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CN108042384B - A composition with oral cleaning and treating effects - Google Patents

A composition with oral cleaning and treating effects Download PDF

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Publication number
CN108042384B
CN108042384B CN201810014412.9A CN201810014412A CN108042384B CN 108042384 B CN108042384 B CN 108042384B CN 201810014412 A CN201810014412 A CN 201810014412A CN 108042384 B CN108042384 B CN 108042384B
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composition
parts
oral
toothpaste
following components
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CN108042384A (en
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郭智华
徐双华
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Holwray Pharmaceutical China Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions
    • A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18

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  • Oral & Maxillofacial Surgery (AREA)
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Abstract

The invention relates to a composition with oral cleaning and treatment effects, which comprises the following components in parts by weight: 0.0001-2 parts of sodium azulene sulfonate, 0.1-15 parts of scutellaria baicalensis extract and 0.1-25 parts of dandelion extract. The composition can be further made into toothpaste or mouthwash. The composition provided by the invention fully exerts the synergistic interaction effect among the components by utilizing different medicinal mechanisms of the components, so that the obtained composition can relieve gingival inflammation, accelerate the healing of oral ulcer and eliminate helicobacter pylori in oral cavity.

Description

A composition with oral cleaning and treating effects
Technical Field
The invention belongs to the technical field of daily chemical products, and particularly relates to a composition with oral cleaning and treatment effects.
Background
National epidemiological sampling surveys have shown that 70.87-92.43% of the adult population suffers from varying degrees of periodontitis. Periodontitis is a variety of diseases that occur in periodontal supporting tissues (cementum, alveolar bone, gingiva, periodontal ligament). Firstly, the gum is red and swollen, the permeability of the gum mucous membrane is enhanced, the gum mucous membrane develops into effusion, the probe is easy to bleed after being touched, if the treatment is not carried out in time, the gum atrophy, alveolar bone absorption, periodontal pocket formation, tooth looseness and displacement can occur, periodontal thickening and oral cavity peculiar smell can be caused, and finally, the tooth is dropped or pulled out. Periodontal disease is therefore the leading cause of tooth loss in adults.
The oral ulcer is the disease with the highest incidence rate in oral mucosa diseases, can be caused by accident under the conditions of common cold, dyspepsia, mental stress, depression and the like, and can be caused at any part of the mucosa, such as lips, cheeks, tongue margin and the like. The disease has the characteristics of periodicity, recurrence, self-limitation and the like.
Meanwhile, patients with gingival inflammation and oral ulcer provide places for survival of helicobacter pylori, the helicobacter pylori generally spreads in mouth, and after the helicobacter pylori is infected, the helicobacter pylori generally exists in dental plaque, oral mucosa, gum pocket and other parts, so that after the oral cavity is infected, odorous compounds can be directly generated to cause halitosis. After swallowing food or saliva into the stomach, chronic gastritis and gastric ulcer gradually develop.
Therefore, the use of ordinary oral preparations is far from sufficient, and in order to prevent gingival inflammation, oral ulcer and oral infection with helicobacter pylori, it is necessary to develop an oral product which not only cleans the oral cavity but also reduces gingival inflammation, accelerates the healing of oral ulcer, and eliminates helicobacter pylori in the oral cavity.
Disclosure of Invention
Based on the above background, the present invention is directed to a composition with oral cleaning and treatment effects, comprising the following components in parts by weight:
0.0001-2 parts of sodium azulene sulfonate
0.1-15 parts of scutellaria baicalensis extract
0.1-25 parts of dandelion extract;
preferably, the composition comprises the following components in parts by weight:
0.05-1 part of sodium azulene sulfonate
1.5-9 parts of scutellaria baicalensis extract
1-12 parts of dandelion extract.
The sodium azulene sulfonate is prepared by modifying the molecular structure of guaiazulene. The sodium azulene sulfonate has excellent effects of resisting inflammation, bacteria and allergy and promoting tissue regeneration, can promote healing of burn and scald wound surfaces and ulcer wound surfaces and granulation regeneration, has multiple effects of heat prevention, radiation protection, chapping prevention and the like, can be used for treating various diseases, has high safety, is widely applied to various pharmaceutical preparations, and particularly has remarkable effect on treatment and prevention of skin and oral diseases.
The scutellaria baicalensis extract comprises flavonoid compounds; wherein the total amount of baicalin, wogonoside, baicalein and wogonin in the brass compounds is not less than 85%; the Scutellariae radix extract can be used for treating damp heat, summer heat, chest distress, nausea, dampness, heat, abdominal fullness, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, blood heat, epistaxis, carbuncle, swelling, and skin sore.
The scutellaria baicalensis extract adopted by the invention is an alcohol extract or an aqueous extract of scutellaria baicalensis.
The dandelion extract comprises Taraxasterol (Taraxasterol), Choline (Choline), Inulin (Inulin), Pectin (Pectin), taraxolol (taraxolol), Stigmasterol (Stigmasterol), β -resinol (β -Amyrin), β -Sitosterol (β -Sitosterol), taraxerol (taraxolol), Taraxacin (Taraxacin), vitamin A, vitamin B and microorganism C, has the effects of clearing away heat and toxic materials, removing swellings and dissipating binds, and inducing diuresis for treating stranguria, and has strong killing effect on staphylococcus aureus drug-resistant strains and hemolytic streptococcus.
The dandelion extract adopted by the invention is an alcohol extract or a water extract of dandelion.
The sodium azulene sulfonate, the scutellaria baicalensis extract and the dandelion extract are mutually compatible and act synergistically; on the basis, the proportion ratio is further explored, and the obtained composition effect is obviously improved.
The invention further provides that the composition also comprises one or more of honeysuckle, mint, rhubarb, areca nut, liquorice, purslane, astragalus, phellodendron, myrrh, purple daisy, sage, angelica, peony, raspberry, chastetree flower, forsythia, zedoary, cyperus rotundus, atractylodes, evodia, bitter orange, salvia and pseudo-ginseng powder.
When the composition further comprises honeysuckle; the composition further comprises 0.1-24 parts by weight of honeysuckle.
When the composition further comprises herba Menthae, radix et rhizoma Rhei, Arecae semen, and Glycyrrhrizae radix; the composition also comprises the following components in parts by weight:
Figure BDA0001541434440000031
the invention provides a preferable scheme, and the composition comprises the following components in parts by weight:
Figure BDA0001541434440000032
when the composition further comprises herba Portulacae, radix astragali, cortex Phellodendri, Myrrha, purple daisy, herba Salvia officinalis, radix Angelicae sinensis, radix Paeoniae, fructus Rubi, flos Viticis, fructus forsythiae, Curcumae rhizoma, rhizoma Cyperi, Atractylodis rhizoma, fructus evodiae, fructus Aurantii, Saviae Miltiorrhizae radix, and Notoginseng radix powder; the composition also comprises the following components in parts by weight:
Figure BDA0001541434440000041
the invention provides a preferable scheme, and the composition comprises the following components in parts by weight:
Figure BDA0001541434440000042
Figure BDA0001541434440000051
a second object of the present invention is to provide a toothpaste comprising the composition of any of the above;
preferably, the toothpaste further comprises a solvent and a functional auxiliary agent, wherein the functional auxiliary agent is selected from two or more of an abrasive agent, a humectant, a foaming agent, a thickening agent, a sweetening agent, an essence, a preservative and an appearance modifier;
more preferably, the functional assistant consists of the following components:
Figure BDA0001541434440000061
preferably, the abrasive is selected from one or more of silicon dioxide, hydrated calcium hydrophosphate, anhydrous calcium hydrophosphate, calcium carbonate, aluminum hydroxide and calcium pyrophosphate;
the humectant is selected from one or more of sorbitol, glycerol, propylene glycol, polyethylene glycol-8 and butanediol;
the foaming agent is selected from one or more of sodium dodecyl sulfate, sodium lauroyl sarcosinate, sodium cocoyl glycinate, sodium acyl glutamate and sodium cocoyl methyl taurate;
the thickening agent is selected from one or more of cellulose and derivatives thereof, guar gum, sodium alginate, xanthan gum, guar gum hydroxypropyl trimethyl ammonium chloride, carrageenan and locust bean;
the sweetener is selected from one or more of saccharin sodium, sucralose, xylitol, sodium cyclamate, aspartame, stevioside and mogroside;
the essence is selected from one or more of vanilla essence, spearmint, mint and wintergreen mint;
the preservative is selected from one or more of benzoic acid and salts thereof, sorbic acid and salts thereof and parabens;
the appearance modifier is one or more selected from titanium dioxide, food pigment, food color lake and tooth cleaning particle.
The invention provides a preferable scheme, and the toothpaste comprises the following components in 100 parts:
Figure BDA0001541434440000071
Figure BDA0001541434440000081
a third object of the present invention is to provide a mouthwash comprising the composition of any of the above;
preferably, the mouthwash further comprises a solvent and a functional aid, wherein the functional aid is two or more selected from a humectant, a surfactant, a thickener, ethanol, a flavoring essence and a coloring agent;
more preferably, the functional assistant consists of the following components:
Figure BDA0001541434440000082
the humectant is selected from one or more of sorbitol, propylene glycol, glycerol and polyethylene glycol-8;
the surfactant is selected from one or more of poloxamer 407, sodium lauryl sulfate, sodium lauroyl sarcosinate and sodium cocoyl methyl taurate;
the thickening agent is selected from one or more of cellulose, carbomer and carrageenan;
the edible essence is selected from one or more of flos Caryophylli, cortex Cinnamomi, flos Osmanthi Fragrantis, oleum Menthae Dementholatum, herb Hierochloes Adoratae essence, herba Menthae Rotundifoliae, herba Menthae Haplocalycis, and herba Menthae Dementholati;
the colorant is selected from one or more of green, blue and red.
The invention provides a preferable scheme, and the mouthwash comprises the following components in 100 parts:
Figure BDA0001541434440000091
Figure BDA0001541434440000101
the composition provided by the invention fully exerts the synergistic interaction effect among the components by utilizing different medicinal mechanisms of the components, so that the obtained composition can relieve gingival inflammation, accelerate the healing of oral ulcer and eliminate helicobacter pylori in oral cavity.
Detailed Description
The present invention is further explained by the following detailed description, it should be noted that, for those skilled in the art, a plurality of modifications and amendments can be made without departing from the principle of the present invention, and these modifications and amendments should also be regarded as the protection scope of the present invention.
Examples 1 to 6
Embodiments 1 to 6 provide a composition, comprising, in parts by weight:
TABLE 1
Figure BDA0001541434440000102
Examples 7 to 9
Examples 7-9 provide a composition comprising, in parts by weight:
TABLE 2
Figure BDA0001541434440000111
Examples 10 to 14
Examples 10-14 provide a composition, comprising, in parts by weight:
TABLE 3
Figure BDA0001541434440000112
Figure BDA0001541434440000121
Examples 15 to 20
In order to illustrate the advantages of the toothpaste, the toothpaste prepared by the conventional method in the embodiments 1-6 comprises the following components in 100 parts:
TABLE 4
Figure BDA0001541434440000122
Figure BDA0001541434440000131
Examples 21 to 23
In order to illustrate the advantages of the invention, the toothpaste prepared by the conventional method in the examples 7-9 comprises the following components in 100 parts:
TABLE 5
Figure BDA0001541434440000132
Figure BDA0001541434440000141
The preparation method comprises the following steps: the toothpaste is prepared by uniformly mixing the raw materials according to a conventional method.
Examples 24 to 28
In order to illustrate the advantages of the invention, the toothpaste prepared by the conventional method in the embodiment 9-13 comprises the following components in 100 parts:
TABLE 6
Figure BDA0001541434440000142
Figure BDA0001541434440000151
Figure BDA0001541434440000161
The preparation method comprises the following steps: the toothpaste is prepared by uniformly mixing the raw materials according to a conventional method.
Examples 29 to 31
Embodiments 29 to 31 provide a mouthwash composition, comprising, in 100 parts, the following components:
TABLE 7
Figure BDA0001541434440000162
The preparation method comprises the following steps: the raw materials are uniformly mixed according to a conventional method to prepare the mouthwash.
Examples 32 to 34
Embodiments 32 to 34 provide a mouthwash composition, comprising, in 100 parts, the following components:
TABLE 8
Figure BDA0001541434440000171
The preparation method comprises the following steps: the raw materials are uniformly mixed according to a conventional method to prepare the mouthwash.
Examples 35 to 39
Embodiments 33-39 provide a mouthwash composition, comprising, in 100 parts, the following components:
TABLE 9
Figure BDA0001541434440000172
Figure BDA0001541434440000181
Figure BDA0001541434440000191
The preparation method comprises the following steps: the raw materials are uniformly mixed according to a conventional method to prepare the mouthwash.
Comparative examples 1 to 3
Comparative examples 1 to 3 provide a composition, wherein other raw materials and specific gravity are unchanged, cetylpyridinium chloride (as a surfactant, which inhibits and kills bacteria by reducing surface tension, treats periodontal diseases, controls bacterial plaque, eliminates oral candida, kills oral odor causing bacteria in oral cavity of an oral halitosis patient, and can inhibit growth of oral helicobacter pylori for a long time under the condition of good oral cavity condition) is used to replace sodium azulene sulfonate in examples 1 to 3, and the composition comprises the following components in parts by weight:
watch 10
Figure BDA0001541434440000192
Comparative examples 4 to 6
Comparative examples 4 to 6 provide a composition comprising, in parts by weight:
TABLE 11
Figure BDA0001541434440000193
Figure BDA0001541434440000201
Comparative examples 7 to 10
Comparative examples 7 to 10 provide a composition comprising, in parts by weight:
TABLE 12
Figure BDA0001541434440000202
Figure BDA0001541434440000211
Comparative examples 11 to 13
Comparative examples 11 to 13 provide a toothpaste composition comprising, in parts by weight:
watch 13
Figure BDA0001541434440000212
Comparative examples 14 to 16
Comparative examples 14-16 provide a toothpaste composition comprising, in parts by weight:
TABLE 14
Figure BDA0001541434440000221
Comparative examples 17 to 20
Comparative examples 17 to 20 provide a toothpaste composition comprising, in parts by weight:
watch 15
Figure BDA0001541434440000231
Figure BDA0001541434440000241
Test example 1
Examples 15 to 20 were compared with comparative examples 11 to 13.
1. Human body test (for gingivitis treatment)
Volunteers with gingival swelling and bleeding symptoms are selected to participate in the human body trial test of the toothpaste, the test samples are randomly divided into 25 persons in each group, the toothpaste in the embodiment and the comparative example is used for each group, the group is used once in the morning and at night every day, and the gingivitis treatment effect is investigated after four weeks.
The criteria for therapeutic effect are as follows:
and (3) curing: the subjective symptoms of the patient disappear, the gingival inflammation disappears completely, the damaged gingival connective tissue can see new collagen fibers, and the function, color, shape and quality of the gingiva are all recovered to be normal;
improvement: the patient's gingiva and gingival papilla are reddish, have slight edema, hyperemia, and are brittle, and have little punctate bleeding when the gingival sulcus is touched by a blunt round probe;
and (4) invalidation: the patient's gingiva still had swelling and pain, and bleeding was seen in probing without improvement of symptoms and signs.
The total effective rate of treatment is × 100% (cure + improvement)/total number of cases.
The results are given in the following table:
TABLE 16
Figure BDA0001541434440000242
Figure BDA0001541434440000251
2. Human body test (curative effect on canker sore)
Selecting more than 1 year with the history of oral ulcer; recurrent attacks, at least once a month; in the attack stage, and the attack time is within 48 hours; meanwhile, patients accompanied with halitosis participate in the test of the treatment effect of the toothpaste on the oral ulcer, the treatment effect is randomly divided into groups according to the number of test samples, 25 persons are respectively used in each group, the toothpaste in the embodiment and the comparative example is respectively used in the morning and the evening of each day, and the helicobacter pylori clearance in the oral cavity, the halitosis phenomenon disappearance rate and the treatment effect of the oral ulcer are detected after 8 weeks.
Evaluation indexes of oral ulcer treatment effect:
total pause time (days) (interval, I): evaluation period no sum of ulcer time.
Total ulcer number (number, N): the sum of the number of ulcer recurrences over the evaluation period.
Grading evaluation indexes:
I1-Total pause time extension (t test, P <0.05)
I0-Total pause time unchanged (t test, P >0.05)
N1-Total ulcer number decreased (t test, P <0.05)
N1-No change in Total ulcer number (t test, P >0.05)
Evaluation criteria:
and (3) healing: the oral ulcer can be stopped and recurred for more than one year
The effect is shown: I1N1
The method has the following advantages: I0N1 or I1N0
And (4) invalidation: I0N0
Effective rate (cure + significant effect + effective)/total number × 100%.
The results are given in the following table:
TABLE 17
Figure BDA0001541434440000261
The above results show that the combined use of sodium azulene sulfonate, scutellaria baicalensis extract and dandelion extract has significantly better effect than the combined use of cetylpyridinium chloride, scutellaria baicalensis extract and dandelion extract under the condition of the same amount of effective components.
Test example 2
Examples 21 to 23 were compared with comparative examples 14 to 16 in the same manner as in test example 1.
1. Human test (therapeutic effect on gingivitis), the results are as follows:
watch 18
Figure BDA0001541434440000262
Figure BDA0001541434440000271
2. Human tests (effect of treatment on oral ulcers) the results were as follows:
watch 19
Figure BDA0001541434440000272
The above results show that the effect of the composition can be further improved by adding one or more of honeysuckle, mint, rhubarb, areca and liquorice.
Test example 3
Examples 24 to 28 were compared with comparative examples 17 to 20 in the same manner as in test example 1.
1. Human test (therapeutic effect on gingivitis), the results are as follows:
watch 20
Figure BDA0001541434440000273
Figure BDA0001541434440000281
2. Human tests (effect of treatment on oral ulcers) the results were as follows:
TABLE 21
Figure BDA0001541434440000282
The above results show that the effect of the composition can be further improved by adding purslane, astragalus, phellodendron, myrrh, marguerite, sage, angelica, peony, raspberry, chaste tree flower, forsythia, zedoary, cyperus rotundus, atractylodes, evodia, bitter orange, salvia and pseudo-ginseng powder.
Although the invention has been described in detail hereinabove by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that many modifications and improvements can be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims (4)

1. The toothpaste is characterized by comprising the following active ingredients in parts by weight:
Figure FDA0002386809580000011
Figure FDA0002386809580000021
2. the toothpaste according to claim 1, wherein the toothpaste further comprises a solvent and a functional aid selected from two or more of an abrasive agent, a humectant, a foaming agent, a thickener, a sweetener, a flavor, a preservative, and an appearance modifier.
3. The toothpaste according to claim 2, wherein the functional adjuvant consists of:
Figure FDA0002386809580000022
4. the toothpaste according to any one of claims 1 to 3, comprising the following components in 100 parts:
Figure FDA0002386809580000023
Figure FDA0002386809580000031
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CN112022775A (en) * 2020-10-13 2020-12-04 福州比格艾普科技有限公司 Oral care product for resisting helicobacter pylori
CN112716854B (en) * 2021-01-27 2022-12-13 新乡博凯生物技术有限公司 Traditional Chinese medicine toothpaste and preparation method thereof
CN113230165B (en) * 2021-04-02 2023-03-17 北京圣永制药有限公司 A collutory containing marrubium vulgare extract with antiinflammatory and antibacterial effects
CN114652669B (en) * 2022-04-22 2023-03-28 江苏雪豹日化有限公司 Toothpaste with effects of clearing away fire and resisting allergy and preparation method thereof

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CN106937925A (en) * 2017-03-03 2017-07-11 江苏康缘药业股份有限公司 A kind of compound traditional Chinese medicine composite and toothpaste containing the compound traditional Chinese medicine composite and preparation method thereof
CN107468878A (en) * 2017-10-13 2017-12-15 佛山科学技术学院 A kind of Chinese medicine composition for treating canker sore

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