CN106265423A - Having relieves inflammation or internal heat disappear pain effect oral care composition - Google Patents
Having relieves inflammation or internal heat disappear pain effect oral care composition Download PDFInfo
- Publication number
- CN106265423A CN106265423A CN201610707791.0A CN201610707791A CN106265423A CN 106265423 A CN106265423 A CN 106265423A CN 201610707791 A CN201610707791 A CN 201610707791A CN 106265423 A CN106265423 A CN 106265423A
- Authority
- CN
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- Prior art keywords
- care composition
- sodium
- internal heat
- oral care
- inflammation
- Prior art date
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Links
- 239000000203 mixture Substances 0.000 title claims abstract description 53
- 206010061218 Inflammation Diseases 0.000 title claims abstract description 51
- 230000004054 inflammatory process Effects 0.000 title claims abstract description 51
- 230000036407 pain Effects 0.000 title claims abstract description 48
- 208000002193 Pain Diseases 0.000 title claims abstract description 45
- 230000000694 effects Effects 0.000 title claims abstract description 33
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 38
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- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 claims description 20
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- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims description 16
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 description 2
- 240000000111 Saccharum officinarum Species 0.000 description 2
- 235000007201 Saccharum officinarum Nutrition 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229960004365 benzoic acid Drugs 0.000 description 2
- 229910052796 boron Inorganic materials 0.000 description 2
- 208000002925 dental caries Diseases 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 210000002200 mouth mucosa Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 230000008439 repair process Effects 0.000 description 2
- IBUIVNCCBFLEJL-UHFFFAOYSA-M sodium;phosphoric acid;chloride Chemical compound [Na+].[Cl-].OP(O)(O)=O IBUIVNCCBFLEJL-UHFFFAOYSA-M 0.000 description 2
- 235000000346 sugar Nutrition 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 240000001624 Espostoa lanata Species 0.000 description 1
- 235000009161 Espostoa lanata Nutrition 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 244000147568 Laurus nobilis Species 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- SUZRRICLUFMAQD-UHFFFAOYSA-N N-Methyltaurine Chemical compound CNCCS(O)(=O)=O SUZRRICLUFMAQD-UHFFFAOYSA-N 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 201000004328 Pulpitis Diseases 0.000 description 1
- 206010037464 Pulpitis dental Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000005864 Sulphur Substances 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 244000274883 Urtica dioica Species 0.000 description 1
- 235000009108 Urtica dioica Nutrition 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 229910021538 borax Inorganic materials 0.000 description 1
- 208000020670 canker sore Diseases 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229940091249 fluoride supplement Drugs 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229950008882 polysorbate Drugs 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- BFDWBSRJQZPEEB-UHFFFAOYSA-L sodium fluorophosphate Chemical compound [Na+].[Na+].[O-]P([O-])(F)=O BFDWBSRJQZPEEB-UHFFFAOYSA-L 0.000 description 1
- 239000004328 sodium tetraborate Substances 0.000 description 1
- 235000010339 sodium tetraborate Nutrition 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
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- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/413—Gall bladder; Bile
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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Abstract
The invention discloses a kind of have relieve inflammation or internal heat disappear pain effect oral care composition; described have relieve inflammation or internal heat disappear pain effect oral care composition by percentage to the quality, the raw material including following components be prepared from: Calculus Bovis 0.01%～1%, Radix Scutellariae extract 0.1%～5%, Flos Lonicerae extract 0.1%～5%, Rhizoma Cimicifugae extract 0.1%～5%, Borneolum Syntheticum 0.01%～0.5%, sodium sulfonate 0.1%～5%, nicotiamide 0.1%～5%, surplus are base material.The crowd that oral care composition of the present invention is got angry for easy oral cavity, had a toothache, and have gingivitis, the crowd of periodontitis symptom, pass through compounded technology, making oral care composition of the present invention in addition to having the function of cleaning oral cavity, fresh breath, having relieves inflammation or internal heat simultaneously disappears bitterly, relax the effects such as toothache, gingival hemorrhage.
Description
Technical field
The present invention relates to oral care product technical field, particularly relate to a kind of have relieve inflammation or internal heat disappear pain effect oral cavity protect
Reason compositions.
Background technology
Toothache is a kind of common oral disease, and its Symptoms is root of the tooth pain, red swelling of gingiva, often has stimulation battle array
Bitterly, buccal swelling etc..The reason causing toothache has dental caries, periodontitis, pulpitis, gingivitis mainly due to tooth itself
Deng, the symptom of pain occurs under the influence of internal and external factor.People once have toothache symptom, can bring the biggest to daily life
Painful and inconvenient.The method of preventing and treating toothache, except daily attention oral cavity cleaning health, is eaten beyond light food more, is adhered to every day making
Brush teeth with the Chinese medicinal toothpaste with analgesic activity, be also a kind of simple and the method for practicality.
In modern society, people's rhythm of life is fast, operating pressure big, generally there is the problems such as toothache, oral ulcer, greatly
Have impact on people's orthobiosis, be therefore badly in need of a kind of during routine use just can heat clearing away and internal heat reducing, the toothpaste of reducing swelling and alleviating pain,
Use as common oral care product.
Product for toothache problem is a lot of in the market, and the active component of interpolation is the most different, as added Flos Caryophylli and boron
The fourth boron toothpaste of sand, its analgesia convergence excellent effect, but Borax has certain toxicity；As added the toothpaste of fluoride for dental caries
The dental pain that tooth causes；The sensitive pain that antiallergic sense toothpaste causes for injury of teeth；But use Chinese medicine ingredients to relieve inflammation or internal heat
The toothpaste of the pain that disappears is few.
Summary of the invention
Based on this, it is necessary to for the problems referred to above, it is provided that a kind of have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat.On
State compositions and with the addition of Calculus Bovis, Borneolum Syntheticum, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, the pain that disappears of substantially relieving inflammation or internal heat, slow
Solve the symptoms such as toothache, gingival swelling and pain, canker sore pain.
Concrete technical scheme is as follows:
A kind of have relieve inflammation or internal heat disappear pain effect oral care composition, by percentage to the quality, described in have relieve inflammation or internal heat disappear pain
The oral care composition of effect is prepared from by the raw material including following components:
Calculus Bovis 0.01%～1%, Radix Scutellariae extract 0.1%～5%, Flos Lonicerae extract 0.1%～5%, Rhizoma Cimicifugae extract
Thing 0.1%～5%, Borneolum Syntheticum 0.01%～0.5%, sodium sulfonate 0.1%～5%, nicotiamide 0.1%～5%, surplus are base
Material.
Above-mentioned base material has different selections according to type difference those skilled in the art of prepared oral care composition,
When preparing toothpaste, base material include grinding agent, wetting agent, binding agent, surfactant, essence, sweeting agent, functional additive,
Pigment, preservative and water；
When preparing collutory, base material includes wetting agent, emulsifying agent, essence, sweeting agent, antibacterial, pH adjusting agent, effect
Additive, pigment, preservative and water；
When preparing mouthspray, base material includes wetting agent, emulsifying agent, flavoring agent, ethanol, essence, functional additive, color
Element, preservative and water.
Wherein in some embodiments, described Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, Borneolum Syntheticum,
Sodium sulfonate, the interpolation total amount of nicotiamide have, described in accounting for, the 1～10% of the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat.
Wherein in some embodiments, by percentage to the quality, having described in relieves inflammation or internal heat disappear pain effect mouth care combination
Thing is prepared from by the raw material including following components:
Calculus Bovis 0.03%～0.1%, Radix Scutellariae extract 0.5%～2.0%, Flos Lonicerae extract 0.5%～2.5%, liter
Nettle extract 0.5%～2%, Borneolum Syntheticum 0.03%～0.1%, sodium sulfonate 0.5%～2.0%, nicotiamide 0.5%～2.0%,
Surplus is base material；
Described Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, Borneolum Syntheticum, sodium sulfonate, the adding of nicotiamide
Add total amount account for described in have relieve inflammation or internal heat disappear pain effect oral care composition 3～7%.
Wherein in some embodiments, described oral care composition is toothpaste, collutory, mouthspray.
Wherein in some embodiments, described oral care composition is toothpaste, by percentage to the quality, and described base material bag
Include the raw material of following components, the mass percent of following raw materials according be account for described in have relieve inflammation or internal heat disappear pain effect oral care composition
Mass percent:
Grinding agent 10%～45%, wetting agent 10%～60%, binding agent 0.2%～3%, surfactant 0.5%～
4%, more than essence 0.5%～3%, sweeting agent 0.1%～1%, functional additive 0～3%, pigment trace, preservative trace, water
Amount, described in have the disappear mass percent summation of all raw materials of oral care composition of pain effect of relieving inflammation or internal heat be 100%.
Wherein in some embodiments, described grinding agent is selected from hydrated silica, calcium carbonate, calcium hydrogen phosphate, microcrystalline Cellulose
In at least one；
At least one in sorbitol, glycerol, Polyethylene Glycol, propylene glycol, xylitol of described wetting agent；
At least one in sodium carboxymethyl cellulose, carrageenan, xanthan gum, guar gum of described binding agent；
Described surfactant is selected from sodium lauryl sulfate, sodium lauroyl sarcosine, sodium cocoyl methyl sodium taurocholate
Or at least one in cocamido propyl betaine；Or
Described surfactant is: have selected from sodium lauryl sulfate, sodium lauroyl sarcosine, sodium cocoyl methyl cattle sulphur
At least one in acid sodium or cocamido propyl betaine, also has selected from tween, polyoxyethylene and polyoxypropylene block copolymers
At least one in thing, castor oil hydrogenated polyoxyethylene ether；
At least one in saccharin sodium, sucralose, stevioside, aspartame of described sweeting agent；
Described functional additive selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or
Bisabolol, paeonol, eugenol, glycyrrhizic acid dipotassium.
Above-mentioned prepare raw material that base material used by toothpaste includes more preferably: hydrated silica 15%～30%, wetting agent
10%～60%, sodium carboxymethyl cellulose 0.2%～1%, xanthan gum be 0.2%～1%, surfactant 0.5%～3%,
Essence 0.5%～2.0%, sweeting agent 0.1%～0.6%, functional additive 0～3%.
Wherein in some embodiments, described oral care composition is collutory, by percentage to the quality, and described base material
Including the raw material of following components, the mass percent of following raw materials according be account for described in have relieving inflammation or internal heat disappear pain effect mouth care combination
The mass percent of thing:
Wetting agent 5.0%～30.0%, emulsifying agent 1.0%～10.0%, essence 0.1%～1.0%, sweeting agent 0.05%
～1.0%, antibacterial 0.01～1.0%, pH adjusting agent 0～3.0%, functional additive 0～3.0%, pigment trace, preservative
Trace, water surplus, described in there is the disappear mass percent summation of all raw materials of oral care composition of pain effect of relieving inflammation or internal heat be
100%.
Wherein in some embodiments, described wetting agent is in sorbitol, glycerol, Polyethylene Glycol, propylene glycol, xylitol
At least one；
Described emulsifying agent is selected from tween, polyoxyethylene and polyoxypropylene block copolymers, castor oil hydrogenated polyoxyethylene ether
At least one in, or
Described emulsifying agent is: have selected from tween, polyoxyethylene and polyoxypropylene block copolymers, castor oil hydrogenated polyoxy second
At least one in alkene ether, also has selected from sodium lauryl sulfate, sodium lauroyl sarcosine, sodium cocoyl methyl taurine
At least one in sodium or cocamido propyl betaine；
At least one in saccharin sodium, sucralose, stevioside, aspartame of described sweeting agent；
Described antibacterial is selected from cetylpyridinium chloride or chlorhexidine；
Described pH adjusting agent is selected from disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, sodium pyrophosphate, malic acid
At least one in sodium；
Described functional additive selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or
Bisabolol, paeonol, eugenol, glycyrrhizic acid dipotassium.
Wherein in some embodiments, described oral care composition is mouthspray, by percentage to the quality, and described base
Material include the raw material of following components, the mass percent of following raw materials according be account for described in there is the mouth care group of pain effect of disappearing of relieving inflammation or internal heat
The mass percent of compound:
Wetting agent 5%～40.0%, emulsifying agent 1%～10.0%, flavoring agent 0.1～3.0%, ethanol 0～20.0%, fragrant
Essence 0.1%～2.0%, functional additive 0～3.0%, pigment trace, preservative trace, water surplus, described in there is the pain that disappears of relieving inflammation or internal heat
The mass percent summation of all raw materials of the oral care composition of effect is 100%.
Wherein in some embodiments, described wetting agent is in sorbitol, glycerol, Polyethylene Glycol, propylene glycol, xylitol
At least one；
Described emulsifying agent is selected from tween, polyoxyethylene and polyoxypropylene block copolymers, castor oil hydrogenated polyoxyethylene ether
In at least one；
Described flavoring agent is selected from menthol, Borneolum Syntheticum, menthyl lactate, saccharin sodium, sucralose, stevioside at least
A kind of；
Described functional additive selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or
Bisabolol, paeonol, eugenol, glycyrrhizic acid dipotassium.
Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract are used by the present invention with Borneolum Syntheticum, Rhizoma Cimicifugae extract compatibility, Qi Zhongniu
Huang, Radix Scutellariae extract, Flos Lonicerae extract are mainly heat clearing away and internal heat reducing, asthenic fire in removing body；Rhizoma Cimicifugae extract has yang invigorating, sends out
Table, alleviates headache cold and heat, laryngalgia, effect of aphtha；Borneolum Syntheticum has sterilization, pharynx-clearing throat-benefiting effect；Sodium sulfonate has reparation mouth
Chamber mucosa effect；Nicotiamide has powerful oxidation resistance, with Borneolum Syntheticum, sodium sulfonate jointly rise reducing swelling and alleviating pain, repair viscous
The effect of film.All medicines share, can heat reliving and toxin-eliminating, reducing swelling and alleviating pain, reparation oral environment, thus alleviate toothache, gingival swelling and pain, tooth
The symptom such as gingivitis, oral ulcer.
Advantages of the present invention and providing the benefit that:
1, Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract are carried out compounding work with Borneolum Syntheticum, Rhizoma Cimicifugae extract by the present invention first
The pain that disappears for relieving inflammation or internal heat functional component adds oral care composition to, and these Chinese medicine ingredients complement each other, and reach to relieve inflammation or internal heat the pain that disappears jointly
Purpose, be simultaneously introduced sodium sulfonate and nicotiamide, bactericidal antiphlogistic, repair oral mucosa, improve Stomatocyte metabolism, slow
Solve the pain that red swelling of gingiva, oral ulcer etc. cause；
2, it is remarkably reinforced by analgesic experiment and its alleviation toothache of clinical trial certificate, reparation oral ulcer effect.
3, the oral care composition of the present invention have alleviate oral cavity get angry, have a toothache, effect of oral ulcer, and take effect
Hurry up, have no side effect, be both suitable for occur oral cavity get angry, symptom of having a toothache time use, also be adapted in daily life prevention use.
Detailed description of the invention
Raw materials used in the present invention it is commercially available mill run.
Below by way of concrete preferred embodiment, the present invention is expressed in further detail, but the present invention is not limited in following
Embodiment.In following examples, involved percentage ratio except as otherwise noted, is all calculated in weight percent.
Embodiment 1
A kind of have the toothpaste bitterly acted on that disappears that relieves inflammation or internal heat, and by percentage to the quality, the raw material of following components is prepared from: cattle
Yellow 0.1%, Radix Scutellariae extract 1.5%, Flos Lonicerae extract 1.0%, Rhizoma Cimicifugae extract 2.0%, Borneolum Syntheticum 0.03%, sodium sulfonate
1.0%, nicotiamide 1.0%, hydrated silica 25.0%, sorbitol 40.0%, glycerol 5.0%, sodium carboxymethyl cellulose 0.5%,
Xanthan gum 0.3%, sodium lauryl sulfate 1.6%, cocamido propyl betaine 0.5%, essence 1.2%, saccharin sodium
0.2%, paeonol 0.1%, glycyrrhizic acid dipotassium 0.1%, pigment trace (meeting national quality requirement standard), preservative are micro-
Amount (meeting national quality requirement standard), surplus are water.
Wherein the processing technology of embodiment 1 comprises the following steps:
1) by load weighted Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, sodium sulfonate, saccharin sodium,
The small powders such as glycyrrhizic acid dipotassium, pigment, preservative and water put in liquid tank, suck in Manufacturing medicine extract machine after stirring, start agitator and stir
Mix 2～3 minutes；
2) liquid material such as sorbitol, glycerol is sucked in Manufacturing medicine extract machine, start agitator and stir；
3) sodium carboxymethyl cellulose, xanthan gum, nicotiamide are put into filler bin together with the hydrated silica of half amount, and
Stir 5～10 minutes, be allowed to mix；Again material in powder cabin is sucked in Manufacturing medicine extract machine, stir 20～30 minutes；
4) surplus hydrated silica and sodium lauryl sulfate are added in Manufacturing medicine extract machine, the most quickly stirring 15 points
Clock；
5) essence (being dissolved with Borneolum Syntheticum, paeonol) measured, cocamido propyl betaine are added in Manufacturing medicine extract machine, open
Open vacuum stirring 10～15 minutes；I.e. obtain mastic.
Embodiment 2
A kind of have the toothpaste bitterly acted on that disappears that relieves inflammation or internal heat, and by percentage to the quality, the raw material of following components is prepared from: cattle
Yellow 0.03%, Radix Scutellariae extract 0.5%, Flos Lonicerae extract 1.5%, Rhizoma Cimicifugae extract 1.0%, Borneolum Syntheticum 0.05%, sulfonic acid
Sodium 1.3%, nicotiamide 0.5%, hydrated silica 20.0%, sorbitol 55.0%, Polyethylene Glycol 3.0%, sodium carboxymethyl cellulose
0.3%, carrageenan 0.4%, sodium lauryl sulfate 2.2%, essence 1.2%, sucralose 0.15%, sodium monofluorophosphate
0.8%, pigment trace (meeting national quality requirement standard), preservative trace (meet national quality requirement standard i.e.
Can), surplus be water.
The processing technology of above-described embodiment 2 comprises the following steps:
1) by load weighted Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, sodium sulfonate, trichlorine sugarcane
The small powders such as sugar, sodium monofluorophosphate, pigment, preservative and water put in liquid tank, suck in Manufacturing medicine extract machine, start agitator after stirring
Stir 2～3 minutes；
2) liquid material such as sorbitol, Polyethylene Glycol is sucked in Manufacturing medicine extract machine, start agitator and stir；
3) sodium carboxymethyl cellulose, carrageenan, nicotiamide are put into filler bin together with the hydrated silica of half amount, and
Stir 5～10 minutes, be allowed to mix；Again material in powder cabin is sucked in Manufacturing medicine extract machine, stir 20～30 minutes；
4) surplus hydrated silica and sodium lauryl sulfate are added in Manufacturing medicine extract machine, the most quickly stirring 15 points
Clock；
5) essence (being dissolved with Borneolum Syntheticum) measured is added in Manufacturing medicine extract machine, unlatching vacuum stirring 10～15 minutes；Obtain
To mastic.
Embodiment 3
A kind of have the toothpaste bitterly acted on that disappears that relieves inflammation or internal heat, and by percentage to the quality, the raw material of following components is prepared from: cattle
Yellow 0.08%, Radix Scutellariae extract 1.0%, Flos Lonicerae extract 0.5%, Rhizoma Cimicifugae extract 1.8%, Borneolum Syntheticum 0.1%, sodium sulfonate
1.0%, nicotiamide 1.5%, calcium carbonate 32.0%, hydrated silica 5%, sorbitol 30.0%, propylene glycol 3.0%, carboxymethyl is fine
Dimension element sodium 0.5%, guar gum 0.4%, sodium lauryl sulfate 2.2%, essence 1.2%, saccharin sodium 0.1%, stevioside
0.5%, strontium chloride 2.0%, pigment trace (meeting national quality requirement standard), preservative trace (meet national quality
Requirement standard), surplus be water.
The processing technology of above-described embodiment 3 comprises the following steps:
1) by load weighted Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, sodium sulfonate, saccharin sodium,
The small powders such as stevioside, strontium chloride, pigment, preservative and water put in liquid tank, suck in Manufacturing medicine extract machine, start stirring after stirring
Device stirs 2～3 minutes；
2) liquid material such as sorbitol, propylene glycol is sucked in Manufacturing medicine extract machine, start agitator and stir；
3) sodium carboxymethyl cellulose, guar gum, nicotiamide are put into filler bin together with the calcium carbonate of half amount, and stir
Mix 5～10 minutes, be allowed to mix；Again material in powder cabin is sucked in Manufacturing medicine extract machine, stir 20～30 minutes；
4) surplus calcium carbonate, hydrated silica are added in Manufacturing medicine extract machine with sodium lauryl sulfate, the most quickly
Stir 15 minutes；
5) essence (being dissolved with Borneolum Syntheticum) measured is added in Manufacturing medicine extract machine, unlatching vacuum stirring 10～15 minutes；Obtain
To mastic.
Embodiment 4
A kind of have the collutory bitterly acted on that disappears that relieves inflammation or internal heat, and by percentage to the quality, the raw material of following components is prepared from:
Calculus Bovis 0.05%, Radix Scutellariae extract 0.8%, Flos Lonicerae extract 1.1%, Rhizoma Cimicifugae extract 0.8%, Borneolum Syntheticum
0.05%, sodium sulfonate 1.0%, nicotiamide 0.5%, sorbitol 10.0%, glycerol 5.0%, propylene glycol 5.0%, poloxamer
3.0%, polysorbate-20 1.0%, cocamido propyl betaine 0.5%, essence 0.2%, saccharin sodium 0.1%, western pyrrole
Oronain 0.5%, disodium hydrogen phosphate 0.6%, sodium dihydrogen phosphate 0.3%, monochloro sodium phosphate 0.8%, pigment trace (meets country's matter
Amount requires standard), preservative trace (meeting national quality requirement standard), surplus be water.
The processing technology of above-described embodiment 4 is:
1) by load weighted Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, sodium sulfonate, saccharin sodium,
The small powders such as monochloro sodium phosphate, sodium dihydrogen phosphate, disodium hydrogen phosphate, pigment, preservative are added to the water, and stir and are allowed to molten in 2～5 minutes
Solve, obtain liquid phase；
2) liquid materials such as appropriate sorbitol, glycerol, propylene glycol are added in liquid phase, stir and be allowed to dissolve for 2～5 minutes；
3) add poloxamer, polysorbate-20, cetylpyridinium chloride, stir 5～10 minutes；Finally it is sequentially added into cocos nucifera oil
Amido propyl betaine, nicotiamide, essence (being dissolved with Borneolum Syntheticum), stirring is to forming transparent uniform solution；
4) stand, filter after to squeeze into storage tank etc. to be filled.
Embodiment 5
A kind of have the collutory bitterly acted on that disappears that relieves inflammation or internal heat, and by percentage to the quality, the raw material of following components is prepared from:
Calculus Bovis 0.1%, Radix Scutellariae extract 1.6%, Flos Lonicerae extract 0.7%, Rhizoma Cimicifugae extract 1.2%, Borneolum Syntheticum 0.1%, sulfonic acid
Sodium 0.5%, nicotiamide 1.8%, sorbitol 15.0%, propylene glycol 8.0%, poloxamer 2.5%, Cremophor RH40
1.0%, sodium lauroyl sarcosine 0.5%, essence 0.2%, sucralose 0.1%, chlorhexidine 0.5%, sodium pyrophosphate 0.5%,
Glycyrrhizic acid dipotassium 0.2%, paeonol 0.1%, pigment trace (meeting national quality requirement standard), preservative trace (symbol
Close national quality require standard), surplus be water.
The processing technology of above-described embodiment 5 is:
1) by load weighted Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, sodium sulfonate, trichlorine sugarcane
The small powders such as sugar, sodium pyrophosphate, glycyrrhizic acid dipotassium, pigment, preservative are added to the water, and stir and are allowed to dissolve for 2～5 minutes, obtain liquid
Phase；
2) liquid materials such as appropriate sorbitol, propylene glycol are added in liquid phase, stir and be allowed to dissolve for 2～5 minutes；
3) add poloxamer, Cremophor RH40, chlorhexidine, stir 5～10 minutes；Finally it is sequentially added into Laurel
Acylsarcosine sodium, nicotiamide, essence (being dissolved with Borneolum Syntheticum, paeonol), stirring is to forming transparent uniform solution；
4) stand, filter after to squeeze into storage tank etc. to be filled.
Embodiment 6
A kind of have the mouthspray bitterly acted on that disappears that relieves inflammation or internal heat, by percentage to the quality, by the raw material preparation of following components
Become:
Calculus Bovis 0.06%, Radix Scutellariae extract 2.0%, Flos Lonicerae extract 1.0%, Rhizoma Cimicifugae extract 1.4%, Borneolum Syntheticum
0.09%, sodium sulfonate 1.6%, nicotiamide 0.7%, sorbitol 12.0%, propylene glycol 8.0%, polysorbate-20
2.0%, PEG-60 castor oil hydrogenated 3.0%, menthol 0.3%, menthyl lactate 0.1%, ethanol 10.0%, essence 0.5%,
Saccharin sodium 0.15%, sodium fluoride 0.5%, pigment trace (meeting national quality requirement standard), preservative trace (meet state
Family prescription standard), surplus be water.
The processing technology of embodiment 6 is:
By load weighted Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, sodium sulfonate, saccharin sodium, fluorine
Change the small powders such as sodium, pigment, preservative to be added to the water, stir and be allowed to dissolve for 2～5 minutes, obtain liquid phase；By polysorbate-20
It is dissolved in propylene glycol, adds together with PEG-60 castor oil hydrogenated in liquid phase, be subsequently adding sorbitol, ethanol, nicotiamide, stir
Mix uniformly；Adding menthol, menthyl lactate, essence (being dissolved with Borneolum Syntheticum), stirring is to forming transparent uniform solution；After filtration
Squeeze into storage tank etc. to be filled.
Embodiment 7
A kind of have the mouthspray bitterly acted on that disappears that relieves inflammation or internal heat, by percentage to the quality, by the raw material preparation of following components
Become:
Calculus Bovis 0.05%, Radix Scutellariae extract 0.5%, Flos Lonicerae extract 2.5%, Rhizoma Cimicifugae extract 0.6%, Borneolum Syntheticum
0.06%, sodium sulfonate 0.8%, nicotiamide 0.5%, sorbitol 15.0%, glycerol 6.0%, poloxamer 2.0%, poly-Pyrusussuriensis
Alcohol ester-20 1.0%, menthol 0.3%, ethanol 8.0%, essence 0.5%, saccharin sodium 0.15%, sodium monofluorophosphate 0.8%, color
Element trace (meeting national quality requirement standard), preservative trace (meeting national quality requirement standard), surplus are
Water.
The processing technology of embodiment 7 is:
By load weighted Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, sodium sulfonate, saccharin sodium, list
The small powders such as sodium fluorophosphate, pigment, preservative are added to the water, and stir and are allowed to dissolve for 2～5 minutes, obtain liquid phase；By polysorbate
Ester-20 is dissolved in glycerol, adds in liquid phase together with poloxamer, is subsequently adding sorbitol, ethanol, nicotiamide, and stirring is all
Even；Adding menthol, essence (being dissolved with Borneolum Syntheticum), stirring is to forming transparent uniform solution；Squeeze into storage tank after filtration and wait filling
Dress.
Clinical experiment part analgesic experiment
Tested material: the present invention has, by what embodiment 1,2 prepared, toothpaste (toothpaste group 1 of the present invention, the basis that relieving inflammation or internal heat disappears acts on bitterly
Invention toothpaste group 2), diclofenac diethylamine emulgel (diclofenac group), blank (normal saline) (blank group), former
Material only comprises the toothpaste (toothpaste bare substrate group) of the base material part of embodiment 1.
Experimental technique: choose healthy Kunming female mice, hot-plate instrument temperature is controlled, at 55 ± 0.5 DEG C, to be placed on by mice
Measure the pain threshold (mice contact hot plate to the time licking metapedes) of every Mus on hot plate, all lick the metapedes time and less than 5s or be more than
30s and leaper give it up, and select qualified mice 30, are randomly divided into 5 groups.Often group mice by the same method be repeated 2 times mensuration little
The normal pain threshold of Mus, every minor tick 15 minutes, take the threshold of pain before twice normal pain threshold meansigma methods is administered as this group mice
Value.
Being coated with respectively at each group of mice metapedes and only give corresponding tested material 0.2g/, blank group is coated with and gives normal saline 0.2ml/
Only, be coated with give tested material after 3 minutes, within 20 minutes, measure the pain threshold of mice.As the most reactionless in mice 60s, mice is taken out, in order to avoid
Scalding, its pain threshold calculates with 60s.
The toothpaste that the pain that disappears relieving inflammation or internal heat according to prepared the having of embodiment 1,2 acts on carries out analgesic experiment, this toothpaste and toothpaste
Bare substrate group carries out analgesic experiment checking together as reference substance.Result is as shown in table 1:
Table 1 toothpaste to the analgesic activity of mice (N=6)
By the data of upper table it can be seen that toothpaste group of the present invention 3 minutes, 20 minutes time the pain threshold of mice is all carried
Height, but the diclofenac group that compares when 20 minutes is without clear superiority.
Being found by analgesic test: compare more blank group, the pain threshold of the toothpaste group mice of the present invention improves significantly,
The toothpaste of the prompting present invention has obvious analgesic efficacy.Clinical proof has reached the purpose of the present invention.
Clinical experiment part antiinflammatory is tested
Tested material: the present invention is by the prepared toothpaste (toothpaste group 1 of the present invention, toothpaste group 2 of the present invention) of embodiment 1,2, raw material
Only comprise the toothpaste (toothpaste bare substrate group) of the base material part of embodiment 1, (toothpaste bare substrate group), benzoic acid ointment (benzene
Formic acid ointment group), blank (normal saline) (blank group).
Experimental technique: xylol causes the antiinflammatory action of white mice ear corridor acute inflammation swelling
Choose healthy Kun Ming mice 40, be randomly divided into 5 groups, often group 8.During experiment, often organize every animal auris dextra
Inside and outside corridor, dimethylbenzene 0.1ml/ is all smeared only to scorching in two sides, and left ear is untreated does self-blank matched group.Smear dimethylbenzene
After 25min, only often organize inside and outside every animal auris dextra corridor two sides uniform application group tested material sample 0.1g/ respectively.Give tested
After thing 1h, the dislocation of white mice strength vertebra is put to death, and cuts two ear corridors, washes away auris dextra corridor tested material sample with normal saline, use dry cotton ball
Cleaning, take two circle auricles with card punch at same position chisel, it is swelling value that auris dextra sheet weight deducts left auricle weight.
Table 2 toothpaste to the antiinflammatory action of mice (N=8)
By the data of upper table it can be seen that compare more blank group, the toothpaste group of the present invention can make white mice acute inflammation swell
Swollen ear corridor value alleviates, hence it is evident that white mice ear corridor acute inflammation swelling caused by suppression dimethylbenzene, shows that the toothpaste of the present invention is to acute
Inflammation has obvious antiinflammatory action.
Treatment oral ulcer clinical trial
Oral ulcer shows: seen from oral mucosa one or more 2～the circle of 15mm or ellipse, neat in edge, table
The fester of face nick, around ulcer, blush is obvious sometimes, is often accompanied by the violent baking of comparison and burns sample pain, is especially chewing and connecing
Become apparent from when touching the irritable food such as sour, peppery.
Method: sooner or later use every day the toothpaste of the present invention to brush teeth twice, at least 3 minutes every time.Simultaneously with the use of this
Bright collutory rinsing the mouth more than 2 times, each rinsing the mouth at least 1 minute.
Criterion of therapeutical effect: cure: ulcer is cured completely, pain disappears；Take a turn for the better: ulcer surface reduces or ulcer reduces, and pain subtracts
Gently；Invalid: ulcer does not heals, pain exists.
Therapeutic outcome: in 12 examples, has 10 examples 3～ulcer healing in 7 days, and pain disappears, cure rate 83%；2 example ulcer subtract
Little, pain relief.
The oral care composition made according to the above-mentioned formula of the embodiment of the present invention, user the most once or has every day
Use during the malaise symptoms of oral cavity, can alleviate oral cavity get angry, have a toothache, the symptom such as gingival swelling and pain, oral ulcer.During without any symptom
Use oral care composition of the present invention can reduce the frequency that oral problem occurs.
Each technical characteristic of embodiment described above can combine arbitrarily, for making description succinct, not to above-mentioned reality
The all possible combination of each technical characteristic executed in example is all described, but, as long as the combination of these technical characteristics is not deposited
In contradiction, all it is considered to be the scope that this specification is recorded.
Embodiment described above only have expressed the several embodiments of the present invention, and it describes more concrete and detailed, but also
Can not therefore be construed as limiting the scope of the patent.It should be pointed out that, come for those of ordinary skill in the art
Saying, without departing from the inventive concept of the premise, it is also possible to make some deformation and improvement, these broadly fall into the protection of the present invention
Scope.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. one kind have relieve inflammation or internal heat disappear pain effect oral care composition, it is characterised in that by percentage to the quality, described in have
Relieve inflammation or internal heat disappear pain effect oral care composition be prepared from by the raw material including following components:
Calculus Bovis 0.01%～1%, Radix Scutellariae extract 0.1%～5%, Flos Lonicerae extract 0.1%～5%, Rhizoma Cimicifugae extract
0.1%～5%, Borneolum Syntheticum 0.01%～0.5%, sodium sulfonate 0.1%～5%, nicotiamide 0.1%～5%, surplus are base material.
The most according to claim 1 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that described cattle
Huang, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, Borneolum Syntheticum, sodium sulfonate, the interpolation total amount of nicotiamide account for described tool
Having relieves inflammation or internal heat disappear pain effect oral care composition 1～10%.
The most according to claim 2 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that with quality hundred
Proportion by subtraction meter, described in have relieve inflammation or internal heat disappear pain effect oral care composition be prepared from by the raw material including following components:
Calculus Bovis 0.03%～0.1%, Radix Scutellariae extract 0.5%～2.0%, Flos Lonicerae extract 0.5%～2.5%, Rhizoma Cimicifugae carry
Take thing 0.5%～2%, Borneolum Syntheticum 0.03%～0.1%, sodium sulfonate 0.5%～2.0%, nicotiamide 0.5%～2.0%, surplus
For base material；
Described Calculus Bovis, Radix Scutellariae extract, Flos Lonicerae extract, Rhizoma Cimicifugae extract, Borneolum Syntheticum, sodium sulfonate, nicotiamide interpolation total
Amount has, described in accounting for, the 3～7% of the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat.
4. relieve inflammation or internal heat the oral care composition bitterly acted on that disappears according to having described in any one of claims 1 to 3, and its feature exists
In, described oral care composition is toothpaste, collutory, mouthspray.
The most according to claim 4 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that described oral cavity
Care composition is toothpaste, and by percentage to the quality, described base material includes the raw material of following components, the percent mass of following raw materials according
Than for having the mass percent of oral care composition that pain acts on of disappearing of relieving inflammation or internal heat described in accounting for:
Grinding agent 10%～45%, wetting agent 10%～60%, binding agent 0.2%～3%, surfactant 0.5%～4%,
Essence 0.5%～3%, sweeting agent 0.1%～1%, functional additive 0～3%, pigment trace, preservative trace, water surplus,
It is described that to have the disappear mass percent summation of all raw materials of oral care composition of pain effect of relieving inflammation or internal heat be 100%.
The most according to claim 5 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that described grinding
At least one in hydrated silica, calcium carbonate, calcium hydrogen phosphate, microcrystalline Cellulose of agent；
At least one in sorbitol, glycerol, Polyethylene Glycol, propylene glycol, xylitol of described wetting agent；
At least one in sodium carboxymethyl cellulose, carrageenan, xanthan gum, guar gum of described binding agent；
Described surfactant is selected from sodium lauryl sulfate, sodium lauroyl sarcosine, sodium cocoyl methyl sodium taurocholate or coconut palm
At least one in oleamide CAB；Or
Described surfactant is: have selected from sodium lauryl sulfate, sodium lauroyl sarcosine, sodium cocoyl methyl sodium taurocholate
Or at least one in cocamido propyl betaine, also have selected from tween, polyoxyethylene and polyoxypropylene block copolymers, hydrogen
Change at least one in castor oil polyoxyethylene ether；
At least one in saccharin sodium, sucralose, stevioside, aspartame of described sweeting agent；
Described functional additive is selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or red does not has
Medicine alcohol, paeonol, eugenol, glycyrrhizic acid dipotassium.
The most according to claim 4 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that described oral cavity
Care composition is collutory, and by percentage to the quality, described base material includes the raw material of following components, the quality hundred of following raw materials according
Proportion by subtraction be account for described in there is the mass percent of oral care composition of pain effect of disappearing of relieving inflammation or internal heat:
Wetting agent 5.0%～30.0%, emulsifying agent 1.0%～10.0%, essence 0.1%～1.0%, sweeting agent 0.05%～
1.0%, antibacterial 0.01～1.0%, pH adjusting agent 0～3.0%, functional additive 0～3.0%, pigment trace, preservative are micro-
Amount, water surplus, described in there is the disappear mass percent summation of all raw materials of oral care composition of pain effect of relieving inflammation or internal heat be
100%.
The most according to claim 7 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that described moisturizing
At least one in sorbitol, glycerol, Polyethylene Glycol, propylene glycol, xylitol of agent；
Described emulsifying agent is in tween, polyoxyethylene and polyoxypropylene block copolymers, castor oil hydrogenated polyoxyethylene ether
In at least one, or
Described emulsifying agent is: have selected from tween, polyoxyethylene and polyoxypropylene block copolymers, castor oil hydrogenated polyoxyethylene ether
At least one in, also have selected from sodium lauryl sulfate, sodium lauroyl sarcosine, sodium cocoyl methyl sodium taurocholate or
At least one in cocamido propyl betaine；
At least one in saccharin sodium, sucralose, stevioside, aspartame of described sweeting agent；
Described antibacterial is selected from cetylpyridinium chloride or chlorhexidine；
Described pH adjusting agent is in disodium hydrogen phosphate, sodium dihydrogen phosphate, citric acid, sodium citrate, sodium pyrophosphate, natrium malicum
At least one；
Described functional additive is selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or red does not has
Medicine alcohol, paeonol, eugenol, glycyrrhizic acid dipotassium.
The most according to claim 4 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that described oral cavity
Care composition is mouthspray, and by percentage to the quality, described base material includes the raw material of following components, the quality of following raw materials according
Percentage ratio be account for described in there is the mass percent of oral care composition of pain effect of disappearing of relieving inflammation or internal heat:
Wetting agent 5%～40.0%, emulsifying agent 1%～10.0%, flavoring agent 0.1～3.0%, ethanol 0～20.0%, essence
0.1%～2.0%, functional additive 0～3.0%, pigment trace, preservative trace, water surplus, described in there is the relieving inflammation or internal heat pain that disappears make
The mass percent summation of all raw materials of oral care composition be 100%.
The most according to claim 9 have the oral care composition bitterly acted on that disappears that relieves inflammation or internal heat, it is characterised in that described guarantor
At least one in sorbitol, glycerol, Polyethylene Glycol, propylene glycol, xylitol of humectant；
Described emulsifying agent is in tween, polyoxyethylene and polyoxypropylene block copolymers, castor oil hydrogenated polyoxyethylene ether
At least one；
Described flavoring agent is selected from least in menthol, Borneolum Syntheticum, menthyl lactate, saccharin sodium, sucralose, stevioside
Kind；
Described functional additive is selected from sodium fluoride, sodium monofluorophosphate or potassium nitrate, strontium chloride or zinc citrate, zinc lactate or red does not has
Medicine alcohol, paeonol, eugenol, glycyrrhizic acid dipotassium.
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