CN107320428B - Toothpaste for balancing oral micro-ecology - Google Patents
Toothpaste for balancing oral micro-ecology Download PDFInfo
- Publication number
- CN107320428B CN107320428B CN201710582355.XA CN201710582355A CN107320428B CN 107320428 B CN107320428 B CN 107320428B CN 201710582355 A CN201710582355 A CN 201710582355A CN 107320428 B CN107320428 B CN 107320428B
- Authority
- CN
- China
- Prior art keywords
- parts
- toothpaste
- propolis
- extract
- ecology
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000000606 toothpaste Substances 0.000 title claims abstract description 37
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 37
- 241000241413 Propolis Species 0.000 claims abstract description 28
- 229940069949 propolis Drugs 0.000 claims abstract description 28
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920002101 Chitin Polymers 0.000 claims abstract description 18
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 18
- 239000000203 mixture Substances 0.000 claims abstract description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940107628 american ginseng root Drugs 0.000 claims abstract description 11
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229960004711 sodium monofluorophosphate Drugs 0.000 claims abstract description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 8
- 235000011187 glycerol Nutrition 0.000 claims abstract description 8
- 239000000600 sorbitol Substances 0.000 claims abstract description 8
- 235000010356 sorbitol Nutrition 0.000 claims abstract description 8
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims abstract description 7
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims abstract description 7
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims abstract description 7
- XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 claims abstract description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 7
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims abstract description 7
- 239000008367 deionised water Substances 0.000 claims abstract description 7
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 7
- 235000019700 dicalcium phosphate Nutrition 0.000 claims abstract description 7
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 claims abstract description 7
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims abstract description 7
- 229960004029 silicic acid Drugs 0.000 claims abstract description 7
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims abstract description 6
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims abstract description 6
- 229910052731 fluorine Inorganic materials 0.000 claims abstract description 6
- 239000011737 fluorine Substances 0.000 claims abstract description 6
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 claims abstract description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims abstract description 6
- 235000019818 tetrasodium diphosphate Nutrition 0.000 claims abstract description 6
- 240000005373 Panax quinquefolius Species 0.000 claims description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 8
- 238000002386 leaching Methods 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 5
- 229940085605 saccharin sodium Drugs 0.000 claims description 5
- 229930182490 saponin Natural products 0.000 claims description 5
- 150000007949 saponins Chemical class 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000000855 fermentation Methods 0.000 claims description 3
- 230000004151 fermentation Effects 0.000 claims description 3
- 241000228245 Aspergillus niger Species 0.000 claims description 2
- 244000063299 Bacillus subtilis Species 0.000 claims description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 claims description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 2
- 235000011130 ammonium sulphate Nutrition 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 238000001816 cooling Methods 0.000 claims description 2
- ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- 230000036541 health Effects 0.000 abstract description 3
- 206010006326 Breath odour Diseases 0.000 description 11
- 208000032139 Halitosis Diseases 0.000 description 11
- 230000000694 effects Effects 0.000 description 10
- 238000011156 evaluation Methods 0.000 description 8
- 208000007565 gingivitis Diseases 0.000 description 8
- 208000002064 Dental Plaque Diseases 0.000 description 7
- 208000020670 canker sore Diseases 0.000 description 7
- 238000012360 testing method Methods 0.000 description 5
- 208000002399 aphthous stomatitis Diseases 0.000 description 4
- 239000003292 glue Substances 0.000 description 4
- 208000007117 Oral Ulcer Diseases 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 230000003385 bacteriostatic effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000000227 grinding Methods 0.000 description 3
- 210000000214 mouth Anatomy 0.000 description 3
- 239000006072 paste Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 241000222122 Candida albicans Species 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000001680 brushing effect Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 229940095731 candida albicans Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940064222 panax notoginseng root extract Drugs 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 241000186044 Actinomyces viscosus Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000605986 Fusobacterium nucleatum Species 0.000 description 1
- 206010018291 Gingival swelling Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000605862 Porphyromonas gingivalis Species 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 208000008312 Tooth Loss Diseases 0.000 description 1
- 241000589892 Treponema denticola Species 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 230000000675 anti-caries Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000010216 calcium carbonate Nutrition 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 201000001245 periodontitis Diseases 0.000 description 1
- 235000017924 poor diet Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229960001866 silicon dioxide Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 238000009849 vacuum degassing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
- A61K8/988—Honey; Royal jelly, Propolis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/85—Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Zoology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses toothpaste for balancing oral micro-ecology, which is characterized by comprising the following components in parts by mass: 15-20 parts of calcium hydrogen phosphate dihydrate, 20-30 parts of hydrated silica, 20-30 parts of sorbitol, 10-20 parts of glycerol, 1-3 parts of sodium lauryl sulfate, 0.1-1 part of cellulose gum, 0.1-1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, 0.01-0.5 part of tetrasodium pyrophosphate, 0.5-2 parts of an active composition and a proper amount of deionized water, wherein the mass parts of the sodium monofluorophosphate are counted by fluorine; the active composition comprises a American ginseng root extract, a propolis extract and carboxymethyl chitin, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 11-16: 5-9: 0.5 to 0.9. The toothpaste has comprehensive and remarkable efficacy and good biocompatibility, and can balance oral micro-ecology and comprehensively maintain oral health.
Description
Technical Field
The invention relates to toothpaste for balancing oral micro-ecology.
Background
The toothpaste is used as a daily oral cleaning product, comprises common abrasives, a humectant, a thickening agent, a surfactant and the like, and has the basic functions of cleaning the oral cavity, reducing soft dirt and the like. With the increasing working pressure, the influence of poor diet and cleaning habits, people are easy to have oral problems such as gum swelling and pain, bleeding, sensitivity to acid and cold, halitosis and canker sore, the quality of life is affected, and if the oral problems are not treated in time, the oral problems such as periodontitis and even tooth loss are aggravated.
With the benefit of scientific development, more and more research has shown that the most prominent train of leads for oral problems is oral flora imbalance. Oral microorganisms such as Porphyromonas gingivalis, Treponema denticola, Probiota nigricans, Enterobacter, Streptococcus mutans, Actinomyces viscosus, and Fusobacterium nucleatum have been implicated in gingivitis, oral ulcer, and halitosis. There are many kinds of toothpaste with various additives in the market, but there are few toothpaste with complete and obvious efficacy and good biocompatibility. Therefore, the toothpaste focuses on improving the oral micro-ecology, develops the toothpaste which can comprehensively maintain the oral health and simultaneously conforms to the living and working habits of people, and has high market value.
Disclosure of Invention
The invention aims to overcome the defects of the prior art, provides the toothpaste for balancing oral microecology, and solves the problems of single and insignificant effect, low biocompatibility, short shelf life and the like in the background art.
The technical scheme adopted by the invention for solving the technical problems is as follows: 1. the toothpaste for balancing oral micro-ecology is characterized by comprising the following components in parts by mass: 15-20 parts of calcium hydrogen phosphate dihydrate, 20-30 parts of hydrated silica, 20-30 parts of sorbitol, 10-20 parts of glycerol, 1-3 parts of sodium lauryl sulfate, 0.1-1 part of cellulose gum, 0.1-1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, 0.01-0.5 part of tetrasodium pyrophosphate, 0.5-2 parts of an active composition and a proper amount of deionized water, wherein the mass parts of the sodium monofluorophosphate are counted by fluorine;
the active composition comprises a American ginseng root extract, a propolis extract and carboxymethyl chitin, wherein the molecular weight of the carboxymethyl chitin is 2-5 ten thousand.
In a preferred embodiment of the present invention, the mass ratio of the panax notoginseng root extract, the propolis extract and the carboxymethyl chitin is 11-16: 5-9: 0.5 to 0.9.
In a preferred embodiment of the present invention, the preparation method of the american ginseng extract comprises: extracting radix Panacis Quinquefolii to obtain saponin, drying, pulverizing, adding appropriate amount of aqueous solution containing ammonium sulfate and dipotassium hydrogen phosphate, mixing, sterilizing, inoculating mixed zymocyte seed solution of Aspergillus niger and Bacillus subtilis, fermenting for 20 days, terminating fermentation, and sterilizing.
In a preferred embodiment of the present invention, the preparation method of the propolis extract comprises: adding crude propolis into 7 times of boiling water, stirring for 3 hr, cooling to 22-25 deg.C, and removing wax layer and water layer to obtain wax-removed propolis; extracting wax-removed propolis with 8 times of 70% ethanol at constant temperature of 60 deg.C for 3 times, each time for 2 hr. Combining the leaching liquor for 3 times, and mixing the propolis leaching liquor: preparing the propolis extract according to the water mass ratio of 1: 10.
In a preferred embodiment of the present invention, the composition further comprises 0.01 to 0.1 part of saccharin sodium.
In a preferred embodiment of the present invention, the composition further comprises 0.05 to 0.5 parts of a preservative.
In a preferred embodiment of the present invention, the liquid composition further comprises 0.01 to 0.05 parts of essence.
In a preferred embodiment of the present invention, the mass ratio of the panax notoginseng root extract, the propolis extract and the carboxymethyl chitin is 11: 5: 0.5.
compared with the background technology, the technical scheme has the following advantages:
1. american ginseng is widely used in the world as a precious Chinese medicinal material, but is more directed to the application of saponin contained in the American ginseng. However, the American ginseng has other beneficial components such as saccharides besides saponin, and researches show that the American ginseng after extracting the saponin component can obtain the active component of the American ginseng oligosaccharide through specific fermentation conditions.
2. The propolis extract and the carboxymethyl chitin are matched with the American ginseng extract to enhance the bacteriostatic effect of the product on candida albicans. The propolis extract and the carboxymethyl chitin with low molecular weight have bacteriostatic ability on candida albicans, but the minimum bacteriostatic concentration of the propolis extract is higher than that of the carboxymethyl chitin with low molecular weight, and the taste is not pleasant. The three components are matched according to proper proportion through repeated experiments, and the comprehensiveness and the significance of the efficacy of the toothpaste are greatly improved.
3. The active composition is extracted from nature, animals and plants by combining modern biotechnology, has good biodegradability and biocompatibility, is suitable for proportion matching, and greatly increases the comprehensiveness and significance of the efficacy of the toothpaste.
Detailed Description
The present invention will be described in detail with reference to the following examples:
example 1
A toothpaste for balancing oral microecology comprises 18% of calcium hydrogen phosphate dihydrate, 25% of hydrated silica, 23% of sorbitol, 12% of glycerol, 1% of sodium lauryl sulfate, 0.3% of cellulose gum, 0.3% of hydroxyethyl cellulose, 0.06% of sodium saccharin, 0.1% of sodium monofluorophosphate (calculated by fluorine), 0.05% of tetrasodium pyrophosphate, 1% of active composition, 0.05% of essence, 0.4% of sodium benzoate and the balance of deionized water. Wherein the American ginseng root extract: propolis extract: the mass ratio of the carboxymethyl chitin is 11: 5: 0.5.
1) weighing the raw materials according to the formula dosage of 1000g for later use;
2) putting sorbitol, glycerol, cellulose gum and hydroxyethyl cellulose into a glue pot, wetting and stirring, adding the dissolved saccharin sodium, deionized water and other raw materials, continuously stirring to enable the prepared glue to be in a uniform, semitransparent and sticky liquid state, and then storing to enable the glue to be fully dissolved and expanded for use;
3) adding the active composition, the various solid powdery raw materials, the prepared glue, essence and the like into a blocking pot according to the formula and operation requirements, and mechanically mixing and uniformly stirring to prepare a paste with certain viscosity and proper thickness;
4) grinding the paste by a grinder, grinding coarse and hard particles to make the paste fine, uniform and stable, vacuum degassing after grinding, and standing for a period of time to obtain the product.
The toothpaste of this example was taken for evaluation experiments:
(1) the toothpaste efficacy clinical evaluation for inhibiting dental plaque and relieving gingivitis.
By adopting a random and double-blind test method, a test group is the toothpaste prepared in the embodiment (marked as group A), a control group is the China double-calcium anti-caries toothpaste produced by the company Rihua Limited (marked as group B), a clinical examination indicates dental plaque (Q-H dental plaque index, P L I) and gingivitis (gingival index, GI), the two training elements are all the same, and an oral cavity treating doctor skilled in operation performs oral cavity examination, and after screening for 150 people, subjects use the corresponding toothpaste and toothbrush respectively, and review the corresponding indexes after 1 week, 3 months and 6 months respectively to evaluate the effect.
In the test process, 14 people are rejected because toothpaste is not used according to the test requirement, and finally 136 people complete the test in the whole 6 months and are included in the statistical analysis. The test results are shown in tables 1 and 2.
TABLE 1 evaluation of dental plaque
The results show that the mean plaque index of the subjects was statistically significant (P < 0.05) between the two groups using this example and the control.
TABLE 2 evaluation of gingivitis
The results show that the mean of the gingival indices of the subjects at month 3 and month 6 are statistically significant (P < 0.05) in the differences between the use of this example and the control.
From the above two results, the toothpaste prepared in this example has better plaque reduction and gingivitis reduction effects than the zhonghua double calcium toothpaste. The formula tables of the two are analyzed to show that the formulas of the two are basically consistent except for the active composition, which indicates that the toothpaste efficacy can be obviously improved by adding the active composition.
(2) Evaluation of halitosis and canker sore effects.
Because the subjective judgment of the change of halitosis and oral ulcer is strong, the evaluation adopts the subjective judgment of the testee. The halitosis person 25 and the canker sore person 31 require brushing their teeth in the morning and evening, brushing their tongue with the toothbrush 5 times, and judging after 10 days. The results are shown in Table 3.
TABLE 3 halitosis and canker sore Effect
| Has the effects of | Effective but not obvious | Without effect | |
| Improving halitosis | 19 | 3 | 3 |
| Improving oral ulcer | 26 | 2 | 3 |
The results show that more than half of the subjects think that the toothpaste prepared by the embodiment can improve halitosis and canker sore. The effect of the product as a product for daily maintenance of oral health is proved.
Example 2
Example 2 differs from example 1 in that: the toothpaste of this example comprises 20% of dibasic calcium phosphate dihydrate, 20% of hydrated silica, 30% of sorbitol, 20% of glycerin, 2% of sodium lauryl sulfate, 0.1% of cellulose gum, 0.1% of hydroxyethyl cellulose, 0.03% of sodium saccharin, 0.1% of sodium monofluorophosphate (calculated as fluorine), 0.0.01% of tetrasodium pyrophosphate, 0.5% of an active composition, 0.03% of an essence, 0.5% of sodium benzoate, and the balance of deionized water. The active composition consists of a American ginseng root extract, a propolis extract and carboxymethyl chitin, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 13:9: 0.7.
According to clinical evaluation, the toothpaste of the embodiment can inhibit dental plaque, relieve gingivitis, and reduce halitosis and canker sore.
Example 3
Example 3 differs from example 1 in that: in the toothpaste of the present embodiment, the calcium hydrogen phosphate dihydrate is 15%, the hydrated silica is 30%, the sorbitol is 20%, the glycerol is 10%, the sodium lauryl sulfate is 3%, the cellulose gum is 1%, the hydroxyethyl cellulose is 1%, the saccharin sodium is 0.05%, the sodium monofluorophosphate is 0.1% (calculated by fluorine), the tetrasodium pyrophosphate is 0.5%, the active composition is 2.0%, the essence is 0.05%, the sodium benzoate is 0.5%, and the balance is deionized water. The active composition consists of a American ginseng root extract, a propolis extract and carboxymethyl chitin, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 16:7: 0.9.
According to clinical evaluation, the toothpaste of the embodiment can inhibit dental plaque, relieve gingivitis, and reduce halitosis and canker sore.
It will be appreciated by those skilled in the art that the same or similar technical effects as those of the above embodiments can be expected when the technical parameters of the present invention are changed within the following ranges:
calcium hydrogen phosphate dihydrate and hydrated silica are used as abrasive of toothpaste, and are replaced by at least one of calcium carbonate, calcium hydrogen phosphate, silicon dioxide, aluminum hydroxide, etc.
Glycerin and sorbitol are used as toothpaste humectant and are replaced by propylene glycol and the like.
Saccharin sodium is sweetener, and is replaced by xylitol.
The above embodiments can achieve the effects of the following experimental examples:
the compound preparation can effectively inhibit dental plaque, and the Q-H plaque index Mean plus or minus SD is obviously reduced after being used for one week; gingivitis is improved, and the gingival index Mean plus or minus SD is effectively improved along with the increase of the using time; the majority of subjects had symptomatic relief of halitosis and canker sores.
The above description is only a preferred embodiment of the present invention, and therefore should not be taken as limiting the scope of the invention, which is defined by the appended claims and their equivalents.
Claims (6)
1. The toothpaste for balancing oral micro-ecology is characterized by comprising the following components in parts by mass: 15-20 parts of calcium hydrogen phosphate dihydrate, 20-30 parts of hydrated silica, 20-30 parts of sorbitol, 10-20 parts of glycerol, 1-3 parts of sodium lauryl sulfate, 0.1-1 part of cellulose gum, 0.1-1 part of hydroxyethyl cellulose, 0.1 part of sodium monofluorophosphate, 0.01-0.5 part of tetrasodium pyrophosphate, 0.5-2 parts of an active composition and a proper amount of deionized water, wherein the mass parts of the sodium monofluorophosphate are counted by fluorine;
the active composition comprises a American ginseng root extract, a propolis extract and carboxymethyl chitin, wherein the molecular weight of the carboxymethyl chitin is 2-5 ten thousand, and the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is (11-16): 5-9: 0.5 to 0.9;
the preparation method of the American ginseng extract comprises the following steps: extracting radix Panacis Quinquefolii to obtain saponin, drying, pulverizing, adding appropriate amount of aqueous solution containing ammonium sulfate and dipotassium hydrogen phosphate, mixing, sterilizing, inoculating mixed zymocyte seed solution of Aspergillus niger and Bacillus subtilis, fermenting for 20 days, terminating fermentation, and sterilizing.
2. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: the preparation method of the propolis extract comprises the following steps: adding crude propolis into 7 times of boiling water, stirring for 3 hr, cooling to 22-25 deg.C, and removing wax layer and water layer to obtain wax-removed propolis; taking wax-removed propolis, leaching with 8 times of 70% ethanol at constant temperature of 60 deg.C for 3 times, each time for 2 hr, mixing 3 times of leaching solutions, and mixing the leaching solutions according to the weight ratio of propolis leaching solution: preparing the propolis extract according to the water mass ratio of 1: 10.
3. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: and 0.01-0.1 part of saccharin sodium.
4. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: also comprises 0.05-0.5 part of preservative.
5. The toothpaste for balancing oral micro-ecology according to claim 1, wherein: also comprises 0.01 to 0.05 portion of essence.
6. A toothpaste for balancing the oral micro-ecology according to any one of claims 1 to 5, wherein: the mass ratio of the American ginseng root extract to the propolis extract to the carboxymethyl chitin is 11: 5: 0.5.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710582355.XA CN107320428B (en) | 2017-07-17 | 2017-07-17 | Toothpaste for balancing oral micro-ecology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710582355.XA CN107320428B (en) | 2017-07-17 | 2017-07-17 | Toothpaste for balancing oral micro-ecology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107320428A CN107320428A (en) | 2017-11-07 |
| CN107320428B true CN107320428B (en) | 2020-07-28 |
Family
ID=60227278
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710582355.XA Active CN107320428B (en) | 2017-07-17 | 2017-07-17 | Toothpaste for balancing oral micro-ecology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107320428B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110090188A (en) * | 2019-05-08 | 2019-08-06 | 广州淡韵生物科技有限公司 | A kind of Chinese medicinal toothpaste and preparation method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1969801A (en) * | 2005-11-25 | 2007-05-30 | 王立君 | Application of water soluble chitosan in toothpaste and mouthwash |
| CN102283794B (en) * | 2011-08-22 | 2013-07-24 | 昆明振华制药厂有限公司 | Toothpaste including radix notoginseng and propolis and preparation method thereof |
| CN104013657B (en) * | 2014-01-16 | 2017-08-04 | 金日制药（中国）有限公司 | A kind of American ginseng medicine extracts after saponin(e microbial fermentation extracting method again |
-
2017
- 2017-07-17 CN CN201710582355.XA patent/CN107320428B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN107320428A (en) | 2017-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104800261B (en) | A kind of cloves compound mouthwash | |
| CN107281013B (en) | Toothpaste for removing tooth stain and inhibiting dental plaque | |
| CN107595750B (en) | Active anti-inflammation toothpaste | |
| CN107468553B (en) | Dental caries prevention toothpaste | |
| CN110101638A (en) | A kind of anti-inflammatory antiallergy toothpaste | |
| WO2023284221A1 (en) | Composition with soothing and repairing effects, and preparation method therefor and use thereof | |
| CN107496329A (en) | One kind compounding natural whiting toothpaste and preparation method thereof | |
| CN115721594B (en) | Toothpaste containing ginkgo extract and preparation method thereof | |
| CN108030749B (en) | Medical seaweed toothpaste | |
| CN107362121A (en) | A kind of anti-inflammatory antiulcer toothpaste of American-cockroach-extract-containing | |
| CN107320428B (en) | Toothpaste for balancing oral micro-ecology | |
| CN104983806B (en) | A kind of Chinese medicine composition for treating mouth disease, preparation method and applications | |
| CN112294687A (en) | Black tea fungus fermentation mask liquid and preparation method thereof | |
| CN107362112B (en) | Gum-protecting and healing toothpaste | |
| AU2016225938A1 (en) | Compositions and methods for the prevention and treatment of oral diseases | |
| CN115919686A (en) | Skin soothing lotion for enhancing skin barrier and preparation method thereof | |
| CN106551850A (en) | A kind of promoting and tooth-building toothpaste | |
| CN109846794B (en) | Composition, microsphere containing composition and preparation method of microsphere | |
| CN115364016B (en) | Toothpaste with periodontal disease improving effect and preparation method thereof | |
| KR20170090717A (en) | Mouthwash | |
| KR20150047704A (en) | A toothpaste composition comprising non-toxic mineral sulfur and a method for preparation thereof | |
| CN105362118B (en) | A kind of maca health-care toothpaste and preparation method | |
| US11771644B1 (en) | Whitening toothpaste capable of effectively removing dental plaque and tartar | |
| CN118217214B (en) | An antiinflammatory and antibacterial toothpaste containing bisabolol and rhizoma Zingiberis recens, and its preparation method | |
| CN115919712B (en) | Preparation method and application of Chinese herbal medicine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |