CN102302569B - Chinese medicinal composition for promoting lead discharging effect - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition capable of promoting lead excretion. The technical scheme adopted is: the following raw materials are prepared according to the weight ratio : 5-20 parts of Radix Paeoniae Rubra, 10-30 parts of Rosa Roxburghii root, 10-30 parts of Pittosporum bark, 10-20 parts of woody fragrance, pumpkin seeds 10-30 servings. In the present invention, Radix Paeoniae Rubra and Pittodia bark play the role of clearing away heat; pumpkin seeds and roxburghii root play the role of invigorating the spleen and diuresis; The purpose is to prevent lead from harming the human body and improve symptoms, and has no toxic and side effects. It is suitable for long-term use by people with high blood lead. In the present invention, each raw material is easy to obtain, the production cost is low, and because pure natural Chinese medicinal materials are used, the toxic and side effects of the product are small. Through practice, the traditional Chinese medicine composition of the present invention has obvious reducing effects on blood lead, bone lead, liver lead and brain lead.

Description

A kind of traditional Chinese medicine composition with effect of promoting lead excretion

technical field

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition with the function of promoting lead excretion.

Background technique

With the acceleration of urbanization and industrialization, environmental lead pollution is becoming more and more serious, even affecting human health. Lead in the environment can enter the human body through the respiratory tract and skin, and is distributed throughout the body in the form of lead hydrogen phosphate, of which 90-95% is converted into orthophosphate and deposited in bones, teeth, internal organs, skin, and hair, and then slowly Transferred into the blood (the ideal concentration of lead in the blood is zero), causing harm to various tissue systems of the human body, among which the nervous system and the hematopoietic system are the most sensitive to lead.

Lead is a non-essential element for the human body. It has a strong affinity for body tissues, and by affecting the essential elements of the human body, it disturbs the balance of the physiological combination and proportional relationship of the essential elements in the human body, thereby disturbing the enzyme system in the body and the biomacro. The physiological activity of the molecule will cause the enzyme system in the body to lose its normal physiological activity and other regulation functions that regulate the balance of body functions will be disordered, thereby affecting multiple systems of the human body. The specific manifestations are: affecting the development of intelligence and bone development, causing indigestion and endocrine disorders, leading to anemia, high blood pressure and arrhythmia, and destroying kidney function and immune function. In addition, lead also has carcinogenic effects.

According to the international diagnostic standard for lead poisoning in children (blood lead value>100ug/L), the prevalence rate of lead poisoning in urban children in my country is between 30% and 40%, and the industrial pollution area in some cities is nearly 100%. In urban areas, 10%-30% of children's blood lead exceeds the standard. The potential harm of lead to health has attracted people's attention day by day.

At present, the basic principle of prevention and treatment of lead poisoning is the combination of environmental intervention, health education and clinical treatment. Environmental intervention is fundamental, health education is the basic means, and drug treatment is only considered for moderate and above lead poisoning. The drugs for the clinical treatment of lead poisoning mainly include disodium calcium edetate (CaNa2EDTA), sodium dimercaptosuccinate (DMSA), etc. Although these drugs can reduce the lead load in the body and have a good lead-expelling effect, they will make the human body The loss of essential trace elements will also cause damage to the kidneys, and the side effects are relatively large, and lead-dispelling drugs have little significance in reversing the nerve damage caused by lead. Therefore, except for moderate to severe lead poisoning, drugs are generally not used in clinical practice.

Contents of the invention

In order to solve the above problems, the present invention provides a traditional Chinese medicine composition for promoting lead removal with low cost, good effect of lead removal and less toxic and side effects.

The technical scheme adopted in the present invention is: a kind of traditional Chinese medicine composition that has the effect of promoting lead discharge, is made from the following raw materials in proportion by weight :

Paeoniae Rubra 5-20 parts

10-30 servings of prickly pear root

10-30 copies of pituitary bark

Woody fragrance 10-20 parts

10-30 servings of pumpkin seeds.

The present invention uses the above-mentioned traditional Chinese medicine composition as an active ingredient, and can be prepared into oral preparations according to conventional techniques, such as water decoction, oral liquid, capsules, tablets and the like.

The preferred preparation method is as follows:

1) According to the above weight ratio, weigh each raw material for later use;

2) Add 8-10 times the total weight of each raw material, soak in water for 2-3 hours, heat and decoct, and filter the decoction; add 8-10 times the amount of water to the medicinal residues, heat the decoction, filter the decoction, and combine the filtrates to obtain supernatant;

3) When the supernatant is concentrated to a relative density of 1.05-1.06, it enters the spray dryer, the inlet air temperature is controlled at 130-140°C, the outlet air temperature is 100-110°C, and the feed rate is 3-6 ml/min to obtain a spray dry powder.

The spray-dried powder is further prepared into oral liquid, capsule, tablet or granule etc. according to a conventional process.

The beneficial effect of the present invention is: Radix Paeoniae Rubra, bitter, be slightly cold, return Liver Meridian, effect is heat-clearing and cooling blood, dissipating blood stasis and relieving pain; Rosa roxburghii root is sweet, sour, astringent, invigorates the spleen and stomach, stops diarrhea; Flat, returns to liver, kidney meridian, clears away heat and relieves pain; woody fragrance, sweet, pungent, promotes qi and relieves pain; pumpkin seed, sweet, flat in nature, returns to large intestine meridian, has the effect of diuresis and detumescence. The above-mentioned combination of traditional Chinese medicines has played the effects of clearing away heat and invigorating the stomach, promoting qi circulation and relieving pain.

In the present invention, Radix Paeoniae Rubra and Pittodia bark play a role in clearing heat; pumpkin seeds and roxburghii root play a role in invigorating the spleen and diuresis; The purpose is to prevent lead from harming the human body and improve symptoms, and has no toxic and side effects. It is suitable for long-term use by people with high blood lead. In the present invention, each raw material is easy to obtain, the production cost is low, and because pure natural Chinese medicinal materials are used, the toxic and side effects of the product are small. Through practice, the traditional Chinese medicine composition of the present invention has obvious reducing effects on blood lead, bone lead, liver lead and brain lead.

Detailed ways

Embodiment 1 has the Chinese medicine composition that promotes the effect of excreting lead

(1) The weight ratio of raw materials is as follows:

Radix Paeoniae Alba 50g

Prickly pear root 100g

Pittosporum peel 100g

Woody Fragrance 100g

100g pumpkin seeds

(2) The preparation method is as follows:

1) Take the raw material medicine according to the above weight ratio;

2) Add red peony root, Rosa roxburghii root, Pittosporum peel, wood incense and pumpkin seeds, soak in water for 2 hours, heat and decoct, and filter after boiling; add 8 times the amount of water to the dregs, heat to boil, and boil After filtering, the filtrates were combined to obtain a supernatant, which was a water decoction.

Embodiment 2 has the Chinese medicine composition that promotes the effect of excreting lead

(1) The weight ratio of raw materials is as follows

Radix Paeoniae Alba 200g

Prickly pear root 300g

Pittosporum peel 300g

Woody Fragrance 200g

300g pumpkin seeds

(2) The preparation method is as follows:

1) Take the raw material medicine according to the above weight ratio;

2) Add Radix Paeoniae Rubra, Rosa Rosa Root, Pittosporum Peel, Woody Fragrance and Pumpkin Seeds, soak in 10 times the total weight of water for 2 hours, heat and decoct, and filter after boiling; add 8 times the amount of water to the dregs and heat until boiling, then boil After filtering, the filtrates were combined to obtain the supernatant;

3) When the supernatant is concentrated to a relative density of 1.05, it enters the spray dryer, the inlet air temperature is controlled at 130°C, the outlet air temperature is 110°C, and the feed rate is 5ml/min to obtain 40g of spray-dried powder.

The spray-dried powder can be made into oral preparations, such as oral liquids, capsules, tablets or granules, etc. according to conventional techniques.

Embodiment 3 has the Chinese medicine composition that promotes the effect of excreting lead

(1) The weight ratio of raw materials is as follows

Radix Paeoniae Alba 120g

Prickly pear root 200g

Pittosporum peel 200g

Woody 150g

200g pumpkin seeds

(2) The preparation method is as follows:

1) Take the raw material medicine according to the above weight ratio;

2) Add Radix Paeoniae Rubra, Rosa Rosa Root, Pittosporum Peel, Woody Fragrance and Pumpkin Seeds, soak in 8 times the total weight of water for 2 hours, heat and decoct, filter after boiling; add 8 times the amount of water to the dregs, heat to boil, and boil After filtering, the filtrates were combined to obtain the supernatant;

3) When the supernatant is concentrated to a relative density of 1.06, it enters the spray dryer, the inlet air temperature is controlled at 140°C, the outlet air temperature is 100°C, and the feed rate is 5ml/min to obtain 25g of spray-dried powder.

The spray-dried powder can be made into oral preparations, such as oral liquids, capsules, tablets or granules, etc. according to conventional techniques.

Experimental example 1:

Select 60 healthy Kunming mice, clean animals, half male and half female, body weight 20 ± 2 grams, divided into 5 groups, namely blank control group, lead-exposed model group, high, medium and low Chinese medicine composition water decoction 3 dose groups, 12 rats in each group, dissolved lead acetate in distilled water and injected intraperitoneally at 40 mg/kg to establish a lead-exposed mouse model.

The decoction of the traditional Chinese medicine composition is prepared by a conventional decoction method, and concentrated to the corresponding concentration. The different dosage groups of the decoction include a high-dose group (40g/kg), a middle-dose group (20g/kg), and a low-dose group (10g/kg). kg), each drug group was administered by intragastric administration, and the other groups were administered with the same amount of normal saline, and the experiment continued for 8 weeks. After the administration, take 40ul of blood from the right femoral vein of the mouse, put it into a covered plastic centrifuge tube filled with 0.36ml of 1% nitric acid, and shake well; take 50% of the femur on one side, weigh it and digest it, add dilute nitric acid to make it to 5ml According to the same method, the liver and brain tissue were taken accordingly, and the blood, bone, and liver lead content were measured with an atomic spectrophotometer; the statistics of the above data were tested by T.

±s，n=12）  Table 1 Chinese medicine composition water decoction of the present invention is to mouse blood lead, bone lead, liver and brain lead (mg/kg) content influence (

±s, n=12)

* represents P <0.01 compared with the model group control, Δ represents P <0.01 compared with the blank group control

The water decoction of the traditional Chinese medicine composition has a significant effect on the blood lead content, and there is a significant difference between each dose group and the model group, P <0.05; P <0.05; the traditional Chinese medicine composition had a significant effect on the liver lead content, and there was a significant difference between the low, middle and high dose group and the model group, P <0.05; There was a significant difference between groups, P <0.05.

Claims (4)

1. one kind has the Chinese medicine composition that promotes lead-eliminating effect, it is characterized in that being made by following raw material medicaments in part by weight proportioning :

Radix Paeoniae Rubra 5-20 part

Radix Rosae Normalis 10-30 part

Cortex erythrinae 10-30 part

Radix Aucklandiae 10-20 part

Semen Cucurbitae 10-30 part.

2. the preparation method with the Chinese medicine composition that promotes lead-eliminating effect claimed in claim 1 is characterized in that comprising the steps:

1) by weight portion proportioning claimed in claim 1, it is for subsequent use to take by weighing each crude drug;

2) add 8-10 times of water gaging of each crude drug gross weight and soaked 2-3 hour, heating decocts, and decoction liquor is filtered; Medicinal residues add 8-10 times of water gaging heating again, and decoction liquor is filtered, and filtrate merges, and gets supernatant.

3. according to the preparation method with the Chinese medicine composition that promotes lead-eliminating effect claimed in claim 2, characterized by further comprising following steps

When 3) supernatant concentration to relative density is 1.05-1.06, advance spray dryer, 130-140 ℃ of inlet temperature control, leaving air temp 100-110 ℃, charging rate is 3-6ml/ minute, gets spray drying powder.

4. the application of Chinese medicine composition claimed in claim 1 in the conventional oral formulations of preparation.