CN108478500A - A kind of composition and its application for oral cavity - Google Patents

Abstract

The present invention relates to a kind of composition for oral cavity and its applications.The composition for oral cavity includes the component of following parts by weight：0.05 5 parts by weight of rosemary leaf extract；0.1 2.5 parts by weight of leaf of Mentha piperita extract；0.06 4 parts by weight of medicine extracts of Salvia officinalis leaves.Oral cavity can be not only cleaned provided by the present invention for the composition in oral cavity, also has both and removes oral helicobacter pylori, clearing heat and removing internal heat and other effects.

Description

A kind of composition and its application for oral cavity

Technical field

The present invention relates to a kind of composition for oral cavity and its applications, belong to daily chemical products technical field.

Background technology

Helicobacter pylori (Helicobacter pylori, H.pylori) is a kind of monopole, more flagellums, helically bent Gram-negative bacteria, size be (0.3~1.0) μ m (2.0~5.0) μm.Helicobacter pylori is have high infection rate slow Sexy metachromia pathogenic bacteria, Hp infection is infectious diseases, does not have " to carry " state.Hp infection is chronic active gastritis and digestion The Etiological of property ulcer, it is closely related with the morbidity of gastric mucosa-associated lymphoid tissue lymphoma, gastric cancer.Some researches show that oral cavities There are certain relevance between Hp in Hp and stomach, oral cavity may be another important aggregation ground of Hp, and find that oral cavity Hp feels Dye person is easier that periodontosis occurs, and the recall rate of Hp and the severity of periodontosis and activity are proportionate in oral cavity.

Oral cavity occur pharyngodynia with dryness, two furious red, nasal cavities it is hot dry, nose is bleeding and dry glossalgia, swelling and aching of gum, oral cavity are burst The symptoms such as ulcer and the tip of the tongue erosion, angular chilitis, aphthae, toothache, Chinese medicine are taken as " getting angry ".When people's operating pressure is big, Diet is unhealthy, Smoking And Drinking, and often overtime work is stayed up late, and work and rest is irregular, and working environment is severe, and immunity is caused to reduce, and is just held It gets angry in easy oral cavity.

It can be seen from the above, the helicobacter pylori in oral cavity has great harm to the health of human body；Oral cavity excessive internal heat pair People’s lives quality has the negative effect that can not be ignored, and the happiness of people's daily life is made to reduce.In order to restore as early as possible The oral environment of health, people's generally use drug therapy solve the above problems.But drug administration can cause human body certain Side effect, it is therefore necessary to provide other external treatment modes to solve unhealthy phenomenon existing for the oral cavity of part.

Invention content

To solve the above-mentioned problems, the present invention provides a kind of dental products, can not only clean oral cavity, also have both removing Oral helicobacter pylori, clearing heat and removing internal heat and other effects.

The present invention adopts the following technical scheme that realization.

A kind of composition for oral cavity includes the component of following parts by weight：

Rosemary leaf extract 0.05-5 parts by weight；

Leaf of Mentha piperita extract 0.1-2.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.06-4 parts by weight.

Preferably, the composition for oral cavity includes the component of following parts by weight：

Rosemary leaf extract 0.2-3 parts by weight；

Leaf of Mentha piperita extract 0.2-1.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.1-2 parts by weight.

Further preferably, the composition for oral cavity includes the component of following parts by weight：

Rosemary leaf extract 0.8-1.2 parts by weight；

Leaf of Mentha piperita extract 0.2-0.8 parts by weight；

Medicine extracts of Salvia officinalis leaves 1.2-1.6 parts by weight.

In the present invention, the rosemary (Rosmarinus officinalis L.) also known as oil grass, alias ocean it Dew, tansy etc..It is rosemary fragrant odour, strong, refrigerant, it is Labiatae Rosmarinus, perennial evergreen undershrub plant, master The chemical composition wanted includes terpene, flavonoids, organic acid, aliphatic acid, multibranched paraffin, boots matter and amino acid etc..Wherein, phenol two Carnosic acid and carnosol in terpene are most important antioxidant contents.Rosemary is a kind of important natural perfume plant, It is widely used in the fields such as daily-use chemical industry, food additive adduction medicines and health protection.It is rich in a variety of antioxidant contents efficiently, safe, It is a kind of generally acknowledged at present plant having compared with high anti-oxidation effect, can effectively removes interior free yl.Rosemary is potent Anti-corrosive antibacterial acts on.Rosemary Oil has sterilization, desinsection, anti-inflammatory isoreactivity.It is the excellent inoxidizability of Rosmarinus officinalis extract, resistance to The characteristics such as thermal stability, high-efficiency broad spectrum will be such that it has in food, medicine and health products, cosmetic field more wide Application prospect.

Rosemary leaf extract of the present invention, can be used the method extraction of this field routine, or be passed through by rosemary leave 65% ethyl alcohol is with solid-to-liquid ratio (mg/L) 1:10 impregnate made from gained extract.

Peppery peppermint (Mentha piperita L.) is first generation sterile variety made of fish mint hybridizes with spearmint, is Labiatae Mentha herbaceos perennial, alias Europe peppermint, pennyroyal mint, American mint.The plant has inducing diaphoresis, evacuation wind The effects that heat, pharynx-clearing throat-benefiting, cool health care product have essential wind oil, white flower oil etc. made of it.As natural rare spice crop, The essential oil that its cauline leaf refines is widely used in luxury food, superior cosmetics and medical and health etc. because quality is excellent.Mainly Containing 118 kinds of ingredients such as menthones, menthol, menthyl acetate, aroma of pure is salubrious pleasant.In addition, peppery peppermint is to golden yellow Staphylococcus, Escherichia coli, Pseudomonas aeruginosa etc. have inhibiting effect.

Leaf of Mentha piperita extract of the present invention, can be used the method extraction of this field routine, or be passed through by leaf of Mentha piperita 65% ethyl alcohol is with solid-to-liquid ratio (mg/L) 1:10 impregnate made from gained extract.

Salvia japonica (Salvia officinalis) is Labiatae, salvia, a biennial or perennial herb Plant and evergreen dwarf shrub, leaf, stem and Hua Junyou very high utility value.Salvia japonica has limpid fragranced, can be used for expecting Reason, tea-drinking, beauty, health, essential oil, floriculture etc.；Have anti-corrosion, antibacterial, remove free radical, it is anti-oxidant, it is anti-mutation, strengthen nerve, Antipyretic, body-building promotes digestion anti-inflammatory, protection stomach and adjusts immune and other effects.Salvia japonica is very ancient medicinal in Europe The Fragrant vegetables of plant or the low aluminium of a kind of hyperkalemia hyponatremia, high calcium.So Salvia japonica integrates edible, medicinal and health care, It is widely paid close attention to, becomes a research hotspot.

The method extraction of this field routine can be used in medicine extracts of Salvia officinalis leaves of the present invention, or by medicine Salvia japonica Leaf is through 65% ethyl alcohol with solid-to-liquid ratio (mg/L) 1:10 impregnate made from gained extract.

Preferably, the composition further includes rhizoma anemarrhenae, Cortex Phellodendri, radix scutellariae, the coptis, kuh-seng, cape jasmine, Prunella vulgaris, lophatherum gracile, wears One or more of heart lotus, honeysuckle, dandelion.

Wherein, dosage is each component in the composition：

It is further preferred that the composition for oral cavity includes the component of following parts by weight：

It is further preferred that the composition for oral cavity includes the component of following parts by weight：

It can further significantly it is an unexpected discovery of the invention that adding one or more of above-mentioned raw materials in above-mentioned composition The effect of improving composition.

Above-mentioned rhizoma anemarrhenae be liliaceous plant rhizoma anemarrhenae (Anemarrhena asphodeloides Bge) rhizome, bitter, It is cold in nature, return lung, stomach, kidney channel.With clearing heat-fire, nourishing Yin and moistening dryness, relieving restlessness and other effects of quenching the thirst.Contain a large amount of steroidals in Asphodeloides Bge Rhizome Saponin(e, double benzene pyrrones, lignanoids, polysaccharide, organic acid, a large amount of mucilaginous substances and trace element etc..With anti-inflammatory, anti- Bacterium, antiviral, anti-platelet aggregation, hypoglycemic, antitumor, anti-aging and anti-dull-witted, anti-oxidant, antidepression, improvement sclerotin are dredged The effects that loose.

Cortex Phellodendri is the dry bark of rutaceae wampee (Phellodendron chinense Schneid.).It practises Claim " CORTEX PHELLODENDRI CHINENSE ".Cortex Phellodendri bitter trembles with fear, returns kidney, bladder warp.With heat-clearing and damp-drying drug, purging intense heat, except steaming, detoxification sore treatment and other effects.There is tune The effects that saving blood glucose, gastrointestinal function, blood pressure lowering, antibacterial, anti-inflammatory, antipyretic, antitumor, adjusting promoted to be immunized and is anti-oxidant.Cortex Phellodendri Extract is for treating department of stomatology common disease, such as periodontitis, acute ulcerative gingivitis, stomatocace, swelling and aching of gum Deng, have antibacterial anti-inflammatory, heat-clearing treat sore, wound healing the effect of.As it is common cure mainly aphthae prescription it is important in Medicine is used widely.

Radix scutellariae is the dry root of labiate radix scutellariae (Scutellaria baicalensis Georgi).Radix scutellariae is containing Huang A kind of reed mentioned in ancient books aglycon, scutelloside, wogonin, wogonoside, neobaicalein, acetophenone, palmitic acid, oleic acid, proline, benzoic acid, Huang A kind of reed mentioned in ancient books enzyme, cupreol.Modern research shows that radix scutellariae is to hemolytic streptococcus, Diplococcus pneumopniae, influenza virus, typhoid bacillus, dysentery Shigella, Pseudomonas aeruginosa, tubercle bacillus, staphylococcus aureus have inhibiting effect.Draft additive of the scutelloside as toothpaste There are hemostasis, anti-inflammatory, except a variety of curative effects such as halitosis and callus.

The coptis is the ranunculaceae plant coptis (Coptis chinensis Franch.), the triangle leaf coptis (Coptis Deltoidea C.Y.Cheng et Hsiao) or cloud connect (Coptis teeta Wall.) dry rhizome.The coptis mainly has There is many-sided effect such as antibacterial, antiviral, antiendotoxin, antiprotozoan, can inhibit.Jamaicin in the coptis, to a variety of leather orchid Positive and negative bacterium has inhibiting effect.Berberine has obvious inhibiting effect to helicobacter pylori in vitro, cheap, Safety is good.

Kuh-seng is the dry root of legume kuh-seng (Sophora flavescens Ait.).First recorded in《Legendary god of farming's book on Chinese herbal medicine Through》, middle product are classified as, taste is extremely bitter, cold in nature, has the effects that heat-clearing and damp-drying drug, desinsection, diuresis.Kuh-seng belongs to the heat-clearing in antipyretic Eliminating dampness medicine is used for hot dysentery, has blood in stool, jaundice renal shutdown, leukorrhea with reddish discharge, swelling of vulva pruritus vulvae, eczema, wet sore, pruitus, mange leprosy. The main pharmacological of kuh-seng has anti-arrhythmia, resisting myocardial fibrillation, antitumor, anti-inflammatory, resisting pathogenic microbes, anti-liver injury And the adjustment effect etc. to immune system and nervous system.Matrine has inhibiting effect, kuh-seng water to drug resistance helicobacter pylori Decocting liquid to Escherichia coli, staphylococcus aureus, alpha streptococcus, beta streptococcus, shigella dysenteriae, dimension from dysentery Salmonella with And proteus has obvious inhibiting effect.

Cape jasmine is the dry mature fruit of madder wort cape jasmine (Gardenia jasminoides Ellis).Bitter, It is cold in nature.The thoughts of returning home, lung, tri-jiao channel.With purging intense heat relieving restlessness, clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body and other effects.Cape jasmine has anti-inflammatory, antipyretic, town Bitterly, the effects that liver protection, cholagogic, reducing blood lipid, antithrombotic, neuroprotection, tranquilizing soporific.Clinic is widely used in Vexed, jaundice Urinate the cards such as red, blood strangury and dry pain, blood-head tells nosebleed, red eye, swell pain, pathogenic fire,toxin and furuncles；Its root functionality heat-clearing, cool blood, removing toxic substances, it is civil main Treatment for illnesss such as icterepatitis, nephritic dropsy, flu high fever, bleeding haematemesis, traumatic injury, sore swollen toxins；Ye Ke Swelling and pain relieving treats traumatic injury；Flower can the hot cool blood lipid-loweringing of clearing lung-heat, treatment cough with lung heat, nosebleed epistaxis.Also treatment oral cavity is useful for burst The report of ulcer.

Prunella vulgaris is the drying fruit ear of labiate Prunella vulgaris (Prunella vulgaris L.).Change in Prunella vulgaris Study point includes mainly the multiclass ingredients such as triterpene, steroidal, flavones, cumarin, organic acid.Prunella vulgaris has apparent anti-inflammatory antipyretic Analgesic activity has very strong resistant function, extract and active constituent sieve danshinolic acid to mitigating vascular inflammation Earlier period of inflammation And periodontal disease etc. all has certain effect.Prunella vulgaris is other than it can inhibit the nonspecific mental retardation of inflammatory reaction, to spy Specific immunological also shows great inhibiting effect.In addition, finding that Prunella vulgaris water decoction is anti-with wide spectrum by experiment in vitro Bacterium activity, gram-Negative bacillus and gram-positive bacteria are all had a strong inhibitory effect, to shigella dysenteriae, typhoid bacillus, Comma bacillus, Escherichia coli, Pseudomonas aeruginosa and staphylococcus, streptococcus etc. have inhibiting effect, and its flooding agent is to certain normal The pathogenic dermatophyte seen also has certain inhibiting effect.Prunella vulgaris stem, leaf, fringe and herb have antihypertensive effect, study table Bright Prunella vulgaris antihypertensive effect is related with Prunella vulgaris total saposins.Prunella vulgaris is also antiviral, hypoglycemic, reducing blood lipid, antitumor, antioxygen The effects that change, Green Tea Extract, calm, hypnosis.

Lophatherum gracile is the drying cauline leaf of grass henon bamboo leaf (Lophatherum gracile Brongn.).Sweet in flavor, It is light, it is cold in nature.The thoughts of returning home, stomach, small intestinl channel.With clearing heat-fire, the effect of relieving restlessness is quenched the thirst, inducing diuresis for treating strangurtia.Containing a large amount of in lophatherum gracile Flavone compound and bioactive polysaccharide and other active components, in phenolic acid compound, anthraquinone analog compound, terpene Ester, amino acid and manganese, zinc, selenium and other trace elements.Modern pharmacology proves that lophatherum gracile has antipyretic, diuresis, antibacterial action, clinically It is usually used in treating pyreticosis polydipsia, aphthae, swelling and aching of gum, children's crying with fear, cough with lung heat, stomach hot vomiting, hot urination stranguria with turbid discharge Deng card.In addition to it can be used for medicinal purpose, lophatherum gracile can be additionally used in the fields such as health care of food product.Herba Lophatheri extract is added to oral care In articles for use, bleeding gums symptom is can obviously improve, achievees the purpose that preventing oral cavity gets angry.

Herba Andrographitis is the drying of acanthaceous plant Herba Andrographitis (Andrographis paniculata (Burm.f.) Nees) Aerial part.Bitter, it is cold in nature；The thoughts of returning home, lung, large intestine, bladder warp have effects that clearing heat and detoxicating, cool blood detumescence, are widely used in Treat bacillary dysentery, acute tonsillitis, influenza and venomous snake bite etc..Main component contain diterpenoid-lactone, sterol, Flavone compound, alkaloid etc..Andrographolide have it is antipyretic, analgesia, it is anti-inflammatory, antitumor, antiviral, anti-oxidant, immune Adjusting and Hepatocyte protection.The treatment of inflammation-related diseases, such as larynx are widely used in China and Asia other countries at present The scorching, infection of the upper respiratory tract and rheumatic arthritis.Have it is experimentally confirmed that Andrographis Paniculata can treat canker sore.

Honeysuckle is Caprifoliaceae (Caprifoliaceae) Lonicera (Lonicera Linn.) plant honeysuckle (Lonicera Japonica Thunb.) dry flower, be conventional Chinese medicine, applicating history is long, there is the effect of clearing heat and detoxicating, wind-heat dissipating. It is clinically used for ulcerative carbuncle, larynx numbness, warm blood fulminant dysentery, anemopyretic cold, warm disease heating etc..Honeysuckle flower water or ethanol extract have more wide General pharmacological action includes mainly anti-inflammatory, antipyretic, antibacterial, antiviral, antimycotic, antiendotoxin, decompression, hepatic cholagogic, antibiosis It educates, is anti-oxidant, hemostasis and immunological regulation etc..Honeysuckle plays the role of clearing heat and removing internal heat, anti-inflammatory analgetic in toothpaste and removes halitosis.

Dandelion is feverfew dandelion (TaraxacummongolicumHand.-Mazz.), alkali ground dandelion (TarxacumborealisinenseKitam.) or the drying herbs of several plants is belonged to.For broad spectrum antimicrobial agent, have anti-true Bacterium, protection stomach and intestine, blood glucose, improves vascular function, immunological regulation, resists antiviral, anti-inflammatory, anti-oxidant, antitumor, hepatic cholagogic The effects that tired.It can inhibit the growth of oral cavity Hp in the oral cavity, treatment recurrent oral ulceration, remove halitosis；Taking can be with Treat gastric and duodenal ulcer etc..

Above-described rhizoma anemarrhenae, Cortex Phellodendri, radix scutellariae, the coptis, kuh-seng, cape jasmine, Prunella vulgaris, lophatherum gracile, Herba Andrographitis, honeysuckle, The required extract of the present invention is prepared using aqueous extraction-alcohol precipitation technology in dandelion.Preferably, the solid-to-liquid ratio of liquid and solvent (mg/L) it is 1:10.

The present invention also provides the compositions described in an any of the above-described technical solution to prepare for treating bleeding gums, suppression Application in the oral care product of oral bacteria processed.

The present invention provides a kind of toothpaste, includes the component of following parts by weight：

Active component：

Rosemary leaf extract 0.05-5 parts by weight；

Leaf of Mentha piperita extract 0.1-2.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.06-4 parts by weight；

Auxiliary material：

Preferably, the toothpaste includes the component of following parts by weight：

Active component：

Rosemary leaf extract 0.2-3 parts by weight；

Leaf of Mentha piperita extract 0.2-1.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.1-2 parts by weight；

Auxiliary material：

The rubbing agent is selected from silica, hypophosphite monohydrate hydrogen calcium, calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide, chlorination One or more of sodium or calcium pyrophosphate；

The moisturizer is selected from sorb (sugar) alcohol, glycerine, propylene glycol, polyethylene glycol-8 or one kind or several in butanediol Kind；

The foaming agent is selected from lauryl sodium sulfate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid One or more of sodium or cocounut oil acyl methyl taurine sodium；

The thickener is selected from cellulose and its derivates, melon glue, sodium alginate, xanthans, guar gum hydroxypropyl three One or more of ammonio methacrylate, carrageenan or locust tree fresh kidney beans；

The sweetener is selected from saccharin sodium, Sucralose, xylitol, honey element, Aspartame, stevioside or sweet Momordica grosvenori One or more of glycosides；

The essence is selected from one or more of vanilla, spearmint, minty note or Chinese ilex peppermint；

The one kind or several of the preservative in benzoic acid and its esters, sorbic acid and its esters or parabens Kind；

The appearance modifying agents are selected from titanium dioxide, food coloring, food color lake or one or more of the particle that cleans the teeth；

The solvent is selected from deionized water.

Preferably, the toothpaste further includes a kind of following ingredient：

The present invention also provides a kind of preparation methods of above-mentioned toothpaste, including：Above-mentioned composition is mixed, toothpaste is made.Tool Steps are as follows for body：

A, by rosemary leaf extract, leaf of Mentha piperita extract, medicine extracts of Salvia officinalis leaves, be dissolved in moisturizer, it is high Speed stirring, is prepared into the first mixed liquor；

B, thickener is added in the first mixed liquor, stirring obtains the second mixed liquor；

C, appearance modifying agents are added into the second mixed liquor, stirs, obtains third mixed liquor；

D, third mixed liquor, sweetener, rubbing agent, essence, foaming agent, preservative are added into solvent, stirring obtains the Four mixed liquors；

E, the 4th mixed liquor continues to stir at vacuum condition 0.08-0.12MPa, and lotion is made；

F, it examines, sterile filling enters in aluminum plastic composite pipe, seals, and toothpaste is made.

The present invention also provides a kind of mouthwashes, include the component of following parts by weight：

Active component：

Rosemary leaf extract 0.05-5 parts by weight；

Leaf of Mentha piperita extract 0.1-2.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.06-4 parts by weight；

Auxiliary material：

The solvent is selected from deionized water；

The moisturizer is selected from one or more of sorb (sugar) alcohol, propylene glycol, glycerine, polyethylene glycol-8；

The surfactant is selected from poloxamer188, lauryl sodium sulfate, sodium lauroyl sarcosine, cocounut oil acyl first One or more of base sodium taurocholate；

The thickener is selected from one or more of cellulose, card wave, carragheen；

The food flavor is selected from cloves, Chinese cassia tree perfume, fragrance of osmanthus, peppermint oil, vanilla, spearmint, minty note, Chinese ilex One or more of peppermint；

The colorant is selected from one or more of green, blue, red.

It is furthermore preferred that above-mentioned mouthwash further includes following ingredient：

Technical solution of the present invention has the advantages that：

The present invention gives full play to the synergistic function between each ingredient so that institute using the different medical mechanism of each ingredient The composition obtained can remove oral helicobacter pylori, while also have effects that clearing heat and removing internal heat.

Specific implementation mode

The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..

A kind of compositions for oral cavity of embodiment 1-4

The formula of comparative example 1~3 and Examples 1 to 3 is shown in Table 1.

Table 1：Formula

Examples 1 to 3 is composition provided by the invention in table 1, when specifically used, can be mixed with auxiliary material appropriate At oral preparations such as toothpaste or mouthwashes.

A kind of compositions for oral cavity of embodiment 4-7

The formula of comparative example 4~7 and embodiment 4~7 is shown in Table 2.

Table 2：Formula

Embodiment 4~7 is composition provided by the invention in table 2, when specifically used, can be mixed with auxiliary material appropriate At oral preparations such as toothpaste or mouthwashes.

A kind of toothpaste of embodiment 9-12

For the advantageous effect that the present invention is further explained, the present invention is by comparative example 1~3, the combination in Examples 1 to 3 Object and auxiliary material appropriate, are prepared into toothpaste.

(1) formula of comparative example 8~10 and embodiment 8~10 is shown in Table 3.

Table 3：Formula

(2) preparation method (when being free of certain ingredient in certain toothpaste, the ingredient is not added in preparation process) of toothpaste

A, by rosemary leaf extract, leaf of Mentha piperita extract, medicine extracts of Salvia officinalis leaves be dissolved in sorb (sugar) alcohol and In polyethylene glycol-8, high-speed stirred 10min is prepared into the first mixed liquor；

B, xanthans is added in the first mixed liquor, stirs 10min, obtains the second mixed liquor；

C, titanium dioxide is added in the second mixed liquor, is stirred 10min, is obtained third mixed liquor；

D, third mixed liquor be added water, saccharin sodium, xylitol, silica, minty note, cocounut oil acyl methyl taurine sodium, Potassium sorbate stirs the 4th mixed liquors of 10min；

E, the 4th mixed liquor continues to stir 15min in the case where vacuum condition is 0.08-0.12MPa, and lotion is made；

F, it examines, sterile filling enters in aluminum plastic composite pipe, seals, and toothpaste is made.

Compliance test result 1

(1) human trial (oral cavity excessive internal heat)

The inclusion criteria of experimental subjects is：Between age 18-65 Sui, remaining tooth >=16 tooth in mouth, no systemic disease, merely Oral cavity get angry, adjoint symptom is：Swelling and aching of gum, toothache, aphthae these symptoms crowd.

Experimental subjects participates in the normal individual trial experiment of toothpaste, is grouped at random according to test specimen number, every group of 25 people, respectively Group is respectively using toothpaste described in embodiment 8-10 and comparative example 8-10, and daily sooner or later respectively using once, observation uses the mouth after 7d Chamber recovery situation.

Curative effect determinate standard is as follows：

It is effective：Swelling and aching of gum, toothache, aphthae these symptoms disappearance, and no relapse after two weeks.

Effectively：Swelling and aching of gum, toothache, aphthae these symptoms make moderate progress, but do not completely eliminate.

In vain：Excessive internal heat symptom in patient oral cavity is not alleviated, still has swelling and aching of gum, toothache, aphthae these symptoms, even Exacerbation of symptoms.

Treat total effective rate=(effective+effective)/total number of cases × 100%.

As a result such as table 4：

(2) human trial (removing oral helicobacter pylori)

By comparative example 1~3, the sterile liquid of equivalent is respectively prepared in composition described in Examples 1 to 3, is packed into sterile test tube In it is spare；

Choose the following strain for causing mouth disease：Helicobacter pylori, gold-coloured staphylococci, Candida albicans, deformation hammer Bacterium；Choose caseinhydrolysate (MH) meat soup, agar medium.Standard strain takes a ring after passing on pure culture, with oese Strain is inoculated in 37 DEG C of constant incubator cultures in MH broth bouillons and identifies bacterium amount through turbidimetry and count for 6 hours.It takes identical Amount cultivates 6 hours test bacteria liquids, and bacterium solution is spread evenly across to MH agar plate surfaces respectively with sterile cotton swab, slightly dry rear use Aseptic nipper distinguishes the circle filter paper of the sterile liquid of draws equal amounts comparative example 1~3 and Examples 1 to 3, and note is in MH agar plate tables Antibacterial circle diameter (mm) is observed and measured to face, 37 DEG C of insulating box cultures in 24 hours, and bacteriostatic experiment is repeated 3 times, and antibacterial result is 3 times Laboratory mean values obtain 5 result of table.

As a result such as table 5：

The MH broth bouillons containing equivalent comparative example 1~3 and Examples 1 to 3 sterile liquid medicine are taken, are inoculated with equivalent respectively Test bacterium solution 0.05ml (10⁵CFU/ml), and with sterile MH broth bouillons identical strain is inoculated with as a contrast, in 37 DEG C of constant temperature Case culture is obtained after 24 hours such as 6 conclusion of table.

As a result such as table 6：

" +++ " bacterium obviously grows；"+" bacterium reduces growth；" 0 " takes culture medium in inoculation asepsis growth.

Above-mentioned experiment can confirm that the present invention has helicobacter pylori certain inhibiting effect, at the same time, moreover it is possible to press down The growth of other bacteriums in donsole chamber.

A kind of toothpaste of embodiment 11-14

For the advantageous effect that the present invention is further explained, the present invention is by comparative example 4~7, the combination in embodiment 4~7 Object and functional auxiliary materials appropriate, are prepared into toothpaste, pedestrian's body proof test of going forward side by side, and the beneficial effect of the present invention is proved deeper into ground Fruit.

(1) formula of comparative example 11~14 and embodiment 11~14 is shown in Table 7.

As a result such as table 7：

Table 7：Formula

(2) not preparation method (when being free of certain ingredient in certain toothpaste, the ingredient is not added in preparation process)

A, rosemary leaf extract, leaf of Mentha piperita extract, medicine extracts of Salvia officinalis leaves, anemarrhena asphodefoides extract, Cortex Phellodendri are carried It takes object, Baical Skullcap root P.E, coptis extract, shrubby sophora extract, capejasmine extract, Prunella vulgaris extract, Herba Lophatheri extract, wear Heart lotus extract, Honegsukle flower P.E, dandelion extract are dissolved in sorb (sugar) alcohol and polyethylene glycol-8, high-speed stirred 10min is prepared into the first mixed liquor；

B, xanthans is added in the first mixed liquor, stirs 10min, obtains the second mixed liquor；

C, titanium dioxide is added in the second mixed liquor, is stirred 10min, is obtained third mixed liquor；

D, third mixed liquor be added water, saccharin sodium, xylitol, silica, minty note, cocounut oil acyl methyl taurine sodium, Potassium sorbate stirs the 4th mixed liquors of 10min；

E, the 4th mixed liquor continues to stir 15min in the case where vacuum condition is 0.08-0.12MPa, and lotion is made；

F, it examines, sterile filling enters in aluminum plastic composite pipe, seals, and toothpaste is made.

Compliance test result 2

(1) human trial (oral cavity excessive internal heat)

The inclusion criteria of experimental subjects is：Between age 18-65 Sui, remaining tooth >=16 tooth in mouth, no systemic disease, merely Oral cavity get angry, adjoint symptom is：Swelling and aching of gum, toothache, aphthae these symptoms crowd.

Experimental subjects participates in the normal individual trial experiment of toothpaste, is grouped at random according to test specimen number, every group of 25 people, respectively Group is respectively using toothpaste described in embodiment 11-14 and comparative example 11-14, and daily sooner or later respectively using once, observation uses after 7d Oral cavity recovery situation.

Curative effect determinate standard is as follows：

It is effective：Swelling and aching of gum, toothache, aphthae these symptoms disappearance, and no relapse after two weeks.

Effectively：Swelling and aching of gum, toothache, aphthae these symptoms make moderate progress, but do not completely eliminate.

In vain：Excessive internal heat symptom in patient oral cavity is not alleviated, still has swelling and aching of gum, toothache, aphthae these symptoms, even Exacerbation of symptoms.

Treat total effective rate=(effective+effective)/total number of cases × 100%.

As a result such as table 8：

In order to prove the effect of the present invention, 25 people for meeting above-mentioned standard are chosen as experimental subjects, take Niuhuang Shangqing Piece is compared with above-described embodiment 12, and the crowd of 12 groups of embodiment improvement phenomenon occurs better than taking Niuhuang Shangqing Tablets after 2d Group, two groups of effective percentage is essentially identical after 7d.It gets angry when with simple oral cavity, adjoint symptom is：Gum is red and swollen, toothache, Using the toothpaste of the present invention while crowd of these symptoms of aphthae takes Niuhuang Shangqing Tablets, the improvement phenomenon after 2d is apparent Toothpaste of the present invention is used with simple better than simple Niuhuang Shangqing Tablets of taking, and the effective percentage after 7d has reached 100%.

(2) human trial (inhibiting helicobacter pylori)

By comparative example 4~7, the sterile liquid of equivalent is respectively prepared in embodiment 4~7, is fitted into spare in sterile test tube；

Choose the following strain for causing mouth disease：Helicobacter pylori, gold-coloured staphylococci, Candida albicans, deformation hammer Bacterium；Choose caseinhydrolysate (MH) meat soup, agar medium.Standard strain takes a ring after passing on pure culture, with oese Strain is inoculated in 37 DEG C of constant incubator cultures in MH broth bouillons and identifies bacterium amount through turbidimetry and count for 6 hours.It takes identical Amount cultivates 6 hours test bacteria liquids, and bacterium solution is spread evenly across to MH agar plate surfaces respectively with sterile cotton swab, slightly dry rear use Aseptic nipper distinguishes the circle filter paper of the sterile liquid of draws equal amounts comparative example 4~7 and embodiment 4~7, and note is in MH agar plate tables Antibacterial circle diameter (mm) is observed and measured to face, 37 DEG C of insulating box cultures in 24 hours, and bacteriostatic experiment is repeated 3 times, and antibacterial result is 3 times Laboratory mean values obtain 9 result of table.

As a result such as table 9：

The MH broth bouillons containing 4~7 liquid of equivalent comparative example 4~7 and embodiment are taken, are inoculated with the experiment of equivalent respectively Bacterium solution 0.05ml (10⁵CFU/ml it), and with sterile MH broth bouillons is inoculated with identical strain as a contrast, is trained in 37 DEG C of insulating boxs It is obtained such as following table conclusion after supporting 24 hours.

As a result such as table 10：

" +++ " bacterium obviously grows；"+" bacterium reduces growth；" 0 " takes culture medium in inoculation asepsis growth.

The above results are it is found that further add anemarrhena asphodefoides extract, phellodendron extract, Baical Skullcap root P.E, coptis extract, hardship Conopsea extraction, capejasmine extract, Prunella vulgaris extract, Herba Lophatheri extract, Andrographis Paniculata, Honegsukle flower P.E, Pu Gong English extract can make the present invention of gained obtain more effect, i.e., anemarrhena asphodefoides extract, phellodendron extract, Baical Skullcap root P.E, Coptis extract, shrubby sophora extract, capejasmine extract, Prunella vulgaris extract, Herba Lophatheri extract, Andrographis Paniculata, gold and silver It flower extract, dandelion extract and is made of rosemary leaf extract, leaf of Mentha piperita extract, medicine extracts of Salvia officinalis leaves There is synergistic function between composition.

A kind of mouthwashes of embodiment 15-21

The formula of embodiment 15~21 is shown in Table 11.

Table 11：Formula

Although above the present invention is described in detail with a general description of the specific embodiments, On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause This, these modifications or improvements, belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.

Claims (10)

1. a kind of composition for oral cavity, which is characterized in that include the component of following parts by weight：

Rosemary leaf extract 0.05-5 parts by weight；

Leaf of Mentha piperita extract 0.1-2.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.06-4 parts by weight.

2. composition according to claim 1, which is characterized in that the composition for oral cavity includes following parts by weight Component：

Rosemary leaf extract 0.2-3 parts by weight；

Leaf of Mentha piperita extract 0.2-1.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.1-2 parts by weight.

3. composition according to claim 1, which is characterized in that the composition further includes that anemarrhena asphodefoides extract, Cortex Phellodendri carry It takes object, Baical Skullcap root P.E, coptis extract, shrubby sophora extract, capejasmine extract, Prunella vulgaris extract, Herba Lophatheri extract, wear One or more of heart lotus extract, Honegsukle flower P.E, dandelion extract；

Preferably, dosage is each component in the composition：

It is further preferred that the composition for oral cavity includes the component of following parts by weight：

It is further preferred that the composition for oral cavity includes the component of following parts by weight：

4. preparing the oral cavity for treating bleeding gums, inhibiting oral bacteria according to any compositions of claim 1-3 Application in care product.

5. a kind of toothpaste, which is characterized in that include the component of following parts by weight：

Active component：

Rosemary leaf extract 0.05-5 parts by weight；

Leaf of Mentha piperita extract 0.1-2.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.06-4 parts by weight；

Auxiliary material：

6. toothpaste according to claim 5, which is characterized in that include the component of following parts by weight：

Active component：

Rosemary leaf extract 0.2-3 parts by weight；

Leaf of Mentha piperita extract 0.2-1.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.1-2 parts by weight；

Auxiliary material：

7. toothpaste according to claim 5, which is characterized in that the rubbing agent be selected from silica, hypophosphite monohydrate hydrogen calcium, One or more of calcium phosphate dibasic anhydrous, calcium carbonate, aluminium hydroxide, sodium chloride or calcium pyrophosphate；

The moisturizer is selected from one or more of sorb (sugar) alcohol, glycerine, propylene glycol, polyethylene glycol-8 or butanediol；

The foaming agent be selected from lauryl sodium sulfate, sodium lauroyl sarcosine, sodium cocoyl glycinate, acyl glutamic acid sodium or One or more of cocounut oil acyl methyl taurine sodium；

The thickener is selected from cellulose and its derivates, melon glue, sodium alginate, xanthans, guar hydroxypropyltrimonium One or more of ammonium chloride, carrageenan or locust tree fresh kidney beans；

The sweetener is in saccharin sodium, Sucralose, xylitol, honey element, Aspartame, stevioside or mogroside One or more；

The essence is selected from one or more of vanilla, spearmint, minty note or Chinese ilex peppermint；

The preservative is selected from benzoic acid and its esters, sorbic acid and one or more of its esters or parabens；

The appearance modifying agents are selected from titanium dioxide, food coloring, food color lake or one or more of the particle that cleans the teeth；

The solvent is selected from deionized water.

8. toothpaste according to claim 5, which is characterized in that the toothpaste further includes a kind of following ingredient：

9. a kind of mouthwash, which is characterized in that include the component of following parts by weight：

Active component：

Rosemary leaf extract 0.05-5 parts by weight；

Leaf of Mentha piperita extract 0.1-2.5 parts by weight；

Medicine extracts of Salvia officinalis leaves 0.06-4 parts by weight；

Auxiliary material：

10. mouthwash according to claim 9, which is characterized in that the solvent is selected from deionized water；

The moisturizer is selected from one or more of sorb (sugar) alcohol, propylene glycol, glycerine, polyethylene glycol-8；

The surfactant is selected from poloxamer188, lauryl sodium sulfate, sodium lauroyl sarcosine, cocounut oil acyl methyl ox One or more of sodium sulfonate；

The thickener is selected from one or more of cellulose, card wave, carragheen；

The food flavor is selected from cloves, Chinese cassia tree perfume, fragrance of osmanthus, peppermint oil, vanilla, spearmint, minty note, Chinese ilex peppermint One or more of；

The colorant is selected from one or more of green, blue, red；

It is furthermore preferred that above-mentioned mouthwash further includes following ingredient：