CN204016940U - A kind of targeting drug-delivery system of antitumor magnetic nano-particle medicine - Google Patents
A kind of targeting drug-delivery system of antitumor magnetic nano-particle medicine Download PDFInfo
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- CN204016940U CN204016940U CN201420098512.1U CN201420098512U CN204016940U CN 204016940 U CN204016940 U CN 204016940U CN 201420098512 U CN201420098512 U CN 201420098512U CN 204016940 U CN204016940 U CN 204016940U
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Abstract
This utility model belongs to drug administration device product technical field.The concrete targeting drug-delivery system that discloses a kind of antitumor magnetic nano-particle medicine, comprise infusion vessel and with medicinal liquid conveyer device, at the body surface corresponding to tumor region, be provided with field generator for magnetic and bio electricity induction apparatus outward; Also comprise control device; On described field generator for magnetic, be connected with magnetic field control device; On described medicinal liquid conveyer device, be connected with flow speed controller, described control device is connected with bio electricity induction apparatus, magnetic field control device and flow speed controller are corresponding respectively.This targeting drug-delivery system flowing of nanoparticle antitumor drug that can deperm, can be preferably by medicine centralized Control in tumor region, make the drug level of tumor region higher, medicinal effects is good, while is according to bioelectrical signals feedback control magnetic field intensity and the medicinal liquid flow of tumor region tissue, improve the safety of property nanoparticle Drug therapy, be beneficial to the physical recovery of tumor sufferer, also reduced medicine to the unnecessary injury of other organs of human body.
Description
Technical field
This utility model belongs to drug administration device product technical field, particularly a kind of targeting drug-delivery system of antitumor magnetic nano-particle medicine.
Background technology
Nanoparticle refers to the particle (nanoparticle again claim ultrafine dust) of granularity between 1 to 100nm.The category that belongs to colloidal particle size.Their transition zone between cluster and macro object, between microsystem and meta system, are by the few atom of number or molecular group, so their both also atypical macroscopic systems of atypical microscopic system.Can predict, nanoparticle should have some strange physicochemical characteristicss.The feature that nanoparticle is different from macro object structure is, its surface area accounts for very large proportion, and both amorphous layer without short-range order without long-range order of surface atom.Can think that the state of nanoparticle surface atom more approaches gaseous state, and the atom of inside particles may be orderly arrangement, even so, because particle diameter is little, surface curvature is large, and the very high Gilibs pressure of inner generation, can cause certain distortion of internal structure.
Nano material also has many application in medical science and biological engineering, has successfully developed to take the targeted drug that nano magnetic material is pharmaceutical carrier, is called " biological missile ".At the coated protein surface of magnetic nano-particle, carry medicine, as shown in Figure 1, on the surface of magnetic nano-particle 10, carry antitumor drug 20, as Bleomycin A5, mode by physics or covalent bonds is combined into magnetic nano-particle antitumor drug 30, the mode of then this magnetic nano-particle antitumor drug 20 being injected by intravascular injection or tumor chamber enters human lesion and organizes, can reduce liver, spleen, the suffered side effect due to medicine generation such as kidney, but the injection of tumor chamber or vascular perfusion mode enter the medicine of focal zone, can absorb again and enter blood circulation, particularly blood is transported abundant focus, as angiosarcoma, malignant melanoma, deformation (hemangioma racemosum) and Venous malformations, focal zone blood flow rate is fast, it is of short duration in the time of staying of focal zone tissue after medicine enters, drug level is lower, medicinal effects is poor, affect the curative effect of tumor sufferer, in addition, entering sanguimotor medicine increases the damage of human tissue organ, therefore, research and develop a kind of targeting device that is controlled at tumor region that antitumor magnetic nano-particle medicine can be concentrated extremely urgent.
Utility model content
The purpose of this utility model is to overcome the deficiencies in the prior art, a kind of targeting drug-delivery system of antitumor magnetic nano-particle medicine is provided, this targeting drug-delivery system flowing of nanoparticle medicine that can deperm, can be preferably by medicine centralized Control in tumor region, make the drug level of tumor region higher, medicinal effects is good, is beneficial to the physical recovery of tumor sufferer, also reduces medicine to the unnecessary injury of human tissue organ.
In order to overcome above-mentioned technical purpose, this utility model is realized by following technical scheme:
The targeting drug-delivery system of a kind of antitumor magnetic nano-particle medicine described in the utility model, the medicinal liquid conveyer device that comprises the conveying antitumor magnetic nano-particle medicine for being loaded with the infusion vessel of antitumor magnetic nano-particle medicine and being connected with infusion vessel, is provided with outward and antitumor magnetic nano-particle medicine can be produced to the adsorbing field generator for magnetic of magnetic and the bio electricity induction apparatus of induction tumor region biological tissue to magnetic stimulation reaction at the body surface corresponding to tumor region; Also comprise being provided with and accept and analyze bio electricity induction apparatus signal and according to the control device of the required magnetic field intensity of bio electricity induction apparatus signal master control, transfusion speed and fluid flow; On described field generator for magnetic, be connected with the magnetic field control device of controlling magnetic field intensity; On described medicinal liquid conveyer device, be connected with the flow speed controller of controlling its flow velocity, described control device is connected with bio electricity induction apparatus, magnetic field control device and flow speed controller are corresponding respectively.
Further improvement as above-mentioned technology, described bio electricity induction apparatus comprises surface electrode or needle electrode, bioelectric amplifier and the signal processing system on the area for treatment surface that is positioned over corresponding tumor region, described surface electrode or needle electrode will detect the bio electricity reaction of area for treatment tissue to magnetic field force and the stimulation of magnetic Nano antitumor drug, through the bio electricity amplification of biological amplifier and the signal analysis and processing of signal processing system, send control device to.
In this utility model, described field generator for magnetic can have following two kinds of forms:
The first, described field generator for magnetic is the rotating excitation field that AC coil forms, it is fixed on outside the body surface corresponding to tumor region by fixture, and on described field generator for magnetic, be connected with the magnetic field control device of controlling magnetic field intensity and rotational speed of magnetic field, by magnetic field control device controlling magnetic field intensity and rotational speed of magnetic field effectively.
The second, described field generator for magnetic is some magnetic materials of arranging, described magnetic material by medical dressing or rubberized fabric adhere at the body surface external position corresponding to tumor region, described magnetic material is magnetite, is used for controlling the magnetic size of described magnetic devices by the quantity of regulating magnet stone; In addition,, in order to there is good air permeable effect, between described magnetic material and medical dressing or adhesive plaster, be filled with medical air-permeable material.
Compared with prior art, the beneficial effects of the utility model are:
(1) this utility model passes through corresponding to the field generator for magnetic described in tumor region body surface position, by magnetic Nano antitumor drug main concentrate on tumor region, strengthen the concentration of the antitumor drug of tumor region, minimizing tumour medicine absorbs and enters blood circulation, administration more targetedly, its medicinal effects is good, and can reduce the injury of medicine to other organs of human body;
(2) this utility model also can be provided with magnetic field control device, carrys out the intensity of controlling magnetic field, for tumor, is positioned at apart from the darker position of body surface, can improve magnetic field intensity, reduces on the contrary its intensity, and controllability is good, is easy to the health of human body.
(3) this utility model also can be provided with bio electricity induction apparatus, the bio electricity reaction that regional organization stimulates magnetic field force and magnetic Nano antitumor drug of receiving treatment, evaluate both to the coverage of tumor region tissue and intensity, feedback regulation magnetic field intensity and drug dose, be conducive to increase the accuracy for the treatment of, reduce complication and improve medical safety;
(4) this utility model is specially adapted to blood and transports abundant innocent and malignant tumour, by magnetic force, increase magnetic Nano antitumor drug in the time of staying in focus region, for the current low patients such as angiosarcoma, malignant melanoma, deformation (hemangioma racemosum) and Venous malformations of therapeutic effect bring new treatment to wish.
Accompanying drawing explanation
Below in conjunction with the drawings and specific embodiments, this utility model is described in detail:
Fig. 1 is magnetic nano-particle and antitumor drug cohesive process schematic diagram;
Fig. 2 is the targeting drug-delivery system structural representation of magnetic nano-particle antitumor drug described in the utility model;
Fig. 3 is bio electricity susceptor structures and the connection diagram thereof described in embodiment mono-;
Fig. 4 is the field generator for magnetic structural representation described in embodiment mono-;
Fig. 5 is magnetic Nano antitumor drug treatment schematic diagram;
Fig. 6 is the field generator for magnetic structural representation described in embodiment bis-.
The specific embodiment
Embodiment mono-:
As shown in Figure 2, the targeting drug-delivery system of a kind of antitumor magnetic nano-particle medicine described in the utility model, the medicinal liquid conveyer device 2 that comprises the conveying magnetic nano-particle antitumor drug for being loaded with the infusion vessel 1 of magnetic nano-particle antitumor drug and being connected with infusion vessel 1, produces the adsorbing field generator for magnetic 3 of magnetic and the bio electricity induction apparatus 4 of induction tumor region biological tissue to magnetic stimulation reaction in the body surface external enwergy corresponding to tumor region by antitumor magnetic nano-particle medicine; Also comprise being provided with and accept and analyze bio electricity induction apparatus 4 signals and according to the control device 5 of the required magnetic field intensity of bio electricity induction apparatus 4 signal master control, transfusion speed and fluid flow; On described field generator for magnetic 3, be connected with the magnetic field control device 6 of controlling magnetic field intensity; On described medicinal liquid conveyer device 3, be connected with the flow speed controller 7 of controlling its flow velocity, described control device 5 is respectively with bio electricity induction apparatus 4, magnetic field control device 6 with flow speed controller 7 is corresponding is connected.
As shown in Figure 3, described bio electricity induction apparatus 4 comprises surface electrode 41 or needle electrode 42, bioelectric amplifier and the signal processing system 43 on the area for treatment surface that is positioned over corresponding tumor region, and described bioelectric amplifier comprises interconnective preamplifier 44, high pass filter 45, isolated amplifier 46 and low pass filter 47.Described bio electricity sensor 4 reacts by skin surface electrodes 41 or needle electrode 42 bio electricity that regional organization stimulates magnetic field force and magnetic Nano antitumor drug of receiving treatment, bio electricity through biological amplifier amplifies and bioelectrical signals analyzing and processing, sends control device 5 to; Control device 5 is according to power and the scope of area for treatment bioelectrical signals, further regulate magnetic field intensity and medicinal liquid transporting velocity, this according to area for treatment tissue the bioelectrical signals to the reaction of magnetic force and medicine irritation, feed back in real time the control that regulates magnetic field control device 6 and flow speed controller 5, can effectively guarantee that accommodation accuracy is higher, use safer.
As shown in Figure 4, the rotating excitation field that described field generator for magnetic 3 forms for AC coil, it is fixed on outside the body surface corresponding to tumor region by fixture (not shown), and on described field generator for magnetic 3, be connected with the magnetic field control device 6 of controlling magnetic field intensity and rotational speed of magnetic field, by this magnetic field control device 6 controlling magnetic field intensity and rotational speed of magnetic field effectively, when the positional distance body surface of tumor is darker or more shallow, magnetic field control device 6 regulates the magnetic of field generator for magnetic 3 strong and weak in real time, easy to use, controllability is strong.Described field generator for magnetic 3 can be according to the configuration design of area for treatment corresponding shape, as above mandibular neoplasms is jawbone profile, brain tumor is cap shape, cervical region thyroid, extremity and thorax and abdomen malignant are tubular.
The operation principle of the present embodiment as shown in Figure 5, from blood vessel 40, flow into the magnetic nano-particle antitumor drug 30 of tumor region 50, under the absorption of field generator for magnetic 3, be controlled in tumor region 50, in tumor region 50, by the cell 60 of magnetic nano-particle labelling, can not continued to flow along blood vessel 40.
Embodiment bis-:
The present embodiment and embodiment mono-are basic identical, its difference is: as shown in Figure 6, described field generator for magnetic 3 is some magnetic materials of arranging, described magnetic material sticks on the body surface external position corresponding to tumor region by medical dressing or adhesive plaster 8, described magnetic material is magnetite, is used for controlling the magnetic size of described property device by the quantity of regulating magnet stone.Closely sealed for the profile of magnetic material and area for treatment, increase breathability and flexibility, can be between magnetic material, or filling medical air-permeable material between magnetic material and adhesive plaster.
This utility model is not limited to above-mentioned embodiment, every various changes of the present utility model or modification are not departed to spirit and scope of the present utility model, if these are changed and within modification belongs to claim of the present utility model and equivalent technologies scope, this utility model also means and comprises these changes and modification.
Claims (5)
1. the targeting drug-delivery system of an antitumor magnetic nano-particle medicine, the medicinal liquid conveyer device that comprises the conveying antitumor magnetic nano-particle medicine for being loaded with the infusion vessel of antitumor magnetic nano-particle medicine and being connected with infusion vessel, is characterized in that: at the body surface corresponding to tumor region, be provided with outward and antitumor magnetic nano-particle medicine can be produced to the adsorbing field generator for magnetic of magnetic and the bio electricity induction apparatus of induction tumor region biological tissue to magnetic stimulation reaction; Also comprise being provided with and accept and analyze bio electricity induction apparatus signal and according to the control device of the required magnetic field intensity of bio electricity induction apparatus signal master control, transfusion speed and fluid flow; On described field generator for magnetic, be connected with the magnetic field control device of controlling magnetic field intensity; On described medicinal liquid conveyer device, be connected with the flow speed controller of controlling its flow velocity, described control device is connected with bio electricity induction apparatus, magnetic field control device and flow speed controller are corresponding respectively;
Described bio electricity induction apparatus comprises surface electrode or needle electrode, bioelectric amplifier and the signal processing system on the area for treatment surface that is positioned over corresponding tumor region, described surface electrode or needle electrode will detect the bio electricity reaction of area for treatment tissue to magnetic field force and the stimulation of magnetic Nano antitumor drug, through the bio electricity amplification of biological amplifier and the signal analysis and processing of signal processing system, send control device to.
2. the targeting drug-delivery system of antitumor magnetic nano-particle medicine according to claim 1, is characterized in that: described field generator for magnetic is the rotating excitation field that AC coil forms, and it is fixed on outside the body surface corresponding to tumor region by fixture.
3. the targeting drug-delivery system of antitumor magnetic nano-particle medicine according to claim 1, it is characterized in that: described field generator for magnetic is some magnetic materials of arranging, described magnetic material by medical dressing or rubberized fabric adhere at the body surface external position corresponding to tumor region.
4. the targeting drug-delivery system of antitumor magnetic nano-particle medicine according to claim 3, is characterized in that: described magnetic material is magnetite.
5. the targeting drug-delivery system of antitumor magnetic nano-particle medicine according to claim 4, is characterized in that: between described magnetic material and medical dressing or adhesive plaster, be filled with medical air-permeable material.
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| CN201420098512.1U CN204016940U (en) | 2014-03-05 | 2014-03-05 | A kind of targeting drug-delivery system of antitumor magnetic nano-particle medicine |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103816578A (en) * | 2014-03-05 | 2014-05-28 | 广州一代医药科技有限公司 | Targeted drug delivery device for anti-tumor magnetic nanometer particle drug |
| CN106503423A (en) * | 2016-09-29 | 2017-03-15 | 东南大学 | Based on the microvascular implantation seed magnetic targeted experiment in vitro device and method of infiltration |
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2014
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103816578A (en) * | 2014-03-05 | 2014-05-28 | 广州一代医药科技有限公司 | Targeted drug delivery device for anti-tumor magnetic nanometer particle drug |
| WO2015131644A1 (en) * | 2014-03-05 | 2015-09-11 | 广州一代医药科技有限公司 | Targeted drug delivery device for anti-tumor magnetic nanoparticle drugs |
| CN103816578B (en) * | 2014-03-05 | 2016-04-27 | 广州一代医药科技有限公司 | A kind of targeting drug-delivery system of antitumor magnetic nano-particle medicine |
| CN106503423A (en) * | 2016-09-29 | 2017-03-15 | 东南大学 | Based on the microvascular implantation seed magnetic targeted experiment in vitro device and method of infiltration |
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| C14 | Grant of patent or utility model | ||
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| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141217 Termination date: 20160305 |