, 0.05~0.5 part of Sodium Hyaluronate, 0.3~2 part of dexpanthenol, hydrolysis 0.3~2 part of collagen, 0.3~2 part of wheat gluten, 0.3~2 part of fibroin, 0.3~1 part of camomile extract, xanthan 0.25~1 part of glue, 0.25~1 part of sodium alginate, 5~10 parts of glycerol, 1~4 part of 1,3-BDO, disodium ethylene diamine tetraacetate 0.05~0.15 part, 0.5~3 part of trehalose, 0.3~2 part of ethoxy urea, 45~82 parts of deionized water, methylparaben 0.05 ~0.15 part.

7. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists In the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts is made:

4 parts of caprylic/capric triglyceride, 3 parts of jojoba oil, 1 part of Cremophor RH40,0.4 part of cetostearyl alcohol, dimension life It is E1 parts plain, 0.1 part of Sodium Hyaluronate, 0.5 part of dexpanthenol, 0.5 part of Hydrolyzed Collagen, 0.5 part of wheat gluten, silk 0.5 part of albumen, 0.5 part of camomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 2 parts of 1,3-BDO, second 0.1 part of edetate disodium (EDETATE SODIUM), 1 part of trehalose, 0.5 part of ethoxy urea, 75.8 parts of deionized water, Metagin 0.1 part of ester.

8. being rich in the compound oil-in-water emulsion of xanthan gum/sodium alginate of function factor according to claim 1, feature exists In the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor, the raw material including following mass parts is made:

4 parts of caprylic/capric triglyceride, 3 parts of jojoba oil, 1.5 parts of Cremophor RH40,0.4 part of cetostearyl alcohol, dimension Raw E1 parts of element, 0.1 part of Sodium Hyaluronate, 0.5 part of dexpanthenol, 0.5 part of Hydrolyzed Collagen, 0.5 part of wheat gluten, silkworm 0.5 part of silk-fibroin, 0.5 part of camomile extract, 1 part of xanthan gum, 0.5 part of sodium alginate, 6 parts of glycerol, 2 parts of 1,3-BDO, 0.1 part of disodium ethylene diamine tetraacetate (EDETATE SODIUM), 1 part of trehalose, 0.5 part of ethoxy urea, 75.3 parts of deionized water, nipalgin 0.1 part of methyl esters.

9. the compound oil-in-water emulsion of xanthan gum/sodium alginate as described in claim 1-8 any one rich in function factor Preparation method, comprising steps of

(1) oily phase, emulsifier, pure and mild vitamin E are sufficiently mixed uniform oil-phase solution；

(2) by Sodium Hyaluronate, dexpanthenol, Hydrolyzed Collagen, wheat gluten, fibroin, camomile extract, Huang Virgin rubber, sodium alginate, glycerol, 1,3 butylene glycol, disodium ethylene diamine tetraacetate, trehalose and ethoxy urea are dissolved in deionized water Obtain aqueous phase solution；

(3) oil-phase solution is added in aqueous phase solution, it is emulsified that condition is stirred at room temperature；Then preservative is added, room temperature is stirred It mixes 1~2 hour, obtains the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor.

10. the preparation side of the compound oil-in-water emulsion of xanthan gum/sodium alginate rich in function factor according to claim 9 Method, which is characterized in that in step (3), the emulsification times are 20~40min；Speed of agitator is 1000~6000rpm.