CN201429621Y - Fully automatic sampling instrument - Google Patents
Fully automatic sampling instrument Download PDFInfo
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- CN201429621Y CN201429621Y CN2009200728672U CN200920072867U CN201429621Y CN 201429621 Y CN201429621 Y CN 201429621Y CN 2009200728672 U CN2009200728672 U CN 2009200728672U CN 200920072867 U CN200920072867 U CN 200920072867U CN 201429621 Y CN201429621 Y CN 201429621Y
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Abstract
The utility model discloses a fully automatic sampling instrument which comprises a pressure sensor and a signal conditioning circuit connected with the pressure sensor. The signal conditioning circuit is also connected with a liquid level detection unit, an air bubble detection unit, a fibrous protein detection unit and a controller. The air bubble detection unit, the fibrous protein detection unit and the controller are respectively used for acquiring and analyzing the data of various test items to accurately transmit an executive instruction for the signal of the controller. After the signal is detected by the pressure sensor and amplified by the signal conditioning circuit, all the units judge whether a suction head is in contact with a liquid level, enters air bubble, and sucks fibrous protein, and then relevant signals are transmitted to the controller; and the controller can implement the corresponding executive instruction according to the different signals.
Description
Technical field
The utility model relates to a kind of be used for distributing automatically serum and the full-automatic application of sample instrument of reagent, is widely used in clinical laboratory, biology laboratory, visiting center, blood station etc.
Background technology
For the application of sample instrument, move liquid accuracy and institute and add the key that the liquid correctness is an assurance application of sample quality.In sampling, application of sample process, must finish level detection, bubble detection and fibrin and detect.Has only the reliability that complete level detection, bubble detect, fibrin detects the correct and assay that may guarantee that just liquid distributes.In level detection,, will cause the suction nozzle outside that serious extension liquid is arranged, thereby make experimental precision out of control if level detection is inaccurate or do not detect liquid level directly from bottom suction sample.Bubble in blood or the reagent also has material impact to experiment, if when sampling bubble as effective liquid level, then air is used as liquid and is added in the reaction system, thereby cause the experimental result mistake.Fibrin in the imbibition process in the serum blocks suction nozzle can influence experiment effect equally, makes experimental result inaccurate thereby fibrin can completely or partially block suction nozzle.
The suction nozzle of application of sample instrument has following two kinds in the prior art, but respectively has defective:
A) use the conduction suction nozzle,, thereby can detect liquid level if suction nozzle touched suction nozzle as the liquid in the conductor container then resistance or electricity are led and changed.
The major defect of this method is: conduction suction nozzle cost is several times of common suction nozzle; Can't detection fibers albumen and detection non-electrically conductive liquid.
B) use stainless pin to carry out application of sample, change and detect liquid level, bubble, fibrin by touching behind the liquid electric capacity
The major defect of this method is: contact is moved liquid, can't get rid of the problem of cross pollution fully; Need complicated cleaning procedure, influence liquid feeding speed; The system cost height needs extra pump and washing fluid; Complex operation, the user need prepare and change washing fluid.
China's application 200610026040.9 discloses a kind of like this micro-sampling pump, adopts disposable common suction nozzle, can not only realize the contactless liquid that moves, and gets rid of the problem of cross pollution fully; Do not need simultaneously complicated cleaning procedure, liquid feeding speed is fast; And system cost is low, does not need extra pump and washing fluid.Common suction nozzle use cost is low, but also detection fibers albumen and non-electrically conductive liquid.
Owing to adopt disposable tip, after suction nozzle is loaded onto, take detection at quarter suction nozzle and whether closely cooperate; After having sampled, need suction nozzle is destroyed.Therefore on the suction nozzle (specifically in application of sample instrument pump body, piston-cylinder or rifle head position) micro-pressure sensor is set, cooperate signal conditioning circuit, change and whether to cooperate closely by the sensitive suction nozzle of surveying liquid level and being enclosed within on the rifle head according to inner pressure of air cylinder.
The utility model content
Problem to be solved in the utility model provides a kind of full-automatic application of sample instrument, can carry out level detection, bubble detection and fibrin automatically and detect, and guarantee the accuracy of detection.
The utility model is by the following technical solutions:
A kind of full-automatic application of sample instrument comprises the signal conditioning circuit that pressure transducer is connected with pressure transducer, and signal conditioning circuit also is connected with controller with level detection unit, bubble detecting unit, fibrin detecting unit.
The utility model is established level detection unit, bubble detecting unit and fibrin detecting unit, is responsible for the data acquisition and the analysis of every test item respectively, sends execution command to give the accurate signal of controller.After pressure transducer detects signal, after signal conditioning circuit amplifies, whether touched liquid level, whether enter bubble, whether sucked fibrin by each unit judges suction nozzle, then coherent signal is imported into controller, controller can be made corresponding execution command according to unlike signal.
The utility model carries out difference in functionality by three detecting units and detects, and makes to detect completely, and the coordination by controller and each unit can automatically just be operated, and need not human intervention.Can guarantee sampling quality, raise the efficiency again.
Further, described level detection unit, bubble detecting unit, fibrin detecting unit are connected with the abnormal conditions processing unit respectively, and the abnormal conditions processing unit is connected with controller.
Preferably, described level detection unit is provided with data-carrier store.
Preferably, described bubble detecting unit is provided with data-carrier store.
Description of drawings
Fig. 1 is that the system of full-automatic application of sample instrument constitutes synoptic diagram
Embodiment
See Fig. 1, full-automatic application of sample instrument comprises pressure transducer, signal conditioning circuit, level detection unit, bubble detecting unit, fibrin detecting unit and the controller that is connected.Controller also is connected with the topworks of application of sample instrument, with the motion of control suction nozzle.Wherein level detection unit, bubble detecting unit, fibrin detecting unit, controller are connected with the abnormal conditions processing unit respectively, when detecting abnormal conditions, the abnormal conditions processing unit can relevant information be sent in each unit, sends dependent instruction by this unit to controller.Level detection unit and bubble detecting unit all are provided with data-carrier store in addition, compare with deposit data and detection signal.
What pressure transducer detected is that the interior pressure of cylinder changes, it is relevant with the pressure variation of suction nozzle head that this parameter changes, the signal that signal conditioning circuit is responsible for pressure transducer is recorded amplifies, in suction nozzle moves downward, before can experience touching liquid level, enter liquid level, in liquid level, draw three processes of sample liquid, the corresponding respectively unit module of level detection unit, bubble detecting unit and these three different measuring abilities of fibrin detecting unit.Can only reflect the suction nozzle state indirectly because pressure transducer detects, and which process need suction nozzle enters by judging each unit, employing is analyzed in each unit based on detection principle is also different, and is specific as follows:
When suction nozzle and liquid-transfering gun moved downward together, the pressure of detected pressures sensor changed in real time, and threshold values is set in the level detection unit, changed being no more than the setting threshold values as pressure, showed not detect liquid level; Change as pressure and to surpass threshold values, pre-deposit data in the data and curves of gathering and the data-carrier store is compared, be effective liquid level or run into foreign matter such as test tube rack thereby distinguish.As detect suction nozzle and be in effective liquid level, data are sent into next bubble detecting unit; Meet other objects as suction nozzle, then relevant information is sent into the abnormal conditions processing unit earlier, by this unit notification controller, the controller command execution unit is packed up suction nozzle again, seeks pan position down again.
After definite suction nozzle touches effective liquid level, compare continuing the data and curves of detected pressures sensor variation and the pre-deposit data in the data-carrier store in the bubble detecting unit, when pressure curve is identical with bubble, be reported as and detect bubble, relevant information is sent into the abnormal conditions processing unit earlier, again by this unit notification controller, the controller command execution unit is packed up suction nozzle, seeks pan position down again.As not being bubble, after then suction nozzle enters into the liquid level certain distance, can begin the imbibition sampling.
The change curve of detected pressures when inhaling sample, the mouth resistance of suction nozzle increases when being drawn onto fibrin (fibrin in the serum is generally filiform), and the thick more then resistance of fibrin is big more, thus the pressure of pressure transducer changes also more greatly.By the analysis to pressure sensor data, the fibrin detecting unit is provided with suitable threshold values, and can effectively distinguish in normal imbibition and the serum has fibrin.Normal as imbibition, then wait suck after, controller control suction nozzle rises and leaves liquid level; As detected fibrin, and relevant information is sent into the abnormal conditions processing unit earlier, again by this unit notification controller, order stops imbibition.
The utility model is established level detection unit, bubble detecting unit, fibrin detecting unit, is responsible for the data acquisition and the analysis of every test item respectively, sends execution command to give the accurate signal of controller.The abnormal conditions processing unit then is responsible for gathering rub-out signal.After pressure transducer detects signal, after signal conditioning circuit amplifies, whether touch liquid level, whether enter bubble, whether suck fibrin by each unit judges suction nozzle, if run into liquid level, bubble and suction fibrin, then directly enter controller and send the sampling instruction, if not, then coherent signal being imported into controller, controller can be made corresponding execution command according to unlike signal.
The utility model carries out difference in functionality by three detecting units and detects, and makes to detect completely, and the coordination by controller and each unit can automatically just be operated, and need not human intervention.Can guarantee sampling quality, raise the efficiency again.
Claims (4)
1. a full-automatic application of sample instrument comprises the signal conditioning circuit that pressure transducer is connected with pressure transducer, it is characterized in that: signal conditioning circuit also is connected with controller with level detection unit, bubble detecting unit, fibrin detecting unit.
2. full-automatic application of sample instrument according to claim 1 is characterized in that: described level detection unit, bubble detecting unit, fibrin detecting unit are connected with the abnormal conditions processing unit respectively, and the abnormal conditions processing unit is connected with controller.
3. full-automatic application of sample instrument according to claim 1 is characterized in that: described level detection unit is provided with data-carrier store.
4. full-automatic application of sample instrument according to claim 1 is characterized in that: described bubble detecting unit is provided with data-carrier store.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200728672U CN201429621Y (en) | 2009-05-25 | 2009-05-25 | Fully automatic sampling instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009200728672U CN201429621Y (en) | 2009-05-25 | 2009-05-25 | Fully automatic sampling instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201429621Y true CN201429621Y (en) | 2010-03-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009200728672U Expired - Fee Related CN201429621Y (en) | 2009-05-25 | 2009-05-25 | Fully automatic sampling instrument |
Country Status (1)
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| CN (1) | CN201429621Y (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101881706A (en) * | 2010-07-05 | 2010-11-10 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling device and method |
| CN102539802A (en) * | 2011-12-30 | 2012-07-04 | 北京信息科技大学 | Micropipette detection system and method |
| CN103185622A (en) * | 2013-01-18 | 2013-07-03 | 厦门优迈科医学仪器有限公司 | Liquid loading device and control method thereof |
| CN104237549A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Sample injection needle for chemiluminescence immunoassay analyzer |
| CN110926566A (en) * | 2018-09-20 | 2020-03-27 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection method, sample analyzer and computer storage medium |
| CN113717852A (en) * | 2021-09-03 | 2021-11-30 | 重庆市盛佰昱科技有限公司 | Liquid suction method and liquid feeding method for biological tissue culture solution |
| CN114112513A (en) * | 2020-08-28 | 2022-03-01 | 深圳市帝迈生物技术有限公司 | Liquid level detection method, blood analysis device and storage medium |
-
2009
- 2009-05-25 CN CN2009200728672U patent/CN201429621Y/en not_active Expired - Fee Related
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101881706A (en) * | 2010-07-05 | 2010-11-10 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling device and method |
| CN101881706B (en) * | 2010-07-05 | 2014-04-02 | 深圳迈瑞生物医疗电子股份有限公司 | Sampling device and method |
| CN102539802A (en) * | 2011-12-30 | 2012-07-04 | 北京信息科技大学 | Micropipette detection system and method |
| CN102539802B (en) * | 2011-12-30 | 2013-07-31 | 北京信息科技大学 | Micropipette detection method |
| CN103185622A (en) * | 2013-01-18 | 2013-07-03 | 厦门优迈科医学仪器有限公司 | Liquid loading device and control method thereof |
| CN103185622B (en) * | 2013-01-18 | 2017-04-12 | 厦门优迈科医学仪器有限公司 | Liquid loading device and control method thereof |
| CN104237549A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Sample injection needle for chemiluminescence immunoassay analyzer |
| CN110926566A (en) * | 2018-09-20 | 2020-03-27 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid level detection method, sample analyzer and computer storage medium |
| CN114112513A (en) * | 2020-08-28 | 2022-03-01 | 深圳市帝迈生物技术有限公司 | Liquid level detection method, blood analysis device and storage medium |
| CN113717852A (en) * | 2021-09-03 | 2021-11-30 | 重庆市盛佰昱科技有限公司 | Liquid suction method and liquid feeding method for biological tissue culture solution |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: JIAXING QUEST LIFE SCIENCE CO., LTD. Free format text: FORMER OWNER: SHANGHAI KAISHI BIOTECHNOLOGY CO., LTD. Effective date: 20121127 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 200433 YANGPU, SHANGHAI TO: 314006 JIAXING, ZHEJIANG PROVINCE |
|
| TR01 | Transfer of patent right |
Effective date of registration: 20121127 Address after: Jiaxing City, Zhejiang province 314006 Ling Gong Tang Road No. 3339, building six, floor 3 Patentee after: Jiaxing Quest Life Science Co., Ltd. Address before: 200433 room 7009A, building 1, No. 335, National Road, Shanghai, Yangpu District Patentee before: Shanghai Kaishi Biotechnology Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20100324 Termination date: 20170525 |