CN105766927A - Bactericidal composition containing bixafen and phenamacril and application thereof - Google Patents
Bactericidal composition containing bixafen and phenamacril and application thereof Download PDFInfo
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- CN105766927A CN105766927A CN201510993277.3A CN201510993277A CN105766927A CN 105766927 A CN105766927 A CN 105766927A CN 201510993277 A CN201510993277 A CN 201510993277A CN 105766927 A CN105766927 A CN 105766927A
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- Prior art keywords
- cyano
- amino
- bacterium amine
- pyrrole bacterium
- phenylancryic acetate
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- 239000000203 mixture Substances 0.000 title claims abstract description 55
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 32
- 239000005738 Bixafen Substances 0.000 title abstract description 5
- LDLMOOXUCMHBMZ-UHFFFAOYSA-N bixafen Chemical compound FC(F)C1=NN(C)C=C1C(=O)NC1=CC=C(F)C=C1C1=CC=C(Cl)C(Cl)=C1 LDLMOOXUCMHBMZ-UHFFFAOYSA-N 0.000 title abstract description 5
- YKRQBWKLHCEKQH-KHPPLWFESA-N ethyl (z)-3-amino-2-cyano-3-phenylprop-2-enoate Chemical compound CCOC(=O)C(\C#N)=C(/N)C1=CC=CC=C1 YKRQBWKLHCEKQH-KHPPLWFESA-N 0.000 title abstract description 5
- 208000031888 Mycoses Diseases 0.000 claims abstract description 11
- 241000221785 Erysiphales Species 0.000 claims abstract description 6
- 241000918585 Pythium aphanidermatum Species 0.000 claims abstract description 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims abstract description 6
- ZGOAEMCMBVUNMX-UHFFFAOYSA-N 1,1'-biphenyl;1h-pyrrole Chemical compound C=1C=CNC=1.C1=CC=CC=C1C1=CC=CC=C1 ZGOAEMCMBVUNMX-UHFFFAOYSA-N 0.000 claims description 79
- 241000894006 Bacteria Species 0.000 claims description 79
- 150000001412 amines Chemical class 0.000 claims description 79
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 78
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- 239000006071 cream Substances 0.000 claims description 14
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- 238000002360 preparation method Methods 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 239000000575 pesticide Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000002917 insecticide Substances 0.000 claims 1
- 239000004615 ingredient Substances 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 17
- 239000003795 chemical substances by application Substances 0.000 abstract description 9
- 201000010099 disease Diseases 0.000 abstract description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 6
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- 206010059866 Drug resistance Diseases 0.000 abstract description 2
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- 244000052616 bacterial pathogen Species 0.000 abstract 1
- 230000001934 delay Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 25
- 238000002156 mixing Methods 0.000 description 18
- -1 diffusant Substances 0.000 description 15
- 238000000034 method Methods 0.000 description 14
- 239000002994 raw material Substances 0.000 description 11
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 239000004530 micro-emulsion Substances 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 8
- 230000002265 prevention Effects 0.000 description 7
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- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
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- 206010039509 Scab Diseases 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 description 4
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 4
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- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 238000005303 weighing Methods 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 3
- 241000233866 Fungi Species 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 229920005610 lignin Polymers 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 3
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
- 239000004576 sand Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- UTNFXXOYUNRYBI-SCSAIBSYSA-N (2r)-2-amino-2-cyanopropanoic acid Chemical class N#C[C@](N)(C)C(O)=O UTNFXXOYUNRYBI-SCSAIBSYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 241000235349 Ascomycota Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 244000241235 Citrullus lanatus Species 0.000 description 1
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 240000008790 Musa x paradisiaca Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 241000845082 Panama Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000000205 computational method Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical group O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 150000003217 pyrazoles Chemical group 0.000 description 1
- 230000007115 recruitment Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000004763 spore germination Effects 0.000 description 1
- 150000003871 sulfonates Chemical class 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a bactericidal composition containing bixafen and phenamacril and an application thereof. The bactericidal composition takes the bixafen and the phenamacril as main effective ingredients, wherein the mass ratio of the bixafen to the phenamacril is (1-70):(1-50). The bactericidal composition can be applied in preventing and curing cereal, fruit tree and vegetable diseases, can be used for preventing and curing powdery mildew, rust disease, damping off, glume blight, gibberellic disease, blight and other fungal diseases, has a relatively high synergistic effect, overcomes and delays the drug resistance of pathogenic bacteria, and is high in bactericidal speed and long in lasting period; the application cost is reduced, and the preventing and curing effects are obviously superior to those of a single agent.
Description
Technical field
The present invention relates to a kind of bactericidal composition and application thereof, especially a kind of with biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate be main active bactericidal composition and application.
Background technology
Biphenyl pyrrole bacterium amine (Bixafen), chemical formula: C18H12Cl2F3N3O, chemical name: N-(3 ', 4 '-two chloro-5-fluorine hexichol-2-base)-3-(difluoromethyl)-1-methylpyrazole-4-Methanamide.Structural formula:
Biphenyl pyrrole bacterium amine is pyrazoles antibacterial, is the systemic fungicide that has concurrently of a kind of novel wide spectrum, protection and therapeutic activity.
2-cyano-3-amino-3-phenylancryic acetate (phenamacril), molecular formula: C12H12N2O2Chemical name: 2-cyano group-3-amino-3-ethyl phenylacrylate; belong to 2-cyanoalanine series bactericidal agent; there is poison efficient, micro-, broad spectrum, low residue, environment amenable advantage; have protection and therapeutical effect concurrently; can effectively suppress the growth of Fusarium spp. mycelia; affect conidia germination speed; and germ tube is lopsided after making spore germination; mycelium can not be split into, to disease specially good effects such as the microbial wheat scab of reaping hook, cotton wilt, banana Panama disease, bakanae disease of rice, watermelon blights.
The industrial crops cultivated areas such as the difficulty of prevention and cure of current phytopathogen is increasing, on the one hand, along with the change of pattern of farming, melon fruits and vegetables progressively expand, and disease occurrence degree, occur quantity all to increase, and in preventing and treating, difficulty strengthens；On the other hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the prevention effect of single dose is had a greatly reduced quality, and control of plant disease is faced with significant challenge.
Summary of the invention
It is an object of the invention to provide a kind of applied widely, plant bactericidal composition containing biphenyl pyrrole bacterium amine Yu 2-cyano-3-amino-3-phenylancryic acetate that cost is low, effective for above-mentioned technical problem.
It is a still further object of the present invention to provide this bactericidal composition and cause the application on fungal disease at preventing and treating plant epiphyte, particularly in the purposes prevented and treated on the fungal diseases such as powdery mildew, rust, damping-off, glume blight, head blight, droop.
It is an object of the invention to be achieved through the following technical solutions:
A kind of bactericidal composition containing biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate, this bactericidal composition is with biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate for principle active component, wherein biphenyl pyrrole bacterium amine is 1～70:1～50 with the mass ratio of 2-cyano-3-amino-3-phenylancryic acetate, and wherein in bactericidal composition, active ingredient is present in compositions with enhancing effective amount.
Described bactericidal composition, wherein biphenyl pyrrole bacterium amine is preferably 10～70:1～50 with the mass ratio of 2-cyano-3-amino-3-phenylancryic acetate, more preferably 10～30:1～20, is further preferably 10～20:1～10.
The preferred mass ratio of biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate can also be 70:1,50:1,30:1,20:1,10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30,1:50.
In the compositions of the present invention, the weight/mass percentage composition accounting for compositions both biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate is 2～80%.Preferably 5～70%.
Described bactericidal composition, any one dosage form being wherein re-dubbed on pesticide with biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate for principle active component and known auxiliary agent and excipient to allow.These known auxiliary agents, excipient has dispersant, diffusant, defoamer, wetting agent, disintegrating agent etc., calcium dodecyl benzene sulfonate can be adopted, alkylphenol polyoxyethylene, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether and similar products thereof, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, NPE, TWEEN Series, fatty alcohol-polyoxyethylene ether, Polyethylene Glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphite, lignosulfonates, xanthan gum, phenol formaldehyde condensate, ammonium salt, one or more combinations in quaternary etc., excipient includes Ketohexamethylene, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as propylene glycol), deionized water etc..Above auxiliary agent, excipient and other adjuvant can be alone or and use.
Described bactericidal composition, its dosage form is cream, wettable powder, suspending agent, aqueous emulsion or water dispersion granule.
The application on preparation preventing and treating fungal diseases of plants medicine of the above-mentioned bactericidal composition.Particularly in preventing and treating Cereal, fruit tree, vegetable crop disease aspect application there is remarkable result.
Above-mentioned application, described fungal diseases of plants is at least one in powdery mildew, rust, damping-off, glume blight, head blight, droop.
The feature of bactericidal composition of the present invention:
1, biphenyl pyrrole bacterium amine used by the present invention and 2-cyano-3-amino-3-phenylancryic acetate, mutual mixture will not produce to conflict, can Synergistic, reduce dosage, reduce cost.
2, the present composition scope of application increases, it is adaptable to preventing and treating the refractory fungal disease of Cereal, fruit tree, vegetable, particularly preventing and treating powdery mildew, rust, damping-off, glume blight, head blight, droop etc. all has significant effect.Ascomycetes, basidiomycetes, Fungi Imperfecti and Oomycete fungal disease are had good prevention effect by bactericidal composition of the present invention；And suppress the drug-fast generation to unitary agent (biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate are arbitrary) of insect or fungus or antibacterial.Bactericidal composition of the present invention can produce higher synergistic function, and the consumption of the independent reactive compound of amount ratio of this mixture is substantially reduced, and namely the activity of mixture is more than the activity of independent component.
Compared with prior art beneficial effects of the present invention: (1) is compared with single dose, the said composition antagonism fungal disease such as fungal disease such as powdery mildew, rust, damping-off, glume blight, head blight, droop has obvious synergistic function, overcome and delayed Drug resistance, expanding prevention is composed, hence it is evident that improve prevention effect；(2) preventing and treating recruitment, drug cost are reduced；(3) alternative routine and the pesticide being easily generated resistance；(4) compared with single dose, produce and use cost reduces；(5) suppressing the drug-fast generation of fungus, its effect uses apparently higher than its single dose.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described, and in embodiment, the preparation method of dosage form is conventional method, and " % " of the present invention is mass percent.
Indoor biometrics is tested:
In indoor employing mycelial growth rate method, measure the different agents EC to bacterial strain50Value, adopts co-toxicity coefficient computational methods, calculates the co-toxicity coefficient (CTC) of mixture, it is determined that mixture building performance, and circular is as follows:
In mixture, a certain single dose (is generally selected EC for standard agent50Junior), it is calculated:
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
Toxicity index × A single dose the toxicity index of proportion+B single dose × B single dose proportion in mixture in mixture of theoretical toxicity index=A single dose
The EC of actual measurement toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theory toxicity index × 100
When co-toxicity coefficient classification: CTC is more than 120, mixture has synergetic, is antagonism when CTC is less than 80, and CTC is summation action between 80-120.
According to effective ingredient biphenyl pyrrole bacterium amine (A): 2-cyano-3-amino-3-phenylancryic acetate (B) quality proportioning is: 80:1,70:1,50:1,30:1,20:1,10:1,5:1,2.5:1,1:1,1:2,1:4,1:6,1:10,1:20,1:30,1:50,1:60,1:70 test, and measures its co-toxicity coefficient to wheat scab (FusaHumgraminearumSehw.).
Table 1: biphenyl pyrrole bacterium amine+2-cyano-3-amino-3-phenylancryic acetate different ratio indoor biometrics result to wheat scab
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 10% biphenyl pyrrole bacterium amine WP | Y=3.787+1.202X | 10.210 | - |
| 25% 2-cyano-3-amino-3-phenylancryic acetate SC | Y=0.923+3.632X | 13.263 | - |
| A:B=80:1 | Y=2.848+2.098X | 10.606 | 115.86 |
| A:B=70:1 | Y=2.853+2.365X | 8.084 | 152.06 |
| A:B=50:1 | Y=1.205+4.023X | 8.779 | 140.15 |
| A:B=30:1 | Y=3.195+1.885X | 9.067 | 135.98 |
| A:B=20:1 | Y=3.691+1.520X | 7.266 | 170.12 |
| A:B=10:1 | Y=1.576+3.621X | 8.823 | 141.14 |
| A:B=5:1 | Y=0.571+4.587X | 9.236 | 136.59 |
| A:B=2.5:1 | Y=0.145+5.200X | 8.585 | 150.02 |
| A:B=1:1 | Y=1.555+3.542X | 9.390 | 142.52 |
| A:B=1:2 | Y=2.714+2.301X | 9.853 | 140.09 |
| A:B=1:4 | Y=3.875+1.205X | 8.588 | 164.87 |
| A:B=1:6 | Y=2.221+2.658X | 11.102 | 128.96 |
| A:B=1:10 | Y=2.878+2.332X | 8.124 | 178.05 |
| A:B=1:20 | Y=1.529+3.259X | 11.613 | 125.63 |
| A:B=1:30 | Y=2.957+2.052X | 9.898 | 147.84 |
| A:B=1:50 | Y=1.006+4.151X | 9.166 | 160.05 |
| A:B=1:60 | Y=1.933+2.651X | 14.350 | 102.30 |
| A:B=1:70 | Y=2.629+2.000X | 15.323 | 95.85 |
Field control effectiveness test:
The pesticidal preparations prepared with above-described embodiment prevents and treats wheat scab test.
1, test processes: this test medicine consumption sets three concentration for the treatment of respectively according to the difference of each composition, and comparison medicament is pesticide single dose 10% biphenyl pyrrole bacterium amine WP and 25% 2-cyano-3-amino-3-phenylancryic acetate SC and blank clean water experiment respectively.
2, each plot area of test method is 66.7m2, repeat 3 times；Investigation drug effect method after investigating before dispenser and preventing and treating is: in test treatment region, (every takes 5m to randomization 5 point2), carry out severity Scaling according to country's field test relevant criterion, calculate preventive effect.Result of the test is in Table 2:
Table 2 field test effect
By indoor biometrics and field efficacy it is shown that biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate compositions have obvious synergistic function, the prevention effect of compositions is excellent, and prevention effect is all better than single dose kind, has using value in agricultural is applied.
Two kinds of reactive compounds can be processed into any one dosage form of permission, with specific embodiment, the preparation that two kinds of effective ingredient are processed into is described below, but the preparation that these two kinds of active component can be processed is not limited only to set forth below.
Embodiment 1:15% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate wettable powder (1:2)
By biphenyl pyrrole bacterium amine 5g, 2-cyano-3-amino-3-phenylancryic acetate 10g, detergent LS (to methoxyl group fatty acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is 15% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate wettable powder.
Embodiment 2:15% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate wettable powder (1:4)
By biphenyl pyrrole bacterium amine 3g, 2-cyano-3-amino-3-phenylancryic acetate 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is 15% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate wettable powder.
Embodiment 3:14% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate wettable powder (1:6)
By biphenyl pyrrole bacterium amine 2g, 2-cyano-3-amino-3-phenylancryic acetate 12g, sodium lauryl sulphate 3g, dispersing agent NNO 4g, white carbon 5g, Kaolin adds to 100g mixture and carries out comminution by gas stream, and preparing effective ingredient mass percent is 14% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate wettable powder.
Embodiment 4:20% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent (1:1)
Weigh 10g biphenyl pyrrole bacterium amine, 10g 2-cyano-3-amino-3-phenylancryic acetate, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, xanthan gum 0.15g, ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complementing to 100g with water, making effective Ingredient percent under the effect of sand mill is 20% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent.
Embodiment 5:55% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate aqueous emulsion (1:10)
Weigh 5g biphenyl pyrrole bacterium amine, 50g 2-cyano-3-amino-3-phenylancryic acetate, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, 150# solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into the mixing of mixing kettle high speed, and making effective Ingredient percent is 55% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate aqueous emulsion.
Embodiment 6:42% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream (1:20)
Weighing 2g biphenyl pyrrole bacterium amine, 40g 2-cyano-3-amino-3-phenylancryic acetate, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, 150# solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 42% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream.
Embodiment 7:70% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream (2.5:1)
Weighing 50g biphenyl pyrrole bacterium amine, 20g 2-cyano-3-amino-3-phenylancryic acetate, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor oil polyoxyethylene ether 2g, 150# solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 70% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream.
Embodiment 8:18% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate water dispersion granule (5:1)
Weigh 15g biphenyl pyrrole bacterium amine, 3g 2-cyano-3-amino-3-phenylancryic acetate, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, Borax 2g, kieselguhr complements to 100g, and by water dispersible granular agent method, above raw material is formed with effect Ingredient percent is 17% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate water dispersion granule.
Embodiment 9:11% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream (10:1)
Weighing 10g biphenyl pyrrole bacterium amine, 1g 2-cyano-3-amino-3-phenylancryic acetate, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, 150# solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 11% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream.
Embodiment 10:31.5% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate microemulsion (20:1)
Weigh 30g biphenyl pyrrole bacterium amine, 1.5g 2-cyano-3-amino-3-phenylancryic acetate, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.The method that above raw material is prepared microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 32% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate microemulsion.
Embodiment 11:31% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream (30:1)
Weighing 30g biphenyl pyrrole bacterium amine, 1g 2-cyano-3-amino-3-phenylancryic acetate, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, 150# solvent naphtha are to 100g.The method that above raw material is prepared cream routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 31% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate cream.
Embodiment 12:51% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent (50:1)
Weigh 50g biphenyl pyrrole bacterium amine, 1g 2-cyano-3-amino-3-phenylancryic acetate, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, xanthan gum 0.15g, ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complementing to 100g with water, making effective Ingredient percent under the effect of sand mill is 51% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent.
Embodiment 13:32% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate microemulsion (1:15)
Weigh 2g biphenyl pyrrole bacterium amine, 30g 2-cyano-3-amino-3-phenylancryic acetate, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.The method that above raw material is prepared microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 32% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate microemulsion.
Embodiment 14:6% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate aqueous emulsion (1:5)
Weigh 1g biphenyl pyrrole bacterium amine, 5g 2-cyano-3-amino-3-phenylancryic acetate, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, 150# solvent naphtha 13g, add water to 100g.The method that above raw material is prepared aqueous emulsion routinely puts into the mixing of mixing kettle high speed, and making effective Ingredient percent is 6% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate aqueous emulsion.
Embodiment 15:62% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate microemulsion (1:30)
Weigh 2g biphenyl pyrrole bacterium amine, 60g 2-cyano-3-amino-3-phenylancryic acetate, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkylphenol polyoxyethylene 1g, isopropanol 10g, add water to 100g.The method that above raw material is prepared microemulsion routinely puts into mixing in mixing kettle, and making effective Ingredient percent is 62% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate microemulsion.
Embodiment 16:51% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent (1:50)
Weigh 1g biphenyl pyrrole bacterium amine, 50g 2-cyano-3-amino-3-phenylancryic acetate, lignin 2g, polyoxyethylene poly-oxygen propylene aether and sulfate 4g thereof, xanthan gum 0.15g, ethylene glycol 5g, siloxanes 0.10g, aluminium-magnesium silicate 0.5g, complementing to 100g with water, making effective Ingredient percent under the effect of sand mill is 51% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent.
Embodiment 17:7% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate water dispersion granule (1:2.5)
Weigh 2g biphenyl pyrrole bacterium amine, 5g 2-cyano-3-amino-3-phenylancryic acetate, wooden sodium sulfonate 8g, sodium lauryl sulphate 2g, ammonium sulfate 5g, polyvinyl alcohol 5g, Borax 2g, white carbon 3g, kieselguhr complement to 100g, and by water dispersible granular agent method, above raw material is formed with effect Ingredient percent is 7% biphenyl pyrrole bacterium amine 2-cyano-3-amino-3-phenylancryic acetate water dispersion granule.
Claims (10)
1. the bactericidal composition containing biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate, it is characterised in that this bactericidal composition is with biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate for principle active component, and wherein biphenyl pyrrole bacterium amine is 1～70:1～50 with the mass ratio of 2-cyano-3-amino-3-phenylancryic acetate.
2. bactericidal composition according to claim 1, it is characterised in that the mass ratio of described biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate is 10～70:1～50.
3. bactericidal composition according to claim 2, it is characterised in that the mass ratio of described biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate is 1～30:1～20.
4. bactericidal composition according to claim 2, it is characterised in that the mass ratio of described biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate is 10～20:1～10.
5. bactericidal composition according to claim 1, it is characterised in that it is 2-80% that both described biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate account for the weight/mass percentage composition of compositions.
6. bactericidal composition according to claim 5, it is characterised in that it is 5-70% that both described biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate account for the weight/mass percentage composition of compositions.
7. bactericidal composition according to claim 1, it is characterised in that any one dosage form being configured on pesticide with biphenyl pyrrole bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate for principle active component and insecticides adjuvant, excipient to allow.
8. bactericidal composition according to claim 7, it is characterised in that described dosage form is cream, suspending agent, aqueous emulsion, wettable powder or water dispersion granule.
9. the application on preparation preventing and treating fungal diseases of plants medicine of the bactericidal composition described in claim 1.
10. application according to claim 9, it is characterised in that described fungal diseases of plants is at least one in powdery mildew, rust, damping-off, glume blight, head blight, droop.
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| CN110573014A (en) * | 2017-04-27 | 2019-12-13 | Upl有限公司 | Fungicidal combinations |
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| CN102318627A (en) * | 2011-06-26 | 2012-01-18 | 青岛奥迪斯生物科技有限公司 | A kind of innovative efficient bactericidal composite |
| CN102771502A (en) * | 2012-07-30 | 2012-11-14 | 陕西上格之路生物科学有限公司 | Sterilizing composition containing js399-19 and amide fungicide |
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| CN102771502A (en) * | 2012-07-30 | 2012-11-14 | 陕西上格之路生物科学有限公司 | Sterilizing composition containing js399-19 and amide fungicide |
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| CN110573014A (en) * | 2017-04-27 | 2019-12-13 | Upl有限公司 | Fungicidal combinations |
| CN110573014B (en) * | 2017-04-27 | 2022-02-11 | Upl有限公司 | Fungicidal combinations |
| AU2018260402B2 (en) * | 2017-04-27 | 2023-05-25 | Upl Ltd | Fungicidal combinations |
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