CN105831131A - Bactericidal composition containing fluxapyroxad and thiabendazole and application thereof - Google Patents
Bactericidal composition containing fluxapyroxad and thiabendazole and application thereof Download PDFInfo
- Publication number
- CN105831131A CN105831131A CN201610266240.5A CN201610266240A CN105831131A CN 105831131 A CN105831131 A CN 105831131A CN 201610266240 A CN201610266240 A CN 201610266240A CN 105831131 A CN105831131 A CN 105831131A
- Authority
- CN
- China
- Prior art keywords
- fluxapyroxad
- probenazole
- bactericidal composition
- thiabendazole
- application
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005788 Fluxapyroxad Substances 0.000 title claims abstract description 76
- SXSGXWCSHSVPGB-UHFFFAOYSA-N fluxapyroxad Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=CC=C1C1=CC(F)=C(F)C(F)=C1 SXSGXWCSHSVPGB-UHFFFAOYSA-N 0.000 title claims abstract description 76
- 239000000203 mixture Substances 0.000 title claims abstract description 57
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 32
- 239000004308 thiabendazole Substances 0.000 title abstract description 5
- 235000010296 thiabendazole Nutrition 0.000 title abstract description 5
- WJCNZQLZVWNLKY-UHFFFAOYSA-N thiabendazole Chemical compound S1C=NC(C=2NC3=CC=CC=C3N=2)=C1 WJCNZQLZVWNLKY-UHFFFAOYSA-N 0.000 title abstract description 5
- 229960004546 thiabendazole Drugs 0.000 title abstract description 5
- 208000031888 Mycoses Diseases 0.000 claims abstract description 13
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 12
- 201000010099 disease Diseases 0.000 claims abstract description 11
- 241000221785 Erysiphales Species 0.000 claims abstract description 6
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 6
- 235000009566 rice Nutrition 0.000 claims abstract description 6
- 240000007594 Oryza sativa Species 0.000 claims abstract 2
- WHHIPMZEDGBUCC-UHFFFAOYSA-N probenazole Chemical group C1=CC=C2C(OCC=C)=NS(=O)(=O)C2=C1 WHHIPMZEDGBUCC-UHFFFAOYSA-N 0.000 claims description 77
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 239000004615 ingredient Substances 0.000 claims description 19
- 239000006071 cream Substances 0.000 claims description 14
- 241000220324 Pyrus Species 0.000 claims description 8
- 239000000839 emulsion Substances 0.000 claims description 8
- 235000021017 pears Nutrition 0.000 claims description 8
- 239000000375 suspending agent Substances 0.000 claims description 8
- 239000004563 wettable powder Substances 0.000 claims description 8
- 241000193738 Bacillus anthracis Species 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 7
- 241000196324 Embryophyta Species 0.000 claims description 7
- 239000006185 dispersion Substances 0.000 claims description 7
- 239000003814 drug Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 241001530056 Athelia rolfsii Species 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 6
- WHDHEVMINMZADQ-UHFFFAOYSA-N [F].N1C=CC=C1 Chemical class [F].N1C=CC=C1 WHDHEVMINMZADQ-UHFFFAOYSA-N 0.000 claims description 4
- 239000000575 pesticide Substances 0.000 claims description 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 4
- 150000001408 amides Chemical class 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000002917 insecticide Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 21
- 239000003795 chemical substances by application Substances 0.000 abstract description 11
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 235000013339 cereals Nutrition 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 235000014443 Pyrus communis Nutrition 0.000 abstract 1
- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 27
- 238000002156 mixing Methods 0.000 description 18
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- 238000000034 method Methods 0.000 description 15
- -1 diffusant Substances 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 239000004530 micro-emulsion Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 8
- 230000002265 prevention Effects 0.000 description 7
- 239000002904 solvent Substances 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229920000056 polyoxyethylene ether Polymers 0.000 description 6
- 229940051841 polyoxyethylene ether Drugs 0.000 description 6
- 210000000481 breast Anatomy 0.000 description 5
- 230000000295 complement effect Effects 0.000 description 5
- 241000233866 Fungi Species 0.000 description 4
- 241000209094 Oryza Species 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 description 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000002270 dispersing agent Substances 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- 229910019142 PO4 Inorganic materials 0.000 description 3
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- 238000003801 milling Methods 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 3
- 239000010452 phosphate Substances 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 239000000377 silicon dioxide Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 241000235349 Ascomycota Species 0.000 description 2
- 241000221198 Basidiomycota Species 0.000 description 2
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- 125000002252 acyl group Chemical group 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 150000003851 azoles Chemical class 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 235000012055 fruits and vegetables Nutrition 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 229930192474 thiophene Natural products 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- ZVXKYWHJBYIYNI-UHFFFAOYSA-N 1h-pyrazole-4-carboxamide Chemical compound NC(=O)C=1C=NNC=1 ZVXKYWHJBYIYNI-UHFFFAOYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- GFPSTSCYNCOYTN-UHFFFAOYSA-N 6-phenylimidazo[2,1-b][1,3,4]thiadiazole Chemical compound N1=C2SC=NN2C=C1C1=CC=CC=C1 GFPSTSCYNCOYTN-UHFFFAOYSA-N 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 241001529387 Colletotrichum gloeosporioides Species 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 102000019259 Succinate Dehydrogenase Human genes 0.000 description 1
- 108010012901 Succinate Dehydrogenase Proteins 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical group O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing fluxapyroxad and thiabendazole and an application thereof. The bactericidal composition takes fluxapyroxad and thiabendazole as main active ingredients, wherein the mass ratio of fluxapyroxad to thiabendazole is (1-70) to (1-50). The bactericidal composition can be used for controlling cereal, fruit tree and vegetable diseases, has higher synergistic effects, has the effects of overcoming and delaying the drug resistance of germs, has a high bactericidal speed and a long lasting period, has the effect of reducing the application cost and has obviously better control effects than single agents. The bactericidal composition can be used for controlling fungal diseases on crops, especially fungal diseases, such as sheath blight, gray mold, rice bakanae diseases, pear powdery mildew, anthracnose, and the like, and has obviously better effects than single agents.
Description
Technical field:
The present invention relates to a kind of bactericidal composition and application thereof, especially one live with fluxapyroxad and probenazole for main
The bactericidal composition of property composition and application thereof.
Background technology
Fluxapyroxad (fluxapyroxad), chemical formula: C18H12F5N3O, chemical name: 3-(difluoromethyl)-1-
Methyl-N-(3', 4', 5'-trifluoro-biphenyl-2-base) pyrazole-4-carboxamide.
Fluxapyroxad belongs to benzamide type antibacterial, for succinate dehydrogenase inhibitors, is a kind of broad-spectrum germicide,
There is the treatment of excellence, systemic activity, all kinds of crop banded sclerotial blights, gray mold etc. are respectively provided with good control effect.
Probenazole (thiabendazole), molecular formula: C10H7N3S, chemical name: 2-(4-thiazolyl)-1H-benzo miaow
Azoles.Structural formula:
Probenazole is a kind of efficient, wide-spectrum bactericide, is drawn to push up conductive performance, but can not conduct to base in tool.Holding effect
Phase is long, has cross resistance with benzimidazole germicide.Ascomycetes, basidiomycetes and Fungi Imperfecti there are is inhibitory activity, is used for
Prevent and treat various crop fungal disease and antiseptic preservation of fruits and vegetables.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, along with the change of pattern of farming, melon fruits and vegetables etc.
Industrial crops cultivated area progressively expands, and disease occurrence degree, generation quantity all increase, and in preventing and treating, difficulty strengthens；
On the other hand, the resistance of pathogen rises under lasting medicament selection pressure year by year, and the prevention effect of single dose is had a greatly reduced quality,
Control of plant disease is faced with significant challenge.
Summary of the invention:
It is an object of the invention to provide a kind of applied widely, low cost, effective fluorine-containing azoles for above-mentioned technical problem
Bacterium amide and the plant bactericidal composition of probenazole.
It is a still further object of the present invention to provide this bactericidal composition and cause the application on fungal disease at preventing and treating plant epiphyte,
Especially in the purposes prevented and treated on the fungal diseases such as banded sclerotial blight, gray mold, bakanae disease of rice, pears powdery mildew, anthrax.
It is an object of the invention to be achieved through the following technical solutions:
A kind of Fluxapyroxad-containsterilization and the bactericidal composition of probenazole, this bactericidal composition with fluxapyroxad with probenazole is
Principle active component, wherein fluxapyroxad is 1～70:1～50 with the mass ratio of probenazole, wherein in bactericidal composition
Active ingredient is present in compositions with enhancing effective amount.
Described bactericidal composition, wherein fluxapyroxad is preferably 10～70:1～50 with the mass ratio of probenazole, enters one
Step is preferably 20～70:1～10, the most preferably 20～70:1～4.
Fluxapyroxad with the preferred mass proportioning of probenazole can also be: 70:1,50:1,30:1,20:1,10:
1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30,1:50.
In the compositions of the present invention, the weight/mass percentage composition accounting for compositions both fluxapyroxad and probenazole is 2～80%.
Preferably 5～70%.
Described bactericidal composition, wherein with fluxapyroxad and probenazole for principle active component and known auxiliary agent and tax
Shape agent is re-dubbed on pesticide any one dosage form allowed.Auxiliary agent known to these, excipient have dispersant, diffusant,
Defoamer, wetting agent, disintegrating agent etc., can use calcium dodecyl benzene sulfonate, alkylphenol polyoxyethylene, benzylphenol
Polyoxyethylene ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products, aliphatic amine polyoxyethylene
Ether, fatty acid ethylene oxide addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, nonyl
Phenol polyethenoxy ether, TWEEN Series, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol series, Sulfonates, carboxylate, sulfur
Hydrochlorate, phosphate, phosphite, lignosulfonates, xanthan gum, phenol formaldehyde condensate, ammonium salt, quaternary etc.
In one or more combinations, excipient includes that Ketohexamethylene, dimethylbenzene, various solvent naphtha, water, antifreezing agent are (such as the third two
Alcohol), deionized water etc..Above auxiliary agent, excipient and other adjuvant can be alone or and use.
Described bactericidal composition, its dosage form is cream, wettable powder, suspending agent, aqueous emulsion or water dispersion granule.
The application on preparation preventing and treating fungal diseases of plants medicine of the above-mentioned bactericidal composition.Especially preventing and treating Cereal,
Application in terms of fruit tree, vegetable crop disease has remarkable result.
Above-mentioned application, described fungal diseases of plants is banded sclerotial blight, gray mold, bakanae disease of rice, pears powdery mildew, charcoal
At least one in cellulitis disease.
The feature of bactericidal composition of the present invention:
1, the fluxapyroxad used by the present invention and probenazole, the mechanism of action is different, and mutual mixture will not produce low touching,
Can Synergistic, reduce dosage, reduce cost.
2, the present composition scope of application increases, it is adaptable to preventing and treating Cereal, fruit tree, the refractory fungal disease of vegetable,
Particularly prevent and treat banded sclerotial blight, gray mold, bakanae disease of rice, pears powdery mildew, anthrax etc. and all have significant effect.This
Bright bactericidal composition has good prevention effect to ascomycetes, basidiomycetes, Fungi Imperfecti and Oomycete fungal disease；And press down
Insect processed or the fungus drug-fast generation to unitary agent (fluxapyroxad and probenazole are arbitrary).Sterilization group of the present invention
Compound can produce higher synergistic function, and the consumption of the independent reactive compound of amount ratio of this mixture drops significantly
Low, i.e. the activity of mixture is more than the activity of independent component.
Compared with prior art beneficial effects of the present invention: (1), compared with single dose, said composition antagonism fungal disease is such as
The fungal diseases such as banded sclerotial blight, gray mold, bakanae disease of rice, pears powdery mildew, anthrax have obvious synergistic function, gram
Taking and delayed Drug resistance, expanding prevention is composed, hence it is evident that improve prevention effect；(2) preventing and treating recruitment, drug cost are reduced；
(3) alternative routine and the pesticide being easily generated resistance；(4) compared with single dose, produce and use cost reduces；(5)
The suppression drug-fast generation of fungus, its effect uses apparently higher than its single dose.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of dosage form is conventional method,
" % " of the present invention is mass percent.
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure the different agents EC to bacterial strain50Value, uses co-toxicity coefficient calculating side
Method, calculates the co-toxicity coefficient (CTC) of mixture, determines the building performance of mixture, and circular is as follows:
In mixture, a certain single dose (is generally selected EC as standard agent50Junior), calculate:
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Toxicity index × A the single dose of theoretical toxicity index=A single dose in mixture the toxicity index of proportion+B single dose ×
B single dose proportion in mixture
The EC of actual measurement toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theory toxicity index × 100
When co-toxicity coefficient classification: CTC is more than 120, mixture has synergetic, is antagonism when CTC is less than 80, CTC
It it is summation action between 80-120.
According to effective ingredient fluxapyroxad (A): probenazole (B) quality proportioning is: 80:1,70:1,50:1,
30:1,20:1,10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:
30,1:50,1:60 test, and measure it to pears anthrax bacteria (Colletotrichum gloeosporioides Penz.)
Co-toxicity coefficient.
Table 1: the fluxapyroxad+probenazole different ratio indoor biometrics result to pears anthrax bacteria
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 12.5% fluxapyroxad SC | Y=4.514+1.201X | 2.540 | - |
| 60% probenazole WP | Y=4.247+2.524X | 1.987 | - |
| A:B=80:1 | Y=3.771+3.556X | 2.216 | 114.21 |
| A:B=70:1 | Y=4.552+2.598X | 1.488 | 170.04 |
| A:B=50:1 | Y=4.654+1.874X | 1.529 | 165.23 |
| A:B=30:1 | Y=4.484+2.365X | 1.652 | 152.41 |
| A:B=20:1 | Y=4.624+2.635X | 1.389 | 180.45 |
| A:B=10:1 | Y=4.787+1.209X | 1.499 | 165.23 |
| A:B=5:1 | Y=4.111+3.051X | 1.956 | 124.08 |
| A:B=2.5:1 | Y=4.459+2.350X | 1.699 | 138.49 |
| A:B=1:1 | Y=4.603+2.630X | 1.416 | 157.48 |
| A:B=1:2 | Y=4.806+1.547X | 1.335 | 160.53 |
| A:B=1:4 | Y=4.888+2.635X | 1.103 | 188.29 |
| A:B=1:6 | Y=4.296+4.451X | 1.439 | 142.54 |
| A:B=1:10 | Y=4.630+3.625X | 1.265 | 160.25 |
| A:B=1:20 | Y=4.583+2.045X | 1.600 | 125.48 |
| A:B=1:30 | Y=4.744+1.205X | 1.632 | 122.63 |
| A:B=1:50 | Y=4.783+2.301X | 1.243 | 160.54 |
| A:B=1:60 | Y=4.520+1.447X | 2.148 | 92.82 |
Field control effectiveness test:
The pesticidal preparations preventing and treating pears anthrax test prepared with above-described embodiment.
1, test processes: this test medicine consumption sets three concentration for the treatment of respectively according to the difference of each composition, compares medicine
Agent is pesticide single dose 12.5% fluxapyroxad SC and 60% probenazole WP and blank clean water experiment respectively.
2, each plot area of test method is 66.7m2, it is repeated 3 times；Investigation drug effect after investigating before dispenser and preventing and treating
Method is: randomization 5 point in test treatment region, carries out severity Scaling according to country's field test relevant criterion, meter
Calculate preventive effect.Result of the test is shown in Table 2:
Table 2 field test effect
Being shown by indoor biometrics and field efficacy result, fluxapyroxad and probenazole compositions have the most collaborative increasing
Effect effect, the prevention effect of compositions is excellent, and prevention effect is all better than single dose kind, has application valency in agricultural is applied
Value.
Two kinds of reactive compounds can be processed into any one dosage form of permission, illustrates that two kinds have with specific embodiment below
The preparation that effect composition is processed into, but the preparation that these two kinds of active component can be processed is not limited only to set forth below.
Embodiment 1:15% fluxapyroxad probenazole wettable powder (1:2)
By fluxapyroxad 5g, probenazole 10g, detergent LS (to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g,
Dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out air-flow powder
Broken, preparing effective ingredient mass percent is 15% fluxapyroxad probenazole wettable powder.
Embodiment 2:15% fluxapyroxad probenazole wettable powder (1:4)
By fluxapyroxad 3g, probenazole 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g,
Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is 15% fluxapyroxad thiophene
Bacterium spirit wettable powder.
Embodiment 3:14% fluxapyroxad probenazole wettable powder (1:6)
By fluxapyroxad 2g, probenazole 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g,
Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is 14% fluxapyroxad thiophene
Bacterium spirit wettable powder.
Embodiment 4:20% fluxapyroxad probenazole suspending agent (1:1)
Weigh 10g fluxapyroxad, 10g probenazole, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof,
Xanthan gum 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, at sand milling
Making effective Ingredient percent under the effect of machine is 20% fluxapyroxad probenazole suspending agent.
Embodiment 5:55% fluxapyroxad probenazole aqueous emulsion (1:10)
Weigh 5g fluxapyroxad, 50g probenazole, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g,
Alkylphenol polyoxyethylene 1g, solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely
Putting into the mixing of mixing kettle high speed, making effective Ingredient percent is 55% fluxapyroxad probenazole aqueous emulsion.
Embodiment 6:42% fluxapyroxad probenazole cream (1:20)
Weigh 2g fluxapyroxad, 40g probenazole, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g,
Solvent naphtha is to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective ingredient matter
Amount percentage ratio is 42% fluxapyroxad probenazole cream.
Embodiment 7:70% fluxapyroxad probenazole cream (2.5:1)
Weigh 50g fluxapyroxad, 20g probenazole, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g,
Castor oil polyoxyethylene ether 2g, solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing kettle
Middle mixing, making effective Ingredient percent is 70% fluxapyroxad probenazole cream.
Embodiment 8:18% fluxapyroxad probenazole water dispersion granule (5:1)
Weigh 15g fluxapyroxad, 3g probenazole, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g,
Polyvinyl alcohol 5g, Borax 2g, kieselguhr 28g complement to 100g, are made by water dispersible granular agent method by above raw material
Effective ingredient mass percent is 17% fluxapyroxad probenazole water dispersion granule.
Embodiment 9:11% fluxapyroxad probenazole cream (10:1)
Weigh 10g fluxapyroxad, 1g probenazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g,
Solvent naphtha is to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective ingredient matter
Amount percentage ratio is 11% fluxapyroxad probenazole cream.
Embodiment 10:31.5% fluxapyroxad probenazole microemulsion (20:1)
Weigh 30g fluxapyroxad, 1.5g probenazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphorus
Acid esters 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.By above raw material
The method preparing microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 31.5% fluorine azoles bacterium
Amide probenazole microemulsion.
Embodiment 11:31% fluxapyroxad probenazole cream (30:1)
Weigh 30g fluxapyroxad, 1g probenazole, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g,
Solvent naphtha is to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, makes effective ingredient matter
Amount percentage ratio is 31% fluxapyroxad probenazole cream.
Embodiment 12:51% fluxapyroxad probenazole suspending agent (50:1)
Weigh 50g fluxapyroxad, 1g probenazole, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof,
Xanthan gum 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, at sand milling
Making effective Ingredient percent under the effect of machine is 51% fluxapyroxad probenazole suspending agent.
Embodiment 13:32% fluxapyroxad probenazole microemulsion (1:15)
Weigh 2g fluxapyroxad, 30g probenazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphorus
Acid esters 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.By above raw material
The method preparing microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 32% fluorine azoles bacterium acyl
Amine probenazole microemulsion.
Embodiment 14:6% fluxapyroxad probenazole aqueous emulsion (1:5)
Weigh 1g fluxapyroxad, 5g probenazole, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkane
Base phenol polyethenoxy ether 1g, solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely is thrown
Entering the mixing of mixing kettle high speed, making effective Ingredient percent is 6% fluxapyroxad probenazole aqueous emulsion.
Embodiment 15:62% fluxapyroxad probenazole microemulsion (1:30)
Weigh 2g fluxapyroxad, 60g probenazole, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphorus
Acid esters 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.By above raw material
The method preparing microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 62% fluorine azoles bacterium acyl
Amine probenazole microemulsion.
Embodiment 16:51% fluxapyroxad probenazole suspending agent (1:50)
Weigh 1g fluxapyroxad, 50g probenazole, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof,
Xanthan gum 0.15g, ethylene glycol 5g, silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complement to 100g with water, at sand milling
Making effective Ingredient percent under the effect of machine is 51% fluxapyroxad probenazole suspending agent.
Embodiment 17:7% fluxapyroxad probenazole water dispersion granule (1:2.5)
Weigh 2g fluxapyroxad, 5g probenazole, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g,
Polyvinyl alcohol 5g, Borax 2g, white carbon 3g, kieselguhr complement to 100g, above raw material are pressed water dispersion granule side
It is 7% fluxapyroxad probenazole water dispersion granule that method makes effective ingredient mass percent.
Claims (10)
1. a Fluxapyroxad-containsterilization and the bactericidal composition of probenazole, it is characterised in that this bactericidal composition is with fluorine azoles bacterium
Amide and probenazole are principle active component, and wherein fluxapyroxad is 1～70:1～50 with the mass ratio of probenazole.
Bactericidal composition the most according to claim 1, it is characterised in that described fluxapyroxad and the matter of probenazole
Amount ratio is 10～70:1～50.
Bactericidal composition the most according to claim 2, it is characterised in that described fluxapyroxad and the matter of probenazole
Amount ratio is 20～70:1～10.
Bactericidal composition the most according to claim 3, it is characterised in that described fluxapyroxad and the matter of probenazole
Amount ratio is 20～70:1～4.
Bactericidal composition the most according to claim 1, it is characterised in that described fluxapyroxad and probenazole two
It is 2-80% that person accounts for the weight/mass percentage composition of compositions.
Bactericidal composition the most according to claim 5, it is characterised in that described fluxapyroxad and probenazole two
It is 5-70% that person accounts for the weight/mass percentage composition of compositions.
Bactericidal composition the most according to claim 1, it is characterised in that be main with fluxapyroxad and probenazole
Effective ingredient and insecticides adjuvant, excipient are configured on pesticide any one dosage form allowed.
Bactericidal composition the most according to claim 7, it is characterised in that described dosage form is cream, suspending agent, water
Emulsion, wettable powder or water dispersion granule.
9. the application on preparation preventing and treating fungal diseases of plants medicine of the bactericidal composition described in claim 1.
Application the most according to claim 9, it is characterised in that described fungal diseases of plants is banded sclerotial blight, grey mold
At least one in disease, bakanae disease of rice, pears powdery mildew, anthrax.
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| CN101257798A (en) * | 2005-08-05 | 2008-09-03 | 巴斯福股份公司 | Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides |
| US20080293786A1 (en) * | 2007-05-23 | 2008-11-27 | Korea Institute Of Science And Technology | Novel 2-imino-1,3-thiazoline-based compounds and t-type calcium channel inhibitors containing the same |
| CN102014628A (en) * | 2008-02-05 | 2011-04-13 | 巴斯夫欧洲公司 | Plant health composition |
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| CN101257798A (en) * | 2005-08-05 | 2008-09-03 | 巴斯福股份公司 | Fungicidal mixtures containing substituted 1-methyl pyrazol-4-yl carboxylic acid anilides |
| US20080293786A1 (en) * | 2007-05-23 | 2008-11-27 | Korea Institute Of Science And Technology | Novel 2-imino-1,3-thiazoline-based compounds and t-type calcium channel inhibitors containing the same |
| CN102014628A (en) * | 2008-02-05 | 2011-04-13 | 巴斯夫欧洲公司 | Plant health composition |
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| CN106172431A (en) * | 2016-07-12 | 2016-12-07 | 安徽省农业科学院植物保护与农产品质量安全研究所 | A kind of Fluxapyroxad-containsterilization and the bactericidal composition of probenazole |
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