CN106266239A - Improve compositions of memory and its preparation method and application - Google Patents

Abstract

The invention relates to a composition for improving memory, a preparation method and application thereof, and belongs to the technical field of medicine. The active ingredients of the composition are prepared from the following medicinal materials in parts by weight: 2-6 parts of schisandra, 3-9 parts of ginseng, 1-3 parts of panax notoginseng, and 6-12 parts of wolfberry. In the prescription, aiming at the etiology and pathogenesis of senile dementia, nourishing kidney and nourishing essence, invigorating qi and dispelling blood stasis are used as the treatment method, Schisandra chinensis is used as the monarch drug to replenish qi and restrain yin, and nourishing kidney essence, and ginseng and Panax notoginseng are used to nourish qi and improve intelligence. , promoting blood circulation and dissipating blood stasis are used as ministerial medicines, and Chinese wolfberry is used as an adjuvant medicine to nourish kidney and essence, and support righteousness, to promote the recovery of memory and cognitive impairment of the elderly, and to provide a basis for the development of traditional Chinese medicine and health food for improving memory.

Description

Composition for improving memory, its preparation method and application

technical field

The invention relates to the technical fields of medicine and food, in particular to a memory-improving composition and its preparation method and application.

Background technique

Memory loss, traditional Chinese medicine called forgetfulness, forgetfulness, happy forgetfulness. The disease is more common in the elderly clinically, so it is often called senile dementia. Traditional Chinese medicine believes that Alzheimer's disease belongs to the category of "dementia" in traditional Chinese medicine. It is said in "Su Wen Wu Zang Cheng Sheng Pian": "All the marrow belongs to the brain", "Lingshu Hai Lun" says: "The brain It is the sea of marrow, its infusion lies in its lid, and its infusion lies in Fengfu." "Introduction to Medicine" says: "The brain is the sea of marrow. All the marrow belongs to the brain, so it goes up to the brain and down to the tail sacrum. The way of ascending and descending", the above discussion all show that the brain is the place where the marrow gathers. It can be seen from this that whether the brain is full or not will directly affect the use of the brain to govern the gods. The memory of the human brain must also be based on the brain as the material basis and source. Only when the marrow is sufficient and the brain is nourished can normal learning and memory be developed. thinking functions. The fullness of the brain is related to the internal organs, but especially the kidneys. The kidney is the foundation of congenital nature, the foundation of sealing and storing, storing the essence to produce marrow and then leading to the brain, just as the "Lingshu Meridians" says: "People are born, first become essence, and after essence is formed, the brain marrow grows." In the Qing Dynasty, Tang Rongchuan Its "Medical Classics Essence" also said that "the reason why things are not forgotten depends on this memory. Where they are remembered, it is in the kidney essence. The kidney produces essence, which turns into marrow and stores it in the brain." It can be seen that the kidney Essence is the main source of material to nourish the brain, when the essence is full, the marrow will be full, and if the essence is deficient, the marrow will be empty. Therefore, in clinical practice, tonifying the kidney and replenishing the essence should be the basic treatment method. At the same time, the elderly often have symptoms of qi and blood stasis due to qi deficiency, which hinders the nourishment of the kidney essence to the marrow sea.

Contents of the invention

Based on this, the object of the present invention is to provide a memory-improving composition, which is aimed at the characteristics of the elderly and has a better memory-improving effect.

A composition for improving memory, the active ingredient of which is prepared from the following medicinal materials in parts by weight:

2-6 parts of schisandra, 3-9 parts of ginseng, 1-3 parts of Panax notoginseng, 6-12 parts of wolfberry.

According to the theory of traditional Chinese medicine and combined with modern medicine, the present invention selects schisandra chinensis, ginseng, notoginseng and medlar for compatibility. In the formula:

Schisandra chinensis, sour in taste, sweet in taste, warm in nature, returns to lung, heart and kidney channels. It has the effects of astringent and astringent, nourishing qi and promoting body fluid, invigorating the kidney and calming the heart. For chronic cough and shortness of breath, nocturnal spermatorrhea, enuresis, frequent urination, chronic diarrhea, spontaneous sweating, night sweats, thirsty wounds, shortness of breath, internal heat and thirst, palpitations, insomnia, etc. The main components of Schisandra are lignans and polysaccharides. Modern pharmacological studies have shown that Schisandra has obvious effects of lowering fat, protecting liver, calming nerves and anti-oxidation. Schisandra chinensis is reused as the monarch drug in this prescription, aiming to exert its effects of nourishing qi, restraining yin and nourishing kidney essence.

Ginseng, sweet in taste, slightly bitter, neutral in nature, slightly warm, returns to the spleen, lung, and heart channels. The effect is to invigorate vital energy, invigorate the spleen and lungs, promote body fluid and quench thirst, soothe the nerves and improve the mind, and tonify all deficiencies. The main components of ginseng are ginsenosides, polysaccharides and volatile oils. Notoginseng, sweet in taste, slightly bitter, warm in nature, returns to liver and stomach meridian. It has the effects of dispelling blood stasis and stopping bleeding, reducing swelling and relieving pain, and is mainly used to treat epistaxis, blood in the stool, metrorrhagia, hemoptysis, hematemesis, traumatic bleeding, chest and abdomen tingling and other diseases. Modern pharmaceutical research has confirmed that notoginseng mainly includes saponins and flavonoids, which can improve myocardial blood supply and dilate coronary arteries. In addition, sitosterol and carotin in notoginseng also have the effect of lowering blood lipids. In the prescription, ginseng and Panax notoginseng are used as ministerial drugs. While assisting the monarch drug Schisandra to exert the effect of nourishing qi and strengthening the root, it also plays the role of calming the nerves, improving intelligence and filling the emptiness of the sea of marrow.

Fructus Lycium barbarum, sweet in taste, flat in nature; returns liver, kidney, lung meridian. It has the effects of invigorating the kidney and essence, nourishing the liver and improving eyesight, moistening the lungs and promoting body fluid. It is used for consumptive essence deficiency, soreness of waist and knees, dizziness and tinnitus, internal heat and thirst, blood deficiency and chlorosis, and blurred vision. The main components of Lycium barbarum are Lycium barbarum polysaccharides, betaine, carotenoids and carotenoid esters, and various vitamins and amino acids. According to a large number of literature reports, Lycium barbarum can improve immunity, regulate nervous system function, protect liver, lower blood pressure, lower blood fat, Hypoglycemic and anti-aging effects. This prescription uses Lycium barbarum as an adjuvant drug to invigorate the kidneys and essence, support righteousness, and play the role of delaying aging and enhancing memory ability by improving the body's immune ability.

Accordingly, the present invention reuses Schisandra chinensis as the monarch drug, aiming to bring into play its effect of replenishing qi and restraining yin and nourishing kidney essence; taking ginseng and Radix Notoginseng as ministerial drugs, while assisting the monarch drug Schisandra chinensis to exert the effect of nourishing qi and consolidating the root, It plays the role of calming the nerves and improving the mind and filling the emptiness of the sea of marrow; and the fruit of wolfberry is used as an adjuvant to nourish the kidney and essence, nourish the righteousness, and play the role of delaying aging and enhancing memory by improving the body's immunity.

In one of the embodiments, the active ingredients of the composition are prepared from the following medicinal materials in parts by weight:

6 parts of schisandra, 9 parts of ginseng, 1 part of Panax notoginseng, 6 parts of wolfberry.

This Faming also discloses the preparation method of the above memory-improving composition, comprising the following steps:

Extraction of Schisandra chinensis: Weigh Schisandra chinensis in parts by weight, add ethanol aqueous solution with a volume percentage of 60%-90%, extract at 50-80°C, filter, and concentrate the filtrate to obtain Schisandra chinensis liquid extract;

Ginseng extraction: Weigh ginseng by weight, add ethanol aqueous solution with a volume percentage of 60%-100%, extract at 70-100°C, filter, and concentrate the filtrate to obtain ginseng liquid extract;

Radix Notoginseng Extraction: Weigh Radix Notoginseng by weight, add an aqueous ethanol solution with a volume percentage of 30%-70%, extract at 50-90°C, filter, and concentrate the filtrate to obtain a liquid extract of Notoginseng;

Lycium barbarum extraction: Weigh wolfberry by weight, add ethanol aqueous solution with a volume percentage of 0%-30%, extract at 80-100°C, filter, and concentrate the filtrate to obtain wolfberry liquid extract;

Mixing: Take the above-mentioned schisandra liquid extract, ginseng liquid extract, notoginseng liquid extract and wolfberry liquid extract, mix evenly, and obtain.

The above preparation method extracts the active ingredients in the medicinal materials, which improves the convenience for patients to take, and the preparation method has a simple process and is easy to carry out industrial production.

In one of the embodiments, in the extraction of Schisandra chinensis, take Schisandra chinensis by weight, add 10-18ml of ethanol aqueous solution with a volume percentage of 70%-80% per gram of Schisandra chinensis, and extract at 60-70°C for 1-3hr , filtered, and the filtrate was concentrated to obtain Schisandra extract.

In one of the embodiments, in the extraction of ginseng, ginseng is weighed in parts by weight, 7-13ml of ethanol aqueous solution with a volume percentage of 75%-85% is added per gram of ginseng, and 1-3 times, 1-3hr each time, filter, combine and concentrate the filtrates to obtain ginseng fluid extract.

In the extraction of Panax notoginseng in one of the examples, weigh Panax notoginseng by weight, add 6-10ml of ethanol aqueous solution with a volume percentage of 45%-55% per gram of Panax notoginseng, and extract at 65-75°C for 1 -3 times, 1-3hr each time, filter, combine and concentrate the filtrates to obtain a notoginseng liquid extract.

In the wolfberry extraction described in one of the examples, take wolfberry by weight, add 7-13ml of water per gram of wolfberry, extract 1-3 times at 90-100°C, 1-3hr each time, filter, and combine the filtrates Concentrate to get wolfberry liquid extract.

The invention also discloses the application of the above-mentioned composition in the preparation of pharmaceutical preparations or health care preparations with memory-improving effects.

In one of the embodiments, the pharmaceutical preparation is oral liquid, hard capsule, soft capsule, tablet, pill, dropping pill, granule, powder, honey paste or dew.

In one of the embodiments, the health product preparation is tea in bag or liquor.

Compared with the prior art, the present invention has the following beneficial effects:

The memory-improving composition of the present invention is aimed at the etiology and pathogenesis of senile dementia. Radix Notoginseng nourishes qi and improves intelligence, promotes blood circulation and dissipates blood stasis, and Chinese wolfberry fruit nourishes kidney and essence, and nourishes righteousness as an adjuvant drug to promote the recovery of memory and cognitive impairment in the elderly.

Based on the theory of traditional Chinese medicine, the anti-fatigue composition screened the functional components and designed the formula through the mouse dark avoidance experiment and the water maze experiment, and finally obtained the traditional Chinese medicine formula that can clearly improve memory. and health food.

Moreover, after mixing each raw material in a specific ratio, it has a very good effect. After 30 days of oral administration of the composition, the water maze test is carried out, and the time for the mice to find the platform is significantly different from that of the model group.

detailed description

The present invention is explained in detail below in conjunction with specific examples, but does not impose any limitation on the present invention.

The bulk drugs and adjuvants used in the following examples are all commercially available.

Example 1

A composition for improving memory, prepared from the following medicinal materials:

Schisandra 6g, ginseng 9g, Sanqi 1g, wolfberry 6g.

The above raw materials are prepared according to the following steps:

Extraction of Schisandra: Weigh Schisandra by weight, add 14 ml of 75% ethanol aqueous solution per gram of Schisandra, extract in a water bath at 65°C for 2 hours, filter, and concentrate the filtrate to obtain Schisandra liquid extract.

Ginseng extraction: Weigh ginseng by weight, add 10ml of 80% ethanol aqueous solution per gram of ginseng, extract in 85°C water bath twice, 1hr each time, filter, combine the filtrates and concentrate to obtain ginseng liquid extract .

Panax notoginseng extraction: take panax notoginseng by weight, add 8ml of ethanol aqueous solution with a volume percentage of 50% per gram of panax notoginseng, extract 2 times in a water bath at 70°C, each time for 2hr, filter, and concentrate after combining the filtrates to obtain Sanqi Qiliu extract.

Lycium barbarum extraction: Weigh wolfberry by weight, add 10ml of water per gram of wolfberry, extract 3 times at 100°C, 3 hours each time, filter, combine filtrates and concentrate to obtain wolfberry liquid extract.

Mixing: take the above-mentioned schisandra liquid extract, ginseng liquid extract, notoginseng liquid extract and wolfberry liquid extract, mix evenly, and dry to obtain composition A for improving memory.

Example 2

A composition for improving memory, prepared from the following medicinal materials:

Schisandra 2g, ginseng 9g, Sanqi 3g, wolfberry 12g.

Prepared according to the method of Example 1, the composition B for improving memory was obtained.

Comparative example 1

This comparative example prepares a composition, which is basically the same as the memory-improving composition of Example 1, except that the composition of this comparative example is prepared from the following medicinal materials:

Schisandra 6g, ginseng 9g, Sanqi 1g.

Composition C was prepared with reference to the method of Example 1.

Comparative example 2

This comparative example prepares a composition, which is basically the same as the memory-improving composition of Example 1, except that the composition of this comparative example is prepared from the following medicinal materials:

Schisandra 6g, Panax notoginseng 1g, wolfberry 6g.

Composition D was prepared according to the method of Example 1.

Comparative example 3

This comparative example prepares a composition, which is basically the same as the memory-improving composition of Example 1, except that the composition of this comparative example is prepared from the following medicinal materials:

9 g ginseng, 1 g Panax notoginseng, 6 g wolfberry.

Composition E was prepared with reference to the method of Example 1.

Comparative example 4

This comparative example prepares a composition, which is basically the same as the memory-improving composition of Example 1, except that the composition of this comparative example is prepared from the following medicinal materials:

Schisandra 6g, ginseng 9g, wolfberry 6g.

Composition F was prepared according to the method of Example 1.

Comparative example 5

This comparative example prepares a composition, which is basically the same as the memory-improving composition of Example 1, except that the composition of this comparative example is prepared from the following medicinal materials:

Schisandra 6g, ginseng 9g, Sanqi 1g, wolfberry 6g, Yizhiren 6g.

Composition G was prepared according to the method of Example 1.

Experimental example 1

Get the composition that above-mentioned embodiment and comparative example prepare, carry out mouse dark avoidance test, method is as follows:

1. Experimental animals.

Healthy ICR male mice, weighing 20±2g, were provided by the Experimental Animal Research Center of Jilin University with the license number SCXK-(Ji)2015-0005. Drinking water freely, ingesting food reasonably, and starting the experiment after 7 days of adaptation to the environment.

2. Experimental method.

The ICR mice were randomly divided into blank control group (distilled water administered by intragastric administration), composition A group, composition B group, composition C group, composition D group, composition E group, composition F group, composition G group, the mice were continuously orally administered for 30 days, and the dosage was 0.1ml/10g (the concentration of the composition was 0.366g/ml).

On the 29th day, after gavage for 30 minutes, the dark avoidance experiment was carried out. That is to say, put the mouse into the dark room with its face facing away from the hole in the dark avoidance instrument, and start the timer at the same time. The time recorded by the timer when the mouse entered the hole and arrived at the dark room was the incubation period. In this experiment, the mice were trained for 5 minutes, and the number of mistakes made by the mice within 5 minutes was recorded. The second test was carried out 30 minutes after administration on the next day. The incubation period of each mouse and the number of errors that occurred within 5 min were recorded.

3. Experimental results.

The experimental results are shown in the table below.

Table 1. The results of the dark avoidance test for mice in each group ( , n=15)

Note: Compared with normal group, *P<0.05.

The above results show that the number of errors in the dark avoidance test of the mice after continuous intragastric administration for 30 days was significantly reduced compared with the blank control mice.

Moreover, in the composition of the present invention, the lack of each medicinal material will have a certain impact on the memory-improving effect of this product, so the four traditional Chinese medicinal materials are indispensable, and the effect of adding one medicinal material is not as good as these four traditional Chinese medicines. Material compatibility. Compared with Example 2, adopting the optimal proportion of Example 1 has the best effect of improving memory.

Experimental example 2

Get the composition A prepared in the above-mentioned Example 1, and carry out the mouse dark avoidance test, the method is as follows:

1. Experimental animals.

Healthy ICR male mice, weighing 20±2g, were provided by the Experimental Animal Research Center of Jilin University with the license number SCXK-(Ji)2015-0005. Drinking water freely, ingesting food reasonably, and starting the experiment after 7 days of adaptation to the environment.

2. Experimental method.

The ICR mice were randomly divided into blank control group (distilled water by intragastric administration), model group (distilled water administered by intragastric administration, scopolamine 5 mg/kg intraperitoneal injection), low-dose composition A group, medium-dose composition A group, composition A In the high-dose group, the mice in each group were administered by intragastric administration at a volume of 0.1ml/10g for 30 days, once a day. (The low, medium and high doses of composition A are formulated at concentrations of 0.183 g/ml, 0.366 g/ml and 0.732 g/ml, respectively).

On the 29th day and the 30th day of gavage, the dark avoidance test was carried out. On the 29th day, the training was started, and 30 minutes before the training, intragastric administration was carried out. After 20 minutes of intragastric administration, the mice in the blank control group were injected with normal saline intraperitoneally, and the mice in the model group and other groups were injected with 5 mg/kg hydrobromic acid intraperitoneally. Scopolamine. After 10 minutes of intraperitoneal injection, put the mouse into the dark room with the face back to the hole in the dark avoidance instrument, and start the timer at the same time. The time recorded by the timer when the mouse entered the hole and arrived at the dark room was the incubation period. In this experiment, the mice were trained for 5 minutes, and the number of mistakes made by the mice within 5 minutes was recorded. The second test was carried out on the 30th day of intragastric administration, and the administration method was the same as that on the 29th day. Record the incubation period of each mouse and the number of errors that occurred within 5 minutes.

3. Experimental results.

The experimental results are shown in the table below.

Table 2. The results of the dark avoidance test for mice in each group ( , n=15)

Note: Compared with the blank group, **P<0.01; compared with the model group, #P<0.05, ##P<0.01; compared with the middle dose group, ▲P<0.05, ▲▲P<0.01.

The above results showed that compared with the blank group, the incubation period of the mice in the model group was significantly shortened (P<0.01), and the number of mistakes was significantly increased (P<0.01), indicating that the modeling was successful; compared with the model group, the incubation period of the mice in the middle and high dose groups Significantly prolonged (P<0.05, P<0.01), the number of errors was significantly reduced (P<0.05, P<0.01); and with the increase of the dosage, the latency period was gradually extended (low-dose group and high-dose group were respectively compared with middle-dose group comparison, P<0.05, P<0.01), and the number of errors gradually decreased (low-dose group and high-dose group were compared with middle-dose group, P<0.05). Experimental results show that the composition has the effect of improving memory, and the effect is dose-dependent.

Experimental example 3

Get the composition that above-mentioned embodiment and comparative example prepare, carry out mouse Morris water maze experiment, method is as follows:

1. Experimental animals.

Healthy ICR male mice, weighing 20±2g, were provided by the Experimental Animal Research Center of Jilin University with the license number SCXK-(Ji)2015-0005. Drinking water freely, ingesting food reasonably, and starting the experiment after 7 days of adaptation to the environment.

2. Experimental method.

The ICR mice were randomly divided into blank control group (distilled water was given by intragastric administration), model group (distilled water was given by intragastric administration, and 5 mg/kg scopolamine was injected intraperitoneally), composition A group, composition B group, composition C group, and composition D group, composition E group, composition F group, and composition G group, the mice in each group were administered intragastrically at a volume of 0.1 ml/10 g for 30 days, once a day. The dosage is 0.1ml/10g (the concentration of the composition is 0.366g/ml).

On the 25th day of intragastric administration, the water maze test was carried out, and the intragastric administration was carried out 30 minutes before the training. After 20 minutes of intragastric administration, the mice in the blank control group were intraperitoneally injected with normal saline, and the mice in the model group, composition A group, Composition B group, composition C group, composition D group, composition E group, composition F group, composition G group received intraperitoneal injection of scopolamine 5 mg/kg. After 10 minutes of intraperitoneal injection, the mice were placed in the Morris water maze video tracking test system WMT-100, and the training time of the mice was set to 120s, and the mice that did not reach the end point within 120s were recorded as 120s. Before the first experiment, mice were placed near the platform and allowed to climb up 3 times automatically. Before each training, the mice were placed near the platform and allowed to climb up to the platform once. Train every 24 hours, continue to administer medicine during training, and the administration method is the same as that on the 25th day. Collect the experimental data on the 29th day of administration. On the 30th day of administration, the platform was removed to count the spatial search ability of the mice, and the administration method was the same as that on the 25th day. And record the experimental results of the number of times the mice crossed the platform.

2. Experimental results.

The experimental results are shown in the table below.

Table 3 Water maze positioning navigation and exploration results of mice in each group ( , n=15)

Note: Compared with blank group, **P<0.01; compared with model group, #P<0.05, ##P<0.01.

The above results show that, compared with the model group, the time to find the platform of the compositions A and B prepared in Examples 1 and 2 is significantly shortened; and the times of passing the platform are significantly increased.

Moreover, in the composition of the present invention, the lack of each medicinal material will have a certain impact on the memory-improving effect of this product, so the four traditional Chinese medicinal materials are indispensable, and the effect of adding one medicinal material is not as good as these four traditional Chinese medicines. Material compatibility. Compared with Example 2, adopting the optimal proportion of Example 1 has the best effect of improving memory.

The technical features of the above-mentioned embodiments can be combined arbitrarily. To make the description concise, all possible combinations of the technical features in the above-mentioned embodiments are not described. However, as long as there is no contradiction in the combination of these technical features, should be considered as within the scope of this specification.

The above-mentioned embodiments only express several implementation modes of the present invention, and the descriptions thereof are relatively specific and detailed, but should not be construed as limiting the patent scope of the invention. It should be pointed out that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

Claims (10)

1. A composition for improving memory, characterized in that, the active ingredient of said composition is prepared from the medicinal materials of the following parts by weight: 2-6 parts of schisandra, 3-9 parts of ginseng, 1-3 parts of Panax notoginseng, 6-12 parts of wolfberry. 2. The composition for improving memory according to claim 2, wherein the active ingredient of the composition is prepared from the following medicinal materials in parts by weight: 6 parts of schisandra, 9 parts of ginseng, 1 part of Panax notoginseng, 6 parts of wolfberry. 3. The preparation method of the composition improving memory described in any one of claims 1-2, is characterized in that, comprises the following steps: Extraction of Schisandra chinensis: Weigh Schisandra chinensis in parts by weight, add ethanol aqueous solution with a volume percentage of 60%-90%, extract at 50-80°C, filter, and concentrate the filtrate to obtain Schisandra chinensis liquid extract; Ginseng extraction: Weigh ginseng by weight, add ethanol aqueous solution with a volume percentage of 60%-100%, extract at 70-100°C, filter, and concentrate the filtrate to obtain ginseng liquid extract; Radix Notoginseng Extraction: Weigh Radix Notoginseng by weight, add an aqueous ethanol solution with a volume percentage of 30%-70%, extract at 50-90°C, filter, and concentrate the filtrate to obtain a liquid extract of Notoginseng; Lycium barbarum extraction: Weigh wolfberry by weight, add ethanol aqueous solution with a volume percentage of 0%-30%, extract at 80-100°C, filter, and concentrate the filtrate to obtain wolfberry liquid extract; Mixing: Take the above-mentioned schisandra liquid extract, ginseng liquid extract, notoginseng liquid extract and wolfberry liquid extract, mix evenly, and obtain. 4. The preparation method of the composition for improving memory according to claim 3, characterized in that, in the extraction of Schisandra chinensis, take Schisandra chinensis by weight, add 10-18ml volume percentage of 70%- 80% ethanol aqueous solution, extract at 60-70°C for 1-3hr, filter, and concentrate the filtrate to obtain Schisandra fluid extract. 5. The preparation method of the memory-improving composition according to claim 3, characterized in that, in the extraction of ginseng, ginseng is weighed in parts by weight, and 7-13 ml of ginseng is added per gram of ginseng, and the volume percentage is 75%- 85% ethanol aqueous solution, 80-90 ° C extraction 1-3 times, each time 1-3hr, filter, combine the filtrates and concentrate to obtain ginseng liquid extract. 6. The preparation method of the composition for improving memory according to claim 3, characterized in that, in the extraction of Radix Notoginseng, weigh Radix Notoginseng in parts by weight, add 6-10ml volume percentage of Radix Notoginseng by every gram of Radix Notoginseng 45%-55% ethanol aqueous solution, extract 1-3 times at 65-75°C, each time for 1-3hr, filter, combine the filtrates and concentrate to obtain the notoginseng liquid extract. 7. The preparation method of the composition for improving memory according to claim 3, characterized in that, in the extraction of wolfberry, take wolfberry by weight, add 7-13ml of water per gram of wolfberry, and extract 1 -3 times, 1-3hr each time, filter, combine and concentrate the filtrates to obtain the liquid extract of Lycium barbarum. 8. The application of the composition according to any one of claims 1-2 in the preparation of pharmaceutical preparations or health care preparations with memory-improving effects. 9. application according to claim 8, described pharmaceutical preparation is oral liquid, hard capsule, soft capsule, tablet, pill, dropping pill, granule, powder, honey paste or dew. 10. The application according to claim 8, the health product preparation is tea in bag or liquor.