CN107898705A - It is a kind of can pre- anti-caries and canker sore mouthwash and preparation method thereof - Google Patents

Abstract

The invention belongs to the technical field of oral health care, and in particular relates to a mouthwash capable of preventing dental caries and oral ulcers, comprising the following raw materials in parts by weight: 5-10 parts of catechins, 5-10 parts of grape polyphenols, and 15-20 parts of gingerols 8-15 parts of chamomile hydrosol, 3-8 parts of vitamin C, 4-10 parts of folic acid, 1-3 parts of sweetener, 15-20 parts of Chinese medicine extract, and 10-20 parts of tea extract. The mouthwash of the present invention is made of pure natural raw materials, is safe, healthy, non-toxic and harmless, can be used as a daily care product for a long time, can effectively remove bacteria in the cavity, and better prevent dental caries and oral ulcers Effect, and long-term use has no side effects on the human body.

Description

Mouthwash capable of preventing dental caries and oral ulcers and preparation method thereof

technical field

The invention belongs to the technical field of oral health care, and in particular relates to a mouthwash capable of preventing dental caries and oral ulcers and a preparation method thereof.

Background technique

With the continuous improvement of people's living standards, more and more people begin to pay attention to oral health, among which dental caries and oral ulcers are the most common oral diseases. Dental caries is a bacterial disease, so it can cause secondary pulpitis and periapical periodontitis, and even cause alveolar bone and jaw inflammation. The secondary infection of dental caries can form lesions, causing or adding arthritis, pericardial Inflammation, chronic kidney disease and various eye diseases and other systemic diseases. Oral ulcer is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue abdomen, buccal mucosa, vestibular groove, soft palate and other parts. The cause of the disease is the result of a combination of various factors. Among them, bacteria such as Streptococcus sanguinis and Helicobacter pylori are closely related to the pathogenesis of oral ulcers.

Eliminating bacteria and maintaining oral hygiene are the most effective ways to prevent dental caries and oral ulcers. There are many mouthwashes with different ingredients on the market. Most of the mouthwashes in the prior art contain ingredients such as triclosan or metronidrone to enhance their oral health. Bactericidal and antibacterial effects, but long-term use of these ingredients will cause certain harm to the human body, so this type of mouthwash is not suitable for long-term use as daily oral care products.

Contents of the invention

The technical problem to be solved in the present invention is to develop a mouthwash that can prevent dental caries and oral ulcers, and the specific technical scheme is as follows:

A mouthwash capable of preventing dental caries and oral ulcers, comprising the following raw materials in parts by weight: 5-10 parts of catechin, 5-10 parts of grape polyphenols, 15-20 parts of gingerol, 8-15 parts of chamomile hydrosol, 3-8 parts of vitamin C, 4-10 parts of folic acid, 1-3 parts of sweetener, 15-20 parts of Chinese medicine extract, 10-20 parts of tea extract. 5-10 parts, 5-10 parts of honeysuckle, 1-5 parts of forsythia, 4-8 parts of Andrographis paniculata, 5-10 parts of licorice, 3-8 parts of Chinese gall, the tea extract includes the following raw materials in parts by weight: green tea 5 -10 parts, 5-10 parts of oolong tea, 5-10 parts of Kuding tea.

Preferably, the mouthwash that can prevent dental caries and oral ulcers includes the following raw materials in parts by weight: 9 parts of catechin, 6 parts of grape polyphenols, 15 parts of gingerol, 13 parts of chamomile hydrosol, 3 parts of vitamin C, 4 parts of folic acid 1 part of sweetener, 20 parts of traditional Chinese medicine extract, 20 parts of tea extract.

Preferably, the traditional Chinese medicine extract includes the following raw materials in parts by weight: 5 parts of Coptis chinensis, 8 parts of honeysuckle, 4 parts of forsythia, 6 parts of Andrographis paniculata, 8 parts of licorice, and 5 parts of gall.

Preferably, the tea extract includes the following raw materials in parts by weight: 10 parts of green tea, 5 parts of oolong tea, and 5 parts of Kuding tea.

As a preference, the Chinese medicine extract is prepared by the following method: mix the components and crush them to 50 mesh, add water and mix them evenly in a weight ratio of 1:2, then add yeast with a weight fraction of 0.5% and a weight fraction of 0.8 % cellulase mixed, fermented under the condition of 35 DEG C for 72 hours, added an equal weight mass fraction of 30% ethanol solution and stirred for 5 hours, then filtered and sterilized, and the filtrate was distilled under reduced pressure to remove ethanol to obtain the Chinese herbal extracts.

Preferably, the tea extract is prepared by the following method: add tea leaves to water, the weight ratio of tea leaves to water is 1:3, boil for 5 hours, and when cooled to 35-40°C, add yeast with a weight fraction of 0.2-0.5% Bacteria were mixed evenly, then stood at 35-40°C for 72 hours, added an equal weight of ethanol solution with a mass fraction of 30% and stirred for 4 hours, then filtered and sterilized, and the filtrate was distilled under reduced pressure to remove ethanol to obtain the Tea extract.

Preferably, the sweetener is aspartame or xylitol.

Preferably, it also includes 0.02 part of biological preservative and 0.1 part of biological antibacterial agent.

Preferably, the biological preservative consists of 50 wt% potassium sorbate and 50 wt% sodium sorbate.

Preferably, the biological antibacterial agent is chitosan.

The preparation method of the above-mentioned mouthwash that can prevent dental caries and oral ulcers includes: adding catechins, grape polyphenols, gingerol, vitamins, folic acid, sweeteners, biological preservatives and biological antibacterial agents into deionized water and stirring evenly , the weight ratio of raw materials to water is 1:3, heat up to 40-50°C, stir for 3 hours, then add chamomile hydrosol, traditional Chinese medicine extract, and tea extract in sequence, stir evenly, and cool down to room temperature to obtain the preventable Mouthwash for caries and mouth sores.

The method of using the mouthwash of the present invention: sooner or later or after three meals, 5-10ml for children, 10-20ml for adults, can be contained in the mouth for 30 seconds and then spit out. No need to rinse mouth with water after using this product. Do not eat within half an hour, so as not to reduce the effect.

Beneficial effects of the present invention

(1) The mouthwash of the present invention is made of pure natural raw materials, which is safe, healthy, non-toxic and harmless, can be used as a daily care product for a long time, can effectively remove bacteria in the oral cavity, and better prevent dental caries and oral cavity Ulcer effect, and long-term use without any side effects on the human body.

(2) in the mouthwash of the present invention, catechin can play better antibacterial, antibacterial and deodorizing functions; Grape polyphenols has stronger antioxidant effect; Gingerol is the main active ingredient in ginger , has antioxidant and antibacterial effects; chamomile hydrosol not only has the effect of reducing inflammation and inflammation, but also can freshen breath; vitamins and folic acid can effectively prevent oral ulcers; sweeteners can neutralize the bitterness of traditional Chinese medicine, making mouthwash The taste of the traditional Chinese medicine is better; the Chinese medicine extract is selected from traditional Chinese medicine with antibacterial and anti-inflammatory functions, which can effectively kill oral bacteria and prevent dental caries and oral ulcers, and the selected Chinese medicine ingredients can also play a role in antiseptic; tea extract The food is rich in catechins and polyphenols, which can have antioxidant and antibacterial effects, and can also neutralize the taste of mouthwash, making it have the fragrance of tea. The tea extracts are green tea, oolong tea, and Kudingcha. Raw materials, green tea is rich in catechins, oolong tea is rich in polyphenols after fermentation, and Kudingcha has good fire-reducing and anti-inflammatory effects.

Detailed ways

Example 1

A mouthwash capable of preventing dental caries and oral ulcers, comprising the following raw materials in parts by weight: 9 parts of catechin, 6 parts of grape polyphenols, 15 parts of gingerol, 13 parts of chamomile hydrosol, 3 parts of vitamin C, 4 parts of folic acid, 1 part of sweetener, 20 parts of Chinese medicine extract, 20 parts of tea extract. The traditional Chinese medicine extract comprises the following raw materials in parts by weight: 5 parts of Coptis chinensis, 8 parts of honeysuckle, 4 parts of forsythia, 6 parts of Andrographis paniculata, 8 parts of licorice, and 5 parts of Chinese gall. The tea extract comprises the following raw materials in parts by weight: 10 parts of green tea, 5 parts of oolong tea, and 5 parts of Kuding tea.

The preparation method of the above-mentioned mouthwash that can prevent dental caries and oral ulcers comprises: adding catechin, grape polyphenols, gingerol, vitamins, folic acid and sweeteners into deionized water and stirring evenly, and the weight ratio of raw materials to water is 1 : 3, heat up to 40-50°C, stir for 3 hours, then add chamomile hydrosol, traditional Chinese medicine extract, and tea extract in sequence, stir evenly, and cool down to room temperature to obtain the mouthwash that can prevent dental caries and oral ulcers.

Example 2

A mouthwash capable of preventing dental caries and oral ulcers, comprising the following raw materials in parts by weight: 5 parts of catechin, 5 parts of grape polyphenols, 15 parts of gingerol, 8 parts of chamomile hydrosol, 3 parts of vitamin C, 4 parts of folic acid, 1 part of sweetener, 15 parts of Chinese medicine extract, 10 parts of tea extract, said Chinese medicine extract includes the following raw materials in parts by weight: 5 parts of Huhuanglian, 5 parts of honeysuckle, 1 part of forsythia, 4 parts of Andrographis paniculata, 5 parts of licorice 3 parts, 3 parts of gallnut, the tea extract includes the following raw materials in parts by weight: 5 parts of green tea, 5 parts of oolong tea, 5 parts of Kuding tea.

The preparation method of the above-mentioned mouthwash that can prevent dental caries and oral ulcers comprises: adding catechin, grape polyphenols, gingerol, vitamins, folic acid and sweeteners into deionized water and stirring evenly, and the weight ratio of raw materials to water is 1 : 3, heat up to 40-50°C, stir for 3 hours, then add chamomile hydrosol, traditional Chinese medicine extract, and tea extract in sequence, stir evenly, and cool down to room temperature to obtain the mouthwash that can prevent dental caries and oral ulcers.

Example 3

A mouthwash capable of preventing dental caries and oral ulcers, comprising the following raw materials in parts by weight: 10 parts of catechin, 10 parts of grape polyphenols, 20 parts of gingerol, 15 parts of chamomile hydrosol, 8 parts of vitamin C, 10 parts of folic acid, 3 parts of sweetener, 20 parts of Chinese medicine extract, 20 parts of tea extract, the Chinese medicine extract includes the following raw materials in parts by weight: 10 parts of Coptis chinensis, 10 parts of honeysuckle, 5 parts of forsythia, 8 parts of Andrographis paniculata, 10 parts of licorice 8 parts, 8 parts of Galla chinensis, and described tea extract comprises the raw material of following weight part: 10 parts of green tea, 10 parts of oolong tea, 10 parts of Kuding tea.

The Chinese medicine extract is prepared by the following method: mix the components and pulverize them to 50 mesh, add water and mix them evenly at a weight ratio of 1:2, then add yeast with a weight fraction of 0.5% and fiber with a weight fraction of 0.8% After mixing the enzymes, fermenting at 35°C for 72 hours, adding an equal weight of 30% ethanol solution and stirring for 5 hours, then filtering and sterilizing, the filtrate was distilled under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extract things.

Example 4

A mouthwash capable of preventing dental caries and oral ulcers, comprising the following raw materials in parts by weight: 6 parts of catechin, 9 parts of grape polyphenols, 18 parts of gingerol, 10 parts of chamomile hydrosol, 5 parts of vitamin C, 5 parts of folic acid, 2 parts of sweetener, 19 parts of Chinese medicine extract, and 15 parts of tea extract. The Chinese medicine extract includes the following raw materials in parts by weight: 6 parts of Huhuanglian, 6 parts of honeysuckle, 3 parts of forsythia, 5 parts of Andrographis paniculata, 8 parts of licorice 7 parts, 7 parts of gallnut, the tea extract includes the following raw materials in parts by weight: 8 parts of green tea, 6 parts of oolong tea, 5 parts of Kuding tea.

The tea extract is prepared by the following method: add tea leaves to water, the weight ratio of tea leaves to water is 1:3, boil for 5 hours, and when cooled to 35-40°C, add yeast with a weight fraction of 0.2% and mix evenly, then Stand still at 35-40°C for 72 hours, add an equal weight of 30% ethanol solution and stir for 4 hours, then filter and sterilize, and distill the filtrate to remove ethanol under reduced pressure to obtain the tea extract.

Example 5

A mouthwash capable of preventing dental caries and oral ulcers, comprising the following raw materials in parts by weight: 8 parts of catechin, 7 parts of grape polyphenols, 17 parts of gingerol, 14 parts of chamomile hydrosol, 7 parts of vitamin C, 5 parts of folic acid, 1 part of aspartame, 16 parts of Chinese medicine extract, 10 parts of tea extract, 0.02 part of biological preservative and 0.1 part of biological antibacterial agent, the biological preservative is composed of 50 wt% potassium sorbate and 50 wt% sodium sorbate , the biological antibacterial agent is chitosan.

The Chinese medicine extract includes the following raw materials in parts by weight: 9 parts of Coptis chinensis, 8 parts of honeysuckle, 4 parts of Forsythia, 7 parts of Andrographis paniculata, 9 parts of licorice, and 7 parts of Galla gall. The tea extract includes the following raw materials in parts by weight: 9 parts of green tea, 9 parts of oolong tea, 6 parts of Kuding tea.

The Chinese medicine extract is prepared by the following method: mix the components and pulverize them to 50 mesh, add water and mix them evenly at a weight ratio of 1:2, then add yeast with a weight fraction of 0.5% and fiber with a weight fraction of 0.8% After mixing the enzymes, fermenting at 35°C for 72 hours, adding an equal weight of 30% ethanol solution and stirring for 5 hours, then filtering and sterilizing, the filtrate was distilled under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extract things.

Preferably, the tea extract is prepared by the following method: add tea leaves to water, the weight ratio of tea leaves to water is 1:3, boil for 5 hours, and when cooled to 35-40°C, add yeast with a weight fraction of 0.5% and mix homogeneous, then stand still at 35-40°C for 72 hours, add an equal weight of ethanol solution with a mass fraction of 30% and stir for 4 hours, then filter and sterilize, and the filtrate is distilled under reduced pressure to remove ethanol to obtain the tea extract things.

The preparation method of the above-mentioned mouthwash that can prevent dental caries and oral ulcers includes: adding catechins, grape polyphenols, gingerol, vitamins, folic acid, sweeteners, biological preservatives and biological antibacterial agents into deionized water and stirring evenly , the weight ratio of raw materials to water is 1:3, heat up to 40-50°C, stir for 3 hours, then add chamomile hydrosol, traditional Chinese medicine extract, and tea extract in sequence, stir evenly, and cool down to room temperature to obtain the preventable Mouthwash for caries and mouth sores.

Experimental example

In order to verify the effect of the mouthwash of the present invention, the mouthwash obtained in Examples 1-5 is described in the following experiments.

Test objects: the experimental group is the mouthwash obtained in Examples 1-5, and the control group is 0.9% physiological saline.

1. Antibacterial experiment

Test bacteria: Candida albicans, Streptococcus sanguis, Streptococcus mutans, Actinomyces viscosus, Staphylococcus aureus, Escherichia coli.

Test method: refer to GB15979-2002 Appendix C3 to carry out antibacterial test, antibacterial rate = (number of surviving bacteria in the control group - number of surviving bacteria in the experimental group)/number of surviving bacteria in the control group.

The test results are shown in Table 1.

The antibacterial rate of table 1. embodiment 1-5 gained mouthwash

The test results show that the mouthwash of the present invention has better antibacterial effect on Candida albicans, Streptococcus sanguis, Streptococcus mutans, Actinomyces viscosus, Staphylococcus aureus and Escherichia coli.

2. Anti-inflammatory test

Test method: Take 120 mice and divide them into 6 groups at random, 20 in each group, apply 20ul of xylene to the left ear of the mouse, and 1 hour later, evenly apply 1ml of the mouthwash obtained in Example 1-5 to the inflamed part of the left ear. Once every 30 minutes, for 3 consecutive times, the right ear was left untreated, and the mice were sacrificed 3 hours later, and the ear slices from the same part were weighed to calculate the swelling rate. Swelling rate=(left ear piece weight-right ear piece weight)/right ear piece weight, take the average value, and the results are shown in Table 2.

The anti-inflammatory effect of table 2. embodiment 1-5 gained mouthwash

As can be seen from the data in the table, the mouthwash of the present invention has better anti-inflammatory effect.

Claims (10)

1. A mouthwash that can prevent dental caries and oral ulcers is characterized in that it comprises the following raw materials in parts by weight: 5-10 parts of catechins, 5-10 parts of grape polyphenols, 15-20 parts of gingerols, pure chamomile 8-15 parts of dew, 3-8 parts of vitamin C, 4-10 parts of folic acid, 1-3 parts of sweetener, 15-20 parts of Chinese medicine extract, 10-20 parts of tea extract, the Chinese medicine extract includes the following weight Parts of raw materials: 5-10 parts of Coptis chinensis, 5-10 parts of honeysuckle, 1-5 parts of forsythia, 4-8 parts of Andrographis paniculata, 5-10 parts of licorice, 3-8 parts of gallnut, the tea extract includes the following weight Raw materials for serving: 5-10 servings of green tea, 5-10 servings of oolong tea, 5-10 servings of Kuding tea. 2. The mouthwash capable of preventing dental caries and oral ulcers according to claim 1 is characterized in that it comprises the following raw materials in parts by weight: 9 parts of catechins, 6 parts of grape polyphenols, 15 parts of gingerols, 13 parts of chamomile hydrosol 3 parts of vitamin C, 4 parts of folic acid, 1 part of sweetener, 20 parts of Chinese medicine extract, 20 parts of tea extract. 3. The mouthwash that can prevent dental caries and oral ulcers according to claim 1 is characterized in that, the Chinese medicine extract comprises the following raw materials in parts by weight: 5 parts of Coptis chinensis, 8 parts of honeysuckle, 4 parts of forsythia, 6 parts of Andrographis paniculata 8 parts of licorice, 5 parts of Chinese gall. 4. The mouthwash capable of preventing dental caries and oral ulcers according to claim 1, wherein the tea extract comprises the following raw materials in parts by weight: 10 parts of green tea, 5 parts of oolong tea, and 5 parts of Kuding tea. 5. The mouthwash that can prevent dental caries and oral ulcers according to claim 1 is characterized in that the Chinese medicine extract is prepared by the following method: after mixing the components, they are pulverized to 50 mesh, and added in a weight ratio of 1:2 Mix well with water, then add yeast with a weight fraction of 0.5% and cellulase with a weight fraction of 0.8%, after mixing, ferment at 35°C for 72 hours, add an equal weight of 30% ethanol solution and stir 5h, then filtered and sterilized, and the filtrate was distilled under reduced pressure to remove ethanol to obtain the traditional Chinese medicine extract. 6. The mouthwash capable of preventing dental caries and oral ulcers according to claim 1, wherein the tea extract is prepared by the following method: adding tea leaves to water, the weight ratio of tea leaves and water is 1:3, and boiling for 5 hours , when cooled to 35-40°C, add yeast with a weight fraction of 0.2-0.5% and mix evenly, then stand at 35-40°C for 72h, add an equal weight of ethanol solution with a mass fraction of 30% and stir for 4h, Then filter and sterilize, and the filtrate is distilled under reduced pressure to remove ethanol, so as to obtain the tea extract. 7. The mouthwash capable of preventing dental caries and oral ulcers according to claim 1, characterized in that: the sweetener is aspartame or xylitol. 8. The mouthwash capable of preventing dental caries and oral ulcers according to claim 1, further comprising 0.02 part of biological preservative and 0.1 part of biological antibacterial agent. 9. The mouthwash capable of preventing dental caries and oral ulcers according to claim 8 is characterized in that: said biological preservative is made up of 50wt% potassium sorbate and 50wt% sodium sorbate, and said biological antibacterial agent is chitosan sugar. 10. The preparation method of the mouthwash that can prevent dental caries and oral ulcers as described in any one of claims 1-9, is characterized in that, comprises: catechin, grape polyphenols, gingerol, vitamin, folic acid, sweetener , biological preservatives and biological antibacterial agents are added to deionized water and stirred evenly, the weight ratio of raw materials to water is 1:3, the temperature is raised to 40-50°C, stirred for 3 hours, and then chamomile hydrosol, traditional Chinese medicine extracts, and tea extracts are added in sequence Stir evenly and cool down to room temperature to obtain the mouthwash that can prevent dental caries and oral ulcers.