CN108896426A - Dressing anthemorrhagic performance in-vitro evaluation system and method - Google Patents
Dressing anthemorrhagic performance in-vitro evaluation system and method Download PDFInfo
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- CN108896426A CN108896426A CN201810445847.9A CN201810445847A CN108896426A CN 108896426 A CN108896426 A CN 108896426A CN 201810445847 A CN201810445847 A CN 201810445847A CN 108896426 A CN108896426 A CN 108896426A
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- 238000011156 evaluation Methods 0.000 title claims abstract description 57
- 238000000338 in vitro Methods 0.000 title claims abstract description 48
- 238000000034 method Methods 0.000 title abstract description 9
- 238000012360 testing method Methods 0.000 claims abstract description 45
- 238000003556 assay Methods 0.000 claims abstract description 24
- 230000007246 mechanism Effects 0.000 claims abstract description 23
- 238000012545 processing Methods 0.000 claims abstract description 19
- 230000017531 blood circulation Effects 0.000 claims abstract description 8
- 239000002274 desiccant Substances 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 8
- 239000000523 sample Substances 0.000 claims description 16
- 239000008280 blood Substances 0.000 claims description 15
- 210000004369 blood Anatomy 0.000 claims description 15
- 238000002347 injection Methods 0.000 claims description 13
- 239000007924 injection Substances 0.000 claims description 13
- 229910000831 Steel Inorganic materials 0.000 claims description 10
- 239000010959 steel Substances 0.000 claims description 10
- 210000004204 blood vessel Anatomy 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 3
- 239000013068 control sample Substances 0.000 claims description 2
- 238000010171 animal model Methods 0.000 abstract description 11
- 238000001514 detection method Methods 0.000 abstract description 11
- 238000002955 isolation Methods 0.000 abstract description 7
- 238000010586 diagram Methods 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000013401 experimental design Methods 0.000 description 3
- 239000000741 silica gel Substances 0.000 description 3
- 229910002027 silica gel Inorganic materials 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005587 bubbling Effects 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010616 electrical installation Methods 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N5/00—Analysing materials by weighing, e.g. weighing small particles separated from a gas or liquid
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention discloses a kind of dressing anthemorrhagic performance in-vitro evaluation system and method, is related to medical treatment detection device technical field, when solving existing animal model evaluation detection dressing anthemorrhagic performance, as a result inaccuracy, can not quantify, and the technical issues of higher cost.In dressing anthemorrhagic performance in-vitro evaluation system of the present invention, assay balance is equipped with the test model mechanism for measuring the blood flow reduced rate for flowing through dressing, the test model mechanism is communicated with several bubblers by suction pipeline, and the front end of suction pipeline is serially connected with biological air-isolation filter；Gas flow dryer becomes one with number bubbler, and the drying chamber of gas flow dryer is provided with desiccant；Operation touching device is connect with gas flow dryer, and operates the execution that touching device is used for permanent vacuum suction operation；Data processing equipment is connect with assay balance and operation touching device respectively, and data processing equipment is used to acquire, handle data, and result is exported.
Description
Technical field
The present invention relates to medical treatment detection device technical field, in particular to a kind of dressing anthemorrhagic performance in-vitro evaluation system and
Method.
Background technique
Currently, in the prior art, the evaluation detection of dressing anthemorrhagic performance is usually to be operated using animal model.
However, present inventor find, using animal model evaluation detection dressing anthemorrhagic performance when, be easy exist with
Lower defect：
Experimental animal has differences with human body, evaluation testing result inaccuracy；Experimental animal is consumed, animal guarantor is unfavorable for
Shield；Experimental design is relative complex, as a result not energetic, it is difficult to be compared to the anthemorrhagic performance of dressing；Evaluate testing cost compared with
It is high.
Therefore, how a kind of dressing anthemorrhagic performance in-vitro evaluation system and method are provided, can be realized in vitro to dressing
Anthemorrhagic performance carries out evaluation detection, it has also become the technical issues of those skilled in the art's urgent need to resolve.
Summary of the invention
The purpose of the present invention is to provide a kind of dressing anthemorrhagic performance in-vitro evaluation system and method, existing dynamic to solve
When object model evaluation detects dressing anthemorrhagic performance, as a result inaccuracy, can not quantify, and the technical issues of higher cost.
The present invention provides a kind of dressing anthemorrhagic performance in-vitro evaluation system, including：Assay balance is set on the assay balance
There is the test model mechanism for measuring the blood flow reduced rate for flowing through dressing, the test model mechanism passes through suction pipeline
Several bubblers are communicated with, and the front end of the suction pipeline is serially connected with biological air-isolation filter；Gas flow dryer, the air-flow
Drier becomes one with several bubblers, and the drying chamber of the gas flow dryer is provided with desiccant；Operation touches dress
It sets, the operation touching device is connect with the gas flow dryer, and the operation touching device is used for permanent vacuum suction operation
Execution；Data processing equipment, the data processing equipment are connect with the assay balance and the operation touching device respectively,
And the data processing equipment is used to acquire, handle data, and result is exported.
When practical application, the test model mechanism includes：Disposable sample holding device, the disposable sample holder
Device includes：Blood vessel equipped with human whole blood, and the disposable syringe equipped with test sample or control sample；It is described
Disposable syringe is communicated with injection needle, and the injection needle protrudes into the human whole blood in the blood vessel.
Wherein, the test model mechanism further includes：Spring touches ball and is loaded structure, and the spring touches the ball structure that is loaded and is used for
Clamp the disposable syringe.
Specifically, the spring touches the ball structure that is loaded and includes：Be loaded ontology, and the ontology that is loaded is equipped with described for clamping
The holding tank of disposable syringe is additionally provided with groove that is vertical with the holding tank and being connected to setting on the ontology that is loaded, and
The groove is provided with compressed spring；One end of the compressed spring is connect with the groove, the other end is connected with steel ball, and institute
It states steel ball and contacts setting with the disposable syringe.
Further, be equipped at intervals with three groups on the ontology that is loaded described in holding tank and the groove, groove described in every group
Inside it is respectively arranged with a pair of compressed spring and the steel ball.
Further, the test model mechanism further includes：Fast lifting device, the fast lifting device are located at institute
State the top of assay balance；The fast lifting device includes：Rack gear, and with the rack gear meshed gears；The spring
It touches the ball structure that is loaded to connect with the gear, and can be moved up and down along the rack gear.
Still further, the fast lifting device further includes：Clamping screw, the clamping screw are used in the spring
It touches ball and is loaded after structure is in proper height and be locked.
Preferably, several bubblers, which are negative, presses bubble counter, and counting mode is photoelectric counting.
Compared with the existing technology, dressing anthemorrhagic performance in-vitro evaluation system of the present invention has the advantage that：
In dressing anthemorrhagic performance in-vitro evaluation system provided by the invention, including：Assay balance, gas flow dryer, operation
Touching device and data processing equipment；Wherein, assay balance is equipped with for measuring the blood flow reduced rate for flowing through dressing
Test model mechanism, which is communicated with several bubblers by suction pipeline, and the front end of suction pipeline is serially connected with
Biological air-isolation filter；Specifically, gas flow dryer becomes one with number bubbler, and in the drying chamber of gas flow dryer
Equipped with desiccant；Further, operation touching device is connect with gas flow dryer, and is operated touching device and be used for permanent vacuum suction
The execution of operation；Data processing equipment is connect with assay balance and operation touching device respectively, and data processing equipment is for adopting
Collection, processing data, and result is exported.From this analysis, dressing anthemorrhagic performance in-vitro evaluation system provided by the invention, energy
It is enough in the anthemorrhagic performance of in-vitro evaluation detection dressing, to solve existing all when the existing detection using animal model evaluation
More problems, specially experimental animal have differences with human body, evaluation testing result inaccuracy；Experimental animal is consumed, is unfavorable for moving
Object protection；Experimental design is relative complex, as a result not energetic, it is difficult to be compared to the anthemorrhagic performance of dressing；Evaluation detection at
This is higher.
The present invention also provides a kind of dressing anthemorrhagic performance in-vitro evaluation methods, including：Using assay balance and test model
Mechanism perseverance vacuum suction measures the blood flow reduced rate for flowing through dressing, and passes through d=(Vi-VfThe formula manipulation data of)/t；
In formula：D --- flow-reduction, every square of second (μ g/s of microgram2)；Vi--- initial flow, microgram are (μ g/s) per second；Vf--- most
Whole flow, microgram are (μ g/s) per second；T --- the time interval between initial flow and final flow rate is 30s, second (s).
Wherein, the permanent vacuum suction is -4kPa ± 0.1kPa.
The dressing anthemorrhagic performance in-vitro evaluation method is with above-mentioned dressing anthemorrhagic performance in-vitro evaluation system relative to existing
Advantage possessed by technology is identical, and details are not described herein.
Detailed description of the invention
It, below will be to specific in order to illustrate more clearly of the specific embodiment of the invention or technical solution in the prior art
Embodiment or attached drawing needed to be used in the description of the prior art be briefly described, it should be apparent that, it is described below
Attached drawing is some embodiments of the present invention, for those of ordinary skill in the art, before not making the creative labor
It puts, is also possible to obtain other drawings based on these drawings.
Fig. 1 is the structural schematic diagram of dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention；
Fig. 2 is that the disposable of prototype structure is tested in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of sample holding device；
Fig. 3 is that the spring of test prototype structure in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention touches
Ball is loaded the structural schematic diagram of structure；
Fig. 4 is the quick liter that prototype structure is tested in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of falling unit；
Fig. 5 is the structural schematic diagram of number bubbler in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention；
Fig. 6 is gas flow dryer and number bubbler in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
Structural schematic diagram.
In figure：1- assay balance；2- test model mechanism；3- number bubbler；4- biology air-isolation filter；5-
Gas flow dryer；51- desiccant；6- operates touching device；7- data processing equipment；The disposable sample holding device of 21-；
211- blood vessel；212- disposable syringe；213- injection needle；22- spring touches ball and is loaded structure；221- is loaded this
Body；222- compressed spring；223- steel ball；23- fast lifting device；231- rack gear；232- gear；233- locking screw
Bolt.
Specific embodiment
Technical solution of the present invention is clearly and completely described below in conjunction with attached drawing, it is clear that described implementation
Example is a part of the embodiment of the present invention, instead of all the embodiments.Based on the embodiments of the present invention, ordinary skill
Personnel's every other embodiment obtained without making creative work, shall fall within the protection scope of the present invention.
In the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, merely to
Convenient for description the present invention and simplify description, rather than the device or element of indication or suggestion meaning must have a particular orientation,
It is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.In addition, term " first ", " second ",
" third " is used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
To be mechanical connection, it is also possible to be electrically connected；It can be directly connected, can also indirectly connected through an intermediary, it can be with
It is the connection inside two elements.For the ordinary skill in the art, it can understand that above-mentioned term exists with concrete condition
Concrete meaning in the present invention.
Fig. 1 is the structural schematic diagram of dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention.
As shown in Figure 1, the embodiment of the present invention provides a kind of dressing anthemorrhagic performance in-vitro evaluation system, including：Assay balance
1, assay balance 1 is equipped with the test model mechanism 2 for measuring the blood flow reduced rate for flowing through dressing, test model mechanism
2 are communicated with several bubblers 3 by suction pipeline, and the front end of suction pipeline is serially connected with biological air-isolation filter 4；Pneumatic conveying drying
Device 5, gas flow dryer 5 becomes one with number bubbler 3, and the drying chamber of gas flow dryer 5 is provided with desiccant 51；Operation touching
Device 6 is touched, operation touching device 6 is connect with gas flow dryer 5, and is operated touching device 6 and be used for holding for permanent vacuum suction operation
Row；Data processing equipment 7, data processing equipment 7 is connect with assay balance 1 and operation touching device 6 respectively, and data processing fills
7 are set for acquiring, handling data, and result is exported.
Compared with the existing technology, dressing anthemorrhagic performance in-vitro evaluation system described in the embodiment of the present invention has following excellent
Gesture：
In dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention, including：Assay balance 1, pneumatic conveying drying
Device 5 operates touching device 6 and data processing equipment 7；Wherein, assay balance 1 is equipped with for measuring the blood for flowing through dressing
The test model mechanism 2 of flow quantity reduced rate, the test model mechanism 2 are communicated with several bubblers 3, and suction tube by suction pipeline
The front end on road is serially connected with biological air-isolation filter 4；Specifically, gas flow dryer 5 becomes one with number bubbler 3, and gas
The drying chamber of flash dryer 5 is provided with desiccant 51；Further, operation touching device 6 is connect with gas flow dryer 5, and is grasped
Make touching device 6 for execution that permanent vacuum suction operates；Data processing equipment 7 touches dress with assay balance 1 and operation respectively
6 connections are set, and data processing equipment 7 is used to acquire, handle data, and result is exported.From this analysis, the present invention is implemented
The dressing anthemorrhagic performance in-vitro evaluation system that example provides can be used in the anthemorrhagic performance of in-vitro evaluation detection dressing, to solve
Existing problems, specially experimental animal have differences with human body, evaluate when the existing detection using animal model evaluation
Testing result inaccuracy；Experimental animal is consumed, animal protection is unfavorable for；Experimental design is relative complex, as a result not energetic, it is difficult to
The anthemorrhagic performance of dressing is compared；It is higher to evaluate testing cost.
Wherein, in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention, above-mentioned biology air-isolation mistake
Filter 4 is hydrophobic filter；Desiccant 51 in said flow drier 5 is Bibulous Silica Gel；Above-mentioned perseverance vacuum suction operation
For -4kPa ± 0.1kPa.
Fig. 2 is that the disposable of prototype structure is tested in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of sample holding device.
When practical application, as shown in Fig. 2, above-mentioned test model mechanism 2 may include：Disposable sample holding device 21,
The disposable sample holding device 21 may include：Blood vessel 211 equipped with human whole blood, and test sample or right is housed
The disposable syringe 212 of product in the same old way；The disposable syringe 212 is communicated with injection needle 213, and injection needle 213 protrudes into blood
In human whole blood in container 211.
It should be added that, blood is contacted because test uses, if the sample holding device in test model herein
It is use repeatly, testing crew can be in biological safety hazards；Therefore, design is considered as high primary of availability
Property use consumptive material, by proving and inquiring into repeatedly, finally determine and use disposable syringe that specification is 1mL as hemostatic material
Expect the clamping device of sample；Also, the injection gauge of connection is 0.2mm-0.3mm.
Fig. 3 is that the spring of test prototype structure in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention touches
Ball is loaded the structural schematic diagram of structure.
Wherein, as shown in figure 3, above-mentioned test model mechanism 2 can also include：Spring touches ball and is loaded structure 22, the spring
Touch ball be loaded structure 22 can be used in clamp disposable syringe 212.The design of ball-type clamping is touched using spring, one hand just can be complete
At the handling of sample holding device, right-hand man can be operated, while improving the convenience of operation, it is ensured that it tests process
In stability.
Specifically, as shown in figure 3, above-mentioned spring touches the ball structure 22 that is loaded may include：Be loaded ontology 221, this is loaded this
Body 221 is equipped with holding tank for clamping disposable syringe 212, be additionally provided on the ontology 221 that is loaded it is vertical with holding tank and
It is connected to the groove of setting, and groove is provided with compressed spring 222；One end of the compressed spring 222 is connect with groove, the other end connects
It is connected to steel ball 223, and steel ball 223 contacts setting with disposable syringe 212.
Further, as shown in figure 3, three groups of holding tanks and groove can be equipped at intervals on the above-mentioned ontology 221 that is loaded, and it is every
Group groove in be respectively arranged with a pair of of compressed spring 222 and steel ball 223, thus spring touch ball be loaded structure 22 can simultaneously clamping three
Disposable syringe 212, and then effectively improve checkability.
Fig. 4 is the quick liter that prototype structure is tested in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
The structural schematic diagram of falling unit.
Further, as shown in figure 4, above-mentioned test model mechanism 2 can also include：Fast lifting device 23, quickly
Lifting device 23 is located at the top of assay balance 1；The fast lifting device 23 may include：Rack gear 231, and with rack gear 231
Meshed gears 232；When specific assembly, spring touches the ball structure 22 that is loaded and connect with gear 232, and can be along about 231 rack gear
It is mobile, to realize that quick adjustment spring touches ball and is loaded the height of structure 22 and disposable syringe 212.
Still further, above-mentioned fast lifting device 23 can also include：Clamping screw 233, the clamping screw 233 are used for
It touches ball in spring and is loaded after structure 22 is in proper height and be locked.
Fig. 5 is the structural schematic diagram of number bubbler in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention；
Fig. 6 is the structural representation of gas flow dryer and number bubbler in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention
Figure.
Preferably, as shown in Figure 5 and Figure 6, above-mentioned several bubblers 3, which can be negative, presses bubble counter, and its counting mode can
Photoelectric counting is thought, to realize the automatic smoothness for examining micropore needle tubing.
Certainly, in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention, above-mentioned several bubblers 3 may be
Artificial counting；Its working principle is that before test is not inserted into blood with needle, make needle by aspirating air, meat under -4kPa
The bubble of " read bubble chamber " in eye observation device, with the time of 10 bubbles of stopwatch manual record, not bubbling or the excessively slow needle of bubbling
Accurately it is determined as " blocking needle ", it is impossible to be used in test.Aforesaid operations can effectively avoid the interference of invalid test data, section
Test period and blood consumption are saved.
As shown in Figure 5 and Figure 6, the moisture in order not to make humidifying enters attraction system, the intracavitary dress of dry bath of gas flow dryer 5
Enter Bibulous Silica Gel, flow through air and turned round above intracavitary silica gel in crooked route, keep it sufficiently dry, to effectively prevent moisture
In moisture be inhaled into attraction system.
It should be added that, in dressing anthemorrhagic performance in-vitro evaluation system provided in an embodiment of the present invention, it is herein
Make to protect system not by biological pollution, the front end of suction pipeline hydrophobic air filter of connecting can effectively prevent accident
Blood is sucked into attraction system.
In addition, the host panel of operation touching device 6 is equipped with start key (starting suction after touch) and timing key is used
It is appended the mouse action of computer, transparent syringe and injection needle needle stand, is able to achieve the wink for observing contacting blood to test specimen
Between hand formula touch mouse-keyboard after make instrument start meter record.
The embodiment of the present invention also provides a kind of dressing anthemorrhagic performance in-vitro evaluation method, including：Using assay balance and examination
It tests model mechanism perseverance vacuum suction measurement and flows through the blood flow reduced rate of dressing, and pass through d=(Vi-VfThe formula manipulation of)/t
Data；In formula：D --- flow-reduction, every square of second (μ g/s of microgram2)；Vi--- initial flow, microgram are (μ g/s) per second；
Vf--- final flow rate, microgram are (μ g/s) per second；T --- the time interval between initial flow and final flow rate is 30s, second
(s)。
Wherein, above-mentioned permanent vacuum suction is -4kPa ± 0.1kPa.
Dressing anthemorrhagic performance in-vitro evaluation system and method provided in an embodiment of the present invention, meet claimed below：
One, biological safety requirement：Using human oriented design, sample is easy to loading and unloading, the risk of blood test for contamination system
Within the acceptable range；The risk that injection needle is surprisingly pricked the hand is within the acceptable range；
Two, operation requires：Reliable jacking system；Host panel is equipped with start key (starting suction after touch) and counts
Shi Jian (instrument starts timing after the moment for observing contacting blood to test specimen touches)；
Three, automation requires：After timing key is opened, instrument record simultaneously runs autostop behind 90s ± 0.5, records respectively
The mass loss of preceding 30s and rear 30s, automatic display and/or print result (difference of the flow of preceding 30s and rear 30s, then divided by total
Time) simultaneously, with μ g/s2Or μ L/s2(weight counting is converted into volume reading by density of blood) is unit；
Four, vacuum suction source stability requirement：The vacuum suction of output -4kPa ± 0.5kPa；
Five, injection needle screening function requirement：An interface for the screening of injection needle gas is designed on host, can determine that injection
Whether syringe intracavity is unimpeded and/or meets test requirements document；
Six, electrical security requirement：Meet GB in 4793.1《The safety of measurement, control and laboratory's electrical installation is wanted
Seek part 1：General Requirement》.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (10)
1. a kind of dressing anthemorrhagic performance in-vitro evaluation system, which is characterized in that including：
Assay balance, the assay balance are equipped with the test model machine for measuring the blood flow reduced rate for flowing through dressing
Structure, the test model mechanism are communicated with several bubblers by suction pipeline, and the front end of the suction pipeline be serially connected with biology every
From air filter；
Gas flow dryer, the gas flow dryer becomes one with several bubblers, and the drying chamber of the gas flow dryer
It is provided with desiccant；
Touching device is operated, the operation touching device is connect with the gas flow dryer, and the operation touching device is used for
The execution of permanent vacuum suction operation；
Data processing equipment, the data processing equipment are connect with the assay balance and the operation touching device respectively, and
The data processing equipment exports result for acquiring, handling data.
2. dressing anthemorrhagic performance in-vitro evaluation system according to claim 1, which is characterized in that the test model mechanism
Including：Disposable sample holding device, the disposable sample holding device include：Blood vessel equipped with human whole blood, with
And the disposable syringe equipped with test sample or control sample；
The disposable syringe is communicated with injection needle, and the injection needle protrudes into the human whole blood in the blood vessel
In.
3. dressing anthemorrhagic performance in-vitro evaluation system according to claim 2, which is characterized in that the test model mechanism
Further include：Spring touches ball and is loaded structure, and the spring touches ball and is loaded structure for clamping the disposable syringe.
4. dressing anthemorrhagic performance in-vitro evaluation system according to claim 3, which is characterized in that the spring touches ball and is loaded
Structure includes：Be loaded ontology, and the ontology that is loaded is equipped with the holding tank for clamping the disposable syringe, described to be loaded this
Groove that is vertical with the holding tank and being connected to setting is additionally provided on body, and the groove is provided with compressed spring；
One end of the compressed spring is connect with the groove, the other end is connected with steel ball, and the steel ball and described disposable
Syringe contact setting.
5. dressing anthemorrhagic performance in-vitro evaluation system according to claim 4, which is characterized in that between on the ontology that is loaded
Every equipped with holding tank and the groove described in three groups, a pair of compressed spring and the steel are respectively arranged in groove described in every group
Ball.
6. dressing anthemorrhagic performance in-vitro evaluation system according to claim 3, which is characterized in that the test model mechanism
Further include：Fast lifting device, the fast lifting device are located at the top of the assay balance；
The fast lifting device includes：Rack gear, and with the rack gear meshed gears；The spring touch ball be loaded structure with
The gear connection, and can be moved up and down along the rack gear.
7. dressing anthemorrhagic performance in-vitro evaluation system according to claim 6, which is characterized in that the fast lifting device
Further include：Clamping screw, the clamping screw are used to touch ball in the spring and be loaded after structure is in proper height and be locked
It is fixed.
8. dressing anthemorrhagic performance in-vitro evaluation system according to claim 1, which is characterized in that several bubblers are negative pressure
Bubble counter, and counting mode is photoelectric counting.
9. a kind of dressing anthemorrhagic performance in-vitro evaluation method, which is characterized in that negative using assay balance and test model mechanism perseverance
Pressure attracts measurement to flow through the blood flow reduced rate of dressing, and passes through d=(Vi-VfThe formula manipulation data of)/t；In formula：
D --- flow-reduction, every square of second (μ g/s of microgram2)；
Vi--- initial flow, microgram are (μ g/s) per second；
Vf--- final flow rate, microgram are (μ g/s) per second；
T --- the time interval between initial flow and final flow rate is 30s, second (s).
10. dressing anthemorrhagic performance in-vitro evaluation method according to claim 9, which is characterized in that the perseverance vacuum suction
For -4kPa ± 0.1kPa.
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|---|---|---|---|
| CN201810445847.9A CN108896426B (en) | 2018-05-10 | 2018-05-10 | System and method for evaluating hemostatic performance of dressing in vitro |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810445847.9A CN108896426B (en) | 2018-05-10 | 2018-05-10 | System and method for evaluating hemostatic performance of dressing in vitro |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109974820A (en) * | 2019-03-13 | 2019-07-05 | 上海理工大学 | Pen-type insulin syringe Dose accuracy detection device and method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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