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CN107279923A - ginseng composite fermentation nutrient powder and preparation method thereof - Google Patents

ginseng composite fermentation nutrient powder and preparation method thereof Download PDF

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Publication number
CN107279923A
CN107279923A CN201710559771.8A CN201710559771A CN107279923A CN 107279923 A CN107279923 A CN 107279923A CN 201710559771 A CN201710559771 A CN 201710559771A CN 107279923 A CN107279923 A CN 107279923A
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ginseng
powder
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fermented
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曲迪
孙印石
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Institute Special Animal and Plant Sciences CAAS
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L25/00Food consisting mainly of nutmeat or seeds; Preparation or treatment thereof
    • A23L25/30Mashed or comminuted products, e.g. pulp, pastes, meal, powders; Products made therefrom, e.g. blocks, flakes, snacks; Liquid or semi-liquid products
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/12Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/12Fermented milk preparations; Treatment using microorganisms or enzymes
    • A23C9/13Fermented milk preparations; Treatment using microorganisms or enzymes using additives
    • A23C9/1315Non-milk proteins or fats; Seeds, pulses, cereals or soja; Fatty acids, phospholipids, mono- or diglycerides or derivatives therefrom; Egg products
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    • A23CDAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING OR TREATMENT THEREOF
    • A23C9/00Milk preparations; Milk powder or milk powder preparations
    • A23C9/16Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L19/00Products from fruits or vegetables; Preparation or treatment thereof
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    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L7/00Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10Cereal-derived products
    • A23L7/104Fermentation of farinaceous cereal or cereal material; Addition of enzymes or microorganisms
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L7/00Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10Cereal-derived products
    • A23L7/198Dry unshaped finely divided cereal products, not provided for in groups A23L7/117 - A23L7/196 and A23L29/00, e.g. meal, flour, powder, dried cereal creams or extracts
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23PSHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00Shaping or working of foodstuffs characterised by the products
    • A23P10/30Encapsulation of particles, e.g. foodstuff additives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction

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Abstract

本发明涉及营养保健食品领域,具体而言,涉及一种人参复合发酵营养粉及其制备方法。以重量份计,所述发酵营养粉主要由以下原料组份制备得到:人参10~20份、薏苡仁15~20份、山药20~30份、大枣5~10份、枸杞5~10份、核桃20~30份以及黑芝麻25~35份。所述发酵营养粉的制备方法是将主要原料用水回流提取,经乳酸菌发酵后再经过喷雾干燥而得。该发酵营养粉由几种具有保健功效的原料复配而成,具有一定的保健功效,无毒副反应;利用微胶囊技术,制成人参复合发酵营养粉,可做代餐食品,热水冲服,方便快捷;能有效抗疲劳,使人具有饱腹感,缓解亚健康状态。The invention relates to the field of nutrition and health food, in particular to a ginseng compound fermented nutrition powder and a preparation method thereof. In parts by weight, the fermented nutritional powder is mainly prepared from the following raw material components: 10-20 parts of ginseng, 15-20 parts of coix seed, 20-30 parts of yam, 5-10 parts of jujube, and 5-10 parts of wolfberry , 20-30 parts of walnuts and 25-35 parts of black sesame. The preparation method of the fermented nutrient powder is obtained by reflux extracting main raw materials with water, fermenting by lactic acid bacteria and then spray drying. The fermented nutrient powder is compounded from several raw materials with health-care effects, has certain health-care effects, and has no toxic side effects; it is made of ginseng compound fermented nutrient powder by using microcapsule technology, which can be used as a meal replacement food and taken in hot water , convenient and fast; it can effectively resist fatigue, make people feel full, and relieve sub-health status.

Description

人参复合发酵营养粉及其制备方法Ginseng compound fermented nutrition powder and preparation method thereof

技术领域technical field

本发明涉及营养保健食品领域,具体而言,涉及一种人参复合发酵营养粉及其制备方法。The invention relates to the field of nutrition and health food, in particular to a ginseng compound fermented nutrition powder and a preparation method thereof.

背景技术Background technique

人参为五加科植物人参(Panax ginseng C.A.Mey)的干燥根,是传统名贵中药,始载于我国第一部本草专著《神农本草经》。其栽培者称为“园参”,野生者称为“山参”。人参具有大补元气、复脉固脱、补脾益肺、生津、安神之功能,用于体虚欲脱、肢冷脉微、脾虚食少、肺虚喘咳、津伤口渴、内热消渴、久病虚羸、惊悸失眠、阳痿宫冷、心力衰竭、心源性休克等的治疗。李时珍在《本草纲目》中也对人参极为推崇,认为它能治“男妇一切虚症”。几千年来,中草药中人参都被列为“上品”。人参常用于愈后恢复、调节荷尔蒙、降低血糖、增强体力、控制肝指数和肝功能保健等。Ginseng is the dried root of Panax ginseng C.A.Mey, a plant of Araliaceae. It is a traditional precious Chinese medicine, which was first recorded in my country's first herbal monograph "Shen Nong's Herbal Classic". Its cultivators are called "garden ginseng" and wild ones are called "mountain ginseng". Ginseng has the functions of invigorating vital energy, recovering pulses, nourishing the spleen and benefiting the lungs, promoting body fluid, and calming the nerves. Thirst, chronic illness and weakness, palpitations, insomnia, impotence, cold uterus, heart failure, cardiogenic shock, etc. Li Shizhen also highly praised ginseng in "Compendium of Materia Medica", thinking that it can cure "all deficiencies in men and women". For thousands of years, ginseng has been listed as "top grade" in Chinese herbal medicine. Ginseng is often used for post-healing recovery, hormone regulation, lowering blood sugar, enhancing physical strength, controlling liver index and liver function health care, etc.

目前市面上的人参复方制品有很多,但一方面由于配伍关系不科学而使得其保健功效不显著,另一方面现有的产品多偏重于药用,口感较差且食用不是很方便,不利于人参制品进一步的加工和推广。微胶囊技术是指通过一定的工艺手段将某些活性成分包裹成微小封闭颗粒的方法。微胶囊材料的最大特点是有效改变物料的存在状态,便于加工、储藏和运输;有效保护生物活性成分和敏感成分,延长其保质期;降低或者掩盖某些成分的不良味道,降低添加剂等的毒理作用等等。若能将微胶囊技术应用于人参制品的加工中,不仅可以提供健康、营养保健品的生产工艺和配方,获得良好的经济效益,还能长期保持人参的营养成分,改善其口感,并且能够更方便的进行食用,。There are many ginseng compound products on the market, but on the one hand, their health benefits are not significant due to unscientific compatibility, and on the other hand, most of the existing products are used for medicinal purposes, with poor taste and inconvenient consumption, which is not conducive to Further processing and promotion of ginseng products. Microcapsule technology refers to the method of encapsulating certain active ingredients into tiny closed particles through certain technological means. The biggest feature of microcapsule materials is to effectively change the existing state of materials, which is convenient for processing, storage and transportation; effectively protect biological active ingredients and sensitive ingredients, prolong their shelf life; reduce or cover up the bad taste of some ingredients, reduce the toxicity of additives, etc. function and so on. If the microencapsulation technology can be applied to the processing of ginseng products, it can not only provide the production technology and formula of health and nutritional health products, obtain good economic benefits, but also maintain the nutritional content of ginseng for a long time, improve its taste, and be more It is convenient to eat,.

有鉴于此,特提出本发明。In view of this, the present invention is proposed.

发明内容Contents of the invention

本发明的第一目的在于提供一种人参复合发酵营养组合物,所述的组合物具有保健效果好,无明显的毒副反应等优点。The first object of the present invention is to provide a ginseng compound fermentation nutritional composition, which has the advantages of good health care effect and no obvious toxic and side effects.

为了实现本发明的上述目的,特采用以下技术方案:In order to realize the above-mentioned purpose of the present invention, special adopt following technical scheme:

本发明涉及一种人参复合发酵营养粉,以重量份计,主要由以下原料组份制备得到:The invention relates to a ginseng compound fermented nutritional powder, which is mainly prepared from the following raw material components in parts by weight:

人参10~20份、薏苡仁15~20份、山药20~30份、大枣5~10份、枸杞5~10份、核桃20~30份以及黑芝麻25~35份。10-20 parts of ginseng, 15-20 parts of coix seed, 20-30 parts of yam, 5-10 parts of jujube, 5-10 parts of wolfberry, 20-30 parts of walnut and 25-35 parts of black sesame.

本发明由几种具有保健功效的原料复配而成,并经过发酵工艺制备处理,具有一定的保健功效,无毒副反应;利用微胶囊技术,制成人参复合发酵营养粉,可做代餐食品,热水冲服,方便快捷;能有效抗疲劳,使人具有饱腹感,缓解亚健康状态。The invention is compounded from several raw materials with health-care effects, and is prepared through a fermentation process, so it has certain health-care effects and no toxic side effects; it uses microcapsule technology to make ginseng compound fermented nutrition powder, which can be used as a meal replacement Food, hot water, convenient and quick; can effectively fight fatigue, make people feel full, and relieve sub-health status.

本发明的第二目的在于提供如上所述的人参复合发酵营养粉的制备方法,包括:The second object of the present invention is to provide the preparation method of the ginseng compound fermented nutrient powder as described above, comprising:

1).将人参、薏苡仁、山药、大枣、枸杞打碎混合,加水加热回流浸提,将得到的浸提液与奶粉混合后进行灭菌处理得到发酵原料;1). Crush and mix ginseng, coix seed, Chinese yam, jujube and medlar, add water, heat and reflux for extraction, mix the obtained extract with milk powder, and then sterilize to obtain fermentation raw materials;

2).将乳酸菌接种到所述发酵原料中进行发酵,将得到的发酵产物进行干燥制成粉末,向所述粉末中加入核桃、黑芝麻以及面粉即得。2). Inoculate lactic acid bacteria into the fermentation raw material for fermentation, dry the obtained fermentation product to make powder, add walnut, black sesame and flour to the powder.

与现有技术相比,本发明的有益效果为:Compared with prior art, the beneficial effect of the present invention is:

(1)保健效果好,所用原料具有一定得保健功效,无明显的毒副反应;(1) The health care effect is good, the raw materials used have a certain health care effect, and there is no obvious toxic and side effect;

(2)以微胶囊形式制剂,食用方便,效果好;(2) It is prepared in the form of microcapsules, which is convenient to eat and has good effect;

(3)可代餐服用,且能有效抗疲劳,缓解亚健康状态。(3) It can be taken as a meal replacement, and can effectively resist fatigue and relieve sub-health status.

具体实施方式detailed description

本发明一方面涉及一种人参复合发酵营养粉,以重量份计,主要由以下原料组份制备得到:One aspect of the present invention relates to a ginseng compound fermented nutrition powder, which is mainly prepared from the following raw material components in parts by weight:

人参10~20份、薏苡仁15~20份、山药20~30份、大枣5~10份、枸杞5~10份、核桃20~30份以及黑芝麻25~35份。10-20 parts of ginseng, 15-20 parts of coix seed, 20-30 parts of yam, 5-10 parts of jujube, 5-10 parts of wolfberry, 20-30 parts of walnut and 25-35 parts of black sesame.

优选的,如上所述的人参复合发酵营养粉,以重量份计,主要由以下原料组份制备得到:Preferably, the above-mentioned ginseng compound fermented nutrient powder is mainly prepared from the following raw material components in parts by weight:

人参13~17份、薏苡仁16~19份、山药23~27份、大枣6~9份、枸杞6~9份、核桃23~27份以及黑芝麻28~32份。13-17 parts of ginseng, 16-19 parts of coix seed, 23-27 parts of yam, 6-9 parts of jujube, 6-9 parts of wolfberry, 23-27 parts of walnut and 28-32 parts of black sesame.

优选的,如上所述的人参复合发酵营养粉,以重量份计,主要由以下原料组份制备得到:Preferably, the above-mentioned ginseng compound fermented nutrient powder is mainly prepared from the following raw material components in parts by weight:

人参14~16份、薏苡仁17~18份、山药24~26份、大枣7~8份、枸杞7~8份、核桃24~26份以及黑芝麻29~31份。14-16 parts of ginseng, 17-18 parts of coix seed, 24-26 parts of yam, 7-8 parts of jujube, 7-8 parts of wolfberry, 24-26 parts of walnut and 29-31 parts of black sesame.

人参为五加科多年生草本植物人参(Panax ginseng C.A.Mey.)的根,甘微苦,温。具有大补元气,复脉固脱,补脾益肺,生津止渴,安神益智的功效。主治:劳伤虚损、食少、倦怠、反胃吐食、大便滑泄、虚咳喘促、自汗暴脱、惊悸、健忘、眩晕头痛、阳痿、尿频、消渴、妇女崩漏、小儿慢惊及久虚不复,一切气血津液不足之症。Ginseng is the root of Panax ginseng C.A.Mey., a perennial herb of Araliaceae, sweet and slightly bitter, warm. It has the effects of invigorating vitality, recovering veins and solidifying, nourishing the spleen and lungs, promoting body fluid and quenching thirst, calming the nerves and improving intelligence. Indications: Weakness due to fatigue, lack of food, fatigue, nausea and vomiting, slippery stool, cough and shortness of breath, spontaneous sweating, palpitations, forgetfulness, dizziness and headache, impotence, frequent urination, thirst, women's uterine bleeding, children's chronic Surprised and long-term deficiency, all symptoms of insufficiency of qi, blood and body fluid.

薏苡仁为禾本科植物薏苡的种仁。甘;淡;微寒。治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。Coix seed is the seed kernel of the Gramineae plant Coix. sweet; light; slightly cold. Control diarrhea, arthralgia due to dampness, spasm of tendons, dysflexion and extension, edema, beriberi, lung impotence, lung abscess, intestinal abscess, stranguria, leucorrhea.

山药为薯蓣科植物山药的块茎。主治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。Chinese yam is the tuber of the yam plant of the Dioscoreaceae family. Indications for spleen deficiency diarrhea, chronic dysentery, consumptive cough, thirst, nocturnal emission, leukorrhea, frequent urination.

大枣为鼠李科植物枣的干燥成熟果实。主治胃虚食少,脾弱便溏,气血津液不足,营卫不和,心悸怔忡。妇人赃躁。Jujube is the dry ripe fruit of the rhamnaceae plant jujube. Indications for deficiency of the stomach, lack of food, weak spleen, loose stools, insufficiency of Qi, blood and body fluid, disharmony between camp and health, and palpitations. The woman is dirty.

枸杞为茄科植物枸杞或宁夏枸杞的成熟果实。主治肝肾阴亏,腰膝酸软,头晕,目眩,目昏多泪,虚劳咳嗽,消渴,遗精。Lycium barbarum is the mature fruit of Lycium barbarum or Ningxia Lycium barbarum of Solanaceae. Indications of liver and kidney yin deficiency, soreness of the waist and knees, dizziness, dizziness, blurred vision and tears, consumptive cough, thirst, and nocturnal emission.

核桃为胡桃科植物胡桃Juglans regia L.的干燥成熟种子。主治肾虚喘嗽,腰痛脚弱,阳痿,遗精,小便频数,石淋,大便燥结。Walnut is the dry mature seed of Juglans regia L., a plant of Juglandaceae. Indications for asthma and cough due to kidney deficiency, low back pain, weak feet, impotence, nocturnal emission, frequent urination, stone stranguria, dry stool.

黑芝麻为脂麻科植物脂麻Sesamum indicum L.的种子。主治肝肾不足,虚风眩晕,风痹、瘫痪,大便燥结,病后虚羸,须发早白,妇人乳少。Black sesame is the seed of Sesamum indicum L., a plant of Sesamaceae. Indications for deficiency of liver and kidney, dizziness due to wind deficiency, arthralgia due to wind, paralysis, dry stool, weakness after illness, premature graying of beard and hair, and lack of breast milk in women.

本发明通过将上述组份进行配伍,并经过发酵工艺制备处理,可以抗疲劳,并系统性地针对热性体征的患者,对亚健康及其相关慢性病进行有效治疗,从而达到养生保健的目的。The present invention can resist fatigue by combining the above-mentioned components and undergoing fermentation process preparation, and effectively treat sub-health and related chronic diseases systematically for patients with thermal signs, so as to achieve the purpose of health care.

在一种优选的实施方式中,本发明提供的人参复合发酵营养粉的原料组份还包括:In a preferred embodiment, the raw material components of the ginseng compound fermented nutritional powder provided by the present invention also include:

奶粉40~50重量份;或42~48重量份;或44~46重量份;40-50 parts by weight of milk powder; or 42-48 parts by weight; or 44-46 parts by weight;

优选所述奶粉为脱脂奶粉。Preferably, the milk powder is skimmed milk powder.

在一种优选的实施方式中,本发明提供的人参复合发酵营养粉的原料组份还包括:In a preferred embodiment, the raw material components of the ginseng compound fermented nutritional powder provided by the present invention also include:

面粉20~30重量份;或22~28重量份;或24~26重量份。20-30 parts by weight of flour; or 22-28 parts by weight; or 24-26 parts by weight.

本发明还涉及人参复合发酵营养粉的制备方法的制备方法,包括:The present invention also relates to a preparation method of a ginseng compound fermented nutrient powder, comprising:

1).将人参、薏苡仁、山药、大枣、枸杞打碎混合,加水加热回流浸提,将得到的浸提液与奶粉混合后进行灭菌处理得到发酵原料;1). Crush and mix ginseng, coix seed, Chinese yam, jujube and medlar, add water, heat and reflux for extraction, mix the obtained extract with milk powder, and then sterilize to obtain fermentation raw materials;

2).将乳酸菌接种到所述发酵原料中进行发酵,将得到的发酵产物进行干燥制成粉末,向所述粉末中加入核桃、黑芝麻以及面粉即得。2). Inoculate lactic acid bacteria into the fermentation raw material for fermentation, dry the obtained fermentation product to make powder, add walnut, black sesame and flour to the powder.

优选的,如上所述的制备方法,在步骤1)中,所述人参、薏苡仁、山药、大枣、枸杞的总质量与所述水的固液比为1:(8~12),更优选1:(9~11);更优选为1:10。Preferably, in the above-mentioned preparation method, in step 1), the solid-to-liquid ratio of the total mass of the ginseng, coix seed, yam, jujube, and wolfberry to the water is 1: (8-12), more Preferably 1:(9-11); more preferably 1:10.

优选的,如上所述的制备方法,在步骤1)中,所述加热回流浸提具体为:Preferably, in the preparation method as described above, in step 1), the heating and reflux extraction is specifically:

在55℃~65℃的条件下回流提取1.5h~2.5h,提取两次后合并浸提液;Under the condition of 55°C-65°C, reflux extraction for 1.5h-2.5h, after two extractions, combine the extracts;

更优选的,在步骤1)中,所述加热回流浸提具体为:More preferably, in step 1), the heating and reflux extraction is specifically:

在58℃~62℃的条件下回流提取1.8h~2.2h,提取两次后合并浸提液;Under the condition of 58°C-62°C, reflux extraction for 1.8h-2.2h, after two extractions, combine the extracts;

更优选的,在步骤1)中,所述加热回流浸提具体为:More preferably, in step 1), the heating and reflux extraction is specifically:

在59℃~61℃的条件下回流提取1.9h~2.1h,提取两次后合并浸提液。Under the condition of 59°C to 61°C, extract under reflux for 1.9h to 2.1h, extract twice and combine the extracts.

优选的,如上所述的制备方法,所述乳酸菌按3~5wt%的接种量接种到所述发酵原料中进行发酵,40℃~44℃发酵6h~10h;Preferably, in the above-mentioned preparation method, the lactic acid bacteria are inoculated into the fermentation raw material at an inoculum amount of 3-5wt% for fermentation, and fermented at 40°C-44°C for 6h-10h;

其中,在所述混合发酵剂中,所述乳酸菌的活菌数为1×108~10CFU/g;Wherein, in the mixed starter, the number of live bacteria of the lactic acid bacteria is 1×10 8 ~ 10 CFU/g;

更优选的,所述乳酸菌按4wt%的接种量接种到所述发酵原料中进行发酵,41℃~43℃发酵7h~9h;More preferably, the lactic acid bacteria are inoculated into the fermentation material at an inoculum amount of 4wt% for fermentation, and fermented at 41°C to 43°C for 7h to 9h;

其中,在所述混合发酵剂中,所述乳酸菌的活菌数为1×109CFU/g。Wherein, in the mixed starter, the viable count of the lactic acid bacteria is 1×10 9 CFU/g.

优选的,如上所述的制备方法,在步骤2)中,所述干燥为喷雾干燥;优选在进行所述喷雾干燥时,进风温度为180℃~200℃;更优选的,190℃。Preferably, in the above-mentioned preparation method, in step 2), the drying is spray drying; preferably, when the spray drying is carried out, the inlet air temperature is 180°C-200°C; more preferably, 190°C.

下面将结合实施例对本发明的实施方案进行详细描述,但是本领域技术人员将会理解,下列实施例仅用于说明本发明,而不应视为限制本发明的范围。实施例中未注明具体条件者,按照常规条件或制造商建议的条件进行。所用试剂或仪器未注明生产厂商者,均为可以通过市购买获得的常规产品。Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all conventional products that could be purchased from the market.

实施例1Example 1

本实施例提供了一种人参复合发酵营养粉微胶囊的加工方法,将人参10g、薏苡仁20g、山药20g、大枣5g、枸杞10g打碎混合,加纯净水,固液比为1:10,在65℃的条件下回流提取1.5h,提取两次,过滤弃固体,在滤后的溶液中加入脱脂奶粉40g制成混合液,121℃灭菌20min。将活化、驯化好的乳酸菌进行扩大培养制成发酵剂,按3wt%的接种量将发酵剂接种到混合液中进行发酵,44℃发酵6h,得到人参复合乳酸发酵液;在所述混合发酵剂中,所述乳酸菌的活菌数均1×109CFU/g。调整人参复合乳酸发酵液适当浓度,进行喷雾干燥,进风温度为180℃。向喷出来的人参复合发酵微胶囊中加入磨碎的核桃30g、黑芝麻25g以及面粉30g即为营养粉成品。This example provides a processing method of ginseng compound fermented nutrition powder microcapsules, crush and mix 10g ginseng, 20g coix seed, 20g Chinese yam, 5g jujube, and 10g wolfberry, add purified water, and the solid-liquid ratio is 1:10 , reflux extraction at 65°C for 1.5h, extract twice, filter to discard the solid, add 40g of skimmed milk powder to the filtered solution to make a mixed solution, and sterilize at 121°C for 20min. The activated and domesticated lactic acid bacteria are expanded and cultivated to make a starter, and the starter is inoculated into the mixed solution for fermentation according to an inoculation amount of 3 wt%, and fermented at 44° C. for 6 hours to obtain a ginseng compound lactic acid fermentation solution; in the mixed starter Among them, the number of live bacteria of the lactic acid bacteria was 1×10 9 CFU/g. Adjust the appropriate concentration of the ginseng compound lactic acid fermentation liquid, carry out spray drying, and the air inlet temperature is 180°C. Adding 30g of ground walnuts, 25g of black sesame seeds and 30g of flour into the ejected ginseng composite fermented microcapsules is the finished nutrition powder.

实施例2Example 2

本实施例提供了一种人参复合发酵营养粉微胶囊的加工方法,将人参20g、薏苡仁15g、山药30g、大枣10g、枸杞5g打碎混合,加纯净水,固液比为1:10,在55℃的条件下回流提取2.5h,提取两次,过滤弃固体,在滤后的溶液中加入脱脂奶粉50g制成混合液,121℃灭菌20min。将活化、驯化好的乳酸菌进行扩大培养制成发酵剂,按5wt%的接种量将发酵剂接种到混合液中进行发酵,40℃发酵10h,得到人参复合乳酸发酵液;在所述混合发酵剂中,所述乳酸菌的活菌数为1×109CFU/g。调整人参复合乳酸发酵液适当浓度,进行喷雾干燥,进风温度为200℃。向喷出来的人参复合发酵微胶囊中加入磨碎的核桃20g、黑芝麻35g以及面粉20g即为营养粉成品。This example provides a processing method of ginseng compound fermented nutrition powder microcapsules, crush and mix 20g ginseng, 15g coix seed, 30g Chinese yam, 10g jujube and 5g wolfberry, add purified water, and the solid-liquid ratio is 1:10 , reflux extraction at 55°C for 2.5h, extract twice, filter to discard the solid, add 50g of skimmed milk powder to the filtered solution to make a mixed solution, and sterilize at 121°C for 20min. The activated and domesticated lactic acid bacteria are expanded and cultivated to make a starter, and the starter is inoculated into the mixed solution for fermentation according to an inoculation amount of 5 wt%, and fermented at 40° C. for 10 hours to obtain a ginseng compound lactic acid fermentation solution; in the mixed starter , the viable count of the lactic acid bacteria was 1×10 9 CFU/g. Adjust the appropriate concentration of the ginseng compound lactic acid fermentation liquid, and carry out spray drying, and the air inlet temperature is 200°C. Add 20g of ground walnuts, 35g of black sesame seeds and 20g of flour into the sprayed ginseng composite fermented microcapsules to obtain the finished nutrition powder.

实施例3Example 3

本实施例提供了一种人参复合发酵营养粉微胶囊的加工方法,将人参15g、薏苡仁17g、山药25g、大枣7g、枸杞7g打碎混合,加纯净水,固液比为1:10,在60℃的条件下回流提取2h,提取两次,过滤弃固体,在滤后的溶液中加入脱脂奶粉45g制成混合液,121℃灭菌20min。将活化、驯化好的乳酸菌进行扩大培养制成发酵剂进行扩大培养制成发酵剂,按4wt%的接种量将发酵剂接种到混合液中进行发酵,42℃发酵8h,得到人参复合乳酸发酵液;在所述混合发酵剂中,所述乳酸菌的活菌数为1×109CFU/g。调整人参复合乳酸发酵液适当浓度,进行喷雾干燥,进风温度为190℃。向喷出来的人参复合发酵微胶囊中加入磨碎的核桃25g、黑芝麻30g以及面粉25g即为营养粉成品。This example provides a processing method of ginseng compound fermented nutritional powder microcapsules, crushing 15g ginseng, 17g coix seed, 25g yam, 7g jujube, and 7g medlar, and adding pure water, the solid-liquid ratio is 1:10 , reflux extraction at 60°C for 2h, extract twice, filter to discard the solid, add 45g of skimmed milk powder to the filtered solution to make a mixed solution, and sterilize at 121°C for 20min. The activated and domesticated lactic acid bacteria are expanded and cultivated to make a starter, and the starter is inoculated into the mixed solution according to the inoculation amount of 4wt% for fermentation, and fermented at 42°C for 8 hours to obtain a ginseng compound lactic acid fermentation solution ; In the mixed starter, the viable count of the lactic acid bacteria is 1×10 9 CFU/g. Adjust the appropriate concentration of ginseng compound lactic acid fermentation liquid, spray dry, and the air inlet temperature is 190°C. Add 25g of ground walnuts, 30g of black sesame seeds and 25g of flour into the sprayed ginseng composite fermented microcapsules to obtain the finished nutrition powder.

实验例1Experimental example 1

抗疲劳活性:强迫游泳实验建立疲劳模型。操作方法为:每天10:00AM~3:00PM,将小鼠单独放入盛有23-25℃,10cm高的水的塑料圆柱体(高25cm,直径10cm)中。每只小鼠被迫在水中6min,当小鼠终止挣扎,保持漂浮的状态(或仅有微小的动作以保持头部露出水面)则被认为是固定不动。总测试时间6min,前2min为适应期,后4min记录固定不动时间。每天给药后30min进行实验,连续15天,手动双盲法记录小鼠的固定不动时间和游泳时间。每只小鼠游泳结束后更换容器中的水。实验动物分组:将雄性ICR小鼠随机分组,每组20只。分别为生理盐水组(强迫游泳同时给予生理盐水组)、给样组(强迫游泳同时给实施例1~3制备得到的人参复合发酵营养粉微胶囊)、对照组。Anti-fatigue activity: Forced swimming test to model fatigue. The operation method is as follows: every day from 10:00 AM to 3:00 PM, put the mice individually into a plastic cylinder (25 cm high, 10 cm in diameter) filled with water at 23-25°C and 10 cm high. Each mouse was forced to stay in the water for 6 minutes, and when the mouse stopped struggling and kept floating (or only made small movements to keep the head out of the water), it was considered immobilized. The total test time is 6 minutes, the first 2 minutes is the adaptation period, and the immobilization time is recorded for the last 4 minutes. The experiment was carried out 30 minutes after administration every day, and the immobilization time and swimming time of the mice were recorded manually and double-blindly for 15 consecutive days. Change the water in the container after each mouse swims. Grouping of experimental animals: male ICR mice were randomly divided into groups, 20 in each group. They were normal saline group (forced swimming while giving normal saline), sample administration group (forced swimming and ginseng compound fermented nutrient powder microcapsules prepared in Examples 1-3), and control group.

对照组饲喂的人参复合发酵营养粉微胶囊制备方法同实施例3,区别仅在于没有经过发酵处理。The preparation method of the ginseng compound fermented nutrient powder microcapsule fed by the control group was the same as that in Example 3, the only difference being that it was not fermented.

给样组和对照组给药剂量为3g/kg/天,每天2次,持续15天,第16天进行强迫游泳实验,记录小鼠固定不动时间和游泳时间。结果表明,人参复合发酵营养粉微胶囊能够显著降低疲劳小鼠的固定不动时间,与对照组相比具有显著差异。因此,人参复合发酵营养粉微胶囊具有显著的缓解体力疲劳的功效。The dosage of the sample group and the control group was 3g/kg/day, twice a day, for 15 days, and the forced swimming test was performed on the 16th day, and the immobilization time and swimming time of the mice were recorded. The results showed that the ginseng compound fermented nutrient powder microcapsules could significantly reduce the immobility time of fatigued mice, which was significantly different from that of the control group. Therefore, the ginseng compound fermented nutrient powder microcapsules have a significant effect of alleviating physical fatigue.

表1小鼠强迫游泳实验固定不动时间统计表Table 1 Statistical table of immobility time in the forced swimming test of mice

实验例2Experimental example 2

本发明所述人参复合发酵营养粉微胶囊对热性体征亚健康的治疗效果,可通过下述临床病例观察加以证实:The therapeutic effect of the ginseng compound fermented nutrient powder microcapsules of the present invention on thermal signs and sub-health can be confirmed by following clinical case observations:

1、病人概况:选择符合亚健康疲劳诊断标准的患者100名,其中男性50例,女性50例,病程为3个月到6个月,年龄40-60岁,平均年龄51.4岁,体征均表现为寒性体征;全部病人均经西医一般常规体检排除常见疾病。1. Patient profile: Select 100 patients who meet the diagnostic criteria for sub-health fatigue, including 50 males and 50 females, the course of the disease is 3 to 6 months, the age is 40-60 years old, and the average age is 51.4 years old. It was a cold sign; all patients were ruled out of common diseases by routine physical examination of western medicine.

2、将上述100名患者随机分为5组,每组20人。其中对第1组患者不做任何处理,第2-4组患者使用实施例1-3制备得到的人参复合发酵营养粉微胶囊,第5组患者使用实验例1对照组制备的人参复合发酵营养粉微胶囊,服用量均为每天3次,每次1粒,持续服用2个月,取服药依从性大于90%的数据。2. The above 100 patients were randomly divided into 5 groups, 20 people in each group. Among them, no treatment is done to the patients in the first group, the patients in the 2-4 groups use the ginseng compound fermented nutrient powder microcapsules prepared in Example 1-3, and the patients in the 5th group use the ginseng compound fermented nutrient prepared by the control group in Experimental Example 1 The powder microcapsules are taken 3 times a day, 1 capsule each time, continuously taken for 2 months, and the data of taking medicine compliance is greater than 90%.

3、疗程结束后,统计疗效结果。疗效评定标准如实验例1所示,结果见表2。3. After the course of treatment is over, the curative effect results will be counted. The curative effect evaluation standard is shown in Experimental Example 1, and the results are shown in Table 2.

表2组方中药对寒性体征亚健康状态的治疗效果Table 2 Therapeutic Effects of Prescriptions of Traditional Chinese Medicine on Sub-Health Conditions with Cold Signs

尽管已用具体实施例来说明和描述了本发明,然而应意识到,在不背离本发明的精神和范围的情况下可以作出许多其它的更改和修改。因此,这意味着在所附权利要求中包括属于本发明范围内的所有这些变化和修改。While particular embodiments of the invention have been illustrated and described, it should be appreciated that various other changes and modifications can be made without departing from the spirit and scope of the invention. It is therefore intended to cover in the appended claims all such changes and modifications that are within the scope of this invention.

Claims (10)

1.一种人参复合发酵营养粉,其特征在于,以重量份计,主要由以下原料组份制备得到:1. A ginseng compound fermented nutrient powder is characterized in that, in parts by weight, it is mainly prepared from the following raw material components: 人参10~20份、薏苡仁15~20份、山药20~30份、大枣5~10份、枸杞5~10份、核桃20~30份以及黑芝麻25~35份。10-20 parts of ginseng, 15-20 parts of coix seed, 20-30 parts of yam, 5-10 parts of jujube, 5-10 parts of wolfberry, 20-30 parts of walnut and 25-35 parts of black sesame. 2.根据权利要求1所述的人参复合发酵营养粉,其特征在于,以重量份计,主要由以下原料组份制备得到:2. ginseng compound fermented nutritional powder according to claim 1, is characterized in that, in parts by weight, mainly prepared from the following raw material components: 人参13~17份、薏苡仁16~19份、山药23~27份、大枣6~9份、枸杞6~9份、核桃23~27份以及黑芝麻28~32份。13-17 parts of ginseng, 16-19 parts of coix seed, 23-27 parts of yam, 6-9 parts of jujube, 6-9 parts of wolfberry, 23-27 parts of walnut and 28-32 parts of black sesame. 3.根据权利要求1或2所述的人参复合发酵营养粉,其特征在于,所述原料组份还包括:3. The ginseng compound fermented nutrition powder according to claim 1 or 2, characterized in that, the raw material components also include: 奶粉40~50重量份;优选所述奶粉为脱脂奶粉。40-50 parts by weight of milk powder; preferably, the milk powder is skimmed milk powder. 4.根据权利要求1或2所述的人参复合发酵营养粉,其特征在于,所述原料组份还包括:4. The ginseng compound fermented nutrition powder according to claim 1 or 2, characterized in that, the raw material components also include: 面粉20~30重量份。20-30 parts by weight of flour. 5.权利要求1~4任一项所述的人参复合发酵营养粉的制备方法,其特征在于,包括:5. The preparation method of the ginseng compound fermented nutritional powder according to any one of claims 1 to 4, characterized in that it comprises: 1).将人参、薏苡仁、山药、大枣、枸杞打碎混合,加水加热回流浸提,将得到的浸提液与奶粉混合后进行灭菌处理得到发酵原料;1). Crush and mix ginseng, coix seed, Chinese yam, jujube and medlar, add water, heat and reflux for extraction, mix the obtained extract with milk powder, and then sterilize to obtain fermentation raw materials; 2).将乳酸菌接种到所述发酵原料中进行发酵,将得到的发酵产物进行干燥制成粉末,向所述粉末中加入核桃、黑芝麻以及面粉即得。2). Inoculate lactic acid bacteria into the fermentation raw material for fermentation, dry the obtained fermentation product to make powder, add walnut, black sesame and flour to the powder. 6.根据权利要求5所述的制备方法,其特征在于,在步骤1)中,所述人参、薏苡仁、山药、大枣、枸杞的总质量与所述水的固液比为1:(8~12)。6. The preparation method according to claim 5, characterized in that, in step 1), the solid-to-liquid ratio of the total mass of the ginseng, coix seed, Chinese yam, jujube and wolfberry to the water is 1:( 8~12). 7.根据权利要求6所述的制备方法,其特征在于,在步骤1)中,所述加热回流浸提具体为:7. The preparation method according to claim 6, characterized in that, in step 1), the reflux extraction is specifically: 在55℃~65℃的条件下回流提取1.5h~2.5h,提取两次后合并浸提液。Under the condition of 55°C to 65°C, reflux extraction for 1.5h to 2.5h, extract twice and combine the extracts. 8.根据权利要求5所述的制备方法,其特征在于,所述乳酸菌按3~5wt%的接种量接种到所述发酵原料中进行发酵,40℃~44℃发酵6h~10h;8. The preparation method according to claim 5, characterized in that, the lactic acid bacteria are inoculated into the fermentation raw material at an inoculation amount of 3-5wt% for fermentation, and fermented at 40°C-44°C for 6h-10h; 其中,在所述混合发酵剂中,所述乳酸菌的活菌数为1×108~10CFU/g。Wherein, in the mixed starter, the viable count of the lactic acid bacteria is 1×10 8 -10 CFU/g. 9.根据权利要求5所述的制备方法,其特征在于,在步骤2)中,所述干燥为喷雾干燥。9. The preparation method according to claim 5, characterized in that, in step 2), the drying is spray drying. 10.根据权利要求9所述的制备方法,其特征在于,在进行所述喷雾干燥时,进风温度为180℃~200℃。10 . The preparation method according to claim 9 , characterized in that, when the spray drying is carried out, the air inlet temperature is 180° C. to 200° C. 11 .
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