CN106954847A - Ferment probiotic composition with function of relaxing bowel, using and process preparation - Google Patents
Ferment probiotic composition with function of relaxing bowel, using and process preparation Download PDFInfo
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Abstract
The present invention disclose a kind of ferment probiotic composition with function of relaxing bowel, using and process preparation, composition includes vegetables and fruits plant enzyme powder, probiotics and dietary fiber；It gives full play to the mutually coordinated effect of vegetables and fruits plant enzyme powder, probiotics, dietary fiber, effectively alleviates and treatment constipation, Constipation recurrence；Also there is regulating intestinal canal colony balance, suppress the generation of harmful bacteria and toxin, promote the breeding and growth of beneficial bacterium；Regulation and recovery gastrointestinal function, strengthen gastrointestinal peristalsis；Promote excrement, the discharge of toxin in enteron aisle；It can also promote to digest simultaneously, supplement other nutritional ingredients such as nucleotides, organic acid for human body, promote the absorption of vitamin and minerals, enhance metabolism, the effects such as improving physical function.
Description
Technical field
The present invention relates to field of functional food technology, a kind of ferment probiotics with function of relaxing bowel is referred in particular to
Composition, using and process preparation.
Background technology
With the influence of the change of people's dietary structure, the quickening of rhythm of life, society and mental element, China's constipation
The incidence of disease is in rising trend, and according to the difference of definition, the incidence of disease of constipation is from 3.4% to 27.2%, and part constipation is serious
Person has had influence on quality of life, or even brings the diseases such as cancer.But constipation patient is generally constipation and worried, doctor can be seldom gone
Institute goes to a doctor, and attention degree is relatively low.
Omnibus survey research display, constipation shows obvious ascendant trend with the increase at age, and China is old
Total amount expansion, the developing state of increment speed-raising is presented in population size, with the arrival in aging population epoch, China constipation crowd
More expand.The problem of actively resolving constipation, can not only make it that the elderly, from the hardship of constipation, increases the life matter of the elderly
Amount, moreover it is possible to reduce the generation of constipation relevant disease is significant.
The teiology and Pathological Physiology of constipation are still unknown, and it is a kind of common complicated symptom of clinic, mainly
Refer to that defecation frequency is reduced, feces volume is reduced, excrement is dry and hard, defecation is hard, defecation not only sense, there is no satisfied happy sense after defecation
Etc..Constipation patient is generally also with symptoms such as insomnia, dreaminess, agitation, depression and anxiety.
From the point of view of the enteron aisle structure of human body, there are many bending and fold, second section colon and rectum inside our large intestine
It is the place for being easiest to hoard residue stool, while the change of habits and customs make it that the functions of expelling toxin of body declines, external environment condition
Change again cause more harmful substances enter in vivo formed toxin.The accumulation of intestines poison can form constipation, and constipation meeting
More intestines poison are produced, intestines poison can damage neuron, cause nervous centralis to be damaged, each organ immunity degradation of body forms sub-
Health.The toxin of stool still results in the arch-criminal of cancer, such as intestinal cancer, stomach cancer, cancer of the esophagus, liver cancer, breast cancer.Stool can make
Obtain enteron aisle to narrow, constipation is aggravated, and is long thinked little of, will be caused intestinal cancer, intestinal cancer is occupied first of 21 century cancer.
At present, general life treatment, drug therapy, biofeedback training are had according to its different therapeutic scheme of the cause of disease of constipation
And operative treatment.General life treatment be by adjusting life style, adjust mentality and appropriate motion gradually to recover defecation suitable
Smooth state, can fundamentally mitigation capability constipation.Therapeutic scheme is divided into external preparation and oral preparations, and enema is just
It is a kind of conventional external application purgatives, symptom after short-term relief symptom, deactivation can be played a part of and still have or even aggravate, taken stopgap measures
Do not effect a permanent cure.Oral preparations are generally by the permeability for changing enteron aisle or use some irritating plant cathartics, such as rheum officinale,
Folium sennae etc., reaches the purpose of defecation, but has the side effect for capturing catharsis more, the problems such as easily causing smooth amyotrophia, aggravates
Constipation.For serious organic constipation patient more than biofeedback training or operative treatment, such as serious obstinate Colonic transit work(
Can obstruction type constipation patient.
The narrow definition of ferment is enzyme, and it is indispensable with cytoactive that enzyme is that human body sustains life, and it is also cell weight
The constituent wanted.The number of internal ferment activity decides the health status of people, " ferment how many, life is with regard to how many ".
In fact, ferment as a kind of functional food in Japan and China Taiwan fashionable decades, it is with fresh
Vegetable and fruit etc. is raw material, and the fermentation through microorganism generates substantial amounts of enzyme, amino acid, trace element, two second generations of bacterium
Thank to the multiple nutritional components such as thing, can strengthen human body digests and assimilates function, build up resistance etc..
Probiotics is the class active microorganism beneficial to host, is colonized in human body intestinal canal, in reproductive system, can be produced really
Health efficacy is cut so as to the active beneficial microorganism general name for improving host's microecological balance, playing beneficial effect.Microorganism is deposited
It is multiple positions such as skin, oral cavity, nose, enteron aisle, the genitals of our human bodies, participates in multinomial physiological activity, such as nutrients
The digestion of matter and absorption, generation vitamin, strengthen immunity etc., probiotics is healthy closely bound up with ours.Enteron aisle
Tiny ecosystem is a beneficial bacterium and the Tiny ecosystem of harmful bacteria dynamic equilibrium, when harmful bacteria is dominant, can cause constipation, diarrhoea,
The malaise symptoms such as stomachache, abdominal distension, and be conducive to the probiotics of intestinal health effectively to alleviate the symptom of upset,gastro-intestinal.But bacterial strain
Difference, its stability and functional aberrancy are larger, the function and vigor of probiotics should the bacterial strain based on specific bacterial strain number carry out
Research.
Increasing evidence is shown, can be obviously improved or treat constipation or the related disease of constipation by enteric microorganism
Shape.Microorganism is changed in the enteron aisle of constipation patient, and the beneficial bacterium such as lactic acid bacteria, Bifidobacterium is reduced, and pseudomonas aeruginosa,
The pathogenic bacteria such as campylobacter jejuni are increased, and the metabolism environment of enteron aisle changes, and have influence on Instestinal motility and secreting function etc..Volume
The suitable probiotics preparation of outer supplement can recover environment, the generation of probiotics in the gut flora balance of constipation patient, regulation enteric cavity
PH in chamber can also be reduced by thanking to thing, and change the sensitiveness and intestines peristalsis ability of enteron aisle, thus significantly improve or treat it is chronic just
Secret and its related symptoms.
At present, also there are some patents of invention on ferment in China, there is that fermentation period is short, and raw material type is less, nutrition
Not enough enrich, it is difficult to the problems such as extracting vegetables and fruits elite completely.Or will jointly be sent out after the raw materials such as tens kinds of vegetables and fruits directly mixing
Ferment, because raw material type is more, parameter is difficult to control to, it is more difficult to realize scale quality stability.China is on the special of probiotics
Benefit is for the solid beverage in terms of regulating intestinal canal flora or modulation milk powder.Patent of invention on ferment plus probiotics also refers to more
Ferment product is made with probiotics fermention, probiotics can be removed in the sterilization process of product so that there was only ferment in finished product
Function and the effect of probiotics can not be played.
Such as CN 106173613 is the ferment health products using probiotics fermention fruits and vegetables or cereal or integration of drinking and medicinal herbs, has been fermented
It is degerming by membrane filtration after, obtain enzyme liquid.Products obtained therefrom only retains the active component of ferment, not active probiotic
Effect.
Composite plant ferment containing profitable probliotics described in CN 103876155 is to utilize the bacillus of three saccharomycete one
The raw material such as fermented cereal, vegetables and fruits, medicine-food two-purpose in four stages, obtains ferment fermentation liquid product, without active probiotic into
Divide, only the active component of the metabolin of bacterium and ferment.
Described in CN 106174179 with effect of relaxing bowel enzyme composition be with sterilizing after Chinese medical extract and
Enzyme stoste mixed liquor, is inoculated with spray drying after probiotics fermention and obtains, without the composition of active probiotic.
Plant enzyme probiotic powder described in CN 104489669 is that enzyme liquid first is made with microbial fermentation, spray-dried
Obtain zymogen powder, then be well mixed with other auxiliary materials such as probiotic powder obtained.The patent is similar to this patent, but the patent exists
Through high temperature spray-drying technique when preparing ferment, the vigor of the main functional component enzyme of ferment can be destroyed, is by all originals in addition
Expect the fermentation that is mixed, zymotechnique is difficult to standardization control, it is difficult to realize big production.Probiotics described in the patent is also still
The bacterial strain of the bacterial strain number of probiotics used, even same name is not pointed out, if bacterial strain difference, the function of the bacterial strain is stable
The parameters such as property, survival rate are also not quite similar.
Ferment spray drying that CN 106173773 is obtained with probiotics fermention or it is lyophilized obtain vegetables and fruits plant enzyme powder, then by benefit
Raw bacterium adds vacuum freeze drying after protective agent culture and obtains bacterium powder, adds mango powder, inulin, resistant dextrin, FOS system
.The patent is similar to this patent, but ferment powder used is only made with 5 kinds of fruits and vegetables, not yet elaborates the preparation process of ferment,
Selected raw material of the invention is more, and nutrition is more rich more balanced.In addition, the patent does not also do careful description and requirement to probiotics.
Generally speaking, the therapeutic scheme of relief of constipation is excessively stimulated again, and curative effect is fast but side effect is big, symptom after drug withdrawal
It is even worse.Patents and mostly Chinese herbal compounds, Chinese prescription composition are then excessively complicated, and therapeutic effect relatively slow, mouthfeel is not
It is good etc., and be difficult on the scheme of ferment probiotics while retaining both active components.Therefore a kind of healthy food is needed badly
The problem of product prescription is to solve constipation.
The content of the invention
In view of this, in view of the existing deficiencies of the prior art, its main purpose is to provide a kind of logical with ease constipation the present invention
Just the ferment probiotic composition of function, using and process preparation, it had both retained enzyme activity composition, and security is good, stability
Good, energy regulating intestinal canal flora promotes digestion, enhancing physical function etc..
To achieve the above object, the present invention is using following technical scheme：
A kind of ferment probiotic composition with function of relaxing bowel, include vegetables and fruits plant enzyme powder, probiotics and
Dietary fiber.
The vegetables and fruits plant enzyme powder is dried by 60 kinds of natural vegetables and fruits cereal and symbiosis probiotics after 540 days viable bacteria fermentations
Grind and obtain.
The probiotics is selected from bifidobacterium longum, animal bifidobacteria, Lactobacillus helveticus, Lactobacillus rhamnosus, acidophilus breast
One or more in bacillus, Lactobacillus plantarum, Lactobacillus casei and Bu Ladi yeast.
The dietary fiber is selected from water-soluble dietary fiber inulin, polydextrose, FOS, galactooligosaccharide, resistance
One or more in dextrin, konjaku flour；Or Water insoluble dietary fiber common oats fibre, Semen Tritici aestivi fiber, zein fiber, soybean are fine
One or more in the luxuriant isapgol husk of dimension, pea fibre, circle；Or the group of water-soluble dietary fiber and Water insoluble dietary fiber
Close.
The mass ratio of the vegetables and fruits plant enzyme powder, probiotics and dietary fiber is (2~60)：(0~2)：(10~80).
It is preferred that, the preparation process of the vegetables and fruits plant enzyme powder is：Selected fresh mature, non-rot fruits and vegetables, paddy
Thing is cleaned, section, osmotic pressure extractive fermentation, lactic acid deep-fermentation, acetic acid bacteria storage fermentation, afterripening fermentation, concentration, freezing
Dry, grind and obtain；
Described fruits and vegetables include：Banana, tomato, apple, Kiwi berry, pachyrhizus, pineapple, grape, spinach, cabbage, asparagus,
It is strawberry, lemon, orange, eggplant, wax gourd, pakchoi, guava, balsam pear, corn, lettuce, Sweet Potato Leaf, carambola, three-coloured amaranth, red sweet
Sugarcane, sponge gourd, folium artemisiae argyi, wild cabbage, water-rich areas, grape fruit, crowndaisy chrysanthemum, watermelon, plum, asparagus, broccoli, cabbage mustard, passion fruit, cocoa
Coconut, cumquat, leaf mustard, water spinach, wheat seedling, muskmelon, black fungus, cauliflower, green pepper, carrot, pumpkin, potato, plum,
Wax-apple, cucumber, mushroom, cherry, blue or green river dish, taro, radish；
Described cereal includes：Black soya bean, soya bean, brown rice, mung bean.
The symbiosis probiotics includes saccharomycete, bacillus, lactic acid bacteria, acetic acid bacteria；
540 days described viable bacteria fermentations include four-stage, 180 days extractive fermentation phases, 210 days submerged fermentation phases, storage
90 days fermentation phases, 60 days maturity periods；
The equal single fermentation of described vegetables and fruits plant material is formed after the completion of 540 days according still further to certain ratio chelating；
The moisture requirement of described vegetables and fruits plant enzyme powder is less than 5%.
It is preferred that, the probiotics is Lactobacillus helveticus Rosell-0052, Lactobacillus plantarum Rosell-1012, long bifid
Bacillus Rosell-0175, animal bifidobacteria LAFTI B94.
It is preferred that, the viable bacteria concentration of the probiotics is 1010Cfu/g~5 × 1011cfu/g。
It is preferred that, each bacterial strain percentage is Lactobacillus helveticus Rosell-0052 in the probiotics：Lactobacillus plantarum
Rosell-1012：Bifidobacterium longum Rosell-0175：Animal bifidobacteria LAFTI B94=(10%~60%)：(8%~
32%)：(2%~10%)：(30%~80%).
It is preferred that, the probiotics viable bacteria concentration in the composition is 104Cfu/g~1012Cfu/g, preferably 106cfu/
G~1011Cfu/g, preferred 108Cfu/g~1010cfu/g。
It is preferred that, the composition controls temperature at 18 DEG C~22 DEG C in preparation process, and humidity is 25%~35%.
It is preferred that, the dietary fiber is inulin, resistant dextrin.
It is preferred that, the mass ratio of the vegetables and fruits plant enzyme powder, probiotics and dietary fiber is (25~40)：(0.5~
1.5)：(40~70).
A kind of application of the ferment probiotic composition with function of relaxing bowel, the foregoing ferment with function of relaxing bowel
Application of the plain probiotic composition in the health products for preparing defaecation, alleviating or treating purgative function.
A kind of process preparation of the ferment probiotic composition with function of relaxing bowel, including Juice powder/slurry, sugar alcohol
Class material, filler, flavouring and the foregoing ferment probiotic composition with function of relaxing bowel.
It is preferred that, the shared mass fraction of the ferment probiotic composition with function of relaxing bowel for 10%~
60%.
It is preferred that, the Juice powder/slurry includes apple juice powder/slurry, grape juice powder/slurry, pineapple juice powder/slurry, lemon juice
Powder/slurry, strawberry juice powder/slurry, orange juice powder/slurry, orange juice powder/slurry, grapefruit juice powder/slurry, mango juice powder/slurry, blueberry juice powder/
Slurry, Cranberry Juice Cocktail powder/slurry, cherry juice powder/slurry, Lychee juice powder/slurry, bananas juice powder/slurry, coconut milk powder/slurry, Cantaloupe juice powder/
Slurry, peach juice powder/slurry, kiwi-fruit juice powder/slurry, pear juice powder/slurry, juice of my pomegranate powder/slurry etc., jujube juice powder/slurry, oat juice powder/
One or more in slurry；
The glycitols material is in xylitol, antierythrite, D-sorbite, mannitol, maltitol, lactitol
One or more；
One or more of the filler in maltodextrin, starch, microcrystalline cellulose, magnesium stearate；
The flavouring includes the one or more in sweetener, acid and essence；
The sweetener is selected from stevioside, Sucralose, Aspartame, acesulfame potassium, mogroside；Honey, high fructose corn
One or more in slurry, honey, glucose or white granulated sugar；
One or more of the acid in citric acid, malic acid, lactic acid；
The essence is selected from the essence of corresponding fruit powder.
It is preferred that, the process preparation is solid powder, granule, capsule, oral liquid or tablet.
The present invention has clear advantage and beneficial effect compared with prior art, specifically, by above-mentioned technical proposal
Understand：
Submerged fermentation in 540 days, depth extraction vegetables and fruits plant essence, and be fully retained the active component of ferment and nutrition into
Point, effectively exclude stool and intestines poison；Selected high stability, high-activity probiotics bacterial strain, effective regulating intestinal canal colony balance improve
Various enteron aisle malaise symptoms, and the repetition generation of energy Constipation；Inulin and resistant dextrin be both high-quality dietary fiber and
Good prebiotics, can not only strengthen the wriggling ability of stomach, recover intestinal health, promote defecation, and especially some are practised
Inertia constipation, intractable constipation has preferable improvement, can also promote the propagation of intestinal beneficial bacterium, suppresses pathogenic bacteria
Deng.The present invention significantly, treats both principal and secondary aspect of disease, had no toxic side effect for constipation symptom therapeutic effect caused by a variety of causes, safe and reliable.
Embodiment
Present invention is disclosed a kind of ferment probiotic composition with function of relaxing bowel, include vegetables and fruits plant enzyme
Powder, probiotics and dietary fiber；The vegetables and fruits plant enzyme powder is by 60 kinds of natural vegetables and fruits cereal and symbiosis probiotics through work in 540 days
Bacterium fermentation after drying and grinding and obtain；The probiotics is selected from bifidobacterium longum, animal bifidobacteria, Lactobacillus helveticus, rhamnose
One or more in lactobacillus, lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei and Bu Ladi yeast；The meals are fine
Tie up one kind in water-soluble dietary fiber inulin, polydextrose, FOS, galactooligosaccharide, resistant dextrin, konjaku flour
Or it is a variety of；Or the luxuriant car of Water insoluble dietary fiber common oats fibre, Semen Tritici aestivi fiber, zein fiber, soybean fiber, pea fibre, circle
One or more in preceding sub- shell；Or the combination of water-soluble dietary fiber and Water insoluble dietary fiber.The vegetables and fruits plant ferment
The mass ratio of plain powder, probiotics and dietary fiber is (2~60)：(0~2)：(10~80).
The preparation process of the vegetables and fruits plant enzyme powder is：Selected fresh mature, non-rot fruits and vegetables, cereal are through clear
Wash, cut into slices, osmotic pressure extractive fermentation, lactic acid deep-fermentation, acetic acid bacteria storage fermentation, afterripening fermentation, concentration, freeze-drying,
Grind and obtain；Described fruits and vegetables include：Banana, tomato, apple, Kiwi berry, pachyrhizus, pineapple, grape, spinach, cabbage, reed
It is bamboo shoot, strawberry, lemon, orange, eggplant, wax gourd, pakchoi, guava, balsam pear, corn, lettuce, Sweet Potato Leaf, carambola, three-coloured amaranth, red
Sugarcane, sponge gourd, folium artemisiae argyi, wild cabbage, water-rich areas, grape fruit, crowndaisy chrysanthemum, watermelon, plum, asparagus, broccoli, cabbage mustard, passion fruit, can
Can coconut, cumquat, leaf mustard, water spinach, wheat seedling, muskmelon, black fungus, cauliflower, green pepper, carrot, pumpkin, potato, plum
Son, wax-apple, cucumber, mushroom, cherry, blue or green river dish, taro, radish；Described cereal includes：Black soya bean, soya bean, brown rice, mung bean；Institute
Stating symbiosis probiotics includes saccharomycete, bacillus, lactic acid bacteria, acetic acid bacteria；540 days described viable bacteria fermentations include four ranks
Section, 180 days extractive fermentation phases, 210 days submerged fermentation phases, 90 days fermentation phases of storage, 60 days maturity periods；Described vegetables and fruits plant is former
Equal single fermentation is expected after the completion of 540 days, is formed according still further to certain ratio chelating；The moisture of described vegetables and fruits plant enzyme powder contains
Amount requires to be less than 5%.
The probiotics is Lactobacillus helveticus Rosell-0052, Lactobacillus plantarum Rosell-1012, bifidobacterium longum
Rosell-0175, animal bifidobacteria LAFTI B94.By stomach juice-resistant and bile survival experiment, adhesion experiment, antibacterial reality
Test, the external or authenticated high activity bacterial strain of in vivo studies.By the mutual synergy of this four plants of bacterium, on the one hand it can adjust
The harmful bacterias such as gut flora balance, reduction pseudomonas aeruginosa, the campylobacter jejuni related to constipation is suppressed, and promote lactic acid
The propagation of the intestinal beneficial bacteriums such as bacillus, Bifidobacterium.Improving the uncomfortable aspect of enteron aisle has obvious effect；On the one hand, it can pierce
Swash the immunologic function of human body, prevent the growth of above-mentioned pathogenic bacteria；A variety of important bioactivators, such as short chain fat can also be produced
Fat acid, can stimulate the power of ileum and colon, strengthen intestines peristalsis power.The viable bacteria concentration of the probiotics is 1010Cfu/g~5
×1011cfu/g.Each bacterial strain percentage is Lactobacillus helveticus Rosell-0052 in the probiotics：Lactobacillus plantarum
Rosell-1012：Bifidobacterium longum Rosell-0175：Animal bifidobacteria LAFTI B94=(10%~60%)：(8%~
32%)：(2%~10%)：(30%~80%).Probiotics viable bacteria concentration in the composition is 104Cfu/g~
1012Cfu/g, preferably 106Cfu/g~1011Cfu/g, preferred 108Cfu/g~1010cfu/g.It is prepared by the composition
During control temperature at 18 DEG C~22 DEG C, humidity is 25%~35%.The dietary fiber is inulin, vegetable described in resistant dextrin
The mass ratio of fruit plant enzyme powder, probiotics and dietary fiber is (25~40)：(0.5~1.5)：(40~70).
It is foregoing that there is profit present invention further teaches a kind of application of the ferment probiotic composition with function of relaxing bowel
Application of the ferment probiotic composition of intestines bowel relaxing functions in the health products for preparing defaecation, alleviating or treating purgative function.
The present invention also disclosed a kind of process preparation of the ferment probiotic composition with function of relaxing bowel, including fruit
Vegetable juice powder/slurry, glycitols material, filler, flavouring and the foregoing ferment probiotic composition with function of relaxing bowel.
The shared mass fraction of the ferment probiotic composition with function of relaxing bowel is 10%~60%.The Juice
Powder/slurry includes apple juice powder/slurry, grape juice powder/slurry, pineapple juice powder/slurry, lemon juice powder/slurry, strawberry juice powder/slurry, orange juice
Powder/slurry, orange juice powder/slurry, grapefruit juice powder/slurry, mango juice powder/slurry, blueberry juice powder/slurry, Cranberry Juice Cocktail powder/slurry, cherry juice powder/
Slurry, Lychee juice powder/slurry, bananas juice powder/slurry, coconut milk powder/slurry, Cantaloupe juice powder/slurry, peach juice powder/slurry, kiwi-fruit juice
One or more in powder/slurry, pear juice powder/slurry, juice of my pomegranate powder/slurry etc., jujube juice powder/slurry, oat juice powder/slurry；The sugar alcohol
One or more of the class material in xylitol, antierythrite, D-sorbite, mannitol, maltitol, lactitol；Institute
State one or more of the filler in maltodextrin, starch, microcrystalline cellulose, magnesium stearate；The flavouring includes sweet
One or more in taste agent, acid and essence；The sweetener is selected from stevioside, Sucralose, Aspartame, An Sai
Honey, mogroside；One or more in honey, fructose syrup, honey, glucose or white granulated sugar；The acid is selected from
One or more in citric acid, malic acid, lactic acid；The essence is selected from the essence of corresponding fruit powder.The process preparation is
Solid powder, granule, capsule, oral liquid or tablet.
Do further detailed to technical characteristic, implementation and the beneficial effect of the present invention with reference to specific implementation case
Describe in detail bright, embodiments described below is only a part of embodiment of the present invention, and not all embodiment.In following embodiments
The material unless otherwise noted, is common commercially available product, can all bought in market with reagent.
Wherein, vegetables and fruits plant enzyme powder is purchased from Taiwan big fellow group；
It is Lactobacillus helveticus Rosell-0052, Lactobacillus plantarum Rosell-1012, bifidobacterium longum Rosell-0175, dynamic
Thing Bifidobacterium LAFTI B94 are purchased from Raman group；
Embodiment 1：
A kind of ferment probiotics solid beverage with function of relaxing bowel, is made up of the raw material of following parts by weight：
The ferment probiotics solid beverage with function of relaxing bowel, including following preparation process：By vegetables and fruits plant
Fraction addition is abundant in proportion mixes for ferment powder, inulin, resistant dextrin, lactitol, Cranberry Juice Cocktail powder, then by Sucralose, lemon
The method that lemon acid, probiotic powder are mixed according to gradient is well mixed, and the material mixed is dispensed with powder packing machine, packaging
The product often wrapped into 5g, often bag ferment probiotics solid beverage dispatch from the factory viable count more than 1 × 1010CFU/ bags.It is required that production and processing
Shi Wendu is 18 DEG C~22 DEG C, and humidity is 25%~35%.
Eating method：It is dissolved in 200mL warm water to take, is please eaten as early as possible after opening.
Embodiment 2：
A kind of ferment probiotics solid beverage with function of relaxing bowel, is made up of the raw material of following parts by weight：
The ferment probiotics solid beverage with function of relaxing bowel, including following preparation process：By vegetables and fruits plant
Fraction addition is abundant in proportion mixes for ferment powder, inulin, resistant dextrin, lactitol, maltodextrin, strawberry juice powder, then by trichlorine
The method that sucrose, citric acid, probiotic powder are mixed according to gradient is well mixed, and the material mixed is divided with powder packing machine
Dress, is packaged into the product that 10g is often wrapped, and often bag ferment probiotics solid beverage dispatches from the factory viable count more than 6 × 109CFU/ bags.It is required that
Temperature is 18 DEG C~22 DEG C during production and processing, and humidity is 25%~35%.
Eating method：It is dissolved in 200mL warm water and takes, is please eaten as early as possible after opening.
Embodiment 3：
A kind of ferment probiotics solid beverage with function of relaxing bowel, is made up of the raw material of following parts by weight：
The ferment probiotics solid beverage with function of relaxing bowel, including following preparation process：By vegetables and fruits plant
The abundant mixing of fraction addition in proportion of ferment powder, inulin, resistant dextrin, lactitol, common oats fibre, konjaku flour, pineapple juice powder, then
The method that Sucralose, citric acid, probiotic powder are mixed according to gradient is well mixed, the material powder packing machine mixed
Dispensed, be packaged into the product that 8g is often wrapped, often bag ferment probiotics solid beverage dispatches from the factory viable count more than 7 × 109CFU/ bags.
It is required that temperature is 18 DEG C~22 DEG C during production and processing, humidity is 25%~35%.
Eating method：It is dissolved in stirring evenly in 200mL warm water and takes, is please eaten as early as possible after opening.
Embodiment 4：
A kind of ferment probiotics solid tablet with function of relaxing bowel, is made up of the raw material of following parts by weight：
The ferment probiotics solid tablet with function of relaxing bowel, including following preparation process：By vegetables and fruits plant
Ferment powder, inulin, resistant dextrin, xylitol, skimmed milk powder uniformly spray alcoholic solution, are pelletized with granulator, cross 20 mesh sieves, low
Temperature drying, then by the abundant mixing of number addition in proportion of probiotic powder, microcrystalline cellulose, magnesium stearate, silica, then will system
The particle and powder material got ready are well mixed, and 1g every product is pressed into tablet press machine, and bottling was both obtained, and every ferment is prebiotic
The viable count that dispatches from the factory of bacterium solid tablet is more than 2 × 109CFU/.It is required that environment temperature is 18 DEG C~22 DEG C during production and processing, it is wet
Degree is 25%~35%.
Eating method：Warm water is swallowed, and 1 to 2 tablets once, daily 1-3 times, and half an hour is edible before the meal.
Embodiment 5：
A kind of ferment probiotics capsule with function of relaxing bowel, is made up of the raw material of following parts by weight：
The ferment probiotics capsule with function of relaxing bowel, including following preparation process：By vegetables and fruits plant enzyme
The abundant mixing of fraction addition in proportion of powder, inulin, resistant dextrin starch, then the method that probiotic powder is mixed according to gradient are mixed
Uniformly, the material mixed is put into capsule filling machine and is filled, both 0.5g capsule, every ferment probiotics capsule goes out
Factory's viable count is more than 4 × 109CFU/.It is required that temperature is 18 DEG C~22 DEG C during production and processing, humidity is 25%~35%.
Eating method：Warm water is swallowed, one every time, before the meal half an hour take, it is daily 1-3 times.
Embodiment 6：
A kind of ferment probiotics oral liquid with function of relaxing bowel, is made up of the raw material of following parts by weight：
The ferment probiotics oral liquid with function of relaxing bowel, including following preparation process：Xanthans is dissolved in
In appropriate 80 DEG C of water, homogenizer homogeneous is crossed, then is well mixed with concentrated apple juice, honey, remaining water, by vegetables and fruits plant enzyme
Powder, lactitol, inulin, resistant dextrin, which are dissolved in above-mentioned mixed liquor, to be well mixed, then logical retorted 20-30s, to be mixed
Liquid is cooled to room temperature, adds probiotic powder and is well mixed, and mixes feed liquid and is carried out with bottle placer filling, had both obtained every bottle of 10mL
Oral liquid, the viable count that dispatches from the factory of every bottle of ferment probiotics oral liquid is more than 2 × 109CFU/ bottles.
Eating method：Directly drink, one bottle every time, before the meal half an hour take, it is daily 1-3 times.
Animal model checking test：
Test method：Using ferment probiotics capsule of the embodiment 5 with function of relaxing bowel as test group, with toxin-expelling and face nourishing
Soft capsule is control, suppresses model mice and Constipation Model to the small bowel peristalsis that normal mouse and compound diphenoxylate are set up respectively
Mouse carries out contrast experiment.By contrast model Mouse Stomach Intestinal motility and defecation situation, the defaecation effect of embodiment 5 is evaluated
Really.
From adult male mice 60,6 groups, respectively blank control group, model control group, toxin-expelling and face nourishing are randomly divided into
Soft capsule control group, low dosage test group, middle dosage experimental group, high dose test group.
Result of the test：Influence of the ferment probiotics capsule to mouse small intestine propulsion rate is shown in Table 1；To first just time, excrement weight
The influence of amount is shown in Table 2.
Influence of the ferment probiotics capsule of table 1 to mouse small intestine propulsion rate
| Group | Dosage (g/kg) | Equivalent to adult's multiple | Ink progradation (%) |
| Negative control | 69.15±3.18 | ||
| Model comparison | 38.98±2.74 | ||
| Toxin-discharging nourishing capsule | 0.8 | 5 | 70.62±3.37* |
| Low dosage embodiment 5 | 0.325 | 5 | 78.35±6.58* |
| Middle dosage embodiment 5 | 0.65 | 10 | 82.93±4.11** |
| High dose embodiment 5 | 1.95 | 30 | 89.41±4.82** |
Note：* it is to be compared p with model control group<0.05；* is to be compared p with model control group<0.01.
Influence of the ferment probiotics capsule of table 2 to mouse defecation
| Group | Dosage (g/kg) | The first just time (s) | Stool weight (g) |
| Negative control | 137.21±5.39 | 0.78.27±0.06 | |
| Model comparison | 202.75±7.32 | 0.64.±0.05 | |
| Toxin-discharging nourishing capsule | 0.8 | 181.87±6.84 | 0.68±0.06 |
| Low dosage embodiment 5 | 0.325 | 162.83±7.31* | 0.67±0.04 |
| Middle dosage embodiment 5 | 0.65 | 143.59±7.59** | 0.71±0.06 |
| High dose embodiment 5 | 1.95 | 130.97±6.27** | 0.73±0.04 |
Note：* it is to be compared p with model control group<0.05；* is to be compared p with model control group<0.01.
Conclusion (of pressure testing)：The ferment probiotics capsule of embodiment 5 can significantly improve the small intestine prepared Chinese ink that small bowel peristalsis suppresses mouse
Propulsion rate, shows, can remarkably promote the intestines peristalsis function of mouse；The first just time can also be shortened, increase stool interval, with profit
The effect of intestines defaecation.
Model case
Case 1：Female, 31 years old, there is a chronic constipation history for many years, one week defecation 1-2 times, and dry and hard excrement, defecation is not smooth, once in a while
There is a bloody stool, daily to take Western medicine anti-inflammatory more, and used plurality of Chinese or Western medicine product are attempted when constipation is felt bad, defecates logical after medication
Freely, can also suffer from diarrhoea stomachache sometimes, and medicine main suit occurs again after drug withdrawal：There is chronic constipation medical history for many years, take Chinese medicine or Western medicine, greatly
Just it is i.e. unobstructed, recurred after being discontinued, and so on the treatment recurrence several years.First to use after embodiment 1, defaecation in second day is adhered to
Take after one week, defecation is gradually smooth, excrement shaping, and without abdominal pain diarrhea malaise symptoms, adhere to using 1 month, cure without multiple
Hair.
Case 2：Man, 43 years old, has chronic constipation history for many years, often goes on business, and living and diet work and rest is irregular, and eating is dry peppery
Food, once, excrement is hard, is in granular form by 5-7 days rows of natural situation, helps defecation by taking all kinds of medicines relaxed bowel, often
After secondary medication 1-3 days just can defecation, be often accompanied by stomachache or the just symptom of frequency, constipation is more serious after drug withdrawal.Embodiment 1 is taken to count
After hour, there is the sensation of obvious intestines peristalsis, there is awareness of defecation, normally daily defecation, no sense of discomfort, and excrement can be molded after 2-3 days,
Subsequent defecation 5-7 times weekly, after 2 months, not only constipation is cured, and digestive function also take a favorable turn, the symptom of sour regurgitation stomachache
Also there is alleviation.
Case 3：Female, 12 years old, constipation 1 year, 3-5 days defecations had awareness of defecation and difficult defecation, often ate banana, the ease constipation such as honey
The food of defaecation, when and it is when can take a turn for the better and useless.Early to eat embodiment 4 before the meal, defecation after a few hours adheres to early eating before the meal daily
With defecation is smooth every time after 1, one week, first week defecation 5 times adheres to taking that the smooth row of daily getting up early is formed after one month
Just custom.
Case 4：Man, 57 years old, chronic constipation many decades, the symptom such as difficult defecation, defecation be not smooth at an early age was early daily
One glass of hydromel is played, 1-2 root bananas will be eaten tomorrow, and will still be unable to relief of constipation, weekly defecation 2-3 times.Embodiment 4 is taken, it is sooner or later each
After once, second day smooth defecation, the morning and evening, each embodiment 4 adhered to that defecation is smooth after two weeks, defecation 5 times weekly, then
An embodiment 4 is taken in getting up early tomorrow, adheres to 2 months, and constipation is cured, no recurrence.
The know-why of the present invention is described above in association with specific embodiment.These descriptions are intended merely to explain the present invention's
Principle, and limiting the scope of the invention can not be construed in any way.Based on explanation herein, the technology of this area
Personnel, which would not require any inventive effort, can associate other embodiments of the present invention, and these modes are fallen within
Within protection scope of the present invention.
Claims (14)
1. a kind of ferment probiotic composition with function of relaxing bowel, it is characterised in that：Include vegetables and fruits plant enzyme powder,
Probiotics and dietary fiber；
Vegetables and fruits plant enzyme powder drying and grinding after 540 days viable bacteria fermentations by 60 kinds of natural vegetables and fruits cereal and symbiosis probiotics
And obtain；
The probiotics be selected from bifidobacterium longum, animal bifidobacteria, Lactobacillus helveticus, Lactobacillus rhamnosus, lactobacillus acidophilus,
One or more in Lactobacillus plantarum, Lactobacillus casei and Bu Ladi yeast；
The dietary fiber be selected from water-soluble dietary fiber inulin, polydextrose, FOS, galactooligosaccharide, resistant dextrin,
One or more in konjaku flour；Or Water insoluble dietary fiber common oats fibre, Semen Tritici aestivi fiber, zein fiber, soybean fiber, pea
One or more in the luxuriant isapgol husk of beans fiber, circle；Or the combination of water-soluble dietary fiber and Water insoluble dietary fiber；
The mass ratio of the vegetables and fruits plant enzyme powder, probiotics and dietary fiber is (2~60)：(0~2)：(10~80).
2. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：The vegetables and fruits
The preparation process of plant enzyme powder is：Selected fresh mature, non-rot fruits and vegetables, cereal are cleaned, cut into slices, osmotic pressure is extracted
Fermentation, lactic acid deep-fermentation, acetic acid bacteria storage fermentation, afterripening fermentation, concentration, freeze-drying, grinding and obtain；
Described fruits and vegetables include：Banana, tomato, apple, Kiwi berry, pachyrhizus, pineapple, grape, spinach, cabbage, asparagus, grass
The certain kind of berries, lemon, orange, eggplant, wax gourd, pakchoi, guava, balsam pear, corn, lettuce, Sweet Potato Leaf, carambola, three-coloured amaranth, red sugarcane,
Sponge gourd, folium artemisiae argyi, wild cabbage, water-rich areas, grape fruit, crowndaisy chrysanthemum, watermelon, plum, asparagus, broccoli, cabbage mustard, passion fruit, cocoa coconut palm
Son, cumquat, leaf mustard, water spinach, wheat seedling, muskmelon, black fungus, cauliflower, green pepper, carrot, pumpkin, potato, plum, lotus
Mist, cucumber, mushroom, cherry, blue or green river dish, taro, radish；
Described cereal includes：Black soya bean, soya bean, brown rice, mung bean；
The symbiosis probiotics includes saccharomycete, bacillus, lactic acid bacteria, acetic acid bacteria；
540 days described viable bacteria fermentations include four-stage, 180 days extractive fermentation phases, 210 days submerged fermentation phases, storage fermentation
90 days phases, 60 days maturity periods；
The equal single fermentation of described vegetables and fruits plant material is formed after the completion of 540 days according still further to certain ratio chelating；
The moisture requirement of described vegetables and fruits plant enzyme powder is less than 5%.
3. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：It is described prebiotic
Bacterium is Lactobacillus helveticus Rosell-0052, Lactobacillus plantarum Rosell-1012, bifidobacterium longum Rosell-0175, animal pair
Discrimination bacillus LAFTI B94.
4. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：It is described prebiotic
The viable bacteria concentration of bacterium is 1010Cfu/g~5 × 1011cfu/g。
5. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：It is described prebiotic
Each bacterial strain percentage is Lactobacillus helveticus Rosell-0052 in bacterium：Lactobacillus plantarum Rosell-1012：Bifidobacterium longum
Rosell-0175：Animal bifidobacteria LAFTI B94=(10%~60%)：(8%~32%)：(2%~10%)：(30%
~80%).
6. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：The combination
Probiotics viable bacteria concentration in thing is 104Cfu/g~1012Cfu/g, preferably 106Cfu/g~1011Cfu/g, more preferably
108Cfu/g~1010cfu/g。
7. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：The combination
Thing controls temperature at 18 DEG C~22 DEG C in preparation process, and humidity is 25%~35%.
8. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：The meals
Fiber is inulin, resistant dextrin.
9. there is the ferment probiotic composition of function of relaxing bowel as claimed in claim 1, it is characterised in that：The vegetables and fruits
The mass ratio of plant enzyme powder, probiotics and dietary fiber is (25~40)：(0.5~1.5)：(40~70).
10. a kind of application of the ferment probiotic composition with function of relaxing bowel, it is characterised in that：Claim 1~9 times
The ferment probiotic composition with function of relaxing bowel described in one is in the guarantor for preparing defaecation, alleviating or treat purgative function
Application in strong product.
11. a kind of process preparation of the ferment probiotic composition with function of relaxing bowel, it is characterised in that：Including Juice
There is function of relaxing bowel described in powder/slurry, glycitols material, filler, flavouring and any one of claim 1~9
Ferment probiotic composition.
12. there is the process preparation of the ferment probiotic composition of function of relaxing bowel, its feature as claimed in claim 11
It is：The shared mass fraction of the ferment probiotic composition with function of relaxing bowel is 10%~60%.
13. there is the process preparation of the ferment probiotic composition of function of relaxing bowel, its feature as claimed in claim 11
It is：Juice powder/the slurry includes apple juice powder/slurry, grape juice powder/slurry, pineapple juice powder/slurry, lemon juice powder/slurry, strawberry
Juice powder/slurry, orange juice powder/slurry, orange juice powder/slurry, grapefruit juice powder/slurry, mango juice powder/slurry, blueberry juice powder/slurry, Cranberry Juice Cocktail
Powder/slurry, cherry juice powder/slurry, Lychee juice powder/slurry, bananas juice powder/slurry, coconut milk powder/slurry, Cantaloupe juice powder/slurry, peach juice
Powder/slurry, kiwi-fruit juice powder/slurry, pear juice powder/slurry, juice of my pomegranate powder/slurry etc., jujube juice powder/slurry, one kind in oat juice powder/slurry or
It is a variety of；
The glycitols material in xylitol, antierythrite, D-sorbite, mannitol, maltitol, lactitol one
Plant or a variety of；
One or more of the filler in maltodextrin, starch, microcrystalline cellulose, magnesium stearate；
The flavouring includes the one or more in sweetener, acid and essence；
The sweetener is selected from stevioside, Sucralose, Aspartame, acesulfame potassium, mogroside；Honey, fructose syrup, honeybee
One or more in honey, glucose or white granulated sugar；
One or more of the acid in citric acid, malic acid, lactic acid；
The essence is selected from the essence of corresponding fruit powder.
14. there is the process preparation of the ferment probiotic composition of function of relaxing bowel, its feature as claimed in claim 11
It is：The process preparation is solid powder, granule, capsule, oral liquid or tablet.
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