CN107281013B - Toothpaste for removing tooth stain and inhibiting dental plaque - Google Patents
Toothpaste for removing tooth stain and inhibiting dental plaque Download PDFInfo
- Publication number
- CN107281013B CN107281013B CN201710636332.2A CN201710636332A CN107281013B CN 107281013 B CN107281013 B CN 107281013B CN 201710636332 A CN201710636332 A CN 201710636332A CN 107281013 B CN107281013 B CN 107281013B
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- Prior art keywords
- toothpaste
- cordyceps militaris
- inhibiting
- plaque
- dental
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
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- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/817—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen; Compositions or derivatives of such polymers, e.g. vinylimidazol, vinylcaprolactame, allylamines (Polyquaternium 6)
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- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A61Q17/005—Antimicrobial preparations
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Abstract
The invention discloses toothpaste for removing tooth stains and inhibiting dental plaque, which comprises cordyceps militaris essence, O-cymene-5-ol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone. The toothpaste for removing tooth stains and inhibiting dental plaque contains multiple functional components such as cordyceps militaris essence, O-cymene-5-alcohol, potassium nitrate, sodium phytate, zinc citrate, polyvinylpyrrolidone and the like, and the cordyceps militaris essence is matched with mild and non-irritant bacteriostatic stain-removing factors and antibacterial factors, so that the toothpaste can effectively inhibit the adhesion and aggregation of oral bacteria, simultaneously remove color stains and dirt on the surfaces of teeth, and has the effects of astringency and sensitivity relief. The functional components of the invention can remove dental stain and inhibit the formation of dental plaque fundamentally under the synergistic effect, thereby achieving the effects of nursing oral cavity and whitening teeth. The toothpaste for removing tooth stains and inhibiting dental plaque can remove tooth stains and whiten teeth and prevent oral diseases such as periodontitis, gingivitis, dental calculus, caries and the like after being used for a long time.
Description
Technical Field
The invention relates to toothpaste, in particular to toothpaste for removing tooth stains and inhibiting dental plaque.
Background
Along with the enhancement of consciousness of people on health and the improvement of life quality, the attention degree of oral care is greatly enhanced. Most diseases of human are caused by oral cavity, and the maintenance of oral hygiene is an important link for preventing diseases, and the key for maintaining oral hygiene is to maintain the hygiene of teeth. If teeth are unsanitary, a large amount of microorganisms are propagated therein, and corrode teeth, causing halitosis, gingival swelling, etc., and more serious dental diseases may also cause other serious systemic diseases.
Dental plaque is an ecological environment of bacteria present on the tooth surface or in the periodontal pocket, where bacteria grow, develop and die, and undergo complex metabolic activities, under certain conditions, the bacteria and their products will destroy the teeth and periodontal tissues. Plaque is a soft, unmineralized bacterial plaque that adheres to the tooth surface and is not easily detectable in small quantities. However, as time goes on, the plaque is not removed in time, which can cause stubborn spots and stains which can not be removed by daily oral care, and the tooth surface loses luster and becomes yellow and dark. Thus, effective removal of plaque is very important to prevent the development of plaque and related oral diseases.
Disclosure of Invention
The invention aims to overcome the defects in the prior art and provide toothpaste for removing tooth stains and inhibiting dental plaque.
In order to achieve the purpose, the invention adopts the technical scheme that: a toothpaste for removing dental stain and inhibiting dental plaque comprises scarlet caterpiller fungus essence, O-cymene-5-ol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone; the Cordyceps militaris essence is a mixture of Cordyceps militaris extract and Cordyceps militaris fruiting body.
The cordyceps militaris is edible fungus for both food and medicine, and the cordyceps militaris extract can be purchased in the market and can also be a refined extract obtained by carrying out water extraction and alcohol precipitation on cordyceps militaris fruiting bodies. The Cordyceps militaris fruiting body is obtained by inoculating Cordyceps militaris strain on solid culture medium, culturing for a certain period of time, developing and differentiating mycelium to form orange rod-shaped stroma (fruiting body), collecting fresh fruiting body, air drying, and grinding; the fruiting body powder is refined after water extraction and alcohol precipitation, and effective components such as cordycepin, adenosine, cordycepic acid, polysaccharide, SOD enzyme and the like are efficiently concentrated, especially the effective components of cordycepin.
The cordyceps militaris sporocarp provided by the invention is composed of substances such as water, ash, protein and fat, contains various volatile compounds, contains more aromatic aldehyde substances, and has certain antibacterial and anti-inflammatory effects, but the aromatic volatile components cannot be retained for more than one hour at the extraction temperature of 50 ℃. Therefore, the effective components in the cordyceps militaris sporocarp are difficult to keep in the refining, heating and purifying processes, so that the volatile components of the cordyceps militaris sporocarp can completely enter a toothpaste system by adding the cordyceps militaris sporocarp.
Cordycepin, the first nucleoside antibiotic separated from fungi, has a molecular structure of 3-deoxyadenosine, has a broad-spectrum antibacterial effect, and is found to be capable of inhibiting the growth of pathogenic bacteria such as streptococcus, staphylococcus and the like, and has strong antiviral activity, so that the cordycepin has natural antibacterial, anti-inflammatory and antiviral effects in a toothpaste formula. Because the cordycepin is the main antibacterial component in the cordyceps militaris extract, the content of the cordycepin in the toothpaste formula is directly influenced by the addition amount of the cordyceps militaris essence.
The invention uses the cordyceps militaris sporocarp and the cordyceps militaris extract, so that the system contains various functional components such as cordycepin, cordycepic acid, polysaccharide, SOD enzyme and the like, and also contains the volatile components of the cordyceps militaris sporocarp per se, thereby the gum and tooth protecting effects are exerted to the best.
O-cymene-5-alcohol is a broad-spectrum bactericide, has strong penetration sterilization effect, has good antibacterial effect on staphylococcus aureus, porphyromonas gingivalis and oral pathogenic bacteria, can penetrate into dental plaque to sterilize, is suitable for inflammation patients of gingivitis, periodontitis and the like, and can select commercially available products, such as Isopropyl methyl phenol of Nanjing Sbyaceae Biochemical industry Limited company.
Potassium nitrate, a desensitizing active ingredient in the United states Food and Drug Administration (FDA) monograph for tooth desensitization products, releases potassium ions, prevents the nerve endings of the dentinal tubules from being activated, and at sufficient potassium ion concentrations, prevents the nerve from being stimulated by the compressed dentin, reduces the permeability of the dentin, and thereby slows down dentin hypersensitivity.
The salt derivatives of sodium phytate and phytic acid have good chelating and swelling effects on various color stains, form water-soluble composite salt with stains, and are easy to fall off and brush off in the process of tooth brushing, so that the stains on teeth are effectively removed, and the stains can be prevented from being deposited and attached on the surfaces of the teeth again.
The zinc salt has the property of convergence, and when the water-soluble zinc salt is applied to a toothpaste formula, the provided zinc ions can prevent the formation of bacterial deposits, so that the effects of reducing the accumulation of dental plaque and dental calculus are achieved, and meanwhile, the deposition and adhesion of color stains such as smoke stains on the surface of teeth are prevented, so that the effects of stain removal and whitening are achieved. The zinc citrate selected by the invention is slightly soluble in water, can gradually release zinc ions, and can act on tissues such as gingiva and the like for a long time.
Polyvinylpyrrolidone (PVP), a non-ionic polymeric compound, is capable of improving its solubility in water by chelating stain materials, thereby effectively removing stains on teeth. Due to the unique stain removing principle, PVP is a novel gum protecting and whitening agent without friction whitening and oxidation whitening, and cannot cause stimulation to teeth.
The toothpaste for removing dental stains and inhibiting dental plaque disclosed by the invention is applied by combining cordyceps militaris essence, an antibacterial stain-removing factor and an anti-sensitivity factor together, can effectively inhibit adhesion and aggregation of oral bacteria, simultaneously removes color stains and dirt on the surfaces of teeth, and also has the effects of astringing and relieving sensitivity. The whitening principle of the toothpaste for removing tooth stains and inhibiting dental plaque is different from that of a stimulating whitening method by using peroxide, the peroxide is decomposed by reaction in water, the stimulation to oral mucosa is large, the peroxide component can be applied only by a formula with little water, otherwise, tube expansion is failed in a short time, and the system cannot be stable. On the contrary, the cordyceps militaris essence, the O-cymene-5-ol, the potassium nitrate, the sodium phytate, the zinc citrate and the polyvinylpyrrolidone contained in the toothpaste for removing dental stains and inhibiting dental plaques have mild and non-irritant functional components, can effectively inhibit bacteria and prevent bacteria from being adhered to teeth, are stably compatible, and are more suitable for being applied in a toothpaste formula, and the functional components can synergistically resist the formation of dental plaques, so that the effects of caring and whitening the teeth are achieved.
Preferably, the tooth stain removal and inhibition toothpaste comprises the following preparation raw materials in percentage by weight: 0.1-5% of cordyceps militaris essence, 0.05-0.1% of O-cymene-5-alcohol, 3-10% of potassium nitrate, 0.2-2% of sodium phytate, 0.25-2% of zinc citrate and 0.25-2% of polyvinylpyrrolidone.
Repeated research by the inventor shows that when the content of the cordyceps militaris essence is lower than 0.1%, the antibacterial effect is not obvious, and the antibacterial effect is enhanced along with the increase of the content of the cordyceps militaris essence, but when the content of the cordyceps militaris essence is higher than 5%, the antibacterial effect is not obviously increased along with the increase of the addition amount of the cordyceps militaris essence, and when the content of the cordyceps militaris essence is 0.1-5%, the cordyceps militaris essence has a good antibacterial effect; when the components are matched with each other in the proportion, the antibacterial effect and the effect of removing the dental stain are obviously enhanced, and the antibacterial tooth stain can effectively remove the dental stain, whiten the teeth and inhibit the generation of dental plaque.
More preferably, the tooth stain removal and inhibition toothpaste comprises the following preparation raw materials in percentage by weight: 0.5-3% of cordyceps militaris essence, 0.05-0.08% of O-cymene-5-alcohol, 3-5% of potassium nitrate, 0.2-1% of sodium phytate, 0.5-1.5% of zinc citrate and 0.25-1% of polyvinylpyrrolidone.
Through repeated research of the inventor, when the components are in the content, the toothpaste disclosed by the invention can effectively inhibit the adhesion and aggregation of oral bacteria, remove color stains and dirt on the surfaces of teeth, and has the best effect of removing the stains and inhibiting the formation of dental plaque by each functional component.
Preferably, the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body 80-99.9: 0.01 to 20.
When the cordyceps militaris extract and the cordyceps militaris sporocarp are in the weight ratio, the cordyceps militaris extract and the cordyceps militaris sporocarp can fully exert respective effects, so that a system contains cordycepin, cordycepic acid, polysaccharide, SOD enzyme and various volatile compounds, and the effects of gum and tooth protection are achieved.
More preferably, the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: 8-15.
When the cordyceps militaris extract and the cordyceps militaris sporocarp are in the weight ratio, the toothpaste achieves the best sterilization effect.
Preferably, the raw materials for preparing the tooth stain removal and inhibition toothpaste further comprise a humectant, an abrasive, a thickener and a foaming agent.
Preferably, in the preparation raw materials of the toothpaste for removing tooth stains and inhibiting dental plaque, the humectant accounts for 30-50 wt%, the abrasive accounts for 16-40 wt%, the thickener accounts for 0.5-3 wt%, and the foaming agent accounts for 1.8-3 wt%.
Preferably, the foaming agent is a mixture of sodium lauryl sulfate and at least one of an amino acid surfactant and an amphoteric surfactant.
More preferably, the foaming agent is a mixture of sodium lauryl sarcosinate, sodium lauroyl methyltaurate and cocamidopropyl betaine with sodium lauryl sulfate.
When the foaming agent only uses the sodium dodecyl sulfate, the foaming agent has less and sparse foam and slightly poor mouth feel during tooth brushing, and when the foaming agent is matched with at least one of the amino acid surfactant and the amphoteric surfactant, the foaming speed can be increased, the foam is fine and rich, and the problem of dry and astringent mouth feel without foam is solved. The foaming agents are all selected from commercially available products, for example, sodium lauroyl sarcosinate can be selected from OLI-4208 of Olympic, sodium lauroyl methyltaurate can be selected from OLI-4901 of Olympic, cocamidopropyl betaine can be selected from CAPB DC of Galaxy Surfactants, and Lenotain C30 of Olympic, of which CAPB DC is particularly suitable.
Preferably, the abrasive is at least one of precipitated silica, ultrafine silica, calcium hydrogen phosphate, and calcium carbonate.
More preferably, the abrasive is a mixture of at least one of precipitated silica, calcium hydrogen phosphate and calcium carbonate and ultrafine silica, wherein the ultrafine silica accounts for 2-6 wt% of the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste.
The weight percentage of the superfine silicon dioxide in the preparation raw materials of the toothpaste is 2-6%. When the dosage of the superfine silicon dioxide is less than 2 percent, the surface of the paste body is not smooth, the mouth feel of tooth brushing is poor, and when the dosage of the superfine silicon dioxide is more than 6 percent, the paste body is easy to harden and go out of water at high temperature, so that the stability is influenced. The amount of the ultrafine silica absorbed is 30 to 44ml/20g, preferably 30 to 38ml/20g, and commercially available products such as general silica from the company Town can be used. The amount of the precipitated silica sucked is 15 to 25ml/20g, preferably 18 to 22ml/20g, and commercially available products such as Zeodent115 from HUBER can be used. The amount of calcium hydrogen carbonate absorbed is 5.0 to 6.5mL/20g, the apparent density is 0.80 to 1.00g/mL, the amount of absorbed liquid is preferably maximized and the apparent density is minimized, and commercially available products such as toothpaste grade calcium hydrogen phosphate from Depont may be used. The amount of calcium carbonate absorbed is 3.8 to 5.0ml/20g, preferably 3.8 to 4.2ml/20g, and commercially available products such as calcite powder from the company Mintellian can be used.
Preferably, the thickener is at least one of sodium carboxymethylcellulose, carbomer and xanthan gum; the humectant is at least one of sorbitol, glycerol, polyethylene glycol and propylene glycol.
The sodium carboxymethylcellulose is commercially available, such as TH10 (toothpaste grade) from ASHLAND, and has a substitution degree of 0.75-1.02, preferably 0.95-1.02, and a 2% aqueous solution viscosity of 600-3000 mPas, preferably 1200-2500 mPas. Carbomers can be selected from the commercial products, for example from the Lubrizol company
POLYMER (toothpaste grade), adjusted to pH around 7 (within the range of 6.5-7.5) with 25% NaOH solution, measured at 20rpm with Brookfield RV6 spindle, viscosity of 0.6% neutralized aqueous solution: 15000 to 40000 mPas, preferably 20000 to 30000 mPas. Xanthan gum, also known as xanthan gum, is commercially available, e.g. from CPKelco
Xanthan Gum (oral grade) with a viscosity of 1200-1600 mPas measured in a 1% KCl solution at 20rpm with a Brookfield RV6 rotor.
In addition to the specific requirements of the components, the toothpaste for removing tooth stains and inhibiting dental plaque can be added or used with other auxiliary materials within the range of not damaging the effect of the invention, the auxiliary materials can be sweeteners, pH regulators, spices, coloring agents, fluorides and the like, and the ordinary content can be selected by a person skilled in the art according to the conventional standard.
Preferably, the dental stain removal and inhibition toothpaste further comprises the following components in percentage by mass: 0.1-2% of sweetening agent, 0.1-3% of pH regulator and 0.1-2% of spice.
Preferably, the sweetener is at least one of sodium saccharin, sucralose, and stevia; the spice is at least one of menthol, peppermint oil, spearmint oil, wintergreen oil, peppermint, sweet orange oil, lemon oil, anise oil and eucalyptus oil; the pH regulator is at least one of sodium hydroxide, anhydrous trisodium phosphate, sodium tripolyphosphate, alkaline phosphate and sodium dihydrogen phosphate.
The preparation method of the toothpaste for removing tooth stains and inhibiting dental plaque comprises the following steps:
(1) pre-dissolving potassium nitrate and auxiliary materials;
(2) premixing the friction agent and the thickening agent;
(3) adding the humectant and the materials in the step (1) into a paste preparation tank;
(4) opening a vacuum system of the paste making tank, vacuumizing, adding the mixture obtained in the step (2), cordyceps militaris essence, O-cymene-5-ol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone, and stirring and homogenizing under the condition of keeping the vacuum between-0.05 Mpa and-0.085 Mpa;
(5) adding foaming agent into the paste preparation tank, keeping the vacuum between-0.05 Mpa and-0.085 Mpa, and continuously stirring and homogenizing;
(6) degassing the paste preparation tank until the vacuum degree is-0.092 Mpa to-0.098 Mpa, and discharging paste to obtain the toothpaste for removing dental stain and inhibiting dental plaque.
The invention has the beneficial effects that: the invention provides a toothpaste for removing tooth stains and inhibiting dental plaque, which contains multiple functional components such as cordyceps militaris essence, O-cymene-5-alcohol, potassium nitrate, sodium phytate, zinc citrate, polyvinylpyrrolidone and the like, wherein the cordyceps militaris essence is matched with mild and non-irritant bacteriostatic stain-removing factors, so that the adhesion and aggregation of oral bacteria can be effectively inhibited, and meanwhile, color stain dirt on the surface of teeth is removed, and each functional component can synergistically and fundamentally remove the tooth stains and inhibit the formation of the dental plaque, has the effects of astringing and relieving allergy, and achieves the effects of nursing the oral cavity and whitening the teeth. The toothpaste for removing tooth stains and inhibiting dental plaque can remove tooth stains and whiten teeth and prevent oral diseases such as periodontitis, gingivitis, dental calculus, caries and the like after being used for a long time.
Drawings
FIG. 1 is a comparison graph of the bacteriostasis test of the toothpastes of example 5 and comparative examples 1-6 on staphylococcus aureus;
FIG. 2 is a comparison graph of the bacteriostatic tests of the toothpastes of example 5 and comparative examples 1-6 on Streptococcus mutans;
FIG. 3 is a comparison chart of the bacteriostasis test of the toothpastes of example 5 and comparative examples 1-6 on the porphyromonas gingivalis.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Example 1
The invention discloses an embodiment of toothpaste for removing tooth stains and inhibiting dental plaque, which comprises the following preparation raw materials in percentage by weight: 0.1% of cordyceps militaris essence, 0.01% of O-cymene-5-alcohol, 3% of potassium nitrate, 0.2% of sodium phytate, 0.25% of zinc citrate, 0.25% of polyvinylpyrrolidone, 50% of humectant, 16% of abrasive, 0.5% of thickening agent, 1.8% of foaming agent, 0.1% of sweetening agent, 0.1% of pH regulator, 0.1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 99.9: 0.01; the humectant is sorbitol; the thickening agent is sodium carboxymethyl cellulose; the foaming agent is a mixture of sodium lauroyl sarcosinate and sodium dodecyl sulfate; the mixture of the abrasive precipitated silica and the superfine silica is prepared, wherein the weight percentage of the superfine silica in the raw materials for preparing the toothpaste for removing tooth stains and inhibiting dental plaque is 2%; the sweetener is saccharin sodium; the spice is menthol; the pH regulator is alkaline phosphate and sodium dihydrogen phosphate.
Example 2
The invention discloses an embodiment of toothpaste for removing tooth stains and inhibiting dental plaque, which comprises the following preparation raw materials in percentage by weight: 5% of cordyceps militaris essence, 0.1% of O-cymene-5-alcohol, 10% of potassium nitrate, 2% of sodium phytate, 2% of zinc citrate, 2% of polyvinylpyrrolidone, 30% of humectant, 30% of abrasive, 3% of thickening agent, 3% of foaming agent, 2% of sweetener, 3% of pH regulator, 2% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 80: 20; the humectant is a mixture of sorbitol and glycerol; the thickening agent is a mixture of sodium carboxymethylcellulose and carbomer; the foaming agent is a mixture of sodium lauroyl methyl taurate and sodium dodecyl sulfate; the abrasive is a mixture of calcium hydrophosphate and ultrafine silicon dioxide, and the weight percentage of the ultrafine silicon dioxide in the raw materials for preparing the toothpaste for removing tooth stains and inhibiting dental plaque is 6%; the sweetener is sucralose; the spice is spearmint oil; the pH regulator is sodium hydroxide.
Example 3
The invention discloses an embodiment of toothpaste for removing tooth stains and inhibiting dental plaque, which comprises the following preparation raw materials in percentage by weight: 0.5% of cordyceps militaris essence, 0.05% of O-cymene-5-alcohol, 3% of potassium nitrate, 0.2% of sodium phytate, 0.5% of zinc citrate, 0.25% of polyvinylpyrrolidone, 40% of humectant, 40% of abrasive, 0.5% of thickening agent, 1.8% of foaming agent, 0.1% of sweetening agent, 0.1% of pH regulator, 0.1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 92: 8; the humectant is a mixture of sorbitol and propylene glycol; the thickening agent is a mixture of sodium carboxymethylcellulose and xanthan gum; the foaming agent is a mixture of cocamidopropyl betaine and sodium lauryl sulfate; the abrasive is a mixture of calcium carbonate and superfine silicon dioxide, and the weight percentage of the superfine silicon dioxide in the raw materials for preparing the toothpaste for removing tooth stains and inhibiting dental plaque is 4%; the sweetener is stevia rebaudiana; the spice is lemon oil; the pH regulator is anhydrous trisodium phosphate.
Example 4
The invention discloses an embodiment of toothpaste for removing tooth stains and inhibiting dental plaque, which comprises the following preparation raw materials in percentage by weight: 3% of cordyceps militaris essence, 0.08% of O-cymene-5-alcohol, 5% of potassium nitrate, 1% of sodium phytate, 1.5% of zinc citrate, 1% of polyvinylpyrrolidone, 45% of humectant, 20% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 85: 15; the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 6%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Example 5
The invention discloses an embodiment of toothpaste for removing tooth stains and inhibiting dental plaque, which comprises the following preparation raw materials in percentage by weight: 2.5% of cordyceps militaris essence, 0.06% of O-cymene-5-alcohol, 4% of potassium nitrate, 0.8% of sodium phytate, 1% of zinc citrate, 0.8% of polyvinylpyrrolidone, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris fruiting body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruiting body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 90: 10; the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Example 6
According to the embodiment of the toothpaste for removing dental stain and inhibiting dental plaque, the toothpaste for removing dental stain and inhibiting dental plaque is different from the toothpaste for removing dental stain and inhibiting dental plaque in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the toothpaste for removing dental stain and inhibiting dental plaque is 5% by weight of the raw materials for preparing the toothpaste.
Example 7
According to the embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment is different from the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment accounts for 4 wt% of raw materials for preparing the toothpaste.
Example 8
According to the embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment is different from the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment accounts for 2% by weight of raw materials for preparing the toothpaste.
Example 9
According to the embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment is different from the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment accounts for 1% by weight of raw materials for preparing the toothpaste.
Example 10
According to the embodiment of the toothpaste for removing dental stain and inhibiting dental plaque, the toothpaste for removing dental stain and inhibiting dental plaque in the embodiment is different from the toothpaste for removing dental stain and inhibiting dental plaque in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the toothpaste for removing dental stain and inhibiting dental plaque in the embodiment accounts for 0.1% of the toothpaste raw materials for preparing the toothpaste.
Example 11
According to an embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the preparation raw materials of the toothpaste are different from those of the toothpaste of the embodiment 5 only in the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruit body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 99.9: 0.01.
example 12
According to an embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the preparation raw materials of the toothpaste are different from those of the toothpaste of the embodiment 5 only in the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruit body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 95: 5.
example 13
According to an embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the preparation raw materials of the toothpaste are different from those of the toothpaste of the embodiment 5 only in the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruit body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 92: 8.
example 14
According to an embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the preparation raw materials of the toothpaste are different from those of the toothpaste of the embodiment 5 only in the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruit body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 85: 15.
example 15
According to an embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the preparation raw materials of the toothpaste are different from those of the toothpaste of the embodiment 5 only in the weight ratio of cordyceps militaris extract to cordyceps militaris fruit body, and the weight ratio of the cordyceps militaris extract to the cordyceps militaris fruit body is as follows: cordyceps militaris extract: cordyceps militaris fruit body 80: 20.
comparative example 1
The invention relates to a comparative example of toothpaste for removing tooth stains and inhibiting dental plaque, which is different from the toothpaste prepared in example 5 in that the raw materials for preparing the toothpaste do not contain cordyceps militaris essence, O-cymene-5-ol, sodium phytate, zinc citrate and polyvinylpyrrolidone, namely the toothpaste comprises the following raw materials in percentage by weight: 4% of potassium nitrate, 50% of a humectant, 22% of an abrasive, 2% of a thickening agent, 2% of a foaming agent, 1% of a sweetening agent, 2% of a pH regulator, 1% of a perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 2
The preparation raw materials of the toothpaste of the comparative example are different from those of the toothpaste of the example 5 in that the preparation raw materials of the toothpaste of the comparative example do not contain O-cymene-5-alcohol, sodium phytate, zinc citrate and polyvinylpyrrolidone, namely the toothpaste of the comparative example comprises the following preparation raw materials in percentage by weight: 2.5% of cordyceps militaris essence, 4% of potassium nitrate, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 3
The invention relates to a comparative example of toothpaste for removing tooth stains and inhibiting dental plaque, which is different from the toothpaste prepared in example 5 in that the raw materials for preparing the toothpaste do not contain cordyceps militaris essence, sodium phytate, zinc citrate and polyvinylpyrrolidone, namely the toothpaste comprises the following raw materials in percentage by weight: 0.06% of O-cymene-5-alcohol, 4% of potassium nitrate, 50% of a humectant, 22% of an abrasive, 2% of a thickening agent, 2% of a foaming agent, 1% of a sweetener, 2% of a pH regulator, 1% of a perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 4
The invention relates to a comparative example of toothpaste for removing tooth stains and inhibiting dental plaque, which is different from the toothpaste prepared in example 5 in that the raw materials for preparing the toothpaste do not contain cordyceps militaris essence, O-cymene-5-ol, zinc citrate and polyvinylpyrrolidone, namely the toothpaste comprises the following raw materials in percentage by weight: 4% of potassium nitrate, 0.8% of sodium phytate, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 5
The invention relates to a comparative example of toothpaste for removing tooth stains and inhibiting dental plaque, which is different from the toothpaste prepared in example 5 in that the raw materials for preparing the toothpaste do not contain cordyceps militaris essence, O-cymene-5-ol, sodium phytate and polyvinylpyrrolidone, namely the toothpaste comprises the following raw materials in percentage by weight: 4% of potassium nitrate, 1% of zinc citrate, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 6
The invention relates to a comparative example of toothpaste for removing tooth stains and inhibiting dental plaque, which is different from the toothpaste prepared in example 5 in that the raw materials for preparing the toothpaste do not contain cordyceps militaris essence, O-cymene-5-ol, sodium phytate and zinc citrate, namely the toothpaste comprises the following raw materials in percentage by weight: 4% of potassium nitrate, 0.8% of polyvinylpyrrolidone, 50% of humectant, 22% of abrasive, 2% of thickener, 2% of foaming agent, 1% of sweetener, 2% of pH regulator, 1% of perfume and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 7
The invention relates to a comparative example of toothpaste for removing tooth stains and inhibiting dental plaque, which is different from the toothpaste prepared in example 5 in that the raw materials for preparing the toothpaste do not contain cordyceps militaris essence, O-cymene-5-ol, polyvinylpyrrolidone, potassium nitrate, sodium phytate and zinc citrate, namely the toothpaste comprises the following raw materials in percentage by weight: 50% of humectant, 22% of abrasive, 2% of thickening agent, 2% of foaming agent, 1% of sweetening agent, 2% of pH regulator, 1% of spice and the balance of deionized water;
wherein the humectant is a mixture of sorbitol and glycerol; the thickening agent is carbomer; the foaming agent is a mixture of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and sodium dodecyl sulfate; the abrasive is a mixture of precipitated silica and ultrafine silica, and the weight percentage of the ultrafine silica in the raw materials for preparing the tooth stain removal and plaque inhibition toothpaste is 4%; the sweetener is saccharin sodium; the spice is sweet orange oil; the pH regulator is anhydrous trisodium phosphate.
Comparative example 8
According to the embodiment of the toothpaste for removing dental stains and inhibiting dental plaque, the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment is different from the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment 5 only in content of cordyceps militaris essence, and the cordyceps militaris essence of the toothpaste for removing dental stains and inhibiting dental plaque in the embodiment accounts for 6% by weight of the raw materials for preparing the toothpaste.
Comparative example 9
The invention relates to a comparative example of toothpaste for removing dental stains and inhibiting dental plaque, which is prepared from the following raw materials in different weight ratios of cordyceps militaris extract and cordyceps militaris fruit body: cordyceps militaris extract: the ratio of cordyceps militaris fruit body is 100: 0.
Comparative example 10
The invention relates to a comparative example of toothpaste for removing dental stains and inhibiting dental plaque, which is prepared from the following raw materials in different weight ratios of cordyceps militaris extract and cordyceps militaris fruit body: cordyceps militaris extract: the ratio of cordyceps militaris fruit body is 75: 25.
Example 16
The toothpaste for removing tooth stains and inhibiting dental plaque in the examples 1-15 and the toothpaste in the comparative examples 1-10 are subjected to bacteriostasis tests on several common bacteria in the oral cavity.
The bacteriostasis test method comprises the following steps: the test was carried out by a third party agency according to the test method for resistance (inhibition) of Disinfection Specification 2.1.8.
Preparing the bacteriostatic tablets: preparing bacteriostatic agent raw paste sheets with the diameter of 5mm and the thickness of no more than 4mm in a clean sterile plate, and grouping every 4 sheets (blocks).
Preparation of negative pair photographs: taking a sterile dry filter paper sheet, and dripping sterile distilled water into each sheet for later use.
Inoculation of test bacteria by dipping with sterile cotton swab at 5 × 10 concentration5cfu/ml～5×106The cfu/ml test bacterial suspension is evenly smeared on the surface of a nutrient agar medium flat plate for 3 times, the flat plate should rotate 60 degrees every time the smearing is carried out for 1 time, finally, a cotton swab is smeared for a circle around the edge of the flat plate, the flat plate is covered, and the room temperature is kept for drying for 5 min.
Sticking bacteriostatic agent sample pieces: each test is stuck with 1 infectious bacterium plate, each plate is stuck with 4 test sample plates of the same test group, 1 negative pair photo, and 5 negative pair photos. A sample was taken with sterile forceps and placed on the surface of the plate. The distance between the centers of the various pieces is more than 25mm, and the distance between the centers of the various pieces and the periphery of the flat plate is more than 15 mm. After the adhesive tape is well stuck and placed,
the sample wafer is lightly pressed with sterile forceps to be tightly attached to the surface of the flat plate. The plate is covered, the plate is placed in an incubator at 37 ℃, and the result is observed after the plate is cultured for 16 to 18 hours. The direct measurement of the zone of inhibition was measured with a vernier caliper and recorded, and the test was repeated 3 times.
The strains tested at this time selected common oral pathogens: staphylococcus aureus, streptococcus mutans, and porphyromonas gingivalis.
And (3) bacteriostatic test evaluation standard: if the diameter of the bacteriostatic ring is larger than 7mm, the bacteriostatic ring is judged to have bacteriostatic action; if the diameter of the antibacterial ring is less than or equal to 7mm, the product is judged to have no antibacterial effect. The results of the bacteriostatic tests of the toothpastes in the examples 1 to 10 and the comparative examples 1 to 7 are shown in table 1, the results of the bacteriostatic tests of the toothpastes in the example 5 and the comparative examples 1 to 7 are shown in attached figures 1 to 3, and the results of the bacteriostatic tests of the toothpastes in the examples 5, 11 to 15 and the comparative examples 8 and 9 are shown in table 2.
TABLE 1 results of bacteriostatic tests on toothpastes described in examples 1 to 10 and comparative examples 1 to 7
As can be seen from Table 1, the antibacterial effect of the toothstain removing and plaque inhibiting toothpaste of examples 1-10 is better than that of the toothpaste of comparative examples 1-8, especially, the antibacterial effect of example 5 is better than that of the toothpaste of comparative examples 1-7 in the attached figures 1-3, the antibacterial effect of example 5 is better than that of the toothpaste without one or more of Cordyceps militaris essence, O-cymene-5-ol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone or with only one or more of Cordyceps militaris essence, O-cymene-5-ol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone, the cordyceps militaris essence, the O-cymene-5-alcohol, the potassium nitrate, the sodium phytate, the zinc citrate and the polyvinylpyrrolidone are compounded in a certain proportion range, so that the synergistic bactericidal and bacteriostatic effects can be achieved. From the antibacterial effect comparative examples of the embodiments 5-10 and the comparative example 8, it can be obtained that the antibacterial effect is increased along with the increase of the addition amount of the cordyceps militaris essence, but compared with the embodiment 6, the addition amount of the comparative example 8 is increased by 1%, but the antibacterial effect is not obviously increased.
TABLE 2 results of bacteriostatic tests on the toothpastes of examples 5, 11-15 and comparative examples 7, 8
As can be seen from table 2, under the condition of a certain content of the essence of cordyceps militaris, the antibacterial effect of the prepared toothpaste tends to increase and decrease with the increase of the content of the fruiting body of cordyceps militaris, and the weight ratio of the extract of cordyceps militaris to the fruiting body of cordyceps militaris is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: the best effect is achieved when the temperature is 8-15 ℃.
Example 17
Clinical tests for removing stains from the toothpaste for inhibiting dental plaque according to example 4 of the present invention and the toothpaste according to comparative example 7 were conducted, and the specific test protocol was as follows:
grading and scoring by Lobene color spot index, evaluating the size of the color spot part and the color spot degree by 0-3 grades,
as shown in table 3:
TABLE 3 Scoring level criteria
The tooth positions are checked to be the lip and the lingual surface of the mandibular anterior teeth and the labial surface of the maxillary anterior teeth. Each tooth surface is divided into two measuring areas: gum area and tooth area. The mean stain score for each subject was the size score mean and the degree score mean. The average number of area scores is the sum of the color spot size scores of each tooth surface divided by the total number of tooth surfaces, namely the color spot size score/the total number of tooth surfaces to be checked, and the average number of degree scores is as follows: stain level score/total number of teeth examined. The inspection of all color spots is completed by one inspector, the inspector does not know the type of the toothpaste used by the testee, the error of the inspector is measured before the inspection, the Kappa value of the inspector is 0.85, and the reliability is high.
The test group toothpaste was the toothpaste of example 4 and the control group toothpaste was the toothpaste of control 8, and the subjects were asked to brush their teeth twice a day for 2min and clinical examinations were performed at baseline, 4 weeks and 8 weeks.
The total number of the volunteer testers is 122, and the tests in 8 weeks are completed in 62 cases, 30 cases for men and 32 cases for women in the test group; the control groups 60, 31 men and 29 women all had an average age of 35 years. The results of Lobene stain index at baseline examination in volunteers are shown in Table 4, and the test showed no statistical difference between the two groups (P > 0.5).
Table 4 results of Lobene stain index at baseline examination of volunteer experimenters
| Inspection index | Toothpaste tube | Number of human subjects | Lobene stain index |
| Size of color spot | Example 4 | 62 | 1.87±0.32 |
| Degree of color mottle | Example 4 | 62 | 1.60±0.21 |
| Size of color spot | Comparative example 7 | 60 | 1.71±0.29 |
| Degree of color mottle | Comparative example 7 | 60 | 1.52±0.15 |
The results of the 4 th and 8 th week examinations of the volunteer subjects are shown in Table 5, and the statistical analysis shows that example 4 has a significant statistical difference (P < 0.5) compared to comparative example 7.
TABLE 5 examination results of volunteers at week 4 and Lobene stain index at week 8
As can be seen from tables 4 and 5, the use of the stain-removing plaque-inhibiting toothpaste described in example 4 is effective in treating the removal and inhibiting the formation of plaque, compared to comparative example 7, after 4 weeks and 8 weeks using the toothpastes described in example 4 and comparative example 7.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention is described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. A toothpaste for removing tooth stain and inhibiting dental plaque is characterized by comprising Cordyceps militaris essence, O-cymene-5-ol, potassium nitrate, sodium phytate, zinc citrate and polyvinylpyrrolidone; the cordyceps militaris essence is a mixture of cordyceps militaris extract and cordyceps militaris sporocarp; the toothpaste for removing tooth stains and inhibiting dental plaque comprises the following preparation raw materials in percentage by weight: 0.1-5% of cordyceps militaris essence, 0.01-0.1% of O-cymene-5-alcohol, 3-10% of potassium nitrate, 0.2-2% of sodium phytate, 0.25-2% of zinc citrate and 0.25-2% of polyvinylpyrrolidone; the weight ratio of the cordyceps militaris extract to the cordyceps militaris sporocarp is as follows: cordyceps militaris extract: and (3) cordyceps militaris fruit body of 85-92: 8-15.
2. The dental stain removal and inhibition toothpaste according to claim 1 wherein the dental stain removal and inhibition toothpaste comprises the following raw materials by weight percent: 0.5-3% of cordyceps militaris essence, 0.05-0.08% of O-cymene-5-alcohol, 3-5% of potassium nitrate, 0.2-1% of sodium phytate, 0.5-1.5% of zinc citrate and 0.25-1% of polyvinylpyrrolidone.
3. The stain removing and plaque inhibiting toothpaste according to claim 1 wherein the stain removing and plaque inhibiting toothpaste is prepared from ingredients further comprising a humectant, an abrasive, a thickener, and a foaming agent.
4. The toothpaste for removing dental stains and inhibiting dental plaque as claimed in claim 3, wherein the toothpaste for removing dental stains and inhibiting dental plaque is prepared from the following raw materials, by weight, 30 to 50% of the humectant, 16 to 40% of the abrasive, 0.5 to 3% of the thickener, and 1.8 to 3% of the foaming agent.
5. The tooth stain removal plaque inhibiting dentifrice of claim 3 wherein said foaming agent is a mixture of sodium lauryl sulfate and at least one of an amino acid surfactant and an amphoteric surfactant.
6. The tooth stain removal plaque inhibiting dentifrice of claim 3 wherein said foaming agent is a mixture of sodium lauryl sulfate and at least one of sodium lauroyl sarcosinate, sodium lauroyl methyltaurate and cocamidopropyl betaine.
7. The tooth stain removal plaque inhibiting dentifrice of claim 3 wherein said abrasive agent is at least one of precipitated silica, ultra fine silica, calcium hydrogen phosphate and calcium carbonate.
8. The toothpaste for removing dental stains and inhibiting dental plaque as claimed in claim 3, wherein the abrasive is a mixture of at least one of precipitated silica, calcium hydrogen phosphate and calcium carbonate and ultrafine silica, wherein the toothpaste for removing dental stains and inhibiting dental plaque is prepared from 2-6 wt% of ultrafine silica.
9. The tooth stain removal and plaque inhibition dentifrice of claim 3 wherein the thickening agent is at least one of sodium carboxymethylcellulose, carbomer and xanthan gum; the humectant is at least one of sorbitol, glycerol, polyethylene glycol and propylene glycol.
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| CN108324675B (en) * | 2018-04-04 | 2018-12-28 | 三椒口腔健康股份有限公司 | A kind of toothpaste and preparation method thereof containing lactobacillus paracasei |
| CN108670881A (en) * | 2018-08-16 | 2018-10-19 | 苏州清馨健康科技有限公司 | Whitening maintenance toothpaste |
| CN109568189A (en) * | 2018-12-27 | 2019-04-05 | 温州市森马网络技术有限公司 | One kind is antibacterial to remove stain nanometer toothpaste and preparation method thereof |
| WO2021067683A1 (en) * | 2019-10-02 | 2021-04-08 | Isp Investments Llc | Carbomer based tooth paste composition comprising crosslinked polyvinylpyrrolidone for building viscosity |
| CN110755309A (en) * | 2019-11-08 | 2020-02-07 | 苏州克劳丽化妆品有限公司 | Cordyceps militaris essence particles, cordyceps militaris toothpaste and preparation methods of cordyceps militaris essence particles and cordyceps militaris toothpaste |
| CN112315827B (en) * | 2020-09-25 | 2023-02-28 | 好维股份有限公司 | Oral care composition and application |
| CN114259424A (en) * | 2021-12-24 | 2022-04-01 | 福建爱洁丽日化有限公司 | Anhydrous antibacterial toothpaste containing peach carin and cymene and preparation method thereof |
| CN114795993B (en) * | 2022-02-25 | 2024-03-19 | 上海弗艾柏生物科技有限公司 | Antibacterial and antiseptic composition for pet oral cleaning product and application thereof |
| CN115025022B (en) * | 2022-07-13 | 2023-09-05 | 湖南互美电子商务有限公司 | Antibacterial toothpaste and preparation method thereof |
| CN115813799A (en) * | 2022-12-09 | 2023-03-21 | 云南白药集团健康产品有限公司 | Whitening and tooth-protecting composition and application thereof in oral care products |
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