CN106344952A - Compound dressing with high liquid absorption performance and preparation method of compound dressing - Google Patents
Compound dressing with high liquid absorption performance and preparation method of compound dressing Download PDFInfo
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- CN106344952A CN106344952A CN201610593559.9A CN201610593559A CN106344952A CN 106344952 A CN106344952 A CN 106344952A CN 201610593559 A CN201610593559 A CN 201610593559A CN 106344952 A CN106344952 A CN 106344952A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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Abstract
The invention relates to compound dressing with high liquid absorption performance and a preparation method of the compound dressing. The compound dressing is prepared from chitosan serving as a raw material and consists of a supporting layer and a functional layer, wherein the supporting layer is functional nonwoven cloth; the functional layer is prepared by performing water dissolving, macromolecular crosslinking, foaming, freeze drying and the like on carboxymethyl chitosan. The compound dressing is high in mechanical property and pore-forming property; furthermore, by the compound design of a dual-layer structure, the liquid absorption performance is higher than that of common dressing, and the compound dressing is suitable for perpendicular absorption application. Chitosan is a natural macromolecular polymer and belongs to aminopolysaccharide, so that the dressing is high in mechanical property, high in seepage absorption, and also high in biological compatibility, degradability and nontoxicity, can induce tissue regeneration and remodeling, can effectively promote healing of a wound, and is a more ideal healing promotion material.
Description
Technical field
The invention belongs to medical instruments field, it is related to a kind of combine dressing and its production technology, particularly to one kind with shell
Polysaccharide and cotton polysaccharide non-woven fabrics are raw material, prepare the bio-medical being suitable to tissue repair that mechanical strength is high, have high liquid-absorbing
Material, described dressing is adapted to burn wound, wound and wound surface, chronic ulcer, bedsore wound, infective wound surface, surgical wound surface
Covering treatment.
Background technology
Medical dressing is the temporary transient class clinical medical material covering the wounds such as burn, ulcer, wound, and it is mainly made
With being the transudate of control wound and protecting the wound from the pollution of the external sources such as antibacterial and grit.With modern life rhythm accelerate and
The continuous growth of requirements of health care, the demand of medical dressing is also increasing year by year, and in the world, conventional medical is applied
Material still accounts for more than the 50% of whole medical dressing at present, but global medical dressing also shows that conventional medical dressing growth becomes simultaneously
Slow, and high performance functionality wound dressing is put forward higher requirement.In recent years, people are additional to multi-functional, plastics on new materials, height
The demand of value medical dressing is more and more urgent, and Medical dressing can shorten wound healing time, reduces medical dressing consumption,
The notable shortening nursing time, cater to patient requests.Medical dressing curative effect is fast, effect is that traditional dressing is difficult to compare the features such as good
Intend, therefore, novel medical dressing will have bigger application market.
In recent years, chitin and chitosan has attracted increasing attention in the application of technical field of biological material, applies in wound
Material, medical absorbable suture, sustained-release drug carrier, enzyme fix, coagulant and anticoagulant, appetrol, anticarcinogen, ophthalmology material
The application in the fields such as material has research, or even some study commercialization.And shitosan is due to having unique and excellent life
Reason activity, the research in terms of wound dressing is increasingly becoming it in one of biomaterial applied research focus.
Ueno etc. shows that the shitosan of bulk multi-hole mainly can pass through to promote polymorphonuclear leukocyte with accelerating wound healing
In the infiltration of wound site, this be quick wound healing necessary process (biomaterials, 1999,20 (15): 1407-
1414).Recently, the report such as mizuno shitosan is good wound repair material, is compounded with basic fibroblastic growth
The shitosan of the factor (bfgf) can be with healing acceleration speed (journal of biomedical materialsresearch
Part a, 2003,64a (1): 177-181.).Shitosan usually faces several difficult problems as dressing in terms of preparation, such as dissolves
Property, absorbency, biocidal property, comfortableness etc., although some patents present some achievements in research, as scale production process
Obviously require study, such as in Chinese patent cn 101816802 a, be prepared for a kind of chitosan-based medical dressing, but due to it
The film that formed more crisp, mechanical property is bad, generally requires by improving its mechanical property with other materials blending；Invention is specially
Sharp cn1431021a discloses a kind of chitosan-collagen sponge for gynaecopathia, uses hydrochloric acid or acetic acid in its preparation technology
Deng acid leach solution shitosan, wherein adopt acid solution, easily environment is had undesirable effect, and need secondary vacuum to freeze
It is dried, increase cost；Patent of invention cn105477679 a discloses a kind of shitosan quick-acting haemostatic powder cotton crosslinked based on polysaccharide
Preparation method, this patent is used chitosan hydrochlorate as primary raw material, and biocompatibility is poor compared with carboxymethyl chitosan, so only
Can use as hemostatic material.
Accordingly, it would be desirable to overcome the problems referred to above of the prior art, develop a kind of good mechanical performance, absorb sepage ability
Height is to be suitable for the bio-medical dressing having a large amount of sepage wounds in clinic.
Content of the invention
It is contemplated that abandoning the traditional handicraft complicated with step using a large amount of reagent, provide a kind of simple effective method
Obtain mandruka dressing, its structural homogeneity is good, it is strong to absorb sepage ability.
Another object of the present invention there are provided a kind of combine dressing with high liquid-absorbing energy and preparation method thereof, and it is special
Levy and be to comprise the following steps:
1. a kind of combine dressing with high liquid-absorbing energy and preparation method thereof is it is characterised in that it is by chitosan sponge material
Material is non-woven fabric compounded with polysaccharide to be formed, and described preparation method comprises the following steps:
1) step preparing carboxymethyl chitosan solution, described step is to prepare macromolecules cross-linking material first, that is, it is suitable to prepare
The sodium alginate aqueous solution of concentration, is then slowly added to mechanical agitation in sodium periodate solution, then deionized water dialysis 24 ~
48h, vacuum freeze carries out lyophilization to reactant liquor, and cooling time is 24h, and drying time is 48 ~ 72h.Second
Step is to prepare the carboxymethyl chitosan solution of certain mass, is subsequently adding macromolecules cross-linking material and the qs glycerin of above-mentioned preparation
Mix homogeneously reacts 10 ~ 90min, is eventually adding surfactant, high-speed stirred 30-90 min；
2) step preparing combine dressing, described step is that functional non-woven fabric is fixed on the bottom of coating machine, above-mentioned obtains
Carboxymethyl chitosan solution pour in non-woven fabrics upper end, setting different coating height, carry out composite coating, the material after being combined
Carry out lyophilization, cooling time is 24h, drying time is 48 ~ 72h；
3) step of dressing curing molding, after vacuum drying, carries out cured, moves into drying baker or hyperpyrexia container to dressing
Carry out continuous high temperature process, obtain final combine dressing.
2. preparation method according to claim 1 is it is characterised in that described macromolecules cross-linking material is Sargassum
Sour sodium, potato starch, tapioca, glucose, dopamine, hyaluronic acid；Described sodium alginate aqueous solution and periodic acid
Sodium volume ratio is 1 ~ 10:1；The ratio of the glycerol of described addition is the mass ratio that 20% ~ 80%(is with respect to shitosan), mixing is stirred
The time mixed is 10 ~ 90min；Described carboxymethyl chitosan solution mass fraction is 0.01-20%.
3. preparation method according to claim 1 is it is characterised in that carboxymethyl chitosan solution is handed over macromole
Connection material mass ratio is for 5 ~ 50:1.
4. preparation method according to claim 1 is it is characterised in that described surfactant is poloxamer
407.
5. preparation method according to claim 1 is it is characterised in that carboxymethyl chitosan solution and surface activity
Agent mass ratio is 1 ~ 10:1.
6. preparation method according to claim 1 is it is characterised in that composite material base is chosen as cotton polysaccharide no
Spin cloth, calcium alginate non-woven fabrics, shitosan non-woven fabrics, regenerated fiber non-woven fabrics, vinal non-woven fabrics, ester fiber of birdsing of the same feather flock together
Non-woven fabrics.
7. preparation method according to claim 1 is it is characterised in that the temperature of combine dressing heat treatment is 30 ~ 80
DEG C, preferably 60 DEG C, hardening time is 12 ~ 96h.
8. preparation method according to claim 1 is it is characterised in that described combine dressing functional layer (coating layer)
Thickness is 1 ~ 10；The aperture of described spongy layer is 200～400 μm, and porosity is more than 80%.
Because technique scheme is used, the present invention devises and prepares mechanics with carboxymethyl chitosan and cotton polysaccharide for raw material
Performance and the good compound dressing of absorbency, at least have the advantage that
1. crosslinking is carried out using macromolecular complex confrontation sponge structure, instead of small molecule toxic chemical (as formaldehyde, penta 2
Aldehyde etc.) use, there is more preferable histocompatibility；
2. we prepare porous material with the high-speed stirred of surfactant and polysaccharide, and not only product structure is uniform, porosity
High it is often more important that, the design of this structure drastically increases the ability that this dressing absorbs sepage, has wide range of applications, is expected to
The wound healing that a variety of causes leads to is promoted to grow with promoting granulation；
3. porous stent structure and the composite design of non-woven fabrics base material, not only extend mechanical property and the structural strength of dressing,
And be not in adhesion and residual condition with wound during the use of wound, dramatically reduce the misery of patient；
4. the controllability of this process very well, can promote traditional medicine, medical device industry to high-new for mark with biotechnology
Technology develops rapidly.Meet the requirement of China's Resources for construction economizing type and friendly environment society, social benefit is notable.
Brief description
Table 1 is that embodiment 1 dressing pastes liquid-absorbent synopsis with chitosan dressing.
Fig. 1 is the microcosmic loose structure of the cotton polysaccharide/shitosan combine dressing of preparation in embodiment 2.
Table 2 is that embodiment 3 has the cotton polysaccharide/shitosan combine dressing of biocidal property and the contrast of gauze bacteriostasis rate.
Specific embodiment
The invention will be further described for (table) and embodiment below in conjunction with the accompanying drawings:
Embodiment 1:
Weigh 1.0 g sodium alginates to be dissolved in 140 ml water, thereto Deca 10 ml sodium periodate solution (40 mg/ml), often
Warm electromagnetic agitation is reacted 4 hours.Deca 0.200 ml ethylene glycol thereto again, stirring reaction is after 1 hour, then with retention molecule
The bag filter leaching of amount 3500 is dialysed 24 hours in deionized water, and every 4 hours of period changed a water, vacuum equipment lyophilization 48
Hour, obtain the sodium alginate solid of hydroformylation.
Weigh 1.0 g carboxymethyl chitosans again to be dissolved in 30 ml water, during need ultrasonic or stirring and dissolving about 30min,
It is formulated as follows solution at the same time: the sodium alginate of the above-mentioned hydroformylation of 50 mg is dissolved in 10 ml water；1.50 g glycerol are dissolved in 1 ml
In water, 0.30 g Poloxamer 407 is dissolved in 9 ml water and 10 ml pbs.Next, the glycerol after preparing is added carboxymethyl
In chitosan solution, stir 10min, then the sodium alginate soln after Deca dissolving, stirring reaction 30min.Lip river finally will be moored
Husky nurse 407 solution adds in above-mentioned reactant liquor, high-speed stirred 60min.
Cotton polysaccharide non-woven fabrics are fixed on coating motor spindle, then the thick liquid that above-mentioned high-speed stirred is obtained pours into no
Spin cloth upper end, setting coating height 2mm, carry out composite coating, the material after being combined carries out lyophilization, cooling time is 24h,
Drying time is 48h, after vacuum drying, moves into drying baker and 48h is dried, obtain final cotton polysaccharide/shitosan combine dressing.Will
This dressing does liquid-absorbent contrast test with chitosan dressing patch, the results are shown in Table 1.
Embodiment 2:
Weigh 1.5g starch to be dissolved in 150 ml water, thereto Deca 10 ml sodium periodate solution (80 mg/ml), room temperature electromagnetism
Stirring reaction 2 hours.Deca 0.40 ml ethylene glycol thereto again, then after reacting 1 hour, then use molecular cut off 3500
Bag filter leaching is dialysed 24 hours in deionized water, and every 4 hours of period changed a water, vacuum equipment lyophilization 48 hours, obtained
To hydroformylation starch.
Weigh 2.0 g carboxymethyl chitosans again to be dissolved in 60 ml water, during need ultrasonic or stirring and dissolving about 30min,
It is formulated as follows solution at the same time: the starch of the above-mentioned hydroformylation of 100 mg is dissolved in 20 ml water；1.5 g glycerol are dissolved in 2 ml water,
0.60 g Poloxamer 407 is dissolved in 20 ml water.Next, adding the glycerol after preparing in carboxymethyl chitosan solution, stir
Mix 10min, then the sodium alginate soln after Deca dissolving, stirring reaction 30min.Finally Poloxamer 407 solution is added
In above-mentioned reactant liquor, high-speed stirred 60min.
Chitosan polysaccharide non-woven fabrics are fixed on coating motor spindle, then the thick liquid that above-mentioned high-speed stirred is obtained pours into
In non-woven fabrics upper end, setting coating height 5mm, carry out composite coating, the material after being combined carries out lyophilization, and cooling time is
24h, drying time is 48h, after vacuum drying, moves into drying baker and 48h is dried, obtain final cotton polysaccharide/shitosan compound deposited
Material.
Referring to accompanying drawing 1, it is the scanning repairing plug according to the fibroin albumen/gelatin porous anal fistula of technique scheme preparation
Electron microscope.It can thus be seen that material defines good loose structure, bore dia is between 200-400 μm.
Embodiment 3:
Macromolecules cross-linking material prepare method same as Example 1.
Weigh 2.40 g carboxymethyl chitosans to be dissolved in 110 ml water, 120 mg hydroformylation sodium alginates are dissolved in 20 ml water,
3.0 g glycerol are dissolved in 2 ml water, and 0.60 g Poloxamer 407 is dissolved in 38 ml water, and the quaternized pei of 12 mg is dissolved in 10 ml
In water.Glycerol is added in above-mentioned chitosan solution, stirs 5min.Pei solution is added in above-mentioned chitosan solution, stirring
15min.Then sodium alginate soln Deca is entered in chitosan solution, stir 25min.Poloxamer solution is added shitosan
In solution, high-speed stirred 60min.
Cotton polysaccharide spinning cloth is fixed on coating motor spindle, then the liquid that above-mentioned high-speed stirred is obtained pours on non-woven fabrics
End, setting coating height 5mm, carry out composite coating, the material after being combined carries out lyophilization, cooling time is 24h, when being dried
Between be 48h, after vacuum drying, move into drying baker and 24h be dried, obtain the final cotton polysaccharide/shitosan with biocidal property and be combined
Dressing.
Bacteriostatic test detects:
Detection is Candida albicans atcc 10231 and staphylococcus aureus atcc6538 with bacterium.Gauze and above-mentioned there is biocidal property
Cotton polysaccharide/shitosan combine dressing take the sample of 1 × 1 cm to be placed in different culture dishs respectively.Strain is sought with 1/500
Foster broth dilution becomes the bacteria suspension of debita spissitudo standby.The bacteria suspension taking 0.1 ml is added in every group of material.At 35 DEG C, relatively
Humidity cultivates 24 h under conditions of being not less than 90%.Rinse sample with the phosphate buffered saline of 5 ml, then respectively take 0.1
Ml coats on culture medium flat plate, cultivates 24 h at 35 DEG C, and observed result is shown in Table 2.
Embodiment 4:
Macromolecules cross-linking material prepare method same as Example 1.
Weigh 3.00 g chitosan hydrochlorate to be dissolved in 28 ml tris hcl buffer, stir 20 min, assume Huang
Color thick liquid.Weigh 1.50 g glycerol again, with 1 ml tris hcl buffer solution.Weigh 0.30 g Poloxamer 407
It is dissolved in 20 ml tris hcl buffer, stirring is until being completely dissolved.Weigh 0.20 g dopamine hydrochloride, be added to
In the Poloxamer solution having dissolved.Glycerol and dopamine solution are added in chitosan hydrochlorate solution, high-speed stirring
Mix 30 min.Weigh 0.02 sodium metaperiodate, with 1 ml tris hcl buffer solution.Sodium periodate solution is added to
State in solution, continue stirring 15 min.
Shitosan non-woven fabrics are fixed on coating motor spindle, then the thick liquid that above-mentioned high-speed stirred is obtained pours into no
Spin cloth upper end, setting coating height 2mm, carry out composite coating, the material after being combined carries out lyophilization, cooling time is 24h,
Drying time is 48h, after vacuum drying, moves into drying baker and 24h is dried, obtain final shitosan/shitosan combine dressing.
Table 1: dressing pastes liquid-absorbent synopsis with chitosan dressing
| Sample ID | Initial mass (mg) | Quality (mg)/liquid absorbency rate after imbibition 1min | Quality (mg)/liquid absorbency rate after imbibition 30min | Quality (mg)/liquid absorbency rate after imbibition 60min |
| Shitosan is applied ointment or plaster | 16 | 224/14 | 372/23.3 | 376/23.5 |
| Combine dressing | 16 | 454/28.4 | 707/44.2 | 1060/66.2 |
Table 2: bacteriostatic test
| Sample ID | Candida albicans sterilizing rate | Staphylococcus aureus sterilizing rate |
| Gauze | 0 | 0 |
| Compound dressing | 94 | 96 |
Claims (8)
1. a kind of combine dressing with high liquid-absorbing energy and preparation method thereof is it is characterised in that it is by chitosan sponge material
Material is non-woven fabric compounded with polysaccharide to be formed, and described preparation method comprises the following steps:
1) step preparing carboxymethyl chitosan solution, described step is to prepare macromolecules cross-linking material first, that is, it is suitable to prepare
The sodium alginate aqueous solution of concentration, is then slowly added to mechanical agitation in sodium periodate solution, then deionized water dialysis 24 ~
48h, vacuum freeze carries out lyophilization to reactant liquor, and cooling time is 24h, and drying time is 48 ~ 72h, and second
Step is to prepare the carboxymethyl chitosan solution of certain mass, is subsequently adding macromolecules cross-linking material and the qs glycerin of above-mentioned preparation
Mix homogeneously reacts 10 ~ 90min, is eventually adding surfactant, high-speed stirred 30-90 min；
2) step preparing combine dressing, described step is that functional non-woven fabric is fixed on the bottom of coating machine, above-mentioned obtains
Carboxymethyl chitosan solution pour in non-woven fabrics upper end, setting different coating height, carry out composite coating, the material after being combined
Carry out lyophilization, cooling time is 24h, drying time is 48 ~ 72h；
3) step of dressing curing molding, after vacuum drying, carries out cured, moves into drying baker or hyperpyrexia container to dressing
Carry out continuous high temperature process, obtain final combine dressing.
2. preparation method according to claim 1 it is characterised in that described macromolecules cross-linking material be sodium alginate,
Potato starch, tapioca, glucose, dopamine, hyaluronic acid；Described sodium alginate aqueous solution and sodium metaperiodate volume
Than for 1 ~ 10:1；The ratio of the glycerol of described addition be 20% ~ 80%(with respect to shitosan mass ratio), mix and blend when
Between be 10 ~ 90min；Described carboxymethyl chitosan solution mass fraction is 0.01-20%.
3. preparation method according to claim 1 is it is characterised in that carboxymethyl chitosan solution and macromolecules cross-linking material
Mass ratio is 5 ~ 50:1.
4. preparation method according to claim 1 is it is characterised in that described surfactant is Poloxamer 407.
5. preparation method according to claim 1 is it is characterised in that carboxymethyl chitosan solution and surfactant qualities
Than for 1 ~ 10:1.
6. preparation method according to claim 1 it is characterised in that composite material base be chosen as cotton polysaccharide non-woven fabrics,
Calcium alginate non-woven fabrics, shitosan non-woven fabrics, regenerated fiber non-woven fabrics, vinal non-woven fabrics, kind polyester fiber non-woven
Cloth.
7. preparation method according to claim 1 is it is characterised in that the temperature of combine dressing heat treatment is 30 ~ 80 DEG C, excellent
Elect 60 DEG C as, hardening time is 12 ~ 96h.
8. preparation method according to claim 1 is it is characterised in that the thickness of described combine dressing functional layer (coating layer)
For 1 ~ 10；The aperture of described spongy layer is 200～400 μm, and porosity is more than 80%.
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Cited By (9)
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| CN107088236A (en) * | 2017-03-31 | 2017-08-25 | 北京化工大学 | A kind of preparation method of enhanced antibacterial anti hemorrhagic bio-sponge |
| CN108066811A (en) * | 2017-12-29 | 2018-05-25 | 广州润虹医药科技股份有限公司 | A kind of medical compound hemostatic sponge of negative pressure drainage and preparation method thereof |
| CN108896426A (en) * | 2018-05-10 | 2018-11-27 | 山东省医疗器械产品质量检验中心 | Dressing anthemorrhagic performance in-vitro evaluation system and method |
| CN109453417A (en) * | 2018-10-08 | 2019-03-12 | 中国海洋大学 | A kind of polysaccharide burn dressing and its preparation method and application |
| CN110628075A (en) * | 2019-09-27 | 2019-12-31 | 杭州电子科技大学 | Chitosan porous functional layer of a dust-proof antibacterial mask and preparation method thereof |
| CN110694102A (en) * | 2019-11-13 | 2020-01-17 | 中国矿业大学 | A 3D printed hydrogel wound dressing with long-lasting antibacterial effect |
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| CN114681654A (en) * | 2020-12-31 | 2022-07-01 | 广州迈普再生医学科技股份有限公司 | Absorbable sponge dressing with wound repair function and preparation method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107088236A (en) * | 2017-03-31 | 2017-08-25 | 北京化工大学 | A kind of preparation method of enhanced antibacterial anti hemorrhagic bio-sponge |
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| CN108896426A (en) * | 2018-05-10 | 2018-11-27 | 山东省医疗器械产品质量检验中心 | Dressing anthemorrhagic performance in-vitro evaluation system and method |
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| CN109453417A (en) * | 2018-10-08 | 2019-03-12 | 中国海洋大学 | A kind of polysaccharide burn dressing and its preparation method and application |
| CN110628075A (en) * | 2019-09-27 | 2019-12-31 | 杭州电子科技大学 | Chitosan porous functional layer of a dust-proof antibacterial mask and preparation method thereof |
| CN110694102A (en) * | 2019-11-13 | 2020-01-17 | 中国矿业大学 | A 3D printed hydrogel wound dressing with long-lasting antibacterial effect |
| CN114681654A (en) * | 2020-12-31 | 2022-07-01 | 广州迈普再生医学科技股份有限公司 | Absorbable sponge dressing with wound repair function and preparation method thereof |
| CN114681654B (en) * | 2020-12-31 | 2023-04-18 | 广州迈普再生医学科技股份有限公司 | Absorbable sponge dressing with wound repair function and preparation method thereof |
| CN113429622A (en) * | 2021-06-28 | 2021-09-24 | 万华化学集团股份有限公司 | Method for rapidly preparing double-layer structure foam with low residual monomer content, foam material and application thereof |
| CN114344549A (en) * | 2021-12-13 | 2022-04-15 | 动之医学技术(上海)有限公司 | Composite amnion dressing and preparation method thereof |
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