CN106110075A - A kind of pharmaceutical composition of set a broken bone and preparation method thereof - Google Patents
A kind of pharmaceutical composition of set a broken bone and preparation method thereof Download PDFInfo
- Publication number
- CN106110075A CN106110075A CN201610679935.6A CN201610679935A CN106110075A CN 106110075 A CN106110075 A CN 106110075A CN 201610679935 A CN201610679935 A CN 201610679935A CN 106110075 A CN106110075 A CN 106110075A
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- CN
- China
- Prior art keywords
- pharmaceutical composition
- parts
- radix
- fine powder
- standby
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Classifications
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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Abstract
The present invention relates to pharmaceutical composition of a kind of set a broken bone and preparation method thereof, this pharmaceutical composition is made up of the medicine of following weight portion: Flos Buddlejae, Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa, Flos Carthami, Radix Glycyrrhizae, pass through alcohol extraction, the techniques such as soak by water are made, by the medicine of the present invention observation to 1068 example bone injury clinical efficacies, fracture caused by primary treatment traumatic injury, osteodynia, congestion, dislocation, Should pain, muscle sprain, the folding injury of tendon and muscle is damaged has significant curative effect, total effective rate averagely reaches 96%, and do not find untoward reaction and toxic and side effects, illustrate that medicine composite for curing patient with bone fracture aspect of the present invention is evident in efficacy, there is good promotional value.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to pharmaceutical composition of a kind of set a broken bone and preparation method thereof.
Background technology
Bone injury, particularly fracture are a kind of common and frequently-occurring disease, can betide each age level.Chinese traditional treatment bone injury with
" QI and blood regulating " occupies an leading position, and focuses on " blood ".Just have in "Nei Jing" ' blood then passages through which vital energy circulates alive is popular, the multiple negative and positive of battalion,
Powerful muscle and bone, joint profit clearly '.Ancient Chinese medicine doctor medication is many to be set about from " invigorating blood circulation ", propose ' damage a disease, specially from blood opinion, treatment by oral administration of medicines it
Method, it is necessary to blood circulation promoting and blood stasis dispelling as elder generation, blood live then the stasis of blood can not go, the stasis of blood does not goes then bone not connect '.Bone injury all various degrees
Swell and ache, the fracture blood in bone marrow and body fluid and soft tissue blood capillary breakage are exuded in tissue later blood, the stasis of blood
Amass at fracture and about, be allowed to that livid purple swelling occurs, ischemia, anoxia, the healing of impact fracture, such as, upper limb elbow
Portion's fracture influences whether hands, makes hands obvious swelling occur；Thigh or internal fixation of knee fractures influence whether shank or foot, and fracture itself is again
Raw ability is strong, and the purpose of medication is to aid in reducing swelling and alleviating pain, so controlling fracture medicine used, is blood circulation promoting and blood stasis dispelling mostly.Mesh
Before, the medicine for the treatment of fracture is a lot, and existing Chinese medicine also has Western medicine, has medicine for external use, also has innerlich anwenden, but contract the most further
Low doses, alleviates the misery of the wounded, is a current difficult problem.
The present inventor, in order to solve the problems referred to above, have developed a kind of new drug.
Summary of the invention
It is an object of the invention to provide the pharmaceutical composition of a kind of set a broken bone.
It is a further object of the present invention to provide the preparation method of the pharmaceutical composition of a kind of set a broken bone.
The present invention provides the pharmaceutical composition of a kind of set a broken bone, and this pharmaceutical composition is by the medicine system of following weight portion
Become: Flos Buddlejae 5-15 part, Semen Coicis 15-45 part, Herba Dianthi 10-30 part, Corallium Japonicum Kishinouye 10-35 part, Fructus Ligustri Lucidi 20-40 part, Radix Cynanchi Atrati 10-30
Part, Radix Polygalae 10-30 part, Herba Schizonepetae 15-35 part, Fructus Gardeniae 15-35 part, Tufa 10-30 part, Flos Carthami 10-30 part, Radix Glycyrrhizae 15-30
Part.
Preferably, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Flos Buddlejae 7-13 part, Semen Coicis
Core 18-42 part, Herba Dianthi 12-28 part, Corallium Japonicum Kishinouye 12-32 part, Fructus Ligustri Lucidi 22-38 part, Radix Cynanchi Atrati 12-28 part, Radix Polygalae 12-28 part, Herba Schizonepetae
Fringe 18-32 part, Fructus Gardeniae 18-32 part, Tufa 12-28 part, Flos Carthami 12-28 part, Radix Glycyrrhizae 18-28 part.
It is further preferred that pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Flos Buddlejae 8-12
Part, Semen Coicis 22-38 part, Herba Dianthi 15-25 part, Corallium Japonicum Kishinouye 15-28 part, Fructus Ligustri Lucidi 25-35 part, Radix Cynanchi Atrati 15-25 part, Radix Polygalae 15-25
Part, Herba Schizonepetae 20-30 part, Fructus Gardeniae 20-30 part, Tufa 15-25 part, Flos Carthami 15-25 part, Radix Glycyrrhizae 20-26 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Flos Buddlejae 9-
11 parts, Semen Coicis 25-35 part, Herba Dianthi 18-22 part, Corallium Japonicum Kishinouye 18-25 part, Fructus Ligustri Lucidi 28-32 part, Radix Cynanchi Atrati 18-23 part, Radix Polygalae 18-
23 parts, Herba Schizonepetae 22-28 part, Fructus Gardeniae 22-28 part, Tufa 17-23 part, Flos Carthami 17-23 part, Radix Glycyrrhizae 22-24 part.
Further preferred, pharmaceutical composition of the present invention is made up of the medicine of following weight portion: Flos Buddlejae 10
Part, Semen Coicis 30 parts, Herba Dianthi 20 parts, 22 parts of Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi 30 parts, Radix Cynanchi Atrati 20 parts, Radix Polygalae 20 parts, Herba Schizonepetae 25 parts, Fructus Gardeniae
25 parts, Tufa 20 parts, 20 parts of Flos Carthami, 23 parts of Radix Glycyrrhizae.
Pharmaceutical composition of the present invention is possibly together with pharmaceutically acceptable carrier or diluent.
Pharmaceutical composition of the present invention is liquid preparation；Described liquid preparation spray.
Pharmaceutical composition preparation method of the present invention comprises the following steps: by Flos Buddlejae, Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye,
Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa, Flos Carthami, Radix Glycyrrhizae pulverize and sieve, with pharmaceutically acceptable carrier or
Diluent mix homogeneously, is prepared as preparation.
Pharmaceutical composition preparation method of the present invention comprises the following steps:
1) Flos Buddlejae adds 2-4 times amount vinegar soak 2-5 hour, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 2-5 times amount water
Decoct 1-3 hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the second of 2-5 times amount 75%
Alcohol soaks 2-5 hour, filters, filtrate concentrate drying, is ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, pharmaceutically acceptable carrier or diluent mix homogeneously are added, system
Become preparation.
Preferably, pharmaceutical composition preparation method of the present invention comprises the following steps:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 3 times amount 75%
3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, pharmaceutically acceptable carrier or diluent mix homogeneously are added, system
Become preparation.
Described parts by weight can be unit of weight known to the field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier that pharmaceutical field is conventional, selected from filler,
One or more in binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or Portugal
Grape sugar etc.；
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.；
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low substituted hydroxy-propyl fiber
Element or cross-linking sodium carboxymethyl cellulose；
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or stearic acid
Magnesium；
Described surfactant is selected from dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fat
Fat acid Pyrusussuriensis is smooth or Polysorbate (tween) etc.；
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The method have the advantages that
By the medicine of the present invention observation to 1068 example bone injury clinical efficacies, fracture caused by primary treatment traumatic injury,
Osteodynia, congestion, dislocation, Should pain, muscle sprain, the folding injury of tendon and muscle is damaged has significant curative effect, and total effective rate averagely reaches
96%, and do not find untoward reaction and toxic and side effects, illustrate that medicine composite for curing patient with bone fracture aspect curative effect of the present invention shows
Write, there is good promotional value.
Detailed description of the invention
Following example are used for illustrating the present invention, but are not limited to the scope of the present invention.
Embodiment 1
Prescription: Flos Buddlejae 5g, Semen Coicis 15g, Herba Dianthi 10g, Corallium Japonicum Kishinouye 10g, Fructus Ligustri Lucidi 20g, Radix Cynanchi Atrati 10g, Radix Polygalae 10g, chaste tree
Mustard fringe 15g, Fructus Gardeniae 15g, Tufa 10g, Flos Carthami 10g, Radix Glycyrrhizae 15g.
Preparation method:
1) Flos Buddlejae adds 2 times amount vinegar soak 2 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 2 times amount decoctings
Boil 1 hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 2 times amount 75%
2 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 2
Prescription: Flos Buddlejae 15g, Semen Coicis 45g, Herba Dianthi 30g, Corallium Japonicum Kishinouye 35g, Fructus Ligustri Lucidi 40g, Radix Cynanchi Atrati 30g, Radix Polygalae 30g, chaste tree
Mustard fringe 35g, Fructus Gardeniae 35g, Tufa 30g, Flos Carthami 30g, Radix Glycyrrhizae 30g.
Preparation method:
1) Flos Buddlejae adds 4 times amount vinegar soak 5 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 5 times amount decoctings
Boil 3 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 5 times amount 75%
5 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 3
Prescription: Flos Buddlejae 7g, Semen Coicis 18g, Herba Dianthi 12g, Corallium Japonicum Kishinouye 12g, Fructus Ligustri Lucidi 22g, Radix Cynanchi Atrati 12g, Radix Polygalae 12g, chaste tree
Mustard fringe 18g, Fructus Gardeniae 18g, Tufa 12g, Flos Carthami 12g, Radix Glycyrrhizae 18g.
Preparation method:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 3 times amount 75%
2-5 hour, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 4
Prescription: Flos Buddlejae 13g, Semen Coicis 42g, Herba Dianthi 28g, Corallium Japonicum Kishinouye 32g, Fructus Ligustri Lucidi 38g, Radix Cynanchi Atrati 28g, Radix Polygalae 28g, chaste tree
Mustard fringe 32g, Fructus Gardeniae 32g, Tufa 28g, Flos Carthami 28g, Radix Glycyrrhizae 28g.
Preparation method:
1) Flos Buddlejae adds 3 times amount vinegar soak 4 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 4 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 4 times amount 75%
4 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 5
Prescription: Flos Buddlejae 8g, Semen Coicis 22g, Herba Dianthi 15g, Corallium Japonicum Kishinouye 15g, Fructus Ligustri Lucidi 25g, Radix Cynanchi Atrati 15g, Radix Polygalae 15g, chaste tree
Mustard fringe 20g, Fructus Gardeniae 20g, Tufa 15g, Flos Carthami 15g, Radix Glycyrrhizae 20g.
Preparation method:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 3 times amount 75%
3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 6
Prescription: Flos Buddlejae 12g, Semen Coicis 38g, Herba Dianthi 25g, Corallium Japonicum Kishinouye 28g, Fructus Ligustri Lucidi 35g, Radix Cynanchi Atrati 25g, Radix Polygalae 25g, chaste tree
Mustard fringe 30g, Fructus Gardeniae 30g, Tufa 25g, Flos Carthami 25g, Radix Glycyrrhizae 26g.
Preparation method:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 3 times amount 75%
3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 7
Prescription: Flos Buddlejae 9g, Semen Coicis 25g, Herba Dianthi 18g, Corallium Japonicum Kishinouye 18g, Fructus Ligustri Lucidi 28g, Radix Cynanchi Atrati 18g, Radix Polygalae 18g, chaste tree
Mustard fringe 22g, Fructus Gardeniae 22g, Tufa 17g, Flos Carthami 17g, Radix Glycyrrhizae 22g.
Preparation method:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 3 times amount 75%
3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 8
Prescription: Flos Buddlejae 11g, Semen Coicis 35g, Herba Dianthi 22g, Corallium Japonicum Kishinouye 25g, Fructus Ligustri Lucidi 32g, Radix Cynanchi Atrati 23g, Radix Polygalae 23g, chaste tree
Mustard fringe 28g, Fructus Gardeniae 28g, Tufa 23g, Flos Carthami 23g, Radix Glycyrrhizae 24g.
Preparation method:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 3 times amount 75%
3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Embodiment 9
Prescription: Flos Buddlejae 10g, Semen Coicis 30g, Herba Dianthi 20g, Corallium Japonicum Kishinouye 22g, Fructus Ligustri Lucidi 30g, Radix Cynanchi Atrati 20g, Radix Polygalae 20g, chaste tree
Mustard fringe 25g, Fructus Gardeniae 25g, Tufa 20g, Flos Carthami 20g, Radix Glycyrrhizae 23g.
Preparation method:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount decoctings
Boil 2 hours, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the soak with ethanol of 3 times amount 75%
3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merging
Impregnation liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
Herein below is the drug effect carrying out the pharmaceutical composition of the set a broken bone that above-described embodiment provides and toxicological test
Research:
One, treatment is by stages
The present invention is for the treatment of bone injury after open fracture, and injured limb congestive edema is serious in early days, locally red heat pain, wound
Stomatorrhagia, treats and preferably stops blooding, blood stasis dispelling, heat-clearing and toxic substances removing, reducing swelling and alleviating pain.And the medicine of the present invention has this function, after one week
The skin and flesh that is pierced for the treatment of can heal, make open fracture become closed fracture.
Mid-term: injured limb local red heat swells and ache and alleviates, and knochenbruch starts healing, " blood stasis removing hemopoietic gas, the stasis of blood goes the life of new bone "
Basic principle, treats and preferably regulates the flow of vital energy, and removing heat from blood, promoting the circulation of blood, blood circulation and promoting silt medicine, the present invention is played a role by skin, makes blood capillary
Expansion, accelerates blood circulation, strengthens regional flow's perfusion, and the dredging muscle arteries and veins stasis of blood is stagnant, reduces intraosseous pressure, improves microcirculation, accelerates
New bone growth, promotes that sequestrum absorbs, removes the acidic secretion thing that the stasis of blood is long-pending, increase local organization oxonium ion and the confession of nutrition
Give, recover normal blood fortune, jointly play and " remove and dislike the stasis of blood, qi and blood circulation, eliminating blood stasis to promote regeneration of blood, promote knochenbruch to heal rapidly, promote bone
Crust grows.
In the later stage: knochenbruch healing is the firmest, joint motion owes profit, suffers from flesh muscular strength weakness, treats preferably and channels, strengthening bone and muscle,
Medicine of the present invention is played a role by skin, blood circulation promoting, recovers neuromuscular function, promotes cell fast-growth, makes
Bone injury is quickly fully recovered.
Two, the present composition observation of curative effect to bone injury (fracture)
1, fracture clinical criteria fracture local symptom
1. swelling and ecchymosis；
2. pain and tenderness is ached；
3. deformity and movement of false joint；
4. bony crepitus；
5. function completely loses.
Open fracture: naked eyes are it can be seen that the dermatorrhagia worn by bony spur, dyskinesia, and X sheet observes fractures
There is sclerotin fracture and fracture site gap in position.
Closed fracture: skin is without breakage, and X sheet is it can be seen that between the fracture of fracture site generation sclerotin and fracture site
Gap.
Pharmaceutical composition of the present invention carries out contrast treatment to opening fracture case and closed fracture patient, and test group makes
With the medicine composite for curing of the embodiment of the present invention 1, matched group selects existing pharmaceutical methods to treat, thus to the present invention's
Curative effect is analyzed, and treatment healing is shown as standard with X sheet.
2, curative effect judging standard
1. recovery from illness: the symptoms such as swelling pain are completely eliminated, and have a large amount of callus formation, functional rehabilitation.
The most effective: the symptoms such as swelling pain alleviate, there is callus formation, fracture line obscures.
The most invalid: limb pain, swelling symptom does not alleviate.
3, therapeutic process
After fracture site manual reduction reduction is good, the embodiment of the present invention 1 being sprayed on fracture site, every 5 hours spray medicines are once.
Matched group is illustrated to carry out by art methods.
4, treatment exploration fracture 60 example result tables
5, closed fracture 60 example result table
By above two groups of comparisons, the embodiment of the present invention 1 is better than existing method, can Shorten the Treatment Process.Two groups of curative effect ratios
Relatively, through statistical procedures, P ＞ 0.05, experimental group healing time, ratio matched group union of fracture, the fastest 1/2nd.
Other bone injury disease criterion of therapeutical effect judges:
1, dislocating: the dislocation that improvement reduction is good, medication can be subsided a swelling after 1 day completely, only hypodynia.
Recovery from illness: can be freely movable after 2 days, returns to one's perfect health.
2, Should pain: take a turn for the better, medication swell and ache one day after big portion eliminate, only mild pain；
Recovery from illness: after 2 days, swell and ache and be completely eliminated.
The medicine of the present invention observation such as following table to 1057 example bone injury clinical efficacies:
The present invention Ureteral Calculus to bone injury, total effective rate averagely reaches 96%.
Model case is as follows:
Case one: Wang, man, 18 years old, left lower end of radius open fracture, after manual reduction, sprays the embodiment of the present invention 1 medicine
Compositions, 5 hours/time, pain relief after 24 hours, have started to detumescence, after 8 days, be pierced is healed by meat, has callus
Being formed, after 25 days, X sheet shows a large amount of callus formation, functional rehabilitation.
Case two: field, female, 40 years old, left hand humeral fracture, after manual reduction, sprays the embodiment of the present invention 2 drug regimen
Thing, 5 hours/time, pain relief after 18 hours, detumescence substantially, has a large amount of callus formation after 1 week, fracture site swelling, pain are complete
Full elimination, has a large amount of callus formation after 20 days, functional rehabilitation is fully recovered.
Case three: Xiao, field, 58 years old, right Tibio-fibula fracture, after manual reduction, sprays the embodiment of the present invention 3 medicine
Compositions, 5 hours/time, pain relief after 24 hours, the skin and flesh being pierced after 18 days heals, and swelling substantially eliminates, and has fuzzy
Callus formation, after 25 days, fracture site swelling pain is completely eliminated, and has a large amount of callus formation, functional rehabilitation after 42 days.
Case four: shut out certain, female, 39 years old, left foot shank closed fracture during work, after manual reduction, spray was the present invention implement
Example 4 pharmaceutical composition, 5 hours/time, pain relief after 20 hours, pain after 1 week, swelling substantially eliminates, swelling pain after 12 days
It is completely eliminated, has a large amount of callus formation, after 4 weeks, have a large amount of callus formation, functional rehabilitation.
Case five: cold certain, man, 48 years old, right dislocation of the shonlder joint, swelling pain, after manual reduction, spray the embodiment of the present invention 5
Pharmaceutical composition, 5 hours/time, after 24 hours, swelling pain is completely eliminated, rehabilitation after 7 days, non-functional obstacle.
Case six: Lee, 41 years old, right dislocation of elbow joint, after manual reduction, the spray embodiment of the present invention 6 pharmaceutical composition, 5
Hour/time, after 2 days, swelling pain is completely eliminated, non-functional obstacle.
Case seven: Feng, man, 36 years old, left foot bruise, swelling pain, walking disorder, sprays the embodiment of the present invention 7 medicine
Compositions, 5 hours/time, pain relief after 24 hours, swelling pain substantially eliminates, and after 3 days, swelling pain is completely eliminated, walking
Freely fully recover.
Case eight: Wu, man, 45 years old, right hand middle finger swelled and ache, heating, congestion and swelling pain, swelling such as tumor, and spray is the present invention implement
Example 8 pharmaceutical composition, 5 hours/time, pain relief after 24 hours, medication 2 days, elimination recovery from illness of swelling and ache.
Case nine: Korea Spro, man, 28 years old, left hand fracture of radius, after hospitalize, leave sequela, fracture site is micro-swollen
Pain, sprays the embodiment of the present invention 9 pharmaceutical composition, 5 hours/time, pain relief after 26 hours, i.e. fully recovers after one week.
Although, used general explanation, detailed description of the invention and test, the present invention made detailed retouching
Stating, but on the basis of the present invention, it can be made some amendments or improve, this is aobvious and easy to those skilled in the art
See.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to claimed
Scope.
Claims (10)
1. the pharmaceutical composition of a set a broken bone, it is characterised in that this pharmaceutical composition is made up of the medicine of following weight portion:
Flos Buddlejae 5-15 part, Semen Coicis 15-45 part, Herba Dianthi 10-30 part, Corallium Japonicum Kishinouye 10-35 part, Fructus Ligustri Lucidi 20-40 part, Radix Cynanchi Atrati 10-30 part,
Radix Polygalae 10-30 part, Herba Schizonepetae 15-35 part, Fructus Gardeniae 15-35 part, Tufa 10-30 part, Flos Carthami 10-30 part, Radix Glycyrrhizae 15-30 part.
Pharmaceutical composition the most according to claim 1, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Flos Buddlejae 7-13 part, Semen Coicis 18-42 part, Herba Dianthi 12-28 part, Corallium Japonicum Kishinouye 12-32 part, Fructus Ligustri Lucidi 22-38 part, Radix Cynanchi Atrati 12-
28 parts, Radix Polygalae 12-28 part, Herba Schizonepetae 18-32 part, Fructus Gardeniae 18-32 part, Tufa 12-28 part, Flos Carthami 12-28 part, Radix Glycyrrhizae 18-
28 parts.
Pharmaceutical composition the most according to claim 2, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Flos Buddlejae 8-12 part, Semen Coicis 22-38 part, Herba Dianthi 15-25 part, Corallium Japonicum Kishinouye 15-28 part, Fructus Ligustri Lucidi 25-35 part, Radix Cynanchi Atrati 15-
25 parts, Radix Polygalae 15-25 part, Herba Schizonepetae 20-30 part, Fructus Gardeniae 20-30 part, Tufa 15-25 part, Flos Carthami 15-25 part, Radix Glycyrrhizae 20-
26 parts.
Pharmaceutical composition the most according to claim 3, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Flos Buddlejae 9-11 part, Semen Coicis 25-35 part, Herba Dianthi 18-22 part, Corallium Japonicum Kishinouye 18-25 part, Fructus Ligustri Lucidi 28-32 part, Radix Cynanchi Atrati 18-
23 parts, Radix Polygalae 18-23 part, Herba Schizonepetae 22-28 part, Fructus Gardeniae 22-28 part, Tufa 17-23 part, Flos Carthami 17-23 part, Radix Glycyrrhizae 22-
24 parts.
Pharmaceutical composition the most according to claim 3, it is characterised in that this pharmaceutical composition is by the medicine of following weight portion
Make: Flos Buddlejae 10 parts, Semen Coicis 30 parts, Herba Dianthi 20 parts, 22 parts of Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi 30 parts, Radix Cynanchi Atrati 20 parts, Radix Polygalae 20 parts, chaste tree
Mustard fringe 25 parts, Fructus Gardeniae 25 parts, Tufa 20 parts, 20 parts of Flos Carthami, 23 parts of Radix Glycyrrhizae.
6. according to the pharmaceutical composition described in any one of claim 1-5, it is characterised in that this pharmaceutical composition is possibly together with pharmacy
Upper acceptable carrier or diluent.
Pharmaceutical composition the most according to claim 6, it is characterised in that described pharmaceutical composition is liquid preparation；Described
Liquid preparation spray.
8. the method for the pharmaceutical composition prepared described in any one of claim 1-5, it is characterised in that the method include with
Lower step: by Flos Buddlejae, Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa, Flos Carthami, sweet
Grass pulverizes and sieves, and mixs homogeneously with pharmaceutically acceptable carrier or diluent, is prepared as preparation.
9. prepare the method for pharmaceutical composition described in any one of claim 1-5 for one kind, it is characterised in that the method includes following
Step:
1) Flos Buddlejae adds 2-4 times amount vinegar soak 2-5 hour, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 2-5 times amount soak by water
1-3 hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；Filtering residue adds the ethanol leaching of 2-5 times amount 75%
Steep 2-5 hour, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merge and impregnate
Liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
The preparation method of pharmaceutical composition the most according to claim 9, it is characterised in that the method comprises the following steps:
1) Flos Buddlejae adds 3 times amount vinegar soak 3 hours, filter, filtrate concentrate drying, be ground into fine powder, standby；
2) Flos Carthami powder is broken into fine powder standby；
3) Semen Coicis, Herba Dianthi, Corallium Japonicum Kishinouye, Fructus Ligustri Lucidi, Radix Cynanchi Atrati, Radix Polygalae, Herba Schizonepetae, Fructus Gardeniae, Tufa are added 3 times amount soak by water 2
Hour, filter, merging filtrate, filtrate concentrate drying, be ground into fine powder standby；The soak with ethanol 3 that filtering residue adds 3 times amount 75% is little
Time, filter, filtrate concentrate drying, be ground into fine powder, standby；
4) by above-mentioned standby fine powder mix homogeneously, add by 3 times amount 75% alcohol dipping 2 times, each 1 hour, merge and impregnate
Liquid, filters, stirs, airtight, stands 7 hours, in filling device spray bottle, obtains spray.
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| CN1522717A (en) * | 2003-02-18 | 2004-08-25 | 吴依明 | Trauma treating medicament and method for making same |
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Effective date of registration: 20190103 Address after: 277000 Central Hospital of Jujube Mining Group, 2666 Qilian Mountain Road, New City, Zaozhuang City, Shandong Province Applicant after: Wang Jian Applicant after: Zhang Na Address before: 264504 14, Lou Shan, Silver Beach, Rushan, Shandong. Applicant before: Lin Haiyan |
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