CN1080528A - The compound method of rifampin paste - Google Patents
The compound method of rifampin paste Download PDFInfo
- Publication number
- CN1080528A CN1080528A CN 92105210 CN92105210A CN1080528A CN 1080528 A CN1080528 A CN 1080528A CN 92105210 CN92105210 CN 92105210 CN 92105210 A CN92105210 A CN 92105210A CN 1080528 A CN1080528 A CN 1080528A
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- Prior art keywords
- paste
- rifampin
- compound method
- rifampicin
- dimethyl sulfoxide
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention is the compound method of a kind of rifampin paste (furuncle spirit ointment), it is characterized in that coating rifampicin with cyclodextrin, prevent its oxidation Decomposition, and add sulfur urine and in oil phase, add 2 at aqueous phase, the 6-ditertbutylparacresol is made antioxidant, further improve the oxidation resistance of rifampin paste, storage life was reached more than a year and a half, satisfied instructions for use.
Description
The present invention relates to the manufacturing technology of ointment, particularly a kind of rifampin paste manufacture method that prolongs storage life.
In the prior art, medicinal external application ointment such as fluocinonide ointment, Ascorbyl B6 paste and clobetasol propionate unguent, the following production technology of normal employing: principal agent is added to oil phase or aqueous phase mixing, allow water or oil phase under 70～80 ℃ isothermy, mix stirring then, until till the paste of formation below 45 ℃, promptly can be made into finished product.Rifampicin (RiFapicini) is a kind of broad ectrum antibiotic, is treatment active drug lungy, begins the eighties also to obtain good effect in order to the treatment bacterial infection.Yet, utilize rifampicin to make ointment in order to dermatosis such as treatment furuncle, but because rifampicin stability in aqueous solution is very poor, very easily oxidized decomposition and lose drug effect, in the oil-in-water type emulsifiable paste, if do not take special process, its storage life less than three months, the reason that this present just rifampin paste is difficult to carry out.
The objective of the invention is to overcome the problems referred to above of rifampicin, a kind of rifampin paste compound method that prolongs storage life is provided.
Compound method of the present invention following (material is all with listed as parts by weight): the cyclodextrin with 1.5～8% is added in 1% the rifampicin, and add a small amount of dimethyl sulfoxide and made it mixed grinding 2～5 hours, and then add an amount of dimethyl sulfoxide with paste mixture dilution (addition of dimethyl sulfoxide should be not more than 10%), method routinely subsequently, the aqueous phase that the rifampicin mixture slowly is added to 70～80 ℃ mixes, under situation about adding while stirring, mix stirring with isothermal oil phase more at last, drop to until temperature and promptly can be made into rifampin paste below 45 ℃.
The present invention mainly utilizes cyclodextrin that rifampicin is coated, to prevent its oxidation Decomposition.In order to make cyclodextrin can fully coat rifampicin, to calculate with its gram-molecular weight, the addition of cyclodextrin should be no less than 1.5%, but also unsuitable too high, otherwise can make mastic hardening and thickness too, is not easy to make and use.Water insoluble in view of rifampicin, therefore add dimethyl sulfoxide and make it to be convenient to dissolving.Requirement routinely, the addition of dimethyl sulfoxide should be not more than 10%, otherwise the mastic of making can produce stimulation to skin.In order further to improve the oxidation resistance of rifampin paste, the sulfur urine that is preferably in aqueous phase adding 0.2～0.5% is made water antioxidant, adds 0.01～0.02%2.6-ditertbutylparacresol and make oil phase antioxidant in oil phase.
By above-mentioned compound method, the rifampin paste of making can be preserved more than a year and a half, had satisfied instructions for use fully.
The present invention has following embodiment: (material is all in weight portion)
1. 5% cyclodextrin is added in 1% the rifampicin, takes by weighing 5% dimethyl sulfoxide, added a little and cyclodextrin and rifampicin mixed grinding earlier 3.5 hours, the dimethyl sulfoxide of remainder is added to makes it to be diluted to pasty state in the paste mixture subsequently.
2. urinate toward the sulfur of aqueous phase adding 0.5%.
3. add 0.02% 2.6-ditertbutylparacresol in the oil phase.
4. the aqueous phase that the pasty mixture in 1 slowly is added to 75 ℃ mixes.
5. the mixture in 4 is added in the mode that adds while stirring in 75 ℃ the oil phase, and continues to stir and drop to below 45 ℃, allow its natural cooling get final product until temperature.
Claims (3)
1, a kind of compound method of rifampin paste, it is characterized in that 1.5～8% cyclodextrin is added in 1% the rifampicin, and add a small amount of dimethyl sulfoxide and made it mixed grinding 2～5 hours, and then add an amount of dimethyl sulfoxide with paste mixture dilution (addition of dimethyl sulfoxide should be not more than 10%), method routinely subsequently, the aqueous phase that the rifampicin mixture slowly is added to 70～80 ℃ mixes, mix stirring with oil phase with the form that adds while stirring again, drop to below 45 ℃ until temperature and get final product (material is all with listed as parts by weight).
2, compound method according to claim 1 is characterized in that the sulfur urine in aqueous phase adding 0.2～0.5%.
3, compound method according to claim 1 is characterized in that adding 0.01～0.02% 2.6-ditertbutylparacresol in oil phase.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92105210 CN1029080C (en) | 1992-06-26 | 1992-06-26 | Preparation method of rifampicin ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92105210 CN1029080C (en) | 1992-06-26 | 1992-06-26 | Preparation method of rifampicin ointment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1080528A true CN1080528A (en) | 1994-01-12 |
| CN1029080C CN1029080C (en) | 1995-06-28 |
Family
ID=4941229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92105210 Expired - Fee Related CN1029080C (en) | 1992-06-26 | 1992-06-26 | Preparation method of rifampicin ointment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1029080C (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005074937A1 (en) * | 2004-02-04 | 2005-08-18 | Vinay Ramakant Sapte | Oral cyclodextrin complexes of anti-tuberculosis drug |
| US7001893B2 (en) * | 2002-10-28 | 2006-02-21 | Council Of Scientific And Industrial Research | Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof |
-
1992
- 1992-06-26 CN CN 92105210 patent/CN1029080C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7001893B2 (en) * | 2002-10-28 | 2006-02-21 | Council Of Scientific And Industrial Research | Inclusion complex of Rifampicin, an anti-tubercular drug, with β-cyclodextrin or 2-hydroxypropyl β-cyclodextrin and a process thereof |
| WO2005074937A1 (en) * | 2004-02-04 | 2005-08-18 | Vinay Ramakant Sapte | Oral cyclodextrin complexes of anti-tuberculosis drug |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1029080C (en) | 1995-06-28 |
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| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |