CN106508934A - Fungicidal composition containing benthiavalicarb-isopropyl and amobam and application thereof - Google Patents
Fungicidal composition containing benthiavalicarb-isopropyl and amobam and application thereof Download PDFInfo
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- CN106508934A CN106508934A CN201510587470.7A CN201510587470A CN106508934A CN 106508934 A CN106508934 A CN 106508934A CN 201510587470 A CN201510587470 A CN 201510587470A CN 106508934 A CN106508934 A CN 106508934A
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- China
- Prior art keywords
- ambam
- composition containing
- benzene metsulfovax
- bactericidal composition
- metsulfovax
- Prior art date
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- FROZIYRKKUFAOC-UHFFFAOYSA-N amobam Chemical compound N.N.SC(=S)NCCNC(S)=S FROZIYRKKUFAOC-UHFFFAOYSA-N 0.000 title claims abstract description 57
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- USRKFGIXLGKMKU-ABAIWWIYSA-N benthiavalicarb-isopropyl Chemical compound C1=C(F)C=C2SC([C@@H](C)NC(=O)[C@H](C(C)C)NC(=O)OC(C)C)=NC2=C1 USRKFGIXLGKMKU-ABAIWWIYSA-N 0.000 title abstract description 6
- 230000000855 fungicidal effect Effects 0.000 title abstract 6
- 239000003814 drug Substances 0.000 claims abstract description 15
- 208000031888 Mycoses Diseases 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 9
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 5
- 241000918585 Pythium aphanidermatum Species 0.000 claims abstract 2
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 189
- UDSJPFPDKCMYBD-UHFFFAOYSA-N Metsulfovax Chemical compound S1C(C)=NC(C)=C1C(=O)NC1=CC=CC=C1 UDSJPFPDKCMYBD-UHFFFAOYSA-N 0.000 claims description 47
- 230000000844 anti-bacterial effect Effects 0.000 claims description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 241000894006 Bacteria Species 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 10
- 239000000839 emulsion Substances 0.000 claims description 8
- 241001272684 Xanthomonas campestris pv. oryzae Species 0.000 claims description 7
- 150000001412 amines Chemical class 0.000 claims description 7
- UGYRYNXDEOFIQB-UHFFFAOYSA-N benzene thiophene Chemical compound S1C=CC=C1.C1=CC=CC=C1.C1=CC=CC=C1 UGYRYNXDEOFIQB-UHFFFAOYSA-N 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 6
- 241000196324 Embryophyta Species 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000000375 suspending agent Substances 0.000 claims description 5
- 239000004563 wettable powder Substances 0.000 claims description 5
- 239000006185 dispersion Substances 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 239000004530 micro-emulsion Substances 0.000 claims description 4
- 241000193738 Bacillus anthracis Species 0.000 claims description 3
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 239000000575 pesticide Substances 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000002917 insecticide Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 14
- 239000003795 chemical substances by application Substances 0.000 abstract description 13
- 230000002195 synergetic effect Effects 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract description 4
- 235000013311 vegetables Nutrition 0.000 abstract description 4
- 235000013339 cereals Nutrition 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 244000052769 pathogen Species 0.000 abstract description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 17
- -1 diffusant Substances 0.000 description 16
- 238000000034 method Methods 0.000 description 15
- 239000004615 ingredient Substances 0.000 description 13
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- 229940051841 polyoxyethylene ether Drugs 0.000 description 10
- 229920000056 polyoxyethylene ether Polymers 0.000 description 10
- 239000002994 raw material Substances 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 229910019142 PO4 Inorganic materials 0.000 description 6
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 6
- 235000021317 phosphate Nutrition 0.000 description 6
- 230000000295 complement effect Effects 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 210000000481 breast Anatomy 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 230000002265 prevention Effects 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 241000233866 Fungi Species 0.000 description 3
- 241000209094 Oryza Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 239000002270 dispersing agent Substances 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 2
- 244000299507 Gossypium hirsutum Species 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 241000233629 Phytophthora parasitica Species 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 125000003368 amide group Chemical group 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 150000002190 fatty acyls Chemical group 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 229910052622 kaolinite Inorganic materials 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 229940068984 polyvinyl alcohol Drugs 0.000 description 2
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 2
- 230000007115 recruitment Effects 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 2
- 239000002689 soil Substances 0.000 description 2
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- KBRSJPHSCOAFDR-UHFFFAOYSA-N 3-chloro-6-methyl-5,5-dioxo-11h-benzo[c][2,1]benzothiazepin-11-ol Chemical compound O=S1(=O)N(C)C2=CC=CC=C2C(O)C2=CC=C(Cl)C=C21 KBRSJPHSCOAFDR-UHFFFAOYSA-N 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 244000186561 Swietenia macrophylla Species 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 125000002877 alkyl aryl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical group O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- PYLWMHQQBFSUBP-UHFFFAOYSA-N monofluorobenzene Chemical compound FC1=CC=CC=C1 PYLWMHQQBFSUBP-UHFFFAOYSA-N 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a fungicidal composition containing benthiavalicarb-isopropyl and amobam and application thereof. The fungicidal composition containing benthiavalicarb-isopropyl and amobam takes benthiavalicarb-isopropyl and amobam as the main active ingredients, and the benthiavalicarb-isopropyl and amobam are in a weight ratio of 1-70:1-50. The invention also discloses application of the fungicidal composition in preparation of drugs for controlling fungal diseases in resistant plants, can be applied to control of cereal, fruit tree and vegetable diseases, has high synergistic effect, can overcome and delay drug resistance of pathogens, has fast fungicidal speed and long duration, lowers the application cost, and has a control effect obviously superior to that of a single agent. The fungicidal composition provided by the invention can be used for controlling fungal diseases in crops, is especially suitable for control of late blight, downy mildew, damping-off, leaf blight, anthracnose and other fungal diseases, and has a effect better than that of a single agent.
Description
Technical field
The present invention relates to a kind of bactericidal composition and application thereof, especially a kind of bactericidal composition containing benzene metsulfovax and ambam and
Its application.
Background technology
Benzene metsulfovax (benthiavalicarb-isopropyl), molecular formula：C18H24FN3O3S, chemical name：[[(6- fluorobenzene is simultaneously
Thiazol-2-yl)-ethylaminocarbonyl] -2- methyl-propyls] carbamic acid isopropyl ester.
Benzene metsulfovax have good bactericidal activity to phytophthora root rot, to its sporangial formation, sporangial sprouting at low concentrations
There is good inhibiting effect, but the release to zoospore and the movement of zoospore are not acted on.In field test, benzene thiophene bacterium
Amine is with relatively low dosage (25～75g a.i./hm2) can effectively control late blight, Fructus Vitis viniferae and other crops of Rhizoma Solani tuber osi and Fructus Lycopersici esculenti
Downy mildew.
Ambam (Amobam), molecular formula：C4H14N4S4, chemical name：Ethylene bisdithiocarbamic ammonium,
Chemical structural formula：
Ambam belongs to organic sulphur preparation, can be used to prevent and treat bacterial blight of rice, cotton anthracnose, cotton seedling blight and some vegetables
Dish, fruit diseases etc..
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, with economy such as the change of pattern of farming, melon fruits and vegetables
Crops planting area progressively expands, and disease occurrence degree, generation quantity increase, and in preventing and treating, difficulty is increased；The opposing party
Face, the resistance of pathogen rise under lasting medicament selection pressure year by year, and the prevention effect of single dose is had a greatly reduced quality, plant disease
Preventing and treating is faced with significant challenge.
The content of the invention
The purpose of the present invention be for above-mentioned technical problem provide a kind of applied widely, low cost, effect it is good containing benzene metsulfovax
With the plant bactericidal composition of ambam.
The purpose of the present invention is realized by following measures：
A kind of bactericidal composition containing benzene metsulfovax and ambam, it is with benzene metsulfovax and ambam as main active, described
Benzene metsulfovax and ambam weight ratio be 1～70：1～50, wherein in bactericidal composition, active ingredient is deposited with enhancing effective amount
In being compositionss.
In bactericidal composition of the present invention, the weight ratio preferably 5～50 of described benzene metsulfovax and ambam：10～
50, more preferably 5～40：10～50, most preferably 1：2～10.
In bactericidal composition of the present invention, both described benzene metsulfovax and ambam account for the weight percentage of compositionss
For 2～80%, preferably 5.5～70%.
Described bactericidal composition is with benzene metsulfovax and ambam as principle active component and known auxiliary agent and excipient are re-dubbed agriculture
Any one dosage form allowed on medicine.Auxiliary agent, excipient known to these have dispersant, diffusant, defoamer, wetting agent,
Disintegrating agent etc., can be using to methoxyl group fatty acyl amido benzene sulfonic acid sodium salt, sodium methylene bis-naphthalene sulfonate, DBSA
Calcium, alkylphenol polyoxyethylene, alkylaryl polyoxyethylene polyoxypropylene ether again, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyoxy
Vinyl Ether, three phenethyl phenol polyoxyethylene ether phosphates, fatty alcohol-polyoxyethylene ether and its similar products, aliphatic amine polyoxyethylene
Ether, fatty acid ethylene oxide addition product, polyoxyethylene polyoxypropylene block compound, castor oil polyoxyethylene ether, nonyl phenol gather
Oxygen vinyl Ether, TWEEN Series, Polyethylene Glycol series, Sulfonateses, carboxylate, sulfate, phosphate, phosphite, wood
One or more combinations in mahogany sulfonate, xanthan gum, phenol formaldehyde condensate, ammonium salt, quaternary etc., excipient include
Ketohexamethylene, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as Propylene Glycol), deionized water etc..Above auxiliary agent, excipient
And other adjuvants can be with alone or be used in combination.
Described dosage form is cream, wettable powder, suspending agent, aqueous emulsion, microemulsion or water dispersion granule.
It is a still further object of the present invention to provide the bactericidal composition causes on fungal disease medicine in preparation preventing and treating resistance plant funguses
Application.Preferably, described bactericidal composition is preparing preventing and treating Cereal, fruit tree, vegetable crop refractory fungal disease medicine
The application of aspect, especially prevents and treats late blight, downy mildew, damping-off, leaf blight, anthrax, bacterial leaf-blight etc. in preparation true
Application on fungus diseases medicine, is most preferably preparing the application prevented and treated on bacterial blight of rice medicine.Described bactericidal composition pair
Above-mentioned resistance plant fungal disease is respectively provided with significant effect, can produce higher synergistic function.
Compared with prior art, beneficial effects of the present invention：
(1), compared with single dose, the bactericidal composition scope of application of the present invention increases, and expands preventing and treating spectrum, it is adaptable to prevent and treat cereal
Class, fruit tree, the refractory fungal disease of vegetable, have preventing and treating effect well to ascomycetess, basidiomycetes, Fungi Imperfecti fungal disease
Really, it is particularly suitable for preventing and treating late blight, downy mildew, damping-off, leaf blight, anthrax, bacterial leaf-blight, is respectively provided with significantly
Effect, higher synergistic function can be produced.
(2), compared with single dose, overcome and delayed Drug resistance, funguses can be suppressed to unitary agent (benzene metsulfovax and Dai Sen
Ammonium is arbitrary) drug-fast generation, alternative routine and be also easy to produce the pesticide of resistance.
(3), the consumption of the amount ratio independent reactive compound of bactericidal composition of the present invention is substantially reduced, i.e. the activity of mixture is big
In the activity of independent component, compared with single dose, preventing and treating recruitment, drug cost is reduced.
Specific embodiment
With reference to embodiments technical scheme is described further, two kinds of reactive compounds can be processed into permission
Any one dosage form, but the preparation that can process of the two kinds of active components be not limited only to it is set forth below.The system of dosage form in embodiment
Preparation Method is conventional method.
" % " of the present invention is weight percentage.
Embodiment 1
Weigh benzene metsulfovax 5g, ambam 10g, detergent LS (to methoxyl group fatty acyl amido benzene sulfonic acid sodium salt) 2g, diffusion
Agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, Kaolin add to 100g, and mixture carries out comminution by gas stream, system
It is 15% benzene metsulfovax-ambam wettable powder to obtain effective ingredient weight percentage.
Embodiment 2
Weigh benzene metsulfovax 3g, ambam 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite
Soil adds to 100g, and mixture carries out comminution by gas stream, and it is 15% benzene metsulfovax-ambam that effective ingredient weight percentage is obtained
Wettable powder.
Embodiment 3
Weigh benzene metsulfovax 2g, ambam 14g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, kaolinite
Soil adds to 100g, and mixture carries out comminution by gas stream, and it is 16% benzene metsulfovax-ambam that effective ingredient weight percentage is obtained
Wettable powder.
Embodiment 4
Weigh benzene metsulfovax 5g, ambam 50g, three phenethyl phenol polyoxyethylene ether phosphate 3g, agriculture breast 33# (alkyl virtue
Base polyoxyethylene polyoxypropylene ether) 2g, alkylphenol polyoxyethylene 1g, 200# solvent naphtha 13g, add water to 100g.Will be with
Upper raw material routinely prepares the method input mixing kettle high speed mixing of aqueous emulsion, makes effective Ingredients Weight percentage composition for 55%
Benzene metsulfovax-ambam aqueous emulsion.
Embodiment 5
Weigh benzene metsulfovax 2g, ambam 30g, calcium dodecyl benzene sulfonate 6g, three phenethyl phenol polyoxyethylene ether phosphates
3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is routinely matched somebody with somebody
Mix in the method input mixing kettle of microemulsion processed, it is that 32% benzene metsulfovax-ambam is micro- to make effective Ingredients Weight percentage composition
Emulsion.
Embodiment 6
Weigh benzene metsulfovax 1g, ambam 5g, three phenethyl phenol polyoxyethylene ether phosphate 3g, agriculture breast 33#2g, alkyl phenol
Polyoxyethylene ether 1g, 200# solvent naphtha 13g, adds water to 100g.Above raw material is routinely prepared into the method input of aqueous emulsion
Mixing kettle high speed mixes, and makes effective Ingredients Weight percentage composition for 6% benzene metsulfovax-ambam aqueous emulsion.
Embodiment 7
Weigh benzene metsulfovax 50g, ambam 20g, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, Semen Ricini
Oily polyoxyethylene ether 2g, plus 200# solvent naphthas are to 100g.Above raw material is routinely prepared in the method input mixing kettle of cream
Mixing, makes effective Ingredients Weight percentage composition for 70% benzene metsulfovax-ambam cream.
Embodiment 8
Benzene metsulfovax 2g, ambam 40g, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g is weighed, plus
200# solvent naphthas are to 100g.Mix in the method input mixing kettle that above raw material is routinely prepared cream, make effective ingredient
Weight percentage is 42% benzene metsulfovax-ambam cream.
Embodiment 9
Weigh benzene metsulfovax 5g, ambam 20g, calcium dodecyl benzene sulfonate 6g, three phenethyl phenol polyoxyethylene ether phosphates
3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.Above raw material is routinely matched somebody with somebody
Mix in the method input mixing kettle of microemulsion processed, it is that 25% benzene metsulfovax-ambam is micro- to make effective Ingredients Weight percentage composition
Emulsion.
Embodiment 10
Benzene metsulfovax 5g, ambam 0.5g, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g is weighed, plus
200# solvent naphthas are to 100g.Mix in the method input mixing kettle that above raw material is routinely prepared cream, make effective ingredient
Weight percentage is 5.5% benzene metsulfovax-ambam cream.
Embodiment 11
Benzene metsulfovax 5g, ambam 30g, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g is weighed, plus
200# solvent naphthas are to 100g.Mix in the method input mixing kettle that above raw material is routinely prepared cream, make effective ingredient
Weight percentage is 35% benzene metsulfovax-ambam cream.
Embodiment 12
Weigh benzene metsulfovax 10g, ambam 10g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthan gum 0.15g,
Ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, make in the presence of sand mill effectively into
Weight percentage is divided to be 20% benzene metsulfovax-ambam suspending agent.
Embodiment 13
Weigh benzene metsulfovax 30g, ambam 12g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthan gum 0.15g,
Ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, make in the presence of sand mill effectively into
Weight percentage is divided to be 42% benzene metsulfovax-ambam suspending agent.
Embodiment 14
Weigh benzene metsulfovax 2g, ambam 5g, sodium lignin sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, poly-
Vinyl alcohol 5g, Borax 2g, white carbon 3g, kieselguhr complement to 100g, and above raw material is made by water dispersible granular agent method
Effective ingredient weight percentage is 7% benzene metsulfovax-ambam water dispersion granule.
Embodiment 15
Weigh benzene metsulfovax 4g, ambam 13g, sodium lignin sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, poly-
Vinyl alcohol 5g, Borax 2g, kieselguhr complement to 100g, and above raw material is formed with imitating composition by water dispersible granular agent method
Weight percentage is 17% benzene metsulfovax-ambam water dispersion granule.
Embodiment 16
Weigh benzene metsulfovax 5g, ambam 15g, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthan gum 0.15g, second
Glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, make effective ingredient in the presence of sand mill
Weight percentage is 20% benzene metsulfovax-ambam suspending agent.
Embodiment 17
Indoor biometricses are tested：
Mycelial growth rate method is adopted indoors, determines different agents to rice leaf spot bacteria strain (Xanthomonas oryzae
PV.oryzae EC)50Value, using co-toxicity coefficient computational methods, calculates the co-toxicity coefficient (CTC) of mixture, it is determined that mixed
Agent it is building performance, circular is as follows：
With in mixture, a certain single dose (generally selects EC as standard agent50Junior), calculated：
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Toxicity index × the B of the toxicity index of theoretical toxicity index=A single doses × A single doses proportion+B single doses in mixture is mono-
Agent proportion in mixture
The EC of actual measurement toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：When CTC is more than 120, mixture has synergetic, and CTC exists for antagonism, CTC when being less than 80
It is summation action between 80-120.
Table 1：Indoor biometricses result of the benzene metsulfovax+ambam different ratio to rice leaf spot bacteria strain
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| Benzene metsulfovax (A) | Y=1.34X+3.99 | 5.632 | - |
| Ambam (B) | Y=1.62X+3.23 | 12.456 | - |
| A:B=80:1 | Y=2.30X+2.61 | 10.952 | 114.51 |
| A:B=1:2 | Y=2.78X+1.95 | 12.551 | 156.34 |
| A:B=1:4 | Y=2.96X+1.87 | 11.384 | 194.78 |
| A:B=1:6 | Y=1.31X+3.64 | 11.015 | 213.20 |
| A:B=1:10 | Y=1.90X+2.74 | 15.496 | 160.14 |
| A:B=1:60 | Y=2.99X+0.75 | 26.423 | 102.23 |
| A:B=1:70 | Y=1.87X+2.32 | 27.124 | 99.86 |
1 indoor biometricses of table test result indicate that, benzene metsulfovax and ambam weight ratio are 1～70：1～50 compositionss are malicious altogether
Coefficient is both greater than 120, has obvious synergistic function to rice leaf spot bacteria.
Field control effectiveness test：
Carried out preventing and treating bacterial blight of rice test with pesticidal preparations obtained in above-described embodiment.
1st, test process：This test medicine consumption sets three concentration for the treatment of, comparison medicament point respectively according to the difference of each composition
It is not 15% benzene metsulfovax WP of pesticide single dose and 50% ambam WP and blank clean water experiment.
2nd, test method：Each plot area is 66.7m2, it is repeated 3 times；Investigation drug effect side after investigating and prevent and treat before dispenser
Method is：5 points of randomization (takes 5m per in the test process area2), the state of an illness is carried out according to national field test relevant criterion
Classification, calculates preventive effect.
3rd, result of the test see the table below：
Table 2：Field efficacy result of the benzene metsulfovax+ambam different ratio to bacterial blight of rice
As shown in Table 2：Compared with single dose, benzene metsulfovax and ambam compositionss have significant effect to bacterial blight of rice,
Higher synergistic function can be produced.The consumption of the amount ratio independent reactive compound of bactericidal composition is substantially reduced, that is, mix
Activity of the activity of thing more than independent component, compared with single dose, reduces preventing and treating recruitment, drug cost.
Shown by indoor biometricses and field efficacy result, benzene metsulfovax there is obvious Synergistic to make with ambam compositionss
With the prevention effect of compositionss is excellent, and prevention effect is better than single dose kind, in agricultural application has using value.
Claims (10)
1. a kind of bactericidal composition containing benzene metsulfovax and ambam, it is characterised in that it is main with benzene metsulfovax and ambam
Active component, described benzene metsulfovax are 1～70 with ambam weight ratio：1～50.
2. the bactericidal composition containing benzene metsulfovax and ambam according to claim 1, it is characterised in that described benzene thiophene
Bacterium amine is 5～50 with the weight ratio of ambam：10～50.
3. the bactericidal composition containing benzene metsulfovax and ambam according to claim 2, it is characterised in that described benzene thiophene
The weight ratio of bacterium amine and ambam is 5～40：10～50.
4. the bactericidal composition containing benzene metsulfovax and ambam according to claim 3, it is characterised in that described benzene thiophene
The weight ratio of bacterium amine and ambam is 1：2～10.
5. the bactericidal composition containing benzene metsulfovax and ambam according to claim 1, it is characterised in that described benzene thiophene
It is 2～80% that both bacterium amine and ambam account for the weight percentage of compositionss.
6. the bactericidal composition containing benzene metsulfovax and ambam according to claim 5, it is characterised in that described benzene thiophene
It is 5.5～70% that both bacterium amine and ambam account for the weight percentage of compositionss.
7. the bactericidal composition containing benzene metsulfovax and ambam according to claim 1, it is characterised in that it is with benzene thiophene bacterium
Amine and ambam are that principle active component and insecticides adjuvant, excipient are configured to any one dosage form allow on pesticide.
8. the bactericidal composition containing benzene metsulfovax and ambam according to claim 7, it is characterised in that described dosage form
It is cream, suspending agent, aqueous emulsion, wettable powder, microemulsion or water dispersion granule.
9. the bactericidal composition containing benzene metsulfovax and ambam described in claim 1 is preparing preventing and treating resistance plant fungal disease
Application on medicine.
10. the bactericidal composition containing benzene metsulfovax and ambam described in claim 1 preparation prevent and treat late blight, downy mildew,
Application on damping-off, leaf blight, anthrax, bacterial leaf-blight medicine, preferably prevents and treats on bacterial blight of rice medicine in preparation
Using.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919251A (en) * | 2012-11-24 | 2013-02-13 | 陕西农心作物科技有限公司 | Bactericidal composition containing benthiavalicarb isopropyl and captan |
| CN103734160A (en) * | 2013-12-08 | 2014-04-23 | 海利尔药业集团股份有限公司 | Sterilization composition containing benthiavalicarb isopropyl and zineb |
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2015
- 2015-09-15 CN CN201510587470.7A patent/CN106508934A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102919251A (en) * | 2012-11-24 | 2013-02-13 | 陕西农心作物科技有限公司 | Bactericidal composition containing benthiavalicarb isopropyl and captan |
| CN103734160A (en) * | 2013-12-08 | 2014-04-23 | 海利尔药业集团股份有限公司 | Sterilization composition containing benthiavalicarb isopropyl and zineb |
Non-Patent Citations (1)
| Title |
|---|
| 陈启辉: "新型杀菌剂苯噻菌胺", 《农药》 * |
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