CN108031008A - A hysteresis heating device with precise temperature control for local treatment of diseased tissue - Google Patents
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Abstract
本发明公开了一种用于局部治疗病变组织的精确控温磁滞加热装置，属于医疗器械技术领域。本装置包括磁性纳米材料、磁场发生器、位移机构、温度探针、主控制器和变频电源；所述磁性纳米材料用于置入到病变组织处；所述磁场发生器用于产生交变磁场，使位于该交变磁场内的纳米材料运动磁滞生热；所述位移机构用于调节磁场发生器的作用位置；所述温度探针用于探测病变组织处的温度；所述主控制器用于控制位移机构的运动，预设温度及时间；所述变频电源的输入端外接工频电源，输出端连接磁场发生器，为磁场发生器提供合适的交变电能。本发明具有精确控制加热温度，降低正常组织的损伤，高效去除病变组织等优点。
The invention discloses a precisely temperature-controlled hysteresis heating device for local treatment of pathological tissues, belonging to the technical field of medical instruments. The device includes a magnetic nanomaterial, a magnetic field generator, a displacement mechanism, a temperature probe, a main controller and a variable frequency power supply; the magnetic nanomaterial is used to be placed in a diseased tissue; the magnetic field generator is used to generate an alternating magnetic field, The hysteresis of the nanomaterials in the alternating magnetic field generates heat; the displacement mechanism is used to adjust the action position of the magnetic field generator; the temperature probe is used to detect the temperature at the diseased tissue; the main controller is used to The movement of the displacement mechanism is controlled, and the temperature and time are preset; the input end of the variable frequency power supply is externally connected to a commercial frequency power supply, and the output end is connected to a magnetic field generator to provide suitable alternating electric energy for the magnetic field generator. The invention has the advantages of precisely controlling the heating temperature, reducing damage to normal tissues, and efficiently removing pathological tissues.
Description
技术领域technical field
本发明属于医疗器械技术领域，涉及一种用于局部治疗病变组织的精确控温磁滞加热装置。The invention belongs to the technical field of medical devices, and relates to a hysteresis heating device with precise temperature control for local treatment of diseased tissues.
背景技术Background technique
热疗是一种常见的物理治疗方式,主要是将生物体内病变机体组织加热以致其死亡的治疗方式。在热疗的过程中，当生物体全身或某一局部区域被加热其温度上升时，会导致血管扩张，增加治疗部位的血流量。在增加治疗部位血流量的同时，热疗可以加速身体的新陈代谢，让营养物质快速到达受伤的部位，促使组织的愈合。另外，热疗还可以激发生物体的免疫系统消灭病毒、病菌以及寄生虫。而肿瘤热疗则利用癌细胞较正常细胞不耐热的生理现象，将肿瘤组织加热后杀死肿瘤细胞，是一种称为高温热疗的热疗方法之一，是继手术、放疗和化疗之后的“绿色疗法”。肿瘤热疗一般分为全身热疗、局域热疗两种。局域热疗使肿瘤组织局部温度达到42.5℃以上，能在相对较短的时间内杀灭癌细胞，而对周围的正常细胞和组织有较少的损伤。目前，局域热疗按照加热方式可以分为微波辐射、射频辐射、超声波聚焦、电阻加热、交变磁场加热磁粒子等方法。微波辐射、射频辐射、超声波聚焦、电阻加热等传统热疗方式由于各种缺点正逐步被交变磁场加热磁粒子的方式所取代。Hyperthermia is a common physical therapy method, which is mainly to heat the diseased body tissues in the living body so as to cause its death. In the process of hyperthermia, when the whole body of the organism or a certain local area is heated and its temperature rises, it will cause the blood vessels to dilate and increase the blood flow at the treatment site. While increasing the blood flow in the treatment area, hyperthermia can accelerate the body's metabolism, allowing nutrients to quickly reach the injured area and promote tissue healing. In addition, hyperthermia can also stimulate the immune system of the organism to eliminate viruses, germs and parasites. Tumor hyperthermia uses the physiological phenomenon that cancer cells are less resistant to heat than normal cells, and kills tumor cells after heating the tumor tissue. It is one of the hyperthermia methods called high-temperature hyperthermia. After the "green therapy". Tumor hyperthermia is generally divided into whole body hyperthermia and local hyperthermia. Local hyperthermia makes the local temperature of tumor tissue reach above 42.5°C, which can kill cancer cells in a relatively short period of time, while causing less damage to surrounding normal cells and tissues. At present, local hyperthermia can be divided into microwave radiation, radio frequency radiation, ultrasonic focusing, resistance heating, alternating magnetic field heating of magnetic particles and other methods according to the heating method. Due to various shortcomings, traditional hyperthermia methods such as microwave radiation, radio frequency radiation, ultrasonic focusing, and resistance heating are gradually being replaced by the method of heating magnetic particles with an alternating magnetic field.
交变磁场加热磁粒子的方式是较为新颖高效的热疗方式。主要的原理是将磁性粒子材料注入或者靶向植入病变组织，在外部施加交变磁场，由于涡流损耗、磁滞损耗的存在致使磁性材料产生热量，以消融局部的坏死组织或癌变组织。名称为“将磁场作用于磁性颗粒的应用方法”(申请号为200610027027.5)的专利中介绍了将磁性颗粒与治疗用品混合后置入到生物组织和细胞中，之后再对置入处施加交变磁场，使磁性颗粒运动生热，从而达到治疗的目的。该种方法虽然从理论上来说可行，但是如何具体的利用仪器以实现该热疗的目的却并没有提及。The way of heating magnetic particles by alternating magnetic field is a relatively new and efficient way of hyperthermia. The main principle is to inject or implant magnetic particle materials into diseased tissues, apply an alternating magnetic field externally, and generate heat due to the existence of eddy current loss and hysteresis loss, so as to ablate local necrotic or cancerous tissues. The patent titled "Application Method of Applying Magnetic Field to Magnetic Particles" (Application No. 200610027027.5) introduces that magnetic particles are mixed with therapeutic products and placed into biological tissues and cells, and then alternating The magnetic field makes the magnetic particles move to generate heat, so as to achieve the purpose of treatment. Although this method is theoretically feasible, how to specifically utilize the instrument to realize the purpose of the hyperthermia has not been mentioned.
磁滞加热治疗仪的设计要考虑多方面的因素。要有效的实现热疗目的不仅要看考虑病变组织还要考虑正常组织。因为在热疗过程中，加热的区域会受到磁性粒子运动分布的影响，所以不可避免的会扩散到正常的组织中去，如此正常组织也会受到损伤。不同组织的病理特征对应不同的最适宜加热温度，而磁性颗粒运动产生的温度是受多中因素影响决定的，在治疗过程中要使温度稳定的维持在该病变组织最适宜加热温度附近，如此才能实现最佳的治疗效果同时又减少对正常组织的损伤。The design of the hysteresis heating therapeutic apparatus should consider various factors. In order to effectively realize the purpose of hyperthermia, it is necessary to consider not only the diseased tissue but also the normal tissue. Because during the hyperthermia process, the heated area will be affected by the movement and distribution of magnetic particles, so it will inevitably spread to normal tissues, so normal tissues will also be damaged. The pathological characteristics of different tissues correspond to different optimum heating temperatures, and the temperature generated by the movement of magnetic particles is determined by many factors. In order to achieve the best therapeutic effect while reducing damage to normal tissues.
发明内容Contents of the invention
有鉴于此，本发明的目的在于提供一种用于局部治疗病变组织的精确控温磁滞加热装置。In view of this, the object of the present invention is to provide a hysteresis heating device with precise temperature control for locally treating diseased tissue.
为达到上述目的，本发明提供如下技术方案：To achieve the above object, the present invention provides the following technical solutions:
一种用于局部治疗病变组织的精确控温磁滞加热装置，包括磁性纳米材料、磁场发生器、位移机构、温度探针、主控制器和变频电源；A hysteresis heating device with precise temperature control for local treatment of diseased tissue, including magnetic nanomaterials, a magnetic field generator, a displacement mechanism, a temperature probe, a main controller and a variable frequency power supply;
所述磁性纳米材料用于置入到病变组织处，并且使其处于一个交变的磁场中；The magnetic nanomaterial is used to be placed in the diseased tissue and placed in an alternating magnetic field;
所述磁场发生器用于产生交变磁场，使位于该交变磁场内的纳米材料运动磁滞生热；The magnetic field generator is used to generate an alternating magnetic field, so that the hysteresis of the nanomaterials located in the alternating magnetic field generates heat;
所述位移机构与磁场发生器连接，用于调节磁场发生器的作用位置；The displacement mechanism is connected with the magnetic field generator for adjusting the action position of the magnetic field generator;
所述温度探针用于探测病变组织处的温度；The temperature probe is used to detect the temperature at the diseased tissue;
所述主控制器用于控制位移机构的运动，预设温度及时间，接收温度探针的信号并通过调节变频电源的输出频率、磁场发生器的磁场频率和强度来控制温度；The main controller is used to control the movement of the displacement mechanism, preset the temperature and time, receive the signal of the temperature probe and control the temperature by adjusting the output frequency of the variable frequency power supply and the magnetic field frequency and strength of the magnetic field generator;
所述变频电源的输入端外接工频电源，输出端连接磁场发生器，为磁场发生器提供合适的交变电能。The input end of the variable frequency power supply is externally connected to a commercial frequency power supply, and the output end is connected to a magnetic field generator to provide suitable alternating electric energy for the magnetic field generator.
进一步的，所述磁性材料在磁场强度小于或等于7.5×107A/m.s时，磁加热效率至少为8×10-8J.m/A.g。Further, the magnetic heating efficiency of the magnetic material is at least 8×10 -8 Jm/Ag when the magnetic field strength is less than or equal to 7.5×10 7 A/ms.
进一步的，所述磁性纳米材料采用四氧化三铁、三氧化二铁、钕铁硼和铁钴合金中的一种或者多种以上的合金、化合物或混合物。Further, the magnetic nanomaterial adopts one or more alloys, compounds or mixtures of ferric oxide, ferric oxide, neodymium-iron-boron and iron-cobalt alloy.
进一步的，所述磁纳米材料的结构为纳米颗粒、纳米棒、纳米线和纳米壳、多层壳层结构或笼型结构中的一种。Further, the structure of the magnetic nanomaterial is one of nanoparticle, nanorod, nanowire and nanoshell, multilayer shell structure or cage structure.
进一步的，所述磁性纳米材料的表面修饰采用无修饰、PEG包裹、静电吸附包裹、二氧化硅包裹、树枝状分子包裹、抗体修饰、生物蛋白修饰、生物多糖或糖蛋白修饰及药物大分子修饰中的一种。Further, the surface modification of the magnetic nanomaterials adopts non-modification, PEG encapsulation, electrostatic adsorption encapsulation, silica encapsulation, dendrimer encapsulation, antibody modification, biological protein modification, biological polysaccharide or glycoprotein modification and drug macromolecule modification One of.
进一步的，所述变频电源外接的工频电源为50Hz，输出的交变电源为20KHz～200KHz。Further, the commercial frequency power externally connected to the variable frequency power supply is 50 Hz, and the output alternating power is 20KHz-200KHz.
进一步的，所述变频电源包括整流器和桥式逆变频发生器，所述整流器用于将外接的交流电转换为直流电，所述桥式逆变频发生器用于改变直流电的频率并且将直流电再次转换为交流电。Further, the variable frequency power supply includes a rectifier and a bridge-type inverter generator, the rectifier is used to convert the external AC power into DC power, and the bridge-type inverter generator is used to change the frequency of the DC power and convert the DC power into AC power again .
进一步的，所述磁场发生器由一个或多个电感线圈构成，且所述电磁感线圈采用高温高压电线缠绕螺旋状。Further, the magnetic field generator is composed of one or more inductance coils, and the electromagnetic induction coils are wound with high-temperature and high-voltage wires in a helical shape.
进一步的，所述位移机构由外壳、步进伺服电机、减速机、滑动导轨和滑轮组成，所述外壳通过滑轮放置在滑动导轨上，所述磁场发生器放置在外壳内部，外壳连接步进伺服电机和减速机。Further, the displacement mechanism is composed of a housing, a stepping servo motor, a reducer, a sliding guide rail and a pulley, the housing is placed on the sliding guide rail through the pulley, the magnetic field generator is placed inside the housing, and the housing is connected to the stepping servo motor and reducer.
本发明的有益效果在于：本发明将磁性纳米材料置入到病变组织，同时将磁性纳米材料置于交变磁场中，由于磁滞现象产生热量用于消除病变组织；温度探针用于探测病变组织处的温度，同时利用主控制器进行温度的控制，所以本发明能够在有效除去病灶的同时减小对正常组织的伤害。The beneficial effects of the present invention are: the present invention inserts magnetic nanomaterials into diseased tissues, and at the same time places the magnetic nanomaterials in an alternating magnetic field to generate heat due to hysteresis to eliminate diseased tissues; temperature probes are used to detect pathological changes The temperature at the tissue is controlled by the main controller at the same time, so the present invention can effectively remove the lesion while reducing damage to normal tissue.
附图说明Description of drawings
为了使本发明的目的、技术方案和有益效果更加清楚，本发明提供如下附图进行说明：In order to make the purpose, technical scheme and beneficial effect of the present invention clearer, the present invention provides the following drawings for illustration:
图1为本发明的装置的连接及作用关系示意图；Fig. 1 is the connection of device of the present invention and action relation schematic diagram;
图2为本发明的位移机构结构示意图；Fig. 2 is the structural representation of displacement mechanism of the present invention;
其中：1-外壳；2-步进伺服电机；3-减速机；4-滑动导轨；5-滑轮；6-磁场发生器。Among them: 1-shell; 2-stepping servo motor; 3-reducer; 4-sliding guide rail; 5-pulley; 6-magnetic field generator.
具体实施方式Detailed ways
以下将结合附图，对本发明的优选实施例进行详细的描述；应当理解，优选实施例仅为了说明本发明，而不是为了限制本发明的保护范围。The preferred embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings; it should be understood that the preferred embodiments are only for illustrating the present invention, rather than limiting the protection scope of the present invention.
附图1是本发明的整体结构示意图，如图1所示，一种用于局部治疗病变组织的精确控温磁滞加热装置，包括磁性纳米材料、磁场发生器、位移机构、温度探针、主控制器和变频电源；Accompanying drawing 1 is the overall structure schematic diagram of the present invention, as shown in Figure 1, a kind of precise temperature control hysteresis heating device for local treatment of diseased tissue, including magnetic nanomaterials, magnetic field generator, displacement mechanism, temperature probe, Main controller and variable frequency power supply;
所述磁性纳米材料用于置入到病变组织处，并且使其处于一个交变的磁场中；The magnetic nanomaterial is used to be placed in the diseased tissue and placed in an alternating magnetic field;
所述磁场发生器用于产生交变磁场，使位于该交变磁场内的纳米材料运动磁滞生热；The magnetic field generator is used to generate an alternating magnetic field, so that the hysteresis of the nanomaterials located in the alternating magnetic field generates heat;
所述位移机构与磁场发生器连接，用于调节磁场发生器的作用位置；The displacement mechanism is connected with the magnetic field generator for adjusting the action position of the magnetic field generator;
所述温度探针用于探测病变组织处的温度；The temperature probe is used to detect the temperature at the diseased tissue;
所述主控制器用于控制位移机构的运动，预设温度及时间，接收温度探针的信号并通过调节变频电源的输出频率、磁场发生器的磁场频率和强度来控制温度；The main controller is used to control the movement of the displacement mechanism, preset the temperature and time, receive the signal of the temperature probe and control the temperature by adjusting the output frequency of the variable frequency power supply and the magnetic field frequency and strength of the magnetic field generator;
所述变频电源的输入端外接工频电源，输出端连接磁场发生器，为磁场发生器提供合适的交变电能。The input end of the variable frequency power supply is externally connected to a commercial frequency power supply, and the output end is connected to a magnetic field generator to provide suitable alternating electric energy for the magnetic field generator.
所述磁性材料在磁场强度小于或等于7.5×107A/m.s时，磁加热效率至少为8×10-8J.m/A.g。The magnetic heating efficiency of the magnetic material is at least 8×10 -8 Jm/Ag when the magnetic field strength is less than or equal to 7.5×10 7 A/ms.
所述磁性纳米材料采用四氧化三铁、三氧化二铁、钕铁硼和铁钴合金中的一种或者多种以上的合金、化合物或混合物。The magnetic nano material adopts one or more alloys, compounds or mixtures of ferric oxide, ferric oxide, neodymium iron boron and iron cobalt alloy.
所述磁纳米材料的结构为纳米颗粒、纳米棒、纳米线和纳米壳、多层壳层结构或笼型结构中的一种。The structure of the magnetic nanomaterial is one of nanoparticle, nanorod, nanowire and nanoshell, multilayer shell structure or cage structure.
所述磁性纳米材料的表面修饰采用无修饰、PEG包裹、静电吸附包裹、二氧化硅包裹、树枝状分子包裹、抗体修饰、生物蛋白修饰、生物多糖或糖蛋白修饰及药物大分子修饰中的一种。The surface modification of the magnetic nanomaterial adopts one of non-modification, PEG encapsulation, electrostatic adsorption encapsulation, silica encapsulation, dendrimer encapsulation, antibody modification, bioprotein modification, biopolysaccharide or glycoprotein modification, and drug macromolecule modification. kind.
所述变频电源外接的工频电源为50Hz，输出的交变电源为20KHz～200KHz。The commercial frequency power externally connected to the variable frequency power supply is 50Hz, and the output alternating power supply is 20KHz-200KHz.
所述变频电源包括整流器和桥式逆变频发生器，所述整流器用于将外接的交流电转换为直流电，所述桥式逆变频发生器用于改变直流电的频率并且将直流电再次转换为交流电。The variable frequency power supply includes a rectifier and a bridge-type inverter generator, the rectifier is used to convert external AC power into DC power, and the bridge-type inverter generator is used to change the frequency of the DC power and convert the DC power into AC power again.
所述磁场发生器由一个或多个电感线圈构成，且所述电磁感线圈采用高温高压电线缠绕螺旋状。The magnetic field generator is composed of one or more inductance coils, and the electromagnetic induction coils are wound with high-temperature and high-voltage wires in a helical shape.
所述位移机构由外壳1、步进侍服电机2、减速机3、滑动导轨4和滑轮5组成，所述外壳1通过滑轮5放置在滑动导轨4上，所述磁场发生器6放置在外壳1内部，外壳1连接步进伺服电机2和减速机3。The displacement mechanism is composed of a casing 1, a stepping servo motor 2, a reducer 3, a sliding guide rail 4 and a pulley 5, the casing 1 is placed on the sliding guide rail 4 through the pulley 5, and the magnetic field generator 6 is placed on the casing 1 Inside, the shell 1 connects the stepping servo motor 2 and the reducer 3.
在使用时先将磁性纳米材料置入到病变组织处，然后利用磁场发生器发出的交变磁场使磁性纳米材料产生磁滞现象发热，当温度升高到40～50摄氏度时，可以有效的消除病灶。同时在病变组织处置入温度探针，将采集到的温度信号反馈到主控制器，主控制器通过调节变频电源的输出频率、磁场发生器的磁场频率和强度来控制温度，避免温度太高对正常组织造成伤害。同时位移机构可以使磁场发生器根据实际情况来移动位置，准确的作用于病变组织处。When in use, the magnetic nanomaterials are placed into the diseased tissue first, and then the alternating magnetic field emitted by the magnetic field generator is used to cause the magnetic nanomaterials to generate hysteresis and generate heat. When the temperature rises to 40-50 degrees Celsius, it can be effectively eliminated. lesion. At the same time, a temperature probe is placed in the lesion tissue, and the collected temperature signal is fed back to the main controller. The main controller controls the temperature by adjusting the output frequency of the variable frequency power supply, the magnetic field frequency and strength of the magnetic field generator, and avoids excessive temperature damage. Damage to normal tissue. At the same time, the displacement mechanism can make the magnetic field generator move its position according to the actual situation, and accurately act on the diseased tissue.
以上所述仅为本发明的优选实施例，并不用于限制本发明，显然，本领域的技术人员可以对本发明进行各种改动和变型而不脱离本发明的精神和范围。这样，倘若本发明的这些修改和变型属于本发明权利要求及其等同技术的范围之内，则本发明也意图包含这些改动和变型在内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Obviously, those skilled in the art can make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalent technologies, the present invention also intends to include these modifications and variations.
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