CN102539802A - Micropipette detection system and method - Google Patents
Micropipette detection system and method Download PDFInfo
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- CN102539802A CN102539802A CN2011104512768A CN201110451276A CN102539802A CN 102539802 A CN102539802 A CN 102539802A CN 2011104512768 A CN2011104512768 A CN 2011104512768A CN 201110451276 A CN201110451276 A CN 201110451276A CN 102539802 A CN102539802 A CN 102539802A
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Abstract
本发明涉及一种微量移液探测系统及方法，其中系统包括：加样枪枪体；设置在所述加样枪枪体内的压力传感器，用于对所述加样枪枪体体内的气体压力状况进行实时监测，在所述加样枪枪体所在的多通道移液系统的吸液过程中获取所述加样枪枪体内的实时压强值；第一获取模块，用于在所述吸液过程中根据所述压力传感器获取到的实时压强值获取所述加样枪枪体内的监测结果；第一确定模块，用于根据所述监测结果与预设的多个压强曲线确定所述加样枪枪体所在的多通道移液系统所处的状态。本发明实施例提供的微量移液探测系统及方法，通过采用压力传感器实现对加样枪枪体内的压力液面探测和吸液过程监控，提高了加样过程的精度和灵敏性，从而避免了多通道移液系统的液体的交叉污染。
The present invention relates to a micro-pipetting detection system and method, wherein the system includes: a gun body of a sampling gun; a pressure sensor arranged in the gun body of the sampling gun, which is used to measure the gas pressure in the gun body of the sampling gun The situation is monitored in real time, and the real-time pressure value in the body of the sample gun body is obtained during the liquid absorption process of the multi-channel pipetting system where the sample body is located; the first acquisition module is used for In the process, according to the real-time pressure value obtained by the pressure sensor, the monitoring result in the gun body of the sampling gun is obtained; the first determination module is used to determine the sampling according to the monitoring result and a plurality of preset pressure curves. The state of the multichannel pipetting system where the gun body is located. The micro-pipetting detection system and method provided by the embodiments of the present invention realize the detection of the pressure liquid level in the gun body of the sampling gun and the monitoring of the liquid absorption process by using the pressure sensor, which improves the accuracy and sensitivity of the sampling process, thereby avoiding the Cross-contamination of liquids in multichannel pipetting systems.
Description
Technical field
The present invention relates to the Technology of Precision Measurement field, particularly a kind of micropipette detection system and method.
Background technology
It is a kind of immune analysis method that enzyme exempts to analyze (Enzyme Linked Immunosorbent Assay abbreviates ELISA as), is based on antigen-antibody and combines, and has enzyme immunological characteristic and high efficiency.The ELISA checkout procedure comprises: application of sample, wash plate, incubation, read plate etc.Wherein, application of sample is meant that the hyperchannel liquor-transferring system transfers to another container with a spot of liquid from a container, promptly after the source container imbibition, moves and is assigned in the target container.At definite Interventions Requested (for example: the surface antigen of five indexes of hepatitis b), move the liquid process and specifically can comprise: distribute serum sample, enzyme marking reagent, developer A and developer B, stop buffer; Wherein, developer A and developer B are the developer that is adopted in the ELISA method.Therefore in the ELISA checkout procedure; Need the operation of a plurality of micropipettes; And in moving the liquid process; The liquid condition of serum sample or reagent influences the accuracy of application of sample amount, if there are situation such as grumeleuse, bubble or amount of liquid deficiency in serum sample or reagent, then can influence the precision of application of sample amount; In addition, the application of sample rifle leakage may occur or hang liquid moving the liquid process, causes the cross pollution of hyperchannel liquor-transferring system, thereby makes testing result erroneous judgement occur.
Summary of the invention
The object of the present invention is to provide a kind of micropipette detection system and method, the liquid process monitoring is surveyed and moved to the pressure of application of sample rifle, improve the precision of application of sample amount and avoid liquid to cause cross pollution through pressure transducer.
The embodiment of the invention provides a kind of micropipette detection system, comprising:
Application of sample rifle rifle body;
Be arranged on the pressure transducer in the said application of sample rifle rifle body; Be used for the gaseous tension situation in the said application of sample rifle rifle body body is monitored in real time, in the imbibition process of the hyperchannel liquor-transferring system that said application of sample rifle rifle body belongs to, obtain the real-time pressure values in the said application of sample rifle rifle body;
First acquisition module is used for the monitoring result in the real-time pressure values that said imbibition process gets access to according to said pressure transducer is obtained said application of sample rifle rifle body;
First determination module is used for confirming according to said monitoring result and preset a plurality of pressure curve the state of the hyperchannel liquor-transferring system at said application of sample rifle rifle body place.
The embodiment of the invention also provides a kind of micropipette detection method, comprising:
Pressure transducer through being arranged in the application of sample rifle rifle body is monitored the gaseous tension situation in the said application of sample rifle rifle body in real time, in the imbibition process of the hyperchannel liquor-transferring system that said application of sample rifle rifle body belongs to, obtains the real-time pressure values in the said application of sample rifle rifle body;
The real-time pressure values that in said imbibition process, gets access to according to said pressure transducer is obtained the monitoring result in the said application of sample rifle rifle body;
Confirm the state of the hyperchannel liquor-transferring system at said application of sample rifle rifle body place according to said monitoring result and preset a plurality of pressure curve.
Micropipette detection system provided by the invention and method; Through adopts pressure sensor the gaseous tension situation in the application of sample rifle rifle body is monitored in real time; Thereby realization is surveyed with the imbibition process of hyperchannel liquor-transferring system the pressure liquid level in the application of sample rifle rifle body and is monitored; Improve precision and the sensitivity of hyperchannel liquor-transferring system in the application of sample process, avoided the cross pollution of the liquid of hyperchannel liquor-transferring system.
Description of drawings
In order to be illustrated more clearly in the embodiment of the invention or technical scheme of the prior art; To do to introduce simply to the accompanying drawing of required use in embodiment or the description of the Prior Art below; Obviously, the accompanying drawing in describing below only is some embodiments of the present invention, for those of ordinary skills; Under the prerequisite of not paying creative work, can also obtain other accompanying drawing according to these accompanying drawings.
Fig. 1 is the structural representation of an embodiment of micropipette detection system of the present invention;
Fig. 2 is the structural representation of another embodiment of micropipette detection system of the present invention;
The synoptic diagram of the first preset pressure curve when Fig. 3 is an accurate application of sample embodiment illustrated in fig. 2;
The synoptic diagram of the second preset pressure curve when Fig. 4 is an empty cup stage embodiment illustrated in fig. 2;
The synoptic diagram of the 3rd preset pressure curve when Fig. 5 is a blood clotting state embodiment illustrated in fig. 2;
Fig. 6 is the synoptic diagram of preset pressure curve of the 4th when having the bubble state embodiment illustrated in fig. 2;
Fig. 7 is the schematic flow sheet of an embodiment of micropipette detection method of the present invention.
Embodiment
To combine the accompanying drawing in the embodiment of the invention below, the technical scheme in the embodiment of the invention is carried out clear, intactly description, obviously, described embodiment only is the present invention's part embodiment, rather than whole embodiment.Based on the embodiment among the present invention, those of ordinary skills are not making the every other embodiment that is obtained under the creative work prerequisite, all belong to the scope of the present invention's protection.
Application of sample rifle described in the embodiment of the invention is made up of rifle body, liquid-transfering gun signal plate, piston, the separatory motor that moves liquid point, control piston, the structures such as extruding motor of getting pin and abandoning pin; Because the application of sample rifle is that those of ordinary skills are known, so the embodiment of the invention repeats no more to the concrete structure and the function of application of sample rifle; In addition, one of ordinary skill in the art will appreciate that the hyperchannel liquor-transferring system described in the embodiment of the invention is specially moves the system that the liquid process is adopted in ELISA.
Fig. 1 is the structural representation of an embodiment of micropipette detection system of the present invention; As shown in Figure 1, the embodiment of the invention specifically comprises: application of sample rifle rifle body 11, be arranged on pressure transducer 12 in the application of sample rifle rifle body 11, first acquisition module 13 that is connected with pressure transducer 12, first determination module 14 that is connected with first acquisition module 13.In addition, 11 1 ends of application of sample rifle rifle body are provided with piston, and another end is connected with application of sample point 10, is equiped with liquid in the application of sample point 10, and the liquid in the embodiment of the invention specifically can be pure water, serum sample or reagent.
Wherein, the gaseous tension situation in 12 pairs of application of sample rifles of pressure transducer rifle body 11 is monitored in real time, in the imbibition process of the hyperchannel liquor-transferring system that application of sample rifle rifle body 11 belongs to, obtains the real-time pressure values of liquid level in the application of sample rifle 11 rifle bodies; The real-time pressure values that first acquisition module 13 gets access to according to pressure transducer 12 in said imbibition process is obtained the monitoring result in the application of sample rifle rifle body 11; First determination module 14 is confirmed the residing state of hyperchannel liquor-transferring system at application of sample rifle rifle body 11 places according to said monitoring result and preset a plurality of pressure curve.
The micropipette detection system that the embodiment of the invention provides; Gaseous tension situation through in 12 pairs of application of sample rifles of adopts pressure sensor rifle body 11 is monitored in real time; Thereby realization is surveyed with the imbibition process of hyperchannel liquor-transferring system the pressure liquid levels in the application of sample rifle rifle body 11 and is monitored; Improve precision and the sensitivity of hyperchannel liquor-transferring system in the application of sample process, avoided the cross pollution of the liquid of hyperchannel liquor-transferring system.
Fig. 2 is the structural representation of another embodiment of micropipette detection system of the present invention; As shown in Figure 2, the embodiment of the invention comprises: application of sample rifle rifle body 21, be arranged on pressure transducer 22 in the application of sample rifle rifle body 21, first acquisition module 23 that is connected with pressure transducer 22, first determination module 24 that is connected with first acquisition module 23, second determination module 25, instruction sending module 26, alarm module 27.In addition, 21 1 ends of application of sample rifle rifle body are provided with piston, and another end is connected with application of sample point 20, is equiped with liquid in the application of sample point 20.
Wherein, the gaseous tension situation in 22 pairs of application of sample rifles of pressure transducer rifle body 21 is monitored in real time, in the imbibition process of the hyperchannel liquor-transferring system that application of sample rifle rifle body 21 belongs to, obtains the real-time pressure values of liquid level in the application of sample rifle 21 rifle bodies; The real-time pressure values that first acquisition module 23 gets access to according to pressure transducer 22 in said imbibition process is obtained the monitoring result in the application of sample rifle rifle body 21; First determination module 24 is confirmed the residing state of hyperchannel liquor-transferring system at application of sample rifle rifle body 21 places according to said monitoring result and preset a plurality of pressure curve.After said imbibition process finished, second determination module 25 confirmed according to said real-time pressure values whether said application of sample rifle rifle body is in the leakage state; If said application of sample rifle rifle body is in the leakage state, then instruction sending unit 26 sends instruction to said hyperchannel liquor-transferring system, so that said hyperchannel liquor-transferring system quits work according to said instruction; If said real-time pressure values surpasses preset imbibition pressure curve error range band, then alarm module 27 sends failure alarm signal to said hyperchannel liquor-transferring system.
Further, the preset a plurality of pressure curve in the embodiment of the invention specifically comprise the first preset pressure curve, the second preset pressure curve, the 3rd preset pressure curve, the 4th preset pressure curve.The center line of imbibition pressure curve error band is the first preset pressure curve; What one of ordinary skill in the art will appreciate that is; Imbibition pressure curve error band can be the center for presetting pressure curve with first; Along the first preset pressure curve is the symmetrically arranged error range in center, so the embodiment of the invention is not done exemplary illustration to imbibition pressure curve error band.
Further, first acquisition module 23 can also comprise: AD conversion unit 231, first comparing unit 232; Wherein, AD conversion unit 231 converts said real-time pressure values to digital signal in said imbibition process; The variation tendency of first comparing unit 232 said digital signal of monitoring between first moment and second moment obtains monitoring result according to said variation tendency.
Further, first determination module 24 can also comprise: first confirms the 243, the 4th definite unit 244, the 242, the 3rd definite unit, 241, second definite unit, unit; Wherein, if the said monitoring result and the first preset pressure curve are consistent, then first confirms that unit 241 definite said hyperchannel liquor-transferring systems are in accurate application of sample state; If the said monitoring result and the second preset pressure curve are consistent, then second confirms that unit 242 definite said hyperchannel liquor-transferring systems are in empty cup stage; If said monitoring result and the 3rd preset pressure curve are consistent, then the 3rd confirms that unit 243 definite said hyperchannel liquor-transferring systems are in the blood clotting state; If said monitoring result and the 4th preset pressure curve are consistent, then the 4th confirms that there is bubble in unit 244 definite said hyperchannel liquor-transferring systems.
The micropipette detection system that the embodiment of the invention provides; Gaseous tension situation through in 22 pairs of application of sample rifles of adopts pressure sensor rifle body 21 is monitored in real time; Thereby realization is surveyed with the imbibition process of hyperchannel liquor-transferring system the pressure liquid level in the application of sample rifle 21 rifle bodies and is monitored; Improve precision and the sensitivity of hyperchannel liquor-transferring system in the application of sample process, avoided the cross pollution of the liquid of hyperchannel liquor-transferring system.
For clearer understanding technical scheme embodiment illustrated in fig. 2, specifically describe embodiment illustrated in fig. 2 through Fig. 3 and Fig. 4 below.
The synoptic diagram of the first preset pressure curve when Fig. 3 is an accurate application of sample embodiment illustrated in fig. 2; The synoptic diagram of the second preset pressure curve when Fig. 4 is an empty cup stage embodiment illustrated in fig. 2; The synoptic diagram of the 3rd preset pressure curve when Fig. 5 is a blood clotting state embodiment illustrated in fig. 2, Fig. 6 is the synoptic diagram of the 4th preset pressure curve when having the bubble state embodiment illustrated in fig. 2.In Fig. 2～Fig. 6, horizontal ordinate express time t, unit is a millisecond (ms), the corresponding digital signal conversion value of real-time pressure values that ordinate p (t) expression pressure transducer 22 monitors.
In the embodiment of the invention, application of sample point 20 is specially the standard application of sample point of 300 microlitres of not being with screen pack, and indoor temperature remains on 25 ℃.When first in the embodiment of the invention constantly is 120ms; Second is 700ms constantly; What one of ordinary skill in the art will appreciate that is; First moment and second constantly can be carried out accommodation according to the volume of liquid in the application of sample point, and 120ms and 700ms cited in the embodiment of the invention can not form the restriction to the embodiment of the invention.
If the monitoring result and the first preset pressure curve are consistent; Represent that promptly the monitoring result that first comparison module 23 monitors is as shown in Figure 3: when normal imbibition; Before 240ms, application of sample point 20 does not contact liquid level, the value (promptly near atmospheric pressure) about 760 that digital signal is corresponding; Between the 240ms～700ms, the 10 beginning imbibitions of application of sample point; After imbibition was accomplished, the corresponding value of digital signal returned to about about 500; Therefore can confirm that through this monitoring result the hyperchannel liquor-transferring system is in accurate application of sample state.
If the monitoring result and the second preset pressure curve are consistent; Represent that promptly the monitoring result that first comparison module 23 monitors is as shown in Figure 4: the digital signal conversion value of monitoring result reduces rapidly after 240ms; To monitor the atmospheric pressure of air pressure and external environment in the application of sample point 20 equal basically for pressure transducer 22 after the 460ms; Be that the digital signal conversion value is about 720, the digital signal conversion value that the atmospheric pressure of external environment is corresponding is 750; Therefore can confirm that the hyperchannel liquor-transferring system is in empty cup stage through this monitoring result, this empty cup stage representes that the test tube or the reagent cup that are arranged in application of sample point 20 belows do not have enough liquid, so just can't be drawn onto liquid in the application of sample point 20.
If monitoring result and the 3rd preset pressure curve are consistent; Represent that promptly the monitoring result that first comparison module 23 monitors is as shown in Figure 5: after 240ms; Pressure in the application of sample rifle rifle body 21 is said decline rapidly; This kind situation representes that stifled pin takes place application of sample point 20, and application of sample point 20 can not in time be drawn the test tube of below or the liquid in the reagent cup; Therefore can confirm that the hyperchannel liquor-transferring system is in the blood clotting state through this monitoring result.
If monitoring result and the 4th preset pressure curve are consistent; Represent that promptly the monitoring result that first comparison module 23 monitors is as shown in Figure 6: between the 240ms～420ms; The internal gas pressure of application of sample rifle rifle body 21 increases and occurs shaking; The corresponding digital signal conversion value of monitoring result shows as of short duration fluctuation, and the digital signal conversion value tends to balance after 420ms, and this kind situation representes that there is bubble in the liquid in the application of sample rifle rifle body 21; Therefore can confirm that there is bubble in the hyperchannel liquor-transferring system through this monitoring result.
The embodiment of the invention; Utilize the imbibition process of pressure monitor sensor hyperchannel liquor-transferring system; In the imbibition process, the pressure of application of sample rifle rifle body 21 can be compared through monitoring result and the preset a plurality of pressure curve that pressure transducer 22 is monitored by real-time monitoring; Can judge the hyperchannel liquor-transferring system and be in which kind of state, for example: accurately there is bubble etc. in the liquid in application of sample, empty cup, blood clotting, the application of sample rifle rifle body 21; In addition; Because pressure transducer 22 monitoring imbibition process reactions are sensitive; Therefore monitoring real-time pressure values above preset imbibition pressure curve error range band; Can send failure alarm signal to the hyperchannel liquor-transferring system through alarm module 27, therefore can find in time whether the hyperchannel liquor-transferring system exists fault.
In addition; What one of ordinary skill in the art will appreciate that is; Described in the embodiment of the invention first preset pressure curve, the second preset pressure curve, the 3rd preset pressure curve, the 4th preset pressure curve can be according to the model and the volume accommodation of concrete kind of liquid and application of sample point; Just those of ordinary skills are clearer to understand the described technical scheme of the embodiment of the invention to the preset pressure curve of above-mentioned Fig. 3-shown in Figure 6 in order to make, and can not form the restriction to the embodiment of the invention.
Fig. 7 is the schematic flow sheet of an embodiment of micropipette detection method of the present invention, and the micropipette detection system of embodiment illustrated in figures 1 and 2 can realize the method flow of the embodiment of the invention; As shown in Figure 7, the embodiment of the invention comprises the steps:
The micropipette detection method that the embodiment of the invention provides; Realize through adopts pressure sensor in the cavity of application of sample rifle the pressure detecting liquid level with move the liquid process monitoring; Improve the precision and the sensitivity of application of sample process, thereby avoided the cross pollution of the liquid of hyperchannel liquor-transferring system.
Further, above-mentioned embodiment illustrated in fig. 7 in, step 702 can also comprise:
In said imbibition process, convert said real-time pressure values to digital signal;
The variation tendency of the said digital signal of monitoring obtains monitoring result according to said variation tendency between first moment and second moment.
Further, above-mentioned embodiment illustrated in fig. 7 in, preset a plurality of pressure curve comprise the first preset pressure curve, the second preset pressure curve, the 3rd preset pressure curve, the 4th preset pressure curve, then the micropipette detection method can also comprise:
If the said monitoring result and the first preset pressure curve are consistent, confirm that then said hyperchannel liquor-transferring system is in accurate application of sample state;
If the said monitoring result and the second preset pressure curve are consistent, confirm that then said hyperchannel liquor-transferring system is in empty cup stage;
If said monitoring result and the 3rd preset pressure curve are consistent, confirm that then said hyperchannel liquor-transferring system is in the blood clotting state;
If said monitoring result and the 4th preset pressure curve are consistent, confirm that then there is bubble in said hyperchannel liquor-transferring system.
Further, above-mentioned embodiment illustrated in fig. 7 in, the micropipette detection method can also comprise:
After said imbibition process finishes, confirm according to said real-time pressure values and preset imbibition pressure curve error range band whether said application of sample rifle rifle body is in the leakage state;
If said application of sample rifle rifle body is in the leakage state, then send instruction, so that said hyperchannel liquor-transferring system quits work according to said instruction to said hyperchannel liquor-transferring system.
Further, above-mentioned embodiment illustrated in fig. 7 in, the micropipette detection method can also comprise:
If said real-time pressure values surpasses said imbibition pressure curve error range band, then send failure alarm signal to said hyperchannel liquor-transferring system.
One of ordinary skill in the art will appreciate that: all or part of step that realizes the foregoing description can be accomplished through the relevant hardware of programmed instruction; Aforesaid program can be stored in the computer read/write memory medium; This program the step that comprises said method embodiment when carrying out; And aforesaid storage medium comprises: various media that can be program code stored such as ROM, RAM, magnetic disc or CD.
What should explain at last is: above embodiment is only in order to explaining technical scheme of the present invention, but not to its restriction; Although with reference to previous embodiment the present invention has been carried out detailed explanation, those of ordinary skill in the art is to be understood that: it still can be made amendment to the technical scheme that aforementioned each embodiment put down in writing, and perhaps part technical characterictic wherein is equal to replacement; And these are revised or replacement, do not make the spirit and the scope of the essence disengaging various embodiments of the present invention technical scheme of relevant art scheme.
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| CN102880194A (en) * | 2012-09-17 | 2013-01-16 | 北京信息科技大学 | Motion controlling system and method for multiple channel pipetting plates |
| CN104237549A (en) * | 2014-09-30 | 2014-12-24 | 博奥赛斯（天津）生物科技有限公司 | Sample injection needle for chemiluminescence immunoassay analyzer |
| JP2020016449A (en) * | 2018-07-23 | 2020-01-30 | 株式会社日立ハイテクノロジーズ | Automatic analyzer and water leakage detection method of automatic analyzer |
| CN113624984A (en) * | 2021-08-11 | 2021-11-09 | 江苏拜明生物技术有限公司 | Application of sample arm with liquid level pressure detection function |
| CN113717852A (en) * | 2021-09-03 | 2021-11-30 | 重庆市盛佰昱科技有限公司 | Liquid suction method and liquid feeding method for biological tissue culture solution |
| CN114160224A (en) * | 2021-10-22 | 2022-03-11 | 成都开图医疗系统科技有限公司 | Micro sample injector and sample injection method |
| CN114441791A (en) * | 2021-12-23 | 2022-05-06 | 重庆异符科学仪器有限责任公司 | A pressure control-based micro sample adding device and sample adding method |
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| CN113624984A (en) * | 2021-08-11 | 2021-11-09 | 江苏拜明生物技术有限公司 | Application of sample arm with liquid level pressure detection function |
| CN113717852A (en) * | 2021-09-03 | 2021-11-30 | 重庆市盛佰昱科技有限公司 | Liquid suction method and liquid feeding method for biological tissue culture solution |
| CN114160224A (en) * | 2021-10-22 | 2022-03-11 | 成都开图医疗系统科技有限公司 | Micro sample injector and sample injection method |
| CN114441791A (en) * | 2021-12-23 | 2022-05-06 | 重庆异符科学仪器有限责任公司 | A pressure control-based micro sample adding device and sample adding method |
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