CN106819129A - A kind of children's invigorating the spleen promotees digestion milk piece and preparation method thereof - Google Patents
A kind of children's invigorating the spleen promotees digestion milk piece and preparation method thereof Download PDFInfo
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Abstract
本发明涉及一种儿童健脾促消化奶片及其制备方法,可有效解决儿童消化功能差,易积食的问题。技术方案是,由重量百分比计的:全脂奶粉40~65%,中药提取物30~50%,锌盐1~10%制成;将白术、山楂按照重量比1:1混合,加入2‑5倍重量体积的水,煎煮30‑60分钟得煎煮液,将煎煮液过滤收集滤液,将滤液在真空减压条件下低温浓缩干燥得中药提取物;再将全脂奶粉、中药提取物、锌盐按比例混匀,120℃下灭菌1‑1.5h,压制成片剂即得;本发明针对儿童消化特点,在中医药健脾促消化的基础上,增加改善食欲的锌制剂,既改善了消化问题,又增强机体消化功能,起到标本兼治的效果,并且采用食用片剂,接受度好,食用方便。The invention relates to a milk tablet for invigorating the spleen and promoting digestion for children and a preparation method thereof, which can effectively solve the problems of children with poor digestive function and easy food accumulation. The technical solution is, calculated by weight percentage: 40-65% of whole milk powder, 30-50% of Chinese medicine extract, 1-10% of zinc salt; mix Atractylodes macrocephala and hawthorn in a weight ratio of 1:1, add 2‑ 5 times the weight and volume of water, decocted for 30-60 minutes to obtain the decoction, filtered the decoction to collect the filtrate, concentrated and dried the filtrate at low temperature under vacuum and reduced pressure to obtain the Chinese medicine extract; then extracted whole milk powder and Chinese medicine The product and zinc salt are mixed in proportion, sterilized at 120°C for 1‑1.5h, and pressed into tablets to obtain the product; the present invention aims at children’s digestive characteristics, and adds zinc preparations for improving appetite on the basis of traditional Chinese medicine for invigorating the spleen and promoting digestion. , not only improves digestion problems, but also enhances the digestive function of the body, and has the effect of treating both symptoms and root causes, and adopts edible tablets, which are well accepted and convenient to eat.
Description
技术领域technical field
本发明涉及食品医药领域,特别是一种儿童健脾促消化奶片及其制备方法。The invention relates to the field of food and medicine, in particular to a milk tablet for invigorating spleen and promoting digestion for children and a preparation method thereof.
背景技术Background technique
儿童具有生机蓬勃、发育迅速的特点,但是儿童的消化功能尚未发育成熟,儿童进食后消化及吸收功能相对滞后,容易形成消化不良,中医学称食积,食积是儿童发生其它疾病的重要因素之一。食积的孩子往往伴随有微量元素的改变,其中以血锌水平的低下尤为明显。Children have the characteristics of vigorous vitality and rapid development, but children's digestive function is not yet mature, and children's digestion and absorption functions are relatively lagging behind after eating, and they are prone to indigestion, which is called food accumulation in traditional Chinese medicine, and food accumulation is one of the important factors for children to develop other diseases . Children with food accumulation are often accompanied by changes in trace elements, especially the low blood zinc level.
目前解决方向有两个:被动促进消化功能,大多采用健脾促消化的方法,如健胃消食类的片剂和口服液;主动增强机体消化功能,补充机体所缺成分,增强自身的消化功能,如补锌口服液等。健脾促消化可以解决目前的问题,而补足所缺营养素解决的是长远问题,健脾促消化药物往往是短期服用,停用后易出现反复,而营养素补充剂大多需要长期服用,短期效果并不十分明显,而两者结合可起到标本兼治的效果,但目前尚没有一种既能健脾促消化又能补足所缺营养素,同时又易于儿童接受能够长期食用的药品或保健品。At present, there are two solutions: Passively promote digestion, most of which use the method of invigorating the spleen and promoting digestion, such as tablets and oral liquids for invigorating the stomach and eliminating food; actively enhance the body's digestion function, supplement the body's lack of ingredients, and enhance its own digestion function , such as zinc supplement oral liquid, etc. Invigorating the spleen and promoting digestion can solve the current problem, but supplementing the missing nutrients solves the long-term problem. The drugs for strengthening the spleen and promoting digestion are often taken for a short period of time, and they are prone to relapse after discontinuation. Most nutrient supplements need to be taken for a long time, and the short-term effect is not good. Not very obvious, and the combination of the two can treat both symptoms and root causes, but at present there is no medicine or health product that can strengthen the spleen and promote digestion and can supplement the missing nutrients, and is easy for children to accept and can be taken for a long time.
发明内容Contents of the invention
针对上述情况,为解决现有技术之缺陷,本发明的目的就是提供一种儿童健脾促消化奶片及其制备方法,可有效解决儿童普遍存在的消化功能差,易积食的问题。In view of the above situation, in order to solve the defects of the prior art, the object of the present invention is to provide a milk tablet for invigorating the spleen and promoting digestion for children and a preparation method thereof, which can effectively solve the ubiquitous problems of children with poor digestive function and easy food accumulation.
解决的技术方案是,一种儿童健脾促消化奶片,由重量百分比计的:全脂奶粉40~65%,中药提取物30~50%,锌盐1~10%制成,所述中药提取物为白术和山楂提取物按重量比1:1混合的混合物;所述锌盐为葡萄糖酸锌或柠檬酸锌;将白术、山楂按照重量比1:1混合,加入2-5倍重量体积的水,煎煮30-60分钟得煎煮液,将煎煮液过滤收集滤液,将滤液在真空减压条件下低温浓缩干燥得中药提取物;再将全脂奶粉、中药提取物、锌盐按比例混匀,在120℃下加热1-1.5小时进行灭菌,压制成片剂,得儿童健脾促消化奶片;所述重量体积是指固体按g计,液体按ml计。The technical solution is a children's spleen-invigorating and digestion-promoting milk tablet, which is made by weight percentage: 40-65% of whole milk powder, 30-50% of traditional Chinese medicine extract, and 1-10% of zinc salt. The extract is a mixture of Atractylodes macrocephala and hawthorn extracts in a weight ratio of 1:1; the zinc salt is zinc gluconate or zinc citrate; Atractylodes macrocephala and hawthorn are mixed in a weight ratio of 1:1, and added 2-5 times the weight volume water, decocted for 30-60 minutes to obtain a decoction, filtered the decoction to collect the filtrate, concentrated and dried the filtrate at low temperature under vacuum and reduced pressure to obtain a Chinese medicine extract; then mixed whole milk powder, Chinese medicine extract, zinc salt Mix evenly in proportion, heat at 120° C. for 1-1.5 hours to sterilize, and press into tablets to obtain milk tablets for invigorating spleen and promoting digestion for children; the weight and volume refer to g for solids and ml for liquids.
本发明针对儿童消化功能特点,采用中西医双重促消化的方式,在中医药健脾促消化的基础上,增加改善食欲的锌制剂,着眼于当前和长远的消化功能改善,在双重干预的方式下,既改善了当前的消化问题,又可从长远角度增强机体消化功能,起到标本兼治的效果,并且采用食用方式片剂,外观接近零食,接受度好,食用方便,对儿童消化功能低下,食欲不振等有很好的辅助治疗效果。According to the characteristics of children's digestive function, the present invention adopts the dual method of promoting digestion of traditional Chinese medicine and Western medicine. On the basis of strengthening the spleen and promoting digestion of traditional Chinese medicine, it adds zinc preparations for improving appetite, focusing on the current and long-term improvement of digestive function. It not only improves the current digestive problems, but also enhances the digestive function of the body from a long-term perspective. , loss of appetite, etc. have a good auxiliary therapeutic effect.
具体实施方式detailed description
以下结合实施例对本发明的具体实施方式作详细说明。The specific implementation of the present invention will be described in detail below in conjunction with the examples.
本发明在具体实施中可由以下实施例给出。The present invention can be given by the following examples in specific implementation.
实施例1Example 1
本发明在具体实施中由以下重量百分比计的:全脂奶粉40%,中药提取物50%,葡萄糖酸锌10%制成;将白术、山楂按照重量比1:1混合,加入2倍重量体积的水,煎煮30分钟得煎煮液,将煎煮液过滤收集滤液,将滤液在真空减压条件下低温浓缩干燥得中药提取物;再将全脂奶粉、中药提取物、葡萄糖酸锌按比例混匀,在120℃下加热1小时进行灭菌,压制成片剂,得儿童健脾促消化奶片。In the specific implementation of the present invention, it is made of the following weight percentages: 40% of whole milk powder, 50% of Chinese medicine extract, and 10% of zinc gluconate; mix Atractylodes macrocephala and hawthorn in a weight ratio of 1:1, and add 2 times the weight volume water, decocted for 30 minutes to obtain a decoction, filtered the decoction to collect the filtrate, concentrated and dried the filtrate at low temperature under vacuum and reduced pressure to obtain a Chinese medicine extract; then whole milk powder, Chinese medicine extract, zinc gluconate were pressed Mix evenly, heat at 120°C for 1 hour to sterilize, and press into tablets to obtain children's invigorating spleen and promoting digestion milk tablets.
实施例2Example 2
本发明在具体实施中由以下重量百分比计的:全脂奶粉65%,中药提取物34%,柠檬酸锌盐1%制成,将白术、山楂按照重量比1:1混合,加入5倍重量体积的水,煎煮60分钟得煎煮液,将煎煮液过滤收集滤液,将滤液在真空减压条件下低温浓缩干燥得中药提取物;再将全脂奶粉、中药提取物、柠檬酸锌按比例混匀,在120℃下加热1.5小时进行灭菌,压制成片剂,得儿童健脾促消化奶片。In the specific implementation of the present invention, it is made of the following weight percentages: 65% of whole milk powder, 34% of Chinese medicine extract, and 1% of zinc citrate. Mix Atractylodes macrocephala and hawthorn in a weight ratio of 1:1, and add 5 times the weight volume of water, decocted for 60 minutes to obtain a decoction, filtered the decoction to collect the filtrate, concentrated and dried the filtrate at low temperature under vacuum and reduced pressure to obtain a Chinese medicine extract; then mixed whole milk powder, Chinese medicine extract, zinc citrate Mix evenly in proportion, heat at 120° C. for 1.5 hours to sterilize, and press into tablets to obtain spleen-invigorating and digestion-promoting milk tablets for children.
实施例3Example 3
本发明在具体实施中由以下重量百分比计的:全脂奶粉45%,中药提取物50%,柠檬酸锌5%制成,将白术、山楂按照重量比1:1混合,加入3倍重量体积的水,煎煮50分钟得煎煮液,将煎煮液过滤收集滤液,将滤液在真空减压条件下低温浓缩干燥得中药提取物;再将全脂奶粉、中药提取物、柠檬酸锌按比例混匀,在120℃下加热1小时进行灭菌,压制成片剂,得儿童健脾促消化奶片。In the specific implementation of the present invention, it is made of the following weight percentages: 45% of whole milk powder, 50% of Chinese medicine extract, and 5% of zinc citrate. Atractylodes macrocephala and hawthorn are mixed according to the weight ratio of 1:1, and 3 times the weight volume water, decocted for 50 minutes to obtain a decoction, filtered the decoction to collect the filtrate, concentrated and dried the filtrate at low temperature under vacuum and reduced pressure to obtain a Chinese medicine extract; then whole milk powder, Chinese medicine extract, and zinc citrate were pressed Mix evenly, heat at 120°C for 1 hour to sterilize, and press into tablets to obtain children's invigorating spleen and promoting digestion milk tablets.
实施例4Example 4
本发明在具体实施中由以下重量百分比计的:全脂奶粉60%,中药提取物30%,葡萄糖酸锌10%制成,将白术、山楂按照重量比1:1混合,加入4倍重量体积的水,煎煮40分钟得煎煮液,将煎煮液过滤收集滤液,将滤液在真空减压条件下低温浓缩干燥得中药提取物;再将全脂奶粉、中药提取物、葡萄糖酸锌按比例混匀,在120℃下加热1小时进行灭菌,压制成片剂,得儿童健脾促消化奶片。In the specific implementation of the present invention, it is made of the following weight percentages: 60% of whole milk powder, 30% of Chinese medicine extract, and 10% of zinc gluconate. Atractylodes rhizome and hawthorn are mixed according to the weight ratio of 1:1, and 4 times the weight volume water, decocted for 40 minutes to obtain a decoction, filtered the decoction to collect the filtrate, concentrated and dried the filtrate at low temperature under vacuum and reduced pressure to obtain a Chinese medicine extract; then whole milk powder, Chinese medicine extract, zinc gluconate by Mix evenly, heat at 120°C for 1 hour to sterilize, and press into tablets to obtain children's invigorating spleen and promoting digestion milk tablets.
本发明所述药物:Medicine of the present invention:
白术(学名:Atractylodes macrocephala),是菊科苍术属的一种植物,单叶、狭长,花紫色,头状花序,以根茎入药,别名术、冬术、浙术、种术、祁术等。以根茎入药。性味苦、甘,温。归脾、胃经。功能主治:健脾益气、燥湿利水、止汗、安胎。用于脾虚食少、腹胀泄泻、痰饮眩悸、水肿、自汗、胎动不安,脾虚食少,消化不良,慢性腹泻、水肿、止汗,安胎。Atractylodes macrocephala (scientific name: Atractylodes macrocephala), is a plant of the Atractylodes genus in the family Asteraceae. It has single leaves, long and narrow, purple flowers, and flower heads. Used as medicine with rhizome. Nature and flavor are bitter, sweet, warm. Return spleen, stomach warp. Functions and indications: invigorating the spleen and replenishing qi, drying dampness and diuresis, antiperspirant, anti-abortion. Used for deficiency of the spleen, lack of food, abdominal distention and diarrhea, phlegm and retention, dizziness and palpitations, edema, spontaneous sweating, restless fetal movement, deficiency of the spleen, lack of food, indigestion, chronic diarrhea, edema, antiperspirant, and antifertility.
山楂以果实作药用,性微温,味酸甘,入脾、胃、肝经,有消食健胃、活血化淤、收敛止痢之功能。对肉积痰饮、痞满吞酸、泻痢肠风、腰痛疝气、产后儿枕痛、恶露不尽、小儿乳食停滞等,均有疗效。“山楂,若以甘药佐之,化瘀血而不伤新血,开郁气而不伤正气,其性尤和平也”中医认为山楂具有消积花滞、收敛止痢、活血化淤等功效。山楂中含有的山萜类及黄酮类具有显著的扩张血管及降血压的作用,经常吃山楂还具有曾坚强心肌、抗心律不齐、调节血压及胆固醇的功能。用于治疗小儿消化不良。Hawthorn fruit is used as medicine, mild in nature, sweet and sour in taste, enters the spleen, stomach, and liver meridians, and has the functions of promoting digestion and invigorating the stomach, promoting blood circulation and removing stasis, restraining dysentery. It has curative effects on meat accumulation of phlegm, fullness and sour regurgitation, diarrhea and intestinal wind, low back pain and hernia, pillow pain in postpartum children, endless lochia, stagnation of milk and food in children, etc. "Hawthorn, if it is assisted by sweet medicine, it can remove blood stasis without hurting new blood, open up depression without hurting righteousness, and its nature is especially peaceful." Traditional Chinese medicine believes that hawthorn has the functions of eliminating accumulated flower stagnation, astringent and dysentery, promoting blood circulation and removing stasis, etc. effect. The terpenoids and flavonoids contained in hawthorn can significantly expand blood vessels and lower blood pressure. Regular consumption of hawthorn can also strengthen the heart muscle, resist arrhythmia, regulate blood pressure and cholesterol. For the treatment of indigestion in children.
锌存在于众多的酶系中,如碳酸酐酶,呼吸酶,乳酸脱氢酸,超氧化物歧化酶,碱性磷酸酶,DNA和RNA聚中酶等中,为核酸,蛋白质,碳水化合物的合成和维生素A的利用所必需。锌具有促进生长发育,改善味觉的作用。锌缺乏时出现味觉,嗅觉差,厌食,生长与智力发育低于正常。葡萄糖酸锌和柠檬酸锌为补锌药,主要用于婴儿及老年,妊娠妇女因缺锌引起的生长发育迟缓,营养不良,厌食症,复发性口腔溃疡,皮肤痤疮等症。Zinc exists in many enzyme systems, such as carbonic anhydrase, respiratory enzyme, lactate dehydrogenate, superoxide dismutase, alkaline phosphatase, DNA and RNA polymerase, etc. Necessary for the synthesis and utilization of vitamin A. Zinc can promote growth and development and improve taste. Taste, poor sense of smell, anorexia, growth and mental development are lower than normal in zinc deficiency. Zinc gluconate and zinc citrate are zinc supplements, which are mainly used for infants, the elderly, and pregnant women for growth retardation, malnutrition, anorexia, recurrent oral ulcers, skin acne and other diseases caused by zinc deficiency.
本发明可随身携带,通过日常咀嚼的方式服用,而达到健脾促消化的效果。使用方便,并经人群研究得到了充分证明,有关研究资料如下:The invention can be carried around and taken by daily chewing, so as to achieve the effect of invigorating the spleen and promoting digestion. It is easy to use and has been fully proved by population studies. The relevant research information is as follows:
1对象选择1 object selection
1.1选取某幼儿园大班儿童,按班级随机分为两组:对照组36例,男19例,女17例,年龄为5.5士1.3岁;治疗组35例,男15例,女15例,年龄为5.6士1.1岁。两组性别、年龄比较无统计学差异,具有可比性。1.1 Select the children in the top class of a certain kindergarten, and be randomly divided into two groups according to the class: 36 examples of the control group, 19 examples of men, 17 examples of women, aged 5.5 ± 1.3 years; 35 examples of the treatment group, 15 examples of men, 15 examples of women, aged 5.6 ± 1.1 years old. There was no statistical difference in gender and age between the two groups, and they were comparable.
1.2纳入标准:该幼儿园大班儿童。1.2 Inclusion criteria: Children in the top class of the kindergarten.
1.3排除标准:对奶片中任一成分过敏者,孩子或家长拒绝参与者。1.3 Exclusion criteria: Those who are allergic to any ingredient in milk tablets, children or parents refuse to participate.
2试验方法:2 Test method:
2.1治疗方案:将符合研究标准的儿童按班级随机分为治疗组与对照组,治疗组儿童服用本发明奶片10g/天,连续食用30天。对照组儿童食用普通奶片10g/天,连续食用30天。1个月后随访。由幼儿园老师记录孩子的进食情况。2.1 Treatment plan: Children who meet the research criteria are randomly divided into a treatment group and a control group according to their classes, and the children in the treatment group take 10 g/day of the milk tablet of the present invention for 30 consecutive days. Children in the control group ate ordinary milk tablets 10g/day for 30 consecutive days. Follow up visit after 1 month. The children's food intake was recorded by the kindergarten teacher.
2.2观察指标 孩子的食欲情况,由孩子家长和幼儿园老师同时提供,两者一致视为改善;孩子体重增加值,试验开始和试验结束分别测体重,计算两者的差值。2.2 Observation indicators The child's appetite was provided by the child's parents and the kindergarten teacher at the same time, and both were deemed to be improved; the child's weight gain was measured at the beginning and end of the test, and the difference between the two was calculated.
2.3数据处理 采用SPSS13.0进行统计分析,食欲改善采用卡方检验进行分析,体重采用t检验进行分析,以α=0.05作为检验水准。2.3 Data processing SPSS13.0 was used for statistical analysis, chi-square test was used for appetite improvement, and t test was used for body weight analysis, with α=0.05 as the test level.
3 结果3 results
两组儿童在服用奶片30天后,治疗组体重增长和食欲改善情况好于对照组,结果见表1和表2.After the two groups of children took milk tablets for 30 days, the weight gain and appetite improvement of the treatment group were better than those of the control group. The results are shown in Table 1 and Table 2.
表1 两组儿童体重增长情况Table 1 Weight gain of two groups of children
t=2.059 P=0.043 t =2.059 P =0.043
表2 两组儿童食欲改善情况Table 2 The improvement of appetite in the two groups of children
X 2 =7.002 P=0.008 X 2 =7.002 P =0.008
4结论4 Conclusion
本发明具有改善食欲,促进生长发育的功效。The invention has the effects of improving appetite and promoting growth and development.
本发明针对儿童消化功能特点,采用中西医双重促消化的方式,在中医药健脾促消化的基础上,增加改善食欲的锌制剂,着眼于当前和长远的消化功能改善,在双重干预的方式下,既改善了当前的消化问题,又可从长远角度增强机体消化功能,起到标本兼治的效果,并且采用食用方式片剂,外观接近零食,接受度好,食用方便,对儿童消化功能低下,食欲不振等有很好的辅助治疗效果。According to the characteristics of children's digestive function, the present invention adopts the dual method of promoting digestion of traditional Chinese medicine and Western medicine. On the basis of strengthening the spleen and promoting digestion of traditional Chinese medicine, it adds zinc preparations for improving appetite, focusing on the current and long-term improvement of digestive function. It not only improves the current digestive problems, but also enhances the digestive function of the body from a long-term perspective. , loss of appetite, etc. have a good auxiliary therapeutic effect.
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CN101485839A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicament preparation for preventing and treating children's malnutrition and preparation method thereof |
CN103504004A (en) * | 2012-06-16 | 2014-01-15 | 重庆市彭水县彭双科技有限公司 | Method for producing nutrition milk tablets |
CN103918794A (en) * | 2014-04-10 | 2014-07-16 | 陕西科技大学 | Goat milk tablets with functions of invigorating stomach and helping digestion, and preparation method thereof |
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CN101485839A (en) * | 2008-01-16 | 2009-07-22 | 北京天科仁祥医药科技有限公司 | Chinese medicament preparation for preventing and treating children's malnutrition and preparation method thereof |
CN103504004A (en) * | 2012-06-16 | 2014-01-15 | 重庆市彭水县彭双科技有限公司 | Method for producing nutrition milk tablets |
CN103918794A (en) * | 2014-04-10 | 2014-07-16 | 陕西科技大学 | Goat milk tablets with functions of invigorating stomach and helping digestion, and preparation method thereof |
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